NO174892C - Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelser - Google Patents
Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelserInfo
- Publication number
- NO174892C NO174892C NO902084A NO902084A NO174892C NO 174892 C NO174892 C NO 174892C NO 902084 A NO902084 A NO 902084A NO 902084 A NO902084 A NO 902084A NO 174892 C NO174892 C NO 174892C
- Authority
- NO
- Norway
- Prior art keywords
- dihydropyrrolizine
- substituted
- compounds
- preparation
- therapeutically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3915450A DE3915450A1 (de) | 1989-05-11 | 1989-05-11 | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO902084D0 NO902084D0 (no) | 1990-05-10 |
| NO902084L NO902084L (no) | 1990-11-12 |
| NO174892B NO174892B (no) | 1994-04-18 |
| NO174892C true NO174892C (no) | 1994-07-27 |
Family
ID=6380477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902084A NO174892C (no) | 1989-05-11 | 1990-05-10 | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelser |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0397175B1 (no) |
| JP (1) | JP2796876B2 (no) |
| KR (1) | KR0173455B1 (no) |
| AR (1) | AR246256A1 (no) |
| AT (1) | ATE98246T1 (no) |
| AU (1) | AU637098B2 (no) |
| CA (1) | CA2016501C (no) |
| DD (1) | DD294260A5 (no) |
| DE (2) | DE3915450A1 (no) |
| DK (1) | DK0397175T3 (no) |
| ES (1) | ES2062160T3 (no) |
| FI (1) | FI95258C (no) |
| NO (1) | NO174892C (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE9422447U1 (de) * | 1993-01-15 | 2002-10-17 | G D Searle Llc Chicago | 3,4-Diarylthiophene und Analoga davon, sowie deren Verwendung als entzündungshemmende Mittel |
| US6492413B2 (en) | 1993-01-15 | 2002-12-10 | G.D. Searle & Co. | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| DE4338770A1 (de) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| DE4419247A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
| DE4419315A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| DE4419246A1 (de) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie |
| WO1998005637A1 (de) * | 1996-08-01 | 1998-02-12 | Merckle Gmbh | Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a¿2? |
| RS50374B (sr) * | 2000-01-28 | 2009-11-10 | Merckle Gmbh., | Postupak za dobijanje 6-(4-hlorfenil)-2,2-dimetil-7-fenil -2,3-dihidro-1h-pirolizin-5-il-sirćetne kiseline |
| DE10004157A1 (de) * | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie |
| KR20020007836A (ko) * | 2000-07-19 | 2002-01-29 | 신덕호 | 골프공 |
| DE10141285A1 (de) | 2001-08-23 | 2003-03-27 | Merckle Gmbh | Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
| DE102005012971A1 (de) * | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1156480A (en) * | 1965-04-30 | 1969-06-25 | Firmenich & Cie | Furan Flavouring Agents |
| AU429651B2 (en) * | 1968-08-08 | 1972-11-01 | Commonwealth Scientific And Industrial Research Organization | Antiviral 6, 7 dihydro 5h pyrrolizines and related compounds |
| DE2062984A1 (en) * | 1970-12-21 | 1972-06-22 | Messerschmitt, Thilo, 8094 Reitmehring; Dobeneck, Henning von, 8021 Icking | 2-unsubstd-5-formyl-pyrrole prepn - by catalytic hydrogenation of 2-halo-5-formyl-pyrroles |
| DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
| JPS5217074B2 (no) * | 1972-04-25 | 1977-05-13 | ||
