FI902316A0 - Process for the preparation of therapeutically-substituted dihydropyrrolizine compounds - Google Patents

Process for the preparation of therapeutically-substituted dihydropyrrolizine compounds

Info

Publication number
FI902316A0
FI902316A0 FI902316A FI902316A FI902316A0 FI 902316 A0 FI902316 A0 FI 902316A0 FI 902316 A FI902316 A FI 902316A FI 902316 A FI902316 A FI 902316A FI 902316 A0 FI902316 A0 FI 902316A0
Authority
FI
Finland
Prior art keywords
dihydropyrrolizine
therapeutically
substituted
compounds
preparation
Prior art date
Application number
FI902316A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI95258C (en
FI95258B (en
Inventor
Gerd Dannhardt
Ludwig Steindl
Matthias Lehr
Original Assignee
Danhardt Gerd
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danhardt Gerd, Merckle Gmbh filed Critical Danhardt Gerd
Publication of FI902316A0 publication Critical patent/FI902316A0/en
Application granted granted Critical
Publication of FI95258B publication Critical patent/FI95258B/en
Publication of FI95258C publication Critical patent/FI95258C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI902316A 1989-05-11 1990-05-09 The method prepares therapeutically active substituted dihydropyrrolizine compounds FI95258C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3915450 1989-05-11
DE3915450A DE3915450A1 (en) 1989-05-11 1989-05-11 SUBSTITUTED PYRROL COMPOUNDS AND THEIR USE IN PHARMACY

Publications (3)

Publication Number Publication Date
FI902316A0 true FI902316A0 (en) 1990-05-09
FI95258B FI95258B (en) 1995-09-29
FI95258C FI95258C (en) 1996-01-10

Family

ID=6380477

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902316A FI95258C (en) 1989-05-11 1990-05-09 The method prepares therapeutically active substituted dihydropyrrolizine compounds

Country Status (13)

