ES504388A0 - Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. - Google Patents

Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico.

Info

Publication number
ES504388A0
ES504388A0 ES504388A ES504388A ES504388A0 ES 504388 A0 ES504388 A0 ES 504388A0 ES 504388 A ES504388 A ES 504388A ES 504388 A ES504388 A ES 504388A ES 504388 A0 ES504388 A0 ES 504388A0
Authority
ES
Spain
Prior art keywords
procedure
preparation
hygroscopic salts
hydroxybutric acid
hydroxybutric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES504388A
Other languages
English (en)
Other versions
ES8306360A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803049869 external-priority patent/DE3049869A1/de
Application filed by Individual filed Critical Individual
Publication of ES8306360A1 publication Critical patent/ES8306360A1/es
Publication of ES504388A0 publication Critical patent/ES504388A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES504388A 1980-07-17 1981-07-16 Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. Granted ES504388A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3027390 1980-07-17
DE19803049869 DE3049869A1 (de) 1980-11-20 1980-11-20 Erdalkalisalze der 4-hydroxybuttersaeure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8306360A1 ES8306360A1 (es) 1983-06-01
ES504388A0 true ES504388A0 (es) 1983-06-01

Family

ID=25786727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504388A Granted ES504388A0 (es) 1980-07-17 1981-07-16 Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico.

Country Status (5)

Country Link
US (1) US4393236A (es)
EP (1) EP0044801B1 (es)
AU (1) AU7303981A (es)
DK (1) DK283081A (es)
ES (1) ES504388A0 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
ES2058023B1 (es) * 1992-10-29 1995-10-01 Koehler Chemie Dr Franz Derivados del acido 4-hidroxi-butirico.
GB2299992A (en) * 1995-04-20 1996-10-23 Willem Jacob Serfontein Complexes of magnesium and calcium
US6472431B2 (en) 1998-12-23 2002-10-29 Orphan Medical, Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
EP1316309A1 (en) * 1998-12-23 2003-06-04 Orphan Medical Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
CA2486557A1 (en) * 2002-06-13 2003-12-24 Novartis Ag Calcium salts of indole derived statins
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8410304B2 (en) * 2009-04-15 2013-04-02 Norac Pharma Process for preparing gamma-hydroxybutyrate
ES2433242T3 (es) 2009-04-23 2013-12-10 Concert Pharmaceuticals Inc. Análogos del ácido 4-hidroxibutírico
AU2011232408B2 (en) 2010-03-24 2015-07-30 Jazz Pharmaceuticals, Inc. Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances
MX355742B (es) 2011-02-14 2018-04-26 Concert Pharmaceuticals Inc Análogos deuterados del ácido 4-hidroxibutírico.
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US9050302B2 (en) 2013-03-01 2015-06-09 Jazz Pharmaceuticals Ireland Limited Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
EP3737353A1 (en) 2017-12-18 2020-11-18 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
JP2021506984A (ja) 2017-12-18 2021-02-22 トリス・フアルマ・インコーポレーテツド トリガーパルス薬物放出を有する胃内滞留型ｒａｆｔ形成システムを含む放出調節薬物粉末組成物
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
WO2019126216A1 (en) 2017-12-18 2019-06-27 Tris Phama, Inc. Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
BR112021006027A2 (pt) 2018-11-19 2021-06-29 Jazz Pharmaceuticals Ireland Limited formulações de fármaco resistente a álcool
CN109369372A (zh) * 2018-11-28 2019-02-22 上海欣海国际贸易有限公司 一种制备3-羟基丁酸盐的方法
WO2020178695A1 (en) 2019-03-01 2020-09-10 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
TW202139986A (zh) 2020-02-21 2021-11-01 愛爾蘭商爵士製藥愛爾蘭有限責任公司 治療原發性嗜睡症之方法
CN112778123A (zh) * 2021-01-19 2021-05-11 宁波酶赛生物工程有限公司 一种3-羟基丁酸钠晶型及其制备方法和应用
US20240182401A1 (en) * 2021-03-20 2024-06-06 Alkem Laboratories Limited A process for the preparation of mixed oxybate salts and polymorphs thereof
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
EP4658242A1 (en) 2023-02-03 2025-12-10 Tris Pharma, Inc. Low sodium oxybate once nightly composition

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA465270A (en) * 1950-05-23 Moore Kirk Philip Process for the preparation of pure calcium alpha hydroxyisobutyrate and pure alpha hydroxyisobutyric acid
GB922029A (en) * 1960-05-19 1963-03-27 Equilibre Biolog L Therapeutic composition

Also Published As

Publication number Publication date
ES8306360A1 (es) 1983-06-01
DK283081A (da) 1982-01-18
AU7303981A (en) 1982-01-21
EP0044801B1 (de) 1984-02-15
US4393236A (en) 1983-07-12
EP0044801A1 (de) 1982-01-27

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