KR940009174A - 삼치환된 비페닐 - Google Patents

삼치환된 비페닐 Download PDF

Info

Publication number
KR940009174A
KR940009174A KR1019930021987A KR930021987A KR940009174A KR 940009174 A KR940009174 A KR 940009174A KR 1019930021987 A KR1019930021987 A KR 1019930021987A KR 930021987 A KR930021987 A KR 930021987A KR 940009174 A KR940009174 A KR 940009174A
Authority
KR
South Korea
Prior art keywords
carboxyl
trisubstituted
alkyl
straight
branched
Prior art date
Application number
KR1019930021987A
Other languages
English (en)
Other versions
KR100304225B1 (ko
Inventor
드레쎌 위르겐
페이 페테르
한코 루돌프
휘프쉬 발터
크래머 토마스
에. 묄러 올이히
묄러-글리만 마티아스
보익 마르틴
카즈다 스타니슬라프
볼파일 스테판
크노르 안드레아스
스타쉬 요하네스-페테르
자이쓰 지그프리트
Original Assignee
크누트 사우에르테, 클라우스 데너
바이엘 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 크누트 사우에르테, 클라우스 데너, 바이엘 악티엔게젤샤프트 filed Critical 크누트 사우에르테, 클라우스 데너
Publication of KR940009174A publication Critical patent/KR940009174A/ko
Application granted granted Critical
Publication of KR100304225B1 publication Critical patent/KR100304225B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

본 발명은 비페닐메틸 할로겐 화합물과 대응 피리돈의 반응에 의해 제조되는 삼치환된 비페닐 및 그의 염에 관한 것이다. 삼치환된 비페닐은 의약 활설 화합물로서 사용될 수 있다.

Description

삼치환된 비페닐
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(Ⅰ)의 삼치환된 비페닐 및 그의 염.
    식 중, R1은 카르복실기 또는 C1-C8-알콕시카르보닐기를 나타내고, R2는 직쇄 또는 분지쇄 C1-C8-알킬을 나타내고, R3은 할로겐, 히드록실, 시아노, C1-C6-알콕시, 직쇄 또는 분지쇄 C1-C8-알킬, 트리플루오로메틸, 트리플루오로메톡시, 카르복스아미도, 카르복실, C1-C8-알콕시카르보닐 또는 니트로를 나타내고, R4는 카르복실기 또는 테트라졸릴을 나타낸다.
  2. 제1항에 있어서, R1이 카르복실기 또는 C1-C6-알콕시카르보닐기를 나타내고, R2가 직쇄 또는 분지쇄 C1-C6-알킬을 나타내고, R3이 불소, 염소, 브롬, 히드록실, 시아노, C1-C4-알콕시, 직쇄 또는 분지쇄 C1-C4-알킬, 트리플루오로메틸, 트리플루오로메톡시, 카르복스아미도, 카르복실, C1-C6-알콕시카르보닐 또는 니트로를 나타내고, R4는 테트라졸릴을 나타내는 삼치환된 비페닐 및 그의 염.
  3. 제1항에 있어서, R1이 카르복실기 또는 C1-C4-알콕시카르보닐기를 나타내고, R2가 직쇄 또는 분지쇄 C1-C5-알킬을 나타내고, R3이 불소, 염소, 히드록실, 시아노, C1-C3-알콕시, 직쇄 또는 분지쇄 C1-C4-알킬, 트리플루오로메틸, 트리플루오로메톡시, 카르복스아미도, 카르복실, C1-C6-알콕시카르보닐 또는 니트로를 나타내고, R4는 테트라졸릴을 나타내는 삼치환된 비페닐 및 그의 염.
  4. 제1항에 있어서, R1이 카르복실, 메톡시카르보닐 또는 에톡시카르보닐을 나타내고, R2가 프로필, 부틸 또는 펜틸을 나타내고, R3이 불소, 염소, 히드록실, 시아노, 메틸, 메톡시, 에톡시, 에틸, 트리플루오로메틸, 트리플루오로메톡시, 카르복스아미도, 카르복실, 메톡시카르보닐, 에톡시카르보닐 또는 니트로를 나타내고, R4가 테트라졸을 나타내는 삼치화된 비페닐 및 그의 염.
  5. 제1항에 있어서, 치료용인 삼치환된 비페닐.
  6. [A] 하기 일반식(Ⅱ)의 피리돈을 비활성 용매 중에서 염기의 존재 하에, 필요하다면 촉매 첨가 하에 하기 일반식(Ⅲ)의 화합물과 반응시키거나, 또는 [B]R4가 테트라졸릴을 나타내는 경우에, 하기 일반식(Ⅳ)의 화합물을 비활성 용매 중에서 염기의 존재 하에, 금속 촉매 작용 하에 하기 일반식(Ⅴ)의 화합물과 반응시키고, 이어서, 유리 테트라졸(R4/T)의 경우에는 트리페닐메틸기를 유기 용매 및(또는) 물 중의 산으로 제거하고, 카르복실산(R4/R1)의 경우에는 대응 에스테르를 가수분해시켜 제조하며, 필요하다면 삼치환된 비페닐을 염기를 사용하여 그의 염으로 전환시키는 것을 특징으로 하는 제1항에 따른 삼치환된 비페닐 및 그의 염의 제조 방법.
    상기 각 식에서, R1, R2및 R3은 제1항에서 정의한 바와 같고, R4는 C1-C6-알콕시카르보닐 또는을 나타내고, E는 염소 또는 브롬을 나타내고, L은 전형적인 이탈기, 예를 들면 브롬, 요오드 또는 메탄-, 톨루엔-, 불소- 또는 트리플루오로메탄술포닐옥시, 바람직하게는 브롬을 나타내고, T는 수소 또는 트리패닐메틸기를 나타낸다.
  7. 제1항에 따른 삼치환된 비페닐을 적어도 1종 함유하는 의약.
  8. 제7항에 있어서, 고혈압 및 아테롬성 동맥경화증 치료를 위한 것인 의약.
  9. 의약 제조를 위한 제1항에 따른 삼치환된 비페닐의 용도.
  10. 제9항에 있어서, 항고혈압제 및 아테롬성 동맥경화제 제조를 위한 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930021987A 1992-10-23 1993-10-22 삼치환된비페닐 KR100304225B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4235933 1992-10-23
DEP4235933.3P 1992-10-23
DEP4235933.3 1992-10-23
DEP4319041.3 1993-06-08
DE4319041A DE4319041A1 (de) 1992-10-23 1993-06-08 Trisubstituierte Biphenyle

