ES8206518A1 - Un procedimiento para la conversion de un ester - Google Patents
Un procedimiento para la conversion de un esterInfo
- Publication number
- ES8206518A1 ES8206518A1 ES505851A ES505851A ES8206518A1 ES 8206518 A1 ES8206518 A1 ES 8206518A1 ES 505851 A ES505851 A ES 505851A ES 505851 A ES505851 A ES 505851A ES 8206518 A1 ES8206518 A1 ES 8206518A1
- Authority
- ES
- Spain
- Prior art keywords
- piroxicam
- synthetic method
- benzothiazine
- hydroxy
- dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002702 piroxicam Drugs 0.000 title abstract 2
- 238000010189 synthetic method Methods 0.000 title 1
- VJGMQUWZFATDFA-UHFFFAOYSA-N 2-methoxyethyl 4-hydroxy-2-methyl-1,1-dioxo-1$l^{6},2-benzothiazine-3-carboxylate Chemical compound C1=CC=C2S(=O)(=O)N(C)C(C(=O)OCCOC)=C(O)C2=C1 VJGMQUWZFATDFA-UHFFFAOYSA-N 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA TRANSFORMACION DEL ESTER 1,1-DIOXIDO DEL 4-HIDROXI-2-METIL-2H-1,2-BENZOTIAZIN-3-CARBOXILATO DE 2-METOXIETILO EN PIROXICAM. CONSISTE EN LA REACCION DE DICHO ESTER CON 2-AMINOPIRIDINA PARA FORMAR 1,1-DIOXIDO DE 4-HIDROXI-2-METIL-N-2-PIRIDIL-2H-1,2,BENZOTIAZIN-3-CARBOXAMIDA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO FUERTE, TAL COMO XILENO, A UNA TEMPERATURA ENTRE 115 Y 175C., ELIMINANDO EL SUBPRODUCTO 2-METOXIETANOL POR CODESTILACION CON EL DISOLVENTE DURANTE LA REACCION. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANTIINFLAMATORIO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/191,716 US4289879A (en) | 1980-09-29 | 1980-09-29 | Synthetic method and intermediate for piroxicam |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES505851A0 ES505851A0 (es) | 1982-08-16 |
| ES8206518A1 true ES8206518A1 (es) | 1982-08-16 |
Family
ID=22706653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES505851A Expired ES8206518A1 (es) | 1980-09-29 | 1981-09-28 | Un procedimiento para la conversion de un ester |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4289879A (es) |
| EP (1) | EP0049099B1 (es) |
| JP (2) | JPS5788172A (es) |
| KR (1) | KR850000923B1 (es) |
| AR (1) | AR228373A1 (es) |
| AU (1) | AU528125B2 (es) |
| CA (1) | CA1171413A (es) |
| CS (1) | CS228520B2 (es) |
| DD (1) | DD202151A5 (es) |
| DE (1) | DE3171404D1 (es) |
| DK (1) | DK148232C (es) |
| EG (1) | EG16103A (es) |
| ES (1) | ES8206518A1 (es) |
| FI (1) | FI72719C (es) |
| GR (1) | GR75772B (es) |
| GT (1) | GT198171634A (es) |
| HK (1) | HK52287A (es) |
| HU (1) | HU186785B (es) |
| IE (1) | IE51598B1 (es) |
| IL (1) | IL63938A0 (es) |
| MY (1) | MY8700511A (es) |
| NO (1) | NO158061C (es) |
| NZ (1) | NZ198475A (es) |
| PH (1) | PH18475A (es) |
| PL (1) | PL130042B1 (es) |
| PT (1) | PT73738B (es) |
| SG (1) | SG23187G (es) |
| SU (1) | SU1122224A3 (es) |
| YU (1) | YU42428B (es) |
| ZA (1) | ZA816706B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4434164A (en) | 1981-06-01 | 1984-02-28 | Pfizer Inc. | Crystalline benzothiazine dioxide salts |
| IN158333B (es) * | 1981-08-03 | 1986-10-18 | Pfizer | |
| GT198276334A (es) * | 1981-08-03 | 1984-01-10 | Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina. | |
| IN159273B (es) * | 1981-10-05 | 1987-04-25 | Pfizer | |
| US4376204A (en) * | 1981-10-05 | 1983-03-08 | Pfizer Inc. | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam |
| CA1197244A (en) * | 1982-04-16 | 1985-11-26 | Medichem, S.A. | Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides |
| SU1306476A3 (ru) * | 1982-06-17 | 1987-04-23 | Пфайзер,Инк (Фирма) | Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида |
