MX347126B - Derivado de 23-ino-vitamina d3. - Google Patents

Derivado de 23-ino-vitamina d3.

Info

Publication number
MX347126B
MX347126B MX2013004389A MX2013004389A MX347126B MX 347126 B MX347126 B MX 347126B MX 2013004389 A MX2013004389 A MX 2013004389A MX 2013004389 A MX2013004389 A MX 2013004389A MX 347126 B MX347126 B MX 347126B
Authority
MX
Mexico
Prior art keywords
carbon atoms
alkyl group
group
vitamin
derivative
Prior art date
Application number
MX2013004389A
Other languages
English (en)
Other versions
MX2013004389A (es
Inventor
Saito Hiroshi
Ochiai Eiji
Takagi Kenichiro
Komiyama Masato
Chida Takayuki
Fujita Mariko
Imaizumi Keiichiro
Kaneko Toshiyuki
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Publication of MX2013004389A publication Critical patent/MX2013004389A/es
Publication of MX347126B publication Critical patent/MX347126B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporciona un nuevo derivado de la vitamina D3, útil como agente terapéutico para la osteoporosis. Se proporciona un derivado de la vitamina D3 representado por la siguiente fórmula (1), o un solvato medicinalmente aceptable de él: (ver Fórmula) en donde R1 representa un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 6 átomos de carbono, un grupo alquilcarboniloxialquilo donde cada alquilo tiene de 1 a 6 átomos de carbono, o un grupo arilcarboniloxialquilo donde el arilo tiene de 6 a 10 átomos de carbono y el alquilo tiene de 1 a 6 átomos de carbono; R2 representa un átomo de hidrógeno o un grupo alquilo que tiene de 1 a 6 átomos de carbono o, junto con el otro R2 y el átomo de carbono al cual están unidos, puede formar un grupo alquilo cíclico que tiene de 3 a 6 átomos de carbono; R3 representa un grupo alquilo que tiene de 1 a 6 átomos de carbono o, junto con el otro R3 y el átomo de carbono al cual están unidos, puede formar un grupo alquilo cíclico que tiene de 3 a 6 átomos de carbono; X representa un átomo de oxígeno o un grupo metileno; y n representa un entero de 1 ó 2.
MX2013004389A 2010-10-25 2011-10-24 Derivado de 23-ino-vitamina d3. MX347126B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010238524 2010-10-25
PCT/JP2011/074414 WO2012057068A1 (ja) 2010-10-25 2011-10-24 ２３－イン－ビタミンｄ３誘導体

Publications (2)

Publication Number Publication Date
MX2013004389A MX2013004389A (es) 2013-05-22
MX347126B true MX347126B (es) 2017-04-17

Family

ID=45993776

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004389A MX347126B (es) 2010-10-25 2011-10-24 Derivado de 23-ino-vitamina d3.

Country Status (21)

Country Link
US (2) US9006220B2 (es)
EP (1) EP2634171B8 (es)
JP (1) JP5738307B2 (es)
KR (1) KR101853518B1 (es)
CN (2) CN103180293B (es)
AR (1) AR083541A1 (es)
AU (1) AU2011321624B2 (es)
BR (1) BR112013009647A2 (es)
CA (1) CA2815501C (es)
DK (1) DK2634171T3 (es)
ES (1) ES2541719T3 (es)
HK (2) HK1184133A1 (es)
HU (1) HUE025554T2 (es)
IL (1) IL225630A0 (es)
MX (1) MX347126B (es)
PL (1) PL2634171T3 (es)
PT (1) PT2634171E (es)
RU (1) RU2558362C2 (es)
SG (1) SG189427A1 (es)
TW (1) TWI503120B (es)
WO (1) WO2012057068A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013162047A1 (ja) * 2012-04-24 2013-10-31 帝人ファーマ株式会社 二次性副甲状腺機能亢進症治療剤
JP2020143008A (ja) * 2019-03-05 2020-09-10 達也 楠堂 新規褐色脂肪細胞分化誘導剤
CN114681467B (zh) * 2022-03-30 2024-03-12 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物在制备抗肿瘤药物中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804502A (en) 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
SG70009A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Vitamin d3 analogs
GB9611603D0 (en) * 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
TW473469B (en) 1997-06-25 2002-01-21 Teijin Ltd Vitamin D3-derivatives and agents for treating inflammatory respiratory diseases prepared from the same
US6359152B2 (en) * 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5939406A (en) * 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6538145B2 (en) * 1998-02-24 2003-03-25 Chugai Seiyaku Kabushiki Kaisha 24-hydroxy vitamin D derivatives
JP4357114B2 (ja) * 1998-02-24 2009-11-04 中外製薬株式会社 ２４−ヒドロキシビタミンｄ誘導体
EP1070704A4 (en) * 1998-04-10 2001-11-07 Chugai Pharmaceutical Co Ltd VITAMIN D DERIVATIVES SUBSTITUTED IN THE 2 BETA POSITION
KR20020092955A (ko) * 2000-02-28 2002-12-12 쥬가이 세이야쿠 가부시키가이샤 2α위치에 치환기를 갖는 비타민 Ｄ 유도체
US20080318911A1 (en) * 2004-09-24 2008-12-25 Bioxell S.P.A. 20-Cyclopropyl, 26,27-Alkyl/Haloalkyl Vitamin D3 Compounds and Methods of Use Thereof
JP2009013154A (ja) * 2006-09-29 2009-01-22 Teijin Pharma Ltd ２−置換−１４−エピ−プレビタミンｄ３誘導体

Also Published As

Publication number Publication date
CN103180293B (zh) 2015-06-17
US20150148552A1 (en) 2015-05-28
AU2011321624B2 (en) 2015-03-26
JP5738307B2 (ja) 2015-06-24
KR101853518B1 (ko) 2018-04-30
CA2815501C (en) 2018-10-16
HK1211281A1 (zh) 2016-05-20
AU2011321624A1 (en) 2013-05-09
TWI503120B (zh) 2015-10-11
DK2634171T3 (en) 2015-07-13
HUE025554T2 (en) 2016-02-29
US9079843B2 (en) 2015-07-14
AR083541A1 (es) 2013-03-06
EP2634171B1 (en) 2015-07-01
HK1184133A1 (en) 2014-01-17
KR20140001874A (ko) 2014-01-07
AU2011321624A8 (en) 2013-09-12
TW201223531A (en) 2012-06-16
CN103180293A (zh) 2013-06-26
BR112013009647A2 (pt) 2016-07-12
JPWO2012057068A1 (ja) 2014-05-12
SG189427A1 (en) 2013-05-31
RU2013124033A (ru) 2014-12-10
ES2541719T3 (es) 2015-07-24
MX2013004389A (es) 2013-05-22
US20130210781A1 (en) 2013-08-15
CN104829510B (zh) 2016-05-04
EP2634171A4 (en) 2013-11-13
EP2634171A1 (en) 2013-09-04
US9006220B2 (en) 2015-04-14
PL2634171T3 (pl) 2015-12-31
EP2634171B8 (en) 2016-01-13
CN104829510A (zh) 2015-08-12
PT2634171E (pt) 2015-09-16
IL225630A0 (en) 2013-06-27
CA2815501A1 (en) 2012-05-03
RU2558362C2 (ru) 2015-08-10
WO2012057068A1 (ja) 2012-05-03

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