PT98518A - Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase - Google Patents

Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase

Info

Publication number
PT98518A
PT98518A PT98518A PT9851891A PT98518A PT 98518 A PT98518 A PT 98518A PT 98518 A PT98518 A PT 98518A PT 9851891 A PT9851891 A PT 9851891A PT 98518 A PT98518 A PT 98518A
Authority
PT
Portugal
Prior art keywords
steroids
delta
amino
da5alfa
redutase
Prior art date
Application number
PT98518A
Other languages
English (en)
Other versions
PT98518B (pt
Inventor
Thomas Robert Blohm
Joseph Paul Burkhart
Philip Marvin Weintraub
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/671,555 external-priority patent/US5143909A/en
Priority claimed from US07/720,900 external-priority patent/US5120840A/en
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT98518A publication Critical patent/PT98518A/pt
Publication of PT98518B publication Critical patent/PT98518B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT98518A 1990-08-01 1991-07-31 Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase PT98518B (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56104190A 1990-08-01 1990-08-01
US07/671,555 US5143909A (en) 1991-03-19 1991-03-19 Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,900 US5120840A (en) 1990-08-01 1991-07-02 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Publications (2)

Publication Number Publication Date
PT98518A true PT98518A (pt) 1992-06-30
PT98518B PT98518B (pt) 1999-01-29

Family

ID=27415841

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98518A PT98518B (pt) 1990-08-01 1991-07-31 Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase

Country Status (17)

Country Link
EP (1) EP0469548B1 (pt)
JP (1) JP3021819B2 (pt)
KR (1) KR100186812B1 (pt)
AT (1) ATE138931T1 (pt)
AU (1) AU637247B2 (pt)
CA (1) CA2048242C (pt)
DE (1) DE69119992T2 (pt)
DK (1) DK0469548T3 (pt)
ES (1) ES2090184T3 (pt)
FI (1) FI102377B (pt)
GR (1) GR3020672T3 (pt)
HU (1) HU210046B (pt)
IE (1) IE75198B1 (pt)
IL (1) IL98999A (pt)
NO (1) NO180339C (pt)
NZ (1) NZ239142A (pt)
PT (1) PT98518B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
EP0641356B1 (en) * 1991-12-20 1998-04-22 Glaxo Wellcome Inc. Inhibitors of 5-alpha-testosterone reductase
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5356935A (en) * 1993-12-13 1994-10-18 Eli Lilly And Company Reduced phenanthrenes
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2010091306A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
EP2968370A4 (en) 2013-03-14 2016-09-21 Univ Maryland AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
EP3033088A4 (en) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780070A (en) * 1972-09-21 1973-12-18 Schering Corp 4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives

Also Published As

Publication number Publication date
FI913657A0 (fi) 1991-07-31
HUT59156A (en) 1992-04-28
NZ239142A (en) 1994-05-26
ATE138931T1 (de) 1996-06-15
FI102377B1 (fi) 1998-11-30
JPH06172379A (ja) 1994-06-21
NO180339B (no) 1996-12-23
HU210046B (en) 1995-01-30
CA2048242C (en) 2003-04-15
NO180339C (no) 1997-04-02
EP0469548B1 (en) 1996-06-05
IL98999A (en) 1995-10-31
GR3020672T3 (en) 1996-10-31
ES2090184T3 (es) 1996-10-16
JP3021819B2 (ja) 2000-03-15
DK0469548T3 (da) 1996-06-24
AU8136291A (en) 1992-02-06
AU637247B2 (en) 1993-05-20
EP0469548A2 (en) 1992-02-05
DE69119992D1 (de) 1996-07-11
FI102377B (fi) 1998-11-30
DE69119992T2 (de) 1997-02-06
IE75198B1 (en) 1997-08-27
CA2048242A1 (en) 1992-02-02
FI913657A7 (fi) 1992-02-02
IE912705A1 (en) 1992-02-12
NO912981L (no) 1992-02-03
IL98999A0 (en) 1992-07-15
EP0469548A3 (en) 1992-06-03
HU912558D0 (en) 1992-01-28
KR100186812B1 (ko) 1999-04-01
PT98518B (pt) 1999-01-29
NO912981D0 (no) 1991-07-31
KR920004409A (ko) 1992-03-27

Similar Documents

Publication Publication Date Title
MX9200817A (es) Derivados de piranil cianoguanidina y proceso para su preparacion.
ES477695A1 (es) Un procedimiento para preparar derivados de deshidrociclici-minoacidos.
PT97796A (pt) Processo para a preparacao de piperidinas substituidas
ATE240305T1 (de) Verfahren zur herstellung von 2- hydroxybenzamidderivaten
PT92307A (pt) Processo para a preparacao de derivados de 3,5-dimetil-4-metoxipiridina e de produtos intermediarios
FI913657A0 (fi) 4-amino-d4-steroider och deras anvaendning som 5a-reduktasinhibitorer.
PT98519A (pt) Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase
DK0782996T3 (da) Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
EP0598910A4 (en) METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVES.
AU568064B2 (en) 4-acylamino-1-aza-adamantanes
BG103651A (en) Compounds and methods for the preparation of substituted 4-phenyl-4-cyanocyclohexanoic acids
DK305184D0 (da) Hexahydropyrrolo(2,1-a)isoquinolin-derivater
ES2193140T3 (es) Procedimiento para la produccion de 3-vinilcefalosporinas.
BR9405186A (pt) Processo para a preparação de 2,4,5-tribromopirrol-3-carbonitrila
DK159432C (da) Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
BR8900601A (pt) Processo para a preparacao de compostos de 1,2-dissulfona
BR9405262A (pt) Processo para a preparação de um ácido piridina-2,3-dicarboxílico
ES2030974T3 (es) Proceso de preparado de sustitutos de guaniltioureas.
FI851073L (fi) Inhibitor foer dopamin- -hydroxylas.
FI944967L (fi) Menetelmiä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten ja niiden välituotteiden valmistamiseksi
IT8622821A0 (it) Processo migliorato per lapreparazione di ossammidi utili quali stabilizzanti di composti organici.

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920204

FG3A Patent granted, date of granting

Effective date: 19981009

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040430