JPS54122797A - Preparation of 7-demethoxy-7-aminomitomycin b derivatives - Google Patents

Preparation of 7-demethoxy-7-aminomitomycin b derivatives

Info

Publication number
JPS54122797A
JPS54122797A JP2923878A JP2923878A JPS54122797A JP S54122797 A JPS54122797 A JP S54122797A JP 2923878 A JP2923878 A JP 2923878A JP 2923878 A JP2923878 A JP 2923878A JP S54122797 A JPS54122797 A JP S54122797A
Authority
JP
Japan
Prior art keywords
aminomitomycin
demethoxy
derivatives
culturing
streptomyces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2923878A
Other languages
Japanese (ja)
Inventor
Kimikatsu Shirahata
Masaji Kasai
Isao Matsubara
Chikahiro Urakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2923878A priority Critical patent/JPS54122797A/en
Publication of JPS54122797A publication Critical patent/JPS54122797A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title antibiotic having anti-ulcer activity, by separating and purifying a cultured product obtained by the culturing of fungi belonging to Streptomyces genus.
CONSTITUTION: Fungi belonging to Streptomyces genus and capable of producing 7-demethoxy-7-aminomitomycin B derivatives, e.g. Streptomyces caespitosus ATCC 27422, are cultured in a nutrient medium pref. at 26W32°C under aerobic conditons. After culturing, the medium is filtered and the filtrate is treated with an adsorbent to adsorb the accumulated antibiotic substance, which is purified by e.g. methanol elution, chloroform extraction, adsorption chromatography, etc., to obtain the title antibiotic substance of the formula (R is H, CH3).
COPYRIGHT: (C)1979,JPO&Japio
JP2923878A 1978-03-16 1978-03-16 Preparation of 7-demethoxy-7-aminomitomycin b derivatives Pending JPS54122797A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2923878A JPS54122797A (en) 1978-03-16 1978-03-16 Preparation of 7-demethoxy-7-aminomitomycin b derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2923878A JPS54122797A (en) 1978-03-16 1978-03-16 Preparation of 7-demethoxy-7-aminomitomycin b derivatives

Publications (1)

Publication Number Publication Date
JPS54122797A true JPS54122797A (en) 1979-09-22

Family

ID=12270650

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2923878A Pending JPS54122797A (en) 1978-03-16 1978-03-16 Preparation of 7-demethoxy-7-aminomitomycin b derivatives

Country Status (1)

Country Link
JP (1) JPS54122797A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4691024A (en) * 1984-06-01 1987-09-01 Kyowa Hakko Kogyo Kabushiki Kaisha New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
US4748251A (en) * 1985-01-31 1988-05-31 Kyowa Hakko Kogyo Co., Ltd. 7-n-aminomethylenemitomycin derivative
US4853385A (en) * 1987-03-31 1989-08-01 Kyowa Hakko Kogyo Co., Ltd. 7-N,8-N-Ethylenemitomycin 8-imines
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US5021423A (en) * 1988-05-30 1991-06-04 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives and intermediates therefor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4691024A (en) * 1984-06-01 1987-09-01 Kyowa Hakko Kogyo Kabushiki Kaisha New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
US4748251A (en) * 1985-01-31 1988-05-31 Kyowa Hakko Kogyo Co., Ltd. 7-n-aminomethylenemitomycin derivative
US4880825A (en) * 1987-03-25 1989-11-14 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
EP0284380B1 (en) * 1987-03-25 1992-06-10 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
US4853385A (en) * 1987-03-31 1989-08-01 Kyowa Hakko Kogyo Co., Ltd. 7-N,8-N-Ethylenemitomycin 8-imines
US5021423A (en) * 1988-05-30 1991-06-04 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives and intermediates therefor

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