KR830007604A - 피록시캄의 제조 방법 - Google Patents

피록시캄의 제조 방법 Download PDF

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Publication number
KR830007604A
KR830007604A KR1019810003626A KR810003626A KR830007604A KR 830007604 A KR830007604 A KR 830007604A KR 1019810003626 A KR1019810003626 A KR 1019810003626A KR 810003626 A KR810003626 A KR 810003626A KR 830007604 A KR830007604 A KR 830007604A
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KR
South Korea
Prior art keywords
reaction
pyroxycam
preparing
solvent
pyoxycamps
Prior art date
Application number
KR1019810003626A
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English (en)
Other versions
KR850000923B1 (ko
Inventor
죠지 롬바르디노 조셉
Original Assignee
윌리암 데이비스 헌
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 데이비스 헌, 화이자 인코포레이티드 filed Critical 윌리암 데이비스 헌
Publication of KR830007604A publication Critical patent/KR830007604A/ko
Application granted granted Critical
Publication of KR850000923B1 publication Critical patent/KR850000923B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

피록시캄의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식으로 표시되는 에스테르와 2-아미노피리딘을 115 내지 175℃ 온도하의 반응 불활성 용매중에서 반응이 실재로 종료될 때까지 반응시킴을 특징으로 하는 피록시캄의 제조 방법.
  2. 제1항에 있어서 용매가 크실렌임을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서 2-메톡시에탄올 부산물을 반응시의 용매와 함께 공비 증류에 의해 제거함을 특징으로 하는 방법.
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019810003626A 1980-09-29 1981-09-28 피록시캄의 제조 방법 KR850000923B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US191,716 1980-09-29
US06/191,716 US4289879A (en) 1980-09-29 1980-09-29 Synthetic method and intermediate for piroxicam
US191716 1980-09-29

Publications (2)

Publication Number Publication Date
KR830007604A true KR830007604A (ko) 1983-11-04
KR850000923B1 KR850000923B1 (ko) 1985-06-28

Family

ID=22706653

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810003626A KR850000923B1 (ko) 1980-09-29 1981-09-28 피록시캄의 제조 방법

Country Status (30)

Country Link
US (1) US4289879A (ko)
EP (1) EP0049099B1 (ko)
JP (2) JPS5788172A (ko)
KR (1) KR850000923B1 (ko)
AR (1) AR228373A1 (ko)
AU (1) AU528125B2 (ko)
CA (1) CA1171413A (ko)
CS (1) CS228520B2 (ko)
DD (1) DD202151A5 (ko)
DE (1) DE3171404D1 (ko)
DK (1) DK148232C (ko)
EG (1) EG16103A (ko)
ES (1) ES8206518A1 (ko)
FI (1) FI72719C (ko)
GR (1) GR75772B (ko)
GT (1) GT198171634A (ko)
HK (1) HK52287A (ko)
HU (1) HU186785B (ko)
IE (1) IE51598B1 (ko)
IL (1) IL63938A0 (ko)
MY (1) MY8700511A (ko)
NO (1) NO158061C (ko)
NZ (1) NZ198475A (ko)
PH (1) PH18475A (ko)
PL (1) PL130042B1 (ko)
PT (1) PT73738B (ko)
SG (1) SG23187G (ko)
SU (1) SU1122224A3 (ko)
YU (1) YU42428B (ko)
ZA (1) ZA816706B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434164A (en) 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
IN158333B (ko) * 1981-08-03 1986-10-18 Pfizer
GT198276334A (es) * 1981-08-03 1984-01-10 Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
US4376204A (en) * 1981-10-05 1983-03-08 Pfizer Inc. 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam
IN159273B (ko) * 1981-10-05 1987-04-25 Pfizer
CA1197244A (en) * 1982-04-16 1985-11-26 Medichem, S.A. Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides
SU1306476A3 (ru) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
ATE31309T1 (de) * 1982-07-07 1987-12-15 Siegfried Ag Verfahren zur herstellung von 4-hydroxy-2-methyln-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid 1,1- dioxid.
IT1153293B (it) * 1982-10-22 1987-01-14 Francia Famaceutici S R L Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione
FI72317C (fi) * 1983-10-06 1987-05-11 Pfizer Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-metyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid -3-(n-2-pyridyl)-karboxamid och i foerfarandet anvaendbar mellanprodukt.
US4829062A (en) * 1986-05-16 1989-05-09 Pfizer Inc. Benzothiazine dioxide derivatives
ES2002646A6 (es) * 1987-03-27 1988-09-01 Induspol Sa Procedimiento para la obtencion de 4-hidroxi-2-metil-n-(2-piri-dil)-2h-1,2-benzotiacina-3-carboxamida 1,1-dioxido
US5081118A (en) * 1987-10-26 1992-01-14 Pfizer Inc. Benzothiazine dioxide derivatives
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501466A (en) * 1967-11-30 1970-03-17 Mcneilab Inc 3-carbamoyl and 3-alkoxycarbonyl benzothiazine-1,1-dioxides
US3591584A (en) * 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
US4074048A (en) * 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides

Also Published As

Publication number Publication date
PH18475A (en) 1985-07-18
FI72719B (fi) 1987-03-31
CS228520B2 (en) 1984-05-14
PT73738B (en) 1983-11-08
EP0049099A2 (en) 1982-04-07
SU1122224A3 (ru) 1984-10-30
DE3171404D1 (en) 1985-08-22
AU528125B2 (en) 1983-04-14
AR228373A1 (es) 1983-02-28
FI72719C (fi) 1987-07-10
NO813290L (no) 1982-03-30
HU186785B (en) 1985-09-30
FI813003L (fi) 1982-03-30
PT73738A (en) 1981-10-01
SG23187G (en) 1987-07-10
ZA816706B (en) 1982-09-29
DK148232B (da) 1985-05-13
HK52287A (en) 1987-07-17
IL63938A0 (en) 1981-12-31
AU7569881A (en) 1982-04-08
YU230981A (en) 1983-06-30
MY8700511A (en) 1987-12-31
PL130042B1 (en) 1984-07-31
DK428781A (da) 1982-03-30
YU42428B (en) 1988-08-31
KR850000923B1 (ko) 1985-06-28
IE51598B1 (en) 1987-01-21
JPS632434B2 (ko) 1988-01-19
DK148232C (da) 1985-10-21
CA1171413A (en) 1984-07-24
NO158061C (no) 1988-07-06
IE812233L (en) 1982-03-29
ES505851A0 (es) 1982-08-16
EP0049099B1 (en) 1985-07-17
NZ198475A (en) 1984-07-31
PL233212A1 (ko) 1982-08-30
JPH0315638B2 (ko) 1991-03-01
EG16103A (en) 1987-10-30
EP0049099A3 (en) 1982-09-08
NO158061B (no) 1988-03-28
DD202151A5 (de) 1983-08-31
JPS5788172A (en) 1982-06-01
JPS61112064A (ja) 1986-05-30
ES8206518A1 (es) 1982-08-16
GR75772B (ko) 1984-08-02
GT198171634A (es) 1983-03-19
US4289879A (en) 1981-09-15

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