TWI750725B - 新穎脂肪酸及其於共軛至生物分子之用途 - Google Patents

新穎脂肪酸及其於共軛至生物分子之用途 Download PDF

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TWI750725B
TWI750725B TW109123095A TW109123095A TWI750725B TW I750725 B TWI750725 B TW I750725B TW 109123095 A TW109123095 A TW 109123095A TW 109123095 A TW109123095 A TW 109123095A TW I750725 B TWI750725 B TW I750725B
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conjugate
acid
mmol
peptide
gdf15
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TW109123095A
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TW202039004A (zh
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大衛 溫英傑 伯尼斯
山田健
去克溫杜 伊比邦久
阿洛克許 都塔羅伊
路易斯 克萊爾 可曼
亞立山卓 馬歇爾 布魯斯
愛咪 瑞察德森 優瑟拉
佛瑞德利克 查克利
強 元
樓長剛
艾倫 肯特
愛薇洛普 博斯
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瑞士商諾華公司
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TW109123095A 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途 TWI750725B (zh)

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US201462015862P 2014-06-23 2014-06-23
US62/015,862 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US62/082,327 2014-11-20
US201562107016P 2015-01-23 2015-01-23
US62/107,016 2015-01-23

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TW104120074A TWI701048B (zh) 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途
TW110136772A TWI792596B (zh) 2014-06-23 2015-06-22 新穎脂肪酸及其於共軛至生物分子之用途

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US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US10752664B2 (en) 2011-04-08 2020-08-25 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
EA037355B1 (ru) 2013-07-31 2021-03-17 Эмджен Инк. Конструкции на основе фактора дифференцировки и роста 15 (gdf-15)
US10588980B2 (en) * 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
MX2017007303A (es) 2014-12-04 2017-08-25 Novartis Ag Metodos y composiciones que utilizan polipeptidos variantes klotho.
CU20170093A7 (es) 2015-01-23 2017-09-06 Novartis Ag Conjugados de ácidos grasos y apelina sintética con mayor vida media
JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts 十分に安定化された非対称sirna
CA2995110A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
CN108367053A (zh) * 2015-12-22 2018-08-03 诺华股份有限公司 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法
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