ES8306360A1 - Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. - Google Patents

Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico.

Info

Publication number
ES8306360A1
ES8306360A1 ES504388A ES504388A ES8306360A1 ES 8306360 A1 ES8306360 A1 ES 8306360A1 ES 504388 A ES504388 A ES 504388A ES 504388 A ES504388 A ES 504388A ES 8306360 A1 ES8306360 A1 ES 8306360A1
Authority
ES
Spain
Prior art keywords
magnesium
calcium
hydroxy
manufacture
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504388A
Other languages
English (en)
Other versions
ES504388A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803049869 external-priority patent/DE3049869A1/de
Application filed by Individual filed Critical Individual
Publication of ES8306360A1 publication Critical patent/ES8306360A1/es
Publication of ES504388A0 publication Critical patent/ES504388A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE SALES NO HIGROSCOPICAS DEL ACIDO 4-HIDROXIBUTIRICO. CONSISTE EN DISOCIAR HIDROLITICAMENTE GAMMA-BUTIROLACTONA POR REACCION CON UN HIDROXIDO, OXIDO O CARBONATO DE CALCIO O DE MAGNESIO; LA REACCION TIENE LUGAR A TEMPERATURAS INFERIORES A 80 C. A CONTINUACION TIENE LUGAR LA RECRISTALIZACION DE LA MASA CRISTALINA. CUANDO LA REACCION SE EFECTUA CON HIDROXIDO, OXIDO O CARBONATO DE MAGNESIO, LA TEMPERATURA DE REACCION ES LA DE EBULLICION DE AGUA. SE OBTIENEN COMPUESTOS (I) EN QUE E ES CALCIO O MAGNESIO Y X ES 0, 4, 5 O 6 DE MODO QUE CUANDO E ES CALCIO, X ES 0.
ES504388A 1980-07-17 1981-07-16 Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico. Granted ES504388A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3027390 1980-07-17
DE19803049869 DE3049869A1 (de) 1980-11-20 1980-11-20 Erdalkalisalze der 4-hydroxybuttersaeure, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8306360A1 true ES8306360A1 (es) 1983-06-01
ES504388A0 ES504388A0 (es) 1983-06-01

Family

ID=25786727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504388A Granted ES504388A0 (es) 1980-07-17 1981-07-16 Procedimiento para la preparacion de sales no higroscopicas del acido 4-hidroxibutirico.

Country Status (5)

Country Link
US (1) US4393236A (es)
EP (1) EP0044801B1 (es)
AU (1) AU7303981A (es)
DK (1) DK283081A (es)
ES (1) ES504388A0 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058023A1 (es) * 1992-10-29 1994-10-16 Koehler Chemie Dr Franz Derivados del acido 4-hidroxi-butirico.

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
GB2299992A (en) * 1995-04-20 1996-10-23 Willem Jacob Serfontein Complexes of magnesium and calcium
ES2193777T3 (es) 1998-12-23 2003-11-01 Orphan Medical Inc Disoluciones estables e inalterables microbiologicamente de sal de gamma-hidroxibutirato para el tratamiento de la narcolepsia.
EP1316309A1 (en) * 1998-12-23 2003-06-04 Orphan Medical Inc. Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy
JP2005532362A (ja) * 2002-06-13 2005-10-27 ノバルティス アクチエンゲゼルシャフト インドール誘導スタチンのカルシウム塩
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
US8771735B2 (en) * 2008-11-04 2014-07-08 Jazz Pharmaceuticals, Inc. Immediate release dosage forms of sodium oxybate
US8778398B2 (en) 2008-11-04 2014-07-15 Jazz Pharmaceuticals, Inc. Immediate release formulations and dosage forms of gamma-hydroxybutyrate
US8410304B2 (en) * 2009-04-15 2013-04-02 Norac Pharma Process for preparing gamma-hydroxybutyrate
WO2010124046A1 (en) 2009-04-23 2010-10-28 Concert Pharmaceuticals, Inc. 4-hydroxybutyric acid analogs
MX2020011961A (es) 2010-03-24 2022-04-19 Jazz Pharmaceuticals Inc Formas de dosis de liberacion controlada para substancias de farmaco de alta dosis, solubles en agua e higroscopicas.
KR101976218B1 (ko) 2011-02-14 2019-05-07 콘서트 파마슈티컬즈, 인크. 4-히드록시부티르산 중수소화 유사체
US8591922B1 (en) 2012-12-14 2013-11-26 Jazz Pharmacuticals, Inc. Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
US9050302B2 (en) 2013-03-01 2015-06-09 Jazz Pharmaceuticals Ireland Limited Method of administration of gamma hydroxybutyrate with monocarboxylate transporters
US10398662B1 (en) 2015-02-18 2019-09-03 Jazz Pharma Ireland Limited GHB formulation and method for its manufacture
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US20180263936A1 (en) 2017-03-17 2018-09-20 Jazz Pharmaceuticals Ireland Limited Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
WO2019126215A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
EP3740189A1 (en) 2017-12-18 2020-11-25 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive raft forming systems having trigger pulse drug release
CN113395960A (zh) 2018-11-19 2021-09-14 爵士制药爱尔兰有限公司 抗酒精药物制剂
CN109369372A (zh) * 2018-11-28 2019-02-22 上海欣海国际贸易有限公司 一种制备3-羟基丁酸盐的方法
JP2022522270A (ja) 2019-03-01 2022-04-15 フラメル アイルランド リミテッド 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物
CN112778123A (zh) * 2021-01-19 2021-05-11 宁波酶赛生物工程有限公司 一种3-羟基丁酸钠晶型及其制备方法和应用
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA465270A (en) * 1950-05-23 Moore Kirk Philip Process for the preparation of pure calcium alpha hydroxyisobutyrate and pure alpha hydroxyisobutyric acid
GB922029A (en) * 1960-05-19 1963-03-27 Equilibre Biolog L Therapeutic composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058023A1 (es) * 1992-10-29 1994-10-16 Koehler Chemie Dr Franz Derivados del acido 4-hidroxi-butirico.

Also Published As

Publication number Publication date
EP0044801A1 (de) 1982-01-27
DK283081A (da) 1982-01-18
ES504388A0 (es) 1983-06-01
US4393236A (en) 1983-07-12
AU7303981A (en) 1982-01-21
EP0044801B1 (de) 1984-02-15

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