TW202306997A - 用於在過繼細胞療法中提供標靶共刺激之受體 - Google Patents

用於在過繼細胞療法中提供標靶共刺激之受體 Download PDF

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TW202306997A
TW202306997A TW111122277A TW111122277A TW202306997A TW 202306997 A TW202306997 A TW 202306997A TW 111122277 A TW111122277 A TW 111122277A TW 111122277 A TW111122277 A TW 111122277A TW 202306997 A TW202306997 A TW 202306997A
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約翰 布里喬曼
羅伯特 霍金斯
魯班 羅卓古茲
葛瑞 古班魯瓦
米琳娜 卡萊西道
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英商英斯特生物科技有限公司
美商英斯特生物科技股份有限公司
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Abstract

本文所提供之一些實施例係可用於過繼細胞療法(ACT)之嵌合共刺激抗原受體(CoStAR)及包括該CoStAR之細胞。在一些實施例中，該CoStAR可用作增強對界定抗原之反應之細胞活性調節劑。在一些實施例中，亦提供CoStAR及/或融合蛋白、編碼該CoStAR之核酸及其治療用途。

Description

用於在過繼細胞療法中提供標靶共刺激之受體
本發明係關於可用於過繼細胞療法(ACT)中之嵌合共刺激抗原受體(CoStAR)及包括該CoStAR之細胞。該CoStAR可用作增強對界定抗原之反應之細胞活性調節劑。本發明亦提供CoStAR及/或融合蛋白、編碼該CoStAR之核酸及其治療用途。
使用自體T細胞來介導癌症消退之過繼細胞療法(ACT)已在早期臨床試驗中展示遠大前景。已採取若干一般方式，例如使用離體擴增之天然腫瘤反應性或腫瘤浸潤淋巴球(TIL)。另外，可基因修飾T細胞以使其再靶向指定腫瘤抗原。此可經由基因轉移肽(p)-主要組織相容性複合物(MHC)特異性T細胞受體(TCR)或腫瘤特異性單鏈抗體片段(scFv)與T細胞信號傳導結構域(例如CD3ζ)之間之合成融合體(後者稱為嵌合抗原受體(CAR))來進行。
TIL及TCR轉移已證實在靶向黑色素瘤時尤其良好(Rosenberg等人，2011；Morgan 2006)，而CAR療法已展示在治療某些B細胞惡性腫瘤中具有遠大前景(Grupp等人，2013)。
共刺激信號可用於達成穩定之CAR T細胞擴增、功能、持久性及抗腫瘤活性。CAR療法在白血病中之成功部分地歸因於將共刺激結構域(例如CD28或CD137)納入CAR構築體中，來自該等共刺激結構域之信號與由CD3ζ提供之信號協同作用以增強抗腫瘤活性。此觀察之基礎涉及T細胞活化之經典信號1/信號2範式。此處，由TCR複合物提供之信號1與由共刺激受體(例如CD28、CD137或CD134)提供之信號2協同作用以允許細胞進行純系擴增、IL2產生及長期存活，且並無與單獨信號1有關之活化誘導性細胞死亡(AICD)。另外，信號2之參與增強了經由信號1生成之信號，從而使得細胞更佳地對低親合力相互作用(例如在抗腫瘤反應期間遇到者)作出反應。
對於本申請案中任一文件之引用或認同並不承認該文件可用作本發明之先前技術。
本文提供結合至癌胚抗原(CEA)及/或間皮素(MSLN)之新穎嵌合共刺激抗原受體(CoStAR)；及包括或表現有益於基於CAR及非CAR之T細胞療法二者之CoStAR之細胞。本文提供表現新穎嵌合共刺激受體以在T細胞與指定疾病相關(例如腫瘤相關)抗原銜接時向其提供共刺激信號之細胞。
在若干報導中，使用分裂信號1及信號2來驅動經改造T細胞中之抗原特異性反應(Alvarez-Vallina & Hawkins 1996)。然而，尚未利用全長CD28分子。與截短形式相比，使用全長受體(例如CD28)具有特殊優點。全長受體可能能夠發生二聚合，從而使得受體能夠以其天然形式發揮作用；實際上，嵌合抗原受體不能在表現為單體時發揮最佳功能(Bridgeman等人，2010)。
在一實施例中，在與界定抗原(例如疾病相關或腫瘤相關抗原)銜接時，CoStAR會誘導信號2。全長CD28分子含有對於其結合B7受體家族之成員之天然功能至關重要之模體；儘管自攜載串聯CD28及CD3ζ受體之CAR之角度考慮此係潛在危險(其中CAR與B7之連接可觸發T細胞活化)，但僅含信號2受體之受體具有有益性質。本文提供標靶嵌合共刺激受體(CoStAR)，其包括操作性連接至跨膜結構域之細胞外結合結構域、第一信號傳導結構域及CD40信號傳導結構域或其信號傳導片段。已發現，包括CD40信號傳導結構域之共刺激受體顯示新穎及改良之活性特徵。
在一些實施例中，CD40信號傳導結構域包括SEQ ID NO:32、SEQ ID NO:33或SEQ ID NO:34。在一些實施例中，CD40信號傳導片段包括SH3模體(KPTNKAPH, SEQ ID NO:35)、TRAF2模體(PKQE, SEQ ID NO:36, PVQE, SEQ ID NO:37, SVQE, SEQ ID NO:38)、TRAF6模體(QEPQEINFP, SEQ ID NO:39)、PKA模體(KKPTNKA, SEQ ID NO:40, SRISVQE, SEQ ID NO:41)或其組合，或係全長CD40細胞內結構域。在一些實施例中，CD40信號傳導結構域之SH3、TRAF2、TRAF6或PKA模體中之一或多者發生突變。
在一些實施例中，CoStAR之第一信號傳導結構域包括諸如腫瘤壞死因子受體超家族(TNFRSF)受體等受體之信號傳導結構域或信號傳導片段，該受體包含(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、DAP10、NTKR、CD357 (GITR)或EphB6。在一些實施例中，CoStAR包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、DAP10、NTKR、CD357 (GITR)或EphB6。在實施例中，其中第一信號傳導結構域包括CD40信號傳導結構域，由此CoStAR包括兩個CD40信號傳導結構域之元件。
在一些實施例中，CoStAR包括諸如腫瘤壞死因子受體超家族(TNFRSF)受體等受體之第二信號傳導結構域或信號傳導片段，該受體包含(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6。第一信號傳導結構域或信號傳導片段、CD40信號傳導結構域或信號傳導片段及第二信號傳導結構域或信號傳導片段可呈任何順序。實例性實施例包含(但不限於)包括CD28、CD137及CD40信號傳導結構域、CD28、CD134及CD40信號傳導結構域、CD28、CD2及CD40信號傳導結構域、CD28、GITR及CD40信號傳導結構域、CD28、CD29及CD40信號傳導結構域或CD28、CD150及CD40信號傳導結構域之CoStAR。
在一些實施例中，本發明CoStAR之細胞外抗原結合結構域(例如(但不限於) CEA結合結構域、MSLN結合結構域)藉由連接體及/或間隔體操作性連接至跨膜結構域。在一些實施例中，連接體包括約5至約20個胺基酸。在一些實施例中，連接體包括AAAGSGGSG (SEQ ID NO:18)。
在一些實施例中，CoStAR包括操作性連接細胞外結合結構域與跨膜結構域且包括約10至約250個胺基酸之間隔體。在一些實施例中，間隔體包括CD8或CD28或其片段之細胞外序列。在一些實施例中，CoStAR包括第二細胞外結合結構域。在一些實施例中，第二結合結構域包括來自CD8或CD28之細胞外配體結合結構域。在一些實施例中，間隔體包括一或多個免疫球蛋白結構域或免疫球蛋白恆定區。在一些實施例中，間隔體包括一或多個免疫球蛋白結構域或免疫球蛋白恆定區，例如(但不限於) SEQ ID NO:24。
在一些實施例中，CoStAR之跨膜結構域包括TNFRSF蛋白之跨膜結構域。在一些實施例中，CoStAR之跨膜結構域包括CD28或CD8之跨膜結構域。在一些實施例中，CoStAR之跨膜結構域包括CD28或CD8之跨膜序列。
在一些實施例中，CoStAR可用於刺激針對表現腫瘤相關抗原(TAA) (例如(但不限於)癌胚抗原(CEA)、間皮素(MSLN)或其他者)之選定靶之免疫反應。在一些實施例中，CoStAR包括SEQ ID NO:9、SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:13或SEQ ID NO:14之scFv之抗原結合片段，例如包括一個、兩個、三個、四個、五個或全部六個互補決定區(CDR)之片段。在一些實施例中，CoStAR包括SEQ ID NO:9、SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:13或SEQ ID NO:14之scFv。在一些實施例中，CoStAR包括以下各項之scFv之抗原結合片段：a) SEQ ID NO:186、SEQ ID NO:187、SEQ ID NO:188、SEQ ID NO:189、SEQ ID NO:190或SEQ ID NO:191；或b) SEQ ID NO:510、SEQ ID NO:511、SEQ ID NO:512或SEQ ID NO:513，例如包括一個、兩個、三個、四個、五個或全部六個CDR之片段。在一些實施例中，CoStAR包括以下各項之scFv：a) SEQ ID NO:186、SEQ ID NO:187、SEQ ID NO:188、SEQ ID NO:189、SEQ ID NO:190、SEQ ID NO:191；或b) SEQ ID NO:508、SEQ ID NO:509、SEQ ID NO:510、SEQ ID NO:511、SEQ ID NO:512或SEQ ID NO:513。
在一些實施例中，細胞外結合結構域可包括(但不限於) scFv、肽、抗體之抗原結合部分、抗體重鏈可變結構域、抗體輕鏈可變結構域、單一結構域抗體、CEA配體或MSLN配體。
在一些實施例中，CoStAR包括(例如)位於C末端處之CD3ζ信號傳導結構域。
在一些實施例中，CoStAR包括N末端信號肽。在一些實施例中，N末端信號肽係抑瘤素M (OSM)、CD8α、CD2、介白素-2 (IL-2)、顆粒球-巨噬球群落刺激因子(GM-CSF)及人類IgGκ之信號肽。
在一些實施例中，提供編碼CoStAR之核酸。可將核酸最佳化，例如密碼子最佳化以表現於宿主細胞中。在一些實施例中，將核酸密碼子最佳化以表現於人類細胞中。
在一些實施例中，提供編碼且能夠表現CoStAR之載體。
在一些實施例中，提供表現CoStAR之細胞。在一些實施例中，細胞表現兩種或更多種CoStAR，例如細胞表現結合至CEA或MSLN之CoStAR及結合至FOLR1之CoStAR或結合至CA125之CoStAR，例如(但不限於)抗CEA.CD28.CD40及抗CA125.41BB.CD40或抗MSLN.CD28.CD40及抗CA125.41BB.CD40。在一些實施例中，細胞表現結合至CEA之CoStAR及結合至PDL1之CoStAR (例如(但不限於)抗CEA.CD28.CD40及PD1.CD28.CD40)，或表現結合至MSLN之CoStAR及結合至PDL1之CoStAR (例如(但不限於)抗MSLN.CD28.CD40及PD1.CD28.CD40)。
在一些實施例中，經改造以表現CoStAR之細胞包括α-β T細胞、γ-δ T細胞、T調控細胞、TIL、NKT細胞或NK細胞。在一些實施例中，經改造以表現CoStAR之細胞共表現嵌合抗原受體(CAR)或T細胞受體(TCR)。
在一些實施例中，本文提供製備表現CoStAR之細胞之方法，其包括使用編碼及能夠表現CoStAR之載體轉導或轉染細胞。
在一些實施例中，提供藉由以下方式來製備表現CoStAR之細胞群體之方法：轉導或轉染細胞，檢測CoStAR之表現且富集、擴增及/或選擇表現CoStAR之細胞。
在一些實施例中，本文提供藉由投與表現CoStAR之細胞群體來治療個體之疾病之方法。
在一些實施例中，提供嵌合共刺激抗原受體(CoStAR)，其包括：結合至癌胚抗原(CEA)之細胞外結合結構域或結合至間皮素(MSLN)之細胞外結合結構域(其操作性連接至跨膜結構域)以及第一信號傳導結構域及ICOS之細胞內結構域或其信號傳導片段，或第一信號傳導結構域及NTRK1之細胞內結構域或其信號傳導片段，或第一信號傳導結構域及DAP10之細胞內結構域或其信號傳導片段，或第一信號傳導結構域及CD40信號傳導結構域或其信號傳導片段，或第一信號傳導結構域及TRAF2/TRAF3序列、TRAF6序列、TRAF2序列或IProx序列中之一或多者。
在一些實施例中，提供一種CoStAR，其中第一信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。
在一些實施例中，提供一種CoStAR，其中CoStAR包括第二信號傳導結構域。
在一些實施例中，提供一種CoStAR，其中第二信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。
在一些實施例中，提供一種CoStAR，其中CD40信號傳導片段包括SH3模體(KPTNKAPH, SEQ ID NO:35)、TRAF2模體(PKQE, SEQ ID NO:36, PVQE, SEQ ID NO:37, SVQE, SEQ ID NO:38)、TRAF6模體(QEPQEINFP, SEQ ID NO:39)、PKA模體(KKPTNKA, SEQ ID NO:40, SRISVQE, SEQ ID NO:41)或其組合，或係全長CD40細胞內結構域。
在一些實施例中，提供一種CoStAR，其中第一信號傳導結構域包括全長共刺激結構域。
在一些實施例中，提供一種CoStAR，其中細胞外結合結構域藉由連接體及/或間隔體操作性連接至跨膜結構域。
在一些實施例中，提供一種CoStAR，其中連接體包括約5至約20個胺基酸。
在一些實施例中，提供一種CoStAR，其中連接體或間隔體包括約10至約250個胺基酸。
在一些實施例中，提供一種CoStAR，其中CoStAR包括第二細胞外結合結構域。
在一些實施例中，提供一種CoStAR，其中第二細胞外結合結構域包括來自CD8、CD28或ICOS之配體結合結構域。
在一些實施例中，提供一種CoStAR，其中跨膜結構域包括來自CD28、CD8、ICOS、DAP10或NTRK之跨膜結構域。
在一些實施例中，提供一種CoStAR，其中跨膜結構域包括SEQ ID NO:20、SEQ ID NO:21或SEQ ID NO:22之跨膜結構域序列。
在一些實施例中，提供一種CoStAR，其中細胞外結合結構域包括scFv、肽、抗體重鏈可變結構域、抗體輕鏈可變結構域或CEA配體或MSLN配體。
在一些實施例中，提供一種CoStAR，其進一步在C末端處包括信號傳導結構域。
在一些實施例中，提供一種CoStAR，其進一步包括N末端信號肽。
在一些實施例中，提供一種CoStAR，其中N末端信號肽包括抑瘤素M (OSM)、CD8α、CD2、介白素-2 (IL-2)、顆粒球-巨噬球群落刺激因子(GM-CSF)或人類IgGκ之信號肽。
在一些實施例中，提供編碼上述任一CoStAR構築體之核酸。
在一些實施例中，提供一種CoStAR，其中載體包括CoStAR構築體核酸。
在一些實施例中，提供表現上述任一CoStAR之細胞。
在一些實施例中，CoStAR表現細胞包括α-β T細胞、γ-δ T細胞、T調控細胞、TIL、NKT細胞或NK細胞。
在一些實施例中，CoStAR表現細胞共表現CAR或TCR。
在一些實施例中，提供製備CoStAR表現細胞之方法。在一些實施例中，該方法包括使用載體轉導或轉染細胞之步驟。
在一些實施例中，提供製備表現上述任一CoStAR之CoStAR細胞群體之方法。在一些實施例中，該方法包括i)檢測經技術方案19之載體轉染或轉導之細胞之表面上之CoStAR表現；及ii)選擇鑑別為表現CoStAR之細胞。
在一些實施例中，提供一種細胞群體，其富集上文所提供之任一CoStAR構築體之細胞表現。
在一些實施例中，提供治療個體之疾病之方法。在一些實施例中，該方法包括向個體投與CoStAR表現細胞或CoStAR富集之細胞群體之步驟。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：CEA特異性結合結構域，其連接至下一結構域；跨膜結構域，其連接至下一結構域；ICOS結構域，其連接至下一結構域；CD40信號傳導結構域。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：MSLN特異性結合結構域，其連接至下一結構域；跨膜結構域，其連接至下一結構域；CD28結構域，其連接至下一結構域；CD40信號傳導結構域。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：第一序列，其與SEQ ID NO: 12至少70%一致；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 518至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：第一序列，其與SEQ ID NO: 186-191中之任一者至少70%一致；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 25至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：HCDR1，其係SEQ ID NO: 12中之HCDR1；HCDR2，其係SEQ ID NO: 12中之HCDR2；HCDR3，其係SEQ ID NO: 12中之HCDR3；LCDR1，其係SEQ ID NO: 12中之LCDR1；LCDR2，其係SEQ ID NO: 12中之LCDR2；LCDR3，其係SEQ ID NO: 12中之HCDR3。在一些實施例中，該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變。在一些實施例中，融合蛋白進一步包括：第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 515至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 515至少70%一致之ICOS序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。
在一些實施例中，提供融合蛋白。在一些實施例中，融合蛋白包括：HCDR1，其係SEQ ID NO: 186-191中之HCDR1；HCDR2，其係SEQ ID NO: 186-191中之HCDR2；HCDR3，其係SEQ ID NO: 186-191中之HCDR3；LCDR1，其係SEQ ID NO: 186-191中之LCDR1；LCDR2，其係SEQ ID NO: 186-191中之LCDR2；LCDR3，其係SEQ ID NO: 186-191中之HCDR3。在一些實施例中，該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變。在一些實施例中，融合蛋白進一步包括：第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 25至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 19至少70%一致之CD28 TM序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 25至少70%一致之CD28序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。
在一些實施例中，提供細胞治療方法，其包括：a)鑑別個體，其中個體患有表現MSLN或CEA之癌症；及b)投與上述CoSTaR或融合蛋白中之任一者或多者。
在一些實施例中，提供治療表現MSLN或CEA之個體之癌症之方法，該方法包括：a)鑑別個體，其中個體患有表現MSLN或CEA之癌症；及b)投與上述CoSTaR或融合蛋白中之任一者或多者。
因此，在一些實施例中，並不意欲涵蓋任何先前已知產品、製備該產品之製程或使用該產品之方法，從而申請者保留權利並由此揭示對任何先前已知產品、製程或方法之免責聲明。另外應注意，並不意欲涵蓋任何不符合USPTO (35 U.S.C. §112，第一段)或EPO (EPC之第83條)之書面說明要求及賦能要求之產品、製備該產品之製程或使用該產品的方法，從而申請者保留權利並由此揭示對於任何先前所闡述產品、製程該產品之製程或使用該產品之方法的免責聲明。可有利地遵照EPC第53(c)條以及EPC規則28(b)及(c)來實踐各個實施例。明確保留關於明確棄除如下任何實施例之所有權利：其係本申請案譜系或任何其他譜系或任何第三方之任何先前所提出申請案中之申請者之任何授權專利的標的物。本文之任何內容不應解釋為承諾。
應注意，在本發明及尤其申請專利範圍及/或段落中，諸如「包括(comprises、comprised、comprising)」等術語可具有美國專利法賦予其之含義；舉例而言，其可意指「包含(includes、included、including)」及諸如此類；且諸如「基本上由……組成(consisting essentially of及consists essentially of)」等術語具有美國專利法賦予其之含義，舉例而言，其容許存在不明確引述之要素，但排除發現於先前技術中或影響本發明之基本或新穎特性之要素。
該等及其他實施例揭示於下列實施方式中或自其顯而易見並由其涵蓋。
相關申請案及以引用方式之併入
本申請案主張以下申請案之權益：美國臨時申請案第63/211,042號及美國臨時申請案第63/211,046號，皆在2021年6月16日提出申請；美國臨時申請案第63/222,913號，在2021年7月16日提出申請；及美國臨時申請案第63/301,340號，在2022年1月20日提出申請，該等申請案中之每一者之全部內容以引用方式併入本文中。
參照2019年1月22日提出申請之英國專利申請案第1900858.0號、2019年12月20日提出申請之美國專利申請案第62/951,770號、2020年1月20日提出申請之國際申請案PCT/GB2020/050120及2020年7月17日提出申請之美國臨時專利申請案63/053,494及63/053,498。
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包括CD40信號傳導結構域之共刺激受體顯示新穎及改良之活性特徵。可藉由選擇受體蛋白之用於接合至CD40信號傳導結構域之細胞內結構域及/或藉由選擇用以接合至受體蛋白之細胞內結構域的CD40信號傳導結構域元件來調節活性特徵。本文提供重組共刺激抗原受體(CoStAR)，其包括：(i)疾病-或腫瘤相關抗原結合結構域；(ii)第一細胞內區段，其包括受體蛋白之細胞內信號傳導結構域；及(iii) CD40受體蛋白之第二細胞內信號傳導結構域或其信號轉導片段。視情況，CoStAR包括刺激受體蛋白之細胞外區段。在一些實施例中，刺激受體蛋白之細胞外區段能夠結合配體。在一些實施例中，刺激受體蛋白之細胞外區段經截短且不結合配體。在一些實施例中，刺激受體蛋白之細胞外區段用作長度可調節間隔體，從而使得疾病-或腫瘤相關抗原結合結構域位於遠離表現其以(例如)形成更優化免疫突觸之細胞之表面處。在一些實施例中，刺激受體蛋白之細胞外區段及第一細胞內區段包括相同受體蛋白之區段。在一些實施例中，細胞外區段及第一細胞內區段包括不同受體蛋白之區段。CoStAR在疾病或腫瘤抗原結合結構域與第一細胞內結構域之間包括插入跨膜結構域。在存在刺激受體蛋白之細胞外區段時，跨膜結構域插入細胞外區段與第一細胞內信號傳導結構域之間。
在一些實施例中，靶向MSLN之CoStAR包括h-抑瘤素-M信號肽、scFv、連接體、間隔體、跨膜結構域及CD28.CD40細胞內信號傳導結構域。在一些實施例中，融合蛋白包括以下各項中之一或多者：h-抑瘤素-M信號肽、scFv、連接體、間隔體、跨膜結構域及CD28.CD40細胞內信號傳導結構域。
在一些實施例中，靶向MSLN之CoStAR及/或融合蛋白包括SEQ ID NO: 192、210、228、246、264或282。在一些實施例中，靶向MSLN之CoStAR及/或融合蛋白包括SEQ ID NO: 1之第一序列，該第一序列連結至SEQ ID NO: 185-191中之任一者之第二序列，該第二序列連結至SEQ ID NO: 18之第三序列，該第三序列連結至SEQ ID NO: 19之第四序列，該第四序列連結至SEQ ID NO: 25之第五序列，該第五序列連結至SEQ ID NO: 32之第六序列。該等序列可參見圖84。
在一些實施例中，靶向CEA之CoStAR包括h-抑瘤素-M信號肽、scFv、連接體、ICOS結構域及CD40細胞內信號傳導結構域。在一些實施例中，融合蛋白包括以下各項中之一或多者：h-抑瘤素-M信號肽、scFv、連接體、ICOS結構域及CD40細胞內信號傳導結構域。
在一些實施例中，靶向CEA之CoStAR及/或融合蛋白包括SEQ ID NO: 348。在一些實施例中，靶向CEA之CoStAR及/或融合蛋白包括SEQ ID NO: 1之第一序列，該第一序列連結至SEQ ID NO: 12之第二序列，該第二序列連結至SEQ ID NO: 18之第三序列，該第三序列連結至SEQ ID NO: 515之第四序列，該第四序列連結至SEQ ID NO: 32之第五序列。該等序列可參見圖83。
在一些實施例中，CoStAR (及/或融合蛋白)包括下列各項中之一或多者之MSLN scFv：SS1、MN5、HN1、M912、huTP218或P4 (例如如圖84中所繪示)。在一些實施例中，連接體、間隔體、跨膜結構域及細胞內結構域為不同CoStAR所共有。在一些實施例中，改變MSLN scFv並不影響CoStAR之表現。
在一些實施例中，CoStAR (及/或融合蛋白)包括靶向MSLN之scFv。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括信號肽、scFv及細胞內信號傳導結構域。在一些實施例中，經由連接體序列連結靶向MSLN之CoStAR (及/或融合蛋白)之結構域。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括h抑瘤素-M信號肽及細胞內CD28-CD40結構域。在一些實施例中，MSLN靶向結構域包括含有圖84中之SEQ ID NO: 186-191之SS1、M5、HN1、M912、huTP218或P4 scFv中之任一者。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)進一步在scFv與間隔體之間包括具有序列AAAGSG之連接體。在一些實施例中，間隔體係CD28EC間隔體。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)進一步包括CD28跨膜結構域。
在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括與圖84中SEQ ID NO:  192、210、228、246、264或282中之多肽具有75%一致性之序列。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括與圖84中SEQ ID NO:  192、210、228、246、264或282中之多肽具有80%一致性之序列。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括與圖84中SEQ ID NO:  192、210、228、246、264或282中之多肽具有85%一致性之序列。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括與圖84中SEQ ID NO:  192、210、228、246、264或282中之多肽具有90%一致性之序列。在一些實施例中，靶向MSLN之CoStAR (及/或融合蛋白)包括與圖84中SEQ ID NO:  192、210、228、246、264或282中之多肽具有95%一致性之序列。在一些實施例中，圖84中SEQ ID NO:  192、210、228、246、264或282中之靶向MSLN之CoStAR (及/或融合蛋白)具有1個點突變。在一些實施例中，圖84中SEQ ID NO:  192、210、228、246、264或282中之靶向MSLN之CoStAR (及/或融合蛋白)具有2個點突變。在一些實施例中，圖84中SEQ ID NO: 192、210、228、246、264或282中之靶向MSLN之CoStAR (及/或融合蛋白)具有3、4或5個點突變。
在一些實施例中，構築體之MSLN靶向結構域包括SS1、M5、HN1、M912、huTP218或P4 scFv，該scFv包括與圖84中SEQ ID NO: 186-191中之多肽具有至少75%一致性之序列。在一些實施例中，MSLN靶向結構域包括SS1、M5、HN1、M912、huTP218或P4 scFv，該scFv包括與圖84中SEQ ID NO: 186-191中之多肽具有至少80%一致性之序列。在一些實施例中，MSLN靶向結構域包括SS1、M5、HN1、M912、huTP218或P4 scFv，該scFv包括與圖84中SEQ ID NO: 186-191中之多肽具有至少85%一致性之序列。在一些實施例中，MSLN靶向結構域包括SS1、M5、HN1、M912、huTP218或P4 scFv，該scFv包括與圖84中SEQ ID NO: 186-191中之多肽具有至少90%一致性之序列。在一些實施例中，MSLN靶向結構域包括SS1、M5、HN1、M912、huTP218或P4 scFv，該scFv包括與圖84中SEQ ID NO: 186-191中之多肽具有至少95%一致性之序列。在一些實施例中，圖84中SEQ ID NO: 186-191中之靶向MSLN之scFV具有1個點突變。在一些實施例中，圖84中SEQ ID NO: 186-191中之靶向MSLN之scFV具有2個點突變。在一些實施例中，圖84中SEQ ID NO: 186-191中之靶向MSLN之scFV具有3、4或5個點突變。
在一些實施例中，CoStAR (及/或融合蛋白)包括CEA.ICOS.CD40配置。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括信號肽、scFv及細胞內信號傳導結構域。在一些實施例中，經由連接體序列連結CEA.ICOS.CD40 CoStAR (及/或融合蛋白)之結構域。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括h抑瘤素-M信號肽、人類化MFE23 VH及VL、人類ICOS Q9Y6W8及人類細胞內CD40結構域。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)進一步在VH與VL之間包括3xG4S連接體。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)進一步在VL與ICOS結構域之間包括具有序列AAAGSGGSG之連接體。
在一些實施例中，任一圖及/或表(例如表7)中之任一序列組分可組合成本文所提供之任一CoStAR配置(例如結合結構域、TM、ICOS或CD28結構域及CD40結構域(以及其他可選間隔體及/或連接體)。在一些實施例中，任一圖及/或表(例如表7)中之任一序列組分可組合成本文所提供之任一融合蛋白配置。該等融合蛋白可包含如本文所提供之胺基酸序列。在一些實施例中，CoStARs及/或融合蛋白與本文所提供之胺基酸序列中之任一者或多者至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致，包含任兩個前述值之間之任何範圍。
在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括與圖83中SEQ ID NO: 348中之多肽具有至少75%一致性之序列。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括與圖83中SEQ ID NO: 348中之多肽具有至少80%一致性之序列。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括與圖83中SEQ ID NO: 348中之多肽具有至少85%一致性之序列。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括與圖83中SEQ ID NO: 348中之多肽具有至少90%一致性之序列。在一些實施例中，CEA.ICOS.CD40 CoStAR (及/或融合蛋白)包括與圖83中SEQ ID NO: 348中之多肽具有至少95%一致性之序列。在一些實施例中，圖83中SEQ ID NO: 348中之CEA.ICOS.CD40 CoStAR (及/或融合蛋白)具有1個點突變。在一些實施例中，圖83中SEQ ID NO: 348中之CEA.ICOS.CD40 CoStAR (及/或融合蛋白)具有2個點突變。在一些實施例中，圖83中SEQ ID NO: 348中之CEA.ICOS.CD40 CoStAR (及/或融合蛋白)具有3、4或5個點突變。
在一些實施例中，CEA靶向結構域包括含有與圖83中SEQ ID NO: 12中之多肽具有至少75%一致性之序列之scFv。在一些實施例中，CEA靶向結構域包括含有與圖83中SEQ ID NO: 12中之多肽具有至少80%一致性之序列之scFv。在一些實施例中，CEA靶向結構域包括含有與圖83中SEQ ID NO: 12中之多肽具有至少85%一致性之序列之scFv。在一些實施例中，CEA靶向結構域包括含有與圖83中SEQ ID NO: 12中之多肽具有至少90%一致性之序列之scFv。在一些實施例中，CEA靶向結構域包括含有與圖83中SEQ ID NO: 12中之多肽具有至少95%一致性之序列之scFv。在一些實施例中，圖83中SEQ ID NO: 12中之靶向CEA之scFV具有1個點突變。在一些實施例中，圖83中SEQ ID NO: 12中之靶向CEA之scFV具有2個點突變。在一些實施例中，圖83中SEQ ID NO: 12中之靶向CEA之scFV具有3、4或5個點突變。
在一些實施例中，融合蛋白包括：CEA特異性結合結構域，其連接至下一結構域；跨膜結構域，其連接至下一結構域；ICOS結構域，其連接至下一結構域；CD40信號傳導結構域。
在一些實施例中，融合蛋白包括：MSLN特異性結合結構域，其連接至下一結構域；跨膜結構域，其連接至下一結構域；CD28結構域，其連接至下一結構域；CD40信號傳導結構域。
在一些實施例中，融合蛋白包括：第一序列，其與SEQ ID NO: 12至少70%一致；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 518至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白包括：第一序列，其與SEQ ID NO: 186-191中之任一者至少70%一致；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 25至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白包括：HCDR1，其係SEQ ID NO: 12中之HCDR1；HCDR2，其係SEQ ID NO: 12中之HCDR2；HCDR3，其係SEQ ID NO: 12中之HCDR3；LCDR1，其係SEQ ID NO: 12中之LCDR1；LCDR2，其係SEQ ID NO: 12中之LCDR2；LCDR3，其係SEQ ID NO: 12中之HCDR3，其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 515至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 515至少70%一致之ICOS序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。
在一些實施例中，融合蛋白包括：HCDR1，其係 SEQ ID NO: 186-191中之HCDR1；HCDR2，其係SEQ ID NO: 186-191中之HCDR2；HCDR3，其係SEQ ID NO: 186-191中之HCDR3；LCDR1，其係 SEQ ID NO: 186-191中之LCDR1；LCDR2，其係SEQ ID NO: 186-191中之LCDR2；LCDR3，其係SEQ ID NO: 186-191中之HCDR3，其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變；第二序列，其係跨膜結構域；第三序列，其與SEQ ID NO: 25至少70%一致；及第四序列，其與SEQ ID NO: 32至少70%一致。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 19至少70%一致之CD28 TM序列。
在一些實施例中，融合蛋白進一步包括與SEQ ID NO: 25至少70%一致之CD28序列。
如本文中所使用，「全長蛋白」或「全長受體」係指受體蛋白，例如CD28受體蛋白。術語「全長」涵蓋在信號肽已裂解後於成熟受體蛋白之N末端處缺乏最多約5個或最多10個胺基酸(例如1、2、3、4、5、6、7、8、9或10個胺基酸)之受體蛋白。舉例而言，儘管可界定受體N末端信號肽之具體裂解位點，但已觀察到確切裂解點之可變性。術語「全長」並不暗示受體N末端信號肽之胺基酸之存在或不存在。在一實施例中，術語「全長」 (例如一些實施例之全長CD28或全長CD40細胞內結構域)涵蓋在信號肽已裂解後於成熟受體蛋白之N末端處缺乏N末端信號肽(缺乏最多約5個(例如1、2、3、4、5個)或最多10個胺基酸)之成熟受體蛋白(例如一些實施例之CD28)。如上文所提及，一些實施例之「全長」 CD28受體或其他受體或腫瘤抗原結合結構域不包含信號肽且可在成熟受體蛋白之N末端處缺乏最多約5個(例如1、2、3、4、5個)或最多10個胺基酸(例如N末端殘基N、K、I、L及/或V)。此展示於諸如SEQ ID No. 433-441等實例性融合體中(應注意，該等融合體可在成熟受體蛋白之N末端處缺乏最多約5個(例如1、2、3、4、5個)或最多10個胺基酸，如加框區中所展示)。
CoStAR具有模組形式且可經構築以包括自一或多種蛋白質獲得之細胞外、跨膜及細胞內結構域以及自結合至疾病相關抗原(例如腫瘤相關抗原)之抗體獲得之scFv。
在一些實施例中，CoStAR包括疾病相關(例如腫瘤相關)之抗原受體(例如(但不限於)腫瘤相關之抗原特異性scFv)及能夠結合至同族配體並提供細胞內信號之一級共刺激受體蛋白。在一些實施例中，一級共刺激受體可小於全長蛋白，但足以結合同族配體並轉導信號。在一些實施例中，一級共刺激受體結構域係全長的，例如(但不限於)全長CD28。因此，抗原特異性結合結構域及配體特異性受體分別能夠結合同族抗原及配體。本文所提供之胺基酸序列提供若干CoStAR構築體之實施例。該等構築體包含含有抗原結合結構域、可選間隔體、包括細胞外配體結合區段之可選共刺激受體蛋白或其片段及細胞內CD40信號傳導結構域之CoStAR構築體。在另一實施例中，CoStAR包括抗原結合結構域、可選間隔體、共刺激受體蛋白之細胞外配體結合部分、跨膜結構域及選定共刺激受體蛋白之細胞內信號傳導結構域以及細胞內CD40信號傳導結構域。在一些實施例中，細胞外配體結合部分包括CD28截短(例如胺基酸IEV後之C末端CD28截短)，且隨後係細胞內信號傳導結構域。在一些實施例中，細胞內信號傳導結構域係來自CD40。分隔細胞外配體結合結構域及細胞內信號傳導結構域之跨膜結構域可來自(但不限於) CD28、CD40。在其他實施例中，CoStAR可包括其他共刺激結構域(例如第三、細胞內共刺激信號傳導結構域)且由此可類似於某些嵌合抗原受體(CAR)，該等嵌合抗原受體分成第一代(僅CD3ζ)、第二代(一共共刺激結構域+ CD3ζ)或第三代(一個以上共刺激結構域+ CD3ζ)。
可用於CoStAR中之共刺激受體蛋白可包含(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6，其天然形式包括細胞外配體結合結構域及細胞內信號轉導結構域。舉例而言，將CD2描述為發現於T細胞表面上之細胞黏附分子且能夠引發T細胞活化所需之細胞內信號。將CD27描述為屬TNFR超家族(TNFRSF)之II型跨膜醣蛋白，其在B細胞上之表現係由B細胞中之抗原受體活化所誘導。CD28係T細胞中之一種蛋白質且係抗原呈現細胞上之CD80 (B7.1)及CD86 (B7.2)配體之受體。CD137 (4-1BB)配體發現於大部分白血球及一些非免疫細胞上。OX40配體表現於許多抗原呈現細胞(例如DC2 (樹突狀細胞)、巨噬球及B淋巴球)上。在一實施例中，共刺激受體蛋白係如本文所定義之全長CD28。
CD40係腫瘤壞死因子受體(TNFR)超家族之成員且若干同種型係藉由選擇式剪接所生成。其配體CD154 (亦稱為CD40L)係主要表現於活化T細胞上之蛋白質。作為參考，人類CD40同種型1蛋白質序列列示於基因庫登錄號：NP_001241.1中，其包含信號肽(胺基酸1-20)、跨膜結構域(胺基酸194-215)及細胞質結構域(胺基酸216-277)(SEQ ID NO:32)。CD40受體信號傳導涉及轉接蛋白(包含(但不限於) TNF受體相關因子(TRAF))，且CD40細胞質結構域包括信號傳導組分，包含適用於SH3模體(KPTNKAPH) (SEQ ID NO:35)、TRAF2模體(PKQE  (SEQ ID NO:36)、PVQE (SEQ ID NO:37)、SVQE (SEQ ID NO:38))、TRAF6模體(QEPQEINFP) (SEQ ID NO:39)及PKA模體(KKPTNKA (SEQ ID NO:40)、SRISVQE (SEQ ID NO:41))之胺基酸序列。一些實施例包含含有結合TRAF之胺基酸序列之經改造信號傳導結構域，例如經改造CD40信號傳導結構域。結合至TRAF1、TRAF2、TRAF3及TRAF5經改造信號傳導結構域可包括主要共有序列(P/S/A/T)X(Q/E)E或次要共有序列PXQXXD，且可鑑別於或獲得自(但不限於) TNFR家族成員(例如CD30、OX40、41BB)及EBV致癌蛋白LMP1。(例如參見Ye, H等人， The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2. Molecular Cell, 1999; 4(3):321-30. doi: 10.1016/S1097-2765(00)80334-2；Park HH, Structure of TRAF Family: Current Understanding of Receptor Recognition. Front. Immunol. 2018; 9:1999. doi: 10.3389/fimmu.2018.01999；Chung, J.Y.等人， All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. Journal of Cell Science 2002; 115:679-688)。
本文所揭示之實例證實，CD40可用作CoStAR中之共刺激信號傳導結構域且另外藉由信號傳導結構域選擇來改變細胞介素及趨化介素之表現特徵。在一些實施例中，CoStAR之共刺激CD40信號傳導結構域增加了促發炎性細胞介素(例如IL-2、TNFα)。在一些實施例中，CoStAR之共刺激CD40信號傳導結構域減少了免疫抑制性細胞介素(例如IL-5、IL-10)。與第一受體信號傳導結構域(例如(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6)在不含CD40信號傳導結構域或片段之情形下之活性相比，CD40信號傳導結構域或片段之共刺激活性可在與第一受體信號傳導結構域之組合中觀察到。就此而言，與僅第一信號傳導結構域(共刺激信號傳導結構域之活性)相比，CD40信號傳導結構域(包含含有特定因素結合位點或其中特定因素結合位點發生突變之信號傳導片段)與共刺激第一信號傳導結構域之組合能夠促進或抑制特定細胞介素及/或趨化介素之相對表現。例如參見Ahonen, CL等人， The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. Nat Immunol. 2002; 3: 451-456；Mackey MF等人， Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. Eur J Immunol. 2003; 33: 779-789；Mukundan等人， TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J Immunol. 2005; 174: 1081-1090。
在一些實施例中，CoStAR包括實質上所有之CD40共刺激結構域。在一些實施例中，CoStAR包括兩個或更多個CD40共刺激結構域。在一些實施例中，CoStAR包括CD40共刺激結構域信號傳導組分或片段或模體。在一些實施例中，CD40信號傳導片段或模體包括以下各項、由其組成或基本上由其組成：SH3結合序列(例如(但不限於) KPTNKAPH (SEQ ID NO:35)、PTNKAPHP (SEQ ID NO:443)或PTNKAPH (SEQ ID NO:444))、TRAF2/TRAF3結合序列(例如(但不限於) PKQE (SEQ ID NO:506)、PKQET (SEQ ID NO:445)、PVQE (SEQ ID NO:507)、PVQET (SEQ ID NO:446)、SVQE (SEQ ID NO:508)、SVQET (SEQ ID NO:447))、TRAF6結合序列(例如(但不限於) PQEINF (SEQ ID NO:509)、QEPQEINF (SEQ ID NO:448)或QEPQEINFP (SEQ ID NO:39))或PKA序列(例如(但不限於) KKPTNKA (SEQ ID NO:40)或SRISVQE (SEQ ID NO:41)以及兩種或更多種或三種或更多種或四種或更多種此類組分或模體或其組合，該等序列可為多個拷貝並以任何順序配置。在一些實施例中，CoStAR包括CD40共刺激結構域及CD40共刺激結構域信號傳導組分或模體。在一些實施例中，CD40信號傳導結構域之SH3、TRAF2/TRAF3、TRAF6或PKA模體中之一或多者發生突變。在一些實施例中，SH3模體、TRAF2/TRAF3模體及TRAF6模體足以調節促發炎性及/或免疫抑制性細胞介素。在一些實施例中，添加該等模體之串聯拷貝及/或使某些模體發生突變可擴大該等效應。
表1 提供TRAF2/TRAF3結合序列之非限制性實例。
表1 -實例性TRAF2/TRAF3結合序列
來源 P-4 P-3 P-2 P-1 P0 P1 P2 P3 P4 P5 P6 SEQ ID NO.
