BR9612216A - Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente. - Google Patents
Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente.Info
- Publication number
- BR9612216A BR9612216A BR9612216-1A BR9612216A BR9612216A BR 9612216 A BR9612216 A BR 9612216A BR 9612216 A BR9612216 A BR 9612216A BR 9612216 A BR9612216 A BR 9612216A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- regioisomer
- preparing
- piperidine
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"PROCESSO PARA PREPARAR UM COMPOSTO DERIVADO DE PIPERDINA, REGIOISÈMERO, PROCESSO PARA PREPARAR UM REGIOISÈMERO, DERIVADO DE <244>, <244>-DI-SUBSTITUìDO, E <244>, <244>-DI-NãO SUBSTITUìDO METILBENZENO, DERIVADO DE OXOBUTILA, PERCURSOR DE DERIVADO DE PIPERIDINA E PROCESSO PARA TRATAR REAçõES ALéRGICAS EM UM PACIENTE". A presente invenção refere-se a um processo para prepara compostos derivados de piperidina de fórmula (I, II): em que n é 0 ou 1, R^ 1^ é hidrogênio ou hidroxi, R6 2^ é hidrogênio, ou quando n é o, R^ 1^ e R^ 2^ tomados juntos formam uma segunda ligação entre os átomos de carbono contendo R^ 1^ e R^ 2^, desde que quando n é 1, R^ 1^ e R^ 2^ são cada hidrogênio, R6 3^ é -COOH, ou -COOR^ 4^, R^ 4^ é uma porção alquila ou arila, A, B, e D são os substituintes de seus anéis, cada um podendo ser diferentes ou igual, e são selecionados dentre o grupo consistindo de hidrogênio, halogênios, alquila, hidroxi, alcóxi e outros substituintes. O processo compreende prover um regioisómero de fórmula (III): em que Z é CG^ 1^G^ 2^G^ 3^ (IV) ou (V), m é um inteiro de 1 a 6, Q e Y são iguais ou diferentes e são selecionados dentre o grupo consistindo de O, S e NR^ 5^, G^ 1^, G^ 2^ e G^ 3^ são iguais ou diferentes e são selecionados dentre o gripo consistindo de OR^ 8^, SR^ 8^, e NR^ 8^R^ 9^; R^ 6^ e R6 7^ são iguais ou diferentes e são selecionados dentre o grupo consistindo de hidrogênio, uma porção alquila, uma porção arila, OR^ 8^, SR^ 5^, R^ 8^ e R^ 9& são iguais ou diferentes e são selecionados dentre o grupo consistindo de hidrogêniom, uma porção alquila, e uma porção arila e convertendo o regioisómero para o compostos derivado de piperidina com um composto piperidina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/576,068 US6153754A (en) | 1995-12-21 | 1995-12-21 | Process for production of piperidine derivatives |
PCT/US1996/020189 WO1997023213A1 (en) | 1995-12-21 | 1996-12-19 | Process for production of piperidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9612216A true BR9612216A (pt) | 1999-12-28 |
Family
ID=24302845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9612216-1A BR9612216A (pt) | 1995-12-21 | 1996-12-19 | Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente. |
Country Status (15)
Country | Link |
---|---|
US (7) | US6153754A (pt) |
EP (1) | EP0868182B1 (pt) |
JP (2) | JP4865114B2 (pt) |
KR (2) | KR100516868B1 (pt) |
AT (1) | ATE248595T1 (pt) |
AU (1) | AU723231B2 (pt) |
BR (1) | BR9612216A (pt) |
CA (1) | CA2240927C (pt) |
DE (1) | DE69629831T2 (pt) |
DK (1) | DK0868182T3 (pt) |
ES (1) | ES2206618T3 (pt) |
NO (1) | NO311717B1 (pt) |
NZ (1) | NZ326085A (pt) |
PT (1) | PT868182E (pt) |
WO (1) | WO1997023213A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100333790B1 (ko) * | 1993-06-25 | 2002-11-04 | 메렐 파마슈티칼스 인크. | 항히스타민성4-디페닐메틸/디페닐메톡시피페리딘유도체제조용신규중간체 |
US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
ES2151442B1 (es) * | 1999-01-11 | 2001-07-01 | Espanola Prod Quimicos | Nuevo derivado del bencenoetanol. |
AU2002255593A1 (en) * | 2001-02-22 | 2002-09-12 | Classen Immunotherapies, Inc. | Improved algorithms and methods for products safety |
EP1392303A4 (en) * | 2001-04-09 | 2005-01-26 | Teva Pharma | FEXOFENADINE HYDROCHLORIDE POLYMORPHS |
US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
ITRM20010260A1 (it) * | 2001-05-17 | 2002-11-18 | Dinamite Dipharma S P A In For | Processo per la preparazione della fexofenadina o acido 4 1-idrossi-4-4- (idrossidifenilmetil)-1-piperidinil|-butil|-alfa,alfa-dimetilbenz |
US7700779B2 (en) * | 2001-06-18 | 2010-04-20 | Dr. Reddy's Laboratories Limited | Crystalline forms of fexofenadine and its hydrochloride |
JP2005507374A (ja) * | 2001-06-18 | 2005-03-17 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 新規な型の4−[4−[4−(ヒドロキシジフェニルメチル)−1−ピペリジニル]−1−ヒドロキシブチル]−α,α−ジメチルベンゼン酢酸及びその塩酸塩 |
TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
