FI890282A0 - Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi

Info

Publication number
FI890282A0
FI890282A0 FI890282A FI890282A FI890282A0 FI 890282 A0 FI890282 A0 FI 890282A0 FI 890282 A FI890282 A FI 890282A FI 890282 A FI890282 A FI 890282A FI 890282 A0 FI890282 A0 FI 890282A0
Authority
FI
Finland
Prior art keywords
hydroxycalciferol
didehydro
derivatives
preparation
therapeutically useful
Prior art date
Application number
FI890282A
Other languages
English (en)
Swedish (sv)
Other versions
FI92193B (fi
FI890282A (fi
FI92193C (fi
Inventor
Enrico Giuseppe Baggiolini
John Joseph Partridge
Shian-Jan Shiuey
Gary Arthur Truitt
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI890282A0 publication Critical patent/FI890282A0/fi
Publication of FI890282A publication Critical patent/FI890282A/fi
Publication of FI92193B publication Critical patent/FI92193B/fi
Application granted granted Critical
Publication of FI92193C publication Critical patent/FI92193C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
FI890282A 1988-01-20 1989-01-19 Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi FI92193C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14586788 1988-01-20
US07/145,867 US4804502A (en) 1988-01-20 1988-01-20 Vitamin D compounds

Publications (4)

Publication Number Publication Date
FI890282A0 true FI890282A0 (fi) 1989-01-19
FI890282A FI890282A (fi) 1989-07-21
FI92193B FI92193B (fi) 1994-06-30
FI92193C FI92193C (fi) 1994-10-10

Family

ID=22514903

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890282A FI92193C (fi) 1988-01-20 1989-01-19 Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi

Country Status (23)

Country Link
US (1) US4804502A (fi)
EP (1) EP0326875B1 (fi)
JP (1) JPH0764805B2 (fi)
KR (1) KR960009118B1 (fi)
AR (1) AR246253A1 (fi)
AT (1) ATE74125T1 (fi)
AU (1) AU621851B2 (fi)
CA (1) CA1314906C (fi)
DE (1) DE58901003D1 (fi)
DK (1) DK171966B1 (fi)
ES (1) ES2032613T3 (fi)
FI (1) FI92193C (fi)
GR (1) GR3004785T3 (fi)
HU (1) HU201736B (fi)
IE (1) IE60920B1 (fi)
IL (1) IL88988A (fi)
MC (1) MC1997A1 (fi)
NO (1) NO174547C (fi)
NZ (1) NZ227642A (fi)
PH (1) PH24442A (fi)
PT (1) PT89485B (fi)
YU (1) YU47204B (fi)
ZA (1) ZA8922B (fi)

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ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
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GB9017890D0 (en) 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
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US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
ES2200238T3 (es) * 1991-01-08 2004-03-01 Bone Care International, Inc. Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2.
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ATE143007T1 (de) * 1991-07-05 1996-10-15 Duphar Int Res Vitamin-d derivat, verfahren zu dessen herstellung sowie zwischenprodukte dafür
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
EP0580968B1 (en) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Vitamin D3 fluorinated analogs
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (fi) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
AU7295696A (en) * 1995-10-27 1997-05-22 F. Hoffmann-La Roche Ag Pharmaceutical composition for treating osteoporosis
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
US6017908A (en) * 1997-05-16 2000-01-25 Women And Infants Hospital 3-EPI vitamin D2 compounds and uses thereof
WO1998051663A2 (en) * 1997-05-16 1998-11-19 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
JP2002505668A (ja) 1997-05-16 2002-02-19 ウィメン アンド インファンツ ホスピタル 環状エーテルビタミンＤ３化合物、１α（ＯＨ）３−エピ−ビタミンＤ３化合物及びそれらの使用法
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
EP1064000B1 (en) 1998-03-27 2011-07-06 Oregon Health & Science University Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
EP1314427A4 (en) * 2000-08-17 2006-05-03 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT FOR THE TREATMENT OF OSTEOPOROSIS
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
JP2008540513A (ja) * 2005-05-10 2008-11-20 ダーミプソル リミテッド スキンケアのための組成物及び方法
NZ563270A (en) 2005-05-10 2010-11-26 Dermipsor Ltd Calcipotriol, polyethylene oxide topical compositions for the treatment of hyperproliferative epidermal diseases
JP4882050B2 (ja) 2006-03-15 2012-02-22 日本マイクロバイオファーマ株式会社 インデン誘導体の製造方法およびその製造中間体
CA2668544A1 (en) 2006-11-02 2008-05-08 Mercian Corporation Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
EP2393494A1 (en) * 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
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AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury

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FR2384755A1 (fr) * 1977-03-24 1978-10-20 Wisconsin Alumni Res Found Derives de la vitamine d3 ayant une activite antivitamine d
FR2426044A2 (fr) * 1978-05-19 1979-12-14 Wisconsin Research Foundation Derives de la vitamine d3 ayant une activite anti-vitamine d
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ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
IE60920B1 (en) 1994-08-24
ES2032613T3 (es) 1993-02-16
IL88988A (en) 1993-08-18
JPH029860A (ja) 1990-01-12
IL88988A0 (en) 1989-08-15
AR246253A1 (es) 1994-07-29
PT89485A (pt) 1989-10-04
NO890240L (no) 1989-07-21
NO174547C (no) 1994-05-25
FI92193B (fi) 1994-06-30
EP0326875A1 (de) 1989-08-09
HU201736B (en) 1990-12-28
NO174547B (no) 1994-02-14
DK19689D0 (da) 1989-01-17
KR960009118B1 (en) 1996-07-13
NZ227642A (en) 1991-06-25
NO890240D0 (no) 1989-01-19
EP0326875B1 (de) 1992-03-25
DK171966B1 (da) 1997-09-01
DE58901003D1 (de) 1992-04-30
YU47204B (sh) 1995-01-31
AU2864389A (en) 1989-07-20
PT89485B (pt) 1993-12-31
FI890282A (fi) 1989-07-21
IE890156L (en) 1989-07-20
GR3004785T3 (fi) 1993-04-28
YU11889A (en) 1991-04-30
JPH0764805B2 (ja) 1995-07-12
PH24442A (en) 1990-06-25
FI92193C (fi) 1994-10-10
US4804502A (en) 1989-02-14
AU621851B2 (en) 1992-03-26
ATE74125T1 (de) 1992-04-15
MC1997A1 (fr) 1990-01-26
HUT49316A (en) 1989-09-28
CA1314906C (en) 1993-03-23
ZA8922B (en) 1989-09-27
KR890011837A (ko) 1989-08-22
DK19689A (da) 1989-07-21

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Owner name: F. HOFFMANN-LA ROCHE AG