CA2016501A1 - Substituted pyrrole compounds and their applications in pharmacy - Google Patents
Substituted pyrrole compounds and their applications in pharmacyInfo
- Publication number
- CA2016501A1 CA2016501A1 CA002016501A CA2016501A CA2016501A1 CA 2016501 A1 CA2016501 A1 CA 2016501A1 CA 002016501 A CA002016501 A CA 002016501A CA 2016501 A CA2016501 A CA 2016501A CA 2016501 A1 CA2016501 A1 CA 2016501A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- alkyl
- denotes
- compounds
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003233 pyrroles Chemical class 0.000 title abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 nitro- Chemical class 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 102000003820 Lipoxygenases Human genes 0.000 abstract 1
- 108090000128 Lipoxygenases Proteins 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000000552 rheumatic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
The invention concerns substituted pyrrole compounds and their applications in pharmacy. The compounds of the invention are potent inhibitors of lipoxygenase and cyclo-oxygenase and therefore are suitable to treat the set of rheumatic illnesses and to prevent allergically induced ailments.
The compounds have the general formula:
The compounds have the general formula:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3915450A DE3915450A1 (en) | 1989-05-11 | 1989-05-11 | SUBSTITUTED PYRROL COMPOUNDS AND THEIR USE IN PHARMACY |
DEP3915450.5 | 1989-05-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2016501A1 true CA2016501A1 (en) | 1990-11-11 |
CA2016501C CA2016501C (en) | 2001-10-09 |
Family
ID=6380477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002016501A Expired - Lifetime CA2016501C (en) | 1989-05-11 | 1990-05-10 | Substituted pyrrole compounds and their applications in pharmacy |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0397175B1 (en) |
JP (1) | JP2796876B2 (en) |
KR (1) | KR0173455B1 (en) |
AR (1) | AR246256A1 (en) |
AT (1) | ATE98246T1 (en) |
AU (1) | AU637098B2 (en) |
CA (1) | CA2016501C (en) |
DD (1) | DD294260A5 (en) |
DE (2) | DE3915450A1 (en) |
DK (1) | DK0397175T3 (en) |
ES (1) | ES2062160T3 (en) |
FI (1) | FI95258C (en) |
NO (1) | NO174892C (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0679157T3 (en) * | 1993-01-15 | 1998-07-27 | Searle & Co | Novel 3,4-diarylthiophenes and analogs thereof for use as anti-inflammatory agents |
US6492413B2 (en) | 1993-01-15 | 2002-12-10 | G.D. Searle & Co. | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
DE4338770A1 (en) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶ |
DE4419247A1 (en) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | New pyrrolizine keto-acid, keto-ester and carboxamide derivs. |
DE4419246A1 (en) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | New hetero-aryl substd. pyrrolizine derivs. |
DE4419315A1 (en) * | 1994-06-01 | 1995-12-07 | Merckle Gmbh | New hetero- and oxo-pyrrolizine derivs. |
KR100482268B1 (en) * | 1996-08-01 | 2005-04-14 | 메르클레 게엠베하 | Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a2 |
EP1252164B1 (en) * | 2000-01-28 | 2004-03-24 | Merckle Gmbh | Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid |
DE10004157A1 (en) * | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | New pyridyl- or pyrimidinyl-substituted bicyclic pyrrole derivatives, are cyclokine release inhibitors useful for treating immune system-related disorders, e.g. cancer, multiple sclerosis or arthritis |
KR20020007836A (en) * | 2000-07-19 | 2002-01-29 | 신덕호 | Golf ball |
DE10141285A1 (en) | 2001-08-23 | 2003-03-27 | Merckle Gmbh | Process for the preparation of 6- (4-chlorophenyl) -2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid |
DE102005012971A1 (en) | 2005-03-21 | 2006-09-28 | Merckle Gmbh | Polymorphic form of 6- (4-chlorophenyl) -2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl-acetic acid |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1156473A (en) * | 1965-04-30 | 1969-06-25 | Firmenich & Cie | Thiazole Alcohols |
