KR830002801B1 - 고(高) 콜레스테롤혈증치료제, 모나콜린 k의 제조방법 - Google Patents
고(高) 콜레스테롤혈증치료제, 모나콜린 k의 제조방법 Download PDFInfo
- Publication number
- KR830002801B1 KR830002801B1 KR1019800000654A KR800000654A KR830002801B1 KR 830002801 B1 KR830002801 B1 KR 830002801B1 KR 1019800000654 A KR1019800000654 A KR 1019800000654A KR 800000654 A KR800000654 A KR 800000654A KR 830002801 B1 KR830002801 B1 KR 830002801B1
- Authority
- KR
- South Korea
- Prior art keywords
- monacoline
- cholesterol
- days
- monacholine
- culturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YHTLGFCVBKENTE-RXMQYKEDSA-N C[C@H](CCO1)CC1=O Chemical compound C[C@H](CCO1)CC1=O YHTLGFCVBKENTE-RXMQYKEDSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54017856A JPS5925599B2 (ja) | 1979-02-20 | 1979-02-20 | 新生理活性物質モナコリンｋおよびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830002030A KR830002030A (ko) | 1983-05-21 |
| KR830002801B1 true KR830002801B1 (ko) | 1983-12-16 |
Family
ID=11955290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800000654A Expired KR830002801B1 (ko) | 1979-02-20 | 1980-02-19 | 고(高) 콜레스테롤혈증치료제, 모나콜린 k의 제조방법 |
Country Status (27)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Ｍｂ−５３０ａ誘導体 |
| JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Ｍｂ−５３０ｂ誘導体およびその製造法 |
| US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| CA2062023A1 (en) * | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
| WO1993017991A1 (en) * | 1992-03-04 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
| ZA933359B (en) | 1992-05-15 | 1993-12-08 | Sankyo Co | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use |
| HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
| US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| CZ300153B6 (cs) | 1998-03-20 | 2009-02-25 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Metabolicky kontrolovaný proces fermentace pri výrobe lovastatinové hydroxykyseliny |
| AU3654301A (en) | 2000-02-24 | 2001-09-03 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| PL357533A1 (en) | 2000-03-03 | 2004-07-26 | Plus Chemicals, S.A. | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
| KR20010095780A (ko) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | 배아 홍국 |
| IN192861B (enrdf_load_stackoverflow) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| AU2002235885A1 (en) | 2001-02-09 | 2002-08-28 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| KR20020093147A (ko) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | 성인병 예방 및 치료 보조제 |
| KR100710500B1 (ko) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 ｋ 생산방법 |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| RO128803A0 (ro) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Compoziţie pentru tratamentul sau prevenirea dislipidemiilor |
| CN111297938A (zh) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | 一种辅助降血脂组合物中洛伐他汀的检测方法 |
| JP2022135089A (ja) * | 2021-03-04 | 2022-09-15 | 小林製薬株式会社 | コレステロールの低減剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (enrdf_load_stackoverflow) | 1974-06-07 | 1981-03-18 | ||
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/ja not_active Expired
-
1980
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/ko not_active Expired
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-20 DD DD80219159A patent/DD154494A5/de unknown
- 1980-02-20 DK DK73080A patent/DK149095C/da not_active IP Right Cessation
- 1980-02-20 NL NL8001041A patent/NL191540C/xx not_active IP Right Cessation
- 1980-02-20 NO NO800451A patent/NO153974C/no unknown
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 HU HU80397A patent/HU182069B/hu unknown
- 1980-02-20 BE BE0/199476A patent/BE881825A/fr not_active IP Right Cessation
- 1980-02-20 ES ES488796A patent/ES8103171A1/es not_active Expired
- 1980-02-20 SE SE8001339A patent/SE453301B/sv not_active IP Right Cessation
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 AT AT0092980A patent/AT373915B/de not_active IP Right Cessation
- 1980-02-20 CH CH136680A patent/CH645890A5/de not_active IP Right Cessation
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/xx unknown
- 1980-02-20 PL PL1980222120A patent/PL124304B1/pl unknown
- 1980-02-20 SU SU802887300A patent/SU1158048A3/ru active
- 1980-02-20 FR FR8003662A patent/FR2449685B1/fr not_active Expired
- 1980-02-20 IT IT67262/80A patent/IT1175260B/it active
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 DE DE3006216A patent/DE3006216C2/de not_active Expired
- 1980-02-20 FI FI800506A patent/FI66427C/fi not_active IP Right Cessation
- 1980-02-20 MX MX808652U patent/MX6314E/es unknown
- 1980-09-12 SU SU802977031A patent/SU969702A1/ru active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889D0/da not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
Also Published As
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| DK165990B (da) | Fremgangsmaade til fremstilling af carboxylsyren af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k eller salte deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19800219 |
|
| PG1501 | Laying open of application | ||
| PG1605 | Publication of application before grant of patent |
Comment text: Decision on Publication of Application Patent event code: PG16051S01I |
|
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19840227 |
|
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 19840522 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 19840522 End annual number: 3 Start annual number: 1 |
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| PR1001 | Payment of annual fee |
Payment date: 19861114 Start annual number: 4 End annual number: 4 |
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| PR1001 | Payment of annual fee |
Payment date: 19871123 Start annual number: 5 End annual number: 5 |
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| PR1001 | Payment of annual fee |
Payment date: 19880210 Start annual number: 6 End annual number: 6 |
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| PR1001 | Payment of annual fee |
Payment date: 19891120 Start annual number: 7 End annual number: 7 |
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| PR1001 | Payment of annual fee |
Payment date: 19901105 Start annual number: 8 End annual number: 8 |
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| PR1001 | Payment of annual fee |
Payment date: 19911127 Start annual number: 9 End annual number: 9 |
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| PR1001 | Payment of annual fee |
Payment date: 19921127 Start annual number: 10 End annual number: 10 |
|
| PR1001 | Payment of annual fee |
Payment date: 19931112 Start annual number: 11 End annual number: 11 |
|
| PR1001 | Payment of annual fee |
Payment date: 19941108 Start annual number: 12 End annual number: 12 |
|
| PC1801 | Expiration of term |