hTNFR2 P F S K E E C A F R S 450
hCD40 A A P V Q E T L H G C 451
hCD30 M L S V E E E G K E D 452
hCD27 T I P I Q E D Y R K P 453
hLTβR S T P H Q E D G K A W 454
hATAR T V A V E E T I P S T 455
hOX40 R T P I Q E E Q A D A 456
m41BB T G A A Q E E D A C S 457
m41BB R C P Q E E E G G G G 458
h41BB V Q T T Q E E D G C S 459
h41BB R F P E E E E G G C E 460
bLMP1 R T P V Q E S G Y P D 461
bLMP1 R P P V Q E T G G G G 462
bLMP1 H P P V Q E T G G G G 463
bLMP1 H P P V Q E T G E G G 464
bLMP1 H P P I Q E T G N G G 465
LAT A L S S Q E A E E V E 466
hTANK S V P I Q C T D K T D 467
hLMP1 P H P Q Q A T D D S S 468
rLMP1 P Y P I Q A T D G G N 469
rLMP1 P H P I Q A T D G A N 470
rLMP1 P Y P V Q A S D G G D 471
次要共有 P/S/A/T X Q/E E 472
主要共有       P V Q E                473
因此，一些實施例之TRAF2/TRAF3結合序列進一步包含某些序列，例如P 1V 2Q 3E 4及P 1經S、A或T取代、V 2經Q、K或E取代、Q 3經E取代且/或E 4經A取代之變體。在該等變體中，P 1V 2Q 3E 4中之任一者、兩者、三者或全部四者可經取代。非限制性實例展示於表1中之位置P-2、P-1、P0、P1處。
CD40 TRAF2/TRAF3序列變體之闡釋性非限制性實例包含下列變體，P-2、P-1、P0及P1處之胺基酸由破折號括起，且指示TRAF2/TRAF3源蛋白。
表2 -實例性CD40 TRAF2/TRAF3變體
SEQ ID NO: 基於CD40之胺基酸序列 TRAF2/3序列源
474 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--PVQE--TLHGCQPVTQEDGKESRI--SVQE--RQ CD40 WT
475 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--TQEE--TLHGCQPVTQEDGKESRISVQERQ CD40/ v41BB
476 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--SKEE--TLHGCQPVTQEDGKESRISVQERQ CD40/ vTNFR2
477 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--AVEE--TLHGCQPVTQEDGKESRISVQERQ CD40/ vATAR
478 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRI--AVEE--RQ CD40/ vATAR
479 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRI--PEEE--RQ CD40/ v41BB
表3 提供TRAF2/TRAF3結合序列之非限制性實例。
表3 -實例性TRAF6結合序列
P-2 P-1 P0 P1 P2 P3 SEQ ID NO:
hCD40 P Q E I N F 480
hTRANCE-R P Q E I D F 481
Mal P P E L R F 482
TRIF P E E M S W 483
IRAK (1) P Q E N S Y 484
IRAK (2) P V E S D E 485
IRAK (3) P E E S D E 486
IRAK-2 (1) P E E T D E 487
IRAK-2 (2) P T E N G E 488
IRAK-M P V E D D E 489
RIP2 P P E N Y E 490
MyD88 P S E L R F 491
共有 P X E X X Ac/Ar 492
Ac =酸性殘基；Ar =芳香族殘基   
CD40 TRAF6序列變體之闡釋性非限制性實例包含下列變體，P-2、P-1、P0、P1、P2及P3處之胺基酸由破折號括起，且指示TRAF6序列源。
表4 -實例性CD40 TRAF6變體
SEQ ID No: 基於CD40之胺基酸序列 TRAF6序列源
493 KKVAKKPTNKAPHPKQE--PQEINF--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ CD40 WT
494 KKVAKKPTNKAPHPKQE--PEEMSW--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ CD40/ vTRIF
495 KKVAKKPTNKAPHPKQE--PPENYE--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ CD40/ vRIP2
496 KKVAKKPTNKAPHPKQE--PQENSY--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ CD40/ vIRAK(1)
表5 -實例性CD40 TRAF2/TRAF3/TRAF6共有變體
SEQ ID No: 基於CD40之胺基酸序列變體   
497 KKVAKKPTNKAPHPKQE--PQEINF--PDDLPGSNTAA--PVQE--TLHGCQPVTQEDGKESRI--SVQE--RQ CD40 WT
498 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ   
499 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--(P/S/A/T)X(Q/E)E--TLHGCQPVTQEDGKESRISVQERQ   
500 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E--RQ   
501 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAA--(P/S/A/T)X(Q/E)--ETLHGCQPVTQEDGKESRISVQERQ   
502 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--(P/S/A/T)X(Q/E)E--TLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E--RQ   
503 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E--RQ   
504 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAA--(P/S/A/T)X(Q/E)E--TLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E--RQ   
505 KKVAKKPTNKAPHPKQE--PEELRW--PDDLPGSNTAA--THEE--TLHGCQPVTQEDGKESRI--AIEE--RQ   
Ar =芳香族殘基；Ac =酸性殘基
在一些實施例中，一或多種共刺激結構域信號傳導組分或模體之選擇係由細胞引導，該細胞擬表現CoStAR及/或具有與信號傳導組分或模體更接近地鑑別期望共刺激活性或避免與信號傳導組分或模體更接近地鑑別之共刺激活性。
在一些實施例中，除CD40共刺激結構域或其信號傳導組分或模體或兩個或更多個此類結構域或其組分或模體或組合外，CoStAR信號傳導結構域亦包括來自(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之另一全長共刺激結構域或其信號傳導組分。
作為參考，人類CD28蛋白質序列列示於基因庫登錄號：NP_006130.1中，其包含信號肽(胺基酸1-18)、細胞外結構域(胺基酸19-152)、跨膜結構域(胺基酸153-179)及細胞質結構域(胺基酸180-200)。細胞外結構域包含免疫球蛋白型結構域(胺基酸21-136)，後者含有構成抗原結合位點之胺基酸及形成同源二聚體界面之胺基酸。細胞外結構域包含若干可醣基化之天門冬醯胺酸殘基，且細胞內結構域包括可磷酸化之絲胺酸及酪胺酸殘基。
在一些實施例中，融合蛋白包括連接至CD28信號傳導結構域之CD40信號傳導結構域。在MSLN由scFV識別時，CD40信號傳導結構域可向細胞提供共刺激信號。在一些實施例中，由CD40信號傳導結構域提供之共刺激信號可增強細胞存活及增殖。在MSLN由結合結構域識別時自CD28及CD40信號傳導結構域提供之共刺激信號可足以促進融合蛋白表現細胞之存活及增殖，CD40信號傳導結構域可包括SEQ ID NO: 521。在一些實施例中，CD40信號傳導結構域可包括SH3模體、TRAF2模體(SEQ ID NO:516、517或518)、TRAF6模體(SEQ ID NO: 519)、PKA (SEQ ID NO: 520或521)或其組合，其中序列表展示於表7中。在一些實施例中，CD40結構域只是展示於SEQ ID NO: 521中之胺基酸結構或係與其至少60%、70%、80%、90%、95%、96%、97%、98%、99%或100%一致者。
作為參考，人類CD8 α鏈蛋白質序列由基因庫登錄號：NP_001139345.1列示，其包含信號肽(胺基酸1-21)、細胞外結構域(胺基酸22-182)、跨膜結構域(胺基酸183-203)及細胞質結構域(胺基酸204-235)。細胞外結構域包含免疫球蛋白型結構域(胺基酸28-128)，後者含有構成抗原結合位點之胺基酸及形成同源二聚體界面之胺基酸。細胞外結構域包含若干可醣基化之天門冬醯胺酸殘基，且細胞內結構域包括可磷酸化之絲胺酸及酪胺酸殘基。
作為參考，人類IgG4恆定區序列列示於UniProtKB/Swiss-Prot:登錄號：P01861.1中，其包含CH1 (胺基酸1-98)、鉸鏈(胺基酸99-110)、CH2 (胺基酸111-220)、CH3 (胺基酸221-327)。CH2區在胺基酸177處包含天門冬醯胺酸，該天門冬醯胺酸發生醣基化且與Fc受體及抗體依賴性細胞介導之細胞毒性(ADCC)有關。
作為參考，人類CD137 (4-1BB)，另一TNFR超家族成員之蛋白質序列由基因庫登錄號：NP_001552.2列示，其包含信號肽(胺基酸1-23)、細胞外結構域(胺基酸24-186)、跨膜結構域(胺基酸187-213)及細胞質結構域(胺基酸214-255)。表現於抗原呈現細胞上之CD137L配體三聚體與CD137之結合會使受體發生三聚合並激活涉及T細胞反應性及存活之信號傳導級聯(Li等人， Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Reports 2018; 25:909-920)。已報導CD137與信號傳導轉接子TRAF‐2及TRAF‐1之共免疫沈澱及該等相互作用之結構基礎(Ye, H等人，Molecular Cell, 1999; 4(3):321-30)。
作為參考，人類CD134 (OX40)蛋白質序列由基因庫登錄號：NP_003318.1列示，其包含信號肽(胺基酸1-28)、細胞外結構域(胺基酸29-214)、跨膜結構域(胺基酸215-235)及細胞質結構域(胺基酸236-277)。此受體已展示可經由與轉接蛋白TRAF2及TRAF5相互作用來活化NFκB，且研究表明此受體促進了細胞凋亡抑制劑BCL2及BCL2lL1/BCL2-XL之表現。
人類T細胞表面抗原CD2具有至少兩種同種型。作為參考，人類CD2同種型1蛋白質序列由NP_001315538.1列示，其包含信號肽(胺基酸1-24)、細胞外結構域(胺基酸25-235)、跨膜結構域(胺基酸236-261)及細胞質結構域(胺基酸262-377)。人類CD2同種型2蛋白質序列由NP_001758.2列示。
作為參考，人類CD357 (GITR)同種型-1蛋白質序列由基因庫登錄號：NP_004186.1列示，其包含信號肽(胺基酸1-25)、細胞外結構域(胺基酸26-162)、跨膜結構域(胺基酸163-183)及細胞質結構域(胺基酸184-241)。
作為參考，人類CD29 (β1整聯蛋白)蛋白質序列由基因庫登錄號：NP_596867列示，其包含信號肽(胺基酸1-20)、細胞外結構域(胺基酸21-728)、跨膜結構域(胺基酸729-751)及細胞質結構域(胺基酸752-798)。
人類CD150 (SLAM)蛋白質序列具有若干種同種型。除CD150之跨膜形式(mCD150)外，造血譜系細胞亦表現編碼CD150之分泌形式(sCD150)之mRNA，該分泌形式缺乏具有30個胺基酸之整個跨膜區。作為參考，人類SLAM同種型b由基因庫登錄號：NP_003028.1列示，其包含信號肽(胺基酸1-20)、細胞外結構域(胺基酸21-237)、跨膜結構域(胺基酸238-258)及細胞質結構域(胺基酸259-335)。人類SLAM同種型a由基因庫登錄號：NP_001317683.1列示。
CD278或ICOS (可誘導T細胞共刺激因子)係表現於活化T細胞上之CD28超家族共刺激分子。人類ICOS前體(199 aa且具有信號肽)由基因庫登錄號：NP_036224.1列示，其包含信號肽(胺基酸1-20)、Ig-V樣結構域(胺基酸21-140)、跨膜結構域(胺基酸141-161)及細胞內結構域(胺基酸162-199)。ICOS含有IProx模體序列SSSVHDPNGE (SEQ ID NO:466)。IProx模體序列SSSXXXPXGE (SEQ ID NO:467)類似於TRAF1 (SASFQRPQSE (SEQ ID NO:468))、TRAF2 (SSSFQRPVND (SEQ ID NO:469))、TRAF3 (SSFKKPTGE (SEQ ID NO:470))及TRAF5 (SSSFKRPDGE (SEQ ID NO:471))之某些結合位點。
造血細胞信號轉導子(HCST)亦稱為DAP10、KAP10、PIK3AP及造血細胞信號轉導子(基因庫登錄號：NP_055081.1)編碼跨膜信號傳導轉接子，據信，該跨膜信號傳導轉接子會形成具有C型凝集素樣受體NKG2D之受體複合物之一部分。細胞內結構域含有磷脂醯肌醇3-激酶結合位點之YxxM模體。
在一些實施例中，CoStAR靶向癌胚抗原(CEA)。在一些實施例中，CoStAR靶向間皮素(MSLN)。
在一些實施例中，靶向CEA之CoStAR靶向癌胚抗原相關性細胞黏附分子5 (CEACAM5) (NCBI登錄號：NM_001291484.3)。在一些實施例中，CEA scFv結合至CEACAM5。
在一些實施例中，CoStAR可在啟動子之控制下單獨表現於具有治療活性之治療細胞群體(例如腫瘤浸潤淋巴球(TIL))中。或者，CoStAR可與治療轉基因(例如嵌合抗原受體(CAR)及/或T細胞受體(TCR))一起表現(應注意，可在成熟受體蛋白之N末端處缺乏最多約5個(例如1、2、3、4、5個)或最多10個胺基酸)。因此，一些實施例亦係關於CoStAR構築體，其中並不限於具有如SEQ ID NO:42-185、192-335、344-430中之任一者中所展示之序列者，該序列包含在成熟受體蛋白之N末端處缺乏最多約5個(例如1、2、3、4、5個)或最多10個胺基酸之該等序列中之一者)。適宜TCR及CAR在文獻中已眾所周知，例如已成功地分別用於治療骨髓瘤或B細胞惡性腫瘤之HLA-A*02-NYESO-1特異性TCR (Rapoport等人，Nat Med 2015)或抗CD19scFv.CD3ζ融合CAR (Kochenderfer等人，J Clin Oncol 2015)。本文所闡述之CoStAR可與任何已知CAR或TCR一起表現，由此向細胞提供可調控生長開關以容許活體外或活體內細胞擴增並提供以TCR或CAR形式達成抗癌活性之習用活化機制。因此，一些實施例提供用於過繼細胞療法中之細胞，其包括如本文所闡述之CoStAR及特異性結合至腫瘤相關抗原之TCR及/或CAR。包括CD28之一實例性CoStAR包含細胞外抗原結合結構域以及細胞外、跨膜及細胞內信號傳導結構域。
本文所用之術語「抗原結合結構域」係指抗體片段，包含(但不限於)二價抗體、Fab、Fab’、F(ab’)2、Fv片段、經二硫化物穩定之Fv片段(dsFv)、(dsFv)2、雙特異性dsFv (dsFv-dsFv')、經二硫化物穩定之二價抗體(ds二價抗體)、單鏈抗體分子(scFv)、scFv二聚體(二價抗體)、自包括一或多個CDR之抗體部分形成之多特異性抗體、駱駝化單一結構域抗體、奈米抗體、結構域抗體、二價結構域抗體或結合至抗原之任何其他抗體片段；但不包括完整抗體結構。抗原結合結構域能夠與親代抗體或親代抗體片段(例如親代scFv)結合結合至相同抗原。在一些實施例中，抗原結合片段可包括一或多個來自特定人類抗體之接枝至來自一或多種不同人類抗體之框架(FR)之互補決定區(CDR)。「抗原結合結構域」可稱為「配體結合結構域」。
在一些實施例中，scFV包括與SEQ ID NO: 12中之多肽具有70%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 12中之多肽具有75%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 12中之多肽具有80%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 12中之多肽具有85%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 12中之多肽具有90%一致性之VH及/或VL。在一些實施例中，SEQ ID NO: 12之CDR具有1個點突變。在一些實施例中，SEQ ID NO: 12之CDR具有2個點突變。在一些實施例中，SEQ ID NO: 12之CDR具有3、4或5個點突變。在一些實施例中，序列係展示於 圖 83中者。在一些實施例中，結合結構域僅係根據胺基酸結構來定義，且可為本文關於該等胺基酸結構所提供之彼等序列中之任一者。應瞭解，本文關於CEA所揭示之所有實施例亦適用於表7中之相應配置。
在一些實施例中，圖28中之任一結構配置可與表7或本文任一其他表中之任一序列及/或圖中之任一所示序列或相關序列一起使用。在一些實施例中，表7或本文任一其他表中所揭示HDR1、HCDR2、HCDR3、LCDR1、LCDR2、LCDR3、VH、VL及/或scFV中之任一者及/或圖中之任一所示序列或相關序列可用於圖28中之一或多種配置中。在一些實施例中，任一scFv序列、尤其CEA scFv鑑別序列可以此方式使用。在一些實施例中，任一上述序列或與其至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之任何序列可用於圖28中。在一些實施例中，CoStAR可具有如本文所提供之在功能上表徵或可表徵之組分。在一些實施例中，融合蛋白可具有如本文所提供之僅根據結構定義(例如根據胺基酸或核酸序列)之組分。在一些實施例中，提供包含與SEQ ID NO: 348至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之胺基酸序列之融合蛋白。在一些實施例中，圖83中之任一或多個序列可用於圖28中之配置中，包含與該任一或多個序列至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之任何序列。
在一些實施例中，scFV包括與SEQ ID NO: 186-191中之任一者中之多肽具有70%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 186-191中之任一者中之多肽具有75%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 186-191中之任一者中之多肽具有80%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 186-191中之任一者中之多肽具有85%一致性之VH及/或VL。在一些實施例中，scFV包括與SEQ ID NO: 186-191中之任一者中之多肽具有90%一致性之VH及/或VL。在一些實施例中，SEQ ID NO: 186-191中之任一者之CDR具有1個點突變。在一些實施例中，SEQ ID NO: 186-191中之任一者之CDR具有2個點突變。在一些實施例中，SEQ ID NO: 186-191中之任一者之CDR具有3、4或5個點突變。在一些實施例中，序列係展示於 圖 84中者。在一些實施例中，結合結構域僅係根據胺基酸結構來定義，且可為本文關於該等胺基酸結構所提供之彼等序列中之任一者。應瞭解，本文關於MSLN所揭示之所有實施例亦適用於表7中之相應配置。
在一些實施例中，圖62、63A、64、65、66、67、69B、70A、70B及84A中之任一者或多者中之任一結構配置可與表7或本文任一其他表中之任一序列及/或圖中之任一所示序列或相關序列一起使用。在一些實施例中，表7或本文任一其他表中所揭示HDR1、HCDR2、HCDR3、LCDR1、LCDR2、LCDR3、VH、VL及/或scFV中之任一者及/或圖中之任一所示序列或相關序列可用於圖62、63A、64、65、66、67、69B、70A、70B及84A中之任一者或多者中之一或多種配置中。在一些實施例中，任一scFv序列、尤其CEA scFv鑑別序列可以此方式使用。在一些實施例中，任一上述序列或與其至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之任何序列可用於圖62、63A、64、65、66、67、69B、70B及84A中之任一者中。在一些實施例中，CoStAR可具有如本文所提供之在功能上表徵或可表徵之組分。在一些實施例中，融合蛋白可具有如本文所提供之僅根據結構定義(例如根據胺基酸或核酸序列)之組分。在一些實施例中，提供包含與SEQ ID NO: 192、210、228、246、264及/或282中之任一者或多者至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之胺基酸序列之融合蛋白。在一些實施例中，圖84A-84C中之任一或多個序列可用於圖62、63A、64、65、66、67、69B、70B及84A中之任一者或多者之配置中，包含與該任一或多個序列至少70%、75%、80%、85%、90%、95%、96%、97%、98%、99%或100%一致或類似之任何序列。
可使抗原結合結構域對任何疾病相關抗原(包含(但不限於)腫瘤相關抗原(TAA)及感染性疾病相關抗原)具有特異性。在一些實施例中，配體結合結構域係雙特異性的。已在大部分人類癌症中鑑別到抗原，包含伯基特氏淋巴瘤(Burkitt lymphoma)、神經母細胞瘤、黑色素瘤、骨肉瘤、腎細胞癌、乳癌、前列腺癌、肺癌及結腸癌。TAA包含(但不限於) CD19、CD20、CD22、CD24、CD33、CD38、CD123、CD228、CD138、BCMA、GPC3、CEA、葉酸鹽受體(FRα)、間皮素、CD276、gp100、5T4、GD2、EGFR、MUC-1、PSMA、EpCAM、MCSP、SM5-1、MICA、MICB、ULBP及HER-2。TAA進一步包含新抗原、肽/MHC複合物及HSP/肽複合物。
在一些實施例中，抗原結合結構域包括結合至指定腫瘤特異性肽-MHC複合物之T細胞受體或其結合片段。術語「T細胞受體」或「TCR」係指由在T細胞表面上配對之αβ或γδ鏈構成之異源二聚體受體。每一α、β、γ及δ鏈係由以下兩個Ig樣結構域構成：可變結構域(V)，其經由互補決定區(CDR)賦予抗原識別；隨後係恆定結構域(C)，其藉由連結肽及跨膜(TM)區錨定至細胞膜。TM區與CD3信號傳導裝置之恆定亞單元締合。每一V結構域具有三個CDR。該等CDR與結合至由主要組織相容性複合物(pMHC)編碼之蛋白質之抗原肽之複合物相互作用(Davis及Bjorkman (1988) Nature, 334, 395-402；Davis等人，(1998) Annu Rev Immunol, 16, 523-544；Murphy (2012), xix, 868 p.)。
在一些實施例中，抗原結合結構域包括腫瘤表現蛋白或其腫瘤結合片段之天然配體。一非限制性實例係結合至PDL1之PD1。另一實例係亦稱為CD71之轉鐵蛋白受體1 (TfR1)，其係作為細胞鐵穩態及增殖之關鍵調控因子之同源二聚體蛋白。儘管TfR1以低含量表現於各種細胞中，但其以較高含量表現於快速增殖性細胞(包含過度表現與較差預後有關之惡性細胞)中。在一些實施例中，抗原結合結構域包括轉鐵蛋白或其轉鐵蛋白受體結合片段。
在一些實施例中，抗原結合結構域對指定腫瘤相關抗原(例如(但不限於) FRα、CEA、5T4、CA125、SM5-1或CD71)具有特異性。在一些實施例中，腫瘤相關抗原可為腫瘤特異性肽-MHC複合物。在某些此類實施例中，肽係新抗原。在其他實施例中，腫瘤相關抗原係肽-熱激蛋白複合物。
在一些實施例中，結合結構域使癌症治療特異性靶向表現CEA或MSLN之癌細胞。在一些實施例中，結合結構域可包括scFv、肽、抗體重鏈、天然配體或CEA或MSLN特異性受體。在一些實施例中，結合結構域可包括含有scFv之多肽，該scFv具有包括SEQ ID NO: 186-191中之任一者之序列，其中序列展示於 圖 84中 。在一些實施例中，結合結構域可藉由連接體及/或間隔體連接至跨膜結構域。在一些實施例中，結合結構域係SEQ ID NO: 185-191中者。在一些實施例中，結合結構域與SEQ ID NO: 186-191中者(或圖84中之不同靶之任一相應序列)至少70%、80%、90%、95%、96%、97%、98%、99%或100%一致。在一些實施例中，結合結構域包括與SEQ ID NO: 12中之VH及/或VL至少70%、80%、90%、95%、96%、97%、98%、99%或100%一致之VH及/或VL (或圖83中針對不同靶(例如針對MSLN或CEA)之任一相應序列)。在一些實施例中，結合結構域包括與SEQ ID NO: 186-191及12中之HCDR1、HCDR2、HCDR3、LCDR1、LCDR2及/或LCDR3至少70%、80%、90%或100%一致之HCDR1、HCDR2、HCDR3、LCDR1、LCDR2及/或LCDR3 (或圖83或84中針對不同靶之任一相應序列)。
在一些實施例中，CoStAR包括：
i.結合至癌胚抗原(CEA)或間皮素(MSLN)之scFv、CD28之間隔體及跨膜序列、ICOS結構域或CD28信號傳導結構域及CD40信號傳導結構域。
ii.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列以及CD40信號傳導結構域。
iii.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、CD137信號傳導結構域及CD40信號傳導結構域。
iv.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、CD134信號傳導結構域及CD40信號傳導結構域。
v.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、CD2信號傳導結構域及CD40信號傳導結構域。
vi.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、GITR信號傳導結構域及CD40信號傳導結構域。
vii.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、CD29信號傳導結構域及CD40信號傳導結構域。
viii.結合至CEA或MSLN之scFv、CD28之間隔體及跨膜序列、CD150信號傳導結構域及CD40信號傳導結構域。
ix.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD28信號傳導結構域及CD40信號傳導結構域。
x.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列以及CD40信號傳導結構域。
xi.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD137信號傳導結構域及CD40信號傳導結構域。
xii.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD134信號傳導結構域及CD40信號傳導結構域。
xiii.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD2信號傳導結構域及CD40信號傳導結構域。
xiv.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、GITR信號傳導結構域及CD40信號傳導結構域。
xv.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD29信號傳導結構域及CD40信號傳導結構域。
xvi.結合至CEA或MSLN之scFv、CD8之間隔體及跨膜序列、CD150信號傳導結構域及CD40信號傳導結構域。
xvii.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD28信號傳導結構域及CD40信號傳導結構域。
xviii.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體及CD40信號傳導結構域。
xix.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD137信號傳導結構域及CD40信號傳導結構域。
xx.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD134信號傳導結構域及CD40信號傳導結構域。
xxi.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD2信號傳導結構域及CD40信號傳導結構域。
xxii.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、GITR信號傳導結構域及CD40信號傳導結構域。
xxiii.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD29信號傳導結構域及CD40信號傳導結構域。
xxiv.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、CD150信號傳導結構域及CD40信號傳導結構域。
xxv.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、第一CD40信號傳導結構域及第二CD40信號傳導結構域。
xxvi.結合至CEA或MSLN之scFv、包括IgG4恆定區及CD28跨膜序列之間隔體、第一CD40信號傳導結構域及第二突變CD40信號傳導結構域。
xxvii.結合至CEA或MSLN之scFv、結合至PDL1之結合結構域、CD28之短間隔體及跨膜序列、CD28信號傳導結構域及CD40信號傳導結構域。
xxviii.結合至CEA或MSLN之scFv、結合至PDL1之結合結構域、CD28之短間隔體及跨膜序列以及CD40信號傳導結構域。
xxix.結合至CEA或MSLN之scFv、結合至CD155、CD112或CD113之結合結構域、CD28跨膜結構域、CD28信號傳導結構域及CD40信號傳導結構域。
xxx.結合至CD155、CD112或CD113之結合結構域、CD28跨膜結構域及CD40信號傳導結構域。
xxxi.結合至CEA或MSLN之scFv、結合至PDL1之結合結構域、CD28之短間隔體及跨膜序列、CD28信號傳導結構域及CD40信號傳導結構域。
xxxii.結合至CEA或MSLN之scFv、結合至PDL1之結合結構域、CD28之短間隔體及跨膜序列以及CD40信號傳導結構域。
xxxiii.結合至CEA或MSLN之scFv、結合至CD155、CD112或CD113之結合結構域、CD28之短間隔體及跨膜序列、CD28信號傳導結構域及CD40信號傳導結構域。
xxxiv.結合至CEA或MSLN之scFv、結合至CD155、CD112或CD113之結合結構域、CD28之短間隔體及跨膜序列以及CD40信號傳導結構域。
xxxv.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體以及NTRK1信號傳導結構域。
xxxvi.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、NTRK1信號傳導結構域及CD40信號傳導結構域。
xxxvii.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及NTRK1信號傳導結構域。
xxxviii.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域、NTRK1信號傳導結構域及CD40信號傳導結構域。
xxxix.結合至CEA或MSLN之scFv、包括ICOS細胞外結構域及ICOS跨膜序列之間隔體、ICOS信號傳導結構域及CD40信號傳導結構域。
xl.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及ICOS信號傳導結構域。
xli.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域、ICOS信號傳導結構域及CD40信號傳導結構域。
xlii.結合至CEA或MSLN之scFv、包括CD2細胞外結構域之間隔體及CD2跨膜序列、CD2信號傳導結構域及CD40信號傳導結構域。
xliii.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及CD2信號傳導結構域。
xliv.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域、CD40信號傳導結構域及CD2信號傳導結構域。
xlv.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及CD137信號傳導結構域。
xlvi.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域、CD40信號傳導結構域及CD137信號傳導結構域。
xlvii.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及DAP10信號傳導結構域。
xlviii.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域、CD40信號傳導結構域及DAP10信號傳導結構域。
xlix.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD28信號傳導結構域及CD134信號傳導結構域。
xlx.結合至CEA或MSLN之scFv、包括CD28細胞外結構域及CD28跨膜序列之間隔體、CD40信號傳導結構域及CD134信號傳導結構域。
在一些實施例中，CoStAR包括結合至MSLN之scFv，該scFv連接至段落i-xlx中之任一者之間隔體、跨膜結構域及信號傳導結構域結構。
在一些實施例中，CoStAR包括結合至FolR1之scFv，該scFv連接至段落i-xlx中之任一者之間隔體、跨膜結構域及信號傳導結構域結構。
在一些實施例中，CoStAR包括i-xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構，且藉由包括scFv MOV19 (SEQ ID NO:9)之抗原結合片段之結合結構域結合至FolR1或MSLN。
在一些實施例中，CoStAR包括i-xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv MFE23 (SEQ ID NO:10)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv MFE23(K＞Q) (SEQ ID NO:11)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括人類化scFv MFE23 (hMFE23) (SEQ ID NO:12)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv CEA6 (SEQ ID NO:13)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv BW431/26 (SEQ ID NO:14)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv HuT84.66(M5A) (SEQ ID NO:15)之抗原結合片段之結合結構域結合至CEA。
在一些實施例中，CoStAR包括i-xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv MOV19 (SEQ ID NO:9)之抗原結合片段之結合結構域結合至FolR1。
在一些實施例中，CoStAR包括i-xxxiv及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv SS1 (SEQ ID NO:186)之抗原結合片段之結合結構域結合至MSLN。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv M5 (人類化SS1) (SEQ ID NO:187)之抗原結合片段之結合結構域結合至MSLN。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括人類化scFv HN1 (SEQ ID NO:188)之抗原結合片段之結合結構域結合至MSLN。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv M912 (SEQ ID NO:189或SEQ ID NO:511)之抗原結合片段之結合結構域結合至MSLN。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv HuYP218 (SEQ ID NO:190或SEQ ID NO: 512)之抗原結合片段之結合結構域結合至MSLN。
在一些實施例中，CoStAR包括i-xxvi及xxxi至xxxiv中之任一者之間隔體、跨膜結構域及信號傳導結構域結構且藉由包括scFv P4 (SEQ ID NO:191或SEQ ID NO: 513)之抗原結合片段之結合結構域結合至MSLN。
如本文中所使用，術語「特異性結合」或「對……具有特異性」係指可量測且可再現之相互作用，例如靶與抗體或抗體部分間之結合，其決定了在異質分子群體(包含生物分子)存在下靶之存在。舉例而言，特異性結合靶(其可為表位)之抗體部分係與其結合其他靶相比以更大親和力、親合力更容易地及/或以更長持續時間結合該靶之抗體部分。在一些實施例中，特異性結合至抗原之抗體部分與抗原(例如細胞表面抗原或肽/MHC蛋白質複合物)之一或多種抗原決定子進行反應，其中結合親和力至少約10倍於其與其他靶之結合親和力。在一些實施例中，特異性結合表示至少10 6、10 7、10 8、10 9或10 10M -1之親和力。特異性結合之量級可檢測地高於與至少一種無關靶之非特異性結合且可與其區分。特異性結合可係源於在特定官能基或特定空間配合(例如鎖及鑰匙型)之間形成鍵，而非特異性結合通常係源於凡得瓦力(van der Waals force)。然而，特異性結合未必暗示抗體或融合蛋白結合一種且僅一種靶。
全長抗體結構單元係亞單元之四聚體。每一四聚體包含兩對相同多肽鏈，每一對具有一個「輕」鏈(約25 kDa)及一條「重」鏈(約50-70 kDa)。每一鏈之胺基末端部分包含主要負責抗原識別之約100個至110個或更多胺基酸的可變區。此可變區最初表現為連接至可裂解信號肽。不含信號肽之可變區有時稱為成熟可變區。因此，舉例而言，輕鏈成熟可變區意指不含輕鏈信號肽之輕鏈可變區。然而，在提及可變區時並不意指信號序列必然存在；且實際上在已表現及分泌抗體或融合蛋白後信號序列發生裂解。重鏈及輕鏈對可變區定義抗體之結合區。輕鏈及重鏈之羧基末端部分分別定義輕鏈及重鏈恆定區。
輕鏈分為κ或λ。重鏈分為γ、µ、α、δ或ε，且將抗體之同型分別定義為IgG、IgM、IgA、IgD及IgE。在輕鏈及重鏈內，可變區及恆定區通過具有約12個或更多胺基酸之「J」區段接合，且重鏈亦包含具有約10個或更多胺基酸之「D」區段。(通常參見Fundamental Immunology (Paul, W.編輯，第2版，Raven Press, N.Y., 1989), Ch. 7) (其全部內容出於所有目的以引用方式併入本文中)。
每一輕鏈/重鏈對之成熟可變區形成抗體結合位點。因此，完整抗體具有兩個結合位點，亦即為二價。在天然抗體中，結合位點相同。然而，可製備兩個結合位點不同之雙特異性抗體(例如參見Songsivilai S, Lachmann PC. 1990. Bispecific antibody: a tool for diagnosis and treatment of disease. Clin Exp Immunol. 79:315-321；Kostelny S A, Cole M S, Tso J Y. 1992. Formation of bispecific antibody by the use of leucine zippers. J Immunol. 148: 1547-1553)。可變區皆展現由三個超變區(亦稱為互補決定區或CDR)接合之相對保守框架區(FR)之相同通用結構。來自每一對之兩條鏈之CDR藉由框架區對齊，從而使得能夠結合至特定表位。輕鏈及重鏈皆自N末端至C末端包括結構域FR1、CDR1、FR2、CDR2、FR3、CDR3及FR4。為方便起見，可變重鏈CDR可稱為HCDR1、HCDR2及HCDR3；可變輕鏈CDR可稱為LCDR1、LCDR2及LCDR3。胺基酸在每一結構域中之指派係根據以下文獻中之定義：Kabat E A等人，1987 and 1991. Sequences of Proteins of Immunological Interest (National Institutes of Health, Bethesda, Md.)；或Chothia C, Lesk A M. 1987. Canonical Structures for the Hypervariable Regions of Immunoglobulins. J Mol Biol 196:901-917；Chothia C等人，1989. Conformations of Immunoglobulin Hypervariable Regions. Nature 342:877-883。Kabat亦提供廣泛使用之編號慣例(Kabat編號)，其中向不同重鏈可變區之間或不同輕鏈可變區之間之相應殘基指派相同編號。儘管Kabat編號可用於抗體恆定區，但亦可使用EU編號。
術語「 表位 」係指抗原中抗體所結合之位點。蛋白質上之表位可自鄰接胺基酸或由一或多種蛋白質之三級摺疊並置之非鄰接胺基酸形成。
如本文所述，CoStAR之結合係經由可包含抗體或其結合片段之結合結構域來達成。結合片段之實例包含Fv、Fab'、Fab'-SH、F(ab')2；二價抗體；線性抗體；單鏈抗體分子(例如scFv)；及自抗體片段形成之多特異性抗體。scFv抗體闡述於Houston J S. 1991. Methods in Enzymol. 203:46-96中。另外，抗體片段包括單鏈多肽，其具有VH結構域之特性，即能夠與VL結構域一起組裝成功能性抗原結合位點；或具有VL結構域之特性，即能夠與VH結構域一起組裝成功能性抗原結合位點，且由此提供全長抗體之抗原結合性質。 間隔體
在一些實施例中，CoStAR視情況在抗原結合結構域與共刺激受體之間包括間隔體區。如本文中所使用，術語「間隔體」係指CoStAR中分隔抗原結合結構域與共刺激蛋白之外部配體結合結構域之細胞外結構區。間隔體使得可靈活接近標靶抗原及受體配體。在一些實施例中，採用長間隔體以(例如)靶向膜近端表位或醣基化抗原(參見Guest R.D.等人，The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens. J. Immunother. 2005;28:203-211；Wilkie S.等人，Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor. J. Immunol. 2008;180:4901-4909)。在其他實施例中，CoStAR具有短間隔體以(例如)靶向膜遠端表位(參見Hudecek M.等人，Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells. Clin. Cancer Res. 2013;19:3153-3164；Hudecek M.等人，The nonsignalling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity. Cancer Immunol. Res. 2015;3:125-135)。在一些實施例中，間隔體包括IgG鉸鏈(包含(但不限於) IgG1、IgG2或IgG4)之全部或一部分或自其衍生。「衍生自Ig鉸鏈」意指間隔體包括IgG鉸鏈中之插入、缺失或突變。在一些實施例中，間隔體可包括一或多個抗體恆定結構域(例如(但不限於) CH2及/或CH3結構域)之全部或一部分。在一些實施例中，在包括CH2結構域之全部或一部分之間隔體中，CH2結構域經修飾以不結合至Fc受體。舉例而言，已發現，骨髓樣細胞中之Fc受體結合會損害CAR T細胞功能性。在一些實施例中，間隔體包括來自CD28、CD8或包括鉸鏈區之其他蛋白質之Ig樣鉸鏈之全部或一部分。在一些實施例中，CoStAR包括間隔體，間隔體長度之為1至50個胺基酸。
在一非限制性實施例中，間隔體包括基本上所有之細胞外結構域，例如CD28細胞外結構域(亦即約胺基酸19、20、21或22至約胺基酸152)或另一蛋白質(包含(但不限於)另一TNFR超家族成員)之細胞外結構域。在一實施例中，間隔體包括細胞外結構域之一部分(例如CD28細胞外結構域之一部分)，且可缺乏Ig結構域之全部或大部分。在另一實施例中，間隔體包含CD28之約141至約152之胺基酸，但不包含CD28細胞外結構域之其他部分。在另一實施例中，間隔體包含CD8之約128至約182之胺基酸，但不包含CD8細胞外結構域之其他部分。
在一些實施例中，抗MSLN CoStAR中之間隔體係CD28間隔體結構域、截短CD28間隔體結構域或CD8間隔體結構域。在一些實施例中，改變間隔體結構域可增加在識別信號1及信號2時T細胞效應細胞介素之分泌。在一些實施例中，T細胞效應細胞介素係IL-2、IFNγ及TNFα。 連接體
在一些實施例中，CoStAR細胞外結構域包括連接體。連接體包括用於連結結構域(例如具有間隔體之結合結構域或跨膜結構域)之短胺基酸片段。為靈活地結合配體，配體結合結構域通常藉由包括約5至25個胺基酸之撓性連接體(例如AAAGSGGSG (SEQ ID NO:18)、GGGGSGGGGSGGGGS (SEQ ID NO:431))連結至間隔體或跨膜結構域。在一些實施例中，CoStAR包括結合藉由連接體且不使用間隔體直接接合至跨膜結構域之結構域。在一些實施例中，CoStAR包括藉由間隔體且不使用連接體直接接合至跨膜結構域之結合結構域。 信號傳導結構域
如上文所論述，在一些實施例中，CoStAR包括全長一級共刺激受體，該受體可包括(但不限於) CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之細胞外配體結合及細胞內信號傳導部分。在其他實施例中，共刺激受體包括(例如)包括一種上文所提及蛋白質之細胞外配體結合結構域及另一上文所提及蛋白質之細胞內信號傳導結構域之嵌合蛋白。在一些實施例中，CoStAR之信號傳導部分包括單一信號傳導結構域。在其他實施例中，CoStAR之信號傳導部分包括第二細胞內信號傳導結構域，例如(但不限於)：CD2、CD27、CD28、CD40、CD134 (OX40)、CD137 (4-1BB)、CD150 (SLAM)。在一些實施例中，第一及第二細胞內信號傳導結構域係相同的。在其他實施例中，第一及第二細胞內信號傳導結構域係不同的。在一些實施例中，共刺激受體能夠發生二聚合。不受限於理論，據信，CoStAR與用於信號引發之其他輔助分子進行二聚合或締合。在一些實施例中，CoStAR與輔助分子經由跨膜結構域相互作用進行二聚合或締合。在一些實施例中，與輔助分子之二聚合或締合係藉由共刺激受體之細胞內部分及/或細胞外部分中之共刺激受體相互作用來輔助。 跨膜結構域
儘管跨膜結構域之主要功能係將CoStAR錨定於T細胞膜中，但在一些實施例中，跨膜結構域會影響CoStAR功能。在一些實施例中，跨膜結構域由全長一級共刺激受體結構域構成。在實施例中，CoStAR構築包括一種受體之細胞外結構域及第二受體之細胞內信號傳導結構域，跨膜結構域可為細胞外結構域或細胞內結構域之跨膜結構域。在一些實施例中，跨膜結構域係來自CD4、CD8α、CD28或ICOS。Gueden等人將ICOS跨膜結構域之使用與CAR T細胞持久性及整體抗腫瘤效能之增加聯繫起來(Guedan S.等人，Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI Insight. 2018;3:96976)。在一實施例中，跨膜結構域包括跨越細胞膜之疏水性α螺旋。
在一實施例中，跨膜結構域包括CD28跨膜結構域之約胺基酸153至約胺基酸179之胺基酸。在另一實施例中，跨膜結構域包括CD8跨膜結構域之約胺基酸183至約胺基酸203之胺基酸。在一些實施例中，CoStAR可在跨膜結構域與信號傳導結構域之間包含若干胺基酸。舉例而言，在本文所闡述之一種構築體中，自CD8跨膜結構域至信號傳導結構域之連接體包括CD8細胞質結構域之若干胺基酸(例如CD8之胺基酸204-210)。 變體
在一些實施例中，考慮本文所提供抗體部分或其他部分之胺基酸序列變體。舉例而言，可能期望改良抗體部分之結合親和力及/或其他生物性質。抗體部分之胺基酸序列變體可藉由將適宜修飾引入編碼抗體部分之核苷酸序列中或藉由肽合成來製備。該等修飾包含(例如)抗體部分之胺基酸序列內殘基之缺失及/或插入及/或取代。可實施缺失、插入及取代之任何組合以獲得最終構築體，條件係最終構築體具有期望特性(例如抗原結合性)。
在一些實施例中，提供包括一或多個胺基酸取代、缺失或插入之抗體結合結構域部分。用於突變變化之所關注位點包含抗體結合結構域之重鏈及輕鏈可變區(VR)及框架(FR)。可將胺基酸取代引入所關注結合結構域中及針對期望活性(例如保持/改良抗原結合、降低免疫原性)篩選之產物中。在一些實施例中，可將胺基酸取代引入一級共刺激受體結構域(細胞外或細胞內)、二級共刺激受體結構域或細胞外共受體結構域中之一或多者中。因此，一些實施例涵蓋CoStAR及/或融合蛋白及本文特定揭示之組成部分以及其變體，亦即與本文特定揭示之胺基酸序列具有至少75%、至少80%、至少85%、至少87%、至少90%、至少91%、至少92%、至少93%、至少94%、至少95%、至少96%、至少97%、至少98%、至少99%序列一致性之CoStAR及/或融合蛋白及組成部分。在提及特定序列時，術語「類似性百分比」、「一致性百分比」及「同源性百分比」係如University of Wisconsin GCG軟體程式BestFit中所陳述來使用。可使用其他演算法，例如BLAST、psiBLAST或TBLASTN (其使用Altschul等人，(1990) J. Mol. Biol. 215: 405-410之方法)、FASTA (其使用Pearson及Lipman (1988) PNAS USA 85: 2444-2448之方法)。
特定胺基酸序列變體可與參考序列因插入、添加、取代或缺失1個胺基酸、2、3、4、5-10、10-20或20-30個胺基酸而不同。在一些實施例中，變體序列可包括插入、缺失或取代1、2、3、4、5、6、7、8、9、10個或更多個殘基之參考序列。舉例而言，可插入、缺失或取代5、10、15、最多20、最多30或最多40個殘基。
在一些較佳實施例中，變體可與參考序列因1、2、3、4、5、6、7、8、9、10個或更多個保守取代而不同。保守取代涉及使用具有類似性質之不同胺基酸代替某一胺基酸。舉例而言，脂肪族殘基可由另一脂肪族殘基代替，非極性殘基可由另一非極性殘基代替，酸性殘基可由另一酸性殘基代替，鹼性殘基可由另一鹼性殘基代替，極性殘基可由另一極性殘基代替，或芳香族殘基可由另一芳香族殘基代替。保守取代可(例如)發生於下列群組內之胺基酸之間：
保守取代展示於下表6中。
表6 -胺基酸取代
原始殘基 實例性取代 較佳取代
Ala (A) Val；Leu；Ile Val
Arg (R) Lys；Gln；Asn Lys
Asn (N) Gln；His；Asp；Lys；Arg Gln
Asp (D) Glu；Asn Glu
Cys (C) Ser；Ala Ser
Gln (Q) Asn；Glu Asn
Glu (E) Asp；Gln Asp
Gly (G) Ala Ala
His (H) Asn；Gln；Lys；Arg Arg
Ile (I) Leu；Val；Met；Ala；Phe；正白胺酸 Leu
Leu (L) 正白胺酸；Ile；Val；Met；Ala；Phe Ile
Lys (K) Arg；Gln；Asn Arg
Met (M) Leu；Phe；Ile Leu
Phe (F) Trp；Leu；Val；Ile；Ala；Tyr Tyr
Pro (P) Ala Ala
Ser (S) Thr Thr
Thr (T) Val；Ser Ser
Trp (W) Tyr；Phe Tyr
Tyr (Y) Trp；Phe；Thr；Ser Phe
Val (V) Ile；Leu；Met；Phe；Ala；正白胺酸 Leu
胺基酸可根據常見側鏈性質分成以下不同種類：a.疏水性：正白胺酸、Met、Ala、Val、Leu、Ile；b.中性親水性：Cys、Ser、Thr、Asn、Gln；c.酸性：Asp、Glu；d.鹼性：His、Lys、Arg；e.影響鏈定向之殘基：Gly、Pro；芳香族：Trp、Tyr、Phe。非保守性取代使得需要將該等種類之一種之成員與另一種類交換。 細胞
細胞可為可用於過繼細胞療法中之任何淋巴球，例如T細胞或天然殺手(NK)細胞、NKT細胞、γ/δ T細胞或T調控細胞。細胞針對患者可為同種異體或自體的。
T細胞或T淋巴球係一類在細胞介導之免疫性中具有核心作用之淋巴球。其與其他淋巴球(例如B細胞及天然殺手細胞(NK細胞))之區別可在於在細胞表面上存在T細胞受體(TCR)。存在各種類型之T細胞，如下文所匯總。細胞毒性T細胞(TC細胞或CTL)會破壞病毒感染性細胞及腫瘤細胞，且亦參與移植排斥。CTL在其表面上表現CD8分子。
該等細胞藉由結合至與MHC I類締合之抗原(其存在於所有有核細胞之表面上)來識別其靶。經由IL-10、腺苷及由調控性T細胞分泌之其他分子，CD8+細胞可不活化至無反應性狀態，此會預防自體免疫疾病(例如實驗自體免疫腦脊髓炎)。
記憶性T細胞係在感染已消退之後長期持續存在之抗原特異性T細胞之子組。其在再暴露於其同族抗原時迅速擴增至大量效應性T細胞，由此提供具有針對既往感染之「記憶」之免疫系統。記憶性T細胞包括以下三種亞型：中央記憶性T細胞(TCM細胞)及兩類效應記憶性T細胞(TEM細胞及TEMRA細胞)。記憶細胞可為CD4+或CD8+。記憶性T細胞通常表現細胞表面蛋白CD45RO。調控性T細胞(Treg細胞，先前稱為抑制性T細胞)對於維持免疫耐受性至關重要。其主要作用係在免疫反應結束時停止T細胞介導之免疫性且抑制逃脫胸腺中之負向選擇過程之自體反應性T細胞。
已闡述以下兩大類CD4+ Treg細胞-天然Treg細胞及適應性Treg細胞。天然Treg細胞(亦稱為CD4 +CD25 +FoxP3 +Treg細胞)出現於胸腺中，且同發育中T細胞與已經TSLP活化之骨髓樣(CD11c +)及漿細胞樣(CD123 +)樹突狀細胞之間之相互作用有關。天然Treg細胞與其他T細胞之區別可在於存在稱為FoxP3之細胞內分子。適應性Treg細胞(亦稱為Tr1細胞或Th3細胞)可源於正常免疫反應期間。
天然殺手細胞(或NK細胞)係一類形成先天性免疫系統之一部分之溶細胞。NK細胞以MHC獨立方式對來自病毒感染性細胞之先天性信號提供快速反應。NK細胞(屬先天性淋巴樣細胞之群組)可定義為大顆粒淋巴球(LGL)，且構成自生成B及T淋巴球之公共淋巴樣祖細胞分化之第三種細胞。
在一些實施例中，治療細胞包括經改造以表現CoStAR之自體細胞。在一些實施例中，治療細胞包括經改造以表現CoStAR之同種異體細胞。表現CoStAR之自體細胞可有利於避免由TCR介導之接受同種異體抗原識別所致之移植物抗宿主病(GVHD)。同樣，CoStAR接受者之免疫系統可攻擊所輸注CoStAR細胞，從而引起排斥。在某些實施例中，為預防GVHD並減小排斥，藉由基因體編輯自同種異體CoStAR細胞去除內源TcR。 核酸
在一些實施例中，提供編碼本文所闡述之任一CoStAR、多肽或蛋白質(包含其功能部分及功能變體)之核酸序列。如本文中所使用，術語「多核苷酸」、「核苷酸」及「核酸」意欲彼此同義。熟習此項技術者應理解，因基因代碼之簡並性，諸多不同之多核苷酸及核酸可編碼相同多肽。另外，應理解，熟習此項技術者可使用常規技術來進行不影響由本文所闡述多核苷酸編碼之多肽序列之核苷酸取代，從而反映擬表現多肽之任何特定宿主生物體中之密碼子使用(例如密碼子最佳化)。核酸可包括DNA或RNA。其可為單鏈或雙鏈。其亦可為其內包含合成或經修飾核苷酸之多核苷酸。業內已知諸多不同類型之寡核苷酸修飾。該等修飾包含甲基膦酸酯及硫代磷酸酯骨架、在分子之3'及/或5'端處添加吖啶或聚離胺酸鏈。出於本發明目的，應理解，可藉由業內可用之任何方法來修飾多核苷酸。可實施該等修飾以增強所關注多核苷酸之活體內活性或壽命。
關於核苷酸序列之術語「變體」、「同系物」或「衍生物」包含序列之一個(或多個)核酸之任何取代、變化、修飾、代替、缺失或添加。
核酸序列可編碼CoStAR及/或融合蛋白，包含(但不限於) SEQ ID NO:42-247或SEQ ID NO:196-335中之任一者或其變體。核苷酸序列可包括所展示經改造以表現於人類細胞中之密碼子最佳化之核酸序列。
提供包括編碼CoStAR之一個核酸序列及編碼T細胞受體(TCR)及/或嵌合抗原受體(CAR)之另一核酸序列之核酸序列。
核酸序列可藉由容許共表現兩個或更多個核酸序列之序列接合。舉例而言，構築體可包括內部啟動子、內部核糖體進入序列(IRES)序列或編碼裂解位點之序列。裂解位點可自裂解，從而在產生多肽時，其立即裂解成離散蛋白而無需任何外部裂解活性。已知各種自裂解位點，包含口蹄疫病毒(FMDV)及2A自裂解肽。共表現序列可為內部核糖體進入序列(IRES)。共表現序列可為內部啟動子。 載體
在一些實施例中，提供包括核酸序列或核酸之載體。
可使用此一載體將核酸序列或核酸構築體引入宿主細胞中，從而宿主細胞表現本發明第一態樣之一或多種CoStAR及視情況一或多種其他所關注蛋白質(POI) (例如TCR或CAR)。載體可為(例如)質體或病毒載體(例如逆轉錄病毒載體或慢病毒載體)或基於轉位子之載體或合成mRNA。
本發明核酸亦可利用標準基因遞送方案用於核酸免疫及基因療法。用於基因遞送之方法為業內已知。例如參見美國專利第5,399,346號、第5,580,859號、第5,589,466號，該等專利之全部內容皆以引用方式併入本文中。
源自逆轉錄病毒(例如慢病毒)之載體係達成長期基因轉移之適宜工具，此乃因其容許一或多種轉基因長期穩定整合並在子細胞中繁殖。載體可能能夠轉染或轉導淋巴球(包含T細胞或NK細胞)。亦提供插入如本文所提供之核酸之載體。通常藉由以下方式來達成編碼CoStAR及視情況TCR或CAR之天然或合成核酸之表現：使編碼CoStAR及TCR/CAR多肽或其部分之核酸可操作地連接至一或多個啟動子，並將構築體納入表現載體中。
其他啟動子元件(例如增強子)調控轉錄起始之頻率。通常，該等元件位於起始位點上游之30-110 bp區域中，但最近已證實多種啟動子亦含有位於起始位點下游之功能元件。啟動子元件之間之間距通常較靈活，從而在相對於彼此插入或移動元件時保留啟動子功能。在胸苷激酶(tk)啟動子中，啟動子元件之間之間距可在活性開始下降之前增加至50 bp。
適宜啟動子之一實例係立即早期巨細胞病毒(CMV)啟動子序列。此啟動子序列係能夠驅動與其操作性連接之任何多核苷酸序列之高表現含量的強組成型啟動子序列。適宜啟動子之另一實例係延伸生長因子-1α (EF-1α)。然而，亦可使用其他組成型啟動子序列，包含(但不限於)猿猴病毒40 (SV40)早期啟動子、小鼠乳房腫瘤病毒(MMTV)、人類免疫缺陷病毒(HIV)長末端重複序列(LTR)啟動子、MoMuLV啟動子、MSCV啟動子、MND啟動子、禽類白血病病毒啟動子、愛潑斯坦-巴爾病毒(Epstein-Barr virus)立即早期啟動子、勞斯肉瘤病毒(Rous sarcoma virus)啟動子以及人類基因啟動子(例如(但不限於)肌動蛋白啟動子、肌凝蛋白啟動子、血紅素啟動子及肌酸激酶啟動子)。
載體可適於在真核細胞中複製及整合。典型選殖載體含有轉錄及轉譯終止子、起始序列及可用於調控期望核酸序列表現之啟動子。病毒載體技術在業內已眾所周知且闡述於(例如) Sambrook等人，(2001, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, New York)及其他病毒學及分子生物學手冊中，亦參見WO 01/96584、WO 01/29058及美國專利第6,326,193號。在一些實施例中，所表現構築體係如SEQ ID NO:42-247或196-335、362-363、369-420及514中所展示。在一些實施例中，核酸係允許在單一啟動子之控制下表現多種轉基因(例如CoStAR及TCR及/或CAR等)之多順反子構築體。在一些實施例中，藉由自裂解2A肽來分隔轉基因(例如CoStAR及TCR及/或CAR等)。可用於核酸構築體之2A肽實例包含F2A、P2A、T2A及E2A。在其他實施例中，核酸構築體係包括以下兩種啟動子之多順反子構築體：一種啟動子驅動CoStAR之表現且另一啟動子驅動TCR或CAR之表現。在一些實施例中，雙啟動子構築體係單向的。在一些實施例中，雙啟動子構築體係雙向的。為評價CoStAR多肽或其部分之表現，擬引入細胞中之表現載體亦可含有可選標記基因或報告基因或二者以有利於自試圖經由病毒載體轉染或轉導之細胞群體鑑別及選擇表現細胞。 細胞來源
在擴增及基因修飾之前，自個體獲得細胞來源(例如免疫效應細胞，例如T細胞或NK細胞)。術語「個體」意欲包含可誘發免疫反應之活生物體(例如哺乳動物)。個體之實例包含人類、狗、貓、小鼠、大鼠及其轉基因物種。T細胞可自多種來源獲得，該等來源包含外周血單核細胞、骨髓、淋巴結組織、臍帶血、胸腺組織、來自感染部位之組織、腹水、胸膜滲出液、脾組織及腫瘤。
在一態樣中，藉由溶解紅血球且清除單核球自外周血淋巴球分離T細胞，例如藉由PERCOLLTM梯度離心或藉由逆流離心淘析來分離。可在血球分離中心及細胞儲存設施處收集T細胞，可在此處收穫T細胞，維持，並輕鬆轉移。可冷凍保存T細胞並儲存以供後用。可確定並驗證可接受之儲存持續時間，且其可為最長6個月、最長一年或更長。
在另一態樣中，自腫瘤(例如自經片段化、解剖或酶消解之腫瘤生檢或腫塊)分離腫瘤浸潤細胞(TIL)且/或擴增。可以下兩階段製程使用腫瘤生檢作為起始材料來產生TIL：階段1 (通常實施於2-3小時內)-首先收集腫瘤材料並使用解剖、酶促消解及均質化進行處理以產生單細胞懸浮液，可將其直接冷凍保存以穩定起始材料，從而用於後續製造及階段2 (其可發生於數天或數年後)。階段2可實施於4週內，其可為以下連續過程：自將階段1之產物解凍並自腫瘤起始材料生長TIL (約2週)開始，隨後對TIL細胞實施快速擴增製程(約2週)以增加細胞量且由此增加劑量。可濃縮TIL並洗滌，然後調配為液體細胞懸浮液。
可在收集後之任何時刻下轉導TIL群體。在一些實施例中，在解凍後，轉導經冷凍保存之TIL群體以表現CoStAR。在一些實施例中，在自腫瘤起始材料長出或初始擴增期間，轉導TIL群體以表現CoStAR。在一些實施例中，在REP期間(例如(但不限於) REP之約第8天至約第10天)，轉導TIL群體以表現CoStAR。一實例性TIL製備闡述於申請者在2019年12月20日提出申請之美國專利申請案第62/951,559號中。
可藉由正向或負向選擇技術進一步分離T細胞之特定亞群，例如CD3+、CD28+、CD4+、CD8+、CD45RA+及CD45RO+T細胞。舉例而言，在一態樣中，T細胞係藉由與抗CD3/抗CD28偶聯之珠粒(例如DYNABEADS® M-450 CD3/CD28 T)一起培育足以對期望T細胞進行正向選擇之時間段來分離。在一態樣中，時間段為約30分鐘。在又一態樣中，時間段介於30分鐘至36小時之間或更長及為其間之所有整數值。在又一態樣中，時間段係至少1、2、3、4、5或6小時。在又一較佳態樣中，時間段為10小時至24小時。在一態樣中，培育時間段為24小時。在與其他細胞類型相比T細胞極少的任何情況下(例如在自腫瘤組織或自免疫受損個體分離腫瘤浸潤淋巴球(TIL)中)，可利用較長培育時間來分離T細胞。另外，利用較長培育時間可增加捕獲CD8+ T細胞之效率。因此，藉由簡單地縮短或延長時間可使T細胞與CD3/CD28珠粒結合，及/或藉由增加或減小珠粒對T細胞之比率(如本文進一步所述)，可在培養起始時或該過程期間之其他時間點優先選擇或不選擇T細胞亞群。另外，藉由增加或減少珠粒或其他表面上之抗CD3及/或抗CD28抗體之比率，可在培養起始時或其他期望時間點優先選擇或不選擇T細胞亞群。熟習此項技術者將意識到亦可在本發明背景下使用多輪選擇。在某些態樣中，可期望在活化及擴增過程中實施選擇程序且使用「未經選擇之」細胞。亦可使「未經選擇之」細胞經歷多輪選擇。
藉助負向選擇之T細胞群之富集可使用針對負向選擇細胞所獨有之表面標記之抗體的組合來完成。一種方法係經由負磁免疫黏附或流式細胞術使用針對存在於負向選擇細胞上之細胞表面標記物之單株抗體的混合物之細胞分選及/或選擇。舉例而言，為藉由負向選擇富集CD4+細胞，單株抗體混合物通常包含針對CD14、CD20、CD16、HLA-DR及CD8之抗體。在某些態樣中，可期望富集或正向選擇通常表現CD4+、CD25+、CD62Lhi、GITR+、CD137、PD1、TIM3、LAG-3、CD150及FoxP3+之調控性T細胞。或者，在某些態樣中，T調控細胞係藉由抗CD25偶聯珠粒或其他相似選擇方法來清除。
