JPS5729291A - Preparation of optically active cephalosporin analoge - Google Patents
Preparation of optically active cephalosporin analogeInfo
- Publication number
- JPS5729291A JPS5729291A JP10242280A JP10242280A JPS5729291A JP S5729291 A JPS5729291 A JP S5729291A JP 10242280 A JP10242280 A JP 10242280A JP 10242280 A JP10242280 A JP 10242280A JP S5729291 A JPS5729291 A JP S5729291A
- Authority
- JP
- Japan
- Prior art keywords
- microorganism
- substance
- enzyme produced
- optically active
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare the titled substance, by subjecting a specific compound to the action of a microorganism having the ability to produce the titled substance, a cultivated substance thereof or an enzyme produced by the microorganism.
CONSTITUTION: An enzyme produced by a microorganism capable of carrying out the optically selective deacylating reaction, e.g. Nocardia globerula ATCC 21022, Neurospora sitophila IFO 4596 or Acinetobacter calcoaceticus ATCC 21288, a cultivated substance or a treated culture of the microorganism, separated microbial cell, crushed microbial cell or purified enzymic solution, is prepared. A compound of formula I (R1 is hydrogen, lower alkyl, hydroxyl group, etc.; R2 is hydrogen, protecting group of the carboxylic acid; the hydrogens at the 6- and 7- positions are in the cis relation) is dissolved in water, an organic solvent, etc., and subjected to the action of the enzyme produced by the microorganism, etc. to produce the aimed optically active cephalosporin analog of formula II which is then isolated by the adsorption, chromatography, gel filtration, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10242280A JPS5729291A (en) | 1980-07-28 | 1980-07-28 | Preparation of optically active cephalosporin analoge |
EP80105493A EP0027882B1 (en) | 1979-10-25 | 1980-09-12 | Optically active cephalosporin analogs, process for their preparation and their use |
DK389180A DK389180A (en) | 1979-10-25 | 1980-09-12 | OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS AND SALTS THEREOF, AND METHOD OF PRODUCING THEREOF |
ES495036A ES495036A0 (en) | 1979-10-25 | 1980-09-12 | A PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORIN ANALOGS. |
AU62355/80A AU6235580A (en) | 1979-10-25 | 1980-09-12 | Cephalosporin analogs |
DE8080105493T DE3069901D1 (en) | 1979-10-25 | 1980-09-12 | Optically active cephalosporin analogs, process for their preparation and their use |
NO802714A NO802714L (en) | 1979-10-25 | 1980-09-12 | OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS AND SALTS THEREOF, AND PROCEDURES FOR PREPARING THEREOF |
CA000360254A CA1160584A (en) | 1979-10-25 | 1980-09-15 | Cephalosporin analogs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10242280A JPS5729291A (en) | 1980-07-28 | 1980-07-28 | Preparation of optically active cephalosporin analoge |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5729291A true JPS5729291A (en) | 1982-02-17 |
JPS6338195B2 JPS6338195B2 (en) | 1988-07-28 |
Family
ID=14327007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10242280A Granted JPS5729291A (en) | 1979-10-25 | 1980-07-28 | Preparation of optically active cephalosporin analoge |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5729291A (en) |
-
1980
- 1980-07-28 JP JP10242280A patent/JPS5729291A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6338195B2 (en) | 1988-07-28 |
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