ES2009758B3 - Procedimiento para la obtencion de clausenamida. - Google Patents
Procedimiento para la obtencion de clausenamida.Info
- Publication number
- ES2009758B3 ES2009758B3 ES86113940T ES86113940T ES2009758B3 ES 2009758 B3 ES2009758 B3 ES 2009758B3 ES 86113940 T ES86113940 T ES 86113940T ES 86113940 T ES86113940 T ES 86113940T ES 2009758 B3 ES2009758 B3 ES 2009758B3
- Authority
- ES
- Spain
- Prior art keywords
- clausenamide
- image
- procedure
- obtaining
- found
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Machine Translation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EN LA OXIDACION DE (+ -) 4(R*), 5(R*), 7(S*) -5 ALFAHIDROXIBENCIL -1METIL -4-FENILPIRROLIDIN -2-ONA (II) SE PRODUCE CLAUSENAMIDA. EL COMPUESTO II SE OBTIENE MEDIANTE UNA SINTESIS EN VARIAS ETAPAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853537075 DE3537075A1 (de) | 1985-10-18 | 1985-10-18 | Verfahren zur herstellung von clausenamid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2009758B3 true ES2009758B3 (es) | 1989-10-16 |
Family
ID=6283835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86113940T Expired ES2009758B3 (es) | 1985-10-18 | 1986-10-08 | Procedimiento para la obtencion de clausenamida. |
Country Status (9)
Country | Link |
---|---|
US (2) | US4731456A (es) |
EP (1) | EP0219055B1 (es) |
JP (1) | JPH0794430B2 (es) |
KR (1) | KR870003981A (es) |
CN (1) | CN1015710B (es) |
AT (1) | ATE43836T1 (es) |
CA (1) | CA1280427C (es) |
DE (2) | DE3537075A1 (es) |
ES (1) | ES2009758B3 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3717394A1 (de) * | 1987-05-23 | 1988-12-01 | Basf Ag | 3-phenyl-2-styryl-pyrrolidine, ihre herstellung und verwendung |
DE3717395A1 (de) * | 1987-05-23 | 1988-12-08 | Basf Ag | 5-phenyl-1,2,3a,4,5,9b-hexahydro-3h-benz(e) indole, ihre herstellung und verwendung als arzneimittel |
DE3927367A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von dehydrocycloclausenamid und dessen derivate in der racemischen form und als optisch aktive (+) oder (-)-enantiomere |
DE3927370A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Verfahren zur herstellung von clausenamid und neoclausenamid und deren derivate |
US5049578A (en) * | 1990-03-09 | 1991-09-17 | E. R. Squibb & Sons, Inc. | 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones |
US6486169B1 (en) * | 2002-02-19 | 2002-11-26 | Yaguang Liu | Botanical drug for treatment and prevention of alzhimer's disease |
US6787564B2 (en) * | 2002-03-26 | 2004-09-07 | Institute Of Materia Medica, Chinese Academy Of Medical Sciences | Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use |
CN102249976B (zh) * | 2011-06-10 | 2012-11-14 | 中国科学院化学研究所 | 一种光学纯的(-)-黄皮酰胺类化合物的制备方法 |
CN103285123B (zh) * | 2013-06-20 | 2015-04-22 | 广东医学院 | 黄皮果提取物在防治药源性肝炎药物中的应用 |
CN105017124A (zh) * | 2015-07-10 | 2015-11-04 | 广西师范大学 | 一种合成黄皮酰胺的新方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4119637A (en) * | 1975-09-23 | 1978-10-10 | A. H. Robins Company, Inc. | 4-Hydroxymethyl-2-pyrrolidinones |
AT374457B (de) * | 1977-08-18 | 1984-04-25 | Hoechst Ag | Verfahren zur herstellung von neuen benzolsulfonamidderivaten |
CH646149A5 (de) * | 1981-02-05 | 1984-11-15 | Hoffmann La Roche | Pyrrolidin-derivat. |
DE3346623A1 (de) * | 1983-12-14 | 1985-07-04 | Bayer Ag, 5090 Leverkusen | N-glycosylierte harnstoffe, carbamate und thiocarbamate, verfahren zu ihrer herstellung sowie ihre verwendung |
DE3508025A1 (de) * | 1985-03-07 | 1986-09-11 | Bayer Ag, 5090 Leverkusen | Substituierte o-sulfonyl-glycosylamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS61245607A (ja) * | 1985-04-24 | 1986-10-31 | Hitachi Ltd | 周波数復調回路 |
-
1985
