JPS56152478A - Optically active cephalosporin analog - Google Patents

Optically active cephalosporin analog

Info

Publication number
JPS56152478A
JPS56152478A JP5561880A JP5561880A JPS56152478A JP S56152478 A JPS56152478 A JP S56152478A JP 5561880 A JP5561880 A JP 5561880A JP 5561880 A JP5561880 A JP 5561880A JP S56152478 A JPS56152478 A JP S56152478A
Authority
JP
Japan
Prior art keywords
optically active
microorganism
cis
atoms
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5561880A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Yukio Hashimoto
Takehiro Ogasa
Shigeru Kobayashi
Akira Sato
Kiyoshi Sato
Seigo Takazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP5561880A priority Critical patent/JPS56152478A/en
Priority to ES495036A priority patent/ES8200142A1/en
Priority to DK389180A priority patent/DK389180A/en
Priority to AU62355/80A priority patent/AU6235580A/en
Priority to DE8080105493T priority patent/DE3069901D1/en
Priority to EP80105493A priority patent/EP0027882B1/en
Priority to NO802714A priority patent/NO802714L/en
Priority to CA000360254A priority patent/CA1160584A/en
Priority to US06/200,551 priority patent/US4302540A/en
Publication of JPS56152478A publication Critical patent/JPS56152478A/en
Pending legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl, lower acyl; R2 is H, ester residue; H atoms on the 6 and 7 positions are in cis) and their salts.
EXAMPLE: (4S,6R,7S)-7-amino-4-hydroxy-1-azabicyclo[4,2,0]-oct-2-ene-8-one-2-carboxylic acid.
USE: Antibiotic.
PREPARATION: A compound of formula II (R is unsubstituted or substituted unsaturated 6-membered carbon ring, 5-membered heterocyclic ring; X is H, amino, hydroxyl, lower alkyl; the H atoms on the 6 and 7 positions are in cis) is deacylated with optical selectivity in the presence of a microorganism such as Kluyvera citrophila ATCC 21285 strain, its culture mixture, and/or the enzymes produced by the microorganism, e.g., at 15W35°C and 5W10pH.
COPYRIGHT: (C)1981,JPO&Japio
JP5561880A 1979-10-25 1980-04-26 Optically active cephalosporin analog Pending JPS56152478A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP5561880A JPS56152478A (en) 1980-04-26 1980-04-26 Optically active cephalosporin analog
ES495036A ES8200142A1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use.
DK389180A DK389180A (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS AND SALTS THEREOF, AND METHOD OF PRODUCING THEREOF
AU62355/80A AU6235580A (en) 1979-10-25 1980-09-12 Cephalosporin analogs
DE8080105493T DE3069901D1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
EP80105493A EP0027882B1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
NO802714A NO802714L (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS AND SALTS THEREOF, AND PROCEDURES FOR PREPARING THEREOF
CA000360254A CA1160584A (en) 1979-10-25 1980-09-15 Cephalosporin analogs
US06/200,551 US4302540A (en) 1979-10-25 1980-10-24 Process of producing optically active cephalosporin analogs by enzyme selective deacylation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5561880A JPS56152478A (en) 1980-04-26 1980-04-26 Optically active cephalosporin analog

Publications (1)

Publication Number Publication Date
JPS56152478A true JPS56152478A (en) 1981-11-26

Family

ID=13003757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5561880A Pending JPS56152478A (en) 1979-10-25 1980-04-26 Optically active cephalosporin analog

Country Status (1)

Country Link
JP (1) JPS56152478A (en)

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