JPS57150390A - New antibiotic fa-1180b1 or its salt and its preparation - Google Patents
New antibiotic fa-1180b1 or its salt and its preparationInfo
- Publication number
- JPS57150390A JPS57150390A JP56036329A JP3632981A JPS57150390A JP S57150390 A JPS57150390 A JP S57150390A JP 56036329 A JP56036329 A JP 56036329A JP 3632981 A JP3632981 A JP 3632981A JP S57150390 A JPS57150390 A JP S57150390A
- Authority
- JP
- Japan
- Prior art keywords
- antibiotic
- actinomadura
- cultured
- collected
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
PURPOSE: A strain producing a novel antibiotic in a actinomadura is cultured and the titled substance used as an active ingredient in medicines, because of its activity of inhibiting the growth of gram-positive bacteria, is collected from the culture mixture.
CONSTITUTION: A strain FA-1180 (FERM-5155) in actinomadura is cultured in a usual medium for actinomycetes containing carbon source, nitrogen source, growth accelerator, inorganic salts and others at about 20W40°C and 4W9pH for 7W20 days. The resultant culture mixture is filtered and the filtrate is extracted. The objective substance is separated, collected and purified by utilizing the difference of the antibiotic in adsorptivity or affinity to adsorbents and in solubility in solvents. The resultant antibiotic substance is amphoteric, dark-red needle, melts at 152W154°C and shows Rf=0.45 in the silica-gel thin-layer chromatography developed with chroloform, toluene and methanol.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56036329A JPS57150390A (en) | 1981-03-13 | 1981-03-13 | New antibiotic fa-1180b1 or its salt and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56036329A JPS57150390A (en) | 1981-03-13 | 1981-03-13 | New antibiotic fa-1180b1 or its salt and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57150390A true JPS57150390A (en) | 1982-09-17 |
Family
ID=12466791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56036329A Pending JPS57150390A (en) | 1981-03-13 | 1981-03-13 | New antibiotic fa-1180b1 or its salt and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57150390A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4774184A (en) * | 1984-03-26 | 1988-09-27 | American Cyanamid Company | Culture and process for producing antibiotic LL-D42067alpha |
US5427941A (en) * | 1985-08-08 | 1995-06-27 | Schering Corporation | Actinomadura brunnea var. antibiotica strains |
-
1981
- 1981-03-13 JP JP56036329A patent/JPS57150390A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4774184A (en) * | 1984-03-26 | 1988-09-27 | American Cyanamid Company | Culture and process for producing antibiotic LL-D42067alpha |
US5427941A (en) * | 1985-08-08 | 1995-06-27 | Schering Corporation | Actinomadura brunnea var. antibiotica strains |
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