JPS5661377A - Optically active cephaloasporin analog - Google Patents

Optically active cephaloasporin analog

Info

Publication number
JPS5661377A
JPS5661377A JP13698679A JP13698679A JPS5661377A JP S5661377 A JPS5661377 A JP S5661377A JP 13698679 A JP13698679 A JP 13698679A JP 13698679 A JP13698679 A JP 13698679A JP S5661377 A JPS5661377 A JP S5661377A
Authority
JP
Japan
Prior art keywords
formula
microorganism
compound
amino
cephaloasporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13698679A
Other languages
Japanese (ja)
Other versions
JPS6354715B2 (en
Inventor
Tadashi Hirata
Yukio Hashimoto
Takehiro Ogasa
Shigeru Kobayashi
Akira Sato
Kiyoshi Sato
Seigo Takazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP13698679A priority Critical patent/JPS5661377A/en
Priority to EP80105493A priority patent/EP0027882B1/en
Priority to AU62355/80A priority patent/AU6235580A/en
Priority to DE8080105493T priority patent/DE3069901D1/en
Priority to ES495036A priority patent/ES8200142A1/en
Priority to NO802714A priority patent/NO802714L/en
Priority to DK389180A priority patent/DK389180A/en
Priority to CA000360254A priority patent/CA1160584A/en
Priority to US06/200,551 priority patent/US4302540A/en
Publication of JPS5661377A publication Critical patent/JPS5661377A/en
Publication of JPS6354715B2 publication Critical patent/JPS6354715B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I (R is H, lower alkyl, etc.; R2 is H or ester residue; Hs at the 6- and 7-positions are in the cis-relation) and a salt thereof.
EXAMPLE: ( 4S,6R,7S )-7-Amino-4-hydroxy-1-azabicyclo[ 4,2,0 ]-oct-2-en-8-one-2- carboxylic acid.
USE: An anti microbial agent having a stronger antimicrobial activity than the optically inactive isomer (dl-form)coirresponding to the acyl derivative.
PROCESS: A compound of formula II (R is substituted or unsubstituted unsaturated 6-membered carbon ring, etc.; X is H, amino, etc.) is deacylated optically and selectively to give the compound of formula I. A mnicroorganism, a cultivated substance thereof and/or an enzyme produced by said microorganism may be used for the deacylation. A microorganism belonging to the genuses Aeromonas, Achromobacter, etc. may be cited as the microorganism.
COPYRIGHT: (C)1981,JPO&Japio
JP13698679A 1979-10-25 1979-10-25 Optically active cephaloasporin analog Granted JPS5661377A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP13698679A JPS5661377A (en) 1979-10-25 1979-10-25 Optically active cephaloasporin analog
EP80105493A EP0027882B1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
AU62355/80A AU6235580A (en) 1979-10-25 1980-09-12 Cephalosporin analogs
DE8080105493T DE3069901D1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
ES495036A ES8200142A1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use.
NO802714A NO802714L (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS AND SALTS THEREOF, AND PROCEDURES FOR PREPARING THEREOF
DK389180A DK389180A (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS AND SALTS THEREOF, AND METHOD OF PRODUCING THEREOF
CA000360254A CA1160584A (en) 1979-10-25 1980-09-15 Cephalosporin analogs
US06/200,551 US4302540A (en) 1979-10-25 1980-10-24 Process of producing optically active cephalosporin analogs by enzyme selective deacylation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13698679A JPS5661377A (en) 1979-10-25 1979-10-25 Optically active cephaloasporin analog

Publications (2)

Publication Number Publication Date
JPS5661377A true JPS5661377A (en) 1981-05-26
JPS6354715B2 JPS6354715B2 (en) 1988-10-28

Family

ID=15188097

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13698679A Granted JPS5661377A (en) 1979-10-25 1979-10-25 Optically active cephaloasporin analog

Country Status (1)

Country Link
JP (1) JPS5661377A (en)

Also Published As

Publication number Publication date
JPS6354715B2 (en) 1988-10-28

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