KR830007639A - 락탐 화합물의 제조방법 - Google Patents
락탐 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830007639A KR830007639A KR1019810005060A KR810005060A KR830007639A KR 830007639 A KR830007639 A KR 830007639A KR 1019810005060 A KR1019810005060 A KR 1019810005060A KR 810005060 A KR810005060 A KR 810005060A KR 830007639 A KR830007639 A KR 830007639A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- general formula
- solvent
- formula
- following general
- Prior art date
Links
- -1 lactam compound Chemical class 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000002904 solvent Substances 0.000 claims 7
- 239000002253 acid Chemical class 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 238000009835 boiling Methods 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 150000007530 organic bases Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Inorganic materials [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 2
- 239000000375 suspending agent Substances 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 238000006798 ring closing metathesis reaction Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 210000003708 urethra Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- a) 다음 일반식(Ⅱ) 화합물을 다음 일반식(Ⅲ) 화합물과 용매 또는 현탁화제 존재하에, 임의로 요드화 나트륨 또는 요드화 칼륨을 첨가하고, 바람직하기는 사용된 용매의 비점에서 반응시키거나,b) 다음 일반식(Ⅳ) 화합물 또는 이의 산염을 중성의 용매 존재하에, 바람직하기는 산결합제 존재하에 0-설포벤조산 디클로라이드 또는 디브로마이드 또는 0-설포벤조산 무수물과 반응시키거나,c) 일반식(Ⅳ) 화합물 또는 이의 산염을 다음 일반식(Ⅴ)의 화합물과 중성의 용매 존재하에, 바람직하기는 유기염기 존재하에 0℃에서 반응시킨후 수득된 다음 일반식(Ⅵ) 화합물을 용매로서 작용하는 탄소수 1 내지 5의 지방족 카복실산 존재하에 산화제, 바람직하기는 퍼옥시 화합물을 첨가하여 산화시키거나,d) 다음 일반식(Ⅶ) 화합물 또는 이의 작용성 유도체를 높은 온도 및 / 또는 산성 축합제존재하에 폐환시키거나,e) 다음 일반식(Ⅷ) 화합물을 임의로 중성의 용매 존재하에, Y가 클로로, 브로모 또는 요드인 경우 유기 또는 무기염기 존재하에, Y가 하이드록시인 경우 산성 탈수제 존재하에 및 / 또는 높은 온도에서, 바람직하기는 고비점 용매 또는 현탁화제 존재하에 폐환시킴을 특징으로 하는 일반식(I)의 락탐 화합물을 제조하는 방법.상기 일반식에서X는 탄소수 1 내지 4의 직쇄 또는 측쇄 알킬기이고,Hal은 요드원자 또는 바람직하기는 염소 또는 브롬원자이고,일반식(Ⅴ)에서Hal 및 Hal1는 같거나 다르며 각기 브롬 또는 요드원자 또는 바람직하기는 염소원자이고,Me는 알카리금속, 바람직하기는 나트륨 또는 칼륨이고,Y는 클로로, 브로모, 요도 또는 하이드록시기이다.
- 제1항의 (a) 또는 (b) 방법에 있어서, 광학적으로 활성인 형태의 일반식(Ⅱ) 또는 (Ⅳ) 화합물을 각기 출발물질로 사용하여 광학적으로 활성인 형태의 일반식 (I) 화합물을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3048663.6 | 1980-12-23 | ||
| DE19803048663 DE3048663A1 (de) | 1980-12-23 | 1980-12-23 | Neue lactamverbindungen, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830007639A true KR830007639A (ko) | 1983-11-04 |
Family
ID=6120078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810005060A KR830007639A (ko) | 1980-12-23 | 1981-12-22 | 락탐 화합물의 제조방법 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4399145A (ko) |
| EP (1) | EP0054672A1 (ko) |
| JP (1) | JPS57123178A (ko) |
| KR (1) | KR830007639A (ko) |
| AU (1) | AU7730281A (ko) |
| DE (1) | DE3048663A1 (ko) |
| DK (1) | DK567181A (ko) |
| ES (2) | ES8302702A1 (ko) |
| FI (1) | FI814067L (ko) |
| GR (1) | GR75377B (ko) |
| IL (1) | IL64043A0 (ko) |
| NO (1) | NO813693L (ko) |
| PT (1) | PT73949B (ko) |
| YU (1) | YU306781A (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335289C (en) * | 1987-10-26 | 1995-04-18 | Fujio Antoku | Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use |
| DE4422237A1 (de) | 1994-06-24 | 1996-01-04 | Gruenenthal Gmbh | Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe |
| EP1204151A4 (en) | 2000-04-24 | 2006-10-18 | Rohm Co Ltd | SIDE-EMITTING LUMINAIRE DIODE AND MANUFACTURING METHOD |
