KR840004436A - 페니실린 유도체의 제조방법 - Google Patents
페니실린 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840004436A KR840004436A KR1019830001723A KR830001723A KR840004436A KR 840004436 A KR840004436 A KR 840004436A KR 1019830001723 A KR1019830001723 A KR 1019830001723A KR 830001723 A KR830001723 A KR 830001723A KR 840004436 A KR840004436 A KR 840004436A
- Authority
- KR
- South Korea
- Prior art keywords
- reaction
- oxidation
- prepared
- derivative
- salt
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 하기식의 페니실린유도체와 제약에 쓸수있는 그 유도체의 염, 그리고 그 유도체의 에스터 제조방법.상기식에서 n 은 0,1 또는 2이고 하기식 화합물의 반응단계로 구성되어 있다.상기식에서 X 는 염소 또는 브롬원자이고,R은 제약에 쓸수있는 에스터잔류물이다. n은 상기에 표시하였고, 상기 화합물은 금속아자이드와, 그리고 필요할때 산화, 탈-에스터화, 에스터교환, 그리고 염-형성반응중 어느 한 반응을 통해 진행된다.
- 제1항에 있어서, 하기식 화합물을 특징으로 하는 제조방법.상기식에서 R은 이미 정의하였고, 금속아이드자와 반응이 완결된 후 산화되지 않고 제조되었다.
- 제1항에 있어서, 하기식 화합물을 특징으로 하는 제조방법상기에서 R은 이미 정의하였고, 금속 아자이드와 반응이 완결된 후 산화시켜 제조되었다.
- 제1항에 있어서, 하기식 화합물을 특징으로 하는 제조방법.상기에서 n은 0,1 또는 2이고, 금속아자이드와 반응이 종결된 후, 산화되거나 또는 산화되지 않고 탈-에스터화시켜 제조되었다.
- 제1항에 있어서, 페니실린 유도체의 염은 금속아자이드와 반응이 종결된 후, 산화되거나 또는 산화되지 않고 효과적인 염-형성반응에 의해 제조되는 것을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57069142A JPS58185589A (ja) | 1982-04-23 | 1982-04-23 | ペニシリン誘導体 |
JP69142/82 | 1982-04-23 | ||
JP69142 | 1987-03-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR840004436A true KR840004436A (ko) | 1984-10-15 |
KR900005046B1 KR900005046B1 (ko) | 1990-07-18 |
Family
ID=13394097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830001723A KR900005046B1 (ko) | 1982-04-23 | 1983-04-23 | 페니실린 유도체의 제조방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4507239A (ko) |
EP (1) | EP0092948B1 (ko) |
JP (1) | JPS58185589A (ko) |
KR (1) | KR900005046B1 (ko) |
AU (1) | AU538789B2 (ko) |
CA (1) | CA1197840A (ko) |
DE (1) | DE3369850D1 (ko) |
ES (1) | ES8502118A1 (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1239392A (en) * | 1983-10-13 | 1988-07-19 | Shigeru Yamabe | Penicillin derivatives and process for preparing the same |
JPS62249988A (ja) * | 1986-04-22 | 1987-10-30 | Taiho Yakuhin Kogyo Kk | 2β−ハロゲノメチル−2α−メチルペナム−3α−カルボン酸誘導体の製造法 |
JP2603082B2 (ja) * | 1987-09-07 | 1997-04-23 | 大塚化学株式会社 | ペニシラン酸誘導体の製造法 |
TW200523264A (en) | 2003-10-09 | 2005-07-16 | Otsuka Chemical Co Ltd | CMPB crystal and method for producing the same |
JP4716708B2 (ja) * | 2004-10-28 | 2011-07-06 | 大塚化学株式会社 | ペナム化合物の製造方法 |
CN102503956A (zh) * | 2011-11-21 | 2012-06-20 | 江西华邦药业有限公司 | 青霉烷二苯甲酯亚砜的制备方法 |
CN103497203B (zh) * | 2013-10-16 | 2015-09-30 | 齐鲁天和惠世制药有限公司 | 一种2β-叠氮甲基-2α-甲基青霉烷-3α-羧酸二苯甲酯的合成方法 |
CN108997375A (zh) * | 2018-08-10 | 2018-12-14 | 潍坊奥通药业有限公司 | 一种6,6-二氢青霉烷酸二苯甲酯-s-亚砜的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4218374A (en) * | 1972-10-20 | 1980-08-19 | Fujisawa Pharmaceutical Company, Limited | Penam derivatives |
US4234579A (en) * | 1977-06-07 | 1980-11-18 | Pfizer Inc. | Penicillanic acid 1,1-dioxides as β-lactamase inhibitors |
US4256733A (en) * | 1979-09-26 | 1981-03-17 | Pfizer Inc. | Acetoxymethyl penam compounds as β-lactamase inhibitors |
FI67553C (fi) * | 1980-01-21 | 1985-04-10 | Bristol Myers Co | Foerfarande foer framstaellning av en terapeutiskt anvaendbar 2beta-klormetyl-2alfa-metylpenam-3alfa-karboxylsyrasulfon sater och estrar daerav |
-
1982
- 1982-04-23 JP JP57069142A patent/JPS58185589A/ja active Granted
-
1983
- 1983-04-14 AU AU13527/83A patent/AU538789B2/en not_active Ceased
- 1983-04-15 EP EP83302160A patent/EP0092948B1/en not_active Expired
- 1983-04-15 DE DE8383302160T patent/DE3369850D1/de not_active Expired
- 1983-04-21 ES ES521941A patent/ES8502118A1/es not_active Expired
- 1983-04-22 CA CA000426531A patent/CA1197840A/en not_active Expired
- 1983-04-23 KR KR1019830001723A patent/KR900005046B1/ko not_active IP Right Cessation
- 1983-06-22 US US06/487,558 patent/US4507239A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0092948A2 (en) | 1983-11-02 |
CA1197840A (en) | 1985-12-10 |
AU538789B2 (en) | 1984-08-30 |
DE3369850D1 (en) | 1987-04-02 |
EP0092948B1 (en) | 1987-02-25 |
US4507239A (en) | 1985-03-26 |
KR900005046B1 (ko) | 1990-07-18 |
JPS58185589A (ja) | 1983-10-29 |
ES521941A0 (es) | 1985-01-01 |
AU1352783A (en) | 1983-10-27 |
ES8502118A1 (es) | 1985-01-01 |
JPH0124154B2 (ko) | 1989-05-10 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19960716 Year of fee payment: 7 |
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LAPS | Lapse due to unpaid annual fee |