JPS5661377A - Optically active cephaloasporin analog - Google Patents
Optically active cephaloasporin analogInfo
- Publication number
- JPS5661377A JPS5661377A JP13698679A JP13698679A JPS5661377A JP S5661377 A JPS5661377 A JP S5661377A JP 13698679 A JP13698679 A JP 13698679A JP 13698679 A JP13698679 A JP 13698679A JP S5661377 A JPS5661377 A JP S5661377A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- microorganism
- compound
- amino
- cephaloasporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound of formula I (R is H, lower alkyl, etc.; R2 is H or ester residue; Hs at the 6- and 7-positions are in the cis-relation) and a salt thereof.
EXAMPLE: ( 4S,6R,7S )-7-Amino-4-hydroxy-1-azabicyclo[ 4,2,0 ]-oct-2-en-8-one-2- carboxylic acid.
USE: An anti microbial agent having a stronger antimicrobial activity than the optically inactive isomer (dl-form)coirresponding to the acyl derivative.
PROCESS: A compound of formula II (R is substituted or unsubstituted unsaturated 6-membered carbon ring, etc.; X is H, amino, etc.) is deacylated optically and selectively to give the compound of formula I. A mnicroorganism, a cultivated substance thereof and/or an enzyme produced by said microorganism may be used for the deacylation. A microorganism belonging to the genuses Aeromonas, Achromobacter, etc. may be cited as the microorganism.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13698679A JPS5661377A (en) | 1979-10-25 | 1979-10-25 | Optically active cephaloasporin analog |
EP80105493A EP0027882B1 (en) | 1979-10-25 | 1980-09-12 | Optically active cephalosporin analogs, process for their preparation and their use |
AU62355/80A AU6235580A (en) | 1979-10-25 | 1980-09-12 | Cephalosporin analogs |
DE8080105493T DE3069901D1 (en) | 1979-10-25 | 1980-09-12 | Optically active cephalosporin analogs, process for their preparation and their use |
ES495036A ES8200142A1 (en) | 1979-10-25 | 1980-09-12 | Optically active cephalosporin analogs, process for their preparation and their use. |
NO802714A NO802714L (en) | 1979-10-25 | 1980-09-12 | OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS AND SALTS THEREOF, AND PROCEDURES FOR PREPARING THEREOF |
DK389180A DK389180A (en) | 1979-10-25 | 1980-09-12 | OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS AND SALTS THEREOF, AND METHOD OF PRODUCING THEREOF |
CA000360254A CA1160584A (en) | 1979-10-25 | 1980-09-15 | Cephalosporin analogs |
US06/200,551 US4302540A (en) | 1979-10-25 | 1980-10-24 | Process of producing optically active cephalosporin analogs by enzyme selective deacylation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13698679A JPS5661377A (en) | 1979-10-25 | 1979-10-25 | Optically active cephaloasporin analog |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5661377A true JPS5661377A (en) | 1981-05-26 |
JPS6354715B2 JPS6354715B2 (en) | 1988-10-28 |
Family
ID=15188097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13698679A Granted JPS5661377A (en) | 1979-10-25 | 1979-10-25 | Optically active cephaloasporin analog |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5661377A (en) |
-
1979
- 1979-10-25 JP JP13698679A patent/JPS5661377A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6354715B2 (en) | 1988-10-28 |
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