ES2044886T3 - Procedimiento para la obtencion de derivados fluorados en el nucleo del acido benzoico. - Google Patents

Procedimiento para la obtencion de derivados fluorados en el nucleo del acido benzoico.

Info

Publication number
ES2044886T3
ES2044886T3 ES87113034T ES87113034T ES2044886T3 ES 2044886 T3 ES2044886 T3 ES 2044886T3 ES 87113034 T ES87113034 T ES 87113034T ES 87113034 T ES87113034 T ES 87113034T ES 2044886 T3 ES2044886 T3 ES 2044886T3
Authority
ES
Spain
Prior art keywords
procedure
fluorated
nucleus
derivatives
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87113034T
Other languages
English (en)
Inventor
Uwe Dr Petersen
Michael Dr Schriewer
Ernst Dr Kysela
Klaus Dr Grohe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2044886T3 publication Critical patent/ES2044886T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/38—Acyl halides
    • C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

EL INVENTO CONSISTE EN UN PROCEDIMIENTO PARA LA FABRICACION DE LA COMBINACION DE LA FORMULA (I), DONDE X1, X2, Y Y Z TIENEN LA SIGNIFICACION QUE ESTA EN LA DESCRIPCION. LA COMBINACION REPRESENTA VALIOSOS PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE LA QUINOLONA ACIDA CARBOXILICA EFICAZ Y ANTIBACTERIANO A TRAVES DEL PROCEDIMIENTO CIDOARACYL
ES87113034T 1986-09-19 1987-09-07 Procedimiento para la obtencion de derivados fluorados en el nucleo del acido benzoico. Expired - Lifetime ES2044886T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863631906 DE3631906A1 (de) 1986-09-19 1986-09-19 Verfahren zur herstellung von benzoesaeure-derivaten

Publications (1)

Publication Number Publication Date
ES2044886T3 true ES2044886T3 (es) 1994-01-16

Family

ID=6309936

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87113034T Expired - Lifetime ES2044886T3 (es) 1986-09-19 1987-09-07 Procedimiento para la obtencion de derivados fluorados en el nucleo del acido benzoico.

Country Status (22)

