ES2037824T3 - Un procedimiento para producir un derivado de acido bifosfonico. - Google Patents

Un procedimiento para producir un derivado de acido bifosfonico.

Info

Publication number
ES2037824T3
ES2037824T3 ES198888302119T ES88302119T ES2037824T3 ES 2037824 T3 ES2037824 T3 ES 2037824T3 ES 198888302119 T ES198888302119 T ES 198888302119T ES 88302119 T ES88302119 T ES 88302119T ES 2037824 T3 ES2037824 T3 ES 2037824T3
Authority
ES
Spain
Prior art keywords
derivative
procedure
produce
biphosphonic acid
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888302119T
Other languages
English (en)
Inventor
Shuichi Sakamoto
Makoto Takeuchi
Yasuo Isomura
Kunihiro Niigata
Tetsushi Abe
Kousei Kawamuki
Masafumi Kudou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2037824T3 publication Critical patent/ES2037824T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DEL ACIDO BIOFOSFONICO DE FORMULA(I), Y A SUS SALES, QUE TIENEN ACTIVIDAD INHIBIDORA DE LA RESORCION DE LOS HUESOS Y ANTIARTRITICA.
ES198888302119T 1987-03-10 1988-03-10 Un procedimiento para producir un derivado de acido bifosfonico. Expired - Lifetime ES2037824T3 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP5491387 1987-03-10
JP24855587 1987-09-30
JP26509787 1987-10-19
JP26509887 1987-10-19
JP31152587 1987-12-08
JP31807787 1987-12-15
JP32764687 1987-12-24
JP32787987 1987-12-24

Publications (1)

Publication Number Publication Date
ES2037824T3 true ES2037824T3 (es) 1993-07-01

Family

ID=27572451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888302119T Expired - Lifetime ES2037824T3 (es) 1987-03-10 1988-03-10 Un procedimiento para producir un derivado de acido bifosfonico.

Country Status (9)

Country Link
US (1) US4973576A (es)
EP (1) EP0282320B1 (es)
KR (1) KR880011133A (es)
AU (1) AU607194B2 (es)
DE (1) DE3866737D1 (es)
DK (1) DK126888A (es)
ES (1) ES2037824T3 (es)
GR (1) GR3003476T3 (es)
HU (1) HU199151B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220021A (en) * 1989-04-03 1993-06-15 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
EP0466730B1 (en) * 1989-04-03 1993-07-21 The Upjohn Company Geminal bisphosphonic acids and derivatives as anti-arthritic agents
IE912115A1 (en) * 1990-06-25 1992-01-01 Takeda Chemical Industries Ltd Bisphosphonic acid derivatives, their production and use
ATE133677T1 (de) * 1990-12-19 1996-02-15 Takeda Chemical Industries Ltd Bisphosphonsäurederivate, ihre produktion und ihre verwendung
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
SE9402001D0 (sv) * 1994-06-09 1994-06-09 Leiras Oy Pyridylbisphosphonates for use as a therapeutical agent
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US6485740B1 (en) * 2000-03-14 2002-11-26 Yutoku Pharmaceutical Ind., Co., Ltd. Transdermal methotrexate preparations
JP4018417B2 (ja) * 2001-04-18 2007-12-05 株式会社東芝 光記録媒体および光記録装置
KR20120065435A (ko) 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
WO2003101462A2 (en) * 2002-05-31 2003-12-11 Københavns Universitet Use of bisphosphonic acid derivatives for the treatment of calcium phrophosphated deposition disease and dental treatment
US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5589293A (en) * 1978-12-28 1980-07-05 Nissan Chem Ind Ltd Bisphosphonic acid compound and herbicide consisting of it as active ingredient
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
EP0274347A1 (de) * 1986-11-24 1988-07-13 Feller Ag Störschutzfilter für eine Wechselstrom-Netzleitung

Also Published As

Publication number Publication date
AU1289788A (en) 1988-09-08
GR3003476T3 (en) 1993-02-17
DE3866737D1 (de) 1992-01-23
KR880011133A (ko) 1988-10-26
EP0282320A1 (en) 1988-09-14
DK126888A (da) 1988-09-11
HU199151B (en) 1990-01-29
US4973576A (en) 1990-11-27
HUT46700A (en) 1988-11-28
AU607194B2 (en) 1991-02-28
DK126888D0 (da) 1988-03-09
EP0282320B1 (en) 1991-12-11

Similar Documents

Publication Publication Date Title
ES2037824T3 (es) Un procedimiento para producir un derivado de acido bifosfonico.
ES2054860T3 (es) Nuevos derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion, asi como a su utilizacion como medicamentos.
ES2087107T3 (es) Sulfonilaminocarboniltriazolinonas.
AR004087A1 (es) Derivado del acido fenilacetico, procedimientos y productos intermedios para su obtencion y las composiciones que los contienen
ES2062943B1 (es) Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
ES2111092T3 (es) Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos.
ES2064101T3 (es) Compuestos de acido bencilfosfonico inhibidores de la quinasa de tirosina.
ES2159851T3 (es) Amidas de acidos aminotiofenocarboxilicos y su empleo como inhibidores de la fosfodiestearasa.
ES2053778T3 (es) Procedimiento para la obtencion de derivados del tiazol.
ES2020974B3 (es) Medicamente conteniendo dipiridamol o mopidamol y o-acido acetilsalicilico o sus sales tratables fisiologicamente, procedimiento para su fabricacion y su utilizacion para combatir la formacion de trombos
ES2136037B1 (es) Inhibidores de sulfamida-metaloproteasa
ES2100314T3 (es) Derivados de la pirimidina, su procedimiento de preparacion, productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que las contienen.
ES2032394T3 (es) Procedimiento para preparar derivados de tienoimidazol sustituidos.
ES2029842T3 (es) Procedimiento para preparar un derivado de quinolina.
ES2189365T3 (es) Nuevos derivados de eritromicina, su procedimiento de preparacion y su aplicacion como medicamentos.
ES2159734T3 (es) Derivados 2-heteroarilalquenilicos del acido ciclopentano-heptan(en)oico como agentes terapeuticos para el tratamiento de la hipertension ocular.
AR241246A1 (es) Procedimiento para la obtencion de nuevas sales de gentamicina, derivadas de la flavonona.
ES2041705T3 (es) Procedimiento para la preparacion de 1-(4-hidroxi-3,5-di-terc-butil-benzoil)-homopiperazina y sus derivados.
ECSP930981A (es) Derivados de benzotiazol que tengan un substituto de difluorobuteniltio
ES2040366T3 (es) Procedimiento de preparacion de nuevos derivados de 1-(bencilpiperidino)2-propanol.
ES2038679T3 (es) Un procedimiento para preparar derivados de dihidrobenzofurano- y cromano-carboxamidas.
ES2190471T3 (es) Procedimiento para producir derivados de guanidina, intermedios de dichos compuestos y su produccion.
MX9301404A (es) Derivados de 2-oxoquinolina, procedimiento para su preparacion, preparado farmaceutico que los contiene y procedimiento para la obtencion de tal preparado farmaceutico.
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
ES2052009T3 (es) Compuestos ciclicos que contienen azufre.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 282320

Country of ref document: ES