KR860008176A - 8-페닐크산틴류의 제조방법 - Google Patents
8-페닐크산틴류의 제조방법 Download PDFInfo
- Publication number
- KR860008176A KR860008176A KR1019860003211A KR860003211A KR860008176A KR 860008176 A KR860008176 A KR 860008176A KR 1019860003211 A KR1019860003211 A KR 1019860003211A KR 860003211 A KR860003211 A KR 860003211A KR 860008176 A KR860008176 A KR 860008176A
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- KR
- South Korea
- Prior art keywords
- compound
- hydrogen
- alkyl
- formula
- nitro
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 상화 방지제의 존재하에서, 하기식(Ⅱ)의 화합물을 고리화하거나, 하기 기중 Y가 C3-6알케닐렌옥시 또는 C3-6알키닐렌옥신인 경우 하기식(Ⅶ)의 화합물을 하기식(Ⅷ)의 화합물과 반응시키거나, 하기식(Ⅹ)의 화합물을 고리화하고, 그 후 결과의 하기식(Ⅰ)의 화합물의 기중 X1내지 X6를 각각 상이한 X1내지 X6로 전환시키거나 하기식(Ⅰ)의 화합물의 염 또는 그 용매 화합물을 형성하는 단계로 구성되는 하기식(Ⅰ)의 화합물, 이것의 염 또는 이것의 용매 화합제조하는 방법.상기식에서, X1및 X3는 서로 상이하거나 동일한 수소, C1-6알킬, C2-6알케닐 또는 아릴링에 C1-6알킬, C1-6알콕시, 히드록시, 할로, 니트로, 아미노 아지도, 및 시아노로부터 선택된 적어도 하나의 치환제에 의해 치환된 C7-12아르알킬로서, X1및 X2가 모두 수소가 아님을 조건으로 하여 ; X3및 X4중 어느하나는 수소, C1-6알킬, 트리플루오로메틸, C1-6알콕시, 할로, 니트로, 아미노,C1-6알콕시카르보닐 또는 카르복시이며, 다른 하나는 -Y-Z인데, Y는 C2-6알케닐렌, C3-6알케닐 렌옥시, C2-6알키닐렌 또는 C3-6알킬닐렌옥시이며, Z는 카르복시, 설포닐 또는 포스포닐 또는 C1-9알킬에스테르, C7-12아르알킬에스테르 또는 C6-12아릴에스테르이거나 혹은 5-테트라졸릴이며 ; X5및 X6는 서로 상이하거나 동일한 산소 또는 황이며 ; X1 3및 X1 4중 어느하나는 상기의 X3및 X4중 어느하나로서 정의괸 바와 같으며, 다른 하나는 히드록시이며 ; L은 이탈기이며 ; Y1은 C3-6알케닐렌 또는 C3-6알키닐렌이며 ; A 및 B중 어느 하나는 수소이며, 다른 하나는 3-X3)-4-(X4)-벤조일(X3및 X4는 상기에서 정의된 바와 같음)이다.
- 제1항에 있어서, X1및 X2중 어느하나 혹은 모두는 아릴에 C1-6알킬, C1-6알콕시, 히드록시, 할로, 니트로, 아미노, 아지도 및 시아노보쿠터 선택된 적어도 하나의 치환체에 의해 임의적으로 치환된 벤질인 것을 특징으로 하는 제조방법.
- 제2항에서, 상기 임의의 치환체는 메틸, 메톡시, 히드록시, 클로로, 니트로, 아미노, 아지도 및 시아노로부터 선택되는 것을 특징으로 하는 제조방법.
- 제1항 내지 제3항중 어느 한항에 있어서, X1및 X2는 수소 또는 C1-6알킬인 것을 특징으로 하는 제조방법.
- 제1항 내지 제4항중 어느 한항에 있어서, Y는 비닐렌 또는 아세틸렌인 것을 특징으로 하는 제조방법.