Country Link
US (2) US4851160A (es)
EP (1) EP0266512B1 (es)
JP (2) JPS6388157A (es)
KR (1) KR950008083B1 (es)
CN (1) CN1024415C (es)
AR (1) AR245438A1 (es)
AT (1) ATE70045T1 (es)
AU (1) AU600020B2 (es)
CA (1) CA1325018C (es)
DD (1) DD269146A5 (es)
DE (2) DE3631906A1 (es)
DK (2) DK168212B1 (es)
ES (1) ES2044886T3 (es)
FI (1) FI86843C (es)
GR (1) GR3003383T3 (es)
HU (1) HU197872B (es)
IE (1) IE60032B1 (es)
IL (1) IL83919A (es)
NO (1) NO166785C (es)
PH (2) PH25370A (es)
PT (1) PT85743B (es)
ZA (1) ZA877027B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782180A (en) * 1985-09-09 1988-11-01 Warner-Lambert Company Process for tetrafluorobenzoic acid
US4791225A (en) * 1986-01-20 1988-12-13 Kyorin Pharmaceutical Co., Ltd. Halogenobenzoic acid derivatives and their preparation
JP2552319B2 (ja) * 1987-02-13 1996-11-13 株式会社日本触媒 ３−アミノ−２，４，５−トリフルオロ安息香酸
US4782179A (en) * 1987-02-13 1988-11-01 Nippon Shokubai Kagaku Kogyo Co., Ltd. 3-amino-2,4,5-trifluorobenzoic acid and a method for manufacture thereof
JPH02746A (ja) * 1987-12-29 1990-01-05 Nippon Carbide Ind Co Inc ３−アミノ−２，４，５−トリフルオロ安息香酸及びその製造方法
US4885386A (en) * 1988-10-28 1989-12-05 Warner-Lambert Company Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid
JPH02215744A (ja) * 1989-02-15 1990-08-28 Sds Biotech Kk 安息香酸誘導体およびその製造方法
US5237086A (en) * 1989-09-02 1993-08-17 Bayer Aktiengesellschaft Fungicidal derivatives of carbocyclic anilides
US4935541A (en) * 1989-11-20 1990-06-19 Occidental Chemical Corporation Preparation of 2,4,5-trifluorobenzoic acid by decarboxylation of 3,4,6-trifluorophthalic anhydride
US5233083A (en) * 1991-08-16 1993-08-03 Hoechst Aktiengesellschaft Process for the preparation of 2-amino-3-chlorobenzoic acid
DE4409578A1 (de) * 1994-03-21 1995-09-28 Bayer Ag Verfahren zur Herstellung von 2-Halogen-4,5-difluorbenzoylfluoriden
DE69716962T2 (de) * 1996-08-19 2003-07-03 Ube Industries Verfahren zur herstellung von substituierten trifluorobenzoesäurederivaten und deren ester
DE19733243A1 (de) 1997-08-01 1999-02-04 Bayer Ag Verfahren zur Herstellung von 3-Cyano-2,4-dihalogen-5-fluor-benzoesäure
US6187931B1 (en) 1999-04-06 2001-02-13 Albemarle Corporation Process for making fluorophthalimides
US6677479B2 (en) * 2001-11-13 2004-01-13 Clariant Finance Lbvi Limited Substituted fluoroaromatics, process for preparing them and their use
CN1328238C (zh) * 2004-09-06 2007-07-25 大连绿源药业有限责任公司 2，4，5－三氟苯甲酸的制备方法
CN103102262A (zh) * 2013-01-18 2013-05-15 浙江华基生物技术有限公司 2,3,4,5,6-五氟苯甲酸的合成方法
CN103980113B (zh) * 2014-06-04 2016-05-25 国药集团化学试剂有限公司 一种4-溴代邻苯二甲酸的制备方法
CN105777548A (zh) * 2016-03-31 2016-07-20 常州大学 一种2，4，6-三氯-3-硝基苯甲酸的合成方法
CN106748721B (zh) * 2016-11-17 2019-06-21 山东铂源药业有限公司 一种2-氯-5-碘苯甲酸的制备方法
CN113912487B (zh) * 2021-11-23 2024-05-28 山东研峰新材料科技有限公司 一种2,5-双卤代苯甲酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB991537A (en) * 1963-02-18 1965-05-12 Bayer Ag Plant growth influencing compositions containing chlorobenzoic acid derivatives
CA1157884A (en) * 1980-04-16 1983-11-29 Byron R. Cotter Process for the preparation of trifluoromethylbenzoyl halides
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
DE3409244A1 (de) * 1984-03-14 1985-09-19 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von halogenanthranilsaeuren
DE3420796A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 2,4,5-trihalogen- bzw. 2,3,4,5-tetrahalogenbenzolderivate und verfahren zu ihrer herstellung
AU576272B2 (en) * 1984-11-13 1988-08-18 Kyorin Pharmaceutical Co. Ltd. Quinolone carboxylic acid derivates
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
US4791225A (en) * 1986-01-20 1988-12-13 Kyorin Pharmaceutical Co., Ltd. Halogenobenzoic acid derivatives and their preparation
JP2637399B2 (ja) * 1986-04-03 1997-08-06 キヤノン株式会社 消去装置
JP2552319B2 (ja) * 1987-02-13 1996-11-13 株式会社日本触媒 ３−アミノ−２，４，５−トリフルオロ安息香酸
US4885386A (en) * 1988-10-28 1989-12-05 Warner-Lambert Company Process for the synthesis of 3-chloro-2,4,5-trifluorobenzoic acid

