NO173652C - Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt indazol-3-karboksylsyrederivat - Google Patents

Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt indazol-3-karboksylsyrederivat

Info

Publication number
NO173652C
NO173652C NO893078A NO893078A NO173652C NO 173652 C NO173652 C NO 173652C NO 893078 A NO893078 A NO 893078A NO 893078 A NO893078 A NO 893078A NO 173652 C NO173652 C NO 173652C
Authority
NO
Norway
Prior art keywords
preparing
carboxylic acid
acid derivative
therapeutically active
analogous procedure
Prior art date
Application number
NO893078A
Other languages
English (en)
Other versions
NO173652B (no
NO893078L (no
NO893078D0 (no
Inventor
Tatsuya Kon
Shiro Kato
Toshiya Morie
Tadahiko Karasawa
Naoyuki Yoshida
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of NO893078D0 publication Critical patent/NO893078D0/no
Publication of NO893078L publication Critical patent/NO893078L/no
Publication of NO173652B publication Critical patent/NO173652B/no
Publication of NO173652C publication Critical patent/NO173652C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO893078A 1988-07-29 1989-07-28 Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt indazol-3-karboksylsyrederivat NO173652C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19190488 1988-07-29
JP32298688 1988-12-20

Publications (4)

Publication Number Publication Date
NO893078D0 NO893078D0 (no) 1989-07-28
NO893078L NO893078L (no) 1990-01-30
NO173652B NO173652B (no) 1993-10-04
NO173652C true NO173652C (no) 1994-01-12

Family

ID=26506977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO893078A NO173652C (no) 1988-07-29 1989-07-28 Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt indazol-3-karboksylsyrederivat

Country Status (11)

Country Link
US (1) US5017573A (no)
EP (1) EP0358903A3 (no)
JP (2) JPH0655738B2 (no)
KR (1) KR910002839A (no)
AU (1) AU621642B2 (no)
DK (1) DK374289A (no)
FI (1) FI893592A7 (no)
HU (1) HU204816B (no)
NO (1) NO173652C (no)
NZ (1) NZ230068A (no)
PT (1) PT91287B (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
US5989586A (en) * 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
WO1996038420A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amino group
ES2156616T3 (es) * 1995-07-28 2001-07-01 Dainippon Pharmaceutical Co (r)-5-bromo-n-(1-etil-4-metilhexahidro-1h-1,4-diazepan-6-il)-2-metoxi-6-metilamino-3-piridincarboxamida, procedimiento para su produccion y composicion medicinal que la contiene.
US6046185A (en) * 1996-07-11 2000-04-04 Inflazyme Pharmaceuticals Ltd. 6,7-oxygenated steroids and uses related thereto
GB9721139D0 (en) 1997-10-07 1997-12-03 Glaxo Group Ltd Medicaments
US5914405A (en) * 1997-10-07 1999-06-22 Eli Lilly And Company Process for preparing 3-substituted indazoles
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
CA2464333C (en) * 2001-10-26 2011-07-26 University Of Connecticut Heteroindanes: a new class of potent cannabimimetic ligands
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TW200621237A (en) 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
ATE431824T1 (de) * 2004-11-05 2009-06-15 Theravance Inc Chinolinon-carboxamid-verbindungen
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
NZ560828A (en) * 2005-03-02 2011-01-28 Theravance Inc Quinolinone compounds as 5-HT4 receptor agonists
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
RU2608458C2 (ru) 2009-05-20 2017-01-18 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Антагонисты серотониновых 5-нт3-рецепторов для применения при лечении вестибулярных нарушений с повреждениями
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1069122A (en) * 1975-11-11 1980-01-01 W.R. Grace And Co. Preparation of dialkali metal hexahydropyrimidine-1, 3-diacetate and dialkalimetal 5-hydroxyhexahydropyrimidine-1, 3-diacetate
JPS5925785B2 (ja) * 1976-01-01 1984-06-21 山之内製薬株式会社 新規なカルボン酸アミド誘導体
US4207327A (en) * 1977-08-19 1980-06-10 A. H. Robins Company, Inc. N-(4-Pyrazolidinyl)benzamides and their amino precursors
DE3166987D1 (en) * 1980-09-18 1984-12-06 Asahi Chemical Ind 3-aminoindazole derivatives and process for preparation thereof
CA1220141A (en) * 1981-06-13 1987-04-07 John R. Fozard Treatment of migraine with tropyl benzoate derivatives
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
ATE61054T1 (de) * 1985-01-23 1991-03-15 Hoechst Roussel Pharma 3-piperidinyl- 1h-indazole, verfahren zu deren herstellung und deren anwendung als arzneimittel.
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
EP0200444B1 (en) * 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-ht antagonist activity
GB8520616D0 (en) * 1985-08-16 1985-09-25 Beecham Group Plc Compounds
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
DE3687980T2 (de) * 1986-01-07 1993-06-17 Beecham Group Plc Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
EP0235878A3 (en) * 1986-01-16 1989-06-14 Beecham Group Plc Novel compounds
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
EP0410509A1 (en) * 1989-07-25 1991-01-30 Duphar International Research B.V New substituted 1H-indazole-3-carboxamides
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles

