JPS57150390A - New antibiotic fa-1180b1 or its salt and its preparation - Google Patents

New antibiotic fa-1180b1 or its salt and its preparation

Info

Publication number
JPS57150390A
JPS57150390A JP56036329A JP3632981A JPS57150390A JP S57150390 A JPS57150390 A JP S57150390A JP 56036329 A JP56036329 A JP 56036329A JP 3632981 A JP3632981 A JP 3632981A JP S57150390 A JPS57150390 A JP S57150390A
Authority
JP
Japan
Prior art keywords
antibiotic
actinomadura
cultured
collected
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56036329A
Other languages
Japanese (ja)
Inventor
Hiroyuki Mori
Yasuo Ogawa
Hideo Sugi
Noboru Fujikawa
Kiyoshi Tamai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Priority to JP56036329A priority Critical patent/JPS57150390A/en
Publication of JPS57150390A publication Critical patent/JPS57150390A/en
Pending legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PURPOSE: A strain producing a novel antibiotic in a actinomadura is cultured and the titled substance used as an active ingredient in medicines, because of its activity of inhibiting the growth of gram-positive bacteria, is collected from the culture mixture.
CONSTITUTION: A strain FA-1180 (FERM-5155) in actinomadura is cultured in a usual medium for actinomycetes containing carbon source, nitrogen source, growth accelerator, inorganic salts and others at about 20W40°C and 4W9pH for 7W20 days. The resultant culture mixture is filtered and the filtrate is extracted. The objective substance is separated, collected and purified by utilizing the difference of the antibiotic in adsorptivity or affinity to adsorbents and in solubility in solvents. The resultant antibiotic substance is amphoteric, dark-red needle, melts at 152W154°C and shows Rf=0.45 in the silica-gel thin-layer chromatography developed with chroloform, toluene and methanol.
COPYRIGHT: (C)1982,JPO&Japio
JP56036329A 1981-03-13 1981-03-13 New antibiotic fa-1180b1 or its salt and its preparation Pending JPS57150390A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56036329A JPS57150390A (en) 1981-03-13 1981-03-13 New antibiotic fa-1180b1 or its salt and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56036329A JPS57150390A (en) 1981-03-13 1981-03-13 New antibiotic fa-1180b1 or its salt and its preparation

Publications (1)

Publication Number Publication Date
JPS57150390A true JPS57150390A (en) 1982-09-17

Family

ID=12466791

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56036329A Pending JPS57150390A (en) 1981-03-13 1981-03-13 New antibiotic fa-1180b1 or its salt and its preparation

Country Status (1)

Country Link
JP (1) JPS57150390A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774184A (en) * 1984-03-26 1988-09-27 American Cyanamid Company Culture and process for producing antibiotic LL-D42067alpha
US5427941A (en) * 1985-08-08 1995-06-27 Schering Corporation Actinomadura brunnea var. antibiotica strains

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774184A (en) * 1984-03-26 1988-09-27 American Cyanamid Company Culture and process for producing antibiotic LL-D42067alpha
US5427941A (en) * 1985-08-08 1995-06-27 Schering Corporation Actinomadura brunnea var. antibiotica strains

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