JP2005532356A (ja) * | 2002-06-10 | 2005-10-27 | テバ ファーマシューティカル インダストリーズ リミティド | 塩酸フェキソフェナジンの多型体xvi |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
MXPA06012281A (es) * | 2004-04-26 | 2007-07-18 | Teva Pharma | Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion. |
US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
WO2006037042A1 (en) * | 2004-09-28 | 2006-04-06 | Teva Pharmaceutical Industries Ltd. | Fexofenadine crystal form and processes for its preparation thereof |
ZA200804550B (en) | 2005-11-09 | 2009-08-26 | Combinatorx Inc | Methods, compositions, and kits for the treatment of medical conditions |
ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
ITMI20070987A1 (it) | 2007-05-16 | 2008-11-17 | Dipharma Francis Srl | Procedimento per la preparazione di composti chetonici |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
EP2289867A3 (en) | 2009-08-19 | 2012-04-25 | Jubilant Organosys Limited | A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof |
US20110130711A1 (en) * | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
SG10201804437WA (en) | 2013-08-14 | 2018-06-28 | Mitral Valve Tech Sarl | Replacement heart valve apparatus and methods |
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FR2636946B1 (fr) * | 1988-09-23 | 1990-11-02 | Lipha | ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant |
DE4034218A1 (de) | 1990-10-27 | 1992-04-30 | Merck Patent Gmbh | Verfahren zur herstellung von carebastin |
HU211019B (en) * | 1991-12-02 | 1995-09-28 | Richter Gedeon Vegyeszet | Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds |
EP0635004B1 (en) * | 1992-04-10 | 2002-07-17 | Merrell Pharmaceuticals Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
ATE363283T1 (de) * | 1992-08-03 | 2007-06-15 | Sepracor Inc | Terfenadin-carboxylat und die behandlung von hautreizung |
US20020007068A1 (en) | 1999-07-16 | 2002-01-17 | D'ambra Thomas E. | Piperidine derivatives and process for their production |
ATE254594T1 (de) * | 1993-06-24 | 2003-12-15 | Albany Molecular Res Inc | Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate |
KR100333790B1 (ko) * | 1993-06-25 | 2002-11-04 | 메렐 파마슈티칼스 인크. | 항히스타민성4-디페닐메틸/디페닐메톡시피페리딘유도체제조용신규중간체 |
DE69632548T2 (de) | 1995-12-21 | 2005-06-02 | Bristol-Myers Squibb Pharma Co. | ISOXAZOLIN, ISOTHIAZOLIN UND PYRAZOLIN ALS FAKTOR Xa INHIBITOREN |
US6153754A (en) | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US5925761A (en) * | 1997-02-04 | 1999-07-20 | Sepracor Inc. | Synthesis of terfenadine and derivatives |
US7498345B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
-
1995
- 1995-12-21 US US08/576,068 patent/US6153754A/en not_active Expired - Lifetime
-
1996
- 1996-12-19 WO PCT/US1996/020189 patent/WO1997023213A1/en not_active Application Discontinuation
- 1996-12-19 KR KR10-1998-0704759A patent/KR100516868B1/ko not_active IP Right Cessation
- 1996-12-19 BR BR9612216-1A patent/BR9612216A/pt not_active Application Discontinuation
- 1996-12-19 CA CA002240927A patent/CA2240927C/en not_active Expired - Lifetime
- 1996-12-19 DE DE69629831T patent/DE69629831T2/de not_active Expired - Lifetime
- 1996-12-19 KR KR1020057009028A patent/KR100573943B1/ko not_active IP Right Cessation
- 1996-12-19 AU AU13371/97A patent/AU723231B2/en not_active Expired
- 1996-12-19 ES ES96944868T patent/ES2206618T3/es not_active Expired - Lifetime
- 1996-12-19 EP EP96944868A patent/EP0868182B1/en not_active Expired - Lifetime
- 1996-12-19 JP JP52379097A patent/JP4865114B2/ja not_active Expired - Lifetime
- 1996-12-19 PT PT96944868T patent/PT868182E/pt unknown
- 1996-12-19 AT AT96944868T patent/ATE248595T1/de active
- 1996-12-19 DK DK96944868T patent/DK0868182T3/da active
- 1996-12-19 NZ NZ326085A patent/NZ326085A/en not_active IP Right Cessation
-
1998
- 1998-06-16 NO NO19982770A patent/NO311717B1/no not_active IP Right Cessation
-
2000
- 2000-08-09 US US09/634,983 patent/US6444824B1/en not_active Expired - Lifetime
- 2000-08-09 US US09/637,127 patent/US6458958B1/en not_active Expired - Lifetime
-
2002
- 2002-08-05 US US10/212,829 patent/US6919458B2/en not_active Expired - Fee Related
-
2005
- 2005-05-06 US US11/123,511 patent/US20050209279A1/en not_active Abandoned
-
2006
- 2006-09-15 US US11/521,820 patent/US7678915B2/en not_active Expired - Fee Related
-
2008
- 2008-09-04 JP JP2008227504A patent/JP2009019058A/ja active Pending
-
2010
- 2010-01-13 US US12/686,516 patent/US8476445B2/en not_active Expired - Fee Related
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