本文所闡述之方法可包含(例如)使用(例如)負向選擇技術(例如本文所闡述)選擇為T調控細胞耗乏群體之特定免疫效應細胞(例如T細胞)亞群CD25+耗乏細胞。較佳地，T調控性耗乏細胞之群體含有小於30%、25%、20%、15%、10%、5%、4%、3%、2%、1%之CD25+細胞。
可藉由正向選擇技術來富集特異性結合至靶抗原之CoStAR效應細胞之特定亞群體。舉例而言，在一些實施例中，藉由與靶抗原偶聯珠粒培育足以正向選擇期望abTCR效應細胞之時間段來富集效應細胞。在一些實施例中，時間段為約30分鐘。在一些實施例中，時間段介於30分鐘至36小時之間或更長(包含該等值之間之所有範圍)。在一些實施例中，時間段係至少1、2、3、4、5或6小時。在一些實施例中，時間段為10小時至24小時。在一些實施例中，培育時間段為24小時。為分離以低含量存在於異質細胞群體中之效應細胞，使用較長培育時間(例如24小時)可增加細胞產率。在效應細胞少於其他細胞類型之任何情況下，可使用較長培育時間來分離效應細胞。熟習此項技術者將意識到亦可在本發明背景下使用多輪選擇。
亦可在洗滌步驟之後冷凍用於刺激之T細胞。在去除血漿及血小板之洗滌步驟之後，可將細胞懸浮於冷凍溶液中。儘管許多冷凍溶液及參數為業內已知且可用於此背景下，但一種方法涉及利用含有20% DMSO及8%人類血清白蛋白之PBS，或含有10%葡聚糖40及5%右旋糖、20%人類血清白蛋白及7.5% DMSO或31.25% Plasmalyte-A、31.25%右旋糖5%、0.45% NaCl、10%葡聚糖40及5%右旋糖、20%人類血清白蛋白及7.5% DMSO之培養基或其他含有(例如)羥乙基澱粉及PlasmaLyte A之適宜細胞冷凍培養基，然後以1°/分鐘之速率將細胞冷凍至-80℃且儲存在液氮儲存罐之氣相中。可使用其他受控冷凍方法以及立即在-20℃下或液氮中之不受控冷凍。 同種異體CoStAR
在本文所闡述之實施例中，免疫效應細胞可為同種異體免疫效應細胞，例如T細胞或NK細胞。舉例而言，細胞可為同種異體T細胞，例如缺乏內源T細胞受體(TCR)及/或人類白血球抗原(HLA) (例如I類HLA及/或II類HLA)表現之同種異體T細胞。
缺乏功能性內源TCRT之細胞可(例如)經改造以便其在其表面上不表現任何功能性TCR，經改造以便其不表現一或多個包括功能性TCR之亞單元(例如經改造以便其不表現(或展現較低表現) TCR α、TCR β、TCR γ、TCR δ、TCRε及/或TCR ζ)，或經改造以便其在其表面上產生極少功能性TCR。或者，T細胞可(例如)藉由表現TCR之一或多個亞單元之突變或截短形式來表現實質上受損之TCR。術語「實質上受損之TCR」意指此TCR不會引發宿主中之不利免疫反應。
本文所闡述之T細胞可(例如)經改造以便其在其表面上不表現功能性HLA。舉例而言，本文所闡述之T細胞可經改造以便下調細胞表面表現之HLA，例如I類HLA及/或II類HLA。在一些態樣中，可藉由減小或消除β- 2微球蛋白(B2M)之表現來下調HLA。
在一些實施例中，T細胞可缺乏功能性TCR及功能性HLA，例如I類HLA及/或II類HLA。缺乏功能性TCR及/或HLA之表現之經修飾T細胞可藉由任何適宜方式(包含敲除或敲低TCR或HLA之一或多個亞單元)來獲得。舉例而言，T細胞可包含利用siRNA、shRNA、成簇規律間隔之短回文重複(CRISPR)轉錄活化因子樣效應核酸酶(TALEN)或鋅指核酸內切酶(ZFN)之TCR及/或HLA敲低。
在一些實施例中，同種異體細胞可為不表現或表現少量抑制分子之細胞，例如藉由本文所闡述之任何方法改造之細胞。舉例而言，細胞可為不表現或表現少量(例如)可降低CoStAR表現細胞引起免疫效應反應之能力之抑制分子的細胞。抑制分子之實例包含PD1、PD-L1、PD-L2、CTLA4、TIM3、CEACAM (例如CEACAM-1、CEACAM-3及/或CEACAM-5)、LAG3、VISTA、BTLA、TIGIT、LAIR1、CD160、2B4、CD80、CD86、B7-H3 (CD276)、B7-H4 (VTCN1)、HVEM (TNFRSF14或CD270)、KIR、A2aR、I類MHC、II類MHC、Gal9、腺苷及TGFR β。抑制分子之抑制(例如藉由在DNA、RNA或蛋白質層面上抑制)可最佳化CAR表現細胞性能。在實施例中，可使用抑制核酸，例如如本文所闡述之抑制核酸，例如dsRNA、例如siRNA或shRNA、成簇規律間隔之短回文重複(CRISPR)、轉錄活化因子樣效應核酸酶(TALEN)或鋅指核酸內切酶(ZFN)。 使用siRNA或shRNA抑制內源TCR或HLA
在一些實施例中，可使用靶向編碼T細胞中之TCR及/或HLA及/或本文所闡述之抑制分子(例如PD1、PD-L1、PD-L2、CTLA4、TIM3、CEACAM (例如CEACAM-1、CEACAM-3及/或CEACAM-5)、LAG3、VISTA、BTLA、TIGIT、LAIR1、CD160、2B4、CD80、CD86、B7-H3 (CD276)、B7-H4 (VTCN1)、HVEM (TNFRSF14或CD270)、KIR、A2aR、I類MHC、II類MHC、Gal9、腺苷及TGFR β)之核酸之siRNA或shRNA來抑制TCR表現及/或HLA表現。
siRNA及shRNA在T細胞中之表現可利用任何習用表現系統(例如慢病毒表現系統)來達成。下調TCR組分之表現之實例性shRNA闡述於(例如)美國公開案第2012/0321667號中。下調I類HLA及/或II類HLA基因之表現之實例性siRNA及shRNA闡述於(例如)美國公開案第US 2007/0036773號中。 抑制TCR或HLA之CRISPR
本文所用之「CRISPR」或「抑制TCR及/或HLA之CRISPR」係指成簇規律間隔之短回文重複之集合或包括此一重複集合之系統。本文所用之「Cas」係指與CRISPR締合之蛋白質。「CRISPR/Cas」系統係指衍生自CRISPR及Cas之系統，其可用於沉默或突變TCR及/或HLA基因及/或本文所闡述之抑制分子(例如PD1、PD-L1、PD-L2、CTLA4、TIM3、CEACAM (例如CEACAM-1、CEACAM-3及/或CEACAM-5)、LAG3、VISTA、BTLA、TIGIT、LAIR1、CD160、2B4、CD80、CD86、B7-H3 (CD276)、B7-H4 (VTCNl)、HVEM (TNFRSF14或CD270)、KIR、A2aR、I類MHC、II類MHC、GAL9、腺苷及TGFR β)。
天然CRISPR/Cas系統發現於約40%之經定序真細菌基因體及90%之經定序古細菌中。Grissa等人，(2007) BMC Bioinformatics 8: 172。此系統係賦予外源遺傳元件(例如質體及噬菌體)抗性且提供獲得性免疫性形式之原核免疫系統類型。Barrangou等人，(2007) Science 315: 1709-1712；Marragini等人，( 2008) Science 322: 1843-1845。
在一些實施例中，融合蛋白或CoSTaR包括SEQ ID NO: 192、210、228、246、264、282及/或SEQ ID NO: 348中之任一者之多肽，其中該等序列展示於 表 7中。在一些實施例中，此結構包含SEQ ID NO: 192、210、228、246、264、282之某一部分及/或SEQ ID NO: 348之一些部分及/或其變體。在一些實施例中，融合蛋白或CoSTaR包括提供於圖83中之CEA構築體組分(全部或一部分或其變體)。在一些實施例中，融合蛋白或CoSTaR包括提供於圖84中之MSLN構築體組分(全部或一部分或其變體)。在一些實施例中，此結構包含SEQ ID NO: 83 (全部或一部分或其變體)。在一些實施例中，此結構包含SEQ ID NO: 84 (全部或一部分或其變體)。在一些實施例中，融合蛋白或CoStAR與如 表 7中所展示相同，且具有針對MSLN或CEA之結合結構域(例如scFv)。
在一些實施例中，癌症特異性CAR或TCR存在於含有融合蛋白或CoStAR之細胞中。在一些實施例中，融合蛋白或CoStAR可在啟動子之控制下單獨表現於具有治療活性之治療細胞群體(例如腫瘤浸潤淋巴球(TIL))中。在一些實施例中，融合蛋白或CoStAR可與治療轉基因(例如嵌合抗原受體(CAR)及/或T細胞受體(TCR))一起表現。
在一些實施例中，適宜TCR及CAR可為文獻中所熟知者，例如已成功地分別用於治療骨髓瘤或B細胞惡性腫瘤之HLA-A*02-NYESO-1特異性TCR (Rapoport等人，Nat Med 2015)或抗CD19scFv.CD3z融合CAR (Kochenderfer等人，J Clin Oncol 2015)。在一些實施例中，本文所闡述之CoStAR可與任何已知CAR或TCR一起表現，由此向細胞提供可調控生長開關以容許活體外或活體內細胞擴增並提供以TCR或CAR形式達成抗癌活性之習用活化機制。在一些實施例中，提供用於過繼細胞療法中之細胞，其包括如本文所闡述之CoStAR及特異性結合至腫瘤相關抗原之TCR及/或CAR。在一些實施例中，包括CD28之實例性CoStAR包含細胞外抗原結合結構域及細胞外、跨膜及細胞內信號傳導結構域。 T細胞之活化及擴增
T細胞通常可利用如(例如)以下專利中所闡述之方法來活化及擴增：美國專利第6,352,694號；第6,534,055號；第6,905,680號；第6,692,964號；第5,858,358號；第6,887,466號；第6,905,681號；第7,144,575號；第7,067,318號；第7,172,869號；第7,232,566號；第7,175,843號；第5,883,223號；第6,905,874號；第6,797,514號；第6,867,041號；及美國專利申請公開案第20060121005號。
通常，T細胞可藉由與表面接觸來擴增，該表面具有附接至其之刺激CD3/TCR複合物相關信號之試劑及刺激T細胞表面上之共刺激分子之配體。特定而言，T細胞群體可如本文所闡述來刺激，例如藉由與固定在表面上之抗CD3抗體或其抗原結合片段或抗CD2抗體接觸，或藉由與蛋白激酶C活化劑(例如苔蘚蟲素)以及鈣離子載體接觸來刺激。對於T細胞表面上輔助分子之共刺激而言，使用結合輔助分子之配體。舉例而言，可在適於刺激T細胞增殖之條件下使T細胞群體與抗CD3抗體及抗CD28抗體接觸。為刺激CD4+ T細胞或CD8+ T細胞之增殖，可使用抗CD3抗體及抗CD28抗體。抗CD28抗體之實例包含9.3、B-T3、XR-CD28 (Diaclone, Besancon, France)，可使用業內通常已知之其他方法(Berg等人，Transplant Proc. 30(8):3975-3977, 1998；Haanen等人，J. Exp. Med. 190(9):13191328, 1999；Garland等人，J. Immunol Meth. 227(l-2):53-63, 1999)。
在一些實施例中，可使用熟習此項技術者已知之燒瓶或容器或透氣容器來實施擴增且可進行7天、8天、9天、10天、11天、12天、13天或14天、約7天至約14天、約8天至約14天、約9天至約14天、約10天至約14天、約11天至約14天、約12天至約14天或約13天至約14天。在一些實施例中，第二TIL擴增可進行約14天。
在一些實施例中，可使用非特異性T細胞受體刺激在介白素-2 (IL-2)或介白素-15 (IL-15)存在下來實施擴增。非特異性T細胞受體刺激物可包含(例如)抗CD3抗體，例如約30 ng/ml OKT3、小鼠單株抗CD3抗體(可購自Ortho-McNeil, Raritan, N.J.或Miltenyi Biotech, Auburn, Calif.)或UHCT-1 (可購自BioLegend, San Diego, Calif., USA)。可藉由視情況在T細胞生長因子(例如300 IU/mL IL-2或IL-15)存在下包含一或多種癌症抗原(包含其抗原部分，例如表位)來活體外擴增CoStAR細胞，該等癌症抗原可視情況表現自載體(例如人類白血球抗原A2 (HLA-A2)結合肽，例如0.3 µM MART-1:26-35 (27L)或gp100:209-217 (210M))。其他適宜抗原可包含(例如) NY-ESO-1、TRP-1、TRP-2、酪胺酸酶癌症抗原、MAGE-A3、SSX-2及VEGFR2或其抗原部分。亦可藉由使用脈衝化於表現HLA-A2之抗原呈現細胞上之相同癌症抗原再刺激來快速擴增CoStAR細胞。或者，可使用(例如)經輻照、自體淋巴球或使用經輻照HLA-A2+同種異體淋巴球及IL-2來進一步刺激CoStAR細胞。在一些實施例中，刺激係作為擴增之一部分而發生。在一些實施例中，擴增係在經輻照、自體淋巴球或經輻照HLA-A2+同種異體淋巴球及IL-2存在下發生。
在一些實施例中，細胞培養基包括IL-2。在一些實施例中，細胞培養基包括約1000 IU/mL、約1500 IU/mL、約2000 IU/mL、約2500 IU/mL、約3000 IU/mL、約3500 IU/mL、約4000 IU/mL、約4500 IU/mL、約5000 IU/mL、約5500 IU/mL、約6000 IU/mL、約6500 IU/mL、約7000 IU/mL、約7500 IU/mL或約8000 IU/mL或介於1000 IU/mL與2000 IU/mL之間、介於2000 IU/mL與3000 IU/mL之間、介於3000 IU/mL與4000 IU/mL之間、介於4000 IU/mL與5000 IU/mL之間、介於5000 IU/mL與6000 IU/mL之間、介於6000 IU/mL與7000 IU/mL之間、介於7000 IU/mL與8000 IU/mL之間或8000 IU/mL之IL-2。
在一些實施例中，細胞培養基包括OKT3抗體。在一些實施例中，細胞培養基包括約0.1 ng/mL、約0.5 ng/mL、約1 ng/mL、約2.5 ng/mL、約5 ng/mL、約7.5 ng/mL、約10 ng/mL、約15 ng/mL、約20 ng/mL、約25 ng/mL、約30 ng/mL、約35 ng/mL、約40 ng/mL、約50 ng/mL、約60 ng/mL、約70 ng/mL、約80 ng/mL、約90 ng/mL、約100 ng/mL、約200 ng/mL、約500 ng/mL、約1 μg/mL或介於0.1 ng/mL與1 ng/mL之間、介於1 ng/mL與5 ng/mL之間、介於5 ng/mL與10 ng/mL之間、介於10 ng/mL與20 ng/mL之間、介於20 ng/mL與30 ng/mL之間、介於30 ng/mL與40 ng/mL之間、介於40 ng/mL與50 ng/mL之間或介於50 ng/mL與100 ng/mL之間之OKT3抗體。
在一些實施例中，採用IL-2、IL-7、IL-15及/或IL-21之組合作為擴增期間之組合。在一些實施例中，可在擴增期間包含IL-2、IL-7、IL-15及/或IL-21以及其任何組合。在一些實施例中，採用IL-2、IL-15及IL-21之組合作為擴增期間之組合。在一些實施例中，可包含IL-2、IL-15及IL-21以及其任何組合。
在一些實施例中，可在包括IL-2、OKT-3及抗原呈現飼養細胞之補充細胞培養基中實施擴增。
在一些實施例中，擴增培養基包括約500 IU/mL IL-15、約400 IU/mL IL-15、約300 IU/mL IL-15、約200 IU/mL IL-15、約180 IU/mL IL-15、約160 IU/mL IL-15、約140 IU/mL IL-15、約120 IU/mL IL-15或約100 IU/mL IL-15或約500 IU/mL IL-15至約100 IU/mL IL-15或約400 IU/mL IL-15至約100 IU/mL IL-15或約300 IU/mL IL-15至約100 IU/mL IL-15或約200 IU/mL IL-15或約180 IU/mL IL-15。
在一些實施例中，擴增培養基包括約20 IU/mL IL-21、約15 IU/mL IL-21、約12 IU/mL IL-21、約10 IU/mL IL-21、約5 IU/mL IL-21、約4 IU/mL IL-21、約3 IU/mL IL-21、約2 IU/mL IL-21、約1 IU/mL IL-21或約0.5 IU/mL IL-21或約20 IU/mL IL-21至約0.5 IU/mL IL-21或約15 IU/mL IL-21至約0.5 IU/mL IL-21或約12 IU/mL IL-21至約0.5 IU/mL IL-21或約10 IU/mL IL-21至約0.5 IU/mL IL-21或約5 IU/mL IL-21至約1 IU/mL IL-21或約2 IU/mL IL-21。在一些實施例中，細胞培養基包括約1 IU/mL IL-21或約0.5 IU/mL IL-21。
在一些實施例中，抗原呈現飼養細胞(APC)係PBMC。在一實施例中，擴增中之CoStAR細胞對PBMC及/或抗原呈現細胞之比率為約1:25、約1:50、約1:100、約1:125、約1:150、約1:175、約1:200、約1:225、約1:250、約1:275、約1:300、約1:325、約1:350、約1:375、約1:400或約1:500或介於1:50與1:300之間或介於1:100與1:200之間。
在某些態樣中，針對T細胞之主要刺激信號及共刺激信號可藉由不同方案來提供。舉例而言，提供每一信號之試劑可在溶液中或偶合至表面。在偶合至表面時，該等試劑可偶合至相同表面(亦即呈「順式」形式)或偶合至單獨表面(亦即呈「反式」形式)。或者，一種試劑可偶合至表面且另一試劑在溶液中。在一態樣中，提供共刺激信號之試劑與細胞表面結合，且提供初級活化信號之試劑在溶液中或偶合至表面。在某些態樣中，兩種試劑皆可在溶液中。在一態樣中，試劑可呈可溶形式，且然後與表面交聯，例如表現Fc受體之細胞或抗體或將與該等試劑結合之其他結合劑。就此而言，參見例如美國專利申請公開案第20040101519號及第20060034810號，該等公開案闡述考慮用於活化及擴增本發明T細胞之人工抗原呈現細胞(aAPC)。
在一態樣中，將兩種試劑固定在珠粒上，固定在同一珠粒上(亦即「順式」)，或固定在單獨珠粒上(亦即「反式」)。舉例而言，提供初級活化信號之試劑係抗CD3抗體或其抗原結合片段，且提供共刺激信號之試劑係抗CD28抗體或其抗原結合片段；且兩種試劑以等效分子量共固定至同一珠粒。在一態樣中，使用與用於CD4+ T細胞擴增與T細胞生長之珠粒結合之每一抗體1:1的比率。在一些實施例中，使用與珠粒結合之抗CD3:CD28抗體之比率使得與利用1:1比率觀察到之擴增相比，觀察到T細胞擴增增加。在一態樣中，與利用1:1比率觀察到之擴增相比，觀察到約1倍至約3倍的增加。在一態樣中，與珠粒結合之CD3:CD28抗體之比率介於100:1至1:100及其間之所有整數值範圍內。在一些實施例中，與粒子結合之抗CD28抗體多於抗CD3抗體，亦即，CD3:CD28之比率小於1。在一些實施例中，與珠粒結合之抗CD28抗體對抗CD3抗體之比率大於2:1。在一特定態樣中，使用與珠粒結合之抗體之1:100 CD3:CD28比率。在一態樣中，使用與珠粒結合之抗體之1:75 CD3:CD28比率。在另一態樣中，使用與珠粒結合之抗體之1:50 CD3:CD28比率。在一態樣中，使用與珠粒結合之抗體之1:30 CD3:CD28比率。在一較佳態樣中，使用與珠粒結合之抗體之1:10 CD3:CD28比率。在一態樣中，使用與珠粒結合之抗體之1:3 CD3:CD28比率。在又一態樣中，使用與珠粒結合之抗體之3:1 CD3:CD28比率。
可使用1:500至500:1及其間之任何整數值之粒子對細胞之比率來刺激T細胞或其他靶細胞。如熟習此項技術者可容易地瞭解，粒子對細胞之比率可端視粒子相對於靶細胞之大小而定。舉例而言，大小較小之珠粒僅可結合少數細胞，而較大珠粒可結合許多細胞。在某些態樣中，細胞對粒子之比率介於1:100至100:1及其間之任何整數值範圍內，且在其他態樣中，該比率包含1:9至9:1及其間之任何整數值，其亦可用於刺激T細胞。引起T細胞刺激之抗CD3及抗CD28偶合粒子對T細胞之比率可如上所述來變化，然而某些較佳值包含1:100、1:50、1:40、1:30、1:20、1:10、1:9、1:8、1:7、1:6、1:5、1:4、1:3、1:2、1:1、2:1、3:1、4:1、5:1、6:1、7:1、8:1、9:1、10:1及15:1，且一較佳比率為至少1:1粒子/T細胞。在一態樣中，使用粒子對細胞1:1或更小之比率。在一特定態樣中，較佳粒子:細胞比率為1:5。在其他態樣中，粒子對細胞比率可端視刺激時間而變化。舉例而言，在一態樣中，在第一天時粒子對細胞之比率為1:1至10:1，且每天或每隔一天此後保持10天以1:1至1:10之最終比率(基於添加時間之細胞計數)將其他粒子添加至細胞中。在一特定態樣中，在第一天刺激時粒子對細胞之比率為1:1，且在第三天及第五天刺激時調節至1:5。在一態樣中，在第一天時每天或每隔一天基於1:1之最終比率添加粒子，且在第三天及第五天刺激時基於1:5添加。在一態樣中，在第一天刺激時粒子對細胞之比率為2:1，且在第三天及第五天刺激時調節至1:10。在一態樣中，在第一天時每天或每隔一天基於1:1之最終比率添加粒子，且在第三天及第五天刺激時基於1:10添加。熟習此項技術者將瞭解，多種其他比率可適用。特定而言，比率將端視粒子大小以及細胞大小及類型而變化。在一態樣中，在第一天時所使用之最典型比率為約1:1、2:1及3:1。
在其他態樣中，組合細胞(例如T細胞)與經試劑包覆之珠粒，隨後分離珠粒與細胞，且然後培養細胞。在替代態樣中，在培養之前，不分離經試劑包覆之珠粒與細胞但一起培養。在另一態樣中，首先藉由施加力(例如磁力)對珠粒及細胞進行濃縮，從而增加細胞表面標記物之連接，由此誘導細胞刺激。 CoStAR細胞之製備
可使用基於病毒及非病毒之基因改造工具來生成CoStAR細胞(包含(但不限於) T細胞、NK細胞)，從而永久性或瞬時性表現治療基因。基於逆轉錄病毒之基因遞送係一種成熟之充分表徵之技術，其已用於將CAR永久性整合至宿主細胞基因體中(Scholler J.等人，Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci. Transl. Med. 2012;4:132ra53；Rosenberg S.A.等人，Gene transfer into humans—immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. 1990;323:570-578)。
亦可使用非病毒性DNA轉染方法。舉例而言，Singh等人闡述了研發用於改造CAR T細胞之睡美人(Sleeping Beauty, SB)轉位子系統之使用(Singh H.等人，Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res. 2008;68:2961-2971)且其正用於臨床試驗中(例如參見ClinicalTrials.gov: NCT00968760及NCT01653717)。相同技術可適用於改造CoStAR細胞。
已使用多種SB酶來遞送轉基因。Mátés闡述過度活性轉位酶(SB100X)，該過度活性轉位酶之效率與第一代轉位酶相比增強大約100倍。SB100X支持造血幹細胞或祖細胞中所富集之人類CD34(+)細胞中之35-50%之穩定基因轉移。(Mátés L.等人，Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat. Genet. 2009;41:753-761)且可自多順反子單一質體(例如Thokala R.等人，Redirecting specificity of T cells using the Sleeping Beauty system to express chimeric antigen receptors by mix-and-matching of VL and VH domains targeting CD123+ tumors. PLoS ONE. 2016;11:e0159477)或多個質體(例如Hurton L.V.等人，Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells. Proc. Natl. Acad. Sci. USA. 2016;113:E7788-E7797)遞送多種轉基因。該等系統係與CoStAR一起使用。
Morita等人闡述了用以整合較大轉基因之piggyBac轉位子系統(Morita D.等人，Enhanced expression of anti-CD19 chimeric antigen receptor in piggyBactransposon-engineered T cells. Mol. Ther. Methods Clin. Dev. 2017;8:131-140)。Nakazawa等人闡述了用以生成表現HER2特異性嵌合抗原受體之EBV特異性細胞毒性T細胞之系統之使用(Nakazawa Y等人，PiggyBac-mediated cancer immunotherapy using EBV-specific cytotoxic T-cells expressing HER2-specific chimeric antigen receptor. Mol. Ther. 2011;19:2133-2143)。Manuri等人使用用以生成CD-19特異性T細胞之系統(Manuri P.V.R.等人，piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies. Hum. Gene Ther. 2010;21:427-437)。
轉位子技術較為容易及經濟。一個潛在缺點在於，當前採用之較長擴增方案可引起T細胞分化、活性受損及較差輸注細胞持久性。Monjezi等人闡述所研發經由較高效率整合來最小化該等困難之微環載體(Monjezi R.等人，Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors. Leukemia. 2017;31:186-194)。該等轉位子技術可用於CoStAR。 醫藥組合物
本發明亦提供一種醫藥組合物，其含有載體或CoStAR表現細胞以及醫藥上可接受之載劑、稀釋劑或賦形劑及視情況一或多種其他醫藥活性多肽及/或化合物。
在一些實施例中，提供包括上述CoStAR及醫藥上可接受之載劑之醫藥組合物。在一些實施例中，提供一種醫藥組合物，其包括編碼上述任一實施例之CoStAR之核酸及醫藥上可接受之載劑。在一些實施例中，提供一種醫藥組合物，其包括表現上述CoStAR之效應細胞及醫藥上可接受之載劑。此一調配物可(例如)呈適用於靜脈內輸注之形式。
如本文中所使用，「醫藥上可接受」或「藥理學相容」意指材料並不在生物上或以其他方式不期望，舉例而言，可將材料納入投與患者之醫藥組合物中而並不引起任何顯著不期望生物效應或並不以有害方式與含有其之組合物之任一其他組份相互作用。醫藥上可接受之載劑或賦形劑較佳地符合毒物學及製造測試之所需標準及/或包含在美國食品藥物監督管理局( U.S. Food and Drug administration)編製之非活性成分指南上。
在一些實施例中，提供表現重組CoStAR之經修飾T細胞之群體。可藉由上述方法產生適宜群體。
經修飾T細胞之群體可用作藥劑。舉例而言，如本文所闡述之經修飾T細胞之群體可用於癌症免疫療法(例如過繼T細胞療法)中。
一些實施例提供如本文所闡述之經修飾T細胞之群體用以製造用於治療癌症之藥劑之用途、用於治療癌症之如本文所闡述之經修飾T細胞之群體，且癌症治療方法可包括向有需要個體投與如本文所闡述之經修飾T細胞之群體。
經修飾T細胞之群體可為自體的，亦即，經修飾T細胞最初係自其隨後投與之相同個體所獲得(亦即，捐贈個體與接受個體相同)。用於投與個體之經修飾T細胞之適宜群體可藉由包括以下步驟之方法來產生：提供自個體獲得之初始T細胞群體，修飾T細胞以表現cAMP PDE或其片段及特異性結合至個體癌細胞之抗原受體，及培養經修飾T細胞。
經修飾T細胞之群體可為同種異體的，亦即，經修飾T細胞最初係自與其隨後投與個體不同之個體所獲得(亦即，捐贈個體與接受個體不同)。捐贈個體及接受個體可HLA匹配以避免GVHD及其他不期望免疫效應。用於投與接受個體之經修飾T細胞之適宜群體可藉由包括以下步驟之方法來產生：提供自供體個體獲得之初始T細胞群體，修飾T細胞以表現特異性結合至接受個體中之癌細胞之CoStAR，及培養經修飾T細胞。
在投與經修飾T細胞後，接受個體可展現針對接受個體中之癌細胞之T細胞介導之免疫反應。此可對個體之癌症病狀具有有益效應。
癌症病狀之特徵可在於惡性癌細胞之異常增殖，且可包含白血病(例如AML、CML、ALL及CLL)、淋巴瘤(例如何傑金氏淋巴瘤(Hodgkin lymphoma)、非何傑金氏淋巴瘤及多發性骨髓瘤)及實體癌(例如肉瘤、皮膚癌、黑色素瘤、膀胱癌、腦癌、乳癌、子宮癌、卵巢癌、前列腺癌、肺癌、結腸直腸癌、子宮頸癌、肝癌、頭頸癌、食道癌、胰臟癌、腎癌、腎上腺癌、胃癌、睪丸癌、膽囊及膽管癌、甲狀腺癌、胸腺癌、骨癌及大腦癌)以及未明原發癌(CUP)。
個體內之癌細胞可在免疫學上不同於個體中之正常體細胞(亦即，癌性腫瘤可為免疫原性)。舉例而言，癌細胞可能能夠在個體中誘發針對一或多種由癌細胞表現之抗原之全身性免疫反應。誘發免疫反應之腫瘤抗原可對癌細胞具有特異性或可由個體中之一或多種正常細胞所共有。
適用於如上文所闡述之治療之個體可為哺乳動物，例如齧齒類動物(例如天竺鼠、倉鼠、大鼠、小鼠)、鼠類(例如小鼠)、犬類(例如狗)、貓類(例如貓)、馬類(例如馬)、靈長類動物、猿類(例如猴或猿)、猴(例如絨猴、狒狒)、猿(例如大猩猩、黑猩猩、紅毛猩猩、長臂猿)或人類。
在較佳實施例中，個體係人類。在其他較佳實施例中，可採用非人類哺乳動物，尤其係通常用作用於證實人類中之治療效能之哺乳動物之模型(例如鼠類、靈長類、豬類、犬類或兔類動物)。 治療方法
表現CoStAR之細胞(包含T及NK細胞)可自患者之自有周邊血(自體)或在造血幹細胞移植之情況下自供體周邊血(同種異體)或自無關供體之周邊血(同種異體)離體產生。在一些實施例中，T細胞或NK細胞可源自可誘導祖細胞或胚胎祖細胞向T細胞或NK細胞之離體分化。在該等情況下，藉由經由許多方式之一(包含使用病毒載體轉導、使用DNA或RNA轉染)引入編碼CoStAR及視情況CAR及/或TCR之DNA或RNA來生成表現CoStAR及視情況CAR及/或TCR之T細胞。
表現CoStAR且視情況表現TCR及/或CAR之T或NK細胞可用於治療血液系統癌症或實體腫瘤。
在一些實施例中，提供一種細胞治療方法，其包括鑑別需要腫瘤浸潤淋巴球(「TIL」)細胞療法之個體及向個體投與TIL細胞療法。TIL細胞療法包括如本文所提供之融合蛋白(例如CEA CoStAR及/或融合蛋白或MSLN CoStAR及/或融合蛋白)，該融合蛋白可包括特異性(例如對CEA CoStAR及/或融合蛋白或MSLN CoStAR及/或融合蛋白具有特異性)連接至跨膜結構域之結合結構域，該跨膜結構域連接至CD28信號傳導結構域(針對MSLN，或針對CEA之ICOS結構域)，該信號傳導結構域連接至CD40信號傳導結構域。
術語「治療有效量」係指如本文所揭示之CoStAR或包括CoStAR之組合物有效「治療」個體之疾病或病症之量。在癌症情形下，治療有效量之如本文所揭示之CoStAR或包括CoStAR之組合物可減少癌細胞數；減小腫瘤大小或重量；抑制(亦即在一定程度上減慢且較佳終止)癌細胞浸潤至周圍器官中；抑制(亦即在一定程度上減慢且較佳終止)腫瘤轉移；在一定程度上抑制腫瘤生長；及/或在一定程度上減輕與癌症相關之一或多種症狀。就如本文所揭示之CoStAR或包括CoStAR之組合物可預防現有癌細胞之生長及/或殺死該等細胞而言，其可為細胞生長抑制及/或細胞毒性的。在一些實施例中，治療有效量係生長抑制量。在一些實施例中，治療有效量係改良患者之無進展存活之量。在感染性疾病(例如病毒感染)之情形下，治療有效量之如本文所揭示之CoStAR或包括CoStAR之組合物可減小由病原體感染之細胞數；降低病原體源抗原之產生或釋放；抑制(亦即在一定程度上減緩及較佳地停止)病原體向未感染細胞之擴散；及/或在一定程度上減輕一或多種與感染有關之症狀。在一些實施例中，治療有效量係延長患者存活期之量。
用於本發明方法中之表現CoStAR之細胞(包含T及NK細胞)可自患者之自有周邊血(自體)或在造血幹細胞移植之情況下自供體周邊血(同種異體)或自無關供體之周邊血(同種異體)離體產生。或者，T細胞或NK細胞可源自可誘導祖細胞或胚胎祖細胞向T細胞或NK細胞之離體分化。在該等情況下，藉由經由許多方式之一(包含使用病毒載體轉導、使用DNA或RNA轉染)引入編碼CoStAR及視情況CAR及/或TCR之DNA或RNA來生成表現CoStAR及視情況CAR及/或TCR之T細胞。
表現如本文所揭示之CoStAR且視情況表現TCR及/或CAR之T或NK細胞可用於治療血液系統癌症或實體腫瘤。
一種治療疾病之方法涉及如本文所揭示之載體或細胞(包含T或NK細胞)之治療應用。就此而言，可將載體或T或NK細胞投與患有現有疾病或病狀之個體以減弱、減少或改良至少一種與該疾病有關之症狀及/或減緩、減小或阻止該疾病之進展。在一些實施例中，該方法可引起或促進T細胞介導之癌細胞殺死。在一些實施例中，載體或T或NK細胞可與一或多種其他治療劑一起投與患者。可將一或多種其他治療劑共投與患者。「共投與」意指在時間上足夠接近地投與一或多種其他治療劑及如本文所提供之載體或T或NK細胞，從而載體或T或NK細胞可增強一或多種其他治療劑之效應，或反之亦然。就此而言，可首先投與載體或細胞，且可隨後投與一或多種其他治療劑，或反之亦然。或者，可同時投與載體或細胞及一或多種其他治療劑。可有用之一種共投與治療劑係IL-2，此乃因此物質當前用於現有細胞療法中以加強所投與細胞之活性。然而，IL-2治療涉及毒性及耐受性問題。
如所提及，對於患者投與而言，CoStAR效應細胞可對於患者為同種異體或自體的。在一些實施例中，藉由(例如)基因編輯來進一步基因修飾同種異體細胞以最小化或預防GVHD及/或患者針對CoStAR細胞之免疫反應。
使用CoStAR效應細胞來治療與靶抗原有關之癌症及贅瘤性疾病。可使用本文所闡述之任一方法治療之癌症及贅瘤性疾病包含未血管化或尚未實質上血管化之腫瘤以及血管化腫瘤。癌症可包括非實體腫瘤(例如血液系統腫瘤，例如白血病及淋巴瘤)或可包括實體腫瘤。擬使用CoStAR效應細胞治療之癌症類型包含(但不限於)癌瘤、母細胞瘤及肉瘤、及某些白血病或淋巴樣惡性腫瘤、良性及惡性腫瘤以及惡性腫瘤(例如肉瘤、癌瘤及黑色素瘤)。亦包含成人腫瘤/癌症及兒科腫瘤/癌症。
血液系統癌症係血液或骨髓之癌症。血液系統(或血源性)癌症之實例包含白血病(包含急性白血病(例如急性淋巴球性白血病、急性骨髓細胞性白血病、急性骨髓性白血病以及骨髓母細胞性白血病、前髓細胞性白血病、骨髓單核球性白血病、單核球性白血病及紅白血病)、慢性白血病(例如慢性骨髓細胞性(顆粒球性)白血病、慢性骨髓性白血病及慢性淋巴球性白血病))、真性多血症、淋巴瘤、何傑金氏病、非何傑金氏淋巴瘤(無痛及高級形式)、多發性骨髓瘤、漿細胞瘤、沃爾登斯特倫氏巨球蛋白血症(Waldenstrom's macroglobulinemia)、重鏈病、骨髓發育不良症候群、毛細胞白血病及骨髓發育不良。
實體腫瘤係通常不含有囊腫或液體區域之異常組織塊。實體腫瘤可為良性或惡性。不同類型之實體腫瘤係根據形成其之細胞類型來命名(例如肉瘤、癌瘤及淋巴瘤)。實體腫瘤(例如肉瘤及癌瘤)之實例包含腎上腺皮質癌、膽管癌、纖維肉瘤、黏液肉瘤、脂肪肉瘤、軟骨肉瘤、骨肉瘤及其他肉瘤、滑膜瘤、間皮瘤、尤恩氏腫瘤(Ewing's tumor)、平滑肌肉瘤、橫紋肌肉瘤、結腸癌、胃癌、淋巴樣惡性腫瘤、胰臟癌、乳癌、肺癌、卵巢癌、前列腺癌、肝細胞癌、鱗狀細胞癌、基底細胞癌、腺癌、汗腺癌、甲狀腺癌(例如髓質甲狀腺癌及乳頭狀甲狀腺癌)、嗜鉻細胞瘤、皮脂腺癌、乳頭狀癌、乳頭狀腺癌、髓質癌、支氣管原癌、腎細胞癌、肝細胞瘤、膽管癌、絨毛膜癌、維爾姆斯氏腫瘤(Wilms' tumor)、子宮頸癌(例如子宮頸癌瘤及侵襲前子宮頸發育不良)、結腸直腸癌、肛門、肛管或肛腸癌、陰道癌、外陰癌(例如鱗狀細胞癌、上皮內癌、腺癌及纖維肉瘤)、陰莖癌、口咽癌、食道癌、頭癌(例如鱗狀細胞癌)、頸癌(例如鱗狀細胞癌)、睪丸癌(例如精原細胞瘤、畸胎瘤、胚胎癌、畸形癌、絨毛膜癌、肉瘤、雷丁氏細胞腫瘤(Leydig cell tumor)、纖維瘤、纖維腺瘤、類腺瘤腫瘤及脂肪瘤)、膀胱癌、腎癌、黑色素瘤、子宮癌(例如子宮內膜癌)、泌尿道上皮癌(例如鱗狀細胞癌、移行細胞癌、腺癌、輸尿管癌及膀胱癌)及CNS腫瘤(例如神經膠質瘤(例如腦幹神經膠質瘤及混合型神經膠質瘤)、神經膠母細胞瘤(亦稱為多形性神經膠母細胞瘤)、星形細胞瘤、CNS淋巴瘤、生殖細胞瘤、髓母細胞瘤、神經鞘瘤、顱咽管瘤、室管膜瘤、松果體瘤、血管母細胞瘤、聽神經瘤、寡樹突神經膠質瘤、腦膜瘤、神經母細胞瘤、視網膜母細胞瘤及腦轉移)。
在指示「免疫有效量」、「抗腫瘤有效量」、「腫瘤抑制有效量」或「治療量」時，擬投與組合物之精確量可由醫師根據患者(個體)之年齡、體重、腫瘤大小、感染或轉移程度及病狀之個體差異來確定。通常可陳述，包括本文所闡述T細胞之醫藥組合物可以10 4至10 9個細胞/kg體重、在一些情況下10 5至10 6個細胞/kg體重(包含該等範圍內之所有整數值)之劑量來投與。T細胞組合物亦可以該等劑量投與多次。該等細胞可藉由利用免疫療法中通常已知之輸注技術來投與(例如參見Rosenberg等人，New Eng. J. of Med. 319:1676, 198)。
在一些實施例中，其他方法態樣部分地或完整地展示於圖83及83中。
在一些實施例中，劑量可為1×10^9個CoStAR陽性(CoStAR+)活T細胞(± 20%靶劑量)。在一些實施例中，劑量可為或增至5×10^8個CoStAR+活T細胞(±20%靶劑量)。在一些實施例中，劑量可為或增至3×10^9個CoStAR+活T細胞(±20%靶劑量)。在一些實施例中，劑量可為或增至6×10^9個CoStAR+活T細胞(±20%靶劑量)。在一些實施例中，劑量為前述值中之至少任一者。在一些實施例中，劑量介於任兩個前述值之間。 組合療法
本文所闡述之CoStAR表現細胞可與其他已知藥劑及療法組合使用。本文所用之「組合」投與意指，在個體患病期間將兩種(或更多種)不同治療遞送至個體，例如在個體已經診斷患有病症之後且在病症治癒或消除之前或治療已出於其他原因停止之前遞送兩種或更多種治療。在一些實施例中，一種治療之遞送仍在第二種治療開始遞送時進行，從而存在投與重疊。此在本文中有時稱為「同時」或「並行」遞送。在其他實施例中，一種治療在開始遞送另一種治療之前結束遞送。在任一情形的一些實施例中，治療因組合投與而更為有效。舉例而言，與不存在第一治療時投與第二治療所觀察者相比，第二治療更有效，例如利用更少第二治療觀察到等效效應，或第二治療更大程度地減少症狀，或利用第一治療觀察到類似情況。在一些實施例中，遞送使得症狀或與病症相關之其他參數之減輕程度比利用在不存在另一種治療之情況下遞送一種治療所觀察到的減輕程度更高。兩次治療之效應可為部分加和、完全加和或大於加和。遞送可使得在遞送第二治療時仍可檢測所遞送之第一治療的作用。
本文所闡述之CoStAR表現細胞與至少一種其他治療劑可以同一或單獨組合物同步或依序投與。對於依序投與，可首先投與本文所闡述之CAR表現細胞，且可其次投與另一藥劑，或可顛倒投與順序。
CoStAR療法及/或其他治療劑、程序或模式可在活性病症時段期間或在緩解或活性較低之疾病時段期間投與。CoStAR療法可在另一治療之前、與該治療同時、在治療後或在病症緩解期間投與。
在組合投與時，該療法及另一藥劑(例如第二或第三藥劑)或所有藥劑皆可以高於、低於或等於每一藥劑個別使用(例如作為單一療法)之量或劑量的量或劑量來投與。在一些實施例中，CoStAR療法、另一藥劑(例如第二或第三藥劑)或所有藥劑之投與量或劑量低於每一藥劑個別使用(例如作為單一療法)之量或劑量(例如低至少20%、至少30%、至少40%或至少50%)。在其他實施例中，CoStAR療法、另一藥劑(例如第二或第三藥劑)或所有藥劑之產生期望效應(例如治療癌症)之量或劑量低於(例如低至少20%、至少30%、至少40%或至少50%)個別使用之每一藥劑(例如作為單一療法)達成相同治療效應所需的量或劑量。
在其他態樣中，本文所闡述之CoStAR表現細胞可與以下各項組合用於治療方案中：手術、化學療法、放射、免疫抑制劑(例如環孢素、硫唑嘌呤(azathioprine)、胺甲蝶呤(methotrexate)、黴酚酸酯(mycophenolate)及FK506)、抗體或其他免疫燒蝕劑(例如CAMPATH、抗CD3抗體或其他抗體療法)、細胞毒素、氟達拉濱(fludarabine)、環孢素、FK506、雷帕黴素(rapamycin)、黴酚酸(mycophenolic acid)、類固醇、FR901228、細胞介素及輻照、肽疫苗(例如Izumoto等人，2008 J Neurosurg 108:963-971中所闡述者)。
在一些實施例中，如本文所揭示之化合物與其他治療劑進行組合，該等治療劑係(例如)其他抗癌劑、抗過敏劑、抗噁心劑(或抗嘔吐劑)、疼痛緩解劑、細胞保護劑及其組合。
在一實施例中，本文所闡述之CoStAR表現細胞可與化學治療劑組合使用。實例性化學治療劑包含蒽環(例如多柔比星(doxorubicin) (例如脂質體多柔比星))、長春花生物鹼(例如長春鹼(vinblastine)、長春新鹼(vincristine)、長春地辛(vindesine)、長春瑞濱(vinorelbine))、烷基化劑(例如環磷醯胺(cyclophosphamide)、達卡巴嗪(decarbazine)、美法侖(melphalan)、異環磷醯胺(ifosfamide)、替莫唑胺(temozolomide))、免疫細胞抗體(例如阿倫單抗(alemtuzamab)、吉妥單抗(gemtuzumab)、利妥昔單抗(rituximab)、歐法單抗(ofatumumab)、托西莫單抗(tositumomab)、布妥昔單抗(brentuximab))、抗代謝物(包含(例如)葉酸拮抗劑、嘧啶類似物、嘌呤類似物及腺苷去胺酶抑制劑(例如氟達拉濱))、mTOR抑制劑、TNFR糖皮質激素誘導之TNFR相關蛋白(GITR)激動劑、蛋白酶體抑制劑(例如阿克拉黴素(aclacinomycin) A、黴膠毒素或硼替佐米(bortezomib))、免疫調節劑(例如沙利竇邁(thalidomide)或沙利竇邁衍生物(例如雷利竇邁(lenalidomide)))。
考慮用於組合療法中之一般化學治療劑包含白消安(busulfan) (Myleran®)、白消安注射劑(Busulfex®)、克拉屈濱(cladribine) (Leustatin®)、環磷醯胺(Cytoxan®或Neosar®)、阿糖胞苷(cytarabine)、胞嘧啶阿糖核苷(cytosine arabinoside) (Cytosar-U®)、阿糖胞苷脂質體注射劑(DepoCyt®)、柔紅黴素鹽酸鹽(daunorubicin hydrochloride) (Cerubidine®)、檸檬酸柔紅黴素(daunorubicin citrate)脂質體注射劑(DaunoXome®)、地塞米松(dexamethasone)、多柔比星鹽酸鹽(Adriamycin®、Rubex®)、依託泊苷(etoposide) (Vepesid®)、磷酸氟達拉濱(Fludara®)、羥基脲(hydroxyurea) (Hydrea®)、伊達比星(Idarubicin) (Idamycin®)、米托蒽醌(mitoxantrone) (Novantrone®)、吉妥珠單抗-奧佐米星(Gemtuzumab Ozogamicin)(mylotarg®)。
在實施例中，考慮用於組合療法中之一般化學治療劑包含阿那曲唑(anastrozole) (Arimidex®)、比卡魯胺(bicalutamide) (Casodex®)、硫酸博來黴素(bleomycin sulfate) (Blenoxane®)、白消安(Myleran®)、白消安注射劑(Busulfex®)、卡培他濱(capecitabine) (Xeloda®)、N4-戊氧基羰基-5-去氧-5-氟胞苷、卡鉑(carboplatin) (Paraplatin®)、卡莫司汀(carmustine) (BiCNU®)、氯芥苯丁酸(Leukeran®)、順鉑(cisplatin) (Platinol®)、克拉屈濱(Leustatin®)、環磷醯胺(Cytoxan®或Neosar®)、阿糖胞苷、胞嘧啶阿糖核苷(Cytosar-U®)、阿糖胞苷脂質體注射劑(DepoCyt®)、達卡巴嗪(dacarbazine) (DTIC-Dome®)、更生黴素(dactinomycin) (放線菌素D (Actinomycin D)，Cosmegan)、柔紅黴素鹽酸鹽(Cerubidine®)、檸檬酸柔紅黴素脂質體注射劑(DaunoXome®)、地塞米松、多西紫杉醇(docetaxel) (Taxotere®)、多柔比星鹽酸鹽(Adriamycin®、Rubex®)、依託泊苷(Vepesid®)、磷酸氟達拉濱(Fludara®)、5-氟尿嘧啶(5-fluorouracil) (Adrucil®、Efudex®)、氟利坦(flutamide) (Eulexin®)、替紮他濱(tezacitibine)、吉西他濱(Gemcitabine) (雙氟去氧胞苷)、羥基脲(Hydrea®)、伊達比星(Idamycin®)、異環磷醯胺(IFEX®)、伊立替康(irinotecan) (Camptosar®)、L-天門冬醯胺酶(ELSPAR®)、甲硫四氫葉酸鈣、美法侖(Alkeran®)、6-巰基嘌呤(Purinethol®)、胺甲蝶呤(Folex®)、米托蒽醌(Novantrone®)、滅髓瘤(mylotarg)、太平洋紫杉醇(paclitaxel) (Taxol®)、菲尼克斯(phoenix) (釔90/MX-DTPA)、噴司他丁(pentostatin)、聚苯丙生20 (polifeprosan 20)與卡莫司汀植入物(Gliadel®)、檸檬酸他莫昔芬(tamoxifen citrate) (Nolvadex®)、替尼泊苷(teniposide) (Vumon®)、6-硫鳥嘌呤、塞替派(thiotepa)、替拉紮明(tirapazamine)(Tirazone®)、注射用鹽酸拓樸替康(Hycamptin®)、長春花鹼(Velban®)、長春新鹼(Oncovin®)及長春瑞濱(Navelbine®)。
可(例如)藉由以下各項來評估治療：腫瘤消退、腫瘤重量或大小收縮、進展時間、存活持續時間、無進展存活、整體反應率、反應持續時間、生活品質、蛋白質表現及/或活性。可採用測定療法效能之方式，包含(例如)經由放射性成像來量測反應。
在一些實施例中，表7及/或 圖 83及 84中所使用或提供之任一序列可採用於本文所提供之方法中。在 圖 83及 84中，加下劃線加粗體區包括CDR。在一些實施例中，融合蛋白之抗原結合結構域可靶向CEA。在一些實施例中，融合蛋白之抗原結合結構域可靶向CEA。在一些實施例中，融合蛋白之抗原結合結構域可靶向MSLN。在一些實施例中，此結構域包含SEQ ID NO: 12之某一部分及/或SEQ ID NO: 186-191之一些部分及/或其變體。在一些實施例中，融合蛋白或CoSTaR包括提供於 圖 84中之MSLN構築體組分(全部或一部分或其變體)。在一些實施例中，此結構包含SEQ ID NO: 192、218、228、246、264或282 (全部或一部分或其變體)。 序列
下列序列包含完整CoStAR及CoStAR組分且係非限制性的。組分包含信號肽(SP)、結合結構域(BD)、連接體、間隔體及跨膜結構域(STM)、不含細胞外或細胞內序列之CD28跨膜片段(STM-CD28TM)、細胞內信號結構域(SD)以及CD40結構域及模體。儘管SEQ ID NO:42-247或196-335、362-363、369-420及514包括具有N末端信號肽之CoStAR，但應理解，N末端信號肽已自成熟CoStAR去除。另外，應理解，成熟CoStAR可在N末端處缺乏1、2、3、4、5、6、7、8、9或10個或更多個胺基酸(亦即自信號肽之C末端計數)。全蛋白內之組分位置可自本文所呈現之實例性序列以及自基因庫及其他來源予以證實。構築體及組分在精確大小及程度方面係闡釋性的且組分可來自一種以上來源。在存在一個以上細胞內信號傳導結構域或信號傳導片段之情形下，多個結構域可呈任何順序。應理解，儘管某些蛋白質在表現時可包括N末端信號肽，但該等信號肽發生裂解且在表現蛋白質時可不精確地裂解，且自其去除信號肽之所得蛋白質包括在N末端胺基酸之位置中具有最多約5個胺基酸之變化的結合結構域。
表7 -胺基酸序列
ID No 組分 序列
1 SP-OSM MGVLLTQRTL LSLVLALLFP SMASM
2 SP-CD8α MALPVTALLL PLALLLHAAR P
3 SP-CD2 MSFPCKFVAS FLLIFNVSSK GAVS
4 SP-IL2 MYRMQLLSCI ALSLALVTNS
5 SP-GM-CSF MWLQSLLLLG TVACSIS
6 SP-hIgGk-VIII MEAPAQLLFL LLLWLPDTTR
7 SP-PD1 MGVLLTQRTL LSLVLALLFP SMASM
8 SP-TIGIT MQIPQAPWPV VWAVLQLGWR PGW
9 BD1-MOV QVQLQQSGAE LVKPGASVKI SCKASGYSFT GYFMNWVKQS HGKSLEWIGR IHPYDGDTFY NQNFKDKATL TVDKSSNTAH MELLSLTSED FAVYYCTRYD GSRAMDYWGQ GTTVTVSSGG GGSGGGGSGG GGSDIELTQS PASLAVSLGQ RAIISCKASQ SVSFAGTSLM HWYHQKPGQQ PKLLIYRASN LEAGVPTRFS GSGSKTDFTL NIHPVEEEDA ATYYCQQSRE YPYTFGGGTK LEIK
10 MFE23 QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KR
11 MFE23(K＞Q) QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KR
12 hMFE23 QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI K
13 CEA6 QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKR
14 BW431/26 QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKR
15 HuT84.66(M5A) EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIK
16 BD1-PD1 RPGWFLDSPD RPWNPPTFSP ALLVVTEGDN ATFTCSFSNT SESFVLNWYR MSPSNQTDKL AAFPEDRSQP GQDCRFRVTQ LPNGRDFHMS VVRARRNDSG TYLCGAISLA PKAQIKESLR AELRVTERRA EVPTAH
17 BD1-TIGIT MMTGTIETTG NISAEKGGSI ILQCHLSSTT AQVTQVNWEQ QDQLLAICNA DLGWHISPSF KDRVAPGPGL GLTLQSLTVN DTGEYFCIYH TYPDGTYTGR IFLEVLESSV AEHGARFQIP
18 3XA2Xgsg AAAGSGGSG
19 STM-spCD28 ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWV
20 STM-spCD8 FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRN
21 STM-CD28TM FWVLVVVGGV LACYSLLVTV AFIIFWV
22 STM-spCD28TM CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWV
23 STM-CD28IIH(trun) IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWV
24 STM-spIG4 ESKYGPPCPS CPAPEFLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY VDGVEVHNAK TKPREEQFNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK AKGQPREPQV YTLPPSQEEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM HEALHNHYTQ KSLSLSLGKM FWVLVVVGGV LACYSLLVTV AFIIFWV
25 Sig-CD28 RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR S
26 Sig-CD137 RFSVVKRGRK KLLYIFKQPF MRPVQTTQEE DGCSCRFPEE EEGGCE
27 Sig-CD134 RRDQRLPPDA HKPPGGGSFR TPIQEEQADA HSTLAKI
28 Sig-CD2 KRKKQRSRRN DEELETRAHR VATEERGRKP HQIPASTPQN PATSQHPPPP PGHRSQAPSH RPPPPGHRVQ HQPQKRPPAP SGTQVHQQKG PPLPRPRVQP KPPHGAAENS LSPSSN
29 Sig GITR QLGLHIWQLR SQCMWPRETQ LLLEVPPSTE DARSCQFPEE ERGERSAEEK GRLGDLWV
30 Sig-CD29 KLLMIIHDRR EFAKFEKEKM NAKWDTGENP IYKSAVTTVV NPKYEGK
31 Sig-CD150 RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES
32 CD40 KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
33 CD40_串聯 AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER QKKVA
34 CD40_ P227A KKVAKKPTNK AAHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
35 SH3_模體 KPTNKAPH
36 TRAF2_模體1 PKQE
37 TRAF2_模體2 PVQE
38 TRAF2_模體3 SVQE
39 TRAF6_模體 QEPQEINFP
40 PKA_模體1 KKPTNKA
41 PKA_模體2 SRISVQE
42 OSM_ MFE23 _spCD28 _CD28_ CD40 CTP194 MGVLLTQRTL LSLVLALLFP SMASMQVKLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
43 CD8α_MFE23 _spCD28 _CD28_CD40 CTP255 MALPVTALLL PLALLLHAAR PQVKLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
44 CD2_MFE23 _spCD28 _CD28_CD40 CTP256 MSFPCKFVAS FLLIFNVSSK GAVSQVKLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
45 IL2_MFE23 _spCD28 _CD28_CD40 CTP257 MYRMQLLSCI ALSLALVTNS QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
46 GM-CSF_MFE23 _spCD28 _CD28_CD40 CTP258 MWLQSLLLLG TVACSISQVK LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
47 hIgGk-VIII_MFE23 _spCD28 _CD28_CD40 CTP259 MEAPAQLLFL LLLWLPDTTR QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
48 OSM_MFE23 _spCD8 _CD28_CD40 CTP190 MGVLLTQRTL LSLVLALLFP SMASMQVKLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
49 CD8a_MFE23 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
50 CD2_MFE23 _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
51 IL2_MFE23 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
52 GM-CSF_MFE23 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVK LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
53 hIgGk-VIII_MFE23 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
54 OSM_MFE23 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVKLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
55 CD8a_MFE23 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
56 CD2_MFE23 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
57 IL2_MFE23 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
58 GM-CSF_MFE23 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVK LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
59 hIgGk-VIII_MFE23 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
60 OSM_MFE23 (K＞Q)_spCD28 _CD28_CD40 CTP219 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
61 CD8a_MFE23 (K＞Q)_spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
62 CD2_MFE23(K＞Q) _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
63 IL2_MFE23(K＞Q) _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
64 GM-CSF _MFE23 (K＞Q) _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
65 hIgGk-VIII _MFE23(K＞Q) _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
66 OSM_MFE23(K＞Q) _spCD8 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
67 CD8a _MFE23(K＞Q) _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
68 CD2_MFE23(K＞Q) _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
69 IL2_MFE23(K＞Q) _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
70 GM-CSF _MFE23(K＞Q) _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
71 hIgGk-VIII _MFE23(K＞Q) _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
72 OSM_MFE23(K＞Q) _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
73 CD8a _MFE23(K＞Q) _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
74 CD2_MFE23(K＞Q) _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
75 IL2_MFE23(K＞Q) _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
76 GM-CSF _MFE23(K＞Q) _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
77 hIgGk-VIII _MFE23(K＞Q) _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
78 OSM_HuMFE23 _spCD28 _CD28_CD40 CTP220 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
79 CD8a_HuMFE23 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLEQSGA EVVKPGASVK LSCKASGFNI KDSYMHWLRQ GPGQRLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSANTA YLGLSSLRPE DTAVYYCNEG TPTGPYYFDY WGQGTLVTVS SGGGGSGGGG SGGGGSENVL TQSPSSMSAS VGDRVNIACS ASSSVSYMHW FQQKPGKSPK LWIYSTSNLA SGVPSRFSGS GSGTDYSLTI SSMQPEDAAT YYCQQRSSYP LTFGGGTKLE IKAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
80 CD2_HuMFE23 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLEQ SGAEVVKPGA SVKLSCKASG FNIKDSYMHW LRQGPGQRLE WIGWIDPENG DTEYAPKFQG KATFTTDTSA NTAYLGLSSL RPEDTAVYYC NEGTPTGPYY FDYWGQGTLV TVSSGGGGSG GGGSGGGGSE NVLTQSPSSM SASVGDRVNI ACSASSSVSY MHWFQQKPGK SPKLWIYSTS NLASGVPSRF SGSGSGTDYS LTISSMQPED AATYYCQQRS SYPLTFGGGT KLEIKAAAGS GGSGILVKQS PMLVAYDNAV NLSCKYSYNL FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
81 IL2_HuMFE23 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
82 GM-CSF_HuMFE23 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVK LEQSGAEVVK PGASVKLSCK ASGFNIKDSY MHWLRQGPGQ RLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSANTAYLGL SSLRPEDTAV YYCNEGTPTG PYYFDYWGQG TLVTVSSGGG GSGGGGSGGG GSENVLTQSP SSMSASVGDR VNIACSASSS VSYMHWFQQK PGKSPKLWIY STSNLASGVP SRFSGSGSGT DYSLTISSMQ PEDAATYYCQ QRSSYPLTFG GGTKLEIKAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
83 hIgGk-VIII _HuMFE23 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
84 OSM_HuMFE23 _spCD8 _CD28_CD40 CTP232 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
85 CD8a_HuMFE23 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLEQSGA EVVKPGASVK LSCKASGFNI KDSYMHWLRQ GPGQRLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSANTA YLGLSSLRPE DTAVYYCNEG TPTGPYYFDY WGQGTLVTVS SGGGGSGGGG SGGGGSENVL TQSPSSMSAS VGDRVNIACS ASSSVSYMHW FQQKPGKSPK LWIYSTSNLA SGVPSRFSGS GSGTDYSLTI SSMQPEDAAT YYCQQRSSYP LTFGGGTKLE IKAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