- 1985-10-18 DE DE19853537075 patent/DE3537075A1/de not_active Withdrawn
-
1986
- 1986-10-03 US US06/915,309 patent/US4731456A/en not_active Expired - Lifetime
- 1986-10-08 ES ES86113940T patent/ES2009758B3/es not_active Expired
- 1986-10-08 DE DE8686113940T patent/DE3663809D1/de not_active Expired
- 1986-10-08 AT AT86113940T patent/ATE43836T1/de not_active IP Right Cessation
- 1986-10-08 EP EP86113940A patent/EP0219055B1/de not_active Expired
- 1986-10-16 CA CA000520591A patent/CA1280427C/en not_active Expired - Lifetime
- 1986-10-17 KR KR1019860008708A patent/KR870003981A/ko not_active Application Discontinuation
- 1986-10-17 JP JP61245606A patent/JPH0794430B2/ja not_active Expired - Lifetime
- 1986-10-18 CN CN86107090A patent/CN1015710B/zh not_active Expired
-
1987
- 1987-09-01 US US07/091,623 patent/US4751315A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE43836T1 (de) | 1989-06-15 |
CA1280427C (en) | 1991-02-19 |
EP0219055A1 (de) | 1987-04-22 |
CN1015710B (zh) | 1992-03-04 |
DE3537075A1 (de) | 1987-04-23 |
US4751315A (en) | 1988-06-14 |
DE3663809D1 (en) | 1989-07-13 |
JPS62187450A (ja) | 1987-08-15 |
US4731456A (en) | 1988-03-15 |
KR870003981A (ko) | 1987-05-06 |
JPH0794430B2 (ja) | 1995-10-11 |
EP0219055B1 (de) | 1989-06-07 |
CN86107090A (zh) | 1987-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX155769A (es) | Procedimiento para la obtencion de pigmentos de brillo nacarado con estabilidad mejorada | |
BR8604895A (pt) | Produto para higiene oral | |
IT8220264A1 (it) | Sintesi di carbonati di alcoli superiori e loro impiego come lubrificanti sintetici | |
ES552900A0 (es) | Procedimiento para la fabricacion de un compuesto alimenticio colorante | |
ES554127A0 (es) | Procedimiento para la sintesis de perfluoroalcanos y haloperfluoroalcanos. | |
ES552585A0 (es) | Procedimiento para la union quimica de compuestos de moldeo. | |
ES501418A0 (es) | Un procedimiento para la preparacion de espiro (ciclohexano-1,1'(3'h)-isobenzofuranos) | |
ES2009758B3 (es) | Procedimiento para la obtencion de clausenamida. | |
ES546625A0 (es) | Procedimiento para la sintesis de derivados de acidos omega-aminados | |
MX7527E (es) | Procedimiento para la sintesis de un aminoacido de ciclopropilo | |
ES554942A0 (es) | Procedimiento para la obtencion de nuevos compuestos de piridazinio | |
ES555804A0 (es) | Procedimiento para preparar sialosilcerebrosido gm4 | |
ES535624A0 (es) | Un procedimiento para la preparacion de 9-deoxo-9a-metil-9a-aza-9a-homoeritromicina b o una sal de la misma | |
AR222039A1 (es) | Amidas de acidos 1,2,3-triazol-carboxilicos,procedimientos para la produccion de estos compuestos y composiciones biocidas que los contienen | |
AR226180A1 (es) | Procedimiento para la sintesis de acido 4,4'-dinitroestilben-2,2'-disulfonico y sus sales | |
GR82125B (es) | ||
ES553986A0 (es) | Procedimiento para la obtencion de compuestos de heterociclil-penem | |
IT8049291A0 (it) | Procedimento per la depurazione di pentaeritritolo | |
ES266909Y (es) | "disposicion de cinta de soporte para cierres de cremallera". | |
ES513723A0 (es) | Un procedimiento para la preparacion de derivados de cistina". | |
ATE35981T1 (de) | Harnstoffacrylderivate. | |
IL71987A (en) | N-(beta-fluoroethyl)nortropine,its preparation and use in preparation of the corresponding 3-alpha-benzilate | |
AR225677A1 (es) | Procedimiento para la preparacion de n-(5-cloro-4-(fenil-ciano-metil)-fenil)-2-hidroxi-benzamidas | |
BR8603202A (pt) | Composicoes herbicidas a base de novos quinolino-8-acilazolidios,e,processo de obtencao destes compostos | |
IT7967132A0 (it) | Procedimento per la sintesi di 2benzensolfonamido 3 metossipirazina |