Publications (2)

Publication Number Publication Date
KR940009174A true KR940009174A (ko) 1994-05-20
KR100304225B1 KR100304225B1 (ko) 2004-05-10

Family

ID=25919778

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930021987A KR100304225B1 (ko) 1992-10-23 1993-10-22 삼치환된비페닐

Country Status (22)

Country Link
US (2) US5596006A (ko)
EP (1) EP0594019B1 (ko)
JP (1) JPH06199838A (ko)
KR (1) KR100304225B1 (ko)
CN (1) CN1040435C (ko)
AT (1) ATE189893T1 (ko)
AU (1) AU670315B2 (ko)
CA (1) CA2108814A1 (ko)
CZ (1) CZ283482B6 (ko)
DE (2) DE4319041A1 (ko)
DK (1) DK0594019T3 (ko)
ES (1) ES2145021T3 (ko)
FI (1) FI934646A (ko)
GR (1) GR3033207T3 (ko)
HU (1) HUT65819A (ko)
IL (1) IL107333A (ko)
MX (1) MX9306419A (ko)
NO (1) NO304651B1 (ko)
NZ (1) NZ250002A (ko)
PT (1) PT594019E (ko)
SK (1) SK279675B6 (ko)
TW (1) TW248555B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11600807B2 (en) 2018-08-20 2023-03-07 Samsung Display Co., Ltd. Method of manufacturing a display apparatus

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
EP1465869B1 (en) * 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
ES2251292B1 (es) * 2004-04-20 2007-07-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis.
WO2006130901A1 (en) * 2005-06-07 2006-12-14 Bayer Healthcare Ag Control of metabolic abnormalities
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
LT2847228T (lt) 2012-05-10 2018-11-12 Bayer Pharma Aktiengesellschaft Antikūnai, galintys jungtis prie koaguliacijos faktoriaus xi ir (arba) jo aktyvuotos formos faktoriaus xia, ir jų panaudojimas

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3800785A1 (de) * 1988-01-09 1989-07-20 Hoechst Ag Substituierte 7-(pyridazin-5-yl)-3,5-dihydroxyheptan(en)- saeuren, ihre entsprechenden (delta)-lactone bzw. derivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
ATE190051T1 (de) * 1989-06-14 2000-03-15 Smithkline Beecham Corp Imidazoalkensäure
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0485410A1 (en) * 1989-07-06 1992-05-20 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern A detector for monitoring low molecular weight compounds
AU640417B2 (en) * 1989-10-25 1993-08-26 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles
DE69030622T2 (de) * 1989-12-25 1997-08-14 Nippon Steel Corp Blech aus einer intermetallischen titan-aluminiumverbimdung und verfahren zu ihrer herstellung
EP0453210A3 (en) * 1990-04-19 1993-01-13 Imperial Chemical Industries Plc Pyridine derivatives
WO1991019697A1 (en) * 1990-06-19 1991-12-26 Meiji Seika Kabushiki Kaisha Pyridine derivative with angiotensin ii antagonism
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
ES2203614T3 (es) * 1991-11-18 2004-04-16 E.I. Du Pont De Nemours And Company Intermedios de acido tetrazolilfenilboronico para la sintesis de antagonistas de los receptores de aii.
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11600807B2 (en) 2018-08-20 2023-03-07 Samsung Display Co., Ltd. Method of manufacturing a display apparatus