86 CD2_HuMFE23 _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLEQ SGAEVVKPGA SVKLSCKASG FNIKDSYMHW LRQGPGQRLE WIGWIDPENG DTEYAPKFQG KATFTTDTSA NTAYLGLSSL RPEDTAVYYC NEGTPTGPYY FDYWGQGTLV TVSSGGGGSG GGGSGGGGSE NVLTQSPSSM SASVGDRVNI ACSASSSVSY MHWFQQKPGK SPKLWIYSTS NLASGVPSRF SGSGSGTDYS LTISSMQPED AATYYCQQRS SYPLTFGGGT KLEIKAAAGS GGSGFVPVFL PAKPTTTPAP RPPTPAPTIA SQPLSLRPEA CRPAAGGAVH TRGLDFACDI YIWAPLAGTC GVLLLSLVIT LYCNHRNRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
87 IL2_HuMFE23 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
88 GM-CSF_HuMFE23 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVK LEQSGAEVVK PGASVKLSCK ASGFNIKDSY MHWLRQGPGQ RLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSANTAYLGL SSLRPEDTAV YYCNEGTPTG PYYFDYWGQG TLVTVSSGGG GSGGGGSGGG GSENVLTQSP SSMSASVGDR VNIACSASSS VSYMHWFQQK PGKSPKLWIY STSNLASGVP SRFSGSGSGT DYSLTISSMQ PEDAATYYCQ QRSSYPLTFG GGTKLEIKAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
89 hIgGk-VIII _HuMFE23 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
90 OSM_HuMFE23 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
91 CD8a_HuMFE23 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLEQSGA EVVKPGASVK LSCKASGFNI KDSYMHWLRQ GPGQRLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSANTA YLGLSSLRPE DTAVYYCNEG TPTGPYYFDY WGQGTLVTVS SGGGGSGGGG SGGGGSENVL TQSPSSMSAS VGDRVNIACS ASSSVSYMHW FQQKPGKSPK LWIYSTSNLA SGVPSRFSGS GSGTDYSLTI SSMQPEDAAT YYCQQRSSYP LTFGGGTKLE IKAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
92 CD2_HuMFE23 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLEQ SGAEVVKPGA SVKLSCKASG FNIKDSYMHW LRQGPGQRLE WIGWIDPENG DTEYAPKFQG KATFTTDTSA NTAYLGLSSL RPEDTAVYYC NEGTPTGPYY FDYWGQGTLV TVSSGGGGSG GGGSGGGGSE NVLTQSPSSM SASVGDRVNI ACSASSSVSY MHWFQQKPGK SPKLWIYSTS NLASGVPSRF SGSGSGTDYS LTISSMQPED AATYYCQQRS SYPLTFGGGT KLEIKAAAGS GGSGFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
93 IL2_HuMFE23 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
94 GM-CSF_HuMFE23 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVK LEQSGAEVVK PGASVKLSCK ASGFNIKDSY MHWLRQGPGQ RLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSANTAYLGL SSLRPEDTAV YYCNEGTPTG PYYFDYWGQG TLVTVSSGGG GSGGGGSGGG GSENVLTQSP SSMSASVGDR VNIACSASSS VSYMHWFQQK PGKSPKLWIY STSNLASGVP SRFSGSGSGT DYSLTISSMQ PEDAATYYCQ QRSSYPLTFG GGTKLEIKAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
95 hIgGk-VIII _HuMFE23 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
96 OSM_CEA6 _spCD28 _CD28_CD40 CTP221 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKKPG SSVKVSCKAS GGTFSNSPIN WLRQAPGQGL EWMGSIIPSF GTANYAQKFQ GRLTITADES TSTAYMELSS LRSEDTAVYY CAGRSHNYEL YYYYMDVWGQ GTMVTVSSGG GGSGGGGSGG GGSDIQMTQS PSTLSASIGD RVTITCRASE GIYHWLAWYQ QKPGKAPKLL IYKASSLASG APSRFSGSGS GTDFTLTISS LQPDDFATYY CQQYSNYPLT FGGGTKLEIK RAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
97 CD8a_CEA6 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKKPGSSVK VSCKASGGTF SNSPINWLRQ APGQGLEWMG SIIPSFGTAN YAQKFQGRLT ITADESTSTA YMELSSLRSE DTAVYYCAGR SHNYELYYYY MDVWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
98 CD2_CEA6 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKKPGS SVKVSCKASG GTFSNSPINW LRQAPGQGLE WMGSIIPSFG TANYAQKFQG RLTITADEST STAYMELSSL RSEDTAVYYC AGRSHNYELY YYYMDVWGQG TMVTVSSGGG GSGGGGSGGG GSDIQMTQSP STLSASIGDR VTITCRASEG IYHWLAWYQQ KPGKAPKLLI YKASSLASGA PSRFSGSGSG TDFTLTISSL QPDDFATYYC QQYSNYPLTF GGGTKLEIKR AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
99 IL2_CEA6 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
100 GM-CSF_CEA6 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKK PGSSVKVSCK ASGGTFSNSP INWLRQAPGQ GLEWMGSIIP SFGTANYAQK FQGRLTITAD ESTSTAYMEL SSLRSEDTAV YYCAGRSHNY ELYYYYMDVW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKRAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
101 hIgGk-VIII_CEA6 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
102 OSM_CEA6 _spCD8 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKKPG SSVKVSCKAS GGTFSNSPIN WLRQAPGQGL EWMGSIIPSF GTANYAQKFQ GRLTITADES TSTAYMELSS LRSEDTAVYY CAGRSHNYEL YYYYMDVWGQ GTMVTVSSGG GGSGGGGSGG GGSDIQMTQS PSTLSASIGD RVTITCRASE GIYHWLAWYQ QKPGKAPKLL IYKASSLASG APSRFSGSGS GTDFTLTISS LQPDDFATYY CQQYSNYPLT FGGGTKLEIK RAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
103 CD8a_CEA6 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKKPGSSVK VSCKASGGTF SNSPINWLRQ APGQGLEWMG SIIPSFGTAN YAQKFQGRLT ITADESTSTA YMELSSLRSE DTAVYYCAGR SHNYELYYYY MDVWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
104 CD2_CEA6 _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKKPGS SVKVSCKASG GTFSNSPINW LRQAPGQGLE WMGSIIPSFG TANYAQKFQG RLTITADEST STAYMELSSL RSEDTAVYYC AGRSHNYELY YYYMDVWGQG TMVTVSSGGG GSGGGGSGGG GSDIQMTQSP STLSASIGDR VTITCRASEG IYHWLAWYQQ KPGKAPKLLI YKASSLASGA PSRFSGSGSG TDFTLTISSL QPDDFATYYC QQYSNYPLTF GGGTKLEIKR AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
105 IL2_CEA6 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
106 GM-CSF_CEA6 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKK PGSSVKVSCK ASGGTFSNSP INWLRQAPGQ GLEWMGSIIP SFGTANYAQK FQGRLTITAD ESTSTAYMEL SSLRSEDTAV YYCAGRSHNY ELYYYYMDVW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKRAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
107 hIgGk-VIII _CEA6 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
108 OSM_CEA6 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKKPG SSVKVSCKAS GGTFSNSPIN WLRQAPGQGL EWMGSIIPSF GTANYAQKFQ GRLTITADES TSTAYMELSS LRSEDTAVYY CAGRSHNYEL YYYYMDVWGQ GTMVTVSSGG GGSGGGGSGG GGSDIQMTQS PSTLSASIGD RVTITCRASE GIYHWLAWYQ QKPGKAPKLL IYKASSLASG APSRFSGSGS GTDFTLTISS LQPDDFATYY CQQYSNYPLT FGGGTKLEIK RAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
109 CD8a_CEA6 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKKPGSSVK VSCKASGGTF SNSPINWLRQ APGQGLEWMG SIIPSFGTAN YAQKFQGRLT ITADESTSTA YMELSSLRSE DTAVYYCAGR SHNYELYYYY MDVWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKRAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
110 CD2_CEA6 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKKPGS SVKVSCKASG GTFSNSPINW LRQAPGQGLE WMGSIIPSFG TANYAQKFQG RLTITADEST STAYMELSSL RSEDTAVYYC AGRSHNYELY YYYMDVWGQG TMVTVSSGGG GSGGGGSGGG GSDIQMTQSP STLSASIGDR VTITCRASEG IYHWLAWYQQ KPGKAPKLLI YKASSLASGA PSRFSGSGSG TDFTLTISSL QPDDFATYYC QQYSNYPLTF GGGTKLEIKR AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
111 IL2_CEA6 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
112 GM-CSF_CEA6 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKK PGSSVKVSCK ASGGTFSNSP INWLRQAPGQ GLEWMGSIIP SFGTANYAQK FQGRLTITAD ESTSTAYMEL SSLRSEDTAV YYCAGRSHNY ELYYYYMDVW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKRAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
113 hIgGk-VIII _CEA6 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
114 OSM_BW431/26 _spCD28 _CD28_CD40 CTP222 MGVLLTQRTL LSLVLALLFP SMASMQLQES GPGLVRPSQT LSLTCTVSGF TISSGYSWHW VRQPPGRGLE WIGYIQYSGI TNYNPSLKSR VTMLVDTSKN QFSLRLSSVT AADTAVYYCA REDYDYHWYF DVWGQGSLVT VSSGGGGSGG GGSGGGGSGV HSDIQMTQSP SSLSASVGDR VTITCSTSSS VSYMHWYQQK PGKAPKLLIY STSNLASGVP SRFSGSGSGT DFTFTISSLQ PEDIATYYCH QWSSYPTFGQ GTKVEIKRAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
115 CD8a_BW431/26 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQLQESGPGL VRPSQTLSLT CTVSGFTISS GYSWHWVRQP PGRGLEWIGY IQYSGITNYN PSLKSRVTML VDTSKNQFSL RLSSVTAADT AVYYCAREDY DYHWYFDVWG QGSLVTVSSG GGGSGGGGSG GGGSGVHSDI QMTQSPSSLS ASVGDRVTIT CSTSSSVSYM HWYQQKPGKA PKLLIYSTSN LASGVPSRFS GSGSGTDFTF TISSLQPEDI ATYYCHQWSS YPTFGQGTKV EIKRAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
116 CD2_BW431/26 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQLQESG PGLVRPSQTL SLTCTVSGFT ISSGYSWHWV RQPPGRGLEW IGYIQYSGIT NYNPSLKSRV TMLVDTSKNQ FSLRLSSVTA ADTAVYYCAR EDYDYHWYFD VWGQGSLVTV SSGGGGSGGG GSGGGGSGVH SDIQMTQSPS SLSASVGDRV TITCSTSSSV SYMHWYQQKP GKAPKLLIYS TSNLASGVPS RFSGSGSGTD FTFTISSLQP EDIATYYCHQ WSSYPTFGQG TKVEIKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
117 IL2_BW431/26 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
118 GM-CSF _BW431/26 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQLQ ESGPGLVRPS QTLSLTCTVS GFTISSGYSW HWVRQPPGRG LEWIGYIQYS GITNYNPSLK SRVTMLVDTS KNQFSLRLSS VTAADTAVYY CAREDYDYHW YFDVWGQGSL VTVSSGGGGS GGGGSGGGGS GVHSDIQMTQ SPSSLSASVG DRVTITCSTS SSVSYMHWYQ QKPGKAPKLL IYSTSNLASG VPSRFSGSGS GTDFTFTISS LQPEDIATYY CHQWSSYPTF GQGTKVEIKR AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
119 hIgGk-VIII _BW431/26 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
120 OSM_BW431/26 _spCD8 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQLQES GPGLVRPSQT LSLTCTVSGF TISSGYSWHW VRQPPGRGLE WIGYIQYSGI TNYNPSLKSR VTMLVDTSKN QFSLRLSSVT AADTAVYYCA REDYDYHWYF DVWGQGSLVT VSSGGGGSGG GGSGGGGSGV HSDIQMTQSP SSLSASVGDR VTITCSTSSS VSYMHWYQQK PGKAPKLLIY STSNLASGVP SRFSGSGSGT DFTFTISSLQ PEDIATYYCH QWSSYPTFGQ GTKVEIKRAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
121 CD8a_BW431/26 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQLQESGPGL VRPSQTLSLT CTVSGFTISS GYSWHWVRQP PGRGLEWIGY IQYSGITNYN PSLKSRVTML VDTSKNQFSL RLSSVTAADT AVYYCAREDY DYHWYFDVWG QGSLVTVSSG GGGSGGGGSG GGGSGVHSDI QMTQSPSSLS ASVGDRVTIT CSTSSSVSYM HWYQQKPGKA PKLLIYSTSN LASGVPSRFS GSGSGTDFTF TISSLQPEDI ATYYCHQWSS YPTFGQGTKV EIKRAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
122 CD2_BW431/26 _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQLQESG PGLVRPSQTL SLTCTVSGFT ISSGYSWHWV RQPPGRGLEW IGYIQYSGIT NYNPSLKSRV TMLVDTSKNQ FSLRLSSVTA ADTAVYYCAR EDYDYHWYFD VWGQGSLVTV SSGGGGSGGG GSGGGGSGVH SDIQMTQSPS SLSASVGDRV TITCSTSSSV SYMHWYQQKP GKAPKLLIYS TSNLASGVPS RFSGSGSGTD FTFTISSLQP EDIATYYCHQ WSSYPTFGQG TKVEIKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
123 IL2_BW431/26 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
124 GM-CSF_BW431/26 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQLQ ESGPGLVRPS QTLSLTCTVS GFTISSGYSW HWVRQPPGRG LEWIGYIQYS GITNYNPSLK SRVTMLVDTS KNQFSLRLSS VTAADTAVYY CAREDYDYHW YFDVWGQGSL VTVSSGGGGS GGGGSGGGGS GVHSDIQMTQ SPSSLSASVG DRVTITCSTS SSVSYMHWYQ QKPGKAPKLL IYSTSNLASG VPSRFSGSGS GTDFTFTISS LQPEDIATYY CHQWSSYPTF GQGTKVEIKR AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
125 hIgGk-VIII_BW431/26 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
126 OSM_BW431/26 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQLQES GPGLVRPSQT LSLTCTVSGF TISSGYSWHW VRQPPGRGLE WIGYIQYSGI TNYNPSLKSR VTMLVDTSKN QFSLRLSSVT AADTAVYYCA REDYDYHWYF DVWGQGSLVT VSSGGGGSGG GGSGGGGSGV HSDIQMTQSP SSLSASVGDR VTITCSTSSS VSYMHWYQQK PGKAPKLLIY STSNLASGVP SRFSGSGSGT DFTFTISSLQ PEDIATYYCH QWSSYPTFGQ GTKVEIKRAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
127 CD8a_BW431/26 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQLQESGPGL VRPSQTLSLT CTVSGFTISS GYSWHWVRQP PGRGLEWIGY IQYSGITNYN PSLKSRVTML VDTSKNQFSL RLSSVTAADT AVYYCAREDY DYHWYFDVWG QGSLVTVSSG GGGSGGGGSG GGGSGVHSDI QMTQSPSSLS ASVGDRVTIT CSTSSSVSYM HWYQQKPGKA PKLLIYSTSN LASGVPSRFS GSGSGTDFTF TISSLQPEDI ATYYCHQWSS YPTFGQGTKV EIKRAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
128 CD2_BW431/26 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQLQESG PGLVRPSQTL SLTCTVSGFT ISSGYSWHWV RQPPGRGLEW IGYIQYSGIT NYNPSLKSRV TMLVDTSKNQ FSLRLSSVTA ADTAVYYCAR EDYDYHWYFD VWGQGSLVTV SSGGGGSGGG GSGGGGSGVH SDIQMTQSPS SLSASVGDRV TITCSTSSSV SYMHWYQQKP GKAPKLLIYS TSNLASGVPS RFSGSGSGTD FTFTISSLQP EDIATYYCHQ WSSYPTFGQG TKVEIKRAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
129 IL2_BW431/26 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
130 GM-CSF _BW431/26 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQLQ ESGPGLVRPS QTLSLTCTVS GFTISSGYSW HWVRQPPGRG LEWIGYIQYS GITNYNPSLK SRVTMLVDTS KNQFSLRLSS VTAADTAVYY CAREDYDYHW YFDVWGQGSL VTVSSGGGGS GGGGSGGGGS GVHSDIQMTQ SPSSLSASVG DRVTITCSTS SSVSYMHWYQ QKPGKAPKLL IYSTSNLASG VPSRFSGSGS GTDFTFTISS LQPEDIATYY CHQWSSYPTF GQGTKVEIKR AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
131 hIgGk-VIII _BW431/26 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
132 OSM_HuT84.66 _spCD28 _CD28_CD40 CTP223 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFNIKDTYMH WVRQAPGKGL EWVARIDPAN GNSKYADSVK GRFTISADTS KNTAYLQMNS LRAEDTAVYY CAPFGYYVSD YAMAYWGQGT LVTVSSGGGG SGGGGSGGGG SDIQLTQSPS SLSASVGDRV TITCRAGESV DIFGVGFLHW YQQKPGKAPK LLIYRASNLE SGVPSRFSGS GSRTDFTLTI SSLQPEDFAT YYCQQTNEDP YTFGQGTKVE IKAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
133 CD8a_HuT84.66 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFNI KDTYMHWVRQ APGKGLEWVA RIDPANGNSK YADSVKGRFT ISADTSKNTA YLQMNSLRAE DTAVYYCAPF GYYVSDYAMA YWGQGTLVTV SSGGGGSGGG GSGGGGSDIQ LTQSPSSLSA SVGDRVTITC RAGESVDIFG VGFLHWYQQK PGKAPKLLIY RASNLESGVP SRFSGSGSRT DFTLTISSLQ PEDFATYYCQ QTNEDPYTFG QGTKVEIKAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
134 CD2_HuT84.66 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FNIKDTYMHW VRQAPGKGLE WVARIDPANG NSKYADSVKG RFTISADTSK NTAYLQMNSL RAEDTAVYYC APFGYYVSDY AMAYWGQGTL VTVSSGGGGS GGGGSGGGGS DIQLTQSPSS LSASVGDRVT ITCRAGESVD IFGVGFLHWY QQKPGKAPKL LIYRASNLES GVPSRFSGSG SRTDFTLTIS SLQPEDFATY YCQQTNEDPY TFGQGTKVEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
135 IL2_HuT84.66 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
136 GM-CSF_HuT84.66 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFNIKDTY MHWVRQAPGK GLEWVARIDP ANGNSKYADS VKGRFTISAD TSKNTAYLQM NSLRAEDTAV YYCAPFGYYV SDYAMAYWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQLTQS PSSLSASVGD RVTITCRAGE SVDIFGVGFL HWYQQKPGKA PKLLIYRASN LESGVPSRFS GSGSRTDFTL TISSLQPEDF ATYYCQQTNE DPYTFGQGTK VEIKAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
137 hIgGk-VIII_HuT84.66 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
138 OSM_HuT84.66_spCD8 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFNIKDTYMH WVRQAPGKGL EWVARIDPAN GNSKYADSVK GRFTISADTS KNTAYLQMNS LRAEDTAVYY CAPFGYYVSD YAMAYWGQGT LVTVSSGGGG SGGGGSGGGG SDIQLTQSPS SLSASVGDRV TITCRAGESV DIFGVGFLHW YQQKPGKAPK LLIYRASNLE SGVPSRFSGS GSRTDFTLTI SSLQPEDFAT YYCQQTNEDP YTFGQGTKVE IKAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
139 CD8a_HuT84.66 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFNI KDTYMHWVRQ APGKGLEWVA RIDPANGNSK YADSVKGRFT ISADTSKNTA YLQMNSLRAE DTAVYYCAPF GYYVSDYAMA YWGQGTLVTV SSGGGGSGGG GSGGGGSDIQ LTQSPSSLSA SVGDRVTITC RAGESVDIFG VGFLHWYQQK PGKAPKLLIY RASNLESGVP SRFSGSGSRT DFTLTISSLQ PEDFATYYCQ QTNEDPYTFG QGTKVEIKAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
140 CD2_HuT84.66_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FNIKDTYMHW VRQAPGKGLE WVARIDPANG NSKYADSVKG RFTISADTSK NTAYLQMNSL RAEDTAVYYC APFGYYVSDY AMAYWGQGTL VTVSSGGGGS GGGGSGGGGS DIQLTQSPSS LSASVGDRVT ITCRAGESVD IFGVGFLHWY QQKPGKAPKL LIYRASNLES GVPSRFSGSG SRTDFTLTIS SLQPEDFATY YCQQTNEDPY TFGQGTKVEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
141 IL2_HuT84.66 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
142 GM-CSF_HuT84.66 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFNIKDTY MHWVRQAPGK GLEWVARIDP ANGNSKYADS VKGRFTISAD TSKNTAYLQM NSLRAEDTAV YYCAPFGYYV SDYAMAYWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQLTQS PSSLSASVGD RVTITCRAGE SVDIFGVGFL HWYQQKPGKA PKLLIYRASN LESGVPSRFS GSGSRTDFTL TISSLQPEDF ATYYCQQTNE DPYTFGQGTK VEIKAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
143 hIgGk-VIII_HuT84.66 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
144 OSM_HuT84.66 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFNIKDTYMH WVRQAPGKGL EWVARIDPAN GNSKYADSVK GRFTISADTS KNTAYLQMNS LRAEDTAVYY CAPFGYYVSD YAMAYWGQGT LVTVSSGGGG SGGGGSGGGG SDIQLTQSPS SLSASVGDRV TITCRAGESV DIFGVGFLHW YQQKPGKAPK LLIYRASNLE SGVPSRFSGS GSRTDFTLTI SSLQPEDFAT YYCQQTNEDP YTFGQGTKVE IKAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
145 CD8a_HuT84.66 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFNI KDTYMHWVRQ APGKGLEWVA RIDPANGNSK YADSVKGRFT ISADTSKNTA YLQMNSLRAE DTAVYYCAPF GYYVSDYAMA YWGQGTLVTV SSGGGGSGGG GSGGGGSDIQ LTQSPSSLSA SVGDRVTITC RAGESVDIFG VGFLHWYQQK PGKAPKLLIY RASNLESGVP SRFSGSGSRT DFTLTISSLQ PEDFATYYCQ QTNEDPYTFG QGTKVEIKAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
146 CD2_HuT84.66 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FNIKDTYMHW VRQAPGKGLE WVARIDPANG NSKYADSVKG RFTISADTSK NTAYLQMNSL RAEDTAVYYC APFGYYVSDY AMAYWGQGTL VTVSSGGGGS GGGGSGGGGS DIQLTQSPSS LSASVGDRVT ITCRAGESVD IFGVGFLHWY QQKPGKAPKL LIYRASNLES GVPSRFSGSG SRTDFTLTIS SLQPEDFATY YCQQTNEDPY TFGQGTKVEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
147 IL2_HuT84.66 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
148 GM-CSF_HuT84.66 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFNIKDTY MHWVRQAPGK GLEWVARIDP ANGNSKYADS VKGRFTISAD TSKNTAYLQM NSLRAEDTAV YYCAPFGYYV SDYAMAYWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQLTQS PSSLSASVGD RVTITCRAGE SVDIFGVGFL HWYQQKPGKA PKLLIYRASN LESGVPSRFS GSGSRTDFTL TISSLQPEDF ATYYCQQTNE DPYTFGQGTK VEIKAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
149 hIgGk-VIII_HuT84.66 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
150 OSM_MFE23 _spCD28(trun) _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVKLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
151 CD8a_MFE23 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
152 CD2_MFE23 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
153 IL2_MFE23 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
154 GM-CSF_MFE23 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVK LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
155 hIgGk-VIII_MFE23 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
156 OSM_MFE23(K＞Q) _spCD28(trun) _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
157 CD8a _MFE23(K＞Q) _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGA ELVRSGTSVK LSCTASGFNI KDSYMHWLRQ GPEQGLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSSNTA YLQLSSLTSE DTAVYYCNEG TPTGPYYFDY WGQGTTVTVS SGGGGSGGGG SGGGGSENVL TQSPAIMSAS PGEKVTITCS ASSSVSYMHW FQQKPGTSPK LWIYSTSNLA SGVPARFSGS GSGTSYSLTI SRMEAEDAAT YYCQQRSSYP LTFGAGTKLE LKRAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
158 CD2_MFE23(K＞Q) _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGAELVRSGT SVKLSCTASG FNIKDSYMHW LRQGPEQGLE WIGWIDPENG DTEYAPKFQG KATFTTDTSS NTAYLQLSSL TSEDTAVYYC NEGTPTGPYY FDYWGQGTTV TVSSGGGGSG GGGSGGGGSE NVLTQSPAIM SASPGEKVTI TCSASSSVSY MHWFQQKPGT SPKLWIYSTS NLASGVPARF SGSGSGTSYS LTISRMEAED AATYYCQQRS SYPLTFGAGT KLELKRAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
159 IL2_MFE23(K＞Q)_spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
160 GM-CSF _MFE23(K＞Q) _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGAELVR SGTSVKLSCT ASGFNIKDSY MHWLRQGPEQ GLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSSNTAYLQL SSLTSEDTAV YYCNEGTPTG PYYFDYWGQG TTVTVSSGGG GSGGGGSGGG GSENVLTQSP AIMSASPGEK VTITCSASSS VSYMHWFQQK PGTSPKLWIY STSNLASGVP ARFSGSGSGT SYSLTISRME AEDAATYYCQ QRSSYPLTFG AGTKLELKRA AAGSGGSGII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
161 hIgGk-VIII _MFE23(K＞Q) _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGAE LVRSGTSVKL SCTASGFNIK DSYMHWLRQG PEQGLEWIGW IDPENGDTEY APKFQGKATF TTDTSSNTAY LQLSSLTSED TAVYYCNEGT PTGPYYFDYW GQGTTVTVSS GGGGSGGGGS GGGGSENVLT QSPAIMSASP GEKVTITCSA SSSVSYMHWF QQKPGTSPKL WIYSTSNLAS GVPARFSGSG SGTSYSLTIS RMEAEDAATY YCQQRSSYPL TFGAGTKLEL KRAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
162 OSM_HuMFE23 _spCD28(trun) _CD28_CD40 CTP244 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
163 CD8a_HuMFE23 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVKLEQSGA EVVKPGASVK LSCKASGFNI KDSYMHWLRQ GPGQRLEWIG WIDPENGDTE YAPKFQGKAT FTTDTSANTA YLGLSSLRPE DTAVYYCNEG TPTGPYYFDY WGQGTLVTVS SGGGGSGGGG SGGGGSENVL TQSPSSMSAS VGDRVNIACS ASSSVSYMHW FQQKPGKSPK LWIYSTSNLA SGVPSRFSGS GSGTDYSLTI SSMQPEDAAT YYCQQRSSYP LTFGGGTKLE IKAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
164 CD2_HuMFE23 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVKLEQ SGAEVVKPGA SVKLSCKASG FNIKDSYMHW LRQGPGQRLE WIGWIDPENG DTEYAPKFQG KATFTTDTSA NTAYLGLSSL RPEDTAVYYC NEGTPTGPYY FDYWGQGTLV TVSSGGGGSG GGGSGGGGSE NVLTQSPSSM SASVGDRVNI ACSASSSVSY MHWFQQKPGK SPKLWIYSTS NLASGVPSRF SGSGSGTDYS LTISSMQPED AATYYCQQRS SYPLTFGGGT KLEIKAAAGS GGSGIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
165 IL2_HuMFE23 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
166 GM-CSF_HuMFE23 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVK LEQSGAEVVK PGASVKLSCK ASGFNIKDSY MHWLRQGPGQ RLEWIGWIDP ENGDTEYAPK FQGKATFTTD TSANTAYLGL SSLRPEDTAV YYCNEGTPTG PYYFDYWGQG TLVTVSSGGG GSGGGGSGGG GSENVLTQSP SSMSASVGDR VNIACSASSS VSYMHWFQQK PGKSPKLWIY STSNLASGVP SRFSGSGSGT DYSLTISSMQ PEDAATYYCQ QRSSYPLTFG GGTKLEIKAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
167 hIgGk-VIII _HuMFE23 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVKLEQSGAE VVKPGASVKL SCKASGFNIK DSYMHWLRQG PGQRLEWIGW IDPENGDTEY APKFQGKATF TTDTSANTAY LGLSSLRPED TAVYYCNEGT PTGPYYFDYW GQGTLVTVSS GGGGSGGGGS GGGGSENVLT QSPSSMSASV GDRVNIACSA SSSVSYMHWF QQKPGKSPKL WIYSTSNLAS GVPSRFSGSG SGTDYSLTIS SMQPEDAATY YCQQRSSYPL TFGGGTKLEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
168 OSM_CEA6 _spCD28(trun) _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKKPG SSVKVSCKAS GGTFSNSPIN WLRQAPGQGL EWMGSIIPSF GTANYAQKFQ GRLTITADES TSTAYMELSS LRSEDTAVYY CAGRSHNYEL YYYYMDVWGQ GTMVTVSSGG GGSGGGGSGG GGSDIQMTQS PSTLSASIGD RVTITCRASE GIYHWLAWYQ QKPGKAPKLL IYKASSLASG APSRFSGSGS GTDFTLTISS LQPDDFATYY CQQYSNYPLT FGGGTKLEIK RAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
169 CD8a_CEA6 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKKPGSSVK VSCKASGGTF SNSPINWLRQ APGQGLEWMG SIIPSFGTAN YAQKFQGRLT ITADESTSTA YMELSSLRSE DTAVYYCAGR SHNYELYYYY MDVWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKRAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
170 CD2_CEA6 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKKPGS SVKVSCKASG GTFSNSPINW LRQAPGQGLE WMGSIIPSFG TANYAQKFQG RLTITADEST STAYMELSSL RSEDTAVYYC AGRSHNYELY YYYMDVWGQG TMVTVSSGGG GSGGGGSGGG GSDIQMTQSP STLSASIGDR VTITCRASEG IYHWLAWYQQ KPGKAPKLLI YKASSLASGA PSRFSGSGSG TDFTLTISSL QPDDFATYYC QQYSNYPLTF GGGTKLEIKR AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
171 IL2_CEA6 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
172 GM-CSF_CEA6 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKK PGSSVKVSCK ASGGTFSNSP INWLRQAPGQ GLEWMGSIIP SFGTANYAQK FQGRLTITAD ESTSTAYMEL SSLRSEDTAV YYCAGRSHNY ELYYYYMDVW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKRAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
173 hIgGk-VIII _CEA6 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKKPGSSVKV SCKASGGTFS NSPINWLRQA PGQGLEWMGS IIPSFGTANY AQKFQGRLTI TADESTSTAY MELSSLRSED TAVYYCAGRS HNYELYYYYM DVWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKRAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
174 OSM_BW431/26 _spCD28(trun) _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQLQES GPGLVRPSQT LSLTCTVSGF TISSGYSWHW VRQPPGRGLE WIGYIQYSGI TNYNPSLKSR VTMLVDTSKN QFSLRLSSVT AADTAVYYCA REDYDYHWYF DVWGQGSLVT VSSGGGGSGG GGSGGGGSGV HSDIQMTQSP SSLSASVGDR VTITCSTSSS VSYMHWYQQK PGKAPKLLIY STSNLASGVP SRFSGSGSGT DFTFTISSLQ PEDIATYYCH QWSSYPTFGQ GTKVEIKRAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
175 CD8a_BW431/26_spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQLQESGPGL VRPSQTLSLT CTVSGFTISS GYSWHWVRQP PGRGLEWIGY IQYSGITNYN PSLKSRVTML VDTSKNQFSL RLSSVTAADT AVYYCAREDY DYHWYFDVWG QGSLVTVSSG GGGSGGGGSG GGGSGVHSDI QMTQSPSSLS ASVGDRVTIT CSTSSSVSYM HWYQQKPGKA PKLLIYSTSN LASGVPSRFS GSGSGTDFTF TISSLQPEDI ATYYCHQWSS YPTFGQGTKV EIKRAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
176 CD2_BW431/26 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQLQESG PGLVRPSQTL SLTCTVSGFT ISSGYSWHWV RQPPGRGLEW IGYIQYSGIT NYNPSLKSRV TMLVDTSKNQ FSLRLSSVTA ADTAVYYCAR EDYDYHWYFD VWGQGSLVTV SSGGGGSGGG GSGGGGSGVH SDIQMTQSPS SLSASVGDRV TITCSTSSSV SYMHWYQQKP GKAPKLLIYS TSNLASGVPS RFSGSGSGTD FTFTISSLQP EDIATYYCHQ WSSYPTFGQG TKVEIKRAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
177 IL2_BW431/26 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
178 GM-CSF _BW431/26 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQLQ ESGPGLVRPS QTLSLTCTVS GFTISSGYSW HWVRQPPGRG LEWIGYIQYS GITNYNPSLK SRVTMLVDTS KNQFSLRLSS VTAADTAVYY CAREDYDYHW YFDVWGQGSL VTVSSGGGGS GGGGSGGGGS GVHSDIQMTQ SPSSLSASVG DRVTITCSTS SSVSYMHWYQ QKPGKAPKLL IYSTSNLASG VPSRFSGSGS GTDFTFTISS LQPEDIATYY CHQWSSYPTF GQGTKVEIKR AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
179 hIgGk-VIII _BW431/26 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QLQESGPGLV RPSQTLSLTC TVSGFTISSG YSWHWVRQPP GRGLEWIGYI QYSGITNYNP SLKSRVTMLV DTSKNQFSLR LSSVTAADTA VYYCAREDYD YHWYFDVWGQ GSLVTVSSGG GGSGGGGSGG GGSGVHSDIQ MTQSPSSLSA SVGDRVTITC STSSSVSYMH WYQQKPGKAP KLLIYSTSNL ASGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCHQWSSY PTFGQGTKVE IKRAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
180 OSM_HuT84.66 _spCD28(trun) _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFNIKDTYMH WVRQAPGKGL EWVARIDPAN GNSKYADSVK GRFTISADTS KNTAYLQMNS LRAEDTAVYY CAPFGYYVSD YAMAYWGQGT LVTVSSGGGG SGGGGSGGGG SDIQLTQSPS SLSASVGDRV TITCRAGESV DIFGVGFLHW YQQKPGKAPK LLIYRASNLE SGVPSRFSGS GSRTDFTLTI SSLQPEDFAT YYCQQTNEDP YTFGQGTKVE IKAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
181 CD8a_HuT84.66 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFNI KDTYMHWVRQ APGKGLEWVA RIDPANGNSK YADSVKGRFT ISADTSKNTA YLQMNSLRAE DTAVYYCAPF GYYVSDYAMA YWGQGTLVTV SSGGGGSGGG GSGGGGSDIQ LTQSPSSLSA SVGDRVTITC RAGESVDIFG VGFLHWYQQK PGKAPKLLIY RASNLESGVP SRFSGSGSRT DFTLTISSLQ PEDFATYYCQ QTNEDPYTFG QGTKVEIKAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
182 CD2_HuT84.66 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FNIKDTYMHW VRQAPGKGLE WVARIDPANG NSKYADSVKG RFTISADTSK NTAYLQMNSL RAEDTAVYYC APFGYYVSDY AMAYWGQGTL VTVSSGGGGS GGGGSGGGGS DIQLTQSPSS LSASVGDRVT ITCRAGESVD IFGVGFLHWY QQKPGKAPKL LIYRASNLES GVPSRFSGSG SRTDFTLTIS SLQPEDFATY YCQQTNEDPY TFGQGTKVEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
183 IL2_HuT84.66 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
184 GM-CSF_HuT84.66 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFNIKDTY MHWVRQAPGK GLEWVARIDP ANGNSKYADS VKGRFTISAD TSKNTAYLQM NSLRAEDTAV YYCAPFGYYV SDYAMAYWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQLTQS PSSLSASVGD RVTITCRAGE SVDIFGVGFL HWYQQKPGKA PKLLIYRASN LESGVPSRFS GSGSRTDFTL TISSLQPEDF ATYYCQQTNE DPYTFGQGTK VEIKAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
185 hIgGk-VIII_HuT84.66 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYMHWVRQA PGKGLEWVAR IDPANGNSKY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCAPFG YYVSDYAMAY WGQGTLVTVS SGGGGSGGGG SGGGGSDIQL TQSPSSLSAS VGDRVTITCR AGESVDIFGV GFLHWYQQKP GKAPKLLIYR ASNLESGVPS RFSGSGSRTD FTLTISSLQP EDFATYYCQQ TNEDPYTFGQ GTKVEIKAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
186 SS1 QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK
187 M5 (人類化SS1) QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIK
188 HN1 QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI K
189 M912 QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI K
190 HuYP218 EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEI
191 P4 QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLS
192 OSM_SS1 _spCD28 _CD28_CD40 CTP224 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPELEKPG ASVKLSCKAS GYSFTGYTMN WVKQSHGKSL EWIGLITPYN GASSYNQKFR GKATLTVDKS SSTAYMDLLS LTSEDSAVYF CARGGYDGRG FDYWGQGTTV TVSSGGGGSG GGGSGGGGSD IELTQSPAIM SASPGEKVTM TCSASSSVSY MHWYQQKSGT SPKRWIYDTS KLASGVPGRF SGSGSGNSYS LTISSVEAED DATYYCQQWS KHPLTFGAGT KLEIKAAAGS GGSGILVKQS PMLVAYDNAV NLSCKYSYNL FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
193 CD8a_SS1 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP ELEKPGASVK LSCKASGYSF TGYTMNWVKQ SHGKSLEWIG LITPYNGASS YNQKFRGKAT LTVDKSSSTA YMDLLSLTSE DSAVYFCARG GYDGRGFDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIELT QSPAIMSASP GEKVTMTCSA SSSVSYMHWY QQKSGTSPKR WIYDTSKLAS GVPGRFSGSG SGNSYSLTIS SVEAEDDATY YCQQWSKHPL TFGAGTKLEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
194 CD2_SS1 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPELEKPGA SVKLSCKASG YSFTGYTMNW VKQSHGKSLE WIGLITPYNG ASSYNQKFRG KATLTVDKSS STAYMDLLSL TSEDSAVYFC ARGGYDGRGF DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPAIMS ASPGEKVTMT CSASSSVSYM HWYQQKSGTS PKRWIYDTSK LASGVPGRFS GSGSGNSYSL TISSVEAEDD ATYYCQQWSK HPLTFGAGTK LEIKAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
195 IL2_SS1 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
196 GM-CSF_SS1 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPELEK PGASVKLSCK ASGYSFTGYT MNWVKQSHGK SLEWIGLITP YNGASSYNQK FRGKATLTVD KSSSTAYMDL LSLTSEDSAV YFCARGGYDG RGFDYWGQGT TVTVSSGGGG SGGGGSGGGG SDIELTQSPA IMSASPGEKV TMTCSASSSV SYMHWYQQKS GTSPKRWIYD TSKLASGVPG RFSGSGSGNS YSLTISSVEA EDDATYYCQQ WSKHPLTFGA GTKLEIKAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
197 hIgGk-VIII_SS1 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
198 OSM_SS1_spCD8 _CD28_CD40 CTP236 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPELEKPG ASVKLSCKAS GYSFTGYTMN WVKQSHGKSL EWIGLITPYN GASSYNQKFR GKATLTVDKS SSTAYMDLLS LTSEDSAVYF CARGGYDGRG FDYWGQGTTV TVSSGGGGSG GGGSGGGGSD IELTQSPAIM SASPGEKVTM TCSASSSVSY MHWYQQKSGT SPKRWIYDTS KLASGVPGRF SGSGSGNSYS LTISSVEAED DATYYCQQWS KHPLTFGAGT KLEIKAAAGS GGSGFVPVFL PAKPTTTPAP RPPTPAPTIA SQPLSLRPEA CRPAAGGAVH TRGLDFACDI YIWAPLAGTC GVLLLSLVIT LYCNHRNRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
