ES8606269A1 - Procedimiento para preparar un derivado de pirrolidina - Google Patents

Procedimiento para preparar un derivado de pirrolidina

Info

Publication number
ES8606269A1
ES8606269A1 ES548744A ES548744A ES8606269A1 ES 8606269 A1 ES8606269 A1 ES 8606269A1 ES 548744 A ES548744 A ES 548744A ES 548744 A ES548744 A ES 548744A ES 8606269 A1 ES8606269 A1 ES 8606269A1
Authority
ES
Spain
Prior art keywords
formula
compound
butyryl
proline
mercapto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548744A
Other languages
English (en)
Other versions
ES548744A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boryung Pharmaceutical Co Ltd
Original Assignee
Boryung Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boryung Pharmaceutical Co Ltd filed Critical Boryung Pharmaceutical Co Ltd
Publication of ES548744A0 publication Critical patent/ES548744A0/es
Publication of ES8606269A1 publication Critical patent/ES8606269A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE PIRROLIDINA. COMPRENDE: A) TRATAR A UN C.D.F. (III) CON UN C.D.F. (IV), EN PRESENCIA DE UNA BASE COMO BICARBONATO SODICO O HIDROXIDO POTASICO, CON UNAS RELACIONES MOLARES DE (III)/(IV) ENTRE 1:1 O 1:3 Y DE (III)/BASE ENTRE 1:0,5 Y 1:2,5, A UNA TEMPERATURA ENTRE 35 Y 120JC, DURANTE 30 MIN A 20 HORAS, PARA OBTENER UN C.D.F.(II) Y B) HIDROLIZAR A (II) CON UNA BASE INORGANICA COMO CARBONATO POTASICO O AMONIACO LIQUIDO, EN AGUA O ETANOL, ENTRE 40 Y 130JC Y CON UNA RELACION MOLAR II/BASE ENTRE 1:1 Y 1:5, PARA OBTENER UN C.D.F. (I). SIENDO: R ALQUILO INFERIOR DE C 1 A 5; M NA O K; Y O O N; C.D.F. COMPUESTO DE FORMULA Y N 1 O 2. SE UTILIZA PARA DISMINUIR LA PRESION SANGUINEA.
ES548744A 1985-02-11 1985-11-11 Procedimiento para preparar un derivado de pirrolidina Expired ES8606269A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850000850A KR870001569B1 (ko) 1985-02-11 1985-02-11 피롤리딘 유도체의 제조방법

Publications (2)

Publication Number Publication Date
ES548744A0 ES548744A0 (es) 1986-04-01
ES8606269A1 true ES8606269A1 (es) 1986-04-01

Family

ID=19239706

Family Applications (1)

Application Number Title Priority Date Filing Date
ES548744A Expired ES8606269A1 (es) 1985-02-11 1985-11-11 Procedimiento para preparar un derivado de pirrolidina

Country Status (6)

Country Link
JP (1) JPS61183263A (es)
KR (1) KR870001569B1 (es)
DE (1) DE3538747A1 (es)
ES (1) ES8606269A1 (es)
FR (1) FR2577222B1 (es)
GB (1) GB2170806B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208954B (en) * 1990-09-21 1994-02-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1-(3-mercapto-(2s)-methyl-1-oxo-propyl)-l-prolyn
US5237073A (en) * 1988-08-26 1993-08-17 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
EP0432204A4 (en) * 1988-08-26 1992-08-12 Sepracor, Inc. Derivatives and precursors of captopril and its analogues
KR940005014B1 (ko) * 1991-11-07 1994-06-09 보령제약 주식회사 피롤리딘카르복실산 유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4192945A (en) * 1978-12-07 1980-03-11 E. R. Squibb & Sons, Inc. Process for preparing proline and homoproline derivatives
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
JPS58124764A (ja) * 1982-01-20 1983-07-25 Kanegafuchi Chem Ind Co Ltd 光学活性チオ−ル化合物の製造法

Also Published As

Publication number Publication date
KR870001569B1 (ko) 1987-09-04
DE3538747A1 (de) 1986-08-14
ES548744A0 (es) 1986-04-01
DE3538747C2 (es) 1988-08-18
FR2577222B1 (fr) 1987-12-24
GB2170806B (en) 1988-08-03
GB8602782D0 (en) 1986-03-12
JPS61183263A (ja) 1986-08-15
GB2170806A (en) 1986-08-13
KR860006441A (ko) 1986-09-11
FR2577222A1 (fr) 1986-08-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402