ES2090184T3 - 4-amino-delta 4-esteroides y su utilizacion como inhibidores de la 5alfa-reductasa. - Google Patents

4-amino-delta 4-esteroides y su utilizacion como inhibidores de la 5alfa-reductasa.

Info

Publication number
ES2090184T3
ES2090184T3 ES91112796T ES91112796T ES2090184T3 ES 2090184 T3 ES2090184 T3 ES 2090184T3 ES 91112796 T ES91112796 T ES 91112796T ES 91112796 T ES91112796 T ES 91112796T ES 2090184 T3 ES2090184 T3 ES 2090184T3
Authority
ES
Spain
Prior art keywords
steroids
reductase
delta
inhibitors
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91112796T
Other languages
English (en)
Inventor
Philip M Weintraub
Joseph P Burkhart
Thomas R Blohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/671,555 external-priority patent/US5143909A/en
Priority claimed from US07/720,900 external-priority patent/US5120840A/en
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2090184T3 publication Critical patent/ES2090184T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A 4-AMINO-DELTA4-ESTEROIDES QUE SON UTILES COMO INHIBIDORES DE 5ALFA-REDUCTASA. LOS COMPUESTOS SE PREPARAN POR LA REACCION DE UN ESTEROIDE 4-AZIDO CON TRIFENILFOSFINA UN SOLVENTE INERTE ACUOSO CON CALENTAMIENTO.
ES91112796T 1990-08-01 1991-07-30 4-amino-delta 4-esteroides y su utilizacion como inhibidores de la 5alfa-reductasa. Expired - Lifetime ES2090184T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56104190A 1990-08-01 1990-08-01
US07/671,555 US5143909A (en) 1991-03-19 1991-03-19 Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,900 US5120840A (en) 1990-08-01 1991-07-02 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Publications (1)

Publication Number Publication Date
ES2090184T3 true ES2090184T3 (es) 1996-10-16

Family

ID=27415841

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91112796T Expired - Lifetime ES2090184T3 (es) 1990-08-01 1991-07-30 4-amino-delta 4-esteroides y su utilizacion como inhibidores de la 5alfa-reductasa.

Country Status (17)

Country Link
EP (1) EP0469548B1 (es)
JP (1) JP3021819B2 (es)
KR (1) KR100186812B1 (es)
AT (1) ATE138931T1 (es)
AU (1) AU637247B2 (es)
CA (1) CA2048242C (es)
DE (1) DE69119992T2 (es)
DK (1) DK0469548T3 (es)
ES (1) ES2090184T3 (es)
FI (1) FI102377B (es)
GR (1) GR3020672T3 (es)
HU (1) HU210046B (es)
IE (1) IE75198B1 (es)
IL (1) IL98999A (es)
NO (1) NO180339C (es)
NZ (1) NZ239142A (es)
PT (1) PT98518B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5356935A (en) * 1993-12-13 1994-10-18 Eli Lilly And Company Reduced phenanthrenes
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
EP3023433A1 (en) 2009-02-05 2016-05-25 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780070A (en) * 1972-09-21 1973-12-18 Schering Corp 4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) * 1979-05-02 1983-09-20 Thomas R. Blohm STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) * 1987-05-15 1987-06-17 Erba Farmitalia 4-amino-androstenedione derivatives

Also Published As

Publication number Publication date
FI102377B1 (fi) 1998-11-30
IE75198B1 (en) 1997-08-27
PT98518B (pt) 1999-01-29
AU8136291A (en) 1992-02-06
EP0469548A2 (en) 1992-02-05
IL98999A0 (en) 1992-07-15
DK0469548T3 (da) 1996-06-24
IL98999A (en) 1995-10-31
HU210046B (en) 1995-01-30
NO180339C (no) 1997-04-02
JP3021819B2 (ja) 2000-03-15
CA2048242C (en) 2003-04-15
IE912705A1 (en) 1992-02-12
FI913657A (fi) 1992-02-02
HU912558D0 (en) 1992-01-28
PT98518A (pt) 1992-06-30
EP0469548A3 (en) 1992-06-03
JPH06172379A (ja) 1994-06-21
DE69119992T2 (de) 1997-02-06
KR100186812B1 (ko) 1999-04-01
KR920004409A (ko) 1992-03-27
HUT59156A (en) 1992-04-28
EP0469548B1 (en) 1996-06-05
GR3020672T3 (en) 1996-10-31
FI913657A0 (fi) 1991-07-31
NO912981L (no) 1992-02-03
ATE138931T1 (de) 1996-06-15
NO912981D0 (no) 1991-07-31
CA2048242A1 (en) 1992-02-02
NO180339B (no) 1996-12-23
NZ239142A (en) 1994-05-26
DE69119992D1 (de) 1996-07-11
AU637247B2 (en) 1993-05-20
FI102377B (fi) 1998-11-30

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