199 CD8a_SS1 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP ELEKPGASVK LSCKASGYSF TGYTMNWVKQ SHGKSLEWIG LITPYNGASS YNQKFRGKAT LTVDKSSSTA YMDLLSLTSE DSAVYFCARG GYDGRGFDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIELT QSPAIMSASP GEKVTMTCSA SSSVSYMHWY QQKSGTSPKR WIYDTSKLAS GVPGRFSGSG SGNSYSLTIS SVEAEDDATY YCQQWSKHPL TFGAGTKLEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
200 CD2_SS1_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPELEKPGA SVKLSCKASG YSFTGYTMNW VKQSHGKSLE WIGLITPYNG ASSYNQKFRG KATLTVDKSS STAYMDLLSL TSEDSAVYFC ARGGYDGRGF DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPAIMS ASPGEKVTMT CSASSSVSYM HWYQQKSGTS PKRWIYDTSK LASGVPGRFS GSGSGNSYSL TISSVEAEDD ATYYCQQWSK HPLTFGAGTK LEIKAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
201 IL2_SS1_spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
202 GM-CSF_SS1 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPELEK PGASVKLSCK ASGYSFTGYT MNWVKQSHGK SLEWIGLITP YNGASSYNQK FRGKATLTVD KSSSTAYMDL LSLTSEDSAV YFCARGGYDG RGFDYWGQGT TVTVSSGGGG SGGGGSGGGG SDIELTQSPA IMSASPGEKV TMTCSASSSV SYMHWYQQKS GTSPKRWIYD TSKLASGVPG RFSGSGSGNS YSLTISSVEA EDDATYYCQQ WSKHPLTFGA GTKLEIKAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
203 hIgGk-VIII _SS1_spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
204 OSM_SS1 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPELEKPG ASVKLSCKAS GYSFTGYTMN WVKQSHGKSL EWIGLITPYN GASSYNQKFR GKATLTVDKS SSTAYMDLLS LTSEDSAVYF CARGGYDGRG FDYWGQGTTV TVSSGGGGSG GGGSGGGGSD IELTQSPAIM SASPGEKVTM TCSASSSVSY MHWYQQKSGT SPKRWIYDTS KLASGVPGRF SGSGSGNSYS LTISSVEAED DATYYCQQWS KHPLTFGAGT KLEIKAAAGS GGSGFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
205 CD8a_SS1 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP ELEKPGASVK LSCKASGYSF TGYTMNWVKQ SHGKSLEWIG LITPYNGASS YNQKFRGKAT LTVDKSSSTA YMDLLSLTSE DSAVYFCARG GYDGRGFDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIELT QSPAIMSASP GEKVTMTCSA SSSVSYMHWY QQKSGTSPKR WIYDTSKLAS GVPGRFSGSG SGNSYSLTIS SVEAEDDATY YCQQWSKHPL TFGAGTKLEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
206 CD2_SS1 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPELEKPGA SVKLSCKASG YSFTGYTMNW VKQSHGKSLE WIGLITPYNG ASSYNQKFRG KATLTVDKSS STAYMDLLSL TSEDSAVYFC ARGGYDGRGF DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPAIMS ASPGEKVTMT CSASSSVSYM HWYQQKSGTS PKRWIYDTSK LASGVPGRFS GSGSGNSYSL TISSVEAEDD ATYYCQQWSK HPLTFGAGTK LEIKAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
207 IL2_SS1 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
208 GM-CSF_SS1 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPELEK PGASVKLSCK ASGYSFTGYT MNWVKQSHGK SLEWIGLITP YNGASSYNQK FRGKATLTVD KSSSTAYMDL LSLTSEDSAV YFCARGGYDG RGFDYWGQGT TVTVSSGGGG SGGGGSGGGG SDIELTQSPA IMSASPGEKV TMTCSASSSV SYMHWYQQKS GTSPKRWIYD TSKLASGVPG RFSGSGSGNS YSLTISSVEA EDDATYYCQQ WSKHPLTFGA GTKLEIKAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
209 hIgGk-VIII _SS1_CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
210 OSM_M5 _spCD28 _CD28_CD40 CTP225 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVEKPG ASVKVSCKAS GYTFTDYYMH WVRQAPGQGL EWMGWINPNS GGTNYAQKFQ GRVTMTRDTS ISTAYMELSR LRSDDTAVYY CASGWDFDYW GQGTLVTVSS GGGGSGGGGS GGGGSDIVMT QSPSSLSASV GDRVTITCRA SQSIRYYLSW YQQKPGKAPK LLIYTASILQ NGVPSRFSGS GSGTDFTLTI SSLQPEDFAT YYCLQTYTTP DFGPGTKVEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
211 CD8a_M5 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVEKPGASVK VSCKASGYTF TDYYMHWVRQ APGQGLEWMG WINPNSGGTN YAQKFQGRVT MTRDTSISTA YMELSRLRSD DTAVYYCASG WDFDYWGQGT LVTVSSGGGG SGGGGSGGGG SDIVMTQSPS SLSASVGDRV TITCRASQSI RYYLSWYQQK PGKAPKLLIY TASILQNGVP SRFSGSGSGT DFTLTISSLQ PEDFATYYCL QTYTTPDFGP GTKVEIKAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
212 CD2_M5 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVEKPGA SVKVSCKASG YTFTDYYMHW VRQAPGQGLE WMGWINPNSG GTNYAQKFQG RVTMTRDTSI STAYMELSRL RSDDTAVYYC ASGWDFDYWG QGTLVTVSSG GGGSGGGGSG GGGSDIVMTQ SPSSLSASVG DRVTITCRAS QSIRYYLSWY QQKPGKAPKL LIYTASILQN GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCLQTYTTPD FGPGTKVEIK AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
213 IL2_M5 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
214 GM-CSF_M5 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVEK PGASVKVSCK ASGYTFTDYY MHWVRQAPGQ GLEWMGWINP NSGGTNYAQK FQGRVTMTRD TSISTAYMEL SRLRSDDTAV YYCASGWDFD YWGQGTLVTV SSGGGGSGGG GSGGGGSDIV MTQSPSSLSA SVGDRVTITC RASQSIRYYL SWYQQKPGKA PKLLIYTASI LQNGVPSRFS GSGSGTDFTL TISSLQPEDF ATYYCLQTYT TPDFGPGTKV EIKAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
215 hIgGk-VIII _M5 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
216 OSM_M5_spCD8 _CD28_CD40 CTP237 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVEKPG ASVKVSCKAS GYTFTDYYMH WVRQAPGQGL EWMGWINPNS GGTNYAQKFQ GRVTMTRDTS ISTAYMELSR LRSDDTAVYY CASGWDFDYW GQGTLVTVSS GGGGSGGGGS GGGGSDIVMT QSPSSLSASV GDRVTITCRA SQSIRYYLSW YQQKPGKAPK LLIYTASILQ NGVPSRFSGS GSGTDFTLTI SSLQPEDFAT YYCLQTYTTP DFGPGTKVEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
217 CD8a_M5_spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVEKPGASVK VSCKASGYTF TDYYMHWVRQ APGQGLEWMG WINPNSGGTN YAQKFQGRVT MTRDTSISTA YMELSRLRSD DTAVYYCASG WDFDYWGQGT LVTVSSGGGG SGGGGSGGGG SDIVMTQSPS SLSASVGDRV TITCRASQSI RYYLSWYQQK PGKAPKLLIY TASILQNGVP SRFSGSGSGT DFTLTISSLQ PEDFATYYCL QTYTTPDFGP GTKVEIKAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
218 CD2_M5_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVEKPGA SVKVSCKASG YTFTDYYMHW VRQAPGQGLE WMGWINPNSG GTNYAQKFQG RVTMTRDTSI STAYMELSRL RSDDTAVYYC ASGWDFDYWG QGTLVTVSSG GGGSGGGGSG GGGSDIVMTQ SPSSLSASVG DRVTITCRAS QSIRYYLSWY QQKPGKAPKL LIYTASILQN GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCLQTYTTPD FGPGTKVEIK AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
219 IL2_M5_spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
220 GM-CSF_M5_spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVEK PGASVKVSCK ASGYTFTDYY MHWVRQAPGQ GLEWMGWINP NSGGTNYAQK FQGRVTMTRD TSISTAYMEL SRLRSDDTAV YYCASGWDFD YWGQGTLVTV SSGGGGSGGG GSGGGGSDIV MTQSPSSLSA SVGDRVTITC RASQSIRYYL SWYQQKPGKA PKLLIYTASI LQNGVPSRFS GSGSGTDFTL TISSLQPEDF ATYYCLQTYT TPDFGPGTKV EIKAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
221 hIgGk-VIII _M5_spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
222 OSM_M5_CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVEKPG ASVKVSCKAS GYTFTDYYMH WVRQAPGQGL EWMGWINPNS GGTNYAQKFQ GRVTMTRDTS ISTAYMELSR LRSDDTAVYY CASGWDFDYW GQGTLVTVSS GGGGSGGGGS GGGGSDIVMT QSPSSLSASV GDRVTITCRA SQSIRYYLSW YQQKPGKAPK LLIYTASILQ NGVPSRFSGS GSGTDFTLTI SSLQPEDFAT YYCLQTYTTP DFGPGTKVEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
223 CD8a_M5_CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVEKPGASVK VSCKASGYTF TDYYMHWVRQ APGQGLEWMG WINPNSGGTN YAQKFQGRVT MTRDTSISTA YMELSRLRSD DTAVYYCASG WDFDYWGQGT LVTVSSGGGG SGGGGSGGGG SDIVMTQSPS SLSASVGDRV TITCRASQSI RYYLSWYQQK PGKAPKLLIY TASILQNGVP SRFSGSGSGT DFTLTISSLQ PEDFATYYCL QTYTTPDFGP GTKVEIKAAA GSGGSGFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
224 CD2_M5_CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVEKPGA SVKVSCKASG YTFTDYYMHW VRQAPGQGLE WMGWINPNSG GTNYAQKFQG RVTMTRDTSI STAYMELSRL RSDDTAVYYC ASGWDFDYWG QGTLVTVSSG GGGSGGGGSG GGGSDIVMTQ SPSSLSASVG DRVTITCRAS QSIRYYLSWY QQKPGKAPKL LIYTASILQN GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCLQTYTTPD FGPGTKVEIK AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
225 IL2_M5_CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
226 GM-CSF_M5 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVEK PGASVKVSCK ASGYTFTDYY MHWVRQAPGQ GLEWMGWINP NSGGTNYAQK FQGRVTMTRD TSISTAYMEL SRLRSDDTAV YYCASGWDFD YWGQGTLVTV SSGGGGSGGG GSGGGGSDIV MTQSPSSLSA SVGDRVTITC RASQSIRYYL SWYQQKPGKA PKLLIYTASI LQNGVPSRFS GSGSGTDFTL TISSLQPEDF ATYYCLQTYT TPDFGPGTKV EIKAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
227 hIgGk-VIII _M5_CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
228 OSM_HN1 _spCD28 _CD28_CD40 CTP226 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKRPG ASVQVSCRAS GYSINTYYMQ WVRQAPGAGL EWMGVINPSG VTSYAQKFQG RVTLTNDTST NTVYMQLNSL TSADTAVYYC ARWALWGDFG MDVWGKGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
229 CD8a_HN1 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKRPGASVQ VSCRASGYSI NTYYMQWVRQ APGAGLEWMG VINPSGVTSY AQKFQGRVTL TNDTSTNTVY MQLNSLTSAD TAVYYCARWA LWGDFGMDVW GKGTLVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
230 CD2_HN1 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKRPGA SVQVSCRASG YSINTYYMQW VRQAPGAGLE WMGVINPSGV TSYAQKFQGR VTLTNDTSTN TVYMQLNSLT SADTAVYYCA RWALWGDFGM DVWGKGTLVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKAAAGS GGSGILVKQS PMLVAYDNAV NLSCKYSYNL FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
231 IL2_HN1 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
232 GM-CSF_HN1 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKR PGASVQVSCR ASGYSINTYY MQWVRQAPGA GLEWMGVINP SGVTSYAQKF QGRVTLTNDT STNTVYMQLN SLTSADTAVY YCARWALWGD FGMDVWGKGT LVTVSSGGGG SGGGGSGGGG SDIQMTQSPS TLSASIGDRV TITCRASEGI YHWLAWYQQK PGKAPKLLIY KASSLASGAP SRFSGSGSGT DFTLTISSLQ PDDFATYYCQ QYSNYPLTFG GGTKLEIKAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
233 hIgGk-VIII _HN1 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
234 OSM_HN1_spCD8 _CD28_CD40 CTP238 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKRPG ASVQVSCRAS GYSINTYYMQ WVRQAPGAGL EWMGVINPSG VTSYAQKFQG RVTLTNDTST NTVYMQLNSL TSADTAVYYC ARWALWGDFG MDVWGKGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
235 CD8a_HN1_spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKRPGASVQ VSCRASGYSI NTYYMQWVRQ APGAGLEWMG VINPSGVTSY AQKFQGRVTL TNDTSTNTVY MQLNSLTSAD TAVYYCARWA LWGDFGMDVW GKGTLVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
236 CD2_HN1_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKRPGA SVQVSCRASG YSINTYYMQW VRQAPGAGLE WMGVINPSGV TSYAQKFQGR VTLTNDTSTN TVYMQLNSLT SADTAVYYCA RWALWGDFGM DVWGKGTLVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKAAAGS GGSGFVPVFL PAKPTTTPAP RPPTPAPTIA SQPLSLRPEA CRPAAGGAVH TRGLDFACDI YIWAPLAGTC GVLLLSLVIT LYCNHRNRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
237 IL2_HN1_spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
238 GM-CSF_HN1 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKR PGASVQVSCR ASGYSINTYY MQWVRQAPGA GLEWMGVINP SGVTSYAQKF QGRVTLTNDT STNTVYMQLN SLTSADTAVY YCARWALWGD FGMDVWGKGT LVTVSSGGGG SGGGGSGGGG SDIQMTQSPS TLSASIGDRV TITCRASEGI YHWLAWYQQK PGKAPKLLIY KASSLASGAP SRFSGSGSGT DFTLTISSLQ PDDFATYYCQ QYSNYPLTFG GGTKLEIKAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
239 hIgGk-VIII _HN1_spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
240 OSM_HN1_CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKRPG ASVQVSCRAS GYSINTYYMQ WVRQAPGAGL EWMGVINPSG VTSYAQKFQG RVTLTNDTST NTVYMQLNSL TSADTAVYYC ARWALWGDFG MDVWGKGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
241 CD8a_HN1_CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKRPGASVQ VSCRASGYSI NTYYMQWVRQ APGAGLEWMG VINPSGVTSY AQKFQGRVTL TNDTSTNTVY MQLNSLTSAD TAVYYCARWA LWGDFGMDVW GKGTLVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
242 CD2_HN1_CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKRPGA SVQVSCRASG YSINTYYMQW VRQAPGAGLE WMGVINPSGV TSYAQKFQGR VTLTNDTSTN TVYMQLNSLT SADTAVYYCA RWALWGDFGM DVWGKGTLVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKAAAGS GGSGFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
243 IL2_HN1_CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
244 GM-CSF_HN1 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKR PGASVQVSCR ASGYSINTYY MQWVRQAPGA GLEWMGVINP SGVTSYAQKF QGRVTLTNDT STNTVYMQLN SLTSADTAVY YCARWALWGD FGMDVWGKGT LVTVSSGGGG SGGGGSGGGG SDIQMTQSPS TLSASIGDRV TITCRASEGI YHWLAWYQQK PGKAPKLLIY KASSLASGAP SRFSGSGSGT DFTLTISSLQ PDDFATYYCQ QYSNYPLTFG GGTKLEIKAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
245 hIgGk-VIII _HN1_CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
246 OSM_M912 _spCD28 _CD28_CD40 CTP227 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ ESGPGLVKPS ETLSLTCTVS GGSVSSGSYY WSWIRQPPGK GLEWIGYIYY SGSTNYNPSL KSRVTISVDT SKNQFSLKLS SVTAADTAVY YCAREGKNGA FDIWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCRASQSISS YLNWYQQKPG KAPKLLIYAA SSLQSGVPSG FSGSGSGTDF TLTISSLQPE DFATYYCQQS YSTPLTFGGG TKVEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
247 CD8a_M912 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQESGP GLVKPSETLS LTCTVSGGSV SSGSYYWSWI RQPPGKGLEW IGYIYYSGST NYNPSLKSRV TISVDTSKNQ FSLKLSSVTA ADTAVYYCAR EGKNGAFDIW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA SQSISSYLNW YQQKPGKAPK LLIYAASSLQ SGVPSGFSGS GSGTDFTLTI SSLQPEDFAT YYCQQSYSTP LTFGGGTKVE IKAAAGSGGS GILVKQSPML VAYDNAVNLS CKYSYNLFSR EFRASLHKGL DSAVEVCVVY GNYSQQLQVY SKTGFNCDGK LGNESVTFYL QNLYVNQTDI YFCKIEVMYP PPYLDNEKSN GTIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
248 CD2_M912 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQE SGPGLVKPSE TLSLTCTVSG GSVSSGSYYW SWIRQPPGKG LEWIGYIYYS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY CAREGKNGAF DIWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQSISSY LNWYQQKPGK APKLLIYAAS SLQSGVPSGF SGSGSGTDFT LTISSLQPED FATYYCQQSY STPLTFGGGT KVEIKAAAGS GGSGILVKQS PMLVAYDNAV NLSCKYSYNL FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
249 IL2_M912 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
250 GM-CSF_M912 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQESGPGLVK PSETLSLTCT VSGGSVSSGS YYWSWIRQPP GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCAREGKN GAFDIWGQGT MVTVSSGGGG SGGGGSGGGG SDIQMTQSPS SLSASVGDRV TITCRASQSI SSYLNWYQQK PGKAPKLLIY AASSLQSGVP SGFSGSGSGT DFTLTISSLQ PEDFATYYCQ QSYSTPLTFG GGTKVEIKAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
251 hIgGk-VIII _M912 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
252 OSM_M912_spCD8 _CD28_CD40 CTP239 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ ESGPGLVKPS ETLSLTCTVS GGSVSSGSYY WSWIRQPPGK GLEWIGYIYY SGSTNYNPSL KSRVTISVDT SKNQFSLKLS SVTAADTAVY YCAREGKNGA FDIWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCRASQSISS YLNWYQQKPG KAPKLLIYAA SSLQSGVPSG FSGSGSGTDF TLTISSLQPE DFATYYCQQS YSTPLTFGGG TKVEIKAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
253 CD8a_M912_spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQESGP GLVKPSETLS LTCTVSGGSV SSGSYYWSWI RQPPGKGLEW IGYIYYSGST NYNPSLKSRV TISVDTSKNQ FSLKLSSVTA ADTAVYYCAR EGKNGAFDIW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA SQSISSYLNW YQQKPGKAPK LLIYAASSLQ SGVPSGFSGS GSGTDFTLTI SSLQPEDFAT YYCQQSYSTP LTFGGGTKVE IKAAAGSGGS GFVPVFLPAK PTTTPAPRPP TPAPTIASQP LSLRPEACRP AAGGAVHTRG LDFACDIYIW APLAGTCGVL LLSLVITLYC NHRNRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
254 CD2_M912_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQE SGPGLVKPSE TLSLTCTVSG GSVSSGSYYW SWIRQPPGKG LEWIGYIYYS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY CAREGKNGAF DIWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQSISSY LNWYQQKPGK APKLLIYAAS SLQSGVPSGF SGSGSGTDFT LTISSLQPED FATYYCQQSY STPLTFGGGT KVEIKAAAGS GGSGFVPVFL PAKPTTTPAP RPPTPAPTIA SQPLSLRPEA CRPAAGGAVH TRGLDFACDI YIWAPLAGTC GVLLLSLVIT LYCNHRNRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
255 IL2_M912_spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
256 GM-CSF _M912_spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQESGPGLVK PSETLSLTCT VSGGSVSSGS YYWSWIRQPP GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCAREGKN GAFDIWGQGT MVTVSSGGGG SGGGGSGGGG SDIQMTQSPS SLSASVGDRV TITCRASQSI SSYLNWYQQK PGKAPKLLIY AASSLQSGVP SGFSGSGSGT DFTLTISSLQ PEDFATYYCQ QSYSTPLTFG GGTKVEIKAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
257 hIgGk-VIII _M912_spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
258 OSM_M912 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ ESGPGLVKPS ETLSLTCTVS GGSVSSGSYY WSWIRQPPGK GLEWIGYIYY SGSTNYNPSL KSRVTISVDT SKNQFSLKLS SVTAADTAVY YCAREGKNGA FDIWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCRASQSISS YLNWYQQKPG KAPKLLIYAA SSLQSGVPSG FSGSGSGTDF TLTISSLQPE DFATYYCQQS YSTPLTFGGG TKVEIKAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
259 CD8a_M912 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQESGP GLVKPSETLS LTCTVSGGSV SSGSYYWSWI RQPPGKGLEW IGYIYYSGST NYNPSLKSRV TISVDTSKNQ FSLKLSSVTA ADTAVYYCAR EGKNGAFDIW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA SQSISSYLNW YQQKPGKAPK LLIYAASSLQ SGVPSGFSGS GSGTDFTLTI SSLQPEDFAT YYCQQSYSTP LTFGGGTKVE IKAAAGSGGS GFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
260 CD2_M912 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQE SGPGLVKPSE TLSLTCTVSG GSVSSGSYYW SWIRQPPGKG LEWIGYIYYS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY CAREGKNGAF DIWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQSISSY LNWYQQKPGK APKLLIYAAS SLQSGVPSGF SGSGSGTDFT LTISSLQPED FATYYCQQSY STPLTFGGGT KVEIKAAAGS GGSGFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
261 IL2_M912 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
262 GM-CSF_M912 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQESGPGLVK PSETLSLTCT VSGGSVSSGS YYWSWIRQPP GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCAREGKN GAFDIWGQGT MVTVSSGGGG SGGGGSGGGG SDIQMTQSPS SLSASVGDRV TITCRASQSI SSYLNWYQQK PGKAPKLLIY AASSLQSGVP SGFSGSGSGT DFTLTISSLQ PEDFATYYCQ QSYSTPLTFG GGTKVEIKAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
263 hIgGk-VIII _M912 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
264 OSM_HuYP218 _spCD28 _CD28_CD40 CTP228 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFDLGFYFYA CWVRQAPGKG LEWVSCIYTA GSGSTYYASW AKGRFTISRD NSKNTLYLQM NSLRAEDTAV YYCARSTANT RSTYYLNLWG QGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCQAS QRISSYLSWY QQKPGKVPKL LIYGASTLAS GVPSRFSGSG SGTDFTLTIS SLQPEDVATY YCQSYAYFDS NNWHAFGGGT KVEIAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
265 CD8a_HuYP218 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFDL GFYFYACWVR QAPGKGLEWV SCIYTAGSGS TYYASWAKGR FTISRDNSKN TLYLQMNSLR AEDTAVYYCA RSTANTRSTY YLNLWGQGTL VTVSSGGGGS GGGGSGGGGS DIQMTQSPSS LSASVGDRVT ITCQASQRIS SYLSWYQQKP GKVPKLLIYG ASTLASGVPS RFSGSGSGTD FTLTISSLQP EDVATYYCQS YAYFDSNNWH AFGGGTKVEI AAAGSGGSGI LVKQSPMLVA YDNAVNLSCK YSYNLFSREF RASLHKGLDS AVEVCVVYGN YSQQLQVYSK TGFNCDGKLG NESVTFYLQN LYVNQTDIYF CKIEVMYPPP YLDNEKSNGT IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
266 CD2_HuYP218 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FDLGFYFYAC WVRQAPGKGL EWVSCIYTAG SGSTYYASWA KGRFTISRDN SKNTLYLQMN SLRAEDTAVY YCARSTANTR STYYLNLWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQMTQS PSSLSASVGD RVTITCQASQ RISSYLSWYQ QKPGKVPKLL IYGASTLASG VPSRFSGSGS GTDFTLTISS LQPEDVATYY CQSYAYFDSN NWHAFGGGTK VEIAAAGSGG SGILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
267 IL2_HuYP218 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
268 GM-CSF_HuYP218 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFDLGFYF YACWVRQAPG KGLEWVSCIY TAGGSTYYA SWAKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCARSTA NTRSTYYLNL WGQGTLVTVS SGGGGSGGGG SGGGGSDIQM TQSPSSLSAS VGDRVTITCQ ASQRISSYLS WYQQKPGKVP KLLIYGASTL ASGVPSRFSG SGSGTDFTLT ISSLQPEDVA TYYCQSYAYF DSNNWHAFGG GTKVEIAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
269 hIgGk-VIII _HuYP218 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
270 OSM_HuYP218 _spCD8 _CD28_CD40 CTP240 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFDLGFYFYA CWVRQAPGKG LEWVSCIYTA GSGSTYYASW AKGRFTISRD NSKNTLYLQM NSLRAEDTAV YYCARSTANT RSTYYLNLWG QGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCQAS QRISSYLSWY QQKPGKVPKL LIYGASTLAS GVPSRFSGSG SGTDFTLTIS SLQPEDVATY YCQSYAYFDS NNWHAFGGGT KVEIAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
271 CD8a_HuYP218 _spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFDL GFYFYACWVR QAPGKGLEWV SCIYTAGSGS TYYASWAKGR FTISRDNSKN TLYLQMNSLR AEDTAVYYCA RSTANTRSTY YLNLWGQGTL VTVSSGGGGS GGGGSGGGGS DIQMTQSPSS LSASVGDRVT ITCQASQRIS SYLSWYQQKP GKVPKLLIYG ASTLASGVPS RFSGSGSGTD FTLTISSLQP EDVATYYCQS YAYFDSNNWH AFGGGTKVEI AAAGSGGSGF VPVFLPAKPT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP LAGTCGVLLL SLVITLYCNH RNRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
272 CD2_HuYP218 _spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FDLGFYFYAC WVRQAPGKGL EWVSCIYTAG SGSTYYASWA KGRFTISRDN SKNTLYLQMN SLRAEDTAVY YCARSTANTR STYYLNLWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQMTQS PSSLSASVGD RVTITCQASQ RISSYLSWYQ QKPGKVPKLL IYGASTLASG VPSRFSGSGS GTDFTLTISS LQPEDVATYY CQSYAYFDSN NWHAFGGGTK VEIAAAGSGG SGFVPVFLPA KPTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR GLDFACDIYI WAPLAGTCGV LLLSLVITLY CNHRNRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
273 IL2_HuYP218 _spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
274 GM-CSF _HuYP218 _spCD8 _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFDLGFYF YACWVRQAPG KGLEWVSCIY TAGGSTYYA SWAKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCARSTA NTRSTYYLNL WGQGTLVTVS SGGGGSGGGG SGGGGSDIQM TQSPSSLSAS VGDRVTITCQ ASQRISSYLS WYQQKPGKVP KLLIYGASTL ASGVPSRFSG SGSGTDFTLT ISSLQPEDVA TYYCQSYAYF DSNNWHAFGG GTKVEIAAAG SGGSGFVPVF LPAKPTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT CGVLLLSLVI TLYCNHRNRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
275 hIgGk-VIII _HuYP218 _spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
276 OSM_HuYP218 _CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFDLGFYFYA CWVRQAPGKG LEWVSCIYTA GSGSTYYASW AKGRFTISRD NSKNTLYLQM NSLRAEDTAV YYCARSTANT RSTYYLNLWG QGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCQAS QRISSYLSWY QQKPGKVPKL LIYGASTLAS GVPSRFSGSG SGTDFTLTIS SLQPEDVATY YCQSYAYFDS NNWHAFGGGT KVEIAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
277 CD8a_HuYP218 _CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFDL GFYFYACWVR QAPGKGLEWV SCIYTAGSGS TYYASWAKGR FTISRDNSKN TLYLQMNSLR AEDTAVYYCA RSTANTRSTY YLNLWGQGTL VTVSSGGGGS GGGGSGGGGS DIQMTQSPSS LSASVGDRVT ITCQASQRIS SYLSWYQQKP GKVPKLLIYG ASTLASGVPS RFSGSGSGTD FTLTISSLQP EDVATYYCQS YAYFDSNNWH AFGGGTKVEI AAAGSGGSGF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
278 CD2_HuYP218 _CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FDLGFYFYAC WVRQAPGKGL EWVSCIYTAG SGSTYYASWA KGRFTISRDN SKNTLYLQMN SLRAEDTAVY YCARSTANTR STYYLNLWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQMTQS PSSLSASVGD RVTITCQASQ RISSYLSWYQ QKPGKVPKLL IYGASTLASG VPSRFSGSGS GTDFTLTISS LQPEDVATYY CQSYAYFDSN NWHAFGGGTK VEIAAAGSGG SGFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
279 IL2_HuYP218 _CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
280 GM-CSF_HuYP218 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFDLGFYF YACWVRQAPG KGLEWVSCIY TAGGSTYYA SWAKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCARSTA NTRSTYYLNL WGQGTLVTVS SGGGGSGGGG SGGGGSDIQM TQSPSSLSAS VGDRVTITCQ ASQRISSYLS WYQQKPGKVP KLLIYGASTL ASGVPSRFSG SGSGTDFTLT ISSLQPEDVA TYYCQSYAYF DSNNWHAFGG GTKVEIAAAG SGGSGFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
281 hIgGk-VIII _HuYP218 _CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
282 OSM_P4 _spCD28 _CD28_CD40 CTP229 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPGLVTPS QTLSLTCAIS GDSVSSNSAT WNWIRQSPSR GLEWLGRTYY RSKWYNDYAV SVKSRMSINP DTSKNQFSLQ LNSVTPEDTA VYYCARGMMT YYYGMDVWGQ GTTVTVSSGG GGSGGGGSGG GGSQPVLTQS SSLSASPGAS ASLTCTLRSG INVGPYRIYW YQQKPGSPPQ YLLNYKSDSD KQQGSGVPSR FSGSKDASAN AGVLLISGLR SEDEADYYCM IWHSSAAVFG GGTQLTVLSA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
283 CD8a_P4 _spCD28 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP GLVTPSQTLS LTCAISGDSV SSNSATWNWI RQSPSRGLEW LGRTYYRSKW YNDYAVSVKS RMSINPDTSK NQFSLQLNSV TPEDTAVYYC ARGMMTYYYG MDVWGQGTTV TVSSGGGGSG GGGSGGGGSQ PVLTQSSSLS ASPGASASLT CTLRSGINVG PYRIYWYQQK PGSPPQYLLN YKSDSDKQQG SGVPSRFSGS KDASANAGVL LISGLRSEDE ADYYCMIWHS SAAVFGGGTQ LTVLSAAAGS GGSGILVKQS PMLVAYDNAV NLSCKYSYNL FSREFRASLH KGLDSAVEVC VVYGNYSQQL QVYSKTGFNC DGKLGNESVT FYLQNLYVNQ TDIYFCKIEV MYPPPYLDNE KSNGTIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
284 CD2_P4 _spCD28 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPGLVTPSQ TLSLTCAISG DSVSSNSATW NWIRQSPSRG LEWLGRTYYR SKWYNDYAVS VKSRMSINPD TSKNQFSLQL NSVTPEDTAV YYCARGMMTY YYGMDVWGQG TTVTVSSGGG GSGGGGSGGG GSQPVLTQSS SLSASPGASA SLTCTLRSGI NVGPYRIYWY QQKPGSPPQY LLNYKSDSDK QQGSGVPSRF SGSKDASANA GVLLISGLRS EDEADYYCMI WHSSAAVFGG GTQLTVLSAA AGSGGSGILV KQSPMLVAYD NAVNLSCKYS YNLFSREFRA SLHKGLDSAV EVCVVYGNYS QQLQVYSKTG FNCDGKLGNE SVTFYLQNLY VNQTDIYFCK IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
285 IL2_P4 _spCD28 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
286 GM-CSF_P4 _spCD28 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPGLVT PSQTLSLTCA ISGDSVSSNS ATWNWIRQSP SRGLEWLGRT YYRSKWYNDY AVSVKSRMSI NPDTSKNQFS LQLNSVTPED TAVYYCARGM MTYYYGMDVW GQGTTVTVSS GGGGSGGGGS GGGGSQPVLT QSSSLSASPG ASASLTCTLR SGINVGPYRI YWYQQKPGSP PQYLLNYKSD SDKQQGSGVP SRFSGSKDAS ANAGVLLISG LRSEDEADYY CMIWHSSAAV FGGGTQLTVL SAAAGSGGSG ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
287 hIgGk-VIII _P4 _spCD28 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
288 OSM_P4_spCD8 _CD28_CD40 CTP241 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPGLVTPS QTLSLTCAIS GDSVSSNSAT WNWIRQSPSR GLEWLGRTYY RSKWYNDYAV SVKSRMSINP DTSKNQFSLQ LNSVTPEDTA VYYCARGMMT YYYGMDVWGQ GTTVTVSSGG GGSGGGGSGG GGSQPVLTQS SSLSASPGAS ASLTCTLRSG INVGPYRIYW YQQKPGSPPQ YLLNYKSDSD KQQGSGVPSR FSGSKDASAN AGVLLISGLR SEDEADYYCM IWHSSAAVFG GGTQLTVLSA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
289 CD8a_P4_spCD8 _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP GLVTPSQTLS LTCAISGDSV SSNSATWNWI RQSPSRGLEW LGRTYYRSKW YNDYAVSVKS RMSINPDTSK NQFSLQLNSV TPEDTAVYYC ARGMMTYYYG MDVWGQGTTV TVSSGGGGSG GGGSGGGGSQ PVLTQSSSLS ASPGASASLT CTLRSGINVG PYRIYWYQQK PGSPPQYLLN YKSDSDKQQG SGVPSRFSGS KDASANAGVL LISGLRSEDE ADYYCMIWHS SAAVFGGGTQ LTVLSAAAGS GGSGFVPVFL PAKPTTTPAP RPPTPAPTIA SQPLSLRPEA CRPAAGGAVH TRGLDFACDI YIWAPLAGTC GVLLLSLVIT LYCNHRNRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
290 CD2_P4_spCD8 _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPGLVTPSQ TLSLTCAISG DSVSSNSATW NWIRQSPSRG LEWLGRTYYR SKWYNDYAVS VKSRMSINPD TSKNQFSLQL NSVTPEDTAV YYCARGMMTY YYGMDVWGQG TTVTVSSGGG GSGGGGSGGG GSQPVLTQSS SLSASPGASA SLTCTLRSGI NVGPYRIYWY QQKPGSPPQY LLNYKSDSDK QQGSGVPSRF SGSKDASANA GVLLISGLRS EDEADYYCMI WHSSAAVFGG GTQLTVLSAA AGSGGSGFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
291 IL2_P4_spCD8 _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
292 GM-CSF_P4_spCD8 _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPGLVT PSQTLSLTCA ISGDSVSSNS ATWNWIRQSP SRGLEWLGRT YYRSKWYNDY AVSVKSRMSI NPDTSKNQFS LQLNSVTPED TAVYYCARGM MTYYYGMDVW GQGTTVTVSS GGGGSGGGGS GGGGSQPVLT QSSSLSASPG ASASLTCTLR SGINVGPYRI YWYQQKPGSP PQYLLNYKSD SDKQQGSGVP SRFSGSKDAS ANAGVLLISG LRSEDEADYY CMIWHSSAAV FGGGTQLTVL SAAAGSGGSG FVPVFLPAKP TTTPAPRPPT PAPTIASQPL SLRPEACRPA AGGAVHTRGL DFACDIYIWA PLAGTCGVLL LSLVITLYCN HRNRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
293 hIgGk-VIII _P4_spCD8 _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGFVPVFLP AKPTTTPAPR PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL YCNHRNRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
294 OSM_P4_CD28TM _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPGLVTPS QTLSLTCAIS GDSVSSNSAT WNWIRQSPSR GLEWLGRTYY RSKWYNDYAV SVKSRMSINP DTSKNQFSLQ LNSVTPEDTA VYYCARGMMT YYYGMDVWGQ GTTVTVSSGG GGSGGGGSGG GGSQPVLTQS SSLSASPGAS ASLTCTLRSG INVGPYRIYW YQQKPGSPPQ YLLNYKSDSD KQQGSGVPSR FSGSKDASAN AGVLLISGLR SEDEADYYCM IWHSSAAVFG GGTQLTVLSA AAGSGGSGFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
295 CD8a_P4_CD28TM _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP GLVTPSQTLS LTCAISGDSV SSNSATWNWI RQSPSRGLEW LGRTYYRSKW YNDYAVSVKS RMSINPDTSK NQFSLQLNSV TPEDTAVYYC ARGMMTYYYG MDVWGQGTTV TVSSGGGGSG GGGSGGGGSQ PVLTQSSSLS ASPGASASLT CTLRSGINVG PYRIYWYQQK PGSPPQYLLN YKSDSDKQQG SGVPSRFSGS KDASANAGVL LISGLRSEDE ADYYCMIWHS SAAVFGGGTQ LTVLSAAAGS GGSGFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
296 CD2_P4_CD28TM _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPGLVTPSQ TLSLTCAISG DSVSSNSATW NWIRQSPSRG LEWLGRTYYR SKWYNDYAVS VKSRMSINPD TSKNQFSLQL NSVTPEDTAV YYCARGMMTY YYGMDVWGQG TTVTVSSGGG GSGGGGSGGG GSQPVLTQSS SLSASPGASA SLTCTLRSGI NVGPYRIYWY QQKPGSPPQY LLNYKSDSDK QQGSGVPSRF SGSKDASANA GVLLISGLRS EDEADYYCMI WHSSAAVFGG GTQLTVLSAA AGSGGSGFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
297 IL2_P4_CD28TM _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
298 GM-CSF_P4 _CD28TM _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPGLVT PSQTLSLTCA ISGDSVSSNS ATWNWIRQSP SRGLEWLGRT YYRSKWYNDY AVSVKSRMSI NPDTSKNQFS LQLNSVTPED TAVYYCARGM MTYYYGMDVW GQGTTVTVSS GGGGSGGGGS GGGGSQPVLT QSSSLSASPG ASASLTCTLR SGINVGPYRI YWYQQKPGSP PQYLLNYKSD SDKQQGSGVP SRFSGSKDAS ANAGVLLISG LRSEDEADYY CMIWHSSAAV FGGGTQLTVL SAAAGSGGSG FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
299 hIgGk-VIII _P4_CD28TM _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
300 OSM_SS1 _spCD28(trun) _CD28_CD40 CTP248 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPELEKPG ASVKLSCKAS GYSFTGYTMN WVKQSHGKSL EWIGLITPYN GASSYNQKFR GKATLTVDKS SSTAYMDLLS LTSEDSAVYF CARGGYDGRG FDYWGQGTTV TVSSGGGGSG GGGSGGGGSD IELTQSPAIM SASPGEKVTM TCSASSSVSY MHWYQQKSGT SPKRWIYDTS KLASGVPGRF SGSGSGNSYS LTISSVEAED DATYYCQQWS KHPLTFGAGT KLEIKAAAGS GGSGIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
301 CD8a_SS1 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP ELEKPGASVK LSCKASGYSF TGYTMNWVKQ SHGKSLEWIG LITPYNGASS YNQKFRGKAT LTVDKSSSTA YMDLLSLTSE DSAVYFCARG GYDGRGFDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIELT QSPAIMSASP GEKVTMTCSA SSSVSYMHWY QQKSGTSPKR WIYDTSKLAS GVPGRFSGSG SGNSYSLTIS SVEAEDDATY YCQQWSKHPL TFGAGTKLEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
