BR9612099A - Processo para preparar um composto derivado de piperidina, regioisÈmero, processo para preparar um regioisÈmero, derivado de ácido 4-( alfa,alfa, di-substuìdo) toluico e 4- (alfa, alfa-di-não substitìdo) toluico. - Google Patents

Processo para preparar um composto derivado de piperidina, regioisÈmero, processo para preparar um regioisÈmero, derivado de ácido 4-( alfa,alfa, di-substuìdo) toluico e 4- (alfa, alfa-di-não substitìdo) toluico.

Info

Publication number
BR9612099A
BR9612099A BR9612099-1A BR9612099A BR9612099A BR 9612099 A BR9612099 A BR 9612099A BR 9612099 A BR9612099 A BR 9612099A BR 9612099 A BR9612099 A BR 9612099A
Authority
BR
Brazil
Prior art keywords
alpha
regioisomer
preparing
toluic acid
derived
Prior art date
Application number
BR9612099-1A
Other languages
English (en)
Inventor
Thomas E D Ambra
Garry M Pilling
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of BR9612099A publication Critical patent/BR9612099A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"PROCESSO PARA PREPARAR UM COMPOSTO DERIVADO DE PIPERIDINA, REGIOISÈMERO, PROCESSO PARA PREPARA UM REGIOISÈMERO, DERIVADO DE áCIDO 4-(<244>, <244>- DI-SUBSTITUìDO) TOLUICO E 4-(<244>, <244>- DI-NãO SUBSTITUìDO)TOLUICO". A presente invenção descreve o processo para preparar os compostos de derivado piperdina da fórmula (I) ou (II): em que n é 0 ou 1; R^ 1^ é hidrogênio ou hidroxi, R^ 2^ é hidrogênio; ou, quando n é 0, R^ 1^ e R^ 2^ tomados juntos formam uma segunda ligação entre os átomos de carbono contendo R^ 1^ e R^ 2^, desde que quando n é 1, R^ 1^ e R^ 2^ cada são hidrogênio; R^ 3^ é -COOH ou -COOR^ 4^, R^ 4^ é uma porção alquila ou arila; A, B, e D são os substituintes de seus anéis, cada podendo ser igual ao diferente, e são selecionados dentre o grupo consistindo de hidrogênio, halogênios, alquila, hidróxi, alcóxi, e outros substituintes. Um processo inclui prover um regioisómero da fórmula (III). em que Z é -CG^ 1^G^ 2^G^ 3^, (IV) ou (V):
BR9612099-1A 1995-12-21 1996-12-19 Processo para preparar um composto derivado de piperidina, regioisÈmero, processo para preparar um regioisÈmero, derivado de ácido 4-( alfa,alfa, di-substuìdo) toluico e 4- (alfa, alfa-di-não substitìdo) toluico. BR9612099A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/575,344 US6201124B1 (en) 1995-12-21 1995-12-21 Process for production of piperidine derivatives
PCT/US1996/020769 WO1997022344A1 (en) 1995-12-21 1996-12-19 Process for production of piperidine derivatives

Publications (1)

Publication Number Publication Date
BR9612099A true BR9612099A (pt) 1999-12-28

Family

ID=24299941

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612099-1A BR9612099A (pt) 1995-12-21 1996-12-19 Processo para preparar um composto derivado de piperidina, regioisÈmero, processo para preparar um regioisÈmero, derivado de ácido 4-( alfa,alfa, di-substuìdo) toluico e 4- (alfa, alfa-di-não substitìdo) toluico.

Country Status (16)

Country Link
US (7) US6201124B1 (pt)
EP (2) EP1362849A3 (pt)
JP (2) JP4865113B2 (pt)
KR (2) KR100516869B1 (pt)
AT (1) ATE335726T1 (pt)
AU (1) AU723759B2 (pt)
BR (1) BR9612099A (pt)
CA (1) CA2240735C (pt)
DE (1) DE69636439T2 (pt)
DK (1) DK0877733T3 (pt)
ES (1) ES2268715T3 (pt)
HU (1) HUP9900947A3 (pt)
NO (1) NO311718B1 (pt)
NZ (1) NZ326228A (pt)
PT (1) PT877733E (pt)
WO (1) WO1997022344A1 (pt)

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US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
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CN105254579A (zh) * 2015-09-19 2016-01-20 万全万特制药江苏有限公司 一种一锅法制备比拉斯汀中间体的方法
CN114621083A (zh) * 2022-03-30 2022-06-14 西安万隆制药股份有限公司 一种抗组胺药物盐酸非索非那定杂质及其合成方法和应用
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Also Published As

Publication number Publication date
NO982806D0 (no) 1998-06-18
PT877733E (pt) 2006-12-29
DE69636439D1 (de) 2006-09-21
KR20000064507A (ko) 2000-11-06
EP0877733B1 (en) 2006-08-09
HUP9900947A3 (en) 2000-12-28
KR20050086753A (ko) 2005-08-30
KR100591212B1 (ko) 2006-06-22
KR100516869B1 (ko) 2005-11-25
NZ326228A (en) 2000-02-28
ES2268715T3 (es) 2007-03-16
US7560561B2 (en) 2009-07-14
JP2009019059A (ja) 2009-01-29
AU723759B2 (en) 2000-09-07
EP1362849A2 (en) 2003-11-19
US6448406B1 (en) 2002-09-10
EP1362849A3 (en) 2003-11-26
AU1354797A (en) 1997-07-14
ATE335726T1 (de) 2006-09-15
US20100010227A1 (en) 2010-01-14
JP2000502105A (ja) 2000-02-22
US6974872B2 (en) 2005-12-13
US8022220B2 (en) 2011-09-20
US20030171590A1 (en) 2003-09-11
CA2240735C (en) 2006-08-29
NO982806L (no) 1998-08-12
US6201124B1 (en) 2001-03-13
CA2240735A1 (en) 1997-06-26
US20110295014A1 (en) 2011-12-01
JP4865113B2 (ja) 2012-02-01
DE69636439T2 (de) 2007-03-29
NO311718B1 (no) 2002-01-14
US6452011B1 (en) 2002-09-17
HUP9900947A2 (hu) 1999-07-28
WO1997022344A1 (en) 1997-06-26
EP0877733A4 (en) 1999-03-31
DK0877733T3 (da) 2006-12-11
EP0877733A1 (en) 1998-11-18
US20050272771A1 (en) 2005-12-08

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