JPS5630976A - Optically active cephalosporin analog - Google Patents

Optically active cephalosporin analog

Info

Publication number
JPS5630976A
JPS5630976A JP10707079A JP10707079A JPS5630976A JP S5630976 A JPS5630976 A JP S5630976A JP 10707079 A JP10707079 A JP 10707079A JP 10707079 A JP10707079 A JP 10707079A JP S5630976 A JPS5630976 A JP S5630976A
Authority
JP
Japan
Prior art keywords
optically active
formula
active cephalosporin
cis
optically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10707079A
Other languages
Japanese (ja)
Other versions
JPS6350356B2 (en
Inventor
Tadashi Hirata
Yukio Hashimoto
Takehiro Ogasa
Shigeru Kobayashi
Masao Matsukuma
Kazuo Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP10707079A priority Critical patent/JPS5630976A/en
Priority to NO800314A priority patent/NO155547C/en
Priority to US06/119,451 priority patent/US4316958A/en
Priority to CA000345347A priority patent/CA1146886A/en
Priority to AR279911A priority patent/AR226552A1/en
Priority to DE8080100663T priority patent/DE3066533D1/en
Priority to EP80100663A priority patent/EP0014475B1/en
Priority to ES488427A priority patent/ES8101646A1/en
Priority to DK054980A priority patent/DK170072B1/en
Priority to AU55381/80A priority patent/AU5538180A/en
Publication of JPS5630976A publication Critical patent/JPS5630976A/en
Publication of JPS6350356B2 publication Critical patent/JPS6350356B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl; R2 is H, ester residue; hydrogen atoms on the 6 and 7 positions are in the relation of cis) or their salts.
EXAMPLE: (+)-7β-Amino-1-azabicyclo[4,2,0]oct-2-en-8-one-2-carboxylic acid.
USE: Intermediate of antibacterial. The acyl derivative has very strong antibactieral activity in comparison with that of the acyl derivative of the optically inactive derivative. The compounds, themselves, can be expected to have antibacterial activity, too.
PREPARATION: The optically selective deacylation of a compound of formula III (R is substituted or unsubstituted unsaturated six-membered carbon ring or five- membered heterocyclic ring; X is H, amino, hydroxyl, lower alkyl; hydrogen atoms on the 6 and 7 positions are in the relation of cis) is effected by using a microorganism capable of producing optically active cephalosporin analogs to form the compound of formula I in high yield.
COPYRIGHT: (C)1981,JPO&Japio
JP10707079A 1979-02-10 1979-08-24 Optically active cephalosporin analog Granted JPS5630976A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP10707079A JPS5630976A (en) 1979-08-24 1979-08-24 Optically active cephalosporin analog
NO800314A NO155547C (en) 1979-02-10 1980-02-06 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGS AND SALTS THEREOF AND THE PROCEDURE FOR THEIR PREPARATION.
US06/119,451 US4316958A (en) 1979-02-10 1980-02-07 Process for producing optically active cephalosporin analogs
CA000345347A CA1146886A (en) 1979-02-10 1980-02-07 Optically active cephalosporin analogs
AR279911A AR226552A1 (en) 1979-02-10 1980-02-08 PROCEDURE FOR PRODUCING A 7-AMINO-1-AZABICICLO ACID (4.2.0.) OCT-2-2-EN 8-ON-CARBOXILICO OPTICALLY ACTIVE
DE8080100663T DE3066533D1 (en) 1979-02-10 1980-02-08 Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions
EP80100663A EP0014475B1 (en) 1979-02-10 1980-02-08 Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions
ES488427A ES8101646A1 (en) 1979-02-10 1980-02-08 Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions.
DK054980A DK170072B1 (en) 1979-02-10 1980-02-08 Optically active cephalosporin analogs and salts thereof, and process for their preparation
AU55381/80A AU5538180A (en) 1979-02-10 1980-02-08 1-azabicyclo (4,2,0) oct-2-en derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10707079A JPS5630976A (en) 1979-08-24 1979-08-24 Optically active cephalosporin analog

Publications (2)

Publication Number Publication Date
JPS5630976A true JPS5630976A (en) 1981-03-28
JPS6350356B2 JPS6350356B2 (en) 1988-10-07

Family

ID=14449717

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10707079A Granted JPS5630976A (en) 1979-02-10 1979-08-24 Optically active cephalosporin analog

Country Status (1)

Country Link
JP (1) JPS5630976A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128591A (en) * 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5549376A (en) * 1978-10-04 1980-04-09 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5559186A (en) * 1978-10-28 1980-05-02 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5587788A (en) * 1978-12-26 1980-07-02 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128591A (en) * 1978-03-25 1979-10-05 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5549376A (en) * 1978-10-04 1980-04-09 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5559186A (en) * 1978-10-28 1980-05-02 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
JPS5587788A (en) * 1978-12-26 1980-07-02 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog

Also Published As

Publication number Publication date
JPS6350356B2 (en) 1988-10-07

Similar Documents

Publication Publication Date Title
ES8202546A1 (en) Thiazolidine derivatives and their production and use.
ES468267A1 (en) 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo{8 1,2-a{9 pyrrole-1-carboxylic acid derivatives and process for the production thereof
IE41528L (en) Furfuryl-benzomorphane derivatives.
WO1999020639A3 (en) NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
IE36084B1 (en) 3-methylene cephalosporins
IE800688L (en) Xanthine derivatives
IE780119L (en) IMIDAZO(1,2-a) QUINOLINE-2-CARBOXYLIC ACIDS
ES8609195A1 (en) Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives.
ES8304142A1 (en) 2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxylic acids
JPS5630976A (en) Optically active cephalosporin analog
ES536649A0 (en) PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF ESTRANO AND ANDROSTANO
MY101993A (en) Cephalosporin ester derivatives their production and use.
IE791578L (en) Acetylene derivatives of androstenes
IE45110L (en) Phenethylamine derivatives
GB1448758A (en) Thiazole derivatives
JPS55108872A (en) Optically active cephalosporin analog
IE39543L (en) Cephalosporins
JPS5272886A (en) Preparation of cephalosporin compound
JPS55145669A (en) 8,10-diazaprostanoic acid derivative and its preparation
ES449446A1 (en) 1-Oxo-1H-6-piperidinopyrimido{8 1,2-a{9 quinoline-2-carboxylic acids and esters
IE790924L (en) 1,3-benzodioxin derivatives
IE42960L (en) Thiazolecarboxamides
GB2001974A (en) Vincinic acid derivatives and process for the preparation thereof
JPS55138396A (en) Production of cephalosporin analogs
JPS56152479A (en) Optically active cephalosporin analog