Also Published As

Publication number Publication date
EP0594019B1 (de) 2000-02-23
NO304651B1 (no) 1999-01-25
MX9306419A (es) 1994-05-31
CZ283482B6 (cs) 1998-04-15
CN1040435C (zh) 1998-10-28
DK0594019T3 (da) 2000-07-03
AU4754193A (en) 1994-05-05
PT594019E (pt) 2000-08-31
HUT65819A (en) 1994-07-28
US5863930A (en) 1999-01-26
NO933591D0 (no) 1993-10-07
ES2145021T3 (es) 2000-07-01
FI934646A (fi) 1994-04-24
AU670315B2 (en) 1996-07-11
JPH06199838A (ja) 1994-07-19
EP0594019A1 (de) 1994-04-27
KR100304225B1 (ko) 2004-05-10
SK279675B6 (sk) 1999-02-11
HU9302997D0 (en) 1994-01-28
US5596006A (en) 1997-01-21
ATE189893T1 (de) 2000-03-15
NZ250002A (en) 1995-03-28
FI934646A0 (fi) 1993-10-21
CN1089260A (zh) 1994-07-13
TW248555B (ko) 1995-06-01
CZ221793A3 (en) 1994-05-18
DE4319041A1 (de) 1994-04-28
IL107333A0 (en) 1994-01-25
NO933591L (no) 1994-04-25
GR3033207T3 (en) 2000-08-31
SK116993A3 (en) 1994-11-09
IL107333A (en) 1998-01-04
DE59309956D1 (de) 2000-03-30
CA2108814A1 (en) 1994-04-24

Similar Documents

Publication Publication Date Title
KR940009174A (ko) 삼치환된 비페닐
DE3770095D1 (de) Chinazolindione und pyridopyrimidindione.
ES2167043T3 (es) Preparacion bifasica de esteres de acidos carboxilicos.
HK1006967A1 (en) Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation
KR860008176A (ko) 8-페닐크산틴류의 제조방법
DE3776520D1 (de) Oxidierte analoge von 17-beta-n-monosubstituierten carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
GB0005477D0 (en) Process for the preparation of citalopram
AU4765796A (en) Imidazolidinone derivatives as corrosion inhibitors
AU2002215930A1 (en) A process for the preparation of bis-benzazolyl compounds
ES2156955T3 (es) Procedimiento para la preparacion de 5-hidroximetiltiazol.
WO1999033788A3 (de) Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen
AU1524201A (en) Method for producing o-chloromethyl benzoic acid chlorides
KR960029345A (ko) 트리플루오로메틸-치환된 2-아자비시클로옥탄을 함유하는 신규 아실화 슈도펩티드
AU5110293A (en) Process for the stereoselective synthesis of 3-substituted 2-thiomethyl propionic acids
ES2020146A6 (es) Procedimiento de obtencion del acido 2-(2, 6-diclorofenil)amino) fenilacetoxiacetico.
DE69412094D1 (de) Herstellung von gemischen von estern der (r)- und (s)-2-(4-alkanylphenoxy)-oder (r)- und (s)-2-(4-aroylphenoxy)propansäure
EP0792936A3 (en) Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol
FI881254A (fi) Foerfarande foer framstaellning av klorade olefiner.
KR910002847A (ko) 설파모일티오펜, 이의 제조방법 및 이의 용도
DE60013957D1 (de) Verfahren zur Herstellung von Vinylpyrimidinderivaten
CA2099576A1 (en) Process for Producing 2-(Dialkyloxy Methyl)-Carboxyli c Acid Esters
KR970074734A (ko) 광학활성을 갖는 α-아릴카르복시산 유도체의 제조방법
KR970042548A (ko) 이미다조 피리딘 유도체,이의 제조방법 및 이를 함유한 약제학적 조성물
JPS6434976A (en) Gamma-lactonecarboxylic acid derivative and production thereof
KR950003285A (ko) 로메플록사신 및 그 염의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
AMND Amendment
J201 Request for trial against refusal decision
B701 Decision to grant
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee