JPS57200380A - Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations - Google Patents

Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations

Info

Publication number
JPS57200380A
JPS57200380A JP8555781A JP8555781A JPS57200380A JP S57200380 A JPS57200380 A JP S57200380A JP 8555781 A JP8555781 A JP 8555781A JP 8555781 A JP8555781 A JP 8555781A JP S57200380 A JPS57200380 A JP S57200380A
Authority
JP
Japan
Prior art keywords
substance
water
formula
enzyme inhibitor
decomposition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8555781A
Other languages
Japanese (ja)
Inventor
Hamao Umezawa
Tomio Takeuchi
Masa Hamada
Shinichi Kondo
Tsutomu Sawa
Yoko Ikeda
Shozo Tsuchiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP8555781A priority Critical patent/JPS57200380A/en
Publication of JPS57200380A publication Critical patent/JPS57200380A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Antibiotic MG 299 substance shown by the formula (X is -CH=CH-group or -CH2-CH2) or its alkali addition salt. MG 299-A substance. Appearance: white hygroscopic powder. Melting point: 118°C (decomposition). Specific rotatory powder:[α]D22=+10(C=1, water). Molecular formula: C40 H72O18S4 Na4.H2O. MG 299-B substance. Appearance: white hygroscopic powder. Melting point: 122°C (decomposition). Specific rotatory power:[α]D22=+12 (C=1, water). Molecular formula: C40H74O18S4Na4.2H2O.
USE: An enzyme inhibitor. Having strong beta-lactamase inhibiting action.
PROCESS: A spore of hypha of strain MG 299-fF (FERM-P 5872) belonging to the genus Micromonospora is inoculated into a medium containing nutritive sources, cultivates by liquid culture under aerobic conditions at 25W35°C for 3W7 days, and the culture is adsorbed on active carbon, etc. and eluted with water, methanol, propanol, etc., to give MG 299 substance shown by the formula.
COPYRIGHT: (C)1982,JPO&Japio
JP8555781A 1981-06-05 1981-06-05 Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations Pending JPS57200380A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8555781A JPS57200380A (en) 1981-06-05 1981-06-05 Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8555781A JPS57200380A (en) 1981-06-05 1981-06-05 Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations

Publications (1)

Publication Number Publication Date
JPS57200380A true JPS57200380A (en) 1982-12-08

Family

ID=13862113

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8555781A Pending JPS57200380A (en) 1981-06-05 1981-06-05 Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations

Country Status (1)

Country Link
JP (1) JPS57200380A (en)

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