BR9612216A - Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente. - Google Patents

Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente.

Info

Publication number
BR9612216A
BR9612216A BR9612216-1A BR9612216A BR9612216A BR 9612216 A BR9612216 A BR 9612216A BR 9612216 A BR9612216 A BR 9612216A BR 9612216 A BR9612216 A BR 9612216A
Authority
BR
Brazil
Prior art keywords
alpha
regioisomer
preparing
piperidine
derivative
Prior art date
Application number
BR9612216-1A
Other languages
English (en)
Inventor
Garry M Pilling
Thomas E D Ambra
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of BR9612216A publication Critical patent/BR9612216A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAR UM COMPOSTO DERIVADO DE PIPERDINA, REGIOISÈMERO, PROCESSO PARA PREPARAR UM REGIOISÈMERO, DERIVADO DE <244>, <244>-DI-SUBSTITUìDO, E <244>, <244>-DI-NãO SUBSTITUìDO METILBENZENO, DERIVADO DE OXOBUTILA, PERCURSOR DE DERIVADO DE PIPERIDINA E PROCESSO PARA TRATAR REAçõES ALéRGICAS EM UM PACIENTE". A presente invenção refere-se a um processo para prepara compostos derivados de piperidina de fórmula (I, II): em que n é 0 ou 1, R^ 1^ é hidrogênio ou hidroxi, R6 2^ é hidrogênio, ou quando n é o, R^ 1^ e R^ 2^ tomados juntos formam uma segunda ligação entre os átomos de carbono contendo R^ 1^ e R^ 2^, desde que quando n é 1, R^ 1^ e R^ 2^ são cada hidrogênio, R6 3^ é -COOH, ou -COOR^ 4^, R^ 4^ é uma porção alquila ou arila, A, B, e D são os substituintes de seus anéis, cada um podendo ser diferentes ou igual, e são selecionados dentre o grupo consistindo de hidrogênio, halogênios, alquila, hidroxi, alcóxi e outros substituintes. O processo compreende prover um regioisómero de fórmula (III): em que Z é CG^ 1^G^ 2^G^ 3^ (IV) ou (V), m é um inteiro de 1 a 6, Q e Y são iguais ou diferentes e são selecionados dentre o grupo consistindo de O, S e NR^ 5^, G^ 1^, G^ 2^ e G^ 3^ são iguais ou diferentes e são selecionados dentre o gripo consistindo de OR^ 8^, SR^ 8^, e NR^ 8^R^ 9^; R^ 6^ e R6 7^ são iguais ou diferentes e são selecionados dentre o grupo consistindo de hidrogênio, uma porção alquila, uma porção arila, OR^ 8^, SR^ 5^, R^ 8^ e R^ 9& são iguais ou diferentes e são selecionados dentre o grupo consistindo de hidrogêniom, uma porção alquila, e uma porção arila e convertendo o regioisómero para o compostos derivado de piperidina com um composto piperidina.
BR9612216-1A 1995-12-21 1996-12-19 Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente. BR9612216A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/576,068 US6153754A (en) 1995-12-21 1995-12-21 Process for production of piperidine derivatives
PCT/US1996/020189 WO1997023213A1 (en) 1995-12-21 1996-12-19 Process for production of piperidine derivatives

Publications (1)

Publication Number Publication Date
BR9612216A true BR9612216A (pt) 1999-12-28

Family

ID=24302845

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612216-1A BR9612216A (pt) 1995-12-21 1996-12-19 Processo para preparar um composto derivado de piperidina, regioisómero, processo para preparar um regioisómero, derivado de alfa, alfa- di-substituído, e alfa,alfa-di não substituído metilbenzeno, derivado de oxobutila, precursor de derivado de piperidina e processo para tratar reações alérgicas em um paciente.

Country Status (15)

Country Link
US (7) US6153754A (pt)
EP (1) EP0868182B1 (pt)
JP (2) JP4865114B2 (pt)
KR (2) KR100573943B1 (pt)
AT (1) ATE248595T1 (pt)
AU (1) AU723231B2 (pt)
BR (1) BR9612216A (pt)
CA (1) CA2240927C (pt)
DE (1) DE69629831T2 (pt)
DK (1) DK0868182T3 (pt)
ES (1) ES2206618T3 (pt)
NO (1) NO311717B1 (pt)
NZ (1) NZ326085A (pt)
PT (1) PT868182E (pt)
WO (1) WO1997023213A1 (pt)

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Also Published As

Publication number Publication date
CA2240927C (en) 2006-08-22
US6919458B2 (en) 2005-07-19
ES2206618T3 (es) 2004-05-16
KR100573943B1 (ko) 2006-04-26
JP2009019058A (ja) 2009-01-29
KR19990076650A (ko) 1999-10-15
US6458958B1 (en) 2002-10-01
US7678915B2 (en) 2010-03-16
ATE248595T1 (de) 2003-09-15
CA2240927A1 (en) 1997-07-03
AU1337197A (en) 1997-07-17
US6153754A (en) 2000-11-28
US8476445B2 (en) 2013-07-02
WO1997023213A1 (en) 1997-07-03
NO982770D0 (no) 1998-06-16
PT868182E (pt) 2004-02-27
JP2000502348A (ja) 2000-02-29
JP4865114B2 (ja) 2012-02-01
US6444824B1 (en) 2002-09-03
US20050209279A1 (en) 2005-09-22
US20070010677A1 (en) 2007-01-11
DK0868182T3 (da) 2003-12-15
NO982770L (no) 1998-06-16
US20030028029A1 (en) 2003-02-06
KR100516868B1 (ko) 2005-11-25
EP0868182B1 (en) 2003-09-03
DE69629831T2 (de) 2004-07-15
EP0868182A4 (en) 1999-04-07
EP0868182A1 (en) 1998-10-07
DE69629831D1 (de) 2003-10-09
US20100137605A1 (en) 2010-06-03
AU723231B2 (en) 2000-08-24
NZ326085A (en) 2001-04-27
NO311717B1 (no) 2002-01-14
KR20050052550A (ko) 2005-06-02

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