JPS5630976A - Optically active cephalosporin analog - Google Patents
Optically active cephalosporin analogInfo
- Publication number
- JPS5630976A JPS5630976A JP10707079A JP10707079A JPS5630976A JP S5630976 A JPS5630976 A JP S5630976A JP 10707079 A JP10707079 A JP 10707079A JP 10707079 A JP10707079 A JP 10707079A JP S5630976 A JPS5630976 A JP S5630976A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- formula
- active cephalosporin
- cis
- optically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl; R2 is H, ester residue; hydrogen atoms on the 6 and 7 positions are in the relation of cis) or their salts.
EXAMPLE: (+)-7β-Amino-1-azabicyclo[4,2,0]oct-2-en-8-one-2-carboxylic acid.
USE: Intermediate of antibacterial. The acyl derivative has very strong antibactieral activity in comparison with that of the acyl derivative of the optically inactive derivative. The compounds, themselves, can be expected to have antibacterial activity, too.
PREPARATION: The optically selective deacylation of a compound of formula III (R is substituted or unsubstituted unsaturated six-membered carbon ring or five- membered heterocyclic ring; X is H, amino, hydroxyl, lower alkyl; hydrogen atoms on the 6 and 7 positions are in the relation of cis) is effected by using a microorganism capable of producing optically active cephalosporin analogs to form the compound of formula I in high yield.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10707079A JPS5630976A (en) | 1979-08-24 | 1979-08-24 | Optically active cephalosporin analog |
NO800314A NO155547C (en) | 1979-02-10 | 1980-02-06 | OPTICALLY ACTIVE CEPHALOSPORIN ANALOGS AND SALTS THEREOF AND THE PROCEDURE FOR THEIR PREPARATION. |
US06/119,451 US4316958A (en) | 1979-02-10 | 1980-02-07 | Process for producing optically active cephalosporin analogs |
CA000345347A CA1146886A (en) | 1979-02-10 | 1980-02-07 | Optically active cephalosporin analogs |
AR279911A AR226552A1 (en) | 1979-02-10 | 1980-02-08 | PROCEDURE FOR PRODUCING A 7-AMINO-1-AZABICICLO ACID (4.2.0.) OCT-2-2-EN 8-ON-CARBOXILICO OPTICALLY ACTIVE |
DE8080100663T DE3066533D1 (en) | 1979-02-10 | 1980-02-08 | Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions |
EP80100663A EP0014475B1 (en) | 1979-02-10 | 1980-02-08 | Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions |
ES488427A ES8101646A1 (en) | 1979-02-10 | 1980-02-08 | Optically active cephalosporin analogs, process for their preparation and their use in the preparation of pharmaceutical compositions. |
DK054980A DK170072B1 (en) | 1979-02-10 | 1980-02-08 | Optically active cephalosporin analogs and salts thereof, and process for their preparation |
AU55381/80A AU5538180A (en) | 1979-02-10 | 1980-02-08 | 1-azabicyclo (4,2,0) oct-2-en derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10707079A JPS5630976A (en) | 1979-08-24 | 1979-08-24 | Optically active cephalosporin analog |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5630976A true JPS5630976A (en) | 1981-03-28 |
JPS6350356B2 JPS6350356B2 (en) | 1988-10-07 |
Family
ID=14449717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10707079A Granted JPS5630976A (en) | 1979-02-10 | 1979-08-24 | Optically active cephalosporin analog |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5630976A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54128591A (en) * | 1978-03-25 | 1979-10-05 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5549376A (en) * | 1978-10-04 | 1980-04-09 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5559186A (en) * | 1978-10-28 | 1980-05-02 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5587788A (en) * | 1978-12-26 | 1980-07-02 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
-
1979
- 1979-08-24 JP JP10707079A patent/JPS5630976A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54128591A (en) * | 1978-03-25 | 1979-10-05 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5549376A (en) * | 1978-10-04 | 1980-04-09 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5559186A (en) * | 1978-10-28 | 1980-05-02 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
JPS5587788A (en) * | 1978-12-26 | 1980-07-02 | Kyowa Hakko Kogyo Co Ltd | Cephalosporin analog |
Also Published As
Publication number | Publication date |
---|---|
JPS6350356B2 (en) | 1988-10-07 |
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