DK0434020T3 - 2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase - Google Patents

2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase

Info

Publication number
DK0434020T3
DK0434020T3 DK90124739.5T DK90124739T DK0434020T3 DK 0434020 T3 DK0434020 T3 DK 0434020T3 DK 90124739 T DK90124739 T DK 90124739T DK 0434020 T3 DK0434020 T3 DK 0434020T3
Authority
DK
Denmark
Prior art keywords
methylthiobro
methyleneoxy
aromatase
hydroxylase
inhibitors
Prior art date
Application number
DK90124739.5T
Other languages
English (en)
Inventor
Norton P Peet
J Oneil Johnston
Joseph P Burkhart
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of DK0434020T3 publication Critical patent/DK0434020T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK90124739.5T 1989-12-20 1990-12-19 2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase DK0434020T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344189A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
DK0434020T3 true DK0434020T3 (da) 1995-08-28

Family

ID=23800602

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90124739.5T DK0434020T3 (da) 1989-12-20 1990-12-19 2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase

Country Status (20)

Country Link
EP (1) EP0434020B1 (da)
JP (1) JP2922653B2 (da)
KR (1) KR100187781B1 (da)
CN (1) CN1035768C (da)
AR (1) AR248410A1 (da)
AT (1) ATE124417T1 (da)
AU (1) AU630008B2 (da)
CA (1) CA2032311C (da)
DE (1) DE69020520T2 (da)
DK (1) DK0434020T3 (da)
ES (1) ES2076286T3 (da)
FI (1) FI107925B (da)
GR (1) GR3017136T3 (da)
HU (1) HU208024B (da)
IE (1) IE67557B1 (da)
IL (1) IL96695A (da)
NO (1) NO177676C (da)
NZ (1) NZ236473A (da)
PT (1) PT96258B (da)
ZA (1) ZA9010082B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491136A (en) * 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) * 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) * 1971-10-19 1976-05-04 Derek Harold Richard Barton Chemical compounds
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Also Published As

Publication number Publication date
CA2032311A1 (en) 1991-06-21
CN1035768C (zh) 1997-09-03
ES2076286T3 (es) 1995-11-01
AU6808390A (en) 1991-10-17
EP0434020A1 (en) 1991-06-26
FI107925B (fi) 2001-10-31
ZA9010082B (en) 1991-10-30
NO905494D0 (no) 1990-12-19
HU208024B (en) 1993-07-28
PT96258B (pt) 1998-09-30
JPH04128297A (ja) 1992-04-28
AR248410A1 (es) 1995-08-18
FI906269A (fi) 1991-06-21
PT96258A (pt) 1991-09-30
NO177676B (no) 1995-07-24
NZ236473A (en) 1993-04-28
NO905494L (no) 1991-06-21
HUT56380A (en) 1991-08-28
HU908299D0 (en) 1991-06-28
DE69020520T2 (de) 1995-11-30
CA2032311C (en) 2002-08-27
JP2922653B2 (ja) 1999-07-26
DE69020520D1 (de) 1995-08-03
IE67557B1 (en) 1996-04-17
EP0434020B1 (en) 1995-06-28
IE904597A1 (en) 1991-07-03
IL96695A0 (en) 1991-09-16
KR910011888A (ko) 1991-08-07
AU630008B2 (en) 1992-10-15
ATE124417T1 (de) 1995-07-15
FI906269A0 (fi) 1990-12-19
IL96695A (en) 1996-08-04
KR100187781B1 (ko) 1999-06-01
NO177676C (no) 1995-11-01
CN1052678A (zh) 1991-07-03
GR3017136T3 (en) 1995-11-30

Similar Documents

Publication Publication Date Title
NO941929L (no) Tokotrienoler og tokotrienol-lignende sammensetninger og fremgangsmåter for deres anvendelse
DK543189A (da) Lysyloxidaseinhibitorer og deres anvendelse
NO941679D0 (no) Gallesyrederivater, fremgangsmåte for fremstilling og deres anvendelse
DK288785A (da) Benzensulfonamido-derivater til terapeutisk anvendelse og fremgangsmaade til fremstilling af saadanne derivater
NO984761D0 (no) Aminoisokinoliner og aminotienopyridinderivater og deres anvendelse som antiinflammatoriske midler
DK347986A (da) N-substituerede arylalkyl- og -arylalkylenaminoheterocycliske forbindelser og deres anvendelse som cardiovaskulaere, antihistamin- og antisekretoriske midler
DK368687A (da) Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
DK582787A (da) Dihydropyridin-forbindelser og deres anvendelse som antiallergiske og antiinflammatoriske midler
DK15080A (da) Urinstofderivater deres fremstilling og anvendelse som pesticider
DK651087D0 (da) Renininhibitorer iii, deres fremstilling og anvendelse
DK475388D0 (da) Benzazepin-derivater og deres anvendelse som cardiovasculaere midler
NO960029L (no) Nye (1-fenyl-1-heterocyklyl)alkanderivater og deres anvendelse som neurobeskyttelsesmidler
DK408385A (da) Sulfonamider og deres anvendelse som herbicider
NO972256D0 (no) O-Benzyloksimeterderivater og deres anvendelse som pesticider
DK360189A (da) S-adenosyl-methionin-decarboxylase-inhibitorer, deres fremstilling og anvendelse
DK116087D0 (da) 2-oeheterocyclylmethylsulfinylaathienoimidazol-forbindelser og deres anvendelse som antiulcusmidler
DK0434020T3 (da) 2,19-Methylenoxy- og 2,19-methylenthiobroforbundne steroider og deres anvendelse som inhibitorer af aromatase og 19-hydroxylase
DK437287D0 (da) 2,3-dihydrofuranderivater, deres fremstilling og deres anvendelse som mellemprodukter til fremstilling af tetrahydrofuranderivater
DK164785C (da) 5-aryl-2,4-dialkyl-3h-1,2,4-triazol-3-thioner, deres fremstilling og deres anvendelse til fremstilling af antipedressive midler
DK2489D0 (da) Anvendelse af benzimidazolderivater, benzimidazolderivater og fremstillingen heraf samt ved fremgangsmaaden anvendelige mellemprodukter og fremstillingen heraf
DK383587D0 (da) Hydroximinsyrer af 7-oxabicycloheptan-substituerede ethre og thioethre samt deres anvendelse som antiallergiske midler
DK0675681T3 (da) Arylamino-alkoiminoderivater og deres anvendelse som fungicider
NO952483D0 (no) Seskviterpener, deres fremstilling og anvendelse som inhibitorer innvirkende på gababenzodiazepinreseptorer
DK395684D0 (da) Fluorerede pyrrolidonderivater og deres anvendelse som herbicider
DK120989A (da) 1-carbonylderivater af 4-aryl-4-aryloxypiperidiner, deres fremstilling og anvendelse