302 CD2_SS1 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPELEKPGA SVKLSCKASG YSFTGYTMNW VKQSHGKSLE WIGLITPYNG ASSYNQKFRG KATLTVDKSS STAYMDLLSL TSEDSAVYFC ARGGYDGRGF DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPAIMS ASPGEKVTMT CSASSSVSYM HWYQQKSGTS PKRWIYDTSK LASGVPGRFS GSGSGNSYSL TISSVEAEDD ATYYCQQWSK HPLTFGAGTK LEIKAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
303 IL2_SS1 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
304 GM-CSF_SS1 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPELEK PGASVKLSCK ASGYSFTGYT MNWVKQSHGK SLEWIGLITP YNGASSYNQK FRGKATLTVD KSSSTAYMDL LSLTSEDSAV YFCARGGYDG RGFDYWGQGT TVTVSSGGGG SGGGGSGGGG SDIELTQSPA IMSASPGEKV TMTCSASSSV SYMHWYQQKS GTSPKRWIYD TSKLASGVPG RFSGSGSGNS YSLTISSVEA EDDATYYCQQ WSKHPLTFGA GTKLEIKAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
305 hIgGk-VIII _SS1 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
306 OSM_M5 _spCD28(trun) _CD28_CD40 CTP249 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVEKPG ASVKVSCKAS GYTFTDYYMH WVRQAPGQGL EWMGWINPNS GGTNYAQKFQ GRVTMTRDTS ISTAYMELSR LRSDDTAVYY CASGWDFDYW GQGTLVTVSS GGGGSGGGGS GGGGSDIVMT QSPSSLSASV GDRVTITCRA SQSIRYYLSW YQQKPGKAPK LLIYTASILQ NGVPSRFSGS GSGTDFTLTI SSLQPEDFAT YYCLQTYTTP DFGPGTKVEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
307 CD8a_M5 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVEKPGASVK VSCKASGYTF TDYYMHWVRQ APGQGLEWMG WINPNSGGTN YAQKFQGRVT MTRDTSISTA YMELSRLRSD DTAVYYCASG WDFDYWGQGT LVTVSSGGGG SGGGGSGGGG SDIVMTQSPS SLSASVGDRV TITCRASQSI RYYLSWYQQK PGKAPKLLIY TASILQNGVP SRFSGSGSGT DFTLTISSLQ PEDFATYYCL QTYTTPDFGP GTKVEIKAAA GSGGSGIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
308 CD2_M5 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVEKPGA SVKVSCKASG YTFTDYYMHW VRQAPGQGLE WMGWINPNSG GTNYAQKFQG RVTMTRDTSI STAYMELSRL RSDDTAVYYC ASGWDFDYWG QGTLVTVSSG GGGSGGGGSG GGGSDIVMTQ SPSSLSASVG DRVTITCRAS QSIRYYLSWY QQKPGKAPKL LIYTASILQN GVPSRFSGSG SGTDFTLTIS SLQPEDFATY YCLQTYTTPD FGPGTKVEIK AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
309 IL2_M5 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
310 GM-CSF_M5 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVEK PGASVKVSCK ASGYTFTDYY MHWVRQAPGQ GLEWMGWINP NSGGTNYAQK FQGRVTMTRD TSISTAYMEL SRLRSDDTAV YYCASGWDFD YWGQGTLVTV SSGGGGSGGG GSGGGGSDIV MTQSPSSLSA SVGDRVTITC RASQSIRYYL SWYQQKPGKA PKLLIYTASI LQNGVPSRFS GSGSGTDFTL TISSLQPEDF ATYYCLQTYT TPDFGPGTKV EIKAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
311 hIgGk-VIII _M5 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIKAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
312 OSM_HN1 _spCD28(trun) _CD28_CD40 CTP250 MGVLLTQRTL LSLVLALLFP SMASMQVQLV QSGAEVKRPG ASVQVSCRAS GYSINTYYMQ WVRQAPGAGL EWMGVINPSG VTSYAQKFQG RVTLTNDTST NTVYMQLNSL TSADTAVYYC ARWALWGDFG MDVWGKGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSTL SASIGDRVTI TCRASEGIYH WLAWYQQKPG KAPKLLIYKA SSLASGAPSR FSGSGSGTDF TLTISSLQPD DFATYYCQQY SNYPLTFGGG TKLEIKAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
313 CD8a_HN1 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLVQSGA EVKRPGASVQ VSCRASGYSI NTYYMQWVRQ APGAGLEWMG VINPSGVTSY AQKFQGRVTL TNDTSTNTVY MQLNSLTSAD TAVYYCARWA LWGDFGMDVW GKGTLVTVSS GGGGSGGGGS GGGGSDIQMT QSPSTLSASI GDRVTITCRA SEGIYHWLAW YQQKPGKAPK LLIYKASSLA SGAPSRFSGS GSGTDFTLTI SSLQPDDFAT YYCQQYSNYP LTFGGGTKLE IKAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
314 CD2_HN1 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLVQ SGAEVKRPGA SVQVSCRASG YSINTYYMQW VRQAPGAGLE WMGVINPSGV TSYAQKFQGR VTLTNDTSTN TVYMQLNSLT SADTAVYYCA RWALWGDFGM DVWGKGTLVT VSSGGGGSGG GGSGGGGSDI QMTQSPSTLS ASIGDRVTIT CRASEGIYHW LAWYQQKPGK APKLLIYKAS SLASGAPSRF SGSGSGTDFT LTISSLQPDD FATYYCQQYS NYPLTFGGGT KLEIKAAAGS GGSGIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
315 IL2_HN1 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
316 GM-CSF_HN1 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LVQSGAEVKR PGASVQVSCR ASGYSINTYY MQWVRQAPGA GLEWMGVINP SGVTSYAQKF QGRVTLTNDT STNTVYMQLN SLTSADTAVY YCARWALWGD FGMDVWGKGT LVTVSSGGGG SGGGGSGGGG SDIQMTQSPS TLSASIGDRV TITCRASEGI YHWLAWYQQK PGKAPKLLIY KASSLASGAP SRFSGSGSGT DFTLTISSLQ PDDFATYYCQ QYSNYPLTFG GGTKLEIKAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
317 hIgGk-VIII _HN1 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
318 OSM_M912 _spCD28(trun) _CD28_CD40 CTP251 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ ESGPGLVKPS ETLSLTCTVS GGSVSSGSYY WSWIRQPPGK GLEWIGYIYY SGSTNYNPSL KSRVTISVDT SKNQFSLKLS SVTAADTAVY YCAREGKNGA FDIWGQGTMV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCRASQSISS YLNWYQQKPG KAPKLLIYAA SSLQSGVPSG FSGSGSGTDF TLTISSLQPE DFATYYCQQS YSTPLTFGGG TKVEIKAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
319 CD8a_M912 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQESGP GLVKPSETLS LTCTVSGGSV SSGSYYWSWI RQPPGKGLEW IGYIYYSGST NYNPSLKSRV TISVDTSKNQ FSLKLSSVTA ADTAVYYCAR EGKNGAFDIW GQGTMVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA SQSISSYLNW YQQKPGKAPK LLIYAASSLQ SGVPSGFSGS GSGTDFTLTI SSLQPEDFAT YYCQQSYSTP LTFGGGTKVE IKAAAGSGGS GIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
320 CD2_M912 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQE SGPGLVKPSE TLSLTCTVSG GSVSSGSYYW SWIRQPPGKG LEWIGYIYYS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY CAREGKNGAF DIWGQGTMVT VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQSISSY LNWYQQKPGK APKLLIYAAS SLQSGVPSGF SGSGSGTDFT LTISSLQPED FATYYCQQSY STPLTFGGGT KVEIKAAAGS GGSGIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
321 IL2_M912 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
322 GM-CSF_M912 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQESGPGLVK PSETLSLTCT VSGGSVSSGS YYWSWIRQPP GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCAREGKN GAFDIWGQGT MVTVSSGGGG SGGGGSGGGG SDIQMTQSPS SLSASVGDRV TITCRASQSI SSYLNWYQQK PGKAPKLLIY AASSLQSGVP SGFSGSGSGT DFTLTISSLQ PEDFATYYCQ QSYSTPLTFG GGTKVEIKAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
323 hIgGk-VIII _M912 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI KAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
324 OSM_HuYP218 _spCD28(trun) _CD28_CD40 CTP252 MGVLLTQRTL LSLVLALLFP SMASMEVQLV ESGGGLVQPG GSLRLSCAAS GFDLGFYFYA CWVRQAPGKG LEWVSCIYTA GSGSTYYASW AKGRFTISRD NSKNTLYLQM NSLRAEDTAV YYCARSTANT RSTYYLNLWG QGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCQAS QRISSYLSWY QQKPGKVPKL LIYGASTLAS GVPSRFSGSG SGTDFTLTIS SLQPEDVATY YCQSYAYFDS NNWHAFGGGT KVEIAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
325 CD8a_HuYP218 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PEVQLVESGG GLVQPGGSLR LSCAASGFDL GFYFYACWVR QAPGKGLEWV SCIYTAGSGS TYYASWAKGR FTISRDNSKN TLYLQMNSLR AEDTAVYYCA RSTANTRSTY YLNLWGQGTL VTVSSGGGGS GGGGSGGGGS DIQMTQSPSS LSASVGDRVT ITCQASQRIS SYLSWYQQKP GKVPKLLIYG ASTLASGVPS RFSGSGSGTD FTLTISSLQP EDVATYYCQS YAYFDSNNWH AFGGGTKVEI AAAGSGGSGI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
326 CD2_HuYP218 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSEVQLVE SGGGLVQPGG SLRLSCAASG FDLGFYFYAC WVRQAPGKGL EWVSCIYTAG SGSTYYASWA KGRFTISRDN SKNTLYLQMN SLRAEDTAVY YCARSTANTR STYYLNLWGQ GTLVTVSSGG GGSGGGGSGG GGSDIQMTQS PSSLSASVGD RVTITCQASQ RISSYLSWYQ QKPGKVPKLL IYGASTLASG VPSRFSGSGS GTDFTLTISS LQPEDVATYY CQSYAYFDSN NWHAFGGGTK VEIAAAGSGG SGIIHVKGKH LCPSPLFPGP SKPFWVLVVV GGVLACYSLL VTVAFIIFWV RSKRSRLLHS DYMNMTPRRP GPTRKHYQPY APPRDFAAYR SKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
327 IL2_HuYP218 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
328 GM-CSF_HuYP218 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISEVQ LVESGGGLVQ PGGSLRLSCA ASGFDLGFYF YACWVRQAPG KGLEWVSCIY TAGGSTYYA SWAKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCARSTA NTRSTYYLNL WGQGTLVTVS SGGGGSGGGG SGGGGSDIQM TQSPSSLSAS VGDRVTITCQ ASQRISSYLS WYQQKPGKVP KLLIYGASTL ASGVPSRFSG SGSGTDFTLT ISSLQPEDVA TYYCQSYAYF DSNNWHAFGG GTKVEIAAAG SGGSGIIHVK GKHLCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
329 hIgGk-VIII _HuYP218 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEIA AAGSGGSGII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
330 OSM_P4 _spCD28(trun) _CD28_CD40 CTP253 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGPGLVTPS QTLSLTCAIS GDSVSSNSAT WNWIRQSPSR GLEWLGRTYY RSKWYNDYAV SVKSRMSINP DTSKNQFSLQ LNSVTPEDTA VYYCARGMMT YYYGMDVWGQ GTTVTVSSGG GGSGGGGSGG GGSQPVLTQS SSLSASPGAS ASLTCTLRSG INVGPYRIYW YQQKPGSPPQ YLLNYKSDSD KQQGSGVPSR FSGSKDASAN AGVLLISGLR SEDEADYYCM IWHSSAAVFG GGTQLTVLSA AAGSGGSGII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRSKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
331 CD8a_P4 _spCD28(trun) _CD28_CD40 MALPVTALLL PLALLLHAAR PQVQLQQSGP GLVTPSQTLS LTCAISGDSV SSNSATWNWI RQSPSRGLEW LGRTYYRSKW YNDYAVSVKS RMSINPDTSK NQFSLQLNSV TPEDTAVYYC ARGMMTYYYG MDVWGQGTTV TVSSGGGGSG GGGSGGGGSQ PVLTQSSSLS ASPGASASLT CTLRSGINVG PYRIYWYQQK PGSPPQYLLN YKSDSDKQQG SGVPSRFSGS KDASANAGVL LISGLRSEDE ADYYCMIWHS SAAVFGGGTQ LTVLSAAAGS GGSGIIHVKG KHLCPSPLFP GPSKPFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
332 CD2_P4 _spCD28(trun) _CD28_CD40 MSFPCKFVAS FLLIFNVSSK GAVSQVQLQQ SGPGLVTPSQ TLSLTCAISG DSVSSNSATW NWIRQSPSRG LEWLGRTYYR SKWYNDYAVS VKSRMSINPD TSKNQFSLQL NSVTPEDTAV YYCARGMMTY YYGMDVWGQG TTVTVSSGGG GSGGGGSGGG GSQPVLTQSS SLSASPGASA SLTCTLRSGI NVGPYRIYWY QQKPGSPPQY LLNYKSDSDK QQGSGVPSRF SGSKDASANA GVLLISGLRS EDEADYYCMI WHSSAAVFGG GTQLTVLSAA AGSGGSGIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
333 IL2_P4 _spCD28(trun) _CD28_CD40 MYRMQLLSCI ALSLALVTNS QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
334 GM-CSF_P4 _spCD28(trun) _CD28_CD40 MWLQSLLLLG TVACSISQVQ LQQSGPGLVT PSQTLSLTCA ISGDSVSSNS ATWNWIRQSP SRGLEWLGRT YYRSKWYNDY AVSVKSRMSI NPDTSKNQFS LQLNSVTPED TAVYYCARGM MTYYYGMDVW GQGTTVTVSS GGGGSGGGGS GGGGSQPVLT QSSSLSASPG ASASLTCTLR SGINVGPYRI YWYQQKPGSP PQYLLNYKSD SDKQQGSGVP SRFSGSKDAS ANAGVLLISG LRSEDEADYY CMIWHSSAAV FGGGTQLTVL SAAAGSGGSG IIHVKGKHLC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
335 hIgGk-VIII _P4 _spCD28(trun) _CD28_CD40 MEAPAQLLFL LLLWLPDTTR QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLSAAAGSG GSGIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
336 NTRK1 IC結構域 NKCGRRNKFG INRPAVLAPE DGLAMSLHFM TLGGSSLSPT EGKGSGLQGH IIENPQYFSD ACVHHIKRRD IVLKWELGEG AFGKVFLAEC HNLLPEQDKM LVAVKALKEA SESARQDFQR EAELLTMLQH QHIVRFFGVC TEGRPLLMVF EYMRHGDLNR FLRSHGPDAK LLAGGEDVAP GPLGLGQLLA VASQVAAGMV YLAGLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML PIRWMPPESI LYRKFTTESD VWSFGVVLWE IFTYGKQPWY QLSNTEAIDC ITQGRELERP RACPPEVYAI MRGCWQREPQ QRHSIKDVHA RLQALAQAPP VYLDVLG
337 ICOS MKSGLWYFFL FLCRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY MFMRAVNTAK KSRLTDVTL
338 ICOS IC結構域 CWLTKKKYSS SVHDPNGEYM FMRAVNTAKK SRLTDVTL
339 小鼠CD2 RDNETIWGVL GHGITLNIPN FQMTDDIDEV RWVRRGTLVA EFKRKKPPFL ISETYEVLAN GSLKIKKPMM RNDSGTYNVM VYGTNGMTRL EKDLDVRILE RVSKPMIHWE CPNTTLTCAV LQGTDFELKL YQGETLLNSL PQKNMSYQWT NLNAPFKCEA INPVSKESKM EVVNCPEKGL SFYVTVGVGA GGLLLVLLVA LFIFCICKRR KRNRRRKDEE LEIKASRTST VERGPKPHST PAAAAQNSVA LQAPPPPGHH LQTPGHRPLP PGHRTREHQQ KKRPPPSGTQ IHQQKGPPLP RPRVQPKPPC GSGDGVSLPP PN
340 小鼠CD2 IC結構域 KRRKRNRRRK DEELEIKASR TSTVERGPKP HSTPAAAAQN SVALQAPPPP GHHLQTPGHR PLPPGHRTRE HQQKKRPPPS GTQIHQQKGP PLPRPRVQPK PPCGSGDGVS LPPPN
341 CD137 IC結構域 KRGRKKLLYI FKQPFMRPVQ TTQEEDGCSC RFPEEEEGGC EL
342 DAP10 IC結構域 LCARPRRSPA QEDGKVYINM PGRG
343 CD134 IC結構域 ALYLLRRDQR LPPDAHKPPG GGSFRTPIQE EQADAHSTLA KI
344 hMFE23. TMtCD28.NTRK1 CTP313 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVNKCGRR NKFGINRPAV LAPEDGLAMS LHFMTLGGSS LSPTEGKGSG LQGHIIENPQ YFSDACVHHI KRRDIVLKWE LGEGAFGKVF LAECHNLLPE QDKMLVAVKA LKEASESARQ DFQREAELLT MLQHQHIVRF FGVCTEGRPL LMVFEYMRHG DLNRFLRSHG PDAKLLAGGE DVAPGPLGLG QLLAVASQVA AGMVYLAGLH FVHRDLATRN CLVGQGLVVK IGDFGMSRDI YSTDYYRVGG RTMLPIRWMP PESILYRKFT TESDVWSFGV VLWEIFTYGK QPWYQLSNTE AIDCITQGRE LERPRACPPE VYAIMRGCWQ REPQQRHSIK DVHARLQALA QAPPVYLDVLG
345 hMFE23. TMtCD28. NTRK1.CD40 CTP314 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVNKCGRR NKFGINRPAV LAPEDGLAMS LHFMTLGGSS LSPTEGKGSG LQGHIIENPQ YFSDACVHHI KRRDIVLKWE LGEGAFGKVF LAECHNLLPE QDKMLVAVKA LKEASESARQ DFQREAELLT MLQHQHIVRF FGVCTEGRPL LMVFEYMRHG DLNRFLRSHG PDAKLLAGGE DVAPGPLGLG QLLAVASQVA AGMVYLAGLH FVHRDLATRN CLVGQGLVVK IGDFGMSRDI YSTDYYRVGG RTMLPIRWMP PESILYRKFT TESDVWSFGV VLWEIFTYGK QPWYQLSNTE AIDCITQGRE LERPRACPPE VYAIMRGCWQ REPQQRHSIK DVHARLQALA QAPPVYLDVL GKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
346 hMFE23.CD28. tICNTRK1 CTP315 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSNKCGR RNKFGINRPA VLAPEDGLAM SLHFMTLGGS SLSPTEGKGS GLQGHIIENP QYFSDACVHH IKRRDIVLKW ELGEGAFGKV FLAECHNLLP EQDKMLVAVK ALKEASESAR QDFQREAELL TMLQHQHIVR FFGVCTEGRP LLMVFEYMRH GDLNRFLRSH GPDAKLLAGG EDVAPGPLGL GQLLAVASQV AAGMVYLAGL HFVHRDLATR NCLVGQGLVV KIGDFGMSRD IYSTDYYRVG GRTMLPIRWM PPESILYRKF TTESDVWSFG VVLWEIFTYG KQPWYQLSNT EAIDCITQGR ELERPRACPP EVYAIMRGCW QREPQQRHSI KDVHARLQAL AQAPPVYLDV LG
347 hMFE23.CD28. tICNTRK1.CD40 CTP316 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSNKCGR RNKFGINRPA VLAPEDGLAM SLHFMTLGGS SLSPTEGKGS GLQGHIIENP QYFSDACVHH IKRRDIVLKW ELGEGAFGKV FLAECHNLLP EQDKMLVAVK ALKEASESAR QDFQREAELL TMLQHQHIVR FFGVCTEGRP LLMVFEYMRH GDLNRFLRSH GPDAKLLAGG EDVAPGPLGL GQLLAVASQV AAGMVYLAGL HFVHRDLATR NCLVGQGLVV KIGDFGMSRD IYSTDYYRVG GRTMLPIRWM PPESILYRKF TTESDVWSFG VVLWEIFTYG KQPWYQLSNT EAIDCITQGR ELERPRACPP EVYAIMRGCW QREPQQRHSI KDVHARLQAL AQAPPVYLDV LGKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
348 hMFE23. ICOS.CD40 CTP317 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGGEING SANYEMFIFH NGGVQILCKY PDIVQQFKMQ LLKGGQILCD LTKTKGSGNT VSIKSLKFCH SQLSNNSVSF FLYNLDHSHA NYYFCNLSIF DPPPFKVTLT GGYLHIYESQ LCCQLKFWLP IGCAAFVVVC ILGCILICWL TKKKYSSSVH DPNGEYMFMR AVNTAKKSRL TDVTLKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
349 hMFE23. CD28.ICOS CTP318 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSCWLTK KKYSSSVHDP NGEYMFMRAV NTAKKSRLTD VTL
350 hMFE23.CD28. ICOS.CD40 CTP319 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSCWLTK KKYSSSVHDP NGEYMFMRAV NTAKKSRLTD VTLKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
351 hMFE23.CD2.CD40 CTP320 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGRDNET IWGVLGHGIT LNIPNFQMTD DIDEVRWVRR GTLVAEFKRK KPPFLISETY EVLANGSLKI KKPMMRNDSG TYNVMVYGTN GMTRLEKDLD VRILERVSKP MIHWECPNTT LTCAVLQGTD FELKLYQGET LLNSLPQKNM SYQWTNLNAP FKCEAINPVS KESKMEVVNC PEKGLSFYVT VGVGAGGLLL VLLVALFIFC ICKRRKRNRR RKDEELEIKA SRTSTVERGP KPHSTPAAAA QNSVALQAPP PPGHHLQTPG HRPLPPGHRT REHQQKKRPP PSGTQIHQQK GPPLPRPRVQ PKPPCGSGDG VSLPPPNKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
352 hMFE23. CD28.CD2 CTP321 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKRRKR NRRRKDEELE IKASRTSTVE RGPKPHSTPA AAAQNSVALQ APPPPGHHLQ TPGHRPLPPG HRTREHQQKK RPPPSGTQIH QQKGPPLPRP RVQPKPPCGS GDGVSLPPPN
353 hMFE23.CD28. CD40.CD2 CTP322 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQKRR KRNRRRKDEE LEIKASRTST VERGPKPHST PAAAAQNSVA LQAPPPPGHH LQTPGHRPLP PGHRTREHQQ KKRPPPSGTQ IHQQKGPPLP RPRVQPKPPC GSGDGVSLPP PN
354 hMFE23. CD28.CD137 CTP323 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKRGRK KLLYIFKQPF MRPVQTTQEE DGCSCRFPEE EEGGCEL
355 hMFE23.CD28. CD40.CD137 CTP324 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQKRG RKKLLYIFKQ PFMRPVQTTQ EEDGCSCRFP EEEEGGCEL
356 hMFE23.CD28. DAP10 CTP325 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSLCARP RRSPAQEDGK VYINMPGRG
357 hMFE23.CD28. CD40.DAP10 CTP326 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQLCA RPRRSPAQED GKVYINMPGR G
358 hMFE23.CD28. CD134 CTP327 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSALYLL RRDQRLPPDA HKPPGGGSFR TPIQEEQADA HSTLAKI
359 hMFE23.CD28. CD40.CD134 CTP328 MGVLLTQRTL LSLVLALLFP SMASMQVKLE QSGAEVVKPG ASVKLSCKAS GFNIKDSYMH WLRQGPGQRL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS ANTAYLGLSS LRPEDTAVYY CNEGTPTGPY YFDYWGQGTL VTVSSGGGGS GGGGSGGGGS ENVLTQSPSS MSASVGDRVN IACSASSSVS YMHWFQQKPG KSPKLWIYST SNLASGVPSR FSGSGSGTDY SLTISSMQPE DAATYYCQQR SSYPLTFGGG TKLEIKAAAG SGGSGILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQALY LLRRDQRLPP DAHKPPGGGS FRTPIQEEQA DAHSTLAKI
360 PD1_PD1_sCD28TM _CD28_CD40 (單體) CTP189 MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFWVLV VVGGVLACYS LLVTVAFIIF WVRSKRSRLL HSDYMNMTPR RPGPTRKHYQ PYAPPRDFAA YRSKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
361 OSM_MFE23 _spCD28 _CD28_CD40 (SVQE-AVQA) CTP195 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RIAVQARQ
362 OSM_MFE23 _spCD28 _CD28_CD40 (PVQET-AVAEA) CTP196 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA AVAEALHGCQ PVTQEDGKES RISVQERQ
363 OSM_MFE23 _spCD28 _CD28_CD40 (PQEINF-AQAINF) CTP197 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEAQAINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
364 OSM_MFE23 _spCD28 _CD28_CD40 (P227A) CTP198 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAAHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
365 OSM_MFE23 _spCD28_CD28 _CD40 (Q263A) CTP199 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTAEDGKES RISVQERQ
366 OSM_MFE23 _spCD28 _CD28 _CD40 _CD40_CD40 CTP200 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTAEDGKES RISVQERQKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTAEDGK ESRISVQERQ
367 OSM_MFE23 _spCD28_CD28 (PYAPP-AYAA) _CD40 CTP201 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQAYAAPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
368 OSM_MFE23 _spCD28_CD28 (YMNM-FMNM) _CD40 CTP202 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDFMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
369 OSM_MFE23 _spCD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
370 OSM_MFE23 _spCD28 _CD137_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRFSVV KRGRKKLLYI FKQPFMRPVQ TTQEEDGCSC RFPEEEEGGC EKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
371 OSM_MFE23 _spCD28 _CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRRDQR LPPDAHKPPG GGSFRTPIQE EQADAHSTLA KIKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
372 OSM_MFE23 _spCD28 _CD2_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVKRKKQ RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS NKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
373 OSM_MFE23 _spCD28 _GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVQLGLH IWQLRSQCMW PRETQLLLEV PPSTEDARSC QFPEEERGER SAEEKGRLGD LWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
374 OSM_MFE23 _spCD28 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVKLLMI IHDRREFAKF EKEKMNAKWD TGENPIYKSA VTTVVNPKYE GKKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
375 OSM_MFE23 _spCD28 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGILVK QSPMLVAYDN AVNLSCKYSY NLFSREFRAS LHKGLDSAVE VCVVYGNYSQ QLQVYSKTGF NCDGKLGNES VTFYLQNLYV NQTDIYFCKI EVMYPPPYLD NEKSNGTIIH VKGKHLCPSP LFPGPSKPFW VLVVVGGVLA CYSLLVTVAF IIFWVRRRGK TNHYQTTVEK KSLTIYAQVQ KPGPLQKKLD SFPAQDPCTT IYVAATEPVP ESVQETNSIT VYASVTLPES KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
376 OSM_MFE23 _spCD8_CD40 CTP193 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
377 OSM_MFE23 _spCD8 _CD137_CD40 CTP192 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR FSVVKRGRKK LLYIFKQPFM RPVQTTQEED GCSCRFPEEE EGGCEKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
378 OSM_MFE23 _spCD8 _CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR RDQRLPPDAH KPPGGGSFRT PIQEEQADAH STLAKIKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKSR ISVQERQ
379 OSM_MFE23 _spCD8 _CD2_CD40 CTP191 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNK RKKQRSRRND EELETRAHRV ATEERGRKPH QIPASTPQNP ATSQHPPPPP GHRSQAPSHR PPPPGHRVQH QPQKRPPAPS GTQVHQQKGP PLPRPRVQPK PPHGAAENSL SPSSNKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
380 OSM_MFE23 _spCD8 _GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNQ LGLHIWQLRS QCMWPRETQL LLEVPPSTED ARSCQFPEEE RGERSAEEKG RLGDLWVKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
381 OSM_MFE23 _spCD8 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNK LLMIIHDRRE FAKFEKEKMN AKWDTGENPI YKSAVTTVVN PKYEGKKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
382 OSM_MFE23 _spCD8 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR RRGKTNHYQT TVEKKSLTIY AQVQKPGPLQ KKLDSFPAQD PCTTIYVAAT EPVPESVQET NSITVYASVT LPESKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
383 OSM_MFE23 _spIG4 _CD28_CD40 CTP203 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
384 OSM_MFE23 _spIG4_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
385 OSM_MFE23 _spIG4 _CD137_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
386 OSM_MFE23 _spIG4 _CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVRRDQRLP PDAHKPPGGG SFRTPIQEEQ ADAHSTLAKI KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
387 OSM_MFE23 _spIG4 _CD2_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVKRKKQRS RRNDEELETR AHRVATEERG RKPHQIPAST PQNPATSQHP PPPPGHRSQA PSHRPPPPGH RVQHQPQKRP PAPSGTQVHQ QKGPPLPRPR VQPKPPHGAA ENSLSPSSNK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
388 OSM_MFE23 _spIG4 _GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVQLGLHIW QLRSQCMWPR ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW VKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
389 OSM_MFE23 _spIG4 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVKLLMIIH DRREFAKFEK EKMNAKWDTG ENPIYKSAVT TVVNPKYEGK KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
390 OSM_MFE23 _spIG4 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVRRRGKTN HYQTTVEKKS LTIYAQVQKP GPLQKKLDSF PAQDPCTTIY VAATEPVPES VQETNSITVY ASVTLPESKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
391 OSM_MFE23 _spIG4 _CD40_串聯 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQKKVA
392 OSM_MFE23 _spIG4 _CD40_P227A MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGESKY GPPCPSCPAP EFLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV FSCSVMHEAL HNHYTQKSLS LSLGKMFWVL VVVGGVLACY SLLVTVAFII FWVKKVAKKP TNKAAHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
393 OSM_MFE23_PD1 _sCD28TM_CD28 _CD40 CTP204 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGRPGW FLDSPDRPWN PPTFSPALLV VTEGDNATFT CSFSNTSESF VLNWYRMSPS NQTDKLAAFP EDRSQPGQDC RFRVTQLPNG RDFHMSVVRA RRNDSGTYLC GAISLAPKAQ IKESLRAELR VTERRAEVPT AHCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
394 OSM_MFE23_PD1 _sCD28TM_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGRPGW FLDSPDRPWN PPTFSPALLV VTEGDNATFT CSFSNTSESF VLNWYRMSPS NQTDKLAAFP EDRSQPGQDC RFRVTQLPNG RDFHMSVVRA RRNDSGTYLC GAISLAPKAQ IKESLRAELR VTERRAEVPT AHCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
395 OSM_MFE23_TIGIT _sCD28TM_CD28 _CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGMMTG TIETTGNISA EKGGSIILQC HLSSTTAQVT QVNWEQQDQL LAICNADLGW HISPSFKDRV APGPGLGLTL QSLTVNDTGE YFCIYHTYPD GTYTGRIFLE VLESSVAEHG ARFQIPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
396 OSM_MFE23_TIGIT _sCD28TM_CD40    MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGMMTG TIETTGNISA EKGGSIILQC HLSSTTAQVT QVNWEQQDQL LAICNADLGW HISPSFKDRV APGPGLGLTL QSLTVNDTGE YFCIYHTYPD GTYTGRIFLE VLESSVAEHG ARFQIPFWVL VVVGGVLACY SLLVTVAFII FWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
397 OSM_MOV19 _spCD28 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRSK RSRLLHSDYM NMTPRRPGPT RKHYQPYAPP RDFAAYRSKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
398 OSM_MOV19 _spCD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
399 OSM_MOV19 _spCD28 _CD137_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRFS VVKRGRKKLL YIFKQPFMRP VQTTQEEDGC SCRFPEEEEG GCEKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
400 OSM_MOV19 _spCD28 _CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRRD QRLPPDAHKP PGGGSFRTPI QEEQADAHST LAKIKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
401 OSM_MOV19 _spCD28 _CD2_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVKRK KQRSRRNDEE LETRAHRVAT EERGRKPHQI PASTPQNPAT SQHPPPPPGH RSQAPSHRPP PPGHRVQHQP QKRPPAPSGT QVHQQKGPPL PRPRVQPKPP HGAAENSLSP SSNKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
402 OSM_MOV19 _spCD28 _GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVQLG LHIWQLRSQC MWPRETQLLL EVPPSTEDAR SCQFPEEERG ERSAEEKGRL GDLWVKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
403 OSM_MOV19 _spCD28 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVKLL MIIHDRREFA KFEKEKMNAK WDTGENPIYK SAVTTVVNPK YEGKKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
404 OSM_MOV19 _spCD28 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGIL VKQSPMLVAY DNAVNLSCKY SYNLFSREFR ASLHKGLDSA VEVCVVYGNY SQQLQVYSKT GFNCDGKLGN ESVTFYLQNL YVNQTDIYFC KIEVMYPPPY LDNEKSNGTI IHVKGKHLCP SPLFPGPSKP FWVLVVVGGV LACYSLLVTV AFIIFWVRRR GKTNHYQTTV EKKSLTIYAQ VQKPGPLQKK LDSFPAQDPC TTIYVAATEP VPESVQETNS ITVYASVTLP ESKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
405 OSM_MOV19 _spCD8_CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
406 OSM_MOV19 _spCD8_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
407 OSM_MOV19 _spCD8_CD137_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRFSVVKRGR KKLLYIFKQP FMRPVQTTQE EDGCSCRFPE EEEGGCEKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
408 OSM_MOV19 _spCD8_CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRRDQRLPPD AHKPPGGGSF RTPIQEEQAD AHSTLAKIKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK SRISVQERQ
409 OSM_MOV19 _spCD8_CD2_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NKRKKQRSRR NDEELETRAH RVATEERGRK PHQIPASTPQ NPATSQHPPP PPGHRSQAPS HRPPPPGHRV QHQPQKRPPA PSGTQVHQQK GPPLPRPRVQ PKPPHGAAEN SLSPSSNKKV AKKPTNKAPH PKQEPQEINF PDDLPGSNTA APVQETLHGC QPVTQEDGKE SRISVQERQ
410 OSM_MOV19 _spCD8_GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NQLGLHIWQL RSQCMWPRET QLLLEVPPST EDARSCQFPE EERGERSAEE KGRLGDLWVK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
411 OSM_MOV19_spCD8 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NKLLMIIHDR REFAKFEKEK MNAKWDTGEN PIYKSAVTTV VNPKYEGKKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
412 OSM_MOV19_spCD8 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGFV PVFLPAKPTT TPAPRPPTPA PTIASQPLSL RPEACRPAAG GAVHTRGLDF ACDIYIWAPL AGTCGVLLLS LVITLYCNHR NRRRGKTNHY QTTVEKKSLT IYAQVQKPGP LQKKLDSFPA QDPCTTIYVA ATEPVPESVQ ETNSITVYAS VTLPESKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
413 OSM_MOV19_spIG4 _CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
414 OSM_MOV19 _spIG4_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
415 OSM_MOV19_spIG4 _CD137_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
416 OSM_MOV19_spIG4 _CD134_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVRRDQR LPPDAHKPPG GGSFRTPIQE EQADAHSTLA KIKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
417 OSM_MOV19_spIG4 _CD2_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVKRKKQ RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS NKKVAKKPTN KAPHPKQEPQ EINFPDDLPG SNTAAPVQET LHGCQPVTQE DGKESRISVQ ERQ
418 OSM_MOV19_spIG4 _GITR_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVQLGLH IWQLRSQCMW PRETQLLLEV PPSTEDARSC QFPEEERGER SAEEKGRLGD LWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
419 OSM_MOV19_spIG4 _CD29_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVKLLMI IHDRREFAKF EKEKMNAKWD TGENPIYKSA VTTVVNPKYE GKKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
420 OSM_MOV19_spIG4 _CD150_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVRRRGK TNHYQTTVEK KSLTIYAQVQ KPGPLQKKLD SFPAQDPCTT IYVAATEPVP ESVQETNSIT VYASVTLPES KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
421 OSM_MOV19_spIG4 _CD40_串聯 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQKKVA
422 OSM_MOV19_spIG4 _CD40_P227A MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLGKMFW VLVVVGGVLA CYSLLVTVAF IIFWVKKVAK KPTNKAAHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
423 PD1_PD1_sCD28TM _CD28_CD40 (二聚體) CTP188 MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHCPSPL FPGPSKPFWV LVVVGGVLAC YSLLVTVAFI IFWVRSKRSR LLHSDYMNMT PRRPGPTRKH YQPYAPPRDF AAYRSKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
424 PD1_PD1 _sCD28TM_CD40 MQIPQAPWPV VWAVLQLGWR PGWRPGWFLD SPDRPWNPPT FSPALLVVTE GDNATFTCSF SNTSESFVLN WYRMSPSNQT DKLAAFPEDR SQPGQDCRFR VTQLPNGRDF HMSVVRARRN DSGTYLCGAI SLAPKAQIKE SLRAELRVTE RRAEVPTAHC PSPLFPGPSK PFWVLVVVGG VLACYSLLVT VAFIIFWVKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
425 TIGIT_TIGIT _CD28TM _CD28_CD40 MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG RIFLEVLESS VAEHGARFQI PFWVLVVVGG VLACYSLLVT VAFIIFWVRS KRSRLLHSDY MNMTPRRPGP TRKHYQPYAP PRDFAAYRSK KVAKKPTNKA PHPKQEPQEI NFPDDLPGSN TAAPVQETLH GCQPVTQEDG KESRISVQER Q
426 TIGIT_TIGIT _CD28TM_CD40 MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG RIFLEVLESS VAEHGARFQI PFWVLVVVGG VLACYSLLVT VAFIIFWVKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
427 OSM_MOV19_PD1 _sCD28TM_CD28 _CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGRP GWFLDSPDRP WNPPTFSPAL LVVTEGDNAT FTCSFSNTSE SFVLNWYRMS PSNQTDKLAA FPEDRSQPGQ DCRFRVTQLP NGRDFHMSVV RARRNDSGTY LCGAISLAPK AQIKESLRAE LRVTERRAEV PTAHCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVRSKRSRL LHSDYMNMTP RRPGPTRKHY QPYAPPRDFA AYRSKKVAKK PTNKAPHPKQ EPQEINFPDD LPGSNTAAPV QETLHGCQPV TQEDGKESRI SVQERQ