| EP0098422B1 (de) * | 1982-07-07 | 1987-12-09 | Siegfried Aktiengesellschaft | Verfahren zur Herstellung von 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazin-3-carboxamid 1,1-dioxid |
| IT1153293B (it) * | 1982-10-22 | 1987-01-14 | Francia Famaceutici S R L | Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione |
| FI72317C (fi) * | 1983-10-06 | 1987-05-11 | Pfizer | Foerfarande foer framstaellning av farmaceutiskt anvaendbar 2-metyl-4-hydroxi-2h-1,2-benzotiazin-1,1-dioxid -3-(n-2-pyridyl)-karboxamid och i foerfarandet anvaendbar mellanprodukt. |
| WO1987006933A1 (en) * | 1986-05-16 | 1987-11-19 | Pfizer Inc. | Benzothiazine dioxide derivatives |
| ES2002646A6 (es) * | 1987-03-27 | 1988-09-01 | Induspol Sa | Procedimiento para la obtencion de 4-hidroxi-2-metil-n-(2-piri-dil)-2h-1,2-benzotiacina-3-carboxamida 1,1-dioxido |
| US5081118A (en) * | 1987-10-26 | 1992-01-14 | Pfizer Inc. | Benzothiazine dioxide derivatives |
| FR2942797B1 (fr) * | 2009-03-03 | 2011-04-29 | Pf Medicament | Derives de benzothiazines, leur preparation et leur application a titre de medicaments |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501466A (en) * | 1967-11-30 | 1970-03-17 | Mcneilab Inc | 3-carbamoyl and 3-alkoxycarbonyl benzothiazine-1,1-dioxides |
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3787324A (en) * | 1971-03-01 | 1974-01-22 | Warner Lambert Co | 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production |
| US3853862A (en) * | 1973-04-23 | 1974-12-10 | Pfizer | Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides |
| US4074048A (en) * | 1976-05-10 | 1978-02-14 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides |
-
1980
- 1980-09-29 US US06/191,716 patent/US4289879A/en not_active Expired - Lifetime
-
1981
- 1981-09-23 EG EG541/81A patent/EG16103A/xx active
- 1981-09-23 EP EP81304370A patent/EP0049099B1/en not_active Expired
- 1981-09-23 DE DE8181304370T patent/DE3171404D1/de not_active Expired
- 1981-09-25 CA CA000386690A patent/CA1171413A/en not_active Expired
- 1981-09-25 GT GT198171634A patent/GT198171634A/es unknown
- 1981-09-25 IE IE2233/81A patent/IE51598B1/en not_active IP Right Cessation
- 1981-09-25 IL IL63938A patent/IL63938A0/xx not_active IP Right Cessation
- 1981-09-25 YU YU2309/81A patent/YU42428B/xx unknown
- 1981-09-25 AR AR286875A patent/AR228373A1/es active
- 1981-09-28 NO NO813290A patent/NO158061C/no unknown
- 1981-09-28 HU HU812792A patent/HU186785B/hu not_active IP Right Cessation
- 1981-09-28 SU SU813338298A patent/SU1122224A3/ru active
- 1981-09-28 ES ES505851A patent/ES8206518A1/es not_active Expired
- 1981-09-28 DK DK428781A patent/DK148232C/da not_active IP Right Cessation
- 1981-09-28 PL PL1981233212A patent/PL130042B1/pl unknown
- 1981-09-28 CS CS817107A patent/CS228520B2/cs unknown
- 1981-09-28 PT PT73738A patent/PT73738B/pt not_active IP Right Cessation
- 1981-09-28 DD DD81233629A patent/DD202151A5/de not_active IP Right Cessation
- 1981-09-28 ZA ZA816706A patent/ZA816706B/xx unknown
- 1981-09-28 GR GR66142A patent/GR75772B/el unknown
- 1981-09-28 JP JP56153540A patent/JPS5788172A/ja active Granted
- 1981-09-28 FI FI813003A patent/FI72719C/fi not_active IP Right Cessation
- 1981-09-28 NZ NZ198475A patent/NZ198475A/xx unknown
- 1981-09-28 AU AU75698/81A patent/AU528125B2/en not_active Ceased
- 1981-09-28 KR KR1019810003626A patent/KR850000923B1/ko active
- 1981-09-29 PH PH26285A patent/PH18475A/en unknown
-
1985
- 1985-11-06 JP JP60248694A patent/JPS61112064A/ja active Granted
-
1987
- 1987-03-09 SG SG231/87A patent/SG23187G/en unknown
- 1987-07-09 HK HK522/87A patent/HK52287A/xx unknown
- 1987-12-30 MY MY511/87A patent/MY8700511A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970505 |