KR910000619A - γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법 - Google Patents

γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법 Download PDF

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KR910000619A
KR910000619A KR1019900008672A KR900008672A KR910000619A KR 910000619 A KR910000619 A KR 910000619A KR 1019900008672 A KR1019900008672 A KR 1019900008672A KR 900008672 A KR900008672 A KR 900008672A KR 910000619 A KR910000619 A KR 910000619A
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South Korea
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formula
alkyl
carbon atoms
compound
keto
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KR1019900008672A
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라둔쯔 한스-엑카르트
울리히 라이씨그 한스
Original Assignee
호이만, 쉬틀러
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
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Publication of KR910000619A publication Critical patent/KR910000619A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(Ⅰ)의 γ-케토-δ-아미노산 유도체의 거울 이성체 선택 제조방법에 있어서,
    상기식에서, R1은 아미노 보호기 또는 H이고, R2는 임의적으로 -OH, -COOH, -CONH2또는 -NH2에 의해 단일 또는 이치환될 수 있는 또는 CH2그룹이 임의로 -S-에 의해 대치될 수 있는 탄소수 1 내지 5을 가지는 알킬기, 비치환 또는 탄소수 1 내지 5를 함유하는 알킬 또는 알콕시, 할로켄, 히드록시 또는 아미노에 의해 다일 치환 또는 다치환된 페닐 또는 시클로헥실, 또는 페닐알킬 또는 시클로헥실알킬, 또는 Het-알킬이고, 여기서, Het는 질소수 1 내지 4를 가지는 포화 또는 불포화된 5- 또는 6원 헤테로시클릭 라디칼이고 이것은 벤젠고리와 융합될 수 있고, 그리고 알킬은 탄소수 1 내지 5를 가지는 알킬렌 그룹이며, 그리고 R3과 R4는 각기 독립적으로 H 또는 탄소수 1 내지 5를 가지는 알킬이고, 일반식 (Ⅱ)의 화합물을 트리알킬클로로실란을 사용하여
    일반식(Ⅲ)의 화합물로 전환하고
    일반식(Ⅲ)이 화합물을 이어서 일반식 N2CH2COOR4(R4≠H)의 디아조아세테이트와 반응시켜 일반식(Ⅳ)의 시클로프로판 화하물을 만들고
    그리고 일반식(Ⅳ)의 화합물을 고리 개환 그리고 실릴 그룹의 제거 그리고 적절한 경우 검화에 의해 일반식(Ⅰ)의 화합물로 전환시키는 것을 특징으로 하는, 일반식(Ⅱ) 내지 (Ⅳ)의 R1, R2, R3및 R4그룹은 가히 표시한 뜻을 가지며 그리고 R5은 탄소수 1 내지 5를 가지는 알킬 그룹인 일반식(Ⅰ)의 γ-케토-δ-아미노산 유도체의 거울 이성체 선택 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900008672A 1989-06-19 1990-06-13 γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법 KR910000619A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3919898A DE3919898A1 (de) 1989-06-19 1989-06-19 Verfahren zur enantioselektiven herstellung von (gamma)-keto-(delta)-aminosaeurederivaten
DEP3919898.7 1989-06-19

Publications (1)

Publication Number Publication Date
KR910000619A true KR910000619A (ko) 1991-01-29

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ID=6382995

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900008672A KR910000619A (ko) 1989-06-19 1990-06-13 γ-케토-δ-아미노산 유도체의 거울이성체 선택 제조방법

Country Status (7)

Country Link
US (1) US5095114A (ko)
EP (1) EP0408881A3 (ko)
JP (1) JPH0348646A (ko)
KR (1) KR910000619A (ko)
DE (1) DE3919898A1 (ko)
FI (1) FI903058A0 (ko)
HU (1) HUT56812A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE137215T1 (de) * 1991-10-18 1996-05-15 Suntory Ltd 2-(2,3-dicarboxycyclopropyl)-glycin und ein verfahren zu ihrer herstellung
DE4228084C1 (de) * 1992-08-24 1993-12-23 Suedzucker Ag Verfahren zur Herstellung von N-Acylderivaten der 5-Aminolävulinsäure sowie des Hydrochlorids der freien Säure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB730608A (en) * 1951-12-07 1955-05-25 Phrix Werke Ag Process for the preparation of -amino-ª†-ketocaproic acid
US3711458A (en) * 1969-08-21 1973-01-16 Research Corp Substituted and unsubstituted vinyloxycarbonyl groups as amino protecting groups in the syntheses of peptides
US4325877A (en) * 1980-06-16 1982-04-20 Richardson-Merrell Inc. Production of intermediates for enzyme inhibitors
US4855486A (en) * 1986-05-30 1989-08-08 Kalbag Suresh M Blocked, marked amino acids
JPH01275553A (ja) * 1988-04-26 1989-11-06 Suntory Ltd ベンジルカルバメートからｔ−ブチルカルバメートへの変換法

Also Published As

Publication number Publication date
HU903888D0 (en) 1990-11-28
FI903058A0 (fi) 1990-06-18
EP0408881A2 (de) 1991-01-23
EP0408881A3 (en) 1992-02-26
JPH0348646A (ja) 1991-03-01
DE3919898A1 (de) 1991-01-17
US5095114A (en) 1992-03-10
HUT56812A (en) 1991-10-28

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