NL9001752A - Nieuwe 1,4-dihydropyridinederivaten. - Google Patents

Nieuwe 1,4-dihydropyridinederivaten. Download PDF

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Publication number
NL9001752A
NL9001752A NL9001752A NL9001752A NL9001752A NL 9001752 A NL9001752 A NL 9001752A NL 9001752 A NL9001752 A NL 9001752A NL 9001752 A NL9001752 A NL 9001752A NL 9001752 A NL9001752 A NL 9001752A
Authority
NL
Netherlands
Prior art keywords
ppm
arom
ethyl acetate
compound
yield
Prior art date
Application number
NL9001752A
Other languages
English (en)
Dutch (nl)
Original Assignee
Cedona Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedona Pharm Bv filed Critical Cedona Pharm Bv
Priority to NL9001752A priority Critical patent/NL9001752A/nl
Priority to US07/965,270 priority patent/US5378718A/en
Priority to EP91913914A priority patent/EP0541634A1/en
Priority to PCT/EP1991/001442 priority patent/WO1992002503A1/en
Priority to CA002088251A priority patent/CA2088251A1/en
Priority to AU82801/91A priority patent/AU655192B2/en
Priority to JP3512770A priority patent/JPH05509094A/ja
Priority to ZA916058A priority patent/ZA916058B/xx
Priority to IL99030A priority patent/IL99030A0/xx
Priority to NZ239234A priority patent/NZ239234A/en
Priority to IE275491A priority patent/IE912754A1/en
Publication of NL9001752A publication Critical patent/NL9001752A/nl
Priority to NO930306A priority patent/NO180084C/no
Priority to FI930429A priority patent/FI930429A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL9001752A 1990-08-02 1990-08-02 Nieuwe 1,4-dihydropyridinederivaten. NL9001752A (nl)

Priority Applications (13)

Application Number Priority Date Filing Date Title
NL9001752A NL9001752A (nl) 1990-08-02 1990-08-02 Nieuwe 1,4-dihydropyridinederivaten.
AU82801/91A AU655192B2 (en) 1990-08-02 1991-07-31 Novel 1,4-dihydropyridine derivatives
EP91913914A EP0541634A1 (en) 1990-08-02 1991-07-31 1,4-dihydropyridine derivatives
PCT/EP1991/001442 WO1992002503A1 (en) 1990-08-02 1991-07-31 Novel 1,4-dihydropyridine derivatives
CA002088251A CA2088251A1 (en) 1990-08-02 1991-07-31 1-4-dihydropyridine derivatives
US07/965,270 US5378718A (en) 1990-08-02 1991-07-31 1,4-dihydropyridine derivatives
JP3512770A JPH05509094A (ja) 1990-08-02 1991-07-31 新規１，４―ジヒドロピリジン誘導体
ZA916058A ZA916058B (en) 1990-08-02 1991-08-01 Novel 1,4-dihydropyridine derivatives
IL99030A IL99030A0 (en) 1990-08-02 1991-08-01 1,4-dihydropyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ239234A NZ239234A (en) 1990-08-02 1991-08-02 1,4-dihydropyridine derivatives and pharmcaeutical compositions
IE275491A IE912754A1 (en) 1990-08-02 1991-08-02 Novel 1,4-dihydropyridine derivatives
NO930306A NO180084C (no) 1990-08-02 1993-01-29 Analogifremgangsmåte ved fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater
FI930429A FI930429A (fi) 1990-08-02 1993-02-01 Nya 1,4-dihyropyridinderivat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9001752 1990-08-02
NL9001752A NL9001752A (nl) 1990-08-02 1990-08-02 Nieuwe 1,4-dihydropyridinederivaten.

Publications (1)

Publication Number Publication Date
NL9001752A true NL9001752A (nl) 1992-03-02

Family

ID=19857506

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9001752A NL9001752A (nl) 1990-08-02 1990-08-02 Nieuwe 1,4-dihydropyridinederivaten.

Country Status (13)

Country Link
US (1) US5378718A (no)
EP (1) EP0541634A1 (no)
JP (1) JPH05509094A (no)
AU (1) AU655192B2 (no)
CA (1) CA2088251A1 (no)
FI (1) FI930429A (no)
IE (1) IE912754A1 (no)
IL (1) IL99030A0 (no)
NL (1) NL9001752A (no)
NO (1) NO180084C (no)
NZ (1) NZ239234A (no)
WO (1) WO1992002503A1 (no)
ZA (1) ZA916058B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013812A1 (de) * 1993-11-17 1995-05-26 Byk Nederland Bv Verwendung substituierter 1,4-dihydropyridine zur senkung des augeninnendruckes
AU8430098A (en) * 1998-07-23 2000-02-14 Ing-Jun Chen Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
PE20221914A1 (es) 2011-12-28 2022-12-23 Global Blood Therapeutics Inc Compuestos de benzaldehido sustituidos y metodos para su uso en incrementar la oxigenacion del tejido
EP2797597B1 (en) 2011-12-28 2020-02-26 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
AU2014237330A1 (en) 2013-03-15 2015-09-17 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN112500338A (zh) 2013-03-15 2021-03-16 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
KR101971385B1 (ko) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AU2015214182B2 (en) 2014-02-07 2020-04-30 Global Blood Therapeutics, Inc. Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
GB1455502A (en) * 1973-02-20 1976-11-10 Yamanouchi Pharma Co Ltd 1,4-dihydropyridine derivatives
JPS58185562A (ja) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS6289662A (ja) * 1985-06-14 1987-04-24 Sankyo Co Ltd １，４−ジヒドロピリジン誘導体
DE3521761A1 (de) * 1985-06-19 1987-01-02 Bayer Ag Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
JPH02501736A (ja) * 1986-12-24 1990-06-14 ベリンガー　マンハイム　イタリア　エッセ　ピ　ア 新規なアラルキル‐１，４‐ジヒドロピリジンおよびその製造法、ならびにそれを含有する製薬組成物
DE3833893A1 (de) * 1988-10-05 1990-04-12 Bayer Ag Verwendung von basischen nitro-phenyl-dihydropyridin-amiden als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung ueber neue zwischenprodukte
DE3833892A1 (de) * 1988-10-05 1990-04-12 Bayer Ag Basische 4-aryl-dhp-amide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
FI930429A0 (fi) 1993-02-01
NO930306D0 (no) 1993-01-29
ZA916058B (en) 1992-06-24
NZ239234A (en) 1994-06-27
EP0541634A1 (en) 1993-05-19
NO180084C (no) 1997-02-12
JPH05509094A (ja) 1993-12-16
AU655192B2 (en) 1994-12-08
IL99030A0 (en) 1992-07-15
AU8280191A (en) 1992-03-02
WO1992002503A1 (en) 1992-02-20
US5378718A (en) 1995-01-03
CA2088251A1 (en) 1992-02-03
NO180084B (no) 1996-11-04
FI930429A (fi) 1993-02-01
NO930306L (no) 1993-01-29
IE912754A1 (en) 1992-02-12

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