FR2368277A1 - Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique - Google Patents

Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique

Info

Publication number
FR2368277A1
FR2368277A1 FR7631658A FR7631658A FR2368277A1 FR 2368277 A1 FR2368277 A1 FR 2368277A1 FR 7631658 A FR7631658 A FR 7631658A FR 7631658 A FR7631658 A FR 7631658A FR 2368277 A1 FR2368277 A1 FR 2368277A1
Authority
FR
France
Prior art keywords
isoquinoleine
vasoactive
new hydrogen
spasmolytic activity
hydrogen derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7631658A
Other languages
English (en)
Other versions
FR2368277B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOBIO LAB
Original Assignee
SOBIO LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOBIO LAB filed Critical SOBIO LAB
Priority to FR7631658A priority Critical patent/FR2368277A1/fr
Priority to DE19782817083 priority patent/DE2817083A1/de
Priority to BE186976A priority patent/BE866208A/fr
Priority to AT284478A priority patent/AT356110B/de
Priority to JP4678578A priority patent/JPS54141786A/ja
Priority to NL7804202A priority patent/NL7804202A/xx
Priority to CH425478A priority patent/CH642632A5/de
Publication of FR2368277A1 publication Critical patent/FR2368277A1/fr
Application granted granted Critical
Publication of FR2368277B1 publication Critical patent/FR2368277B1/fr
Priority to US06/300,957 priority patent/US4442108A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Composés représentés par la formule générale :
FR7631658A 1976-10-21 1976-10-21 Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique Granted FR2368277A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR7631658A FR2368277A1 (fr) 1976-10-21 1976-10-21 Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
DE19782817083 DE2817083A1 (de) 1976-10-21 1978-04-19 Benzylisochinolin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate
AT284478A AT356110B (de) 1976-10-21 1978-04-20 Verfahren zur herstellung von neuen benzyliso- chinolinderivaten und ihren saeureadditions- salzen
JP4678578A JPS54141786A (en) 1976-10-21 1978-04-20 Hydrogenated benzylisoquinoline derivatives* their manufacture*medical composition containing them and intermediate compounds for their manufacture
BE186976A BE866208A (fr) 1976-10-21 1978-04-20 Derives de l'isoquinoleine hydrogenee
NL7804202A NL7804202A (nl) 1976-10-21 1978-04-20 Gehydrogeneerde benzylisochinoline derivaten met spas- molytische en bloeddrukverlagende werking, werkwijze ter bereiding van deze verbindingen alsmede farmaceu- tisch preparaat dat een zodanige verbinding bevat.
CH425478A CH642632A5 (de) 1976-10-21 1978-04-20 Benzylisochinolin-derivate, verfahren zu ihrer herstellung und die verwendung dieser verbindungen in arzneipraeparaten.
US06/300,957 US4442108A (en) 1976-10-21 1981-09-10 Hydrogenated isoquinolines and peripheral vascular disease treating compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7631658A FR2368277A1 (fr) 1976-10-21 1976-10-21 Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique

Publications (2)

Publication Number Publication Date
FR2368277A1 true FR2368277A1 (fr) 1978-05-19
FR2368277B1 FR2368277B1 (fr) 1979-02-23

Family

ID=9179024

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7631658A Granted FR2368277A1 (fr) 1976-10-21 1976-10-21 Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique

Country Status (8)

Country Link
US (1) US4442108A (fr)
JP (1) JPS54141786A (fr)
AT (1) AT356110B (fr)
BE (1) BE866208A (fr)
CH (1) CH642632A5 (fr)
DE (1) DE2817083A1 (fr)
FR (1) FR2368277A1 (fr)
NL (1) NL7804202A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142070A1 (fr) * 1983-10-25 1985-05-22 BASF Aktiengesellschaft Procédé de préparation de N-méthyl-homovératryl-amine
EP0617022A1 (fr) * 1993-02-25 1994-09-28 Banyu Pharmaceutical Co., Ltd. 6,7-dialkyl-3,4-dihydroisoquinolin-3-ol, procédé pour sa préparation et procédé utilisant ce composé pour la préparation de 6,7-dialkyl1,2,3,4-tétrahydroisoquinolin-8-ol

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU183479B (en) * 1981-06-16 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
EP1023269A4 (fr) * 1997-09-30 2001-06-27 Molecular Design Int Agonistes de beta3-adrenorecepteurs, compositions d'agonistes et procedes d'utilisation
US6846492B2 (en) 2000-02-23 2005-01-25 Ciba Specialty Chemicals Corporation Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
AU2001233760A1 (en) * 2000-02-23 2001-09-03 Ciba Specialty Chemicals Holding Inc. Use of phenylethylamine derivatives for the anitmicrobial treatment of surfaces
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2928769A (en) * 1957-07-22 1960-03-15 Strong Cobb And Company Inc Production of controlled release medicaments
IL33480A (en) * 1968-12-10 1973-03-30 Tanabe Seiyaku Co 6,7-diacyloxy-tetrahydro-isoquinolines and their preparation
HU167246B (fr) * 1973-01-25 1975-09-27
JPS5734275B2 (fr) * 1973-07-30 1982-07-22

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0142070A1 (fr) * 1983-10-25 1985-05-22 BASF Aktiengesellschaft Procédé de préparation de N-méthyl-homovératryl-amine
EP0617022A1 (fr) * 1993-02-25 1994-09-28 Banyu Pharmaceutical Co., Ltd. 6,7-dialkyl-3,4-dihydroisoquinolin-3-ol, procédé pour sa préparation et procédé utilisant ce composé pour la préparation de 6,7-dialkyl1,2,3,4-tétrahydroisoquinolin-8-ol
US5498717A (en) * 1993-02-25 1996-03-12 Banyu Pharmaceutical Co., Ltd. 6,7-dialkoxy-3,4-diydroisoquinolin-8-yl compounds

Also Published As

Publication number Publication date
ATA284478A (de) 1979-09-15
FR2368277B1 (fr) 1979-02-23
JPS54141786A (en) 1979-11-05
JPS64394B2 (fr) 1989-01-06
DE2817083A1 (de) 1979-11-15
US4442108A (en) 1984-04-10
BE866208A (fr) 1978-10-20
CH642632A5 (de) 1984-04-30
AT356110B (de) 1980-04-10
NL7804202A (nl) 1979-10-23

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