NO177096C - Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner - Google Patents
Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinolinerInfo
- Publication number
- NO177096C NO177096C NO904059A NO904059A NO177096C NO 177096 C NO177096 C NO 177096C NO 904059 A NO904059 A NO 904059A NO 904059 A NO904059 A NO 904059A NO 177096 C NO177096 C NO 177096C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- therapeutically active
- analogous process
- substituted isoquinolines
- isoquinolines
- Prior art date
Links
- 150000002537 isoquinolines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/409,521 US4956371A (en) | 1989-09-19 | 1989-09-19 | Substituted isoquinolines and methods of using same |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO904059D0 NO904059D0 (no) | 1990-09-18 |
| NO904059L NO904059L (no) | 1991-03-20 |
| NO177096B NO177096B (no) | 1995-04-10 |
| NO177096C true NO177096C (no) | 1995-07-26 |
Family
ID=23620860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO904059A NO177096C (no) | 1989-09-19 | 1990-09-18 | Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4956371A (no) |
| EP (1) | EP0422328A3 (no) |
| JP (1) | JPH03145469A (no) |
| KR (1) | KR940000162B1 (no) |
| CN (1) | CN1050381A (no) |
| AR (1) | AR248131A1 (no) |
| AU (1) | AU627622B2 (no) |
| CA (1) | CA2013961A1 (no) |
| EG (1) | EG20055A (no) |
| FI (1) | FI904447A0 (no) |
| IE (1) | IE902837A1 (no) |
| IL (1) | IL93857A (no) |
| NO (1) | NO177096C (no) |
| NZ (1) | NZ233059A (no) |
| PH (1) | PH26429A (no) |
| PT (1) | PT95361A (no) |
| ZA (1) | ZA902344B (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0498722T3 (da) * | 1991-02-07 | 1998-03-09 | Roussel Uclaf | Nye bicycliske nitrogenforbindelser substitueret med en benzylgruppe, fremgangsmåde til deres fremstilling, de opnåede nye intermediærer, deres anvendelse som lægemidler og de pharmaceutiske præparater som de indgår i |
| FR2672596B1 (fr) * | 1991-02-07 | 1995-07-13 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2672595B1 (fr) * | 1991-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments. |
| MX9200299A (es) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
| FR2680510B1 (fr) * | 1991-08-20 | 1995-06-23 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2680509B1 (fr) * | 1991-08-20 | 1995-07-28 | Roussel Uclaf | Derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant . |
| EP0613879A4 (en) * | 1991-05-20 | 1995-05-03 | Tsumura & Co | PHELLODENDRIN ANALOGS AND TYPE IV ALLERGY SUPPRESSOR CONTAINING THEM AS ACTIVE INGREDIENTS. |
| JP3276762B2 (ja) * | 1993-12-28 | 2002-04-22 | 日本臓器製薬株式会社 | イソキノリン誘導体を含有する医薬組成物 |
| CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
| GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| JP2001506653A (ja) | 1996-12-18 | 2001-05-22 | ニューロゲン コーポレイション | Ｃｒｆレセプターと相互作用するイソキノリナミン及びフタルアジナミン誘導体 |
| WO2002030888A2 (en) | 2000-10-10 | 2002-04-18 | Calyx Therapeutics, Inc. | Tricyclic compounds and uses thereof |
| WO2008020302A2 (en) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
| JP2008302070A (ja) | 2007-06-08 | 2008-12-18 | Tokai Ind Sewing Mach Co Ltd | 刺繍ミシン及びその制御方法 |
| CN109810171B (zh) * | 2017-11-21 | 2020-12-01 | 首都医科大学 | 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用 |
| US20230095341A1 (en) * | 2020-01-29 | 2023-03-30 | Georgetown University | Compositions and methods for treating neurodegenerative, myodegenerative, and lysosomal storage disorders |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5637229B2 (no) * | 1972-08-15 | 1981-08-29 | ||
