DE69020520D1 - 2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase. - Google Patents

2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase.

Info

Publication number
DE69020520D1
DE69020520D1 DE69020520T DE69020520T DE69020520D1 DE 69020520 D1 DE69020520 D1 DE 69020520D1 DE 69020520 T DE69020520 T DE 69020520T DE 69020520 T DE69020520 T DE 69020520T DE 69020520 D1 DE69020520 D1 DE 69020520D1
Authority
DE
Germany
Prior art keywords
methyleneoxy
aromatase
hydroxylase
inhibitors
methylene bridged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69020520T
Other languages
English (en)
Other versions
DE69020520T2 (de
Inventor
Norton P Peet
J O'neil Johnston J O Johnston
Joseph P Burkhart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69020520D1 publication Critical patent/DE69020520D1/de
Publication of DE69020520T2 publication Critical patent/DE69020520T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69020520T 1989-12-20 1990-12-19 2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase. Expired - Fee Related DE69020520T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344189A 1989-12-20 1989-12-20

Publications (2)

Publication Number Publication Date
DE69020520D1 true DE69020520D1 (de) 1995-08-03
DE69020520T2 DE69020520T2 (de) 1995-11-30

Family

ID=23800602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69020520T Expired - Fee Related DE69020520T2 (de) 1989-12-20 1990-12-19 2,19-Methylenoxy- und 2,19-methylenthiogebrückte Steroide und ihre Verwendung als Inhibitoren von Aromatase und 19-Hydroxylase.

Country Status (20)

Country Link
EP (1) EP0434020B1 (de)
JP (1) JP2922653B2 (de)
KR (1) KR100187781B1 (de)
CN (1) CN1035768C (de)
AR (1) AR248410A1 (de)
AT (1) ATE124417T1 (de)
AU (1) AU630008B2 (de)
CA (1) CA2032311C (de)
DE (1) DE69020520T2 (de)
DK (1) DK0434020T3 (de)
ES (1) ES2076286T3 (de)
FI (1) FI107925B (de)
GR (1) GR3017136T3 (de)
HU (1) HU208024B (de)
IE (1) IE67557B1 (de)
IL (1) IL96695A (de)
NO (1) NO177676C (de)
NZ (1) NZ236473A (de)
PT (1) PT96258B (de)
ZA (1) ZA9010082B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491136A (en) * 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) * 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) * 1971-10-19 1976-05-04 Derek Harold Richard Barton Chemical compounds
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Also Published As

Publication number Publication date
CA2032311A1 (en) 1991-06-21
CN1035768C (zh) 1997-09-03
ES2076286T3 (es) 1995-11-01
AU6808390A (en) 1991-10-17
EP0434020A1 (de) 1991-06-26
FI107925B (fi) 2001-10-31
ZA9010082B (en) 1991-10-30
NO905494D0 (no) 1990-12-19
HU208024B (en) 1993-07-28
PT96258B (pt) 1998-09-30
JPH04128297A (ja) 1992-04-28
AR248410A1 (es) 1995-08-18
FI906269A (fi) 1991-06-21
PT96258A (pt) 1991-09-30
NO177676B (no) 1995-07-24
NZ236473A (en) 1993-04-28
NO905494L (no) 1991-06-21
HUT56380A (en) 1991-08-28
HU908299D0 (en) 1991-06-28
DE69020520T2 (de) 1995-11-30
CA2032311C (en) 2002-08-27
JP2922653B2 (ja) 1999-07-26
IE67557B1 (en) 1996-04-17
EP0434020B1 (de) 1995-06-28
IE904597A1 (en) 1991-07-03
DK0434020T3 (da) 1995-08-28
IL96695A0 (en) 1991-09-16
KR910011888A (ko) 1991-08-07
AU630008B2 (en) 1992-10-15
ATE124417T1 (de) 1995-07-15
FI906269A0 (fi) 1990-12-19
IL96695A (en) 1996-08-04
KR100187781B1 (ko) 1999-06-01
NO177676C (no) 1995-11-01
CN1052678A (zh) 1991-07-03
GR3017136T3 (en) 1995-11-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee