WO1999033788A3 - Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen - Google Patents

Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen Download PDF

Info

Publication number
WO1999033788A3
WO1999033788A3 PCT/EP1998/008483 EP9808483W WO9933788A3 WO 1999033788 A3 WO1999033788 A3 WO 1999033788A3 EP 9808483 W EP9808483 W EP 9808483W WO 9933788 A3 WO9933788 A3 WO 9933788A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
biphenyl compounds
carboxylic acid
producing aromatic
bromomethyl biphenyl
Prior art date
Application number
PCT/EP1998/008483
Other languages
English (en)
French (fr)
Other versions
WO1999033788A2 (de
Inventor
Bernd Lehmann
Original Assignee
Great Lakes Chem Konstanz Gmbh
Bernd Lehmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Great Lakes Chem Konstanz Gmbh, Bernd Lehmann filed Critical Great Lakes Chem Konstanz Gmbh
Publication of WO1999033788A2 publication Critical patent/WO1999033788A2/de
Publication of WO1999033788A3 publication Critical patent/WO1999033788A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von aromatischen Brommethylbiphenyl-Verbindungen der Formel (II), in der R eine Carbonsäuregruppe, eine Cyangruppe, eine Carbonsäureamidgruppe, eine Carbonsäureestergruppe oder eine Tetrazolylgruppe, die substituiert sein kann, bedeutet, umfassend die Umsetzung der entsprechenden Methylbiphenyl-Verbindung mit Bromwasserstoff und Wasserstoffperoxid in Gegenwart eines Radikalstarters und/oder Licht. Das Verfahren liefert die Brommethylbiphenyl-Verbindungen der Formel (II) mit hoher Ausbeute und Selektivität, führt im großtechnischen Maßstab zu den Produkten und zeichnet sich durch eine hervorragende Umweltverträglichkeit aus.
PCT/EP1998/008483 1997-12-29 1998-12-28 Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen WO1999033788A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19757995.7 1997-12-29
DE19757995A DE19757995A1 (de) 1997-12-29 1997-12-29 Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen

Publications (2)

Publication Number Publication Date
WO1999033788A2 WO1999033788A2 (de) 1999-07-08
WO1999033788A3 true WO1999033788A3 (de) 1999-09-02

Family

ID=7853462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008483 WO1999033788A2 (de) 1997-12-29 1998-12-28 Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen

Country Status (2)

Country Link
DE (1) DE19757995A1 (de)
WO (1) WO1999033788A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2364277A1 (en) 2001-12-05 2003-06-05 Ioan A. Sabau Method and apparatus for decreasing gassing and decay of insulating oil in transformers
AU2002354446A1 (en) 2002-06-12 2003-12-31 Sumitomo Chemical Company, Limited Process for producing 4'-bromomethyl-2-cyanobiphenyl
CN1976926A (zh) 2004-09-02 2007-06-06 特瓦制药工业有限公司 奥美沙坦酯的制备
CN101094850A (zh) 2005-01-03 2007-12-26 特瓦制药工业有限公司 具有较低水平杂质的奥美沙坦酯
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
CN101597243B (zh) * 2009-06-26 2012-11-21 凯莱英生命科学技术(天津)有限公司 一种2-氰基-4’-溴甲基联苯的合成方法
CN111974325A (zh) * 2020-08-13 2020-11-24 浙江金立源药业有限公司 管道化合成对溴代甲基联苯甲酸甲酯的方法及其反应装置
CN111960967A (zh) * 2020-08-13 2020-11-20 浙江金立源药业有限公司 一种合成对溴代甲基联苯甲腈的连续流方法及其反应装置
CN114426501A (zh) * 2021-12-23 2022-05-03 山东艾孚特科技有限公司 基于水相反应的溴代沙坦联苯的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336567A1 (de) * 1988-03-19 1989-10-11 Solvay Interox Limited Verfahren zur Bromierung von Alkylarenen
JPH02221233A (ja) * 1989-02-23 1990-09-04 Sanko Kagaku Kogyo Kk 芳香核に結合するメチル基の臭素化方法
EP0553879A2 (de) * 1992-01-31 1993-08-04 Takeda Chemical Industries, Ltd. Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen
EP0709369A1 (de) * 1994-10-27 1996-05-01 SUMIKA FINE CHEMICALS Co., Ltd. Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl
WO1998046562A1 (en) * 1997-04-11 1998-10-22 Istituto Luso Farmaco D'italia S.P.A. A process for the preparation of 4-bromomethyl diphenyl compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336567A1 (de) * 1988-03-19 1989-10-11 Solvay Interox Limited Verfahren zur Bromierung von Alkylarenen
JPH02221233A (ja) * 1989-02-23 1990-09-04 Sanko Kagaku Kogyo Kk 芳香核に結合するメチル基の臭素化方法
EP0553879A2 (de) * 1992-01-31 1993-08-04 Takeda Chemical Industries, Ltd. Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen
EP0709369A1 (de) * 1994-10-27 1996-05-01 SUMIKA FINE CHEMICALS Co., Ltd. Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl
WO1998046562A1 (en) * 1997-04-11 1998-10-22 Istituto Luso Farmaco D'italia S.P.A. A process for the preparation of 4-bromomethyl diphenyl compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 014, no. 531 (C - 0780) 21 November 1990 (1990-11-21) *