- 제1항 내지 제5항중 어느 한항에 있어서, X3는 수소이며, X4는 -Y-Z인데, Y는 비닐렌이고 Z는 카르복시 또는 이것의 C1-6에스테르인 것을 특징으로 하는 제조방법.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858510758A GB8510758D0 (en) | 1985-04-27 | 1985-04-27 | Compounds |
GB8510758 | 1985-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR860008176A true KR860008176A (ko) | 1986-11-12 |
Family
ID=10578311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860003211A KR860008176A (ko) | 1985-04-27 | 1986-04-25 | 8-페닐크산틴류의 제조방법 |
Country Status (22)
Country | Link |
---|---|
US (2) | US4879296A (ko) |
EP (1) | EP0203721B1 (ko) |
JP (1) | JPH0788381B2 (ko) |
KR (1) | KR860008176A (ko) |
AP (1) | AP22A (ko) |
AT (1) | ATE77088T1 (ko) |
AU (1) | AU581507B2 (ko) |
CA (1) | CA1286666C (ko) |
DE (1) | DE3685608T2 (ko) |
DK (1) | DK169271B1 (ko) |
ES (1) | ES8800945A1 (ko) |
FI (1) | FI861750A (ko) |
GB (1) | GB8510758D0 (ko) |
GR (1) | GR861107B (ko) |
HU (1) | HUT41027A (ko) |
IE (1) | IE60022B1 (ko) |
IL (1) | IL78605A (ko) |
MC (1) | MC1743A1 (ko) |
NO (1) | NO861643L (ko) |
NZ (1) | NZ215948A (ko) |
PT (1) | PT82451B (ko) |
ZA (1) | ZA863132B (ko) |
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1985
- 1985-04-27 GB GB858510758A patent/GB8510758D0/en active Pending
-
1986
- 1986-04-23 IL IL78605A patent/IL78605A/xx unknown
- 1986-04-24 PT PT82451A patent/PT82451B/pt unknown
- 1986-04-24 NZ NZ215948A patent/NZ215948A/xx unknown
- 1986-04-24 DK DK190486A patent/DK169271B1/da not_active IP Right Cessation
- 1986-04-24 AU AU56707/86A patent/AU581507B2/en not_active Expired
- 1986-04-25 ES ES554380A patent/ES8800945A1/es not_active Expired
- 1986-04-25 HU HU861730A patent/HUT41027A/hu unknown
- 1986-04-25 GR GR861107A patent/GR861107B/el unknown
- 1986-04-25 EP EP86303171A patent/EP0203721B1/en not_active Expired - Lifetime
- 1986-04-25 FI FI861750A patent/FI861750A/fi not_active Application Discontinuation
- 1986-04-25 US US06/856,719 patent/US4879296A/en not_active Expired - Lifetime
- 1986-04-25 NO NO861643A patent/NO861643L/no unknown
- 1986-04-25 DE DE8686303171T patent/DE3685608T2/de not_active Expired - Lifetime
- 1986-04-25 MC MC861834A patent/MC1743A1/xx unknown
- 1986-04-25 AT AT86303171T patent/ATE77088T1/de not_active IP Right Cessation
- 1986-04-25 AP APAP/P/1986/000036A patent/AP22A/en active
- 1986-04-25 KR KR1019860003211A patent/KR860008176A/ko not_active Application Discontinuation
- 1986-04-25 ZA ZA863132A patent/ZA863132B/xx unknown
- 1986-04-25 JP JP61094957A patent/JPH0788381B2/ja not_active Expired - Lifetime
- 1986-04-25 CA CA000507576A patent/CA1286666C/en not_active Expired - Fee Related
- 1986-04-28 IE IE110486A patent/IE60022B1/en not_active IP Right Cessation
-
1989
- 1989-08-29 US US07/400,464 patent/US4981857A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES8800945A1 (es) | 1987-12-01 |
EP0203721B1 (en) | 1992-06-10 |
ES554380A0 (es) | 1987-12-01 |
AP8600036A0 (en) | 1986-02-01 |
IE60022B1 (en) | 1994-05-18 |
AP22A (en) | 1988-07-20 |
EP0203721A2 (en) | 1986-12-03 |
IL78605A (en) | 1989-07-31 |
US4981857A (en) | 1991-01-01 |
HUT41027A (en) | 1987-03-30 |
JPS6242986A (ja) | 1987-02-24 |
PT82451A (en) | 1986-05-01 |
CA1286666C (en) | 1991-07-23 |
EP0203721A3 (en) | 1988-06-08 |
DK190486A (da) | 1986-10-28 |
MC1743A1 (fr) | 1987-02-26 |
DK190486D0 (da) | 1986-04-24 |
ZA863132B (en) | 1987-12-30 |
NZ215948A (en) | 1989-10-27 |
NO861643L (no) | 1986-10-28 |
AU5670786A (en) | 1986-10-30 |
DK169271B1 (da) | 1994-09-26 |
PT82451B (pt) | 1988-11-30 |
IE861104L (en) | 1986-10-27 |
FI861750A (fi) | 1986-10-28 |
AU581507B2 (en) | 1989-02-23 |
DE3685608D1 (de) | 1992-07-16 |
FI861750A0 (fi) | 1986-04-25 |
IL78605A0 (en) | 1986-08-31 |
GB8510758D0 (en) | 1985-06-05 |
GR861107B (en) | 1986-08-04 |
US4879296A (en) | 1989-11-07 |
ATE77088T1 (de) | 1992-06-15 |
DE3685608T2 (de) | 1992-12-24 |
JPH0788381B2 (ja) | 1995-09-27 |
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