NO174547C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive didehydro-vitamin-D3-derivater - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive didehydro-vitamin-D3-derivater

Info

Publication number
NO174547C
NO174547C NO890240A NO890240A NO174547C NO 174547 C NO174547 C NO 174547C NO 890240 A NO890240 A NO 890240A NO 890240 A NO890240 A NO 890240A NO 174547 C NO174547 C NO 174547C
Authority
NO
Norway
Prior art keywords
vitamin
derivatives
therapeutically active
analogous process
preparing therapeutically
Prior art date
Application number
NO890240A
Other languages
English (en)
Other versions
NO174547B (no
NO890240L (no
NO890240D0 (no
Inventor
Enrico Giuseppe Baggiolini
John Joseph Partridge
Shian-Jan Shiuey
Gary Arthur Truitt
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO890240D0 publication Critical patent/NO890240D0/no
Publication of NO890240L publication Critical patent/NO890240L/no
Publication of NO174547B publication Critical patent/NO174547B/no
Publication of NO174547C publication Critical patent/NO174547C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NO890240A 1988-01-20 1989-01-19 Analogifremgangsmåte ved fremstilling av terapeutisk aktive didehydro-vitamin-D3-derivater NO174547C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/145,867 US4804502A (en) 1988-01-20 1988-01-20 Vitamin D compounds

Publications (4)

Publication Number Publication Date
NO890240D0 NO890240D0 (no) 1989-01-19
NO890240L NO890240L (no) 1989-07-21
NO174547B NO174547B (no) 1994-02-14
NO174547C true NO174547C (no) 1994-05-25

Family

ID=22514903

Family Applications (1)

Application Number Title Priority Date Filing Date
NO890240A NO174547C (no) 1988-01-20 1989-01-19 Analogifremgangsmåte ved fremstilling av terapeutisk aktive didehydro-vitamin-D3-derivater

Country Status (23)

Country Link
US (1) US4804502A (no)
EP (1) EP0326875B1 (no)
JP (1) JPH0764805B2 (no)
KR (1) KR960009118B1 (no)
AR (1) AR246253A1 (no)
AT (1) ATE74125T1 (no)
AU (1) AU621851B2 (no)
CA (1) CA1314906C (no)
DE (1) DE58901003D1 (no)
DK (1) DK171966B1 (no)
ES (1) ES2032613T3 (no)
FI (1) FI92193C (no)
GR (1) GR3004785T3 (no)
HU (1) HU201736B (no)
IE (1) IE60920B1 (no)
IL (1) IL88988A (no)
MC (1) MC1997A1 (no)
NO (1) NO174547C (no)
NZ (1) NZ227642A (no)
PH (1) PH24442A (no)
PT (1) PT89485B (no)
YU (1) YU47204B (no)
ZA (1) ZA8922B (no)