428 OSM_MOV19_PD1 _sCD28TM_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGRP GWFLDSPDRP WNPPTFSPAL LVVTEGDNAT FTCSFSNTSE SFVLNWYRMS PSNQTDKLAA FPEDRSQPGQ DCRFRVTQLP NGRDFHMSVV RARRNDSGTY LCGAISLAPK AQIKESLRAE LRVTERRAEV PTAHCPSPLF PGPSKPFWVL VVVGGVLACY SLLVTVAFII FWVKKVAKKP TNKAPHPKQE PQEINFPDDL PGSNTAAPVQ ETLHGCQPVT QEDGKESRIS VQERQ
429 OSM_MOV19_TIGIT _sCD28TM_CD28 _CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGMM TGTIETTGNI SAEKGGSIIL QCHLSSTTAQ VTQVNWEQQD QLLAICNADL GWHISPSFKD RVAPGPGLGL TLQSLTVNDT GEYFCIYHTY PDGTYTGRIF LEVLESSVAE HGARFQIPFW VLVVVGGVLA CYSLLVTVAF IIFWVRSKRS RLLHSDYMNM TPRRPGPTRK HYQPYAPPRD FAAYRSKKVA KKPTNKAPHP KQEPQEINFP DDLPGSNTAA PVQETLHGCQ PVTQEDGKES RISVQERQ
430 OSM_MOV19_TIGIT _sCD28TM_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVKPG ASVKISCKAS GYSFTGYFMN WVKQSHGKSL EWIGRIHPYD GDTFYNQNFK DKATLTVDKS SNTAHMELLS LTSEDFAVYY CTRYDGSRAM DYWGQGTTVT VSSGGGGSGG GGSGGGGSDI ELTQSPASLA VSLGQRAIIS CKASQSVSFA GTSLMHWYHQ KPGQQPKLLI YRASNLEAGV PTRFSGSGSK TDFTLNIHPV EEEDAATYYC QQSREYPYTF GGGTKLEIKA AAGSGGSGMM TGTIETTGNI SAEKGGSIIL QCHLSSTTAQ VTQVNWEQQD QLLAICNADL GWHISPSFKD RVAPGPGLGL TLQSLTVNDT GEYFCIYHTY PDGTYTGRIF LEVLESSVAE HGARFQIPFW VLVVVGGVLA CYSLLVTVAF IIFWVKKVAK KPTNKAPHPK QEPQEINFPD DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ
431 連接體 GGGGSGGGGS GGGGS
432 截短細胞質結構域CD28變體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKR
433 CD28.CD137融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSRFSVVKRG RKKLLYIFKQ PFMRPVQTTQ EEDGCSCRFP EEEEGGCE
434 CD28.CD134融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSRRDQRLPP DAHKPPGGGS FRTPIQEEQA DAHSTLAKI
435 CD28.CD2融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKRKKQRSR RNDEELETRA HRVATEERGR KPHQIPASTP QNPATSQHPP PPPGHRSQAP SHRPPPPGHR VQHQPQKRPP APSGTQVHQQ KGPPLPRPRV QPKPPHGAAE NSLSPSSN
436 CD28.CD29融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKLLMIIHD RREFAKFEKE KMNAKWDTGE NPIYKSAVTT VVNPKYEGK
437 CD28.GITR融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSQLGLHIWQ LRSQCMWPRE TQLLLEVPPS TEDARSCQFP EEERGERSAE EKGRLGDLWV
438 CD28.IL2Rγ融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSERTMPRIP TLKNLEDLVT EYHGNFSAWS GVSKGLAESL QPDYSERLCL VSEIPPKGGA LGEGPGASPC NQHSPYWAPP CYTLKPET
439 CD28.CD40融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKKVAKKPT NKAPHPKQEP QEINFPDDLP GSNTAAPVQE TLHGCQPVTQ EDGKESRISV QERQ
440 CD28.CD150融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSRRRGKTNH YQTTVEKKSL TIYAQVQKPG PLQKKLDSFP AQDPCTTIYV AATEPVPESV QETNSITVYA SVTLPES
441 CD28.CD2.CD40融合體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEVMY PPPYLDNEKS NGTIIHVKGK HLCPSPLFPG PSKPFWVLVV VGGVLACYSL LVTVAFIIFW VRSKRSRLLH SDYMNMTPRR PGPTRKHYQP YAPPRDFAAY RSKRKKQRSR RNDEELETRA HRVATEERGR KPHQIPASTP QNPATSQHPP PPPGHRSQAP SHRPPPPGHR VQHQPQKRPP APSGTQVHQQ KGPPLPRPRV QPKPPHGAAE NSLSPSSNKK VAKKPTNKAP HPKQEPQEIN FPDDLPGSNT AAPVQETLHG CQPVTQEDGK ESRISVQERQ
442 CD28(IEV)變體 IEVMYPPPYL DNEKSNGTII HVKGKHLCPS PLFPGPSKPF WVLVVVGGVL ACYSLLVTVA FIIFWVRSKR SRLLHSDYMN MTPRRPGPTR KHYQPYAPPR DFAAYRS
443 SH3模體2 PTNKAPHP
444 SH3模體3 PTNKAPH
445 TRAF2_模體4 PKQET
446 TRAF2_模體5 PVQET
447 TRAF2_模體6 SVQET
448 TRAF6-模體2 QEPQEINF
449 HIS標籤 DYKDDDDK
450 TRAF2/TRAF3結合序列源 hTNFR2 PFSKEECAFRS
451 TRAF2/TRAF 3結合序列源 hCD40 AAPVQETLHGC
452 TRAF2/TRAF 3結合序列源 hCD30 MLSVEEEGKED
453 TRAF2/TRAF 3結合序列源 hCD27 TIPIQEDYRKP
454 TRAF2/TRAF 3結合序列源 hLTβR STPHQEDGKAW
455 TRAF2/TRAF 3結合序列源 hATAR TVAVEETIPST
456 TRAF2/TRAF 3結合序列源 hOX40 RTPIQEEQADA
457 TRAF2/TRAF 3結合序列源 m41BB TGAAQEEDACS
458 TRAF2/TRAF 3結合序列源 m41BB RCPQEEEGGGG
459 TRAF2/TRAF 3結合序列源 h41BB VQTTQEEDGCS
460 TRAF2/TRAF 3結合序列源 h41BB RFPEEEEGGCE
461 TRAF2/TRAF 3結合序列源 bLMP1 RTPVQESGYPD
462 TRAF2/TRAF 3結合序列源 bLMP1 RPPVQETGGGG
463 TRAF2/TRAF 3結合序列源 bLMP1 HPPVQETGGGG
464 TRAF2/TRAF 3結合序列源 bLMP1 HPPVQETGEGG
465 TRAF2/TRAF 3結合序列源 bLMP1 HPPIQETGNGG
466 TRAF2/TRAF 3結合序列源 LAT ALSSQEAEEVE
467 TRAF2/TRAF 3結合序列源 hTANK SVPIQCTDKTD
468 TRAF2/TRAF 3結合序列源 hLMP1 PHPQQATDDSS
469 TRAF2/TRAF 3結合序列源 rLMP1 PYPIQATDGGN
470 TRAF2/TRAF 3結合序列源 rLMP1 PHPIQATDGAN
471 TRAF2/TRAF 3結合序列源 rLMP1 PYPVQASDGGD
472 TRAF2/TRAF 3結合序列源 ，次要共有 P/S/A/TXQ/EE
473 TRAF2/TRAF 3結合序列源 ，主要共有 PVQE
474 CD40 TRAF2/TRAF 3變體 CD40 WT KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--PVQE--
475 CD40 TRAF2/TRAF 3變體 CD40/ v41BB TLHGCQPVTQEDGKESRI--SVQE--RQ
476 CD40 TRAF2/TRAF 3變體 CD40/ vTNFR2 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--TQEE--
477 CD40 TRAF2/TRAF 3變體 CD40/ vATAR TLHGCQPVTQEDGKESRISVQERQ
478 CD40 TRAF2/TRAF 3變體 CD40/ vATAR KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--SKEE--
479 CD40 TRAF2/TRAF 3變體 CD40/ v41BB TLHGCQPVTQEDGKESRISVQERQ
480 TRAF6結合序列hCD40 PQEINF
481 TRAF6結合序列hTRANCE-R PQEIDF
482 TRAF6結合序列Mal PPELRF
483 TRAF6結合序列TRIF PEEMSW
484 TRAF6結合序列IRAK (1) PQENSY
485 TRAF6結合序列IRAK (2) PVESDE
486 TRAF6結合序列IRAK (3) PEESDE
487 TRAF6結合序列IRAK-2 (1) PEETDE
488 TRAF6結合序列IRAK-2 (2) PTENGE
489 TRAF6結合序列IRAK-M PVEDDE
490 TRAF6結合序列RIP2 PPENYE
491 TRAF6結合序列MyD88 PSELRF
492 TRAF6共有結合序列 PXEXXAc/Ar
493 CD40 TRAF6變體CD40 WT KKVAKKPTNKAPHPKQE--PQEINF--PDDLPGSNTAAPVQE
494 CD40 TRAF6變體CD40/ vTRIF TLHGCQPVTQEDGKESRISVQERQ
495 CD40 TRAF6變體CD40/ vRIP2 KKVAKKPTNKAPHPKQE--PEEMSW--PDDLPGSNTAAPVQE
496 CD40 TRAF6變體CD40/ vIRAK(1) TLHGCQPVTQEDGKESRISVQERQ
497 CD40 TRAF2/TRAF3/ TRAF6共有變體CD40 WT KKVAKKPTNKAPHPKQE--PQEINF--PDDLPGSNTAA--PVQE--
498 CD40 TRAF2/TRAF3/ TRAF6共有變體 TLHGCQPVTQEDGKESRI--SVQE--RQ
499 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
500 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--(P/S/A/T)X(Q/E)E--TLHGCQPVTQEDGKESRISVQERQ
501 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQE
502 CD40 TRAF2/TRAF3/ TRAF6共有變體 TLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E-RQ
503 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAA--(P/S/A/T)X(Q/E)-ETLHGCQPVTQEDGKESRISVQERQ
504 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAA--(P/S/A/T)X(Q/E)E--TLHGCQPVTQEDGKESRI--(P/S/A/T)X(Q/E)E-RQ
505 CD40 TRAF2/TRAF3/ TRAF6共有變體 KKVAKKPTNKAPHPKQE--PXEXX(Ac/Ar)--PDDLPGSNTAAPVQE
506 CD28(IEV)變體 NKILVKQSPM LVAYDNAVNL SCKYSYNLFS REFRASLHKG LDSAVEVCVV YGNYSQQLQV YSKTGFNCDG KLGNESVTFY LQNLYVNQTD IYFCKIEV
507 SP-TGIT MRWCLLLIWA QGLRQAPLAS G
508 SS1 QVQLQQSGPE LEKPGASVKL SCKASGYSFT GYTMNWVKQS HGKSLEWIGL ITPYNGASSY NQKFRGKATL TVDKSSSTAY MDLLSLTSED SAVYFCARGG YDGRGFDYWG QGTTVTVSSG GGGSGGGGSG GGGSDIELTQ SPAIMSASPG EKVTMTCSAS SSVSYMHWYQ QKSGTSPKRW IYDTSKLASG VPGRFSGSGS GNSYSLTISS VEAEDDATYY CQQWSKHPLT FGAGTKLEIK
509 M5 (人類化SS1) QVQLVQSGAE VEKPGASVKV SCKASGYTFT DYYMHWVRQA PGQGLEWMGW INPNSGGTNY AQKFQGRVTM TRDTSISTAY MELSRLRSDD TAVYYCASGW DFDYWGQGTL VTVSSGGGGS GGGGSGGGGS DIVMTQSPSS LSASVGDRVT ITCRASQSIR YYLSWYQQKP GKAPKLLIYT ASILQNGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCLQ TYTTPDFGPG TKVEIK
510 HN1 QVQLVQSGAE VKRPGASVQV SCRASGYSIN TYYMQWVRQA PGAGLEWMGV INPSGVTSYA QKFQGRVTLT NDTSTNTVYM QLNSLTSADT AVYYCARWAL WGDFGMDVWG KGTLVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSTLSASIG DRVTITCRAS EGIYHWLAWY QQKPGKAPKL LIYKASSLAS GAPRFSGSG SGTDFTLTIS SLQPDDFATY YCQQYSNYPL TFGGGTKLEI K
511 M912 QVQLQESGPG LVKPSETLSL TCTVSGGSVS SGSYYWSWIR QPPGKGLEWI GYIYYSGSTN YNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCARE GKNGAFDIWG QGTMVTVSSG GGGSGGGGSG GGGSDIQMTQ SPSSLSASVG DRVTITCRAS QSISSYLNWY QQKPGKAPKL LIYAASSLQS GVPSGFSGSG SGTDFTLTIS SLQPEDFATY YCQQSYSTPL TFGGGTKVEI K
512 HuYP218 EVQLVESGGG LVQPGGSLRL SCAASGFDLG FYFYACWVRQ APGKGLEWVS CIYTAGSGST YYASWAKGRF TISRDNSKNT LYLQMNSLRA EDTAVYYCAR STANTRSTYY LNLWGQGTLV TVSSGGGGSG GGGSGGGGSD IQMTQSPSSL SASVGDRVTI TCQASQRISS YLSWYQQKPG KVPKLLIYGA STLASGVPSR FSGSGSGTDF TLTISSLQPE DVATYYCQSY AYFDSNNWHA FGGGTKVEI
513 P4 QVQLQQSGPG LVTPSQTLSL TCAISGDSVS SNSATWNWIR QSPSRGLEWL GRTYYRSKWY NDYAVSVKSR MSINPDTSKN QFSLQLNSVT PEDTAVYYCA RGMMTYYYGM DVWGQGTTVT VSSGGGGSGG GGSGGGGSQP VLTQSSSLSA SPGASASLTC TLRSGINVGP YRIYWYQQKP GSPPQYLLNY KSDSDKQQGS GVPSRFSGSK DASANAGVLL ISGLRSEDEA DYYCMIWHSS AAVFGGGTQL TVLS
514 OSM_MFE23 _spCD8_ CD28_CD40 MGVLLTQRTL LSLVLALLFP SMASMQVQLQ QSGAELVRSG TSVKLSCTAS GFNIKDSYMH WLRQGPEQGL EWIGWIDPEN GDTEYAPKFQ GKATFTTDTS SNTAYLQLSS LTSEDTAVYY CNEGTPTGPY YFDYWGQGTT VTVSSGGGGS GGGGSGGGGS ENVLTQSPAI MSASPGEKVT ITCSASSSVS YMHWFQQKPG TSPKLWIYST SNLASGVPAR FSGSGSGTSY SLTISRMEAE DAATYYCQQR SSYPLTFGAG TKLELKRAAA GSGGSGFVPV FLPAKPTTTP APRPPTPAPT IASQPLSLRP EACRPAAGGA VHTRGLDFAC DIYIWAPLAG TCGVLLLSLV ITLYCNHRNR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS KKVAKKPTNK APHPKQEPQE INFPDDLPGS NTAAPVQETL HGCQPVTQED GKESRISVQE RQ
515 人類ICOS_Q9Y6W8   GEINGSANYE MFIFHNGGVQ ILCKYPDIVQ QFKMQLLKGG QILCDLTKTK GSGNTVSIKS LKFCHSQLSN NSVSFFLYNL DHSHANYYFC NLSIFDPPPF KVTLTGGYLH IYESQLCCQL KFWLPIGCAA FVVVCILGCI LICWLTKKKY SSSVHDPNGE YMFMRAVNTA KKSRLTDVTL
516 CD40 TRAF2模體1 PKQE
517 CD40 TRAF2模體2 PVQE
518 CD40 TRAF2模體3 SVQE
519 CD40 TRAF6模體 QEPQEINFP
520 CD40 PKA模體1 KKPTNKA
521 CD40 PKA模體2 SRISVQE
522 CD28 EC ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KP
Ar =芳香族殘基；Ac =酸性殘基；X=任何胺基酸
儘管已詳細闡述了本發明及其優點，但應理解，可在不背離如在隨附申請專利範圍中界定之本發明之精神及範圍的情況下在本文中作出各種改變、替代及更改。
亦考慮下列編號之配置中之各個實施例： 1. 一種嵌合共刺激抗原受體(CoStAR)，其包括： 結合至癌胚抗原(CEA)之細胞外結合結構域或結合至間皮素(MSLN)之細胞外結合結構域，其操作性連接至跨膜結構域，及 第一信號傳導結構域及ICOS之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及NTRK1之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及DAP10之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及CD40信號傳導結構域或其信號傳導片段，或 第一信號傳導結構域及TRAF2/TRAF3序列、TRAF6序列、TRAF2序列或IProx序列中之一或多者。 2. 如配置1之CoStAR，其中該第一信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。 3. 如配置1之CoStAR，其中該CoStAR包括第二信號傳導結構域。 4. 如配置3之CoStAR，其中該第二信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。 5. 如配置1之CoStAR，其中該CD40信號傳導片段包括SH3模體(KPTNKAPH, SEQ ID NO:35)、TRAF2模體(PKQE, SEQ ID NO:36, PVQE, SEQ ID NO:37, SVQE, SEQ ID NO:38)、TRAF6模體(QEPQEINFP, SEQ ID NO:39)、PKA模體(KKPTNKA, SEQ ID NO:40, SRISVQE, SEQ ID NO:41)或其組合，或係全長CD40細胞內結構域。 6. 如配置2之CoStAR，其中該第一信號傳導結構域包括全長共刺激結構域。 7. 如配置1之CoStAR，其中該細胞外結合結構域藉由連接體及/或間隔體操作性連接至該跨膜結構域。 8. 如配置7之CoStAR，其中該連接體包括約5至約20個胺基酸。 9. 如配置7之CoStAR，其中該連接體或間隔體包括約10至約250個胺基酸。 10.   如配置1之CoStAR，其中該CoStAR包括第二細胞外結合結構域。 11.   如配置10之CoStAR，其中該第二細胞外結合結構域包括來自CD8、CD28或ICOS之配體結合結構域。 12.   如配置1之CoStAR，其中該跨膜結構域包括來自CD28、CD8、ICOS、DAP10或NTRK之跨膜結構域。 13.   如配置1之CoStAR，其中該跨膜結構域包括SEQ ID NO:20、SEQ ID NO:21或SEQ ID NO:22之跨膜結構域序列。 14.   如配置1之CoStAR，其中該細胞外結合結構域包括scFv、肽、抗體重鏈可變結構域、抗體輕鏈可變結構域或CEA配體或MSLN配體。 15.   如配置1至14中任一項之CoStAR，其進一步在C末端處包括CD3ζ信號傳導結構域。 16.   如配置1至14中任一項之CoStAR，其進一步包括N末端信號肽。 17.   如配置16之CoStAR，其中該N末端信號肽包括抑瘤素M (OSM)、CD8α、CD2、介白素-2 (IL-2)、顆粒球-巨噬球群落刺激因子(GM-CSF)或人類IgGκ之信號肽。 18.   一種核酸，其編碼如配置1至17中任一項之CoStAR。 19.   一種載體，其包括如配置18之核酸。 20.   一種細胞，其表現如配置1至16中任一項之CoStAR。 21.   如配置20之細胞，其中該細胞包括α-β T細胞、γ-δ T細胞、T調控細胞、TIL、NKT細胞或NK細胞。 22.   如配置20之細胞，其中該細胞共表現CAR或TCR。 23.   一種製備如配置20之細胞之方法，其包括使用如配置19之載體轉導或轉染細胞之步驟。 24.   一種製備表現如配置1至16中任一項之CoStAR之細胞群體之方法，其包括 i)檢測該CoStAR在經如配置19之載體轉染或轉導之細胞之表面上的表現；及 ii)選擇鑑別為表現該CoStAR之細胞。 25.   一種細胞群體，其富集如配置1至16中任一項之CoStAR之細胞表現。 26.   一種治療個體之疾病之方法，其包括向該個體投與如配置20至22中任一項之細胞或如配置25之細胞群體之步驟。
在一些實施例中，可藉由與表現CoStAR scFv之靶抗原之細胞一起共培育來評估CoStAR功能。在一些實施例中，用於評估CoStAR功能之細胞係Ovcar3細胞。在一些實施例中，用於評估CoStAR功能之細胞係Ovcar-OKT-3細胞。在一些實施例中，Ovcar3細胞上所表現之MSLN向CoStAR表現細胞提供信號2。在一些實施例中，Ovcar3細胞上所表現之OKT-3向CoStAR表現細胞提供信號1。在一些實施例中，信號1及信號2皆提供至來自Ovcar-OKT3細胞之CoStAR表現細胞。在一些實施例中，靶細胞係K562細胞。在一些實施例中，K562細胞上所表現之OKT-3向CoStAR表現細胞提供信號1。在一些實施例中，信號1及信號2皆提供至來自K562-OKT3-CEACAM5細胞之CoStAR表現細胞。
在一些實施例中，CoStAR轉導細胞所展現之倍數擴增高於暴露於信號1及信號2之未轉導T細胞。在一些實施例中，在使用靶細胞連續再刺激之後，CoStAR轉導細胞繼續展現增強之擴增。在一些實施例中，此增強之擴增可在使用CoStAR構築體轉導後刺激1週、2週、3週、4週、5週或6週。在一些實施例中，靶細胞係K562-OKT3-CEACAM5細胞。
在一些實施例中，在轉導之後數天檢測到高含量之 CoStAR表現陽性細胞。在一些實施例中，在以下時間時檢測到高含量之CoStAR表現陽性細胞：在轉導之後1天、在轉導之後2天、在轉導之後3天、在轉導之後4天、在轉導之後5天、在轉導之後6天、在轉導之後1週、在轉導之後2週、在轉導之後3週或在轉導之後4週。在一些實施例中，CoStAR表現陽性細胞之百分比為20%、25%、30%、35%、40%、45%、50%、55%、60%、65%、70%、75%、80%、85%、95%或大於95%。
亦考慮下列編號之配置中之各個實施例： 1.     一種嵌合共刺激抗原受體(CoStAR)，其包括： 結合至癌胚抗原(CEA)之細胞外結合結構域或結合至間皮素(MSLN)之細胞外結合結構域，其操作性連接至跨膜結構域，及 第一信號傳導結構域及ICOS之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及NTRK1之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及DAP10之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及CD40信號傳導結構域或其信號傳導片段，或 第一信號傳導結構域及TRAF2/TRAF3序列、TRAF6序列、TRAF2序列或IProx序列中之一或多者。 2.     如配置1之CoStAR，其中該第一信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。 3.     如配置1之CoStAR，其中該CoStAR包括第二信號傳導結構域。 4.     如配置3之CoStAR，其中該第二信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。 5.     如配置1之CoStAR，其中該CD40信號傳導片段包括SH3模體(KPTNKAPH, SEQ ID NO:35)、TRAF2模體(PKQE, SEQ ID NO:36, PVQE, SEQ ID NO:37, SVQE, SEQ ID NO:38)、TRAF6模體(QEPQEINFP, SEQ ID NO:39)、PKA模體(KKPTNKA, SEQ ID NO:40, SRISVQE, SEQ ID NO:41)或其組合，或係全長CD40細胞內結構域。 6.     如配置2之CoStAR，其中該第一信號傳導結構域包括全長共刺激結構域。 7.     如配置1之CoStAR，其中該細胞外結合結構域藉由連接體及/或間隔體操作性連接至該跨膜結構域。 8.     如配置7之CoStAR，其中該連接體包括約5至約20個胺基酸。 9.     如配置7之CoStAR，其中該連接體或間隔體包括約10至約250個胺基酸。 10.   如配置1之CoStAR，其中該CoStAR包括第二細胞外結合結構域。 11.   如配置10之CoStAR，其中該第二細胞外結合結構域包括來自CD8、CD28或ICOS之配體結合結構域。 12.   如配置1之CoStAR，其中該跨膜結構域包括來自CD28、CD8、ICOS、DAP10或NTRK之跨膜結構域。 13.   如配置1之CoStAR，其中該跨膜結構域包括SEQ ID NO:20、SEQ ID NO:21或SEQ ID NO:22之跨膜結構域序列。 14.   如配置1之CoStAR，其中該細胞外結合結構域包括scFv、肽、抗體重鏈可變結構域、抗體輕鏈可變結構域或CEA配體或MSLN配體。 15.   如配置1至14中任一項之CoStAR，其進一步在C末端處包括信號傳導結構域。 16.   如配置1至14中任一項之CoStAR，其進一步包括N末端信號肽。 17.   如配置16之CoStAR，其中該N末端信號肽包括抑瘤素M (OSM)、CD8α、CD2、介白素-2 (IL-2)、顆粒球-巨噬球群落刺激因子(GM-CSF)或人類IgGκ之信號肽。 18.   一種核酸，其編碼如配置1至17中任一項之CoStAR。 19.   一種載體，其包括如配置18之核酸。 20.   一種細胞，其表現如配置1至16中任一項之CoStAR。 21.   如配置20之細胞，其中該細胞包括α-β T細胞、γ-δ T細胞、T調控細胞、TIL、NKT細胞或NK細胞。 22.   如配置20之細胞，其中該細胞共表現CAR或TCR。 23.   一種製備如配置20之細胞之方法，其包括使用如配置19之載體轉導或轉染細胞之步驟。 24.   一種製備表現如配置1至16中任一項之CoStAR之細胞群體之方法，其包括 i)檢測該CoStAR在經如配置19之載體轉染或轉導之細胞之表面上的表現；及 ii)選擇鑑別為表現該CoStAR之細胞。 25.   一種細胞群體，其富集如配置1至16中任一項之CoStAR之細胞表現。 26.   一種治療個體之疾病之方法，其包括向該個體投與如配置20至22中任一項之細胞或如配置25之細胞群體之步驟。 27.   一種融合蛋白，其中該融合蛋白包括： 對CEA具有特異性之結合結構域，其連接至下一結構； 跨膜結構域，其連接至下一結構； ICOS結構域，其連接至下一結構； CD40信號傳導結構域。 28.   一種融合蛋白，其中該融合蛋白包括： 對MSLN具有特異性之結合結構域，其連接至下一結構； 跨膜結構域，其連接至下一結構； CD28結構域，其連接至下一結構； CD40信號傳導結構域。 29.   一種融合蛋白，其中該融合蛋白包括： 第一序列，其與SEQ ID NO: 12至少70%一致； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 518至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。 30.   一種融合蛋白，其中該融合蛋白包括： 第一序列，其與SEQ ID NO: 186-191中之任一者至少70%一致； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 25至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。 31.   一種融合蛋白，其中該融合蛋白包括： HCDR1，其係SEQ ID NO: 12中之HCDR1； HCDR2，其係SEQ ID NO: 12中之HCDR2； HCDR3，其係SEQ ID NO: 12中之HCDR3； LCDR1，其係SEQ ID NO: 12中之LCDR1； LCDR2，其係SEQ ID NO: 12中之LCDR2； LCDR3，其係SEQ ID NO: 12中之HCDR3， 其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 515至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。 32.   如配置31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。 33.   如配置31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。 34.   如配置31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 515至少70%一致之ICOS序列。 35.   如配置31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。 36.   一種融合蛋白，其中該融合蛋白包括： HCDR1，其係SEQ ID NO: 186-191中之HCDR1； HCDR2，其係SEQ ID NO: 186-191中之HCDR2； HCDR3，其係SEQ ID NO: 186-191中之HCDR3； LCDR1，其係SEQ ID NO: 186-191中之LCDR1； LCDR2，其係SEQ ID NO: 186-191中之LCDR2； LCDR3，其係SEQ ID NO: 186-191中之HCDR3 其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 25至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。 37.   如配置36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。 38.   如配置36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。 39.   如配置36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 19至少70%一致之CD28 TM序列。 40.   如配置36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 25至少70%一致之CD28序列。 41.   如配置36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。 42.   一種細胞治療方法，其包括： a)鑑別個體，其中該個體患有表現MSLN或CEA之癌症；及 b)投與如前述配置中任一項之CoSTaR或融合蛋白中之任一者或多者。 43.   一種治療個體之表現MSLN或CEA之癌症之方法，該方法包括： a)鑑別個體，其中該個體患有表現MSLN或CEA之癌症；及 b)投與如前述配置中任一項之CoSTaR或融合蛋白中之任一者或多者。
本發明進一步闡釋於下列實例中，該等實例僅出於闡釋目的而給出且並不意欲以任何方式限制本發明。 實例 實例1 -表現CoStAR之T細胞之產生 材料及方法
構築體設計- MFE23 CoStAR由具有抑瘤素M1前導序列且融合至整個人類CD28核酸序列之MFE23源單鏈抗體片段核苷酸序列組成。藉由Genewiz Inc對CoStAR核苷酸序列進行密碼子最佳化及基因合成。經由XbaI及NheI位點將構築體選殖至pSF.Lenti (Oxford Genetics)中。
構築體設計- MFE23 CoStAR由具有抑瘤素M1、CD8α、CD2、IL-2、GM-CSF或hIgGκ VIII前導序列之CEA特異性MFE23、人類化(hu) MFE23、CEA6、BW431/26或huT84.66源單鏈抗體片段核苷酸序列組成。每一CoStAR具有衍生自CD8或CD28或截短CD28之細胞外間隔體結構域及衍生自CD28及CD40之信號傳導結構域。將構築體選殖至含有MND啟動子之pSF.Lenti (Oxford Genetics)中，並經由P2A裂解序列與截短CD34標記基因分隔。
慢病毒產生-使用三質體包裝系統(Cell Biolabs, San Diego, USA)藉由將10 μg每一質體加上10 μg含有轉基因之pSF.Lenti慢病毒質體在含有50 mM CaCl 2之無血清RPMI中一起混合來實施慢病毒產生。將混合物逐滴添加至75 cm 2燒瓶中之50%鋪滿之293T細胞單層中。在轉染後48及72h時收集病毒上清液，彙集並使用LentiPac慢病毒上清液濃縮液(GeneCopoeia, Rockville, Maryland, USA)根據製造商說明書來進行濃縮。將慢病毒上清液濃縮10倍並直接用於在4 μg/ml聚凝胺(Sigma-Aldrich, Dorset, UK)存在下感染原代人類T細胞。自正常健康供體分離周邊血單核細胞，然後使用T細胞活化及擴增珠粒(Invitrogen)根據製造商說明書來活化24小時，隨後添加慢病毒上清液。
在感染後96小時使用CEA.hFc蛋白及二級抗hFc-PE +抗CD34-APC或僅藉由抗CD34-PE抗體來評價細胞轉導。然後使用x10供體失配之經輻照PBMC飼養細胞以1:20- 1:200比率於RPMI + 10% FCS中在添加1 μg/ml PHA及200 IU/ml IL-2下來進一步擴增細胞。在14天之後，如先前所述將細胞染色並儲存以備用於分析。
藉由混合CoStAR陽性或陰性細胞與野生型或經OKT3改造之CEA陽性LoVo或LS174T細胞來實施功能性分析。簡言之，在96孔板中以不同比率混合T細胞與LoVo細胞並藉由ELISA量測IFNγ或IL-2。將剩餘細胞與WST-1試劑(Sigma, UK)之1:10稀釋液一起培育30 min，然後在450nm下讀取吸光度。使用下列方程式= 100 - ((實驗讀數-僅T細胞之讀數) / (僅腫瘤之讀數)) ×100來測定細胞毒性%。
藉由以下方式來實施增殖分析：首先在37℃下以1×10 7個細胞/ml之濃度向T細胞中加載10 μM eFluor450增殖染料(eBioscience, UK) 10 min，然後將細胞在冰上於5體積冷T細胞培養基中培育5 min。然後深度洗滌細胞以去除未結合染料並添加至含有腫瘤細胞之共培養物中。在第2、6及10天取出細胞，添加DRAQ7之1:200稀釋液並使用MACSQuant細胞計數器及MACSQuantify軟體分析細胞。
藉由以下方式實施增殖分析以獲得細胞計數：自孔獲取細胞並使用抗CD2 PerCP eFluor710抗體(eBioscience, UK)於暗處染色20 min，隨後實施DRAQ7染色並使用MACSQuant分析儀進行計數。 結果
自獲自NHSBT之膚色血球層來分離原代人類T細胞。藉由Ficoll介導之分離及T細胞陰性分離套組(StemCell Technologies)來分離T細胞。使用人類T細胞活化及擴增珠粒(Invitrogen, UK)活化經分離T細胞。將細胞與經濃縮慢病毒顆粒一起培育並擴增數天。慢病毒含有MFE.CoStAR.2A.tCD34構築體(融合至經由2A裂解序列與截短人類CD34共表現之全長人類CD28之MFE23.scFv)之DNA序列。使用經輻照飼養細胞如材料及方法中所概述來進一步擴增成功轉導之細胞。經量測供體1轉導為22.69% (17.15 CD34+/CoStAR+加上5.53% CD34-/CoStAR+)，經量測供體2為20.73%，且供體3為13.34%。使用抗CD34抗體使細胞富集CoStAR表現以獲得大於90% CoStAR陽性之T細胞群體。
為生成生理相關之活體外模型以測試CoStAR對T細胞活性之影響，針對CEA+腫瘤細胞系LoVo及LS174T來測試未轉導及經轉導之細胞。為使得能夠因應於不匹配腫瘤細胞系來活化T細胞，改造腫瘤細胞以表現藉助合成跨膜結構域錨定至細胞膜且使用IRES元件與GFP標記基因分隔之抗CD3單鏈抗體片段，從而使用流式細胞術來觀察轉導細胞。
自大量轉染子生成LoVo及LS174T之單細胞純系。以不同效應物:靶比率混合未轉導及經CoStAR轉導之T細胞與野生型未轉導或經OKT3改造之LS174T或LoVo細胞。在24小時之後，獲取共培養基以供IL-2 ELISA量測。因應於經OKT3改造之LS174T細胞自來自三個供體之CoStAR+及CoStAR- T細胞群體皆觀察到活化依賴性IL-2分泌，且因應於未改造腫瘤細胞自經轉導及未轉導之T細胞僅看到背景IL-2分泌(圖3 A-C)。在所測試之所有三個供體中皆發現針對經OKT3改造之腫瘤細胞之CoStAR增強的IL-2分泌。該效應在E:T比率為8:1及16:1時最為明顯，且在更高E:T比率下IL-2分泌過低以致不能準確量測。在較低效應物對靶比率下，來自未轉導細胞之IL-2分泌似乎飽和。該等觀察重現於LoVo細胞中，且針對LS174T測試之三個供體中之兩者具有類似結果(圖3D & E)。
為測定CoStAR對T細胞擴增之影響，混合經轉導或未轉導之T細胞與野生型或經OKT3-GFP改造之LoVo細胞，對3天後之總細胞數進行計數。在存在IL-2 (圖4A)及不存在IL-2 (圖4B)下，因應於LoVo-OKT3 CoStAR增強了經改造T細胞之存活及/或增殖，但針對野生型LoVo細胞並無增強。為進一步研究此現象，在來自兩個供體之T細胞中使用增殖染料來實施細胞增殖分析以對每一群體在6天內所經歷之細胞週期數進行計數(圖4C & D)。因應於LoVo- OKT3，較大比例之CoStAR改造細胞與未改造細胞相比在6天內經歷5、6或7個增殖週期；而因應於野生型LoVo，經CoStAR轉導及未轉導之細胞在相同持續時間內經歷平均大約2個週期。
生成由融合至N末端其他共刺激結構域之CD28組成之各種融合受體。選擇自CD137、CD2、CD29、CD134、CD150、CD40、GITR獲得之共刺激結構域及來自IL-2受體γ-鏈(IL2Rγ)之信號傳導結構域。包含接近於先前可誘導共刺激研究中所使用者之受體。稱為CD28(IEV)之此受體係截短的，從而CD28之C末端模體係胺基酸三聯體「IEV」。藉由Genewiz重新生成序列並在EF1α啟動子下與藉由2A自裂解肽與融合CoStAR分隔之CD34標記基因一起選殖至慢病毒載體中。使用EasySep珠粒(StemCell Technologies)分離原代CD8+ T細胞並使用抗CD3/抗CD28活化/擴增Dynabeads活化，然後添加慢病毒顆粒。在短擴增期後，混合細胞與LoVo或LoVo-OKT3細胞，並納入抗CD107a抗體以及佈雷菲德菌素(brefeldin)及莫能菌素(monensin)，且在16小時培育後，將其固定並標記基因(CD34)之抗體以及IL-2、IFNγ及bcl-xL之抗體進行染色。使用MACSQuant分析儀及MACSQuantify軟體來實施分析。圖5展示CD34- (未經CoStAR轉導)及CD34+ (經CoStAR轉導)之IL-2反應。統計學分析證實，所測試之所有受體皆誘導在含有變異CoStAR受體時產生IL-2之細胞之比例顯著增加。同時量測以下三種其他讀出：IFNγ，在正常信號1條件下釋放但藉由共刺激增強之細胞介素；CD107a，去顆粒標記物；及bcl-xL，藉由共刺激上調之抗細胞凋亡蛋白。CoStAR之銜接不同程度地增強了所分析之所有效應功能。CD28.CD2及CD28.CD40融合體受體似乎誘發了所測試之所有受體中之最穩定反應(參見圖6) 實例2
比較基於CD28及CD28.CD40之CoStAR對基於群體之細胞介素分泌之效應。使用CD28(IEV)截短CoStAR、全長CD28 CoStAR或CD28.CD40 CoStAR (具有如SEQ ID NO:439中所展示之全長CD28，但缺乏N末端N及K殘基)轉導來自三個供體之原代T細胞，或保持未轉導。使用CD34標記基因使T細胞富集CoStAR表現，且在擴增後混合該等細胞與LoVo-OKT3細胞，並藉由ELISA分析IL-2分泌(參見圖7)。未轉導細胞平均產生0.80 ng/ml IL-2，且CD28(IEV)及全長CD28 CoStAR分別產生4.6 ng/ml及5.0 ng/ml IL-2。然而，在三個供體中，CD28.CD40平均誘導29.0 ng/ml IL-2，由此證實了將CD40納入基於CD28之基本CoStAR中之顯著益處。
接下來，分析CoStAR對T細胞擴增之效應。使用具有抗CA125 (196-14)或抗葉酸鹽受體(MOV-19) scFv或抗葉酸鹽受體肽(C7)抗原結合結構域之CD28或CD28.CD40 CoStAR轉導來自7個供體之T細胞。使用具有抗CEA scFv之CD28 CoStAR轉導其他細胞以作為失配對照。然後將細胞與經改造以表現膜結合OKT3之CA125+/葉酸鹽受體+/CEA-細胞系OvCAR3 (OvCAR-OKT3)混合。在7、14及21天之後進行T細胞計數，且在第7及14天添加新鮮OvCAR- OKT3。觀察到含有抗CA125 scFv之細胞之有限擴增(平均倍數擴增：CD28: 15.1；CD28.CD40: 69.1)，然而，在CD28及CD28.CD40小組中，使用scFv靶向葉酸鹽受體之細胞發生擴增(平均倍數擴增：CD28: 186.7；CD28.CD40: 1295.0)。在使用C7肽靶向葉酸鹽受體時，可看到更有限擴增(平均倍數擴增：CD28: 71.5；CD28.CD40: 28.0)。對照CEA靶向受體顯示有限擴增(平均倍數擴增：28.0)。
為更佳地理解信號1及信號2之協同作用，使用在HLA-A*02背景中識別CEA肽(691-699)之鼠類恆定結構域修飾TCR以及靶向細胞表面CEA蛋白之CD28或CD28.CD40 CoStAR來改造T細胞。作為對照，亦使用CA125特異性CD28 CoStAR轉導細胞。混合T細胞與HLA-A*02+/CEA+ H508細胞並藉由細胞內流式細胞術染色來分析細胞介素產生。使用針對鼠類TCRβ恆定結構域(標記TCR改造細胞)以及DYKDDDDK (SEQ ID NO:449)表位標籤(標記CoStAR改造細胞)之抗體來實施流式細胞術圈選。因此，可分析每一共培養孔中之TCR-/CoStAR-、TCR+/CoStAR-、TCR-/CoStAR+及TCR+/CoStAR+細胞。然後對CD4+或CD8+ T細胞之每一亞群體中之細胞介素產生進行繪圖(圖9)。在CD4+細胞中，CD28.CD40 CoStAR較單獨TCR刺激增強了CD137及TNFα產生，然而，CD4+細胞中之TCR反應較差，此乃因TCR對CD8具有依賴性。在CD8+細胞中，IL-2及CD107a之效應活性尤其更為穩定，從而展示了CD28.CD40 CoStAR組中之較強誘導。為更佳地比較各受體，對CD4+及CD8+細胞中僅TCR+/CoStAR+組中之效應活性進行繪圖(圖10)。在CD4+細胞中，與靶向CEA或失配靶向之CD28 CoStAR相比，CD137誘導由CD28.CD40顯著增強。在CD8+細胞中，CD137誘導顯著高於靶向CEA或失配靶向之CD28 CoStAR中者，而CD107a誘導高於對照CoStAR中者。因此，在各種模型及效應活性中，CD28.CD40展示增強之效應活性。 實例3
為評估具有CD40之CoStAR之共刺激，模擬轉導原代人類T細胞或使用MFE23.CD28或MFE23.CD28.CD40 CoStAR (各自具有由2A裂解肽分隔之CD34標記基因)進行轉導。MFE23係對癌胚抗原(CEA)具有高親和力之單鏈Fv抗體。在活體外培養後，使用MACS™順磁性選擇試劑(Miltenyi Biotech)針對CD34來富集細胞且然後使用經輻照飼養細胞擴增細胞數。MFE23.CD28 CoStAR強烈介導CD34 +T細胞之擴增，且MFE23.CD28.CD40 CoStAR進一步增強擴增(圖11)。
為評估共刺激活性及持久性，將經模擬轉導或經MFE23.CD28或MFE23.CD28.CD40轉染之T細胞與LoVo-OKT3細胞以8:1效應物:靶比率在存在(200 IU/ml)或不存在外源性IL-2下一起共培養。在第1、4、7、11及18天，獲取細胞並藉由使用抗CD2試劑在MACSQuant流式細胞儀上來計算活T細胞之數量。在不存在腫瘤刺激及IL-2下，細胞數發生預期下降(圖12A)。在不存在刺激但存在IL-2下，細胞具有較明顯存活，但並無特異性生長(圖12B)。在存在腫瘤但不存在IL-2下，模擬細胞不展示特異性存活。MFE23.CD28 CoStAR在前4天中介導明顯之擴增倍增，隨後有所下降。MFE23.CD28.CD40介導較大擴增至第7天，隨後平穩下降(圖12C)。在相同條件下但在存在IL-2下，模擬及MFE23.CD28轉導細胞皆在18天內顯示20倍擴增，而MFE23.CD28.CD40細胞擴增60倍以上(圖12D)。因此，在刺激條件下於存在及不存在外源性IL-2下，基於CD28.CD40之受體皆顯示優良之擴增及存活。
然後測試經模擬轉導及經MFE23.CD28或MFE23.CD28.CD40 CoStAR轉導之T細胞之細胞介素產生。對自T細胞/腫瘤共培養獲得之上清液實施珠粒陣列分析。將經改造T細胞與LoVo-OKT3細胞以1:1效應物:靶比率一起培育24小時並收集上清液。亦自相等數量之單獨T細胞或單獨LoVo-OKT3細胞收集條件化上清液。使用Legendplex™人類TH1/TH2細胞介素面板(Biolegend)分析IL-2、IFN-γ、TNFα、IL-4、IL-5、IL-13、IL‑17A、IL-17F、IL-22、IL-6、IL-10、IL-9及IL-21之產生(圖13A-13M)。在來自僅T細胞或腫瘤之培養基中，細胞介素極低或不可檢測。然而，在與腫瘤一起共培養時，細胞介素產生有所增強。與模擬相比，MFE23.CD28增強了IL-2、IL-5、IL-17A/17F、IL-10、IL-9及IL-21之產生。然而，MFE23.CD28.CD40亦增強了TNFα、IL-13及IL-22之產生。MFE23.CD28.CD40亦使諸多細胞介素之產生增強至大於由MFE23.CD28誘發者(IL-2、IL-9及IL-17F)，且亦將一些細胞介素之產生降至低於使用MFE23.CD28所見之程度(IL-5及IL-10)。總而言之，此數據表明，將CD40添加至基於CD28之共刺激受體中增強及/或調節了其關於趨化介素產生之比活性。
進一步測試經模擬轉導及經MFE23.CD28或MFE23.CD28.CD40 CoStAR轉導之T細胞之趨化介素產生。使用Legendplex™人類促發炎性趨化介素面板分析IL-8 (CXCL8)、IP-10 (CSCL10)、嗜酸性粒細胞趨化因子(CCL11)、TARC (CCL17)、MCP-1 (CCL2)、RANTES (CCL5)、MIP-1a (CCL3)、MIG (CXCL9)、ENA-78 (CXCL5)、MIP-3α (CCL20)、GROα (CXCL1)、I-TAC (CXCL11)及MEP-1β (CCL4)之產生。(圖14A-14M)。在來自僅T細胞之培養基中，趨化介素極低或不可檢測。然而，在與腫瘤一起共培養時，趨化介素產生有所增強。與模擬相比，MFE23.CD28增強了CXCL5、CXCL10、CXCL11、CCL17及CCL20之產生。然而，MFE23.CD28.CD40亦增強了CCL2、CXCL1及CXCL9之產生。MFE23.CD28.CD40亦進一步將某些細胞介素之產生增強至大於由MFE23.CD28誘發者之量(CXCL1、CXCL9、CXCL10、CXCL11、CCL17、CCL2、CXCL9、CCL5及CCL20)而將一些細胞介素之產生降至低於使用MFE23.CD28可見之程度(CCL4)。總而言之，此數據表明，將CD40添加至基於CD28之共刺激受體中增強及/或調節了其關於趨化介素產生之比活性。
測試CoStAR針對癌症靶之功能活性。使用經對FolR或CA125具有特異性之scFv結合結構域(分別係scFv MOV19及scFv 196-14)改造之CD28或CD28.CD40 CoStAR來轉導細胞。人類葉酸鹽受體α (FolR)代表諸多腫瘤(包含卵巢、頭頸、腎及肺腫瘤)之適宜靶且CA125代表卵巢癌之替代靶。使用196-14.CD28、196-14.CD28.CD40、MOV19.CD28或MOV19.CD28.CD40受體(皆含有用於檢測之DYKDDDDK表位標籤)改造來自6個健康供體之原代人類T細胞。混合轉導細胞與FolR+/CA125+ OvCAR-OKT3細胞，然後使用細胞內染色分析表位標籤陽性及陰性群體中之效應活性。與經模擬轉導之細胞相比，在因應於CA125及FolR之CD28及CD28.CD40改造細胞中觀察到效應活性(如根據IL-2 (圖15A及15B)、TNFα (圖15C及15D)、CD137 (圖15E及15F)及BCL-xL (圖15G及15H)之產生所測定)之特異性增強，但與MOV19.CD28.CD40相比MOV19.CD28之特異性BCL-xL誘導並不顯著。
評估經模擬轉導之TIL或經MOV19.CD28.CD40 CoStAR改造之TIL中由患者匹配之腫瘤消解物刺激之擴增及CD137產生(圖16)。測試三個供體腫瘤，其在消解時顯示自陰性(6A)、低表現(6B)至高表現(6C)之不同含量之FolR。與FolR陰性消解物匹配之CoStAR改造TIL群體中之模擬及CoStAR陰性TIL在腫瘤共培養後顯示類似程度之CD137上調，此並不因存在CoStAR而增強(圖16D)。在暴露於FolR低表現消解物之TIL中，與CoStAR-細胞相比CoStAR+細胞中之活性有所增強，其中CD137表現自＜10%增至＞20% (圖16E)。在暴露於FolR高表現性腫瘤消解物之TIL中，CoStAR-群體中之活性增加約20%，在CoStAR+群體中最高增加大約50% (圖16F)。
檢驗靶向FolR之CoStAR對效應功能之增強。因應於FolR+腫瘤消解物，MOV19.CD28.CD40將CD137表現自約20%增強至約50% (圖17A)，將TNFα產生自10%增強至15% (圖17B)且將IL2產生自2%增強至5% (圖17C)。
亦檢驗可溶性配體之CoStAR介導之刺激。使用MOV19.CD28或MOV19.CD28.CD40 CoStAR改造來自三個健康供體之T細胞，並使用固定OKT3 (在不存在FolR下提供刺激)或使用OvCAR-OKT3活化以提供TCR及CoStAR活性。在OKT3刺激後，三個供體中之Bcl-XL活性自10%增至20% (圖18A)，而IL2自0%增至12% (圖18B)且TNFα自0%增至20% (圖18C)。外源性可溶性FolR之存在並不增強該等特定效應功能中之任一者。在OvCAR-OKT3存在下，CD28 CoStAR之Bcl-XL誘導增強約20%且CD28.CD40 CoStAR之BCL-XL誘導增強約35% (圖18D)，CD28 CoStAR之IL-2誘導增強約20%且CD28.CD40 CoStAR之IL-2誘導增強30-50% (圖18E)，並且CD28 CoStAR之TNFα產生增強20-30%且CD28.CD40 CoStAR之TNFα產生增強25-50% (圖18F)。外源性可溶性FolR對該等效應功能中之任一者不具有抑制效應。 實例4 材料及方法
構築體設計- MFE23、MOV19及196-14 CoStAR構築體包含具有抑瘤素M1前導序列且融合至共刺激結構域之MFE23 (CEA特異性)、MOV19 (葉酸鹽受體α特異性)或196-14 (CA125特異性)源單鏈抗體片段核苷酸序列。共刺激結構域含有衍生自人類CD8或CD28之細胞外間隔體區及跨膜結構域以及CD28、CD2或CD137及/或野生型或突變CD40變體之信號傳導結構域。本文所詳述之一些CoStAR包括融合至CD28及CD40之人類PD1細胞外結構域。使用P2A裂解序列及截短形式之人類CD34選殖受體以允許檢測轉導細胞。藉由Genewiz Inc對CoStAR核苷酸序列進行密碼子最佳化及基因合成。將構築體選殖至第三代慢病毒載體中。
自正常健康供體分離周邊血單核細胞，然後使用T細胞活化及擴增珠粒(Invitrogen)根據製造商說明書來活化24小時，隨後添加慢病毒上清液。
在感染後96小時使用CEA.hFc蛋白(R&D Systems)及二級抗hFc-PE +抗CD34-APC或僅藉由抗CD34-PE抗體來評價細胞轉導。然後使用x10供體失配之經輻照PBMC飼養細胞以1:20- 1:200比率於RPMI + 10% FCS中在添加30 ng/ml OKT3及200 IU/ml IL-2下來進一步擴增細胞。在14天之後，如先前所述將細胞染色並儲存以備用於分析。
藉由混合CoStAR陽性或陰性細胞與野生型或經OKT3改造之CEA陽性LoVo細胞來實施功能性分析。簡言之，以不同比率在96孔板中混合T細胞與LoVo細胞。對於流動分析而言，將共培養物與佈雷菲德菌素及莫能菌素以及抗CD107a抗體一起培育16小時，隨後使用固定活性染料ef450 (eBiosciences)將細胞染色，使用4%低聚甲醛固定且然後使用Fix/Perm洗滌緩衝液(BD Biosciences)滲透。然後使用抗CD34或抗DYKDDDDK抗體將細胞染色以區分CoStAR+及CoStAR-群體、抗IL-2、抗TNFα及抗IFNγ抗體(Biolegend)。對於可溶性分析物分析而言，收集上清液以藉由ELISA、細胞介素珠粒陣列(LEGENDPLEX™人類Th細胞介素面板(12重))或趨化介素珠粒陣列(LEGENDPLEX™人類促發炎性趨化介素面板(13重)進行分析。
藉由以8:1效應物:靶比率於完整T細胞培養基(TCM：補充有10% FCS、0.01 M HEPES及1%青黴素(Penicillin)/鏈黴素(streptomycin)、50 mM β-巰基乙醇之RPMI)在存在或不存在IL-2下混合T細胞及腫瘤細胞來實施增殖分析。在指示時間點下進行細胞計數且在再刺激分析中以8:1之最終E:T添加新鮮腫瘤細胞。藉由以下方式實施增殖分析以獲得細胞計數：自孔獲取細胞並使用抗CD2 PerCP eFluor710抗體(eBioscience, UK)於暗處染色20 min，隨後實施DRAQ7染色並使用MACSQuant分析儀進行計數。 實例5 CEA實例5
PD1融合受體：使用指示PD1融合CoStAR受體或MFE23.CD28.CD40 CoStAR (陽性對照)或196-14.CD28.CD40 (陰性對照)轉導自三個單獨健康供體分離之原代人類T細胞。基於詳述於Ankri等人，J Immunol 2013; 191:4121-4129及Prosser等人，Molecular Immunology 51 (2012) 263- 272中之形式來選擇PD1融合受體，但向信號傳導結構域中添加CD40。在一些實驗中，細胞在Dynabead去除後方用於基於流式細胞術之分析中。為此，將經轉導T細胞與LoVo-OKT3 (PDL1+, CEA+, CA125-)在尼沃魯單抗(Nivolumab) (抗PD1)或同型匹配(IgG4)之對照抗體存在下或在不添加抗體下一起共培養，且然後藉由流式細胞術評價CD34+ (CoStAR+)及CD34- (CoStAR-)細胞中之效應功能活性(CD137、IFNγ、TNFα及IL-2)。與未轉導細胞或PD1.CD28.CD40受體陰性細胞相比，PD1.CD28.CD40融合受體陽性細胞因應於LoVo-OKT3細胞誘發增強之效應功能活性。此效應亦觀察於在存在IgG4同型對照下培育之孔中，但在尼沃魯單抗處理孔中未觀察到。使用MFE23.CD28.CD40 (而非196-15.CD28.CD40)轉導之對照細胞亦因應於LoVo-OKT3顯示增強之效應活性。
經由CD34細胞表面標記物富集轉導細胞並與LoVo-OKT3細胞一起培育過夜，然後經由ELISA以及細胞介素及趨化介素珠粒陣列分析細胞培養上清液。與未轉導細胞LoVo-OKT3細胞相比，經PD1.CD28.CD40融合受體改造之細胞產生更多之IL-2及CXCL10。此效應亦觀察於在存在IgG4同型對照抗體下，但在尼沃魯單抗(抗PD1)存在下未觀察到。使用MFE23.CD28.CD40 (而非196-15.CD28.CD40)轉導之對照細胞亦因應於LoVo-OKT3顯示增強之IL-2及CXCL10產生。
信號傳導結構域分析：使用指示信號傳導結構域變異CoStAR (MFE23.CD28、MFE23.CD28.CD40、MFE23.CD8ec/tm.CD28.CD40、MFE23.CD8ec/tm.CD40、MFE23.CD8ec/tm.CD137.CD40、MFE23.CD8ec/tm.CD137、MFE23.CD8ec/tm.CD2.CD40、MFE23.CD8ec/tm.CD2)或196-14.CD28.CD40 (陰性對照) CoStAR轉導自三個單獨健康供體分離之原代人類T細胞。CD8ec/tm指示包括來自CD8 (例如SEQ ID NO:20)之間隔體及跨膜結構域之組分。經由CD34細胞表面標記物富集轉導細胞並與LoVo-OKT3細胞一起培育過夜，然後經由ELISA分析細胞培養上清液。MFE23.CD28.CD40所產生IL-2多於MFE23.CD28，MFE23.CD8ec/tm.CD28.CD40之反應性極類似於MFE23.CD28.CD40，從而證實間隔體結構域之選擇不影響CoStAR活性。將CD40添加至MFE23.CD8ec/tm.CD137或MFE23.CD8ec/tm.CD2中會增強該等受體關於IL-2產生以及其他細胞介素及趨化介素之產生之比活性，由此證實添加CD40會改良基於除CD28外之受體信號傳導結構域之CoStAR之活性。
為確定有助於CoStAR活性之CD40增強之受體信號傳導模體，生成在TRAF6結合模體(MFE23.CD28.CD40 (PQEINF突變至AQAINF))、TRAF2結合模體(MFE23.CD28.CD40 (SVQE突變至AVQA))或TRAF1/2/3/5結合模體(MFE23.CD28.CD40 (PVQET突變至AVAEA))中含有突變之變異受體。亦生成具有三重CD40信號傳導結構域之受體MFE23.CD28.CD40(x3)及具有P227A突變之受體。使用指示CoStAR轉導自三個單獨健康供體分離之原代人類T細胞並經由CD34使細胞富集CoStAR表現。使用LoVo-OKT3細胞設置共培養並收集上清液以用於ELISA及細胞介素/趨化介素珠粒陣列。因應於LoVo-OKT3細胞，所有在三個信號傳導模體中之任一者中含有突變之受體皆顯示減小之效應活性(IL-2及/或CXCL10)。表現CD28.CD40 (X3)受體或P227A突變之細胞因應於LoVo-OKT3顯示增強之活性。
為確定有助於CoStAR活性之CD40增強之受體信號傳導模體，生成在TRAF6結合模體(MFE23.CD28.CD40 (PQEINF突變至AQAINF))、TRAF2結合模體(MFE23.CD28.CD40 (SVQE突變至AVQA))或TRAF1/2/3/5結合模體(MFE23.CD28.CD40 (PVQET突變至AVAEA))中含有突變之變異受體。使用指示CoStAR轉導自三個單獨健康供體分離之原代人類T細胞並經由CD34使細胞富集CoStAR表現。使用LoVo-OKT3細胞設置共培養並收集上清液以供細胞介素分析。
未轉導細胞之IL2產生極低，但在表現野生型MFE23.CD28.CD40 CoStAR之細胞中有所升高。IL2產生並不受SVQE突變、PQEINF突變或Q263A突變顯著影響。然而，PVQET模體之突變對T細胞之IL2產生具有顯著效應。
在使用LoVo-OKT3細胞進行2輪刺激之過程中，同時評價經改造T細胞因應於LoVo-OKT3細胞之增殖。未轉導細胞即使在一輪刺激下亦不存活，而表現野生型受體之細胞14天內之2輪刺激中發生10倍擴增。具有SVQE-AVQA突變或PQEINF-AQAINF突變之細胞顯示降低之增殖發生能力，此現象在具有Q263A突變之細胞中進一步加劇。然而，在TRAF2/3結合區中具有PVQET-AVAEA突變之細胞在2輪刺激中顯示完全不能增殖。 實例6
為評估經具有CD40之CoStAR轉導之T細胞之活體內抗腫瘤活性，模擬轉導原代人類T細胞或使用MOV19.CD28.CD40 CoStAR構築體進行轉導，隨後實施活體外擴增及冷凍保存。MOV19係對葉酸鹽受體α (FolR1)具有高親和力之單鏈Fv抗體。向免疫受損小鼠中植入既定卵巢癌細胞系(A2870、OVCAR-5、OVCAR-8或SK-OV-3)，使該細胞系在動物中生長數天。隨後根據腫瘤負荷對小鼠進行分期，且最後注射經模擬轉導之T細胞或經MOV19.CD28.CD40轉導之T細胞。在T細胞投藥之後不久，向一些小鼠注射靜脈內IL-2 (5μg IL-2, Q2Dx7)以支持T細胞之植入及初始擴增。最終研究設計含有以下5組(每一組含有5隻小鼠)：PBS (未投用細胞)、經模擬轉導之T細胞、經模擬轉導之T細胞與IL-2補充、經MOV19.CD28.CD40轉導之T細胞及經MOV19.CD28.CD40轉導之T細胞與IL-2補充。每週監測腫瘤生長及小鼠存活並總共持續40天。
與模擬轉導組相比，投與MOV19.CD28.CD40轉導細胞之小鼠展示較佳之腫瘤控制及延長存活，不論是否補充IL-2。此數據證實CoStAR平臺能夠在活體內改良T細胞抗腫瘤反應且亦闡釋此改良反應與外源性IL-2之存在無關。 實例7
結合至CEA之CoStAR之設計- CoStAR由具有抑瘤素M1、CD8α、CD2、IL-2、GM-CSF或hIgGκ VIII前導序列之CEA特異性MFE23、人類化(hu) MFE23、CEA6、BW431/26或huT84.66源單鏈抗體片段核苷酸序列組成。每一CoStAR具有衍生自CD8或CD28或截短CD28之細胞外間隔體結構域及衍生自CD28及CD40之信號傳導結構域。將構築體選殖至含有MND啟動子之pSF.Lenti (Oxford Genetics)中，並經由P2A裂解序列與截短CD34標記基因分隔。
結合至MSLN之CoStAR之設計- CoStAR由具有抑瘤素M1、CD8α、CD2、IL-2、GM-CSF或hIgGκ VIII前導序列之MSLN特異性SS1、人類化SS1 (M5)、HN1、M912、HuYP218或P4源單鏈抗體片段核苷酸序列組成。每一CoStAR具有衍生自CD8或CD28或截短CD28之細胞外間隔體結構域及衍生自CD28及CD40之信號傳導結構域。將構築體選殖至含有MND啟動子之pSF.Lenti (Oxford Genetics)中，並經由P2A裂解序列與截短CD34標記基因分隔。
慢病毒產生-使用三質體包裝系統(Cell Biolabs, San Diego, USA)藉由將10 μg每一質體加上10 μg含有轉基因之pSF.Lenti慢病毒質體在含有50 mM CaCl 2之無血清RPMI中一起混合來實施慢病毒產生。將混合物逐滴添加至75 cm 2燒瓶中之50%鋪滿之293T細胞單層中。在轉染後48及72h時收集病毒上清液，彙集並使用Lenti-X慢病毒上清液濃縮液(Takara Bio Inc. Japan)根據製造商說明書來進行濃縮。將慢病毒上清液濃縮10倍並直接用於以MOI 3-5在4 μg/ml聚凝胺(Sigma-Aldrich, Dorset, UK)存在下感染原代人類T細胞。自正常健康供體分離周邊血單核細胞，然後使用T細胞活化及擴增珠粒(Invitrogen)根據製造商說明書來活化24小時，隨後添加慢病毒上清液。
