KR20190135545A - 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 - Google Patents

고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 Download PDF

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KR20190135545A
KR20190135545A KR1020197034945A KR20197034945A KR20190135545A KR 20190135545 A KR20190135545 A KR 20190135545A KR 1020197034945 A KR1020197034945 A KR 1020197034945A KR 20197034945 A KR20197034945 A KR 20197034945A KR 20190135545 A KR20190135545 A KR 20190135545A
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alkyl
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unsubstituted
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carbamoyl
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브로니슬라바 제두린
마이클 그레이
니얼 오도넬
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루메나 파마수티컬즈, 인코포레이티드
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Priority to KR1020217033783A priority Critical patent/KR20210131431A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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KR1020197034945A 2011-10-28 2012-10-26 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 Ceased KR20190135545A (ko)

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KR1020217033783A KR20210131431A (ko) 2011-10-28 2012-10-26 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제

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US201161553094P 2011-10-28 2011-10-28
US61/553,094 2011-10-28
US201261607487P 2012-03-06 2012-03-06
US61/607,487 2012-03-06
PCT/US2012/062303 WO2013063526A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

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