| JPS6011899B2 (ja) * | 1978-12-27 | 1985-03-28 | 財団法人相模中央化学研究所 | ピロ−ル酢酸誘導体の製造方法 |
| JPS5687558A (en) * | 1979-11-27 | 1981-07-16 | Mcneilab Inc | Manufacture of pyrrolee22acetic acids |
| US4284562A (en) * | 1979-11-27 | 1981-08-18 | Mcneilab, Inc. | Process for preparing pyrrole-2-acetic acids |
| JPS56100784A (en) * | 1980-01-16 | 1981-08-12 | Yoshitomi Pharmaceut Ind Ltd | Indolizine derivative |
| US4327221A (en) * | 1980-10-15 | 1982-04-27 | American Home Products Corporation | 2-Substituted-3-hydroxythiazolo(2,3-8)-thiazolium salts and mesoionic didehydro derivatives thereof |
| JPS57501964A (no) * | 1980-12-15 | 1982-11-04 | ||
| DE3368416D1 (en) * | 1982-02-25 | 1987-01-29 | Beecham Group Plc | Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them |
| FR2539417A1 (fr) * | 1983-01-13 | 1984-07-20 | Rhone Poulenc Sante | Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent |
| FR2557111B1 (fr) * | 1983-12-21 | 1986-04-11 | Rhone Poulenc Sante | Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent |
| IL78834A (en) * | 1985-05-23 | 1992-07-15 | Smithkline Beckman Corp | 2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines |
| FR2601016B1 (fr) * | 1986-07-04 | 1988-10-07 | Rhone Poulenc Sante | Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2617484B1 (fr) * | 1987-07-02 | 1989-10-20 | Rhone Poulenc Sante | Procede de preparation de l'acide (pyridyl-3)-3 1h-3h-pyrrolo (1,2-c) thiazolecarboxylique-7 dextrogyre |
-
1989
- 1989-05-11 DE DE3915450A patent/DE3915450A1/de not_active Withdrawn
-
1990
- 1990-05-07 AU AU54800/90A patent/AU637098B2/en not_active Ceased
- 1990-05-09 FI FI902316A patent/FI95258C/fi active IP Right Grant
- 1990-05-09 DD DD90340498A patent/DD294260A5/de unknown
- 1990-05-10 DE DE90108827T patent/DE59003753D1/de not_active Expired - Fee Related
- 1990-05-10 AT AT90108827T patent/ATE98246T1/de not_active IP Right Cessation
- 1990-05-10 NO NO902084A patent/NO174892C/no not_active IP Right Cessation
- 1990-05-10 EP EP90108827A patent/EP0397175B1/de not_active Expired - Lifetime
- 1990-05-10 ES ES90108827T patent/ES2062160T3/es not_active Expired - Lifetime
- 1990-05-10 DK DK90108827.8T patent/DK0397175T3/da active
- 1990-05-10 CA CA002016501A patent/CA2016501C/en not_active Expired - Lifetime
- 1990-05-11 AR AR90316838A patent/AR246256A1/es active
- 1990-05-11 KR KR1019900006713A patent/KR0173455B1/ko not_active IP Right Cessation
- 1990-05-11 JP JP2122816A patent/JP2796876B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0397175T3 (da) | 1994-02-14 |
| NO902084D0 (no) | 1990-05-10 |
| NO174892B (no) | 1994-04-18 |
| CA2016501C (en) | 2001-10-09 |
| EP0397175B1 (de) | 1993-12-08 |
| FI95258B (fi) | 1995-09-29 |
| ES2062160T3 (es) | 1994-12-16 |
| ATE98246T1 (de) | 1993-12-15 |
| FI902316A0 (fi) | 1990-05-09 |
| NO902084L (no) | 1990-11-12 |
| DD294260A5 (de) | 1991-09-26 |
| AU5480090A (en) | 1990-11-15 |
| JP2796876B2 (ja) | 1998-09-10 |
| KR900018103A (ko) | 1990-12-20 |
| DE3915450A1 (de) | 1990-11-15 |
| JPH035455A (ja) | 1991-01-11 |
| KR0173455B1 (ko) | 1999-02-01 |
| AR246256A1 (es) | 1994-07-29 |
| EP0397175A1 (de) | 1990-11-14 |
| FI95258C (fi) | 1996-01-10 |
| DE59003753D1 (de) | 1994-01-20 |
| AU637098B2 (en) | 1993-05-20 |
| CA2016501A1 (en) | 1990-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |