NO177676C - Analogifremgangsmåte for fremstilling av terapeutisk aktive steroider med 2,19-methylenoxy- eller 2,19-methylenthio-bro - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive steroider med 2,19-methylenoxy- eller 2,19-methylenthio-bro

Info

Publication number
NO177676C
NO177676C NO905494A NO905494A NO177676C NO 177676 C NO177676 C NO 177676C NO 905494 A NO905494 A NO 905494A NO 905494 A NO905494 A NO 905494A NO 177676 C NO177676 C NO 177676C
Authority
NO
Norway
Prior art keywords
methyleneoxy
methylthio
bridge
preparation
therapeutically active
Prior art date
Application number
NO905494A
Other languages
English (en)
Other versions
NO905494D0 (no
NO905494L (no
NO177676B (no
Inventor
Norton Paul Peet
John O'neal Johnston
Joseph Paul Burkhart
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO905494D0 publication Critical patent/NO905494D0/no
Publication of NO905494L publication Critical patent/NO905494L/no
Publication of NO177676B publication Critical patent/NO177676B/no
Publication of NO177676C publication Critical patent/NO177676C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO905494A 1989-12-20 1990-12-19 Analogifremgangsmåte for fremstilling av terapeutisk aktive steroider med 2,19-methylenoxy- eller 2,19-methylenthio-bro NO177676C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344189A 1989-12-20 1989-12-20

Publications (4)

Publication Number Publication Date
NO905494D0 NO905494D0 (no) 1990-12-19
NO905494L NO905494L (no) 1991-06-21
NO177676B NO177676B (no) 1995-07-24
NO177676C true NO177676C (no) 1995-11-01

Family

ID=23800602

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905494A NO177676C (no) 1989-12-20 1990-12-19 Analogifremgangsmåte for fremstilling av terapeutisk aktive steroider med 2,19-methylenoxy- eller 2,19-methylenthio-bro

Country Status (20)

Country Link
EP (1) EP0434020B1 (no)
JP (1) JP2922653B2 (no)
KR (1) KR100187781B1 (no)
CN (1) CN1035768C (no)
AR (1) AR248410A1 (no)
AT (1) ATE124417T1 (no)
AU (1) AU630008B2 (no)
CA (1) CA2032311C (no)
DE (1) DE69020520T2 (no)
DK (1) DK0434020T3 (no)
ES (1) ES2076286T3 (no)
FI (1) FI107925B (no)
GR (1) GR3017136T3 (no)
HU (1) HU208024B (no)
IE (1) IE67557B1 (no)
IL (1) IL96695A (no)
NO (1) NO177676C (no)
NZ (1) NZ236473A (no)
PT (1) PT96258B (no)
ZA (1) ZA9010082B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491136A (en) * 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) * 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) * 1971-10-19 1976-05-04 Derek Harold Richard Barton Chemical compounds
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Also Published As

Publication number Publication date
HU908299D0 (en) 1991-06-28
JP2922653B2 (ja) 1999-07-26
EP0434020B1 (en) 1995-06-28
GR3017136T3 (en) 1995-11-30
KR910011888A (ko) 1991-08-07
NZ236473A (en) 1993-04-28
IE67557B1 (en) 1996-04-17
AU630008B2 (en) 1992-10-15
FI906269A0 (fi) 1990-12-19
CN1052678A (zh) 1991-07-03
NO905494D0 (no) 1990-12-19
IE904597A1 (en) 1991-07-03
ZA9010082B (en) 1991-10-30
ATE124417T1 (de) 1995-07-15
CA2032311C (en) 2002-08-27
ES2076286T3 (es) 1995-11-01
DK0434020T3 (da) 1995-08-28
IL96695A0 (en) 1991-09-16
PT96258B (pt) 1998-09-30
AR248410A1 (es) 1995-08-18
NO905494L (no) 1991-06-21
HUT56380A (en) 1991-08-28
DE69020520T2 (de) 1995-11-30
IL96695A (en) 1996-08-04
NO177676B (no) 1995-07-24
CN1035768C (zh) 1997-09-03
CA2032311A1 (en) 1991-06-21
DE69020520D1 (de) 1995-08-03
JPH04128297A (ja) 1992-04-28
PT96258A (pt) 1991-09-30
FI906269A (fi) 1991-06-21
FI107925B (fi) 2001-10-31
KR100187781B1 (ko) 1999-06-01
AU6808390A (en) 1991-10-17
HU208024B (en) 1993-07-28
EP0434020A1 (en) 1991-06-26

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Free format text: LAPSED IN JUNE 2001