| US6680331B2 (en) * | 2001-07-16 | 2004-01-20 | Board Of Regents, The University Of Texas System | Lactam and thiolactam derivatives as anesthetic and conscious sedation agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR205791A1 (es) * | 1972-03-03 | 1976-06-07 | Gruenenthal Chemie | Procedimiento de preparacion de sulfobenzo lactamas |
-
1980
- 1980-12-23 DE DE19803048663 patent/DE3048663A1/de not_active Withdrawn
-
1981
- 1981-10-08 GR GR66235A patent/GR75377B/el unknown
- 1981-10-12 IL IL64043A patent/IL64043A0/xx unknown
- 1981-10-22 EP EP81108664A patent/EP0054672A1/de not_active Ceased
- 1981-11-02 NO NO813693A patent/NO813693L/no unknown
- 1981-11-02 ES ES506792A patent/ES8302702A1/es not_active Expired
- 1981-11-05 US US06/318,389 patent/US4399145A/en not_active Expired - Fee Related
- 1981-11-09 AU AU77302/81A patent/AU7730281A/en not_active Abandoned
- 1981-11-09 PT PT73949A patent/PT73949B/pt unknown
- 1981-12-01 JP JP56191879A patent/JPS57123178A/ja active Pending
- 1981-12-17 FI FI814067A patent/FI814067L/fi not_active Application Discontinuation
- 1981-12-21 DK DK567181A patent/DK567181A/da not_active Application Discontinuation
- 1981-12-22 KR KR1019810005060A patent/KR830007639A/ko unknown
- 1981-12-23 YU YU03067/81A patent/YU306781A/xx unknown
-
1982
- 1982-10-16 ES ES516597A patent/ES8307246A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK567181A (da) | 1982-06-24 |
| YU306781A (en) | 1984-04-30 |
| ES506792A0 (es) | 1983-02-01 |
| GR75377B (ko) | 1984-07-13 |
| EP0054672A1 (de) | 1982-06-30 |
| ES516597A0 (es) | 1983-06-16 |
| JPS57123178A (en) | 1982-07-31 |
| US4399145A (en) | 1983-08-16 |
| PT73949B (de) | 1983-04-18 |
| ES8302702A1 (es) | 1983-02-01 |
| DE3048663A1 (de) | 1982-07-22 |
| AU7730281A (en) | 1982-07-01 |
| FI814067L (fi) | 1982-06-24 |
| IL64043A0 (en) | 1982-01-31 |
| NO813693L (no) | 1982-06-24 |
| ES8307246A1 (es) | 1983-06-16 |
| PT73949A (de) | 1981-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR880000433A (ko) | 이미다조피리딘 및 중간체 화합물의 제조방법 | |
| KR910000657A (ko) | 옥사-또는 티아-졸린 유도체 | |
| KR870003989A (ko) | 치환 및 이치환 피리딘-2,3-디카르복실레이트의 제조방법과 치환된 니코티네이트의 제조방법 | |
| KR830005148A (ko) | 항 알러지성 이미도디설파마이드의 제조방법 | |
| KR840000463A (ko) | 광학적으로 활성인 1-방향족 그룹으로 치환된-1- 알카논의 제조방법 | |
| KR830007639A (ko) | 락탐 화합물의 제조방법 | |
| ATE53034T1 (de) | Verfahren zur herstellung von cephemverbindungen. | |
| KR830007554A (ko) | 인돌리논의 제조방법 | |
| KR870007127A (ko) | 퀴놀론 카복실산 유도체의 제조방법 | |
| KR840006487A (ko) | 세팔로스포린의 제조방법 | |
| KR880009937A (ko) | 치환된 3-알킬퀴놀린-8-카르복실산의 제조방법 | |
| KR830001948A (ko) | 페니실린 설폭사이드의 제조방법 | |
| KR830010083A (ko) | 치환된 아세트 아닐리드 유도체의 제조방법 | |
| KR830007647A (ko) | 벤조헤테로사이클릭 화합물의 제조방법 | |
| KR830006180A (ko) | 뱃트물감제조용 신규중간물 α-벤즈아미도-5'(또는 8')-할로게노-1, 1'-디안트 리미드류 등의 α-벤즈아미도 -α'-할로게노-1, 1'-디안트리미드류의 제조방법 | |
| KR860009011A (ko) | 치환된 이속사졸 유도체의 제조방법 | |
| KR850007425A (ko) | 세팔로스포린 유도체와 이의 염의 제조방법 | |
| ES8703401A1 (es) | Procedimiento para la obtencion de esteres del acido 4-aci- loxi-3-oxo-butirico | |
| KR840006478A (ko) | 벤조 트리아졸의 제조방법 | |
| KR850006397A (ko) | 치환된 이소크로만 및 옥세핀의 제조방법 | |
| KR910011845A (ko) | 2-푸릴피리미딘 유도체의 제조방법 | |
| KR830003458A (ko) | 2-티옥소-3-벤조치아졸린 아세토니트릴의 유도체 | |
| KR860008965A (ko) | 1,3-프로판디온 유도체를 제조하는 방법 | |
| KR840000480A (ko) | 페녹시 벤조산류에서 유도된 제초제 화합물류의 제조방법 | |
| KR830005175A (ko) | 치환된 트리아릴티아졸 화합물의 제조방법 |