JPS57200380A - Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations - Google Patents
Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparationsInfo
- Publication number
- JPS57200380A JPS57200380A JP8555781A JP8555781A JPS57200380A JP S57200380 A JPS57200380 A JP S57200380A JP 8555781 A JP8555781 A JP 8555781A JP 8555781 A JP8555781 A JP 8555781A JP S57200380 A JPS57200380 A JP S57200380A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- water
- formula
- enzyme inhibitor
- decomposition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Antibiotic MG 299 substance shown by the formula (X is -CH=CH-group or -CH2-CH2) or its alkali addition salt. MG 299-A substance. Appearance: white hygroscopic powder. Melting point: 118°C (decomposition). Specific rotatory powder:[α]D22=+10(C=1, water). Molecular formula: C40 H72O18S4 Na4.H2O. MG 299-B substance. Appearance: white hygroscopic powder. Melting point: 122°C (decomposition). Specific rotatory power:[α]D22=+12 (C=1, water). Molecular formula: C40H74O18S4Na4.2H2O.
USE: An enzyme inhibitor. Having strong beta-lactamase inhibiting action.
PROCESS: A spore of hypha of strain MG 299-fF (FERM-P 5872) belonging to the genus Micromonospora is inoculated into a medium containing nutritive sources, cultivates by liquid culture under aerobic conditions at 25W35°C for 3W7 days, and the culture is adsorbed on active carbon, etc. and eluted with water, methanol, propanol, etc., to give MG 299 substance shown by the formula.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8555781A JPS57200380A (en) | 1981-06-05 | 1981-06-05 | Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8555781A JPS57200380A (en) | 1981-06-05 | 1981-06-05 | Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57200380A true JPS57200380A (en) | 1982-12-08 |
Family
ID=13862113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8555781A Pending JPS57200380A (en) | 1981-06-05 | 1981-06-05 | Novel enzyme inhibitor mg 299-a substance and/or mg 299-b substance and their preparations |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57200380A (en) |
-
1981
- 1981-06-05 JP JP8555781A patent/JPS57200380A/en active Pending
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