AU429651B2 (en) * | 1968-08-08 | 1972-11-01 | Commonwealth Scientific And Industrial Research Organization | Antiviral 6, 7 dihydro 5h pyrrolizines and related compounds |
DE2062984A1 (en) * | 1970-12-21 | 1972-06-22 | Messerschmitt, Thilo, 8094 Reitmehring; Dobeneck, Henning von, 8021 Icking | 2-unsubstd-5-formyl-pyrrole prepn - by catalytic hydrogenation of 2-halo-5-formyl-pyrroles |
DE2261965A1 (en) * | 1971-12-23 | 1973-06-28 | Continental Pharma | DERIVATIVES OF PYRROE ACETIC ACID AND ITS SALTS AND OF PYRROL ACETONITRILE, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS, PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS AND USES OF THESE COMPOUNDS AND PRODUCTS |
JPS5217074B2 (en) * | 1972-04-25 | 1977-05-13 | ||
JPS6011899B2 (en) * | 1978-12-27 | 1985-03-28 | 財団法人相模中央化学研究所 | Method for producing pyrrole acetic acid derivative |
JPS5687558A (en) * | 1979-11-27 | 1981-07-16 | Mcneilab Inc | Manufacture of pyrrolee22acetic acids |
US4284562A (en) * | 1979-11-27 | 1981-08-18 | Mcneilab, Inc. | Process for preparing pyrrole-2-acetic acids |
JPS56100784A (en) * | 1980-01-16 | 1981-08-12 | Yoshitomi Pharmaceut Ind Ltd | Indolizine derivative |
US4327221A (en) * | 1980-10-15 | 1982-04-27 | American Home Products Corporation | 2-Substituted-3-hydroxythiazolo(2,3-8)-thiazolium salts and mesoionic didehydro derivatives thereof |
WO1982002044A1 (en) * | 1980-12-15 | 1982-06-24 | Corp Ethyl | Preparation of pyrrole esters |
EP0091181B1 (en) * | 1982-02-25 | 1986-12-17 | Beecham Group Plc | Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them |
FR2539417A1 (en) * | 1983-01-13 | 1984-07-20 | Rhone Poulenc Sante | NEW PYRROLO-1, 2 HETEROCYCLES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
FR2557111B1 (en) * | 1983-12-21 | 1986-04-11 | Rhone Poulenc Sante | NOVEL ORTHO-CONDENSES OF PYRROLE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
IL78834A (en) * | 1985-05-23 | 1992-07-15 | Smithkline Beckman Corp | 2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines |
FR2601016B1 (en) * | 1986-07-04 | 1988-10-07 | Rhone Poulenc Sante | NOVEL 1H, 3H-PYRROLO (1,2-C) THIAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2617484B1 (en) * | 1987-07-02 | 1989-10-20 | Rhone Poulenc Sante | PROCESS FOR THE PREPARATION OF ACID (PYRIDYL-3) -3 1H-3H-PYRROLO (1,2-C) THIAZOLECARBOXYLIQUE-7 DEXTROGYRE |
-
1989
- 1989-05-11 DE DE3915450A patent/DE3915450A1/en not_active Withdrawn
-
1990
- 1990-05-07 AU AU54800/90A patent/AU637098B2/en not_active Ceased
- 1990-05-09 FI FI902316A patent/FI95258C/en active IP Right Grant
- 1990-05-09 DD DD90340498A patent/DD294260A5/en unknown
- 1990-05-10 EP EP90108827A patent/EP0397175B1/en not_active Expired - Lifetime
- 1990-05-10 CA CA002016501A patent/CA2016501C/en not_active Expired - Lifetime
- 1990-05-10 ES ES90108827T patent/ES2062160T3/en not_active Expired - Lifetime
- 1990-05-10 DE DE90108827T patent/DE59003753D1/en not_active Expired - Fee Related
- 1990-05-10 AT AT90108827T patent/ATE98246T1/en not_active IP Right Cessation
- 1990-05-10 DK DK90108827.8T patent/DK0397175T3/en active
- 1990-05-10 NO NO902084A patent/NO174892C/en not_active IP Right Cessation
- 1990-05-11 KR KR1019900006713A patent/KR0173455B1/en not_active IP Right Cessation
- 1990-05-11 AR AR90316838A patent/AR246256A1/en active
- 1990-05-11 JP JP2122816A patent/JP2796876B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE3915450A1 (en) | 1990-11-15 |
FI95258B (en) | 1995-09-29 |
DD294260A5 (en) | 1991-09-26 |
EP0397175A1 (en) | 1990-11-14 |
FI95258C (en) | 1996-01-10 |
NO902084L (en) | 1990-11-12 |
EP0397175B1 (en) | 1993-12-08 |
ES2062160T3 (en) | 1994-12-16 |
DE59003753D1 (en) | 1994-01-20 |
NO174892B (en) | 1994-04-18 |
DK0397175T3 (en) | 1994-02-14 |
FI902316A0 (en) | 1990-05-09 |
KR0173455B1 (en) | 1999-02-01 |
NO902084D0 (en) | 1990-05-10 |
ATE98246T1 (en) | 1993-12-15 |
NO174892C (en) | 1994-07-27 |
JPH035455A (en) | 1991-01-11 |
CA2016501C (en) | 2001-10-09 |
JP2796876B2 (en) | 1998-09-10 |
AR246256A1 (en) | 1994-07-29 |
KR900018103A (en) | 1990-12-20 |
AU5480090A (en) | 1990-11-15 |
AU637098B2 (en) | 1993-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |