DE69119992D1 - 4-Amino-delta4-Steroide und ihre Verwendung als Inhibitoren von 5alpha-Reduktase - Google Patents

4-Amino-delta4-Steroide und ihre Verwendung als Inhibitoren von 5alpha-Reduktase

Info

Publication number
DE69119992D1
DE69119992D1 DE69119992T DE69119992T DE69119992D1 DE 69119992 D1 DE69119992 D1 DE 69119992D1 DE 69119992 T DE69119992 T DE 69119992T DE 69119992 T DE69119992 T DE 69119992T DE 69119992 D1 DE69119992 D1 DE 69119992D1
Authority
DE
Germany
Prior art keywords
steroids
inhibitors
amino
delta4
reductase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69119992T
Other languages
English (en)
Other versions
DE69119992T2 (de
Inventor
Philip M Weintraub
Joseph P Burkhart
Thomas R Blohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/671,555 external-priority patent/US5143909A/en
Priority claimed from US07/720,900 external-priority patent/US5120840A/en
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69119992D1 publication Critical patent/DE69119992D1/de
Application granted granted Critical
Publication of DE69119992T2 publication Critical patent/DE69119992T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69119992T 1990-08-01 1991-07-30 4-Amino-delta4-Steroide und ihre Verwendung als Inhibitoren von 5alpha-Reduktase Expired - Fee Related DE69119992T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56104190A 1990-08-01 1990-08-01
US07/671,555 US5143909A (en) 1991-03-19 1991-03-19 Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,900 US5120840A (en) 1990-08-01 1991-07-02 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Publications (2)

Publication Number Publication Date
DE69119992D1 true DE69119992D1 (de) 1996-07-11
DE69119992T2 DE69119992T2 (de) 1997-02-06

Family

ID=27415841

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69119992T Expired - Fee Related DE69119992T2 (de) 1990-08-01 1991-07-30 4-Amino-delta4-Steroide und ihre Verwendung als Inhibitoren von 5alpha-Reduktase

Country Status (17)

Country Link
EP (1) EP0469548B1 (de)
JP (1) JP3021819B2 (de)
KR (1) KR100186812B1 (de)
AT (1) ATE138931T1 (de)
AU (1) AU637247B2 (de)
CA (1) CA2048242C (de)
DE (1) DE69119992T2 (de)
DK (1) DK0469548T3 (de)
ES (1) ES2090184T3 (de)
FI (1) FI102377B (de)
GR (1) GR3020672T3 (de)
HU (1) HU210046B (de)
IE (1) IE75198B1 (de)
IL (1) IL98999A (de)
NO (1) NO180339C (de)
NZ (1) NZ239142A (de)
PT (1) PT98518B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5356935A (en) * 1993-12-13 1994-10-18 Eli Lilly And Company Reduced phenanthrenes
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CN102686600A (zh) 2009-02-05 2012-09-19 托凯药业股份有限公司 甾体cyp17抑制剂/抗雄激素物质的新型药物前体
EP2968370A4 (de) 2013-03-14 2016-09-21 Univ Maryland Mittel zur androgenrezeptor-abwärtsregelung und verwendungen davon
JP2016528252A (ja) 2013-08-12 2016-09-15 トーカイ ファーマシューティカルズ， インコーポレイテッド アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780070A (en) * 1972-09-21 1973-12-18 Schering Corp 4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives

Also Published As

Publication number Publication date
NO912981D0 (no) 1991-07-31
CA2048242A1 (en) 1992-02-02
IE75198B1 (en) 1997-08-27
HUT59156A (en) 1992-04-28
NO180339B (no) 1996-12-23
JP3021819B2 (ja) 2000-03-15
EP0469548A3 (en) 1992-06-03
KR100186812B1 (ko) 1999-04-01
FI913657A (fi) 1992-02-02
FI102377B1 (fi) 1998-11-30
ES2090184T3 (es) 1996-10-16
IL98999A (en) 1995-10-31
AU8136291A (en) 1992-02-06
NO180339C (no) 1997-04-02
EP0469548A2 (de) 1992-02-05
PT98518B (pt) 1999-01-29
FI913657A0 (fi) 1991-07-31
AU637247B2 (en) 1993-05-20
ATE138931T1 (de) 1996-06-15
GR3020672T3 (en) 1996-10-31
NO912981L (no) 1992-02-03
NZ239142A (en) 1994-05-26
JPH06172379A (ja) 1994-06-21
FI102377B (fi) 1998-11-30
DK0469548T3 (da) 1996-06-24
IL98999A0 (en) 1992-07-15
HU912558D0 (en) 1992-01-28
CA2048242C (en) 2003-04-15
IE912705A1 (en) 1992-02-12
PT98518A (pt) 1992-06-30
EP0469548B1 (de) 1996-06-05
HU210046B (en) 1995-01-30
DE69119992T2 (de) 1997-02-06
KR920004409A (ko) 1992-03-27

Similar Documents

Publication Publication Date Title
DE69119992T2 (de) 4-Amino-delta4-Steroide und ihre Verwendung als Inhibitoren von 5alpha-Reduktase
ATE260910T1 (de) 4-heteroaryl-tetrahydrochinoline und ihre verwendung als inhibitoren des cholesterin-ester- transfer-proteins (ctep)
DE3583189D1 (de) Carbazole und ihre verwendung als photoinitiatoren von photopolymerisierbaren, ungesaettigten verbindungen.
ATE177751T1 (de) Delta 16 ungesättigtes c17 heterocyclische steroide zur verwendung als steroid c17-20 lyase inhibitoren
DE69828964D1 (de) Aromatische maleimide und ihre verwendung als photoinitiatoren
ES2110213T3 (es) Derivado de n-acilglutamina.
IL105234A (en) Derivatives of 2-(acylalkenyl)- phenylacetic acid and their use as pesticides
ATE154607T1 (de) Neue steroide
ATE138073T1 (de) 4-amino-delta4,6-steroide und ihre verwendung als inhibitoren von 5alpha-reduktase
DE69215125T2 (de) Kardioaktive Steroide
DE69311123T2 (de) Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe
ATE85327T1 (de) Substituierte pyridylethanolamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren.
DE69020520D1 (de) 2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase.
GR900100394A (el) Νεοι μέ?οδοι λήψεως 6-με?υλ 19-ΝΟΡ στεροειδών και η μετατροπή αυτών εις 17α-υποκατεστημένα 19-ΝΟΡ πρεγναδιένια.
NO305556B1 (no) Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
ATE144779T1 (de) 17-phenyl-substituierte steroide mit cardiotonischer wirksamkeit
DE3763554D1 (de) Calixarenderivate und ihre verwendung als beschleuniger fuer schnellkleber.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee