YU47204B - Derivati didehidro-vitamina d3 - Google Patents

Derivati didehidro-vitamina d3

Info

Publication number
YU47204B
YU47204B YU11889A YU11889A YU47204B YU 47204 B YU47204 B YU 47204B YU 11889 A YU11889 A YU 11889A YU 11889 A YU11889 A YU 11889A YU 47204 B YU47204 B YU 47204B
Authority
YU
Yugoslavia
Prior art keywords
didehidro
vitamina
derivati
denotes hydrogen
didehydro
Prior art date
Application number
YU11889A
Other languages
English (en)
Other versions
YU11889A (en
Inventor
E.G. Baggiolini
J.J. Partrige
S.-J. Shiuey
G.A. Truitt
M.R. Uskoković
Original Assignee
F. Hoffmann-La Roche & Co. Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Ag. filed Critical F. Hoffmann-La Roche & Co. Ag.
Publication of YU11889A publication Critical patent/YU11889A/xx
Publication of YU47204B publication Critical patent/YU47204B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

DERIVATI DIDEHIDRO-VITAMINA D3, jedinjenje formule: u kojoj R1 označava vodonik ili hidroksi i R2 označava vodonik ili fluor. Prijava sadrži još 1 nezavisan zahtev.
YU11889A 1988-01-20 1989-01-19 Derivati didehidro-vitamina d3 YU47204B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/145,867 US4804502A (en) 1988-01-20 1988-01-20 Vitamin D compounds

Publications (2)

Publication Number Publication Date
YU11889A YU11889A (en) 1991-04-30
YU47204B true YU47204B (sh) 1995-01-31

Family

ID=22514903

Family Applications (1)

Application Number Title Priority Date Filing Date
YU11889A YU47204B (sh) 1988-01-20 1989-01-19 Derivati didehidro-vitamina d3

Country Status (23)

Country Link
US (1) US4804502A (sh)
EP (1) EP0326875B1 (sh)
JP (1) JPH0764805B2 (sh)
KR (1) KR960009118B1 (sh)
AR (1) AR246253A1 (sh)
AT (1) ATE74125T1 (sh)
AU (1) AU621851B2 (sh)
CA (1) CA1314906C (sh)
DE (1) DE58901003D1 (sh)
DK (1) DK171966B1 (sh)
ES (1) ES2032613T3 (sh)
FI (1) FI92193C (sh)
GR (1) GR3004785T3 (sh)
HU (1) HU201736B (sh)
IE (1) IE60920B1 (sh)
IL (1) IL88988A (sh)
MC (1) MC1997A1 (sh)
NO (1) NO174547C (sh)
NZ (1) NZ227642A (sh)
PH (1) PH24442A (sh)
PT (1) PT89485B (sh)
YU (1) YU47204B (sh)
ZA (1) ZA8922B (sh)

Families Citing this family (53)

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US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5258559A (en) * 1990-11-27 1993-11-02 Hoffmann-La Roche Inc. Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
WO1992012165A1 (en) * 1991-01-08 1992-07-23 Lunar Corporation METHODS FOR PREPARATION AND USE OF 1α,24-DIHYDROXY VITAMIN D¿2?
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
DE69213844T2 (de) * 1991-07-05 1997-04-10 Duphar Int Res Vitamin-D Derivat, Verfahren zu dessen Herstellung sowie Zwischenprodukte dafür
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
ES2091515T3 (es) * 1992-05-20 1996-11-01 Hoffmann La Roche Analogos fluorados de la vitamina d3.
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (sh) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6121469A (en) * 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
AU7295696A (en) * 1995-10-27 1997-05-22 F. Hoffmann-La Roche Ag Pharmaceutical composition for treating osteoporosis
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
US6100294A (en) * 1997-05-16 2000-08-08 Women And Infants Hospital Cyclic ether vitamin D3 compounds, 1α(OH) 3-epi-vitamin D3 compounds and uses thereof
EP0981514B1 (en) * 1997-05-16 2006-04-05 Woman & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
US20010007907A1 (en) * 1997-05-16 2001-07-12 Women And Infants Hospital 3-epi compounds of vitamin d3 and uses thereof
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
ES2368824T3 (es) 1998-03-27 2011-11-22 Oregon Health & Science University Vitamina d y sus análogos en el tratamiento de tumores y otros desórdenes hiperproliferativos.
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
EP1879449A4 (en) * 2005-05-10 2009-12-16 Dermipsor Ltd SKIN CARE COMPOSITIONS AND METHODS
BRPI0609630A2 (pt) * 2005-05-10 2010-04-20 Dermipsor Ltd composições e métodos para tratamento de doenças epidérmicas hiperproliferativas
CN101405249B (zh) * 2006-03-15 2013-05-29 日本迈科洛生物制药有限公司 茚衍生物的制备方法及其制备中间体
KR20090082257A (ko) 2006-11-02 2009-07-29 메루샹가부시키가이샤 1-히드록시-19-노르시클로비타민 ｄ 유도체의 제조방법 및 그 제조 중간체
CA2981549A1 (en) * 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
SG10201404883YA (en) 2009-08-14 2014-10-30 Berg Llc Vitamin d3 and analogs thereof for treating alopecia
PL2634171T3 (pl) 2010-10-25 2015-12-31 Teijin Ltd 23-ynowa pochodna witaminy D3
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury

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DE2812741C2 (de) * 1977-03-24 1987-03-12 Wisconsin Alumni Research Foundation, Madison, Wis. Vitamin D↓3↓-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel
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US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
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US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
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ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
FI890282A (fi) 1989-07-21
FI92193C (fi) 1994-10-10
ES2032613T3 (es) 1993-02-16
FI890282A0 (fi) 1989-01-19
EP0326875B1 (de) 1992-03-25
DK19689D0 (da) 1989-01-17
DK171966B1 (da) 1997-09-01
ATE74125T1 (de) 1992-04-15
US4804502A (en) 1989-02-14
DE58901003D1 (de) 1992-04-30
NO890240L (no) 1989-07-21
YU11889A (en) 1991-04-30
HUT49316A (en) 1989-09-28
MC1997A1 (fr) 1990-01-26
IE60920B1 (en) 1994-08-24
NO174547C (no) 1994-05-25
KR890011837A (ko) 1989-08-22
NZ227642A (en) 1991-06-25
AU621851B2 (en) 1992-03-26
GR3004785T3 (sh) 1993-04-28
NO174547B (no) 1994-02-14
PH24442A (en) 1990-06-25
FI92193B (fi) 1994-06-30
HU201736B (en) 1990-12-28
EP0326875A1 (de) 1989-08-09
AU2864389A (en) 1989-07-20
AR246253A1 (es) 1994-07-29
JPH0764805B2 (ja) 1995-07-12
DK19689A (da) 1989-07-21
IE890156L (en) 1989-07-20
PT89485A (pt) 1989-10-04
PT89485B (pt) 1993-12-31
JPH029860A (ja) 1990-01-12
NO890240D0 (no) 1989-01-19
ZA8922B (en) 1989-09-27
KR960009118B1 (en) 1996-07-13
IL88988A (en) 1993-08-18
CA1314906C (en) 1993-03-23
IL88988A0 (en) 1989-08-15

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