Country Link
EP (1) EP0397175B1 (en)
JP (1) JP2796876B2 (en)
KR (1) KR0173455B1 (en)
AR (1) AR246256A1 (en)
AT (1) ATE98246T1 (en)
AU (1) AU637098B2 (en)
CA (1) CA2016501C (en)
DD (1) DD294260A5 (en)
DE (2) DE3915450A1 (en)
DK (1) DK0397175T3 (en)
ES (1) ES2062160T3 (en)
FI (1) FI95258C (en)
NO (1) NO174892C (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6492413B2 (en) 1993-01-15 2002-12-10 G.D. Searle & Co. 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
AU6027694A (en) * 1993-01-15 1994-08-15 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DE4338770A1 (en) * 1993-11-12 1995-05-18 Matthias Dr Lehr Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶
DE4419246A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New hetero-aryl substd. pyrrolizine derivs.
DE4419247A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New pyrrolizine keto-acid, keto-ester and carboxamide derivs.
DE4419315A1 (en) * 1994-06-01 1995-12-07 Merckle Gmbh New hetero- and oxo-pyrrolizine derivs.
AU3767997A (en) * 1996-08-01 1998-02-25 Merckle Gmbh Acylpyrroldicarboxylic acids and acylindoldicarboxylic acids and their derivatives and inhibitors of the cytosolic phospholipase a2
EA004938B1 (en) * 2000-01-28 2004-10-28 Меркле Гмбх Method for producing 6-(4-chlorophyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid
DE10004157A1 (en) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik New pyridyl- or pyrimidinyl-substituted bicyclic pyrrole derivatives, are cyclokine release inhibitors useful for treating immune system-related disorders, e.g. cancer, multiple sclerosis or arthritis
KR20020007836A (en) * 2000-07-19 2002-01-29 신덕호 Golf ball
DE10141285A1 (en) 2001-08-23 2003-03-27 Merckle Gmbh Process for the preparation of 6- (4-chlorophenyl) -2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid
DE102005012971A1 (en) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphic form of 6- (4-chlorophenyl) -2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl-acetic acid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1156486A (en) * 1965-04-30 1969-06-25 Firmenich & Cie Ketonic Flavouring Agents
AU429651B2 (en) * 1968-08-08 1972-11-01 Commonwealth Scientific And Industrial Research Organization Antiviral 6, 7 dihydro 5h pyrrolizines and related compounds
DE2062984A1 (en) * 1970-12-21 1972-06-22 Messerschmitt, Thilo, 8094 Reitmehring; Dobeneck, Henning von, 8021 Icking 2-unsubstd-5-formyl-pyrrole prepn - by catalytic hydrogenation of 2-halo-5-formyl-pyrroles
DE2261965A1 (en) * 1971-12-23 1973-06-28 Continental Pharma DERIVATIVES OF PYRROE ACETIC ACID AND ITS SALTS AND OF PYRROL ACETONITRILE, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS, PHARMACEUTICAL PRODUCTS CONTAINING THESE COMPOUNDS AND USES OF THESE COMPOUNDS AND PRODUCTS
JPS5217074B2 (en) * 1972-04-25 1977-05-13
JPS6011899B2 (en) * 1978-12-27 1985-03-28 財団法人相模中央化学研究所 Method for producing pyrrole acetic acid derivative
JPS5687558A (en) * 1979-11-27 1981-07-16 Mcneilab Inc Manufacture of pyrrolee22acetic acids
US4284562A (en) * 1979-11-27 1981-08-18 Mcneilab, Inc. Process for preparing pyrrole-2-acetic acids
JPS56100784A (en) * 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
US4327221A (en) * 1980-10-15 1982-04-27 American Home Products Corporation 2-Substituted-3-hydroxythiazolo(2,3-8)-thiazolium salts and mesoionic didehydro derivatives thereof
WO1982002044A1 (en) * 1980-12-15 1982-06-24 Corp Ethyl Preparation of pyrrole esters
DE3368416D1 (en) * 1982-02-25 1987-01-29 Beecham Group Plc Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them
FR2539417A1 (en) * 1983-01-13 1984-07-20 Rhone Poulenc Sante NEW PYRROLO-1, 2 HETEROCYCLES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
FR2557111B1 (en) * 1983-12-21 1986-04-11 Rhone Poulenc Sante NOVEL ORTHO-CONDENSES OF PYRROLE, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
IL78834A (en) * 1985-05-23 1992-07-15 Smithkline Beckman Corp 2,3-dihydro-5-(1,4-dihydropyridin-4-yl)-6-phenylimidazo(2,1-b)thiazoles and 6,7-dihydro-3-(1,4-dihydropyridin-4-yl)-2-phenyl-5h-imidazo(2,1-b)(1,3)thiazines and their use as intermediates in a process for preparing the corresponding pyridyl-substituted imidazo(2,1-b)thiazoles and 5h-imidazo(2,1-b)(1,3)thiazines
FR2601016B1 (en) * 1986-07-04 1988-10-07 Rhone Poulenc Sante NOVEL 1H, 3H-PYRROLO (1,2-C) THIAZOLE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2617484B1 (en) * 1987-07-02 1989-10-20 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF ACID (PYRIDYL-3) -3 1H-3H-PYRROLO (1,2-C) THIAZOLECARBOXYLIQUE-7 DEXTROGYRE

Also Published As

Publication number Publication date
EP0397175A1 (en) 1990-11-14
KR0173455B1 (en) 1999-02-01
NO902084D0 (en) 1990-05-10
DD294260A5 (en) 1991-09-26
NO174892B (en) 1994-04-18
CA2016501A1 (en) 1990-11-11
FI95258C (en) 1996-01-10
JP2796876B2 (en) 1998-09-10
JPH035455A (en) 1991-01-11
DK0397175T3 (en) 1994-02-14
ES2062160T3 (en) 1994-12-16
NO174892C (en) 1994-07-27
EP0397175B1 (en) 1993-12-08
DE59003753D1 (en) 1994-01-20
AR246256A1 (en) 1994-07-29
FI95258B (en) 1995-09-29
AU637098B2 (en) 1993-05-20
NO902084L (en) 1990-11-12
ATE98246T1 (en) 1993-12-15
AU5480090A (en) 1990-11-15
CA2016501C (en) 2001-10-09
DE3915450A1 (en) 1990-11-15
KR900018103A (en) 1990-12-20

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Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: DANNHARDT, GERD

Owner name: MERCKLE GMBH