Also Published As

Publication number Publication date
NO173652B (no) 1993-10-04
JPH02256670A (ja) 1990-10-17
AU621642B2 (en) 1992-03-19
HUT52093A (en) 1990-06-28
JP2898139B2 (ja) 1999-05-31
NZ230068A (en) 1991-07-26
PT91287A (pt) 1990-02-08
JPH0592959A (ja) 1993-04-16
DK374289A (da) 1990-01-30
HU204816B (en) 1992-02-28
FI893592A0 (fi) 1989-07-27
JPH0655738B2 (ja) 1994-07-27
EP0358903A2 (en) 1990-03-21
NO893078L (no) 1990-01-30
US5017573A (en) 1991-05-21
AU3910389A (en) 1990-02-01
NO893078D0 (no) 1989-07-28
FI893592A7 (fi) 1990-01-30
PT91287B (pt) 1995-03-01
DK374289D0 (da) 1989-07-28
KR910002839A (ko) 1991-02-26
EP0358903A3 (en) 1992-03-04

Similar Documents

Publication Publication Date Title
NO173652C (no) Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt indazol-3-karboksylsyrederivat
NO174547C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive didehydro-vitamin-D3-derivater
NO176759C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
NO174385C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive spiro-substituerte glutamid-derivater
FI890652A7 (fi) Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
NO174101C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive triazolderivater
NO175371C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive aminosyrederivater
FI883050L (fi) Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi
NO178619C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive di-t-butylfenoler
NO175429C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive 16-dehydro-vitamin-D3-derivater
NO180084C (no) Analogifremgangsmåte ved fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater
NO176275C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazinonderivater
FI880869A7 (fi) Menetelmä terapeuttisesti aktiivisten tetratsolijohdannaisten valmistamiseksi
NO174959C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive N-aminobutyl-N-fenyl-arylamidderivater
NO173334C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
NO178967C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazin-derivater
NO173784C (no) Anaslogifremgangsmaate for fremstilling av terapeutisk aktive tieno-tri-azolo-diazepinderivater
FI890123L (fi) Menetelmä valmistaa terapeuttisesti vaikuttavia indolyylipiperidiiniyhdisteitä
NO176100C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive oksodihydropyridyl- og oksodihydropyridazinylkromanderivater
NO174200C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-imino-6-polyfluoralkoksybenzotiazol-forbindelser
FI882002L (fi) Menetelmä terapeuttisesti aktiivisten fenyylipiperidiinijohdannaisten valmistamiseksi
NO176105C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive peptidderivater
NO174463C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyrrolidinderivater
NO173332C (no) Analogifremgangsm}te for fremstilling av terapeutisk aktive tetrahydrofuranderivater
NO176242C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 5-substituerte ornithinderivater