Also Published As

Publication number Publication date
AR245438A1 (es) 1994-01-31
NO873689D0 (no) 1987-09-03
CN1024415C (zh) 1994-05-04
AU600020B2 (en) 1990-08-02
DD269146A5 (de) 1989-06-21
CA1325018C (en) 1993-12-07
DE3631906A1 (de) 1988-03-31
HU197872B (en) 1989-06-28
PH26462A (en) 1992-07-27
JPH0625125A (ja) 1994-02-01
DK170253B1 (da) 1995-07-17
US4851160A (en) 1989-07-25
KR950008083B1 (ko) 1995-07-25
AU7829087A (en) 1988-03-24
DK490287D0 (da) 1987-09-18
KR880003890A (ko) 1988-06-01
ZA877027B (en) 1988-03-23
PH25370A (en) 1991-05-13
JPH0694446B2 (ja) 1994-11-24
DK86193D0 (da) 1993-07-21
FI874063A (fi) 1988-03-20
US4990661A (en) 1991-02-05
IE60032B1 (en) 1994-05-18
EP0266512B1 (de) 1991-12-04
ATE70045T1 (de) 1991-12-15
GR3003383T3 (en) 1993-02-17
NO873689L (no) 1988-03-21
IL83919A (en) 1991-06-30
DK86193A (da) 1993-07-21
FI86843B (fi) 1992-07-15
FI86843C (fi) 1992-10-26
DK168212B1 (da) 1994-02-28
IE872533L (en) 1988-03-19
NO166785B (no) 1991-05-27
HUT45001A (en) 1988-05-30
PT85743A (en) 1987-10-01
EP0266512A3 (en) 1989-05-03
FI874063A0 (fi) 1987-09-17
DK490287A (da) 1988-03-20
JPH0576934B2 (es) 1993-10-25
JPS6388157A (ja) 1988-04-19
NO166785C (no) 1991-09-04
CN87106482A (zh) 1988-03-30
IL83919A0 (en) 1988-02-29
DE3775003D1 (de) 1992-01-16
EP0266512A2 (de) 1988-05-11
PT85743B (pt) 1990-06-29

Similar Documents

Publication Publication Date Title
ES2044886T3 (es) Procedimiento para la obtencion de derivados fluorados en el nucleo del acido benzoico.
ES2054995T3 (es) Nuevos derivados del acido benzoico y acido fenilacetico, su obtencion y empleo como medicamentos.
ES2090065T3 (es) Esteres de acido fosforico, procedimiento para su fabricacion y su utilizacion como agente dispersante.
ES538958A0 (es) Procedimiento para la obtencion de derivados del acido benzoico
ES2060883T3 (es) Procedimiento de obtencion del acido carnosico.
ES504388A0 (es) Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico.
HN1999000131A (es) Derivados del acido hidroxi pipecolato hidroxamico.
ES532342A0 (es) Procedimiento para preparar derivados del acido benzoico.
GT200000190A (es) Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas-4-carboxiamino-2-sustituidas.
ES549359A0 (es) Un procedimiento para la preparacion de nuevos derivados del acido (5-amino-2-hidroxi)benzoico.
IT1297038B1 (it) Procedimento per la preparazione di reina e suoi diacilderivati
ES557550A0 (es) Procedimiento para la obtencion del acido 1-ciclopropil-6-fluor-1,4-dihidro-7-(4-isopropil-1-piperazinil)-4-oxo-3-quinolincarboxilico
MX9304961A (es) Esteres del acido piridiloxi-acrilico y procedimiento para su obtencion.
ES2037824T3 (es) Un procedimiento para producir un derivado de acido bifosfonico.
AR226917A1 (es) Procedimiento para la produccion de derivados del acido quinolincarboxilico
ATE55981T1 (de) Phenylserin-derivate und verfahren zu ihrer herstellung.
ES528496A0 (es) Procedimiento para la obtencion de acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(4-(oxoalquil)-1-piperazinil)-3-quinolincarboxilico y sus derivados
ES2054738T3 (es) Derivados de acido 3-desmetil-4-fluoromevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su empleo y productos intermedios.
ES2046218T3 (es) Derivados de acidos piridin-2,4- y -2,5-dicarboxilicos, procedimientos para su produccion, aplicacion de los mismos asi como medicamentos a base de estos compuestos.
ES519743A0 (es) Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.
ES537480A0 (es) Procedimiento para la fabricacion de la reductasa del acido 2, 5-diceto-d-gluconico
ES2009758B3 (es) Procedimiento para la obtencion de clausenamida.
MX169465B (es) Procedimiento para la obtencion de derivados del acido pirimidilfosforico y productos intermedios
ES2061530T3 (es) 9-amino-1,4-etano-1,2,3,4-tetrahidroacridina y compuestos afines, intermediarios y un procedimiento para la preparacion de los mismos y su uso como medicamentos.
ATE270671T1 (de) Zwischenprodukte für die herstellung von naphthyridin-3-carbonsäure-derivaten

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 266512

Country of ref document: ES