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US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5258559A (en) * 1990-11-27 1993-11-02 Hoffmann-La Roche Inc. Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
EP0550702B1 (en) * 1991-01-08 1999-05-06 Bone Care International, Inc. METHODS FOR PREPARATION AND USE OF 1$g(a),24-DIHYDROXY VITAMIN D 2?
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
IL99368A (en) * 1991-09-02 1996-01-19 Teva Pharma Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
EP0580968B1 (en) * 1992-05-20 1996-08-28 F. Hoffmann-La Roche Ag Vitamin D3 fluorinated analogs
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5753638A (en) * 1992-10-07 1998-05-19 Hoffmann-La Roche Inc. Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (no) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5547947A (en) * 1993-03-11 1996-08-20 Hoffmann-La Roche Inc. Methods of treatment
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6121469A (en) * 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
WO1997016193A1 (en) * 1995-10-27 1997-05-09 F. Hoffmann-La Roche Ag Pharmaceutical composition for treating osteoporosis
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
WO1998051678A1 (en) 1997-05-16 1998-11-19 Women & Infants Hospital CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
AU7497798A (en) * 1997-05-16 1998-12-08 F. Hoffmann-La Roche Ag 3-epi compounds of vitamin d3 and uses thereof
CA2288710A1 (en) * 1997-05-16 1998-11-19 Women & Infants Hospital 3-epi vitamin d2 compounds and uses thereof
US6087350A (en) * 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
WO1999012894A1 (en) * 1997-09-08 1999-03-18 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
US5919986A (en) * 1997-10-17 1999-07-06 Hoffmann-La Roche Inc. D-homo vitamin D3 derivatives
AU762481C (en) * 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
WO2006120682A2 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for treating hyperproliferative epidermal diseases
US20030220307A1 (en) * 2000-08-17 2003-11-27 Akira Kawase Remedial agent for osteoporosis
GB0305332D0 (en) * 2003-03-10 2003-04-09 Leuven K U Res & Dev Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) * 2004-10-15 2004-11-17 Leuven K U Res & Dev Bioactive vitamin D analogues
US20060003950A1 (en) * 2004-06-30 2006-01-05 Bone Care International, Inc. Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
EP1879449A4 (en) * 2005-05-10 2009-12-16 Dermipsor Ltd SKIN CARE COMPOSITIONS AND METHODS
WO2007105773A1 (ja) 2006-03-15 2007-09-20 Mercian Corporation インデン誘導体の製造方法およびその製造中間体
US20110319644A1 (en) 2006-11-02 2011-12-29 Asako Toyoda Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
JP5932339B2 (ja) * 2009-01-27 2016-06-08 バーグ エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体
IN2012DN02137A (no) 2009-08-14 2015-08-07 Berg Biosystems Llc
EP2634171B8 (en) 2010-10-25 2016-01-13 Teijin Pharma Limited 23-yne-vitamin d3 derivative
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
WO2017209934A1 (en) 2016-05-13 2017-12-07 Case Western Reserve University Autophagy activators for treating or preventing skin injury

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FR2384755A1 (fr) * 1977-03-24 1978-10-20 Wisconsin Alumni Res Found Derives de la vitamine d3 ayant une activite antivitamine d
DE2920092A1 (de) * 1978-05-19 1979-11-29 Wisconsin Alumni Res Found Antivitamin d-verbindungen und diese enthaltende pharmazeutische zusammensetzungen
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) * 1983-03-21 1985-04-02 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) * 1984-01-30 1985-03-19 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 isomers
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
FI890282A (fi) 1989-07-21
IE60920B1 (en) 1994-08-24
IL88988A0 (en) 1989-08-15
PT89485B (pt) 1993-12-31
NO174547B (no) 1994-02-14
JPH0764805B2 (ja) 1995-07-12
FI890282A0 (fi) 1989-01-19
IE890156L (en) 1989-07-20
HUT49316A (en) 1989-09-28
EP0326875B1 (de) 1992-03-25
DK171966B1 (da) 1997-09-01
DK19689A (da) 1989-07-21
AU2864389A (en) 1989-07-20
YU47204B (sh) 1995-01-31
ATE74125T1 (de) 1992-04-15
NO890240L (no) 1989-07-21
JPH029860A (ja) 1990-01-12
IL88988A (en) 1993-08-18
KR890011837A (ko) 1989-08-22
MC1997A1 (fr) 1990-01-26
EP0326875A1 (de) 1989-08-09
FI92193C (fi) 1994-10-10
ES2032613T3 (es) 1993-02-16
AR246253A1 (es) 1994-07-29
CA1314906C (en) 1993-03-23
GR3004785T3 (no) 1993-04-28
DE58901003D1 (de) 1992-04-30
YU11889A (en) 1991-04-30
AU621851B2 (en) 1992-03-26
US4804502A (en) 1989-02-14
ZA8922B (en) 1989-09-27
DK19689D0 (da) 1989-01-17
HU201736B (en) 1990-12-28
PT89485A (pt) 1989-10-04
NZ227642A (en) 1991-06-25
PH24442A (en) 1990-06-25
KR960009118B1 (en) 1996-07-13
FI92193B (fi) 1994-06-30
NO890240D0 (no) 1989-01-19

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