KR20180118175A - 다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도 - Google Patents

다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도 Download PDF

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KR20180118175A
KR20180118175A KR1020187027995A KR20187027995A KR20180118175A KR 20180118175 A KR20180118175 A KR 20180118175A KR 1020187027995 A KR1020187027995 A KR 1020187027995A KR 20187027995 A KR20187027995 A KR 20187027995A KR 20180118175 A KR20180118175 A KR 20180118175A
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seq
amino acid
car
cell
acid sequence
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글렌 드라노프
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노파르티스 아게
더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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KR1020187027995A 2016-03-04 2017-03-03 다중 키메라 항원 수용체 (car) 분자를 발현하는 세포 및 그에 따른 용도 Ceased KR20180118175A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662303466P 2016-03-04 2016-03-04
US62/303,466 2016-03-04
PCT/IB2017/051267 WO2017149515A1 (en) 2016-03-04 2017-03-03 Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore

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KR20180118175A true KR20180118175A (ko) 2018-10-30

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US (2) US20200281973A1 (enExample)
EP (1) EP3423482A1 (enExample)
JP (1) JP2019513347A (enExample)
KR (1) KR20180118175A (enExample)
CN (1) CN109153714A (enExample)
AU (1) AU2017225733A1 (enExample)
BR (1) BR112018067679A2 (enExample)
CA (1) CA3016287A1 (enExample)
IL (1) IL261525A (enExample)
MX (1) MX2018010733A (enExample)
RU (1) RU2018134771A (enExample)
SG (1) SG11201807489PA (enExample)
WO (1) WO2017149515A1 (enExample)

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US11175293B1 (en) 2021-01-04 2021-11-16 University Of Utah Research Foundation Rapid assay for detection of SARS-CoV-2 antibodies
KR20230094450A (ko) 2021-12-21 2023-06-28 한림대학교 산학협력단 항-cldn18.2를 포함하는 키메릭 항원 수용체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 제조 방법
WO2024101962A1 (ko) * 2022-11-11 2024-05-16 주식회사 유씨아이테라퓨틱스 유전자 조작된 세포 및 이의 용도

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US9783591B2 (en) 2012-02-22 2017-10-10 The Trustees Of The University Of Pennsylvania Use of the CD2 signaling domain in second-generation chimeric antigen receptors
EP2958943B1 (en) 2013-02-20 2019-09-11 The Trustees Of The University Of Pennsylvania Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
US9745368B2 (en) 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
JP6793902B2 (ja) 2013-12-20 2020-12-02 ノバルティス アーゲー 調節可能キメラ抗原受容体
ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
JP7054622B2 (ja) 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
ES2791248T3 (es) 2014-08-19 2020-11-03 Novartis Ag Receptor antigénico quimérico (CAR) anti-CD123 para su uso en el tratamiento del cáncer
US11459390B2 (en) 2015-01-16 2022-10-04 Novartis Ag Phosphoglycerate kinase 1 (PGK) promoters and methods of use for expressing chimeric antigen receptor
US9777064B2 (en) 2015-03-17 2017-10-03 Chimera Bioengineering, Inc. Smart CAR devices, DE CAR polypeptides, side CARs and uses thereof
JP6961490B2 (ja) 2015-04-08 2021-11-05 ノバルティス アーゲー Ｃｄ２０療法、ｃｄ２２療法、およびｃｄ１９キメラ抗原受容体（ｃａｒ）発現細胞との併用療法
WO2016168595A1 (en) 2015-04-17 2016-10-20 Barrett David Maxwell Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
WO2017222593A1 (en) * 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
AR105433A1 (es) 2015-07-21 2017-10-04 Novartis Ag Métodos para mejorar la eficacia y expansión de las células inmunes
EP3331913A1 (en) 2015-08-07 2018-06-13 Novartis AG Treatment of cancer using chimeric cd3 receptor proteins
WO2017040930A2 (en) 2015-09-03 2017-03-09 The Trustees Of The University Of Pennsylvania Biomarkers predictive of cytokine release syndrome
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
EP3458077A4 (en) 2016-05-17 2020-04-01 Chimera Bioengineering Inc. METHODS OF MANUFACTURING NEW AREAS OF ANTIGEN BINDING
EP3494132A4 (en) 2016-08-03 2020-03-18 Washington University Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
EP3858365B1 (en) 2016-09-01 2024-01-31 Chimera Bioengineering Inc. Gold optimized car t-cells
WO2018067992A1 (en) 2016-10-07 2018-04-12 Novartis Ag Chimeric antigen receptors for the treatment of cancer
US10617720B2 (en) * 2016-10-20 2020-04-14 Miltenyi Biotech, GmbH Chimeric antigen receptor specific for tumor cells
AU2017363278B2 (en) 2016-11-22 2022-10-27 National University Of Singapore Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies
US11535662B2 (en) 2017-01-26 2022-12-27 Novartis Ag CD28 compositions and methods for chimeric antigen receptor therapy
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
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US20200281973A1 (en) 2020-09-10
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