KR20230056796A - 지방산 및 생체분자에 대한 접합에서의 이의 용도 - Google Patents

지방산 및 생체분자에 대한 접합에서의 이의 용도 Download PDF

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Publication number
KR20230056796A
KR20230056796A KR1020237013073A KR20237013073A KR20230056796A KR 20230056796 A KR20230056796 A KR 20230056796A KR 1020237013073 A KR1020237013073 A KR 1020237013073A KR 20237013073 A KR20237013073 A KR 20237013073A KR 20230056796 A KR20230056796 A KR 20230056796A
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South Korea
Prior art keywords
peptide
conjugate
gdf15
acid
disease
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Ceased
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KR1020237013073A
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Korean (ko)
Inventor
데이비드 웨닝거 바네스
켄 야마다
치퀜두 이베분조
치??두 이베분조
알로케시 두타로이
루이스 클레어 커만
알렉산드라 마르쉘 브루스
에이미 리차드슨 우세라
프레데릭 제크리
준 유안
창강 로우
아아론 칸터
아비루프 보스
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노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20230056796A publication Critical patent/KR20230056796A/ko
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    • AHUMAN NECESSITIES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/095Oxytocins; Vasopressins; Related peptides
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    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
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    • A61K38/1841Transforming growth factor [TGF]
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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KR1020237013073A 2014-06-23 2015-06-18 지방산 및 생체분자에 대한 접합에서의 이의 용도 Ceased KR20230056796A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US62/015,862 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US62/082,327 2014-11-20
US201562107016P 2015-01-23 2015-01-23
US62/107,016 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules
KR1020177001520A KR102559975B1 (ko) 2014-06-23 2015-06-18 지방산 및 생체분자에 대한 접합에서의 이의 용도

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KR1020177001520A Active KR102559975B1 (ko) 2014-06-23 2015-06-18 지방산 및 생체분자에 대한 접합에서의 이의 용도

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US (4) US10588980B2 (enExample)
EP (2) EP3157571B1 (enExample)
JP (5) JP6636959B2 (enExample)
KR (2) KR20230056796A (enExample)
CN (3) CN114133443A (enExample)
AP (1) AP2016009585A0 (enExample)
AU (1) AU2015280351C1 (enExample)
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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
CN103533951B (zh) 2011-04-08 2017-04-19 安姆根有限公司 使用生长分化因子15(gdf‑15)治疗或改善代谢障碍的方法
CN105980400B (zh) 2013-07-31 2021-05-07 美国安进公司 生长分化因子15(gdf-15)构建体
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
EA201791238A1 (ru) 2014-12-04 2018-02-28 Новартис Аг Способы и композиции, в которых используются варианты полипептидов klotho
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