Also Published As

Publication number Publication date
WO1999033788A2 (de) 1999-07-08
DE19757995A1 (de) 1999-07-08

Similar Documents

Publication Publication Date Title
DK0668272T3 (da) Fremgangsmåde til fremstilling af tetrazolylforbindelser
AU669782B2 (en) 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors
WO1999033788A3 (de) Verfahren zur herstellung von aromatischen brommethylbiphenyl-verbindungen
IL67445A (en) Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
EA200200481A1 (ru) Способ получения производных 4-трифторметилсульфинилпиразола
EP1314712A4 (de) Substituierte benzoesäurederivate als nf-kappa-b-inhibitoren
EP0711762A4 (de) Verfahren zur herstellung von tetrazol-verbindungen und darin verwendbare zwischenprodukte
EP0553879A3 (en) Process for producing 4-bromomethylbiphenyl compounds
TW239133B (de)
ATE309992T1 (de) Verfahren zur herstellung von bis-benzazolyl verbindungen
PT98518A (pt) Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase
US5629426A (en) Carbonate-mediated hydrogen peroxide oxidations of 4-hydroxy-2,2,6,6-tetramethylpiperidine
BG103651A (en) Compounds and methods for the preparation of substituted 4-phenyl-4-cyanocyclohexanoic acids
DK0897924T3 (da) Fremgangsmåde til fremstilling af tetrahydroindoliziner
MXPA05000054A (es) Proceso para la preparacion de compuestos de felil pirazol.
PL1670743T3 (pl) Sposób wytwarzania optycznie czystych związków kwasu-2-(4-hydroksyfenoksy)propionowego
CA2021328A1 (en) Stereoselective preparation of z-1,2-diarylallyl chlorides and the conversion thereof into azolylmethyloxiranes and novel intermediates
AU1762695A (en) Method for the preparation of organic compounds
EP0519083A4 (en) Process for producing hexahydropyridazine-1,2-dicarboxylic acid derivative
WO2003029189A1 (en) Process for producing (2-nitrophenyl)acetonitrile derivative and intermediate therefor
AU2003228104A1 (en) Process for producing aromatic compounds by friedel-crafts reaction
IL137027A (en) Process for the preparation of cyclopropane carboxylic acids
DK0638554T3 (da) Fremgangsmåde til fremstilling af et N-phenyl-N-(4-piperidinyl)amidderivat
PT798297E (pt) "processo para a producao de 2-alcoxi-6-(trifluorometil)-pirimidin-4-ol"
WO1999003814A3 (de) Verfahren zur herstellung von 3-hydroxy-2-methylbenzoesäure

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase