NO180084C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater - Google Patents
Analogifremgangsmåte ved fremstilling av terapeutisk aktive 1,4-dihydropyridinderivaterInfo
- Publication number
- NO180084C NO180084C NO930306A NO930306A NO180084C NO 180084 C NO180084 C NO 180084C NO 930306 A NO930306 A NO 930306A NO 930306 A NO930306 A NO 930306A NO 180084 C NO180084 C NO 180084C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- therapeutically active
- analogous process
- dihydropyridine derivatives
- dihydropyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9001752A NL9001752A (nl) | 1990-08-02 | 1990-08-02 | Nieuwe 1,4-dihydropyridinederivaten. |
PCT/EP1991/001442 WO1992002503A1 (en) | 1990-08-02 | 1991-07-31 | Novel 1,4-dihydropyridine derivatives |
Publications (4)
Publication Number | Publication Date |
---|---|
NO930306D0 NO930306D0 (no) | 1993-01-29 |
NO930306L NO930306L (no) | 1993-01-29 |
NO180084B NO180084B (no) | 1996-11-04 |
NO180084C true NO180084C (no) | 1997-02-12 |
Family
ID=19857506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO930306A NO180084C (no) | 1990-08-02 | 1993-01-29 | Analogifremgangsmåte ved fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater |
Country Status (13)
Country | Link |
---|---|
US (1) | US5378718A (no) |
EP (1) | EP0541634A1 (no) |
JP (1) | JPH05509094A (no) |
AU (1) | AU655192B2 (no) |
CA (1) | CA2088251A1 (no) |
FI (1) | FI930429A (no) |
IE (1) | IE912754A1 (no) |
IL (1) | IL99030A0 (no) |
NL (1) | NL9001752A (no) |
NO (1) | NO180084C (no) |
NZ (1) | NZ239234A (no) |
WO (1) | WO1992002503A1 (no) |
ZA (1) | ZA916058B (no) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995013812A1 (de) * | 1993-11-17 | 1995-05-26 | Byk Nederland Bv | Verwendung substituierter 1,4-dihydropyridine zur senkung des augeninnendruckes |
AU8430098A (en) * | 1998-07-23 | 2000-02-14 | Ing-Jun Chen | Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity |
SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
PE20221914A1 (es) | 2011-12-28 | 2022-12-23 | Global Blood Therapeutics Inc | Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido |
EP2797597B1 (en) | 2011-12-28 | 2020-02-26 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
US10100043B2 (en) | 2013-03-15 | 2018-10-16 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
AU2014237330A1 (en) | 2013-03-15 | 2015-09-17 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
CN112500338A (zh) | 2013-03-15 | 2021-03-16 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
KR101971385B1 (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
AU2015214182B2 (en) | 2014-02-07 | 2020-04-30 | Global Blood Therapeutics, Inc. | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
WO2020072377A1 (en) | 2018-10-01 | 2020-04-09 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
JPS58185562A (ja) * | 1982-04-22 | 1983-10-29 | Taisho Pharmaceut Co Ltd | 1,4−ジヒドロピリジン誘導体 |
DE3248548A1 (de) * | 1982-12-29 | 1984-07-05 | Heinrich Mack Nachf., 7918 Illertissen | Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JPS6289662A (ja) * | 1985-06-14 | 1987-04-24 | Sankyo Co Ltd | 1,4−ジヒドロピリジン誘導体 |
DE3521761A1 (de) * | 1985-06-19 | 1987-01-02 | Bayer Ag | Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
JPH02501736A (ja) * | 1986-12-24 | 1990-06-14 | ベリンガー マンハイム イタリア エッセ ピ ア | 新規なアラルキル‐1,4‐ジヒドロピリジンおよびその製造法、ならびにそれを含有する製薬組成物 |
DE3833893A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte |
DE3833892A1 (de) * | 1988-10-05 | 1990-04-12 | Bayer Ag | Basische 4-aryl-dhp-amide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
-
1990
- 1990-08-02 NL NL9001752A patent/NL9001752A/nl not_active Application Discontinuation
-
1991
- 1991-07-31 JP JP3512770A patent/JPH05509094A/ja active Pending
- 1991-07-31 EP EP91913914A patent/EP0541634A1/en not_active Withdrawn
- 1991-07-31 US US07/965,270 patent/US5378718A/en not_active Expired - Fee Related
- 1991-07-31 WO PCT/EP1991/001442 patent/WO1992002503A1/en not_active Application Discontinuation
- 1991-07-31 AU AU82801/91A patent/AU655192B2/en not_active Ceased
- 1991-07-31 CA CA002088251A patent/CA2088251A1/en not_active Abandoned
- 1991-08-01 IL IL99030A patent/IL99030A0/xx unknown
- 1991-08-01 ZA ZA916058A patent/ZA916058B/xx unknown
- 1991-08-02 IE IE275491A patent/IE912754A1/en unknown
- 1991-08-02 NZ NZ239234A patent/NZ239234A/en unknown
-
1993
- 1993-01-29 NO NO930306A patent/NO180084C/no unknown
- 1993-02-01 FI FI930429A patent/FI930429A/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI930429A0 (fi) | 1993-02-01 |
NO930306D0 (no) | 1993-01-29 |
ZA916058B (en) | 1992-06-24 |
NZ239234A (en) | 1994-06-27 |
EP0541634A1 (en) | 1993-05-19 |
JPH05509094A (ja) | 1993-12-16 |
AU655192B2 (en) | 1994-12-08 |
IL99030A0 (en) | 1992-07-15 |
AU8280191A (en) | 1992-03-02 |
WO1992002503A1 (en) | 1992-02-20 |
US5378718A (en) | 1995-01-03 |
CA2088251A1 (en) | 1992-02-03 |
NO180084B (no) | 1996-11-04 |
FI930429A (fi) | 1993-02-01 |
NL9001752A (nl) | 1992-03-02 |
NO930306L (no) | 1993-01-29 |
IE912754A1 (en) | 1992-02-12 |
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