JPS5729291A - Preparation of optically active cephalosporin analoge - Google Patents

Preparation of optically active cephalosporin analoge

Info

Publication number
JPS5729291A
JPS5729291A JP10242280A JP10242280A JPS5729291A JP S5729291 A JPS5729291 A JP S5729291A JP 10242280 A JP10242280 A JP 10242280A JP 10242280 A JP10242280 A JP 10242280A JP S5729291 A JPS5729291 A JP S5729291A
Authority
JP
Japan
Prior art keywords
microorganism
substance
enzyme produced
optically active
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10242280A
Other languages
Japanese (ja)
Other versions
JPS6338195B2 (en
Inventor
Yukio Hashimoto
Seigo Takazawa
Tadashi Hirata
Fumio Suzuki
Shigeru Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP10242280A priority Critical patent/JPS5729291A/en
Priority to EP80105493A priority patent/EP0027882B1/en
Priority to DK389180A priority patent/DK389180A/en
Priority to ES495036A priority patent/ES495036A0/en
Priority to AU62355/80A priority patent/AU6235580A/en
Priority to DE8080105493T priority patent/DE3069901D1/en
Priority to NO802714A priority patent/NO802714L/en
Priority to CA000360254A priority patent/CA1160584A/en
Publication of JPS5729291A publication Critical patent/JPS5729291A/en
Publication of JPS6338195B2 publication Critical patent/JPS6338195B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare the titled substance, by subjecting a specific compound to the action of a microorganism having the ability to produce the titled substance, a cultivated substance thereof or an enzyme produced by the microorganism.
CONSTITUTION: An enzyme produced by a microorganism capable of carrying out the optically selective deacylating reaction, e.g. Nocardia globerula ATCC 21022, Neurospora sitophila IFO 4596 or Acinetobacter calcoaceticus ATCC 21288, a cultivated substance or a treated culture of the microorganism, separated microbial cell, crushed microbial cell or purified enzymic solution, is prepared. A compound of formula I (R1 is hydrogen, lower alkyl, hydroxyl group, etc.; R2 is hydrogen, protecting group of the carboxylic acid; the hydrogens at the 6- and 7- positions are in the cis relation) is dissolved in water, an organic solvent, etc., and subjected to the action of the enzyme produced by the microorganism, etc. to produce the aimed optically active cephalosporin analog of formula II which is then isolated by the adsorption, chromatography, gel filtration, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP10242280A 1979-10-25 1980-07-28 Preparation of optically active cephalosporin analoge Granted JPS5729291A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP10242280A JPS5729291A (en) 1980-07-28 1980-07-28 Preparation of optically active cephalosporin analoge
EP80105493A EP0027882B1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
DK389180A DK389180A (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS AND SALTS THEREOF, AND METHOD OF PRODUCING THEREOF
ES495036A ES495036A0 (en) 1979-10-25 1980-09-12 A PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORIN ANALOGS.
AU62355/80A AU6235580A (en) 1979-10-25 1980-09-12 Cephalosporin analogs
DE8080105493T DE3069901D1 (en) 1979-10-25 1980-09-12 Optically active cephalosporin analogs, process for their preparation and their use
NO802714A NO802714L (en) 1979-10-25 1980-09-12 OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS AND SALTS THEREOF, AND PROCEDURES FOR PREPARING THEREOF
CA000360254A CA1160584A (en) 1979-10-25 1980-09-15 Cephalosporin analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10242280A JPS5729291A (en) 1980-07-28 1980-07-28 Preparation of optically active cephalosporin analoge

Publications (2)

Publication Number Publication Date
JPS5729291A true JPS5729291A (en) 1982-02-17
JPS6338195B2 JPS6338195B2 (en) 1988-07-28

Family

ID=14327007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10242280A Granted JPS5729291A (en) 1979-10-25 1980-07-28 Preparation of optically active cephalosporin analoge

Country Status (1)

Country Link
JP (1) JPS5729291A (en)

Also Published As

Publication number Publication date
JPS6338195B2 (en) 1988-07-28

Similar Documents

Publication Publication Date Title
JPS5729291A (en) Preparation of optically active cephalosporin analoge
JPS5799192A (en) Preparation of peroxidase
JPS5743685A (en) L-glutamic oxidase
EP0477829A3 (en) Microbiological process for the preparation of hydroxylated heterocyclic compounds
JPS5545322A (en) Preparation of mitomycins by fermentation
WO1996016053A1 (en) Phthalide compounds and their production process
WO1999012958A3 (en) Ampullosporin, method for producing same and its use
JPS57141296A (en) Fermentation method
JPS56121495A (en) Preparation of benzodiazepine derivative
ES8609356A1 (en) 1-Hydroxy-cytorhodines, a microbiological method for their preparation and their use as cytostatic agents.
JPS57150390A (en) New antibiotic fa-1180b1 or its salt and its preparation
Horiuchi et al. Transesterification of ethylparaben by free and entrapped cells of Pseudomonas cepacia
JPS56139498A (en) Novel antibiotic substance, anthramycin d, and its preparation
JPS5743697A (en) Improved preparation of antibiotic
JPS557A (en) Production of ceftezole
JPS5692786A (en) Cultivation of microorganism
JPS5743693A (en) Preparation of antibiotic tunicamycin
JPS56148292A (en) Preparation of enzyme q9 by fermentation method
JPS55118490A (en) Demethylmaytansinoid compound and its preparation
JPS5664796A (en) Preparation of 6-aminopenicillanic acid and 6- aminopenicillanic acid s-oxide
JPS5648891A (en) Preparation of polysaccharide
JPS56154998A (en) Production of macrolide antibiotic through microbial conversion process
JPS5682100A (en) Production of beta-lactam antibiotic
JPS5452786A (en) Preparation of microbial cells
JPS57102158A (en) Method for inducing lactic acid fermentation of unrefined soy