| GB1453606A (en) * | 1972-12-22 | 1976-10-27 | Siphar Sa | Method for synthesis of plus-minus-glaziovine |
| FR2257275A1 (en) * | 1974-01-16 | 1975-08-08 | Houdet Antoine | Alkaloid salts of para chlorophenoxy isobutyric acid - useful for inhibiting thromboses and as hyperlipaemics |
| FR2368277A1 (fr) * | 1976-10-21 | 1978-05-19 | Sobio Lab | Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique |
| DE2717001C2 (de) * | 1977-04-18 | 1984-06-20 | Karl O. Helm Ag, 2000 Hamburg | Arzneimittel mit antithrombotischer Wirkung |
| US4115389A (en) * | 1977-05-02 | 1978-09-19 | Bristol-Myers Company | Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline |
| US4521601A (en) * | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
| HU183479B (en) * | 1981-06-16 | 1984-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin |
| DE3233424A1 (de) * | 1982-09-09 | 1984-03-15 | Hoechst Ag, 6230 Frankfurt | Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| US4613668A (en) * | 1983-12-22 | 1986-09-23 | The United States Of America As Represented By The Department Of Health And Human Services | Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl |
| DK8386A (da) * | 1986-01-15 | 1987-07-09 | Tpo Pharmachim | Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme |
| JPS63174932A (ja) * | 1987-01-16 | 1988-07-19 | Kaken Shiyouyaku Kk | 抗血小板凝集剤 |
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
-
1989
- 1989-09-19 US US07/409,521 patent/US4956371A/en not_active Ceased
-
1990
- 1990-03-23 IL IL9385790A patent/IL93857A/en not_active IP Right Cessation
- 1990-03-23 NZ NZ233059A patent/NZ233059A/xx unknown
- 1990-03-27 ZA ZA902344A patent/ZA902344B/xx unknown
- 1990-04-03 PH PH40318A patent/PH26429A/en unknown
- 1990-04-05 CA CA002013961A patent/CA2013961A1/en not_active Abandoned
- 1990-04-27 EP EP19900108030 patent/EP0422328A3/en not_active Withdrawn
- 1990-04-27 AR AR90316736A patent/AR248131A1/es active
- 1990-05-06 EG EG26790A patent/EG20055A/xx active
- 1990-06-02 CN CN90104103A patent/CN1050381A/zh active Pending
- 1990-08-07 IE IE283790A patent/IE902837A1/en unknown
- 1990-09-10 FI FI904447A patent/FI904447A0/fi not_active Application Discontinuation
- 1990-09-18 AU AU62652/90A patent/AU627622B2/en not_active Ceased
- 1990-09-18 NO NO904059A patent/NO177096C/no unknown
- 1990-09-19 KR KR1019900014835A patent/KR940000162B1/ko not_active IP Right Cessation
- 1990-09-19 JP JP2251661A patent/JPH03145469A/ja active Pending
- 1990-09-19 PT PT95361A patent/PT95361A/pt not_active Application Discontinuation
-
1992
- 1992-01-27 US US07/825,974 patent/USRE34630E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AR248131A1 (es) | 1995-06-30 |
| ZA902344B (en) | 1991-01-30 |
| IL93857A0 (en) | 1990-12-23 |
| AU627622B2 (en) | 1992-08-27 |
| EP0422328A2 (en) | 1991-04-17 |
| US4956371A (en) | 1990-09-11 |
| PT95361A (pt) | 1991-07-05 |
| FI904447A0 (fi) | 1990-09-10 |
| KR940000162B1 (ko) | 1994-01-08 |
| CA2013961A1 (en) | 1991-03-19 |
| IL93857A (en) | 1994-11-28 |
| PH26429A (en) | 1992-07-15 |
| NO904059D0 (no) | 1990-09-18 |
| AU6265290A (en) | 1991-03-28 |
| NZ233059A (en) | 1991-10-25 |
| CN1050381A (zh) | 1991-04-03 |
| JPH03145469A (ja) | 1991-06-20 |
| USRE34630E (en) | 1994-06-07 |
| KR910006235A (ko) | 1991-04-27 |
| NO177096B (no) | 1995-04-10 |
| EP0422328A3 (en) | 1991-10-02 |
| IE902837A1 (en) | 1991-03-27 |
| EG20055A (en) | 1997-03-27 |
| NO904059L (no) | 1991-03-20 |
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