JPS54122797A - Preparation of 7-demethoxy-7-aminomitomycin b derivatives - Google Patents
Preparation of 7-demethoxy-7-aminomitomycin b derivativesInfo
- Publication number
- JPS54122797A JPS54122797A JP2923878A JP2923878A JPS54122797A JP S54122797 A JPS54122797 A JP S54122797A JP 2923878 A JP2923878 A JP 2923878A JP 2923878 A JP2923878 A JP 2923878A JP S54122797 A JPS54122797 A JP S54122797A
- Authority
- JP
- Japan
- Prior art keywords
- aminomitomycin
- demethoxy
- derivatives
- culturing
- streptomyces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title antibiotic having anti-ulcer activity, by separating and purifying a cultured product obtained by the culturing of fungi belonging to Streptomyces genus.
CONSTITUTION: Fungi belonging to Streptomyces genus and capable of producing 7-demethoxy-7-aminomitomycin B derivatives, e.g. Streptomyces caespitosus ATCC 27422, are cultured in a nutrient medium pref. at 26W32°C under aerobic conditons. After culturing, the medium is filtered and the filtrate is treated with an adsorbent to adsorb the accumulated antibiotic substance, which is purified by e.g. methanol elution, chloroform extraction, adsorption chromatography, etc., to obtain the title antibiotic substance of the formula (R is H, CH3).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2923878A JPS54122797A (en) | 1978-03-16 | 1978-03-16 | Preparation of 7-demethoxy-7-aminomitomycin b derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2923878A JPS54122797A (en) | 1978-03-16 | 1978-03-16 | Preparation of 7-demethoxy-7-aminomitomycin b derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54122797A true JPS54122797A (en) | 1979-09-22 |
Family
ID=12270650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2923878A Pending JPS54122797A (en) | 1978-03-16 | 1978-03-16 | Preparation of 7-demethoxy-7-aminomitomycin b derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54122797A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4691024A (en) * | 1984-06-01 | 1987-09-01 | Kyowa Hakko Kogyo Kabushiki Kaisha | New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them |
US4748251A (en) * | 1985-01-31 | 1988-05-31 | Kyowa Hakko Kogyo Co., Ltd. | 7-n-aminomethylenemitomycin derivative |
US4853385A (en) * | 1987-03-31 | 1989-08-01 | Kyowa Hakko Kogyo Co., Ltd. | 7-N,8-N-Ethylenemitomycin 8-imines |
US4880825A (en) * | 1987-03-25 | 1989-11-14 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives |
US5021423A (en) * | 1988-05-30 | 1991-06-04 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives and intermediates therefor |
-
1978
- 1978-03-16 JP JP2923878A patent/JPS54122797A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4691024A (en) * | 1984-06-01 | 1987-09-01 | Kyowa Hakko Kogyo Kabushiki Kaisha | New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them |
US4748251A (en) * | 1985-01-31 | 1988-05-31 | Kyowa Hakko Kogyo Co., Ltd. | 7-n-aminomethylenemitomycin derivative |
US4880825A (en) * | 1987-03-25 | 1989-11-14 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives |
EP0284380B1 (en) * | 1987-03-25 | 1992-06-10 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives |
US4853385A (en) * | 1987-03-31 | 1989-08-01 | Kyowa Hakko Kogyo Co., Ltd. | 7-N,8-N-Ethylenemitomycin 8-imines |
US5021423A (en) * | 1988-05-30 | 1991-06-04 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives and intermediates therefor |
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