在感染後96小時使用CEA.hFc蛋白及二級抗hFc-PE +抗CD34-APC或僅藉由抗CD34-PE抗體來評價細胞轉導。然後使用x10供體失配之經輻照PBMC飼養細胞以1:200比率在T細胞培養基(RPMI 1640、10% FBS、10mM HEPES、50 μM β-巰基乙醇及50 u/ml青黴素/鏈黴素)、200 IU/ml IL-2及最終濃度為30 ng/ml之抗CD3 (OKT3)中來進一步擴增細胞。在12-14天之後，如先前所述將細胞染色並儲存以備用於分析。
藉由混合CoStAR陽性或陰性細胞與野生型或經OKT3改造之CEA或MSLN陽性細胞系(LoVo, HT29, SW480, H508)來實施功能性分析。簡言之，在96孔板中以不同比率混合T細胞與靶細胞並藉由ELISA及MSD分析來量測細胞介素釋放。
使用xCELLigence RTCA SP實時細胞分析儀系統(Acea)實施細胞毒性分析。在實驗期間(最長250 hr)，生成程式以每15 min測試96孔PET E板之孔電導率(細胞指數)。將50 μL T細胞培養基添加至擬測試細胞指數之孔中並在室溫(RT)下培育30分鐘。將E板添加至RTCA SP器件中並量測背景電導率讀數。
靶細胞之最佳接種密度定義為在開始分析之後24至36小時達到穩定細胞指數且在分析結束之前在無干預(亦即添加Triton-x-100或效應細胞群體)下並不降低者。使用能夠區分死細胞之定量方法對用於殺死分析之最佳密度(依賴於細胞系)下之靶細胞進行計數。自器件取出E板且將最佳密度之活細胞添加至含有T細胞培養基之孔中(最終體積為100 μL)，然後在室溫下培育30分鐘。
然後將E板放置回分析儀上並獲取細胞指數值直至觀察到穩定細胞指數為止，此時中止程式並自RTCA SP器件取出E板。將處理劑添加至適當孔中。處理劑由100 μL T細胞培養基(無處理對照)或含有效應細胞或0.5% Triton-x-100之相同體積(完全溶解對照)組成。效應細胞計數使用能夠區分死細胞及細胞凋亡細胞之定量方法。效應細胞與靶細胞之數量端視實驗而有所變化。
在數據分析期間，使用RTCA軟體包中之下列方程式將細胞指數正規化： 正規化 CIti = CIti/CInml_time
其中CIti =特定時間點下之細胞指數(CI)，且CInml_time =在添加T細胞之前之時間點下之CI。
然後相對於完全溶解對照進一步處理數據以得到細胞裂解%： % Cytolysisst= [1-(NCIst)/(AvgNCIRt)]×100
其中，NCIst係試樣之正規化細胞指數且NCIRt係匹配參考孔之平均正規化細胞指數。
藉由在不存在外源性IL-2下於96孔U形底板之孔中一式三份以8:1 E:T比率混合5×10 4個經CoStAR轉導或模擬轉導之細胞與LoVo-OKT3細胞來實施重複刺激分析。在D1、4及7經由基於αCD2圈選之流式細胞術數量評價來進行T細胞計數，並以7天間隔添加新鮮腫瘤細胞。藉由拆分孔並基於原始接種密度計算倍數變化來評價相對擴增，其中為計數而去除之細胞部分亦考慮在內。 結果
研發模型系統以評估針對CEA及MSLN之CoStAR受體之各種結構組分之影響。為此，評價信號肽(SP)、單鏈抗體片段(scFv)及細胞外間隔體(ES)對表現及功能之影響。
測試信號肽對CoStAR之表現之影響，因已知不同信號肽可影響各種重組蛋白(REF)之表現。使用各種不同前導序列(其編碼期望信號肽)來生成MFE23.CD28.CD40 CoStAR受體。該等前導序列包含衍生自抑瘤素M1 (OSM)、IL2、CD2、CD8α、GMCSF及hIgGκ VIII之信號肽。同框選殖每一前導序列與MFE23 scFv序列以生成SP.MFE23.CD28.CD40.P2A.tCD34。選擇Jurkat細胞系模型來研究每一經SP修飾之CoStAR相對於tCD34標記基因之相對表現。為此，在MOI 5下將Jurkat JRT3-T3.5 T細胞與慢病毒顆粒一起培育。在轉導後7天，使用抗CD34抗體將細胞染色以將轉導細胞染色，且使用CEA.hFc蛋白+抗hFc二級抗體進行染色以鑑別CEA CoStAR。發現所有經SP修飾之測試CoStAR變體皆表現於JRT3-T3.5細胞之CD34+部分中。
接下來，評價不同CEA特異性scFv在CoStAR背景中之影響，且研究不同間隔體結構域。比較6種不同scFv以及上述MFE23序列(Chester等人，1994)，包含MFE23 K＞Q突變體、人類化(Hu) MFE23 (Begent等人，2003)、CEA6 (Jackson等人，1998)、BW431/26 (Seenmann等人，1991)及HuT84.66 (Yazaki等人，2005)。
自獲自NHSBT之膚色血球層來分離原代人類T細胞。藉由Ficoll介導之分離及T細胞陰性分離套組(StemCell Technologies)來分離T細胞。使用人類T細胞活化及擴增珠粒(Invitrogen, UK)活化經分離T細胞。將細胞與編碼含有OSM SP之CEA CoStAR之經濃縮慢病毒顆粒一起培育，並擴增數天。使用抗CD34抗體使細胞富集CoStAR表現以獲得大於90% CoStAR陽性之T細胞群體，然後使用如材料及方法中所概述之經輻照膚色血球層源PBMC來實施快速擴增方案(REP)。
採用生理相關之活體外模型來測試CoStAR對T細胞活性之影響。針對CEA+細胞系LoVo、H508、SW480或HT29來測試經轉導及未轉導之細胞。作為對照，改造鼠類CEA-細胞系Ba/F3以表現CEA。為使得能夠因應於不匹配腫瘤細胞系來活化T細胞，改造腫瘤細胞以表現藉助合成跨膜結構域錨定至細胞膜且使用IRES元件與GFP標記基因分隔之抗CD3單鏈抗體片段，從而使用流式細胞術來觀察轉導細胞。亦改造細胞系以在嘌呤黴素(puromycin)選擇下表現螢火蟲-螢光素酶(ffLuc)，從而允許分析靶細胞溶解。
以不同效應物:靶比率混合未轉導及經CoStAR轉導之T細胞與野生型或經OKT3改造之腫瘤細胞系。在24小時之後，獲取共培養基以供IL-2 ELISA量測。因應於經OKT3改造之細胞自來自所有供體之CoStAR+及CoStAR- T細胞群體皆觀察到活化依賴性IL-2分泌，且因應於未改造腫瘤細胞自經轉導及未轉導之T細胞僅看到背景IL-2分泌。在所測試之所有供體中，存在CEA CoStAR會增強針對經OKT3改造之CEA+腫瘤細胞系之效應活性(IL2, IL3, CXCL10)。
與Ba/F3細胞一起共培養證實了CEA CoStAR之靶向方式。將CEA CoStAR改造細胞與Ba/F3或Ba/F3-CEA一起共培養並不引起特異性IL2釋放，而與Ba/F3-OKT3一起培育則增強了IL-2分泌。然而，與僅Ba/F3-OKT3相比，將T細胞與Ba/F3-OKT3/CEA一起培育會顯著增強IL2分泌。
測定CoStAR對腫瘤細胞殺死之影響。混合經轉導或未轉導之T細胞與野生型或經OKT3-GFP改造之腫瘤細胞並在指定時間點下量化殘餘腫瘤細胞源螢光素酶活性。存在CoStAR會增強T細胞介導靶細胞溶解之能力。使用如材料及方法中所概述之xCELLigence器件測得，CoStAR+細胞介導抗腫瘤活性之此種增強能力亦較為明顯。
根據材料及方法來實施重複刺激分析。簡言之，以8:1 E:T比率混合經模擬或CoStAR改造之細胞與經OKT3改造之靶細胞系並在指示時間點下計算T細胞之相對擴增，其中以7天間隔添加新鮮腫瘤。所測試之所有CoStAR皆在多輪刺激中介導延長存活及T細胞擴增，而模擬轉導細胞之數量在重複刺激後則有所下降。
為評估TIL樣品中之CoStAR活性，使用CEA特異性CoStAR構築體改造TIL。為此，消解腫瘤並使用流式細胞術分析CEA表現。使用CEA CoStAR改造測試為陽性之腫瘤消解物。遵循長出及快速擴增方案，混合經改造及匹配未改造之TIL與腫瘤消解物或(若可用)匹配自體腫瘤細胞系。在所測試之所有供體中，與模擬轉導細胞相比，存在CEA CoStAR會增強特定效應活性，如藉由IFNγ及IL-2所量測。
評價不同MSLN特異性scFv在CoStAR背景中之影響，且研究不同間隔體結構域。比較6種不同scFv：SS1 (Chowdhury, 1999)、人類化(Hu) SS1 (Begent等人，2003, M5) (專利CA2931684A1)、HN1 (Jackson等人，1998)、BW431/26 (Seenmann等人，1991)及HuT84.66 (Yazaki等人，2005Ho, 2011)、M912 (Feng, 2009)、HuYP218 (Zhang, 2015)及P4 (專利US9272002B2)。
自獲自NHSBT之膚色血球層來分離原代人類T細胞。藉由Ficoll介導之分離及T細胞陰性分離套組(StemCell Technologies)來分離T細胞。使用人類T細胞活化及擴增珠粒(Invitrogen, UK)活化經分離T細胞。將細胞與編碼含有OSM SP之MSLN CoStAR之經濃縮慢病毒顆粒一起培育，並擴增數天。使用抗CD34抗體使細胞富集CoStAR表現以獲得大於90% CoStAR陽性之T細胞群體，然後使用如材料及方法中所概述之經輻照膚色血球層源PBMC來實施快速擴增方案(REP)。
採用生理相關之活體外模型來測試CoStAR對T細胞活性之影響。針對MSLN+/-細胞系LoVo (MSLN-)、H508 (MSLN+)、SW480 (MSLN+)或HT29 (MSLN+)來測試經轉導及未轉導之細胞。作為對照，改造鼠類MSLN-細胞系Ba/F3來表現MSLN。為使得能夠因應於不匹配腫瘤細胞系來活化T細胞，改造腫瘤細胞以表現藉助合成跨膜結構域錨定至細胞膜且使用IRES元件與GFP標記基因分隔之抗CD3單鏈抗體片段，從而使用流式細胞術來觀察轉導細胞。亦改造細胞系以在嘌呤黴素選擇下表現螢火蟲-螢光素酶(ffLuc)，從而允許分析靶細胞溶解。
以不同效應物:靶比率混合未轉導及經CoStAR轉導之T細胞與野生型或經OKT3改造之腫瘤細胞系。在24小時之後，獲取共培養基以供IL-2 ELISA量測。因應於經OKT3改造之細胞自來自所有供體之CoStAR+及CoStAR- T細胞群體皆觀察到活化依賴性IL-2分泌，且因應於未改造腫瘤細胞自經轉導及未轉導之T細胞僅看到背景IL-2分泌。在所測試之所有供體中，存在MSLN CoStAR會增強針對經OKT3改造之MSLN+腫瘤細胞系之效應活性(IL2, IL3, CXCL10)。
與Ba/F3細胞一起共培養證實了MSLN CoStAR之靶向方式。將MSLN CoStAR改造細胞與Ba/F3或Ba/F3-MSLN一起共培養並不引起特異性IL2釋放，而與Ba/F3-OKT3一起培育則增強了IL-2分泌。然而，與僅Ba/F3-OKT3相比，將T細胞與Ba/F3-OKT3/MSLN一起培育會顯著增強IL2分泌。
測定CoStAR對腫瘤細胞殺死之影響。混合經轉導或未轉導之T細胞與野生型或經OKT3-GFP改造之腫瘤細胞並在指定時間點下量化殘餘腫瘤細胞源螢光素酶活性。存在CoStAR會增強T細胞介導靶細胞溶解之能力。使用如材料及方法中所概述之xCELLigence器件測得，CoStAR+細胞介導抗腫瘤活性之此種增強能力亦較為明顯。
根據材料及方法來實施重複刺激分析。簡言之，以8:1 E:T比率混合經模擬或CoStAR改造之細胞與經OKT3改造之靶細胞系並在指示時間點下計算T細胞之相對擴增，其中以7天間隔添加新鮮腫瘤。所測試之所有CoStAR皆在多輪刺激中介導延長存活及T細胞擴增，而模擬轉導細胞之數量在重複刺激後則有所下降。
為評估TIL樣品中之CoStAR活性，使用MSLN特異性CoStAR構築體改造TIL。為此，消解腫瘤並使用流式細胞術分析MSLN表現。使用MSLN CoStAR改造測試為陽性之腫瘤消解物。遵循長出及快速擴增方案，混合經改造及匹配未改造之TIL與腫瘤消解物或(若可用)匹配自體腫瘤細胞系。在所測試之所有供體中，與模擬轉導細胞相比，存在相關CoStAR會增強特定效應活性，如藉由IFNγ及IL-2所量測。 實例8 抗MSLN CoStAR表現
對包括不同scFv抗原結合結構域之抗MSLN CoStAR (表8)在來自健康供體之T細胞上之表面表現進行比較。
表8
純系 CTP224 CTP225 CTP226 CTP227 CTP228 CTP229
SEQ ID NO: 192 210 228 246 264 282
信號肽 OSM1
scFv SS1 M5 HN1 M912 huYP218 P4
連接體 AAAGSGGSG
間隔體 CD28 EC
TM CD28
細胞內 CD28.CD40
以感染複數(MOI) 5使用擁有CD28.CD40信號傳導結構域之針對間皮素(MSNL)之6種可變scFV構築體慢病毒轉導來自健康供體(HD) PBMC之T細胞。使用未轉導(模擬)細胞作為對照。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，經由分別使用抗CD34-APC (黑色)或抗MSLN-PE (紅色)抗體表面檢測標記基因tCD34或CoStAR分子來評價1×10 5個細胞之轉導效率。(圖19)。結果代表3個生物重複。 實例9 抗MSLN CoStAR活性
評價與靶細胞系一起共培養之經CoStAR轉導之HD T細胞中之細胞介素產生。測試包括不同抗MSLN結合結構域、間隔體或跨膜結構域之各種CoStAR (表8、表9、表10)。
表9
純系 CTP248 CTP249 CTP250 CTP251 CTP252 CTP253
SEQ ID NO: 300 306 312 318 324 330
信號肽 OSM1
scFv SS1 M5 HN1 M912 huYP218 P4
連接體 AAAGSGGSG
間隔體 截短CD28 EC
TM CD28
細胞內 CD28.CD40
表10
純系 CTP236 CTP237 CTP238 CTP239 CTP240 CTP241
SEQ ID NO: 198 216 234 252 270 288
信號肽 OSM1
scFv SS1 M5 HN1 M912 huYP218 P4
連接體 AAAGSGGSG
間隔體 CD8 EC
TM CD8
細胞內 CD28.CD40
將未轉導(模擬)及經抗MSNL CoStAR轉導之HD T細胞與經改造OVCAR3靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時，且實施MSD免疫分析以評估所分泌細胞介素之濃度。在與OVCAR-3或OVCAR3-OKT3細胞系一起共培養後，測定IL-2 (圖20A)、IFNγ (圖20B)及TNFα (圖20C)之細胞介素濃度。使用未處理T細胞作為對照。結果代表1-3個生物重複，其中每一生物重複具有3個技術重複。
將未轉導(模擬)及經抗MSNL CoStAR轉導之HD T細胞與經改造K562靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時，且實施MSD免疫分析以評估所分泌細胞介素之濃度。在與K562-MSNL或K562-MSNL-OKT3細胞系一起共培養後，測定IL-2 (圖21A)、IFNγ (圖21B)及TNFα (圖21C)之細胞介素濃度。使用未處理T細胞作為對照。結果代表1-3個生物重複，其中每一生物重複具有3個技術重複。 抗CEA CoStAR表現
評估包括不同信號肽(表11)或scFv抗原結合結構域(表12)之抗CEA CoStAR之抗CEA CoStAR表現。
表11
純系 CTP194 CTP255 CTP256 CTP257 CTP258 CTP259
SEQ ID NO: 42 43 44 45 46 47
信號肽 OSM1 CD8 CD2 IL2 GMCSF hIgGκ
scFv MFE23
連接體 AAAGSGGSG
間隔體 CD28 EC
TM CD28
細胞內 CD28.CD40
表12
純系 CTP194 CTP219 CTP220 CTP221 CTP222 CTP223
SEQ ID NO: 42 60 78 96 114 132
信號肽 OSM1
scFv MFE23 MFE23 (Q＞K) hMFE23 CEA6 BW431/26 hT84.66
連接體 AAAGSGGSG
間隔體 CD28 EC
TM CD28
細胞內 CD28.CD40
為檢驗信號肽變體，在感染複數(MOI) 5下使用擁有CD28.CD40結構域之針對癌胚抗原5 (CEA)之MFE23 scFV構築體來慢病毒轉導來自健康供體PBMC之T細胞。構築體之信號肽具有變化且使用未轉導(模擬)細胞作為對照。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，經由分別使用抗CD34-APC (黑條)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)表面檢測標記基因tCD34或CoStAR分子來評價1×10 5個細胞之轉導效率(圖22)。
亦在感染複數(MOI) 5下使用擁有CD28.CD40結構域之針對癌胚抗原5 (CEA)之可變scFV構築體來慢病毒轉導來自健康供體PBMC之T細胞。如上所述，使用未轉導(模擬)細胞作為對照。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，經由分別使用抗CD34-APC (黑條)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)表面檢測標記基因tCD34或CoStAR分子來評價1×10 5個細胞之轉導效率(圖23)。 實例10 抗CEA CoStAR活性
評價與Lovo靶細胞系一起共培養之經CoStAR轉導之HD T細胞中之細胞介素產生。測試包括不同抗CEA結合結構域之CoStAR (表12)。將未轉導(模擬)及經抗CEA CoStAR轉導之HD T細胞與經改造靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時，且實施MSD免疫分析以評估所分泌細胞介素之濃度。在與Lovo或Lovo-OKT3細胞系一起共培養後，測定IL-2 (圖24A)、IFNγ (圖24B)及TNFα (圖24C)之細胞介素濃度。使用未處理T細胞作為對照。結果代表1個具有3個技術重複之生物重複。
亦評價與K562靶細胞系一起共培養之經CoStAR轉導之HD T細胞中之細胞介素產生。如上所述，將細胞與經改造靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時並實施MSD免疫分析以評估所分泌細胞介素之濃度，且在與K562.CEACAM5或K562.CEACAM5.OKT3細胞系一起共培養後，測定IL-2 (圖25A)、IFNγ (圖25B)及TNFα (圖25C)之細胞介素濃度。使用未處理T細胞作為對照。
亦檢驗間隔體-跨膜變體。在一實驗中，對包括hMFE23 CEA結合結構域及不同間隔體/跨膜結構域之抗CEA CoStAR (表13)進行比較。
表13
純系 CTP220 CTP232 CTP244
SEQ ID NO: 78 84 162
信號肽 OSM1
scFv hMFE23
連接體 AAAGSGGSG
間隔體 CD28 EC CD8 EC CD28 (trunc IIH)
TM CD28 CD8 CD28
細胞內 CD28.CD40
在感染複數(MOI) 5下使用擁有CD28.CD40結構域之針對癌胚抗原5 (CEA)之hMF23 scFV構築體來慢病毒轉導來自健康供體PBMC之T細胞。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，經由使用抗CD34-APC (黑條)表面檢測標記基因tCD34或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)檢測CoStAR分子來評價1×10 5個細胞之轉導效率(圖26)。所有變體皆得以有效表現。
評價與Lovo靶細胞系一起共培養之經CoStAR轉導之HD T細胞中之細胞介素產生。如上所述，將細胞與經改造靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時並實施MSD免疫分析以評估所分泌細胞介素之濃度，且在與Lovo或Lovo-OKT3細胞系一起共培養後，測定IL-2 (圖27A)、IFNγ (圖27B)及TNFα (圖27C)之細胞介素濃度。使用未處理T細胞作為對照。 實例11
構築CoStAR以測試細胞內信號傳導結構域。圖28及表14繪示包括hMFE23 CEA結合結構域與細胞內信號傳導結構域之抗CEA CoStAR，該等細胞內信號傳導結構域包括CD40、CD134、CD137、CD2、ICOS、DAP10及NTRK1信號傳導元件。
表14
純系 CTP313 CTP314 CTP315 CTP316 CTP317
SEQ ID NO: 344 345 346 347 348
信號肽 OSM1
scFv hMFE23
連接體 AAAGSGGSG
間隔體 CD28 EC ICOS
TM CD28 ICOS
細胞內 NTRK1 NTRK1 CD40 CD28 NTRK1 CD28 NTRK1 CD40 ICOS CD40
  
純系 CTP318 CTP319 CTP320 CTP321 CTP322 CTP323
SEQ ID NO: 349 350 351 352 353 354
信號肽 OSM1
scFv hMFE23
連接體 AAAGSGGSG
間隔體 CD28 EC CD2 EC CD28 EC
TM CD28 CD2 CD28
細胞內 CD28 ICOS CD28 ICOS CD40 CD2 CD40 CD28 CD2 CD28 CD40 CD2 CD28 CD137
  
純系 CTP324 CTP325 CTP326 CTP327 CTP328
SEQ ID NO: 355 356 357 358 359
信號肽 OSM1
scFv hMFE23
連接體 AAAGSGGSG
間隔體 CD28 EC
TM CD28
細胞內 CD28 CD40 CD137 CD28 DAP10 CD28 CD40 DAP10 CD28 CD134 CD28 CD40 CD134
在感染複數(MOI) 5下使用針對癌胚抗原5 (CEA)之hMF23 scFV構築體來慢病毒轉導來自健康供體PBMC之T細胞。使用未轉導(模擬)細胞作為對照。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，經由分別使用抗CD34-APC (黑色)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(紅色)表面檢測標記基因tCD34或CoStAR分子來評價1×10 5個細胞之轉導效率(圖29)。結果代表3個生物重複。
在表型上表徵CoStAR轉導細胞。在長出及REP後，使用流式細胞術評價1×10 5個細胞之分化亞型。
表15 T細胞分化亞型定義
TN CD45RO- CCR7+ CD95-
Tscm CD45RO- CCR7+ CD95+
Tcm CD45RO+ CCR7+ CD95+
Tem CD45RO+ CCR7- CD95+
Tte CD45RO- CCR7- CD95+
Tcm，中央記憶性T細胞；Tem，效應記憶性T細胞；Tn，初始T細胞；Tscm，幹細胞記憶性T細胞；Tte，末端效應性T細胞
使用圖28之hMF23 scFV構築體慢病毒轉導來自三個供體之HD PBMC之T細胞。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在長出及REP後，使用流式細胞術評價與未轉導細胞相比1×10 5個細胞之分化亞型。T細胞表型以CD3細胞之比例形式繪示於圖30中。 實例12
藉由與K562靶細胞一起共培養來評價經抗CEA hFME23 CoStAR轉導之T細胞之細胞介素分泌。將未轉導(模擬)及經抗CEA CoStAR轉導之HD T細胞與經改造靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養24小時，且實施MSD免疫分析以評估所分泌細胞介素之濃度。展示在與K562.CEACAM5 (信號2)或K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養後IL-2 (圖31A)、IFNγ (圖31B)及TNFα (圖31C)之細胞介素濃度。使用未處理T細胞作為對照。
亦評價細胞介素表現。將未轉導(模擬)及經抗CEA CoStAR轉導之HD T細胞與經改造靶細胞系以1:1之效應物對靶(E:T)比率(1×10 5: 1×10 5)在佈雷菲德菌素A存在下一起共培養16小時，且使用細胞內流式細胞術量測細胞介素產生細胞。展示在與K562.CEACAM5 (信號2)或K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養後IL-2 (圖32A)、IFNγ (圖32B)及TNFα (圖32C)表現細胞之頻率。使用未處理T細胞作為對照。 實例13 抗CEA CoStAR轉導細胞之增殖
使用hMFE23抗CEA CoStAR轉導HD T細胞並與經改造靶細胞一起共培養。在第0天，將未轉導(模擬)及經抗CEA CoStAR轉導之HD T細胞與經K562.CEACAM5.OKT3改造之靶細胞系以8:1之效應物對靶(E:T)比率(1×10 5: 1.25×10 4)一起共培養。使用未轉導(模擬)細胞作為對照。在第7天，使用經K562.CEACAM5.OKT3改造之靶細胞系以8:1之E:T再刺激最多50000個細胞。在刺激後第5天、第7天及第9天，收集一部分共培養物以藉由流式細胞術進行計數。對於所有計數而言，使用DRAQ7來區分活細胞且使用CD2來對T細胞進行計數(圖33)。各圖代表輸入細胞之倍數擴增。N= 2
對上述經hMFE23抗CEA CoStAR轉導並與經K562.CEACAM5.OKT3改造之靶細胞系一起共培養之HD T細胞進行採樣以在第6天進行計數，從而評估倍數擴增(圖34)。藉由流式細胞術使用DRAQ7 (用於活細胞區分)及CD2 (用以對T細胞進行計數)對細胞進行計數。 實例14
信號轉導以及細胞內結構域結合位點及模體。
檢驗CD40之TRAF2/TRAF3及TRAF6結合位點(圖35)之突變對經CD28.CD40 CoStAR轉導之T細胞之細胞介素分泌以及長期存活及增殖的效應。使用Dynabeads活化三個供體之細胞並使用WT CD28.CD40 (CTP194)、含有TRAF2結合位點突變SVQE＞AVQA (CTP195)、TRAF2/TRAF3結合位點突變PVQET＞AVAEA (CTP196)、TRAF6結合位點突變PQEINF＞AQAINF (CTP197)、Q263A (CTP199)之CD28.CD40進行轉導，或實施模擬轉導。使細胞富集CD34標記物表現，遵循快速擴增方案(REP)進行擴增並冷凍以用於後續實驗。在解凍之後，將細胞在補充有IL-2之完整RPMI中靜置3-4天且通過觀察CD34標記基因表現來測定其轉導速率。在過夜IL-2饑餓之後使用DRAQ-7 (1:200)藉由流式細胞術(Novocyte)來評價生存力及絕對計數，且使用NovoExpress 1.5.0軟體分析數據。將經轉導T細胞在不存在IL-2下與LoVo (來自ATCC之CCL-229 TM)或LoVo.OKT3.GFP腫瘤細胞以8:1效應物對靶比率一起共培養。在24小時之後，收集上清液並冷凍。LoVo及LoVo.OKT3.GFP在其表面上自然表現CEA及PD-L1，從而將信號2經由CoStAR單獨或與信號1 (LoVo.OKT3.GFP)結合賦予經轉導T細胞。一式三份實施共培養且在實驗中包含相應陰性(僅T細胞、僅腫瘤細胞)及陽性(PMA +離子黴素)對照。在解凍之後，藉由ELISA檢測經分泌IL-2且使用FLUOstar Omega微量板讀數儀量測吸光度，且隨後使用Omega MARS 3.42 R5軟體進行分析(圖36A)。每一點代表一個供體之三個重複之平均值。應注意，陰性對照(僅T細胞、僅腫瘤細胞)皆低於檢測範圍。
在6-8天之後，評價生存力及絕對計數，且使用如上文所闡述之新鮮LoVo.OKT3.GFP腫瘤細胞將活T細胞再攻擊一週。在長期共培養結束時，量測生存力及絕對計數，且計算倍數擴增(圖36B)。數據展示為n≤3個供體之平均值+/- SEM，其中一式三份地進行分析。
TRAF2結合位點之突變(SVQE＞AVQA; CTP195)引起較小IL-2分泌降低及中等擴增降低。TRAF2/TRAF3結合位點之突變(PVQET＞AVAEA; CTP196)引起IL-2分泌及擴增之實質性降低。TRAF6結合位點之突變(PQEINF＞AQAINF; CTP197)引起中等IL-2分泌降低及中等擴增降低。 實例 15
使用24天方案生成未轉導(非Td)及經抗FOLR1 CoStAR轉導(Td)之TIL。簡言之，將OC消解物之等分試樣解凍並使用抗FOLR1 CoStAR慢病毒以感染複數(MOI) 5來轉導48h及72h。然後將細胞擴增8天(長出)，且然後使用同種異體經輻照周邊血單核細胞(PBMC)實施快速擴增方案(REP) 12天。
在產生之後，量測TIL CD4/CD8比率及抗FOLR1 CoStAR轉導效率。使用流式細胞術面板在表型上表徵TIL之分化狀態、共抑制及共刺激標記物表現、T細胞子組及細胞介素產生潛力。
用於長出之完整TIL T細胞培養基(TCM)由450 mL GIBCO定製P158718培養基與50 mL熱滅活胎牛血清、慶大黴素(gentamycin) (10 μg/mL) /兩性黴素(amphotericin) (0.25 μg/mL)及萬古黴素(vancomycin) (50 µg/mL)組成。完整快速擴增方案(REP)培養基由460 mL GIBCO定製P158718與40 mL人類AB血清、慶大黴素(10 μg/mL) /兩性黴素(0.25 μg/mL)及萬古黴素(50 µg/mL)組成。
抗FOLR1 CoStAR OC TIL之生成
使用5份OC試樣生成經抗FOLR1 CoStAR修飾之TIL。TIL之長出期為12天。在第1天(D1)，將來自每一供體之試樣在完整TIL TCM中解凍，藉由以400 × g離心5分鐘來將細胞洗滌一次，再懸浮於新鮮TIL TCM中並計數。使用DRAQ7染料及抗CD2抗體染色劑且使用Novocyte 3005流式細胞儀系統來實施所有細胞計數。然後以400 × g將TIL離心5分鐘，以1 × 10 6細胞/mL之濃度再懸浮，置於含有3000 IU/mL IL-2之適當容器中並在設定於37℃之5% CO2培育器中靜置兩天。
在靜置期後第3天，收集細胞，洗滌，以400 × g離心5分鐘，並再懸浮於中新鮮完整TCM中。如上文所闡述使用Novocyte 3005來測定每一試樣中之活細胞數，以400 × g將細胞離心5分鐘並以1 × 10 6細胞/mL之濃度再懸浮。將每一試樣分成兩等份，一份用於產生非Td TIL且另一份用於經修飾以表現抗FOLR1 CoStAR之經轉導(Td) TIL。基於活細胞數以MOI 5使用抗FOLR1 CoStAR慢病毒進行轉導。以3000 IU/mL之濃度添加IL-2且將細胞置於設定於37℃之5% CO2培育器中。
在第4天，收集細胞，使用完整TIL TCM洗滌一次，並再懸浮於與第3天相同體積之新鮮完整TIL TCM中以供第二天轉導。使用抗FOLR1 CoStAR慢病毒以MOI 5來實施轉導且將3000 IU/mL IL-2添加至細胞中，然後將其置於設定於37℃之5% CO2培育器中並保持8天。每2-3天將IL-2 (3000 IU/mL)添加至細胞中直至D13。
在第13天，收集細胞，洗滌，再懸浮於完整TIL TCM中並使用Novocyte 3005計數。在測定TIL數量之後第13天，將細胞接種於適當規模之G-REX板中以使用10個健康供體之經輻照同種異體PBMC作為飼養細胞以200:1之飼養細胞:TIL比率來實施REP。用於REP之培養基係完整REP TIL TCM，其中以30 ng/mL之濃度添加抗CD3 (OKT3)抗體以供活化。以3000 IU/mL之濃度添加IL-2且將細胞置於設定於37℃之5% CO2培育器中。REP期為12天，在此期間每2-3天補充IL-2 (3000 IU/mL)。
在第19天(亦即REP之第6天)，自24孔G-REX板去除5 mL培養基或自6孔G-REX板去除25 mL培養基而不擾亂細胞，並更換為新鮮完整REP TIL TCM及IL-2 (3000 IU/mL)。在D25，於REP結束時，藉由以400 × g離心5分鐘來收穫TIL並再懸浮於新鮮培養基中以使用Novocyte 3005進行計數。以1 × 10 6個細胞/mL之濃度再懸浮TIL。然後藉由使用針對CD3、CD4、CD8、CoStAR及活性染色劑之抗體將每一試樣之1 × 10 5個細胞染色來評價TIL之轉導效率。使用DNeasy Blood & Tissue套組遵循製造商說明書自來自每一試樣之1 × 10 6個細胞提取DNA。使用微滴式數位PCR (ddPCR)及對抗FOLR1 CoStAR及參考基因Poly(rC)結合蛋白2 (PCBP2)具有特異性之引子且使用經分離DNA來分析載體拷貝數(VCN)。在後續實驗中，將2-5 × 10 7個細胞含有IL-2 (3000 IU/mL)之新鮮完整REP TIL TCM中靜置3天。將剩餘TIL再懸浮於冷凍保護劑中並等分至冷凍小瓶中，冷卻至-80℃過夜，且然後轉移至-150℃下以供短期儲存。將經冷凍保存之TIL在37℃水浴中解凍，使用PBS藉由以400 × g離心5分鐘來洗滌一次，然後經歷如上文所闡述之相同靜置期，隨後進行實驗。 來自4個供體之抗FOLR1 CoStAR OC TIL之表型表徵。
將來自4個供體之非Td及Td細胞在含有IL-2 (3000 IU/mL)之REP TCM培養基中靜置3天。隨後，收穫細胞，使用培養基藉由以400 × g離心5分鐘來洗滌一次，再懸浮於新鮮完整REP TIL TCM中，使用Novocyte 3005計數，並以1 × 10 6個細胞/mL之濃度再懸浮。一式三份使用4個流式細胞術面板對每一孔之1 × 10 5個細胞實施細胞術TIL評估。使用具有針對CD3、CD4、CD8、CD27、CD95、CCR7、CD45RA、CD45RO、CoStAR及活性染色劑之抗體之面板來評價分化狀態。使用針對以下各項之抗體來評價共抑制及共刺激標記物表現：CD4、CD8、CD137、程式化細胞死亡蛋白1 (PD-1)、細胞毒性T淋巴球相關蛋白4 (CTLA-4)、淋巴球活化基因3 (LAG-3)、T細胞免疫球蛋白及黏蛋白結構域蛋白3 (TIM-3)、信號傳導淋巴球活化分子(SLAM)、CoStAR及活性染色劑。使用針對CD3、CD4、CD25、叉頭盒蛋白3 (FOXP3)、T細胞受體α β (TCRαβ)、T細胞受體γ δ (TCRγδ)、CD56、CD127、CoStAR及活性染色劑之抗體來評價細胞亞群體(包含Treg)。使用針對CD3、CD4、CD8、IL-22、TNFα、IL-17A、IFNγ、CoStAR及活性染色劑之抗體來評價促有絲分裂刺激時之細胞介素產生。對於此面板而言，藉由添加PMA (50 ng/mL) /離子黴素(1 μg/mL)及佈雷菲德菌素A (1000 x)來活化TIL，且置於設定於37℃之5% CO2培育器中並保持4小時。在活化後，收集TIL，以400 × g離心5分鐘，計數，且一式三份接種1 × 10 5個細胞以供流式細胞術分析。對於所有流式細胞術面板而言，使用BD Cytofix/Cytoperm根據製造商說明書來實施固定及滲透。在染色後，洗滌細胞並再懸浮於PEF (500 mL DPBS、2 mL EDTA及2.5 mL熱滅活FBS)中以使用Novocyte 3005流式細胞儀系統進行分析。 非Td及Td細胞之分析
對於表型表徵之4個面板而言，使用具有Fc標籤之重組人類FOLR1 (rhFOLR1-FC)來檢測抗FOLR1 CoStAR細胞，且報告所關注群體，亦即非Td TIL之CoStAR-子組及Td TIL之CoStAR-及CoStAR+級分(抗FOLR1 CoStAR- Td TIL及抗FOLR1 CoStAR+ Td TIL)。對該等群體實施其他子組表徵。 分化狀態
用於表徵T細胞分化狀態之圈選策略如下：淋巴球門、隨後雙重及死細胞排除、CD3+、CD4+及CD8+門。對來自所有三個群體(CD3+、CD4+及CD8+)之所關注T細胞級分實施進一步分析。為表徵不同T細胞記憶子組，自CD3+細胞圈選CD45RA+CD45RO-及CD45RA-CD45RO+細胞。然後自CD45RA-CD45RO+細胞圈選CD45RO+CCR7+及CD45RO+CCR7-群體。使用該等門，進一步圈選中央記憶性T細胞(Tcm; CD45RO+CCR7+CD95+CD27+)細胞及效應記憶性T細胞(Tem; CD45RO+CCR7-CD95+CD27+/-)細胞。另外，自CD45RA+CD45RO-細胞圈選CD45RA+CCR7+及CD45RA+CCR7-群體。使用該等門，自CD45RA+CCR7+細胞圈選幹細胞記憶性T細胞(Tscm; CD45RA+CCR7+CD95+CD27+)及初始T細胞(Tn; CD45RA+CCR7+CD95-CD27+)，同時自CD45RA+CCR7-細胞圈選末端效應性T細胞(Tte; CD45RA+CCR7-CD27-CD95+)細胞。 共抑制及共刺激標記物
用於表徵共抑制及共刺激分子之圈選策略包含雙重及死細胞排除。圈選CD4+及CD8+以及CoStAR+/-細胞且進一步分析各群體之CD137、PD-1、CTLA-4、LAG-3、TIM-3及SLAM表現。 T細胞亞型
用於表徵T細胞亞型之圈選策略包含雙重及死細胞排除以及CD3+門。使用該等群體，評價TCRαβ、TCRγδ及CD56之表現。隨後，針對TCRαβ及CD56之表現來圈選CD3+CD4+細胞，且進一步分析CD3+CD4+TCRαβ+群體之CD25及CD127表現。使用CD25+CD127-門，圈選FOXP3+細胞以確定Treg群體。因此，端視所評價群體，Treg定義為CD3+TCRab+CD4+ CD25+CD127-FOXP3+及CoStAR+/-。 促有絲分裂刺激時之細胞介素產生
用於表徵細胞內細胞介素產生之圈選策略包含雙重及死細胞排除、CD3+、CD4+及CD8+門。對不同群體實施CoStAR表現分析，隨後進一步分析表現IL-22、IL-17A、TNFα及IFNγ之細胞之頻率。 臨床特性
來自5名卵巢癌患者之TIL之臨床特性展示於表 16中。患者皆未經治療，且特異性組織學揭示三例漿液性囊腺癌、一例子宮內膜樣癌及一例透明細胞腺癌。試樣重量介於0.55-2.62克之間且平均重量為2.39±1.31克。在處理之後，以6 × 10 6- 2.5 × 10 7個細胞及1 mL/小瓶冷凍保存試樣。在第1天，將試樣解凍並使用流式細胞術計數，其中CD2+ TIL之平均百分比為19.5±9.43。解凍試樣中所收穫之總TIL介於4.4 × 10 5-3.3 × 10 6個細胞之間。
表16 卵巢腫瘤試樣資訊
ID 腫瘤類型/組織學 腫瘤重量 標記物 臨床階段 TNM 等級 處理狀態
1 卵巢癌/漿液性囊腺癌- M-84413 2.62 CA125 - 937    IB T1b - N0 - M0 G2 -中度分化 未處理   
2 卵巢癌/漿液性囊腺癌-M-84413 0.55 CA125 - 478,83    IV T3 - Nx - M1 G3 -分化不良 未處理   
3 卵巢癌/漿液性囊腺癌- M-84413 4.2 CA125 - 50,53    IIB T2b - Nx - M0 G3 -分化不良    未處理   
4 卵巢癌/子宮內膜樣癌-M-83803 2.1 CA125 - 1096 HE4 - 1487    IC T1c - Nx - M0 G2 -中度分化 未處理   
5 卵巢癌/透明細胞腺癌-M-83103 2.5 CA125 - 187    IIIC T3c - Nx - M0 G3 -分化不良 未處理   
縮寫：ID，編號；CA125，癌症抗原125；TNM，腫瘤、結節、轉移。
在TIL產生之後，比較非Td及Td TIL之細胞數以評價抗FOLR1 CoStAR修飾對TIL生長之任何效應。結果展示對TIL之細胞數並無顯著影響(圖38)。在TIL產生之後評價經轉導CD3+、CD4+及CD8+細胞之比例(圖39A-C)。CD4細胞所展示之轉導百分比(50.8 ±15.2%)高於CD8細胞(32.7± 20.6%)，且此結果係統計學顯著的(p= 0.384)。另外，使用ddPCR評價VCN以檢測相對於PCBP2參考基因之CoStAR轉基因，且量測每一細胞之＜ 4個整合(圖39)。產物中之CD4及CD8群體組成之對比指示，大部分細胞係CD4+細胞(其中含量介於53.0-58.7%之間)且CD8+細胞較少(30.8-38.2%)。亦檢測到低含量之CD4+CD8+及CD4-CD8-細胞，其分別介於3.47-4.43%及3.19-6.97%之間。非Td、抗FOLR1 CoStAR- Td及抗FOLR1 CoStAR+ Td TIL之間關於CD4/CD8細胞組成並無顯著差異(圖40)。
進一步表徵TIL以確定抗FOLR1 CoStAR修飾是否影響TIL功能。評價非Td、抗FOLR1 CoStAR- Td及抗FOLR1 CoStAR+ Td TIL之CD3+、CD4+及CD8+ T細胞隔室中之Tn、Tscm、Tcm、Tem及Tte之組成(圖41A-C)。結果展示，在CD3+ (63.2-78.6%)、CD4+ (76.9-88.8%)及CD8+ (48.3-66.9%)群體中，大部分TIL係Tem。CD3+、CD4+及CD8+ TIL之Tcm細胞頻率分別介於6.28-15.7%、6.72-17.5%及5.18-11.7%之間。Tte細胞佔全部CD3+ TIL之14.8-15.9%。該等細胞主要存在於CD8+亞群體中且頻率為22.1-25.1%，與之相比在CD4+亞群體中為2.68-3.79%。在CD3+、CD4+及CD8+ TIL中檢測到較少Tscm細胞且頻率分別為0.15-1.38%、0.05-0.50%及0.53-3.24%。頻率最低之記憶性亞型係Tn細胞，且所有三個群體中之該等細胞之頻率介於0.002-0.019%之間。非Td、抗FOLR1 CoStAR- Td及抗FOLR1 CoStAR+ Td TIL之間關於Tn、Tem、Tcm或Tte頻率並無顯著差異。儘管Tscm TIL較低，但與抗FOLR1- Td TIL (而非非Td TIL)相比，在CD3+ (0.15±0.05% vs 1.38±0.69%)及CD4+ (0.05±0.02% vs 0.51±0.27%)群體之抗FOLR1+ Td TIL中檢測到顯著更低之Tscm TIL。總而言之，數據展示，抗FOLR1 CoStAR修飾並不顯著影響TIL之分化狀態。
評價CD8+及CD4+ TIL之CD137、PD-1、CTLA-4、LAG-3、TIM-3及SLAM之表現(圖42)。在CD4+ TIL中，所有三種所關注群體之LAG-3、PD-1、SLAM及TIM-3之表現分別在39.8-47.7%、61.0-64.4%、52.7-57.6及65.6-72.1%之範圍內。在CD8+ TIL中，LAG-3、PD-1、SLAM及TIM-3之表現分別介於86.7-88.2%、38.2-46.5%、61.5-67.2%及90.0-94.3%之間。CD4+及CD8+細胞之CTLA-4分別介於8.92-15.2%及4.10-7.29%之間，且CD137分別為2.80-8.30%及7.70-17.1%。
三種TIL群體非Td、抗FOLR1 CoStAR- Td及抗FOLR1 CoStAR+ Td TIL之對比指示，抗FOLR1 CoStAR對CD4+ TIL中之共抑制及共刺激標記物表現並無效應。在CD8+ TIL中，與非Td及抗FOLR1 CoStAR- Td TIL相比，抗FOLR1+ Td中之CD137+ (17.1±8.79% vs 7.70±3.92% vs 7.77±4.01%)及CTLA-4+ (7.29±2.41% vs 4.66±1.51% vs 4.10±1.07%)細胞之頻率較高。PD-1+ TIL頻率僅高於抗FOLR1- Td TIL，但並不高於非Td TIL (分別為46.5±21.1% vs 38.2±19.6% vs 40.6±26.8%)。總而言之，除CD8+ CD137+、CTLA4+及PD-1+ TIL之頻率發生輕微但顯著之增加外，TIL之CoStAR修飾對共抑制或共刺激標記物表現具有較小觀察效應。
除TCRαβ及TCRγδ之表現外，亦在TIL試樣中使用用於Treg檢測之標記物來評價T細胞子組頻率。大部分CD3+細胞表現TCRαβ (90.0-93.5%)且檢測到相對較少之TCRγδ細胞(1.35-3.08%) (圖43A)，並且在三個群體之間並未觀察到差異。CoStAR-或CoStAR+ TIL中之Treg (CD3+TCRαβ+CD4+CD25+CD127-FOXP3+)之百分比皆極低。具體而言，非Td、抗FOLR1 CoStAR-及抗FOLR1 CoStAR+ Td TIL之檢測頻率分別為0.63±0.48%、0.66±0.36%及0.93±0.63% (圖43B)。總而言之，在比較非Td、抗FOLR1 CoStAR- Td及抗FOLR1 CoStAR+ Td TIL時，抗FOLR1 CoStAR對TCRαβ、TCRγδ及Treg頻率並無效應。
評價TIL細胞在使用PMA/離子黴素進行促有絲分裂活化時產生細胞介素之能力。使用PMA/離子黴素將非Td及Td TIL活化4小時且然後針對CD3+、CD4+及CD8+細胞之IFNγ、IL-22、IL-17A及TNFα進行染色。在刺激後，檢測到高頻率之表現TNFα (61.8-73-6%)及IFNγ (32.5-42.0%)之CD3+ TIL及較低頻率之IL-22 (4.74-8.07%)及IL-17A (5.74-11.0%)表現細胞(圖44A)。抗FOLR1 CoStAR+ Td中之TNFα+細胞之頻率高於抗FOLR1 CoStAR- Td TIL (73.6±14% vs 61.8±18.3%)，但並不高於非Td TIL (72.1±9.20%)。
在CD4+ TIL中，檢測到高頻率之TNFα表現細胞(54.3-67.2%)及較低頻率之IFNγ (19.3-26.2%)、IL-22 (7.63-10.5%)及IL-17A (12.0-20.2%)表現細胞(圖44B)。抗FOLR1 CoStAR+ Td中之TNFα+ (67.2±15.5% vs 54.3±17.2%)及IL-17A+細胞(20.2±11.3 vs 12.0±7.06)之頻率高於抗FOLR1 CoStAR- Td TIL。據觀察，在比較抗FOLR1 CoStAR +/- Td TIL與非Td TIL時，表現TNFα或IL-17A之CD4+之頻率並無顯著差異。
針對CD8+ TIL群體獲得類似觀察，其中檢測到高TNFα (62.7-86.7%)及IFNγ (45.3-63.0%)以及較低IL-22 (6.80-17.0%)及IL-17A (6.93-15.3%)頻率之陽性細胞(圖44C)。在此群體中，與抗FOLR1 CoStAR- TIL相比，在抗FOLR1 CoStAR + Td TIL中關於TNFα (86.7±8.37% vs 62.7±18.2%)、IL-17A (15.3±7.24% vs 6.93±2.77%)及IL-22 (17.0±6.90% vs 6.80±2.48%)鑑別到較高頻率之細胞介素表現細胞。同樣，據觀察，在抗FOLR1 CoStAR+/- Td TIL與非Td TIL之間並無顯著差異。
在CD4+及CD8+亞群體中所觀察之IL-17A+抗FOLR1 CoStAR + Td TIL與抗FOLR1 CoStAR-Td TIL之間之顯著差異在CD3+大群體中並非統計學上顯著的(p=0.0527)。總而言之，在CD3+、CD4+或CD8+ TIL群體內於觀察到抗FOLR1 CoStAR +/-Td細胞群體之間IL-17A、IL-22及TNFα表現細胞之比例之一些統計學顯著的差異。然而，在比較Td群體(亦即抗FOLR1 CoStAR -/+級分)與非Td TIL時，未觀察到IFNγ、IL-17A、IL-22及TNFα產生細胞之頻率之顯著差異。 實例 16CoStAR陽性TIL之抗腫瘤反應性
完整快速擴增方案(REP)培養基由補充有40 mL人類AB血清、慶大黴素(10 μg/mL) /兩性黴素(0.25 μg/mL)及萬古黴素(50 µg/mL)之460 mL GIBCO定製P158718組成。完整T細胞培養基(TCM)由補充有5 mL青黴素-鏈黴素、500 μL 2-巰基乙醇(50 mM)及50 mL胎牛血清(FBS)之450 mL RPMI 1640 GlutaMAX™補充HEPES培養基組成。 用於功能表徵之經CoStAR修飾之OC TIL之製備
如ITIL-306-NC-010中所闡述來產生來自5份OC試樣之非Td及Td TIL且轉導百分比展示於表17中。
表17 非Td及Td TIL供體
供體 非Td中之CD3之CoStAR% Td中之CD3之CoStAR%    符號
1 0.98 34.00 ■
2 0.11 24.33 ●
3 0.20 47.11 ▼
4 0.09 45.65 ▲
5 0.15 64.60 ◆
TIL在REP之後直接使用或在自長期冷凍保存(-150℃；儲存於由FBS與10% DMSO組成之冷凍保護劑中)解凍後使用。使用37℃水浴將卵巢癌TIL解凍，轉移至含有10 mL完整REP TCM之50 mL Falcon管中，以400 × g離心5分鐘並再懸浮於完整REP TCM中。在DRAQ7死細胞排除及CD2+計數後，使用NovoCyte 3005流式細胞儀系統對REP後及解凍後TIL進行計數，並以1×10 6個細胞/mL之密度置於T75燒瓶中補充有3000 IU/ml介白素2 (IL-2)之完整REP TCM中。然後將細胞置於設定於37℃之5% CO2培育器中並保持2-3天。在分析之前，以1x10 6細胞/mL之密度在無IL-2下將TIL再懸浮於完整REP TCM中並置於設定於37℃之5% CO2培育器中過夜。 自體腫瘤消解物之FOLR1表現之評價。
使用37℃水浴將所有自體腫瘤消解物自長期冷凍保存(-150℃；儲存於由FBS與10% DMSO組成之冷凍保護劑中)解凍，轉移至含有9 mL完整TCM之15 mL Falcon管中，以400 × g離心5分鐘並再懸浮於5 mL完整TCM中。在DRAQ7死細胞排除後使用NovoCyte 3005流式細胞儀系統測定每一試樣中之活細胞數，且以1×10 6個細胞/mL之濃度將細胞再懸浮於完整TCM中。然後根據流式細胞術染色方案來分析1×10 5個自體腫瘤消解細胞並使用Novocyte 3005流式細胞儀系統獲取。
根據下列圈選策略來量化FOLR1表現：細胞門(正向散射-高度[FSC]-H vs側向散射-高度[SSC]-H)，然後雙重排除門(SSC-H vs側向散射-面積[SSC-A])，隨後死細胞排除門(SSC-A vs固定活性染料eFluor 450)。然後圈選自其量化FOLR1+細胞之頻率之CD2細胞(SSC-A vs FOLR1-PE)。 藉由細胞內流式細胞術評價之細胞介素產生
為量測產生細胞介素之T細胞之頻率，將非Td及抗FOLR1 CoStAR Td TIL以1:1效應物對靶比率(E:T, 1×10 5TIL : 1×10 5個靶細胞)與自體腫瘤消解物、K-562或OVCAR-3源經改造細胞系(作為靶)一起共培養。共培養發生於具有補充有1x佈雷菲德菌素A之200 μL完整TCM之96孔圓底板中，且在設定於37℃之5% CO2培育器中培育16小時。使用單獨之未刺激TIL或靶細胞作為陰性對照，且使用50 ng/mL佛波醇肉豆蔻酸乙酸酯(PMA)及1 μg/mL離子黴素活化陽性對照TIL。所有條件皆一式三份來實施。
使用具有針對CD3、CD4、CD8、CoStAR (抗獨特型19.1一級及抗小鼠IgG1二級抗體)、腫瘤壞死因子α (TNFα)、IL-2及活性染色劑之抗體之面板來量測細胞介素產生。在16小時培育後，藉由以500 × g離心4分鐘來收穫共培養物。棄除上清液，且藉由流式細胞術分析試樣。簡言之，使用100 μl固定活性染料(以1:1000稀釋於PBS中)標記細胞並在室溫下培育10分鐘。隨後，使用BD染色緩衝液洗滌細胞，以500 × g離心4分鐘，且在室溫下將細胞糰粒再懸浮於100 μl含有FcR封閉試劑之BD染色緩衝液中並保持10分鐘。在培育步驟後，使用BD染色緩衝液將細胞洗滌一次並使用4%低聚甲醛(PFA)在室溫下固定15分鐘。使用BD perm/wash緩衝液洗滌，使用19.1抗獨特型在4℃下染色25分鐘且隨後使用BD perm/wash緩衝液再洗滌兩次。然後將細胞再懸浮於100 μl含有CD3、CD4、CD8、抗小鼠IgG1、TNFα及IL-2之BD染色緩衝液中並在4℃下培育25分鐘。在使用BD perm/wash緩衝液再進行兩個洗滌步驟後，將細胞糰粒再懸浮於100 μl BD染色緩衝液中以在NovoCyte 3005流式細胞儀系統上進行獲取。
根據包含死細胞排除之圈選策略來量化CD4及CD8亞群體中之TNFα及IL-2產生細胞頻率。自活門圈選CD3+細胞(SSC-A vs CD3-A)且然後自CD3+門圈選CD4+及CD8+細胞(CD4-A vs CD8-A)。報告非Td TIL之CoStAR陰性(-)子組及Td TIL之CoStAR-及CoStAR陽性(+)級分(抗FOLR1 CoStAR- Td TIL及抗FOLR1 CoStAR+ Td TIL)中之TNFα及IL-2產生細胞。 藉由MSD免疫分析評價之細胞介素產生
為量測細胞介素分泌，將非Td及抗FOLR1 CoStAR Td TIL以1:1比率(E:T, 1×105 TIL : 1×10 5個靶細胞)與自體腫瘤消解一起及以8:1比率(E:T, 1×10 5TIL : 1.25×10 4個靶細胞)與K-562或BA/F3源經改造細胞系一起共培養。一式三份在200 μL完整TCM中實施共培養。在實施MHC封閉之實驗中，將自體腫瘤消解物與針對I類MHC (HLA-ABC; 40 μg/mL)、II類MHC (HLA-DRDPDQ; 40 μg/mL)、I + II類MHC (皆40 μg/mL)或同型對照(小鼠IgG2a; 80 μg /mL)之抗體一起在100 μL完整TCM中預培育(4℃) 45分鐘。在培育後，將TIL添加至適當孔中。在所有實驗中，使用單獨之未刺激TIL或靶細胞作為陰性對照，且使用經50 ng/mL佛波醇肉豆蔻酸乙酸酯(PMA)及1 μg/mL離子黴素活化之TIL作為陽性對照。然後將細胞置於設定於37℃之5% CO2培育器中並保持24小時。
在24小時培育後，以400 × g將試樣離心5分鐘，且收穫上清液，然後儲存於-80℃下。在解凍後，將試樣適當地稀釋於來自Meso scale discovery (MSD)之 V-Plex Plus Proinflammatory Panel 1套組之完整TCM及稀釋劑2中。根據製造商說明書來實施分析。 藉由流式細胞術評價之靶細胞細胞毒性
為量測TIL之細胞毒性活性，將非Td及抗FOLR1 CoStAR Td TIL以1:1比率(E:T, 1×10 5TIL : 1×10 5個靶細胞)與BA/F3源經改造細胞系一起共培養。共培養以一式三份實施於具有200 μL完整TCM之96孔圓底板中，並在設定於37℃之5% CO2培育器中培育20小時。單獨培養TIL及靶細胞以作為陰性對照。
在20小時共培養後，以400 × g將試樣離心5分鐘，棄除上清液，且藉由流式細胞術分析試樣。簡言之，使用100 μl固定活性染料(以1:1000稀釋於PBS中)標記細胞並在室溫下培育10分鐘。使用BD染色緩衝液實施所有洗滌。在培育之後，洗滌細胞，以500 × g離心4分鐘，且在室溫下將細胞糰粒再懸浮於100 μl含有FcR封閉試劑之BD染色緩衝液中並保持10分鐘。在培育步驟後，將細胞洗滌一次，再懸浮於100 μl含有CD2之BD染色緩衝液中並在4℃下培育25分鐘。將細胞洗滌兩次，且將細胞糰粒再懸浮於100 μl BD染色緩衝液中以在NovoCyte 3005流式細胞儀系統上進行獲取。
在雙重及死細胞排除之後藉由流式細胞術計算靶細胞計數。自活門(SSC-A vs CD2-A)圈選CD2細胞並藉由NovoCyte 3005流式細胞儀系統之絕對計數函數進行量化。 藉由xCELLigence評價之靶細胞細胞毒性
藉由xCELLigence根據製造商說明書來評價靶細胞細胞毒性。簡言之，藉由向每一孔中添加50 μL TCM來平衡E板，在室溫下培育30分鐘，且在RTCA分析儀(37℃, 5% CO 2)上獲取背景電阻抗。此後，將於50 μL TCM中之3×10 4個OVCAR-3源經改造細胞系添加至每一E板之每一孔中並在室溫下培育30分鐘，然後在RTCA分析儀(37℃, 5% CO 2)上藉由電阻抗(細胞指示)來評價細胞生長。在整個分析期間，每15分鐘量測細胞指數。在達到鋪滿時(24-31小時之間)，將於100 μL TCM中之6x10 3或1×10 3個非Td或Td TIL添加至OVCAR-3源經改造細胞系中(E:T比率分別為1:5及1:30)。將該等細胞在室溫下培育30分鐘，然後在RTCA分析儀(37℃, 5% CO 2)上進一步讀取細胞指數169小時。對照條件包含含有僅靶細胞系、靶細胞系與在OC TIL加載時間點下添加之0.5% Triton X-100 (完全溶解對照)及僅TIL之孔。使用RTCA software pro根據製造商說明書來測定正規化細胞指數(NCI)。將OC TIL與OVCAR-3源經改造細胞系之共培養物在169小時時段中之NCI曲線下面積(如自RTCA software pro所獲得)報告為定量讀出。使用RTCA SP及DP。對於1:30比率之非Td及Td TIL與9831及9260腫瘤消解物而言，一式兩份來運行共培養。 分析
在自冷凍保存之腫瘤試樣產生TIL並表徵後，將所保留輸入腫瘤消解試樣解凍並評價FOLR1、抗FOLR1 CoStAR之配體之其表現。在所有5種腫瘤中之CD2-細胞表面上皆可檢測到FOLR1，其中FOLR1陽性細胞之比例介於5.44-22.1%之間(圖45)。
使用細胞內流式細胞術評價識別自體腫瘤並對其具有反應之T細胞之頻率。使用PMA/I刺激作為能夠易於產生IL-2及TNFα之TIL之頻率之陽性對照。在僅與佈雷菲德菌素A一起培養過夜(16小時)之腫瘤消解物中未檢測到IL-2+或TNFα+ TIL。與之相比，在將擴增TIL與自體腫瘤消解物一起共培養16小時後檢測到IL-2+及TNFα+ TIL (圖46)。CD4+抗FOLR1 CoStAR+ Td TIL之特徵在於IL-2產生細胞之頻率顯著高於非Td TIL且顯著增加6.56倍(12.0±12.9% vs 1.83±0.55%) (圖46A)。儘管並不顯著，但與抗FOLR1 CoStAR- Td TIL相比，CD4+抗FOLR1 CoStAR+ Td TIL之IL-2產生細胞頻率亦增加3.33倍(12.0±12.9% vs 3.61±3.10%)。在單獨培養時亦檢測到，相對於抗FOLR1 CoStAR- Td TIL (2.58 ±1.60%)而非非Td TIL (3.31±3.62%)，產生TNFα之抗FOLR1 CoStAR+ CD4 T細胞(6.96 ±3.56%)之數量發生輕微但顯著之增加(圖46C)。在與自體消解物一起共培養時，抗FOLR1 CoStAR+ Td TIL群體中之TNFα+細胞之頻率似乎有所增加，但未觀察到與抗FOLR1 CoStAR- Td及非Td TIL相比之統計學顯著性差異(32.3% vs 17.8% vs 11.6%)。
在與自體消解物一起共培養時，針對CD8+群體獲得類似觀察(圖46A-D)。相對於抗FOLR1 CoStAR- Td TIL (1.42±1.00%；2.9倍增加)而非非Td TIL (1.11±0.55%；4.13倍增加，p=0.1097)，針對抗FOLR1 CoStAR+ Td TIL檢測到顯著較高之CD8+ IL-2+細胞頻率(4.13±2.26%) (圖46B)。抗FOLR1 CoStAR+ Td TIL中之CD8+ TNFα產生細胞之頻率高於抗FOLR1 CoStAR-Td及非Td TIL，然而，該等差異未達到統計學顯著性(22.6% vs 12.5% vs 10.5%) (圖46D)。
總而言之，在使用自體消解物刺激時，CoStAR修飾顯著增加了產生IL-2之CD4+及CD8+細胞之頻率。在相同環境中，產生TNFα+之CD4+及CD8+細胞之頻率具有類似趨勢，但未達到統計學顯著性。
實施MSD免疫分析以評價在一起共培養TIL與自體消解物時釋放之細胞介素之量(圖47A-D)。使用PMA/I刺激作為細胞介素產生之陽性對照，經CoStAR修飾之TIL與非Td TIL之間之細胞介素產生類似。TIL之CoStAR修飾使得與非Td TIL相比因應於自體腫瘤之IL-2、TNFα、IL-13及IFNγ分泌發生統計學顯著性增加(圖47A-D)。在單獨培養時觀察到Td TIL與非Td TIL之背景細胞介素含量具有增加趨勢(圖47A-D)且僅IL-2較為顯著(70.6 pg/mL vs 31.8 pg/mL) (圖47A)。在與自體消解物一起共培養時，儘管Td TIL中之IL-2分泌顯著高於非Td TIL (74.1 pg/mL vs 32.1 pg/mL)，但此結果與單獨培養TIL之背景含量不同。Td TIL因應於自體消解物所分泌之IFNγ含量高於非Td TIL，其中產生含量為8287 pg/mL vs 1970 pg/mL (圖11D)。類似地，相對於非Td TIL，在將Td TIL與自體消解物一起共培養時，檢測到較高含量之TNFα (55.0 pg/mL vs 18.2 pg/mL，圖47B)及IL-13 (152 pg/mL vs 48.4 pg/mL，圖47C)。該等結果指示，經CoStAR修飾之Td TIL之TNFα、IFNγ及IL-13產生分別增加3-、4.2-及3.1倍。
在由經CoStAR修飾之TIL在與自體腫瘤物一起共培養時釋放之IFNγ與表現FOLR1之腫瘤消解物之比例之間觀察到統計學顯著性正相關性(r 2= 0.9191) (圖47E)。此相關性未觀察於非Td TIL中，從而證實CoStAR-FOLR1相互作用係TIL增強之關鍵。此外，經CoStAR修飾之TIL之IFNγ釋放得以增強，即使針對FOLR1陽性細胞頻率低至5.44%之卵巢腫瘤(圖11E)。
MHC封閉抗體可防止TCR與其靶銜接並介導TCR信號傳導。為評價經CoStAR修飾之TIL之MHC限制性抗原識別，將非Td及Td TIL與自體腫瘤消解物在MHC封閉或不相關同型對照抗體存在下一起共培養，且藉由IFNγ釋放來量測TIL抗腫瘤活性(圖48)。因CoStAR修飾增強了因應於自體腫瘤之細胞介素產生(圖47)，故評價相對於在無封閉劑下與自體消解物一起共培養之TIL之減小百分比。在任一評價條件中，非Td TIL與Td TIL之間之細胞介素釋放百分比並不顯著不同。相對於在不存在抗體下與自體消解物一起共培養之TIL，封閉MHCI、MHCII及MHCI及MHCII之組合之抗體顯著降低了非Td (分別為32.7%、43.1%及43.1%)及Td TIL (分別為35.0%、27.0%及27.3%)之IFNγ釋放。另外，封閉試劑對細胞介素釋放之抑制引起在任一封閉條件與單獨TIL之間並不顯著不同之減小。相對於在不存在抗體下與自體消解物一起共培養之TIL，同型對照抗體對Td (79.1%)或非Td TIL (92.7%)之IFNγ釋放具有較小效應。MHC封閉抗體對TIL IFNγ釋放之降低與同型對照相比係統計學顯著的且抑制程度在Td TIL與非Td TIL之間並非統計學顯著性不同，從而證實了對MHC限制性抗原識別之同等依賴性。
使用多種經改造細胞系來評價穩定TIL效應功能及CoStAR增強該等功能之全部潛力(表18)。改造K-562及BA/F3細胞系以表現表面結合之OKT3 (以誘導CD3介導之信號1)或FOLR1 (CoStAR介導之信號2)或OKT3及FOLR1二者(用於信號1及2)。另外，改造內源性表現FOLR1 (63.68% FOLR1+)之卵巢癌細胞系OVCAR-3以表現表面結合之OKT3。使用該等細胞系，共培養非Td及Td TIL以分別藉由評估細胞介素產生來評價CoStAR介導之效應功能之影響且藉由細胞內流式細胞術及MSD免疫分析來評價分泌。
表 18 經改造細胞系
親代細胞系 製造商 衍生/改造細胞系
K-562 ATCC K-562 (無信號) K-562-OKT3 (信號1) K-562-FOLR1 (信號2) K-562-OKT3-FOLR1 (信號1及2)
OVCAR-3 ATCC OVCAR-3 (信號2) OVCAR3-OKT3 (信號1及2)
BA/F3 DSMZ BA/F3 (無信號) BA/F3-OKT3 (信號1) BA/F3-FOLR1 (信號2) BA/F3-OKT3-FOLR1 (信號1及2)
使用細胞內流式細胞術來對在與經改造K-562及OVCAR-3細胞系一起共培養16小時之後之細胞介素產生細胞進行計數(圖49)。在所有所關注群體中，CD4+ (1.47-4.17%)及CD8+ (0.23-3.73%)細胞因應於K-562及K-562-FOLR1之IL-2產生細胞頻率最小(圖49A)。對於CD4+及CD8+細胞群體而言，與K-562-OKT3一起培養分別獲得23.0-34.0%及20.0-39.7%之IL-2+細胞頻率。在與對照細胞系一起共培養時，在非Td及抗FOLR1 CoStAR+/-群體之間並未觀察到IL-2產生細胞頻率之統計學顯著性差異，CD8+抗FOLR1 CoStAR+ Td TIL除外，其頻率高於抗FOLR1 CoStAR- Td TIL但不高於非Td TIL (分別為39.7±21.7% vs 20.0±15.1% vs 24.8±13.4%)。相對於抗FOLR1 CoStAR- Td及非Td TIL，與K-562-OKT3-FOLR1細胞系一起共培養使得CD4+ IL-2產生性抗FOLR1 CoStAR+ Td TIL之頻率顯著較高且分別顯著增加1.84-及2.38倍(分別為54.9±20.5% vs 29.9±19.4% vs 23.1±13.4%)。針對CD8+ IL-2+細胞頻率亦具有相同觀察且抗FOLR1 CoStAR+ Td TIL與抗FOLR1 CoStAR- Td及非Td TIL相比分別增加2.53-及2.29倍(分別53.0±23.9 vs 21.0±15.5% vs 23.2±12.2%)。
單獨培養或與OVCAR-3一起共培養之TIL之特徵在於，CD4+ (0.78-1.38%)及CD8+ (0.22-0.80%)群體中之IL-2產生細胞之頻率較小(圖49A)。在使用由OVCAR-3-OKT3細胞系提供之兩種信號刺激時，據觀察，與抗FOLR1 CoStAR- Td TIL (22.4±14.0%)及非Td TIL (15.9±9.47%)相比，CD4+群體中之抗FOLR1 CoStAR+ Td TIL (39.1±14.5%)之IL-2產生細胞之頻率顯著增加且分別增加1.74-及2.46倍。類似地，在CD8+群體中，與抗FOLR1 CoStAR- Td TIL (12.9±10.2%)及非Td TIL (14.5±9.58%)相比，抗FOLR1 CoStAR+ Td TIL (34.1±13.2%)顯示IL-2產生細胞頻率分別增加2.65-及2.36倍。
與K-562-OKT3一起共培養之抗FOLR1 CoStAR+ Td TIL中之CD4+ TNFα陽性細胞頻率顯著高於抗FOLR1 CoStAR- Td TIL (75.9±8.35% vs 66.2±5.04%)，且與K-562-FOLR1一起共培養者顯著高於非Td TIL (12.6±7.08% vs 0.73±0.34%) (圖49B)。在相同條件中針對CD8+ TNFα陽性細胞群體未觀察到顯著性。使用表現兩種信號之K-562-OKT3-FOLR1進行刺激所產生之TNFα產生CD4+細胞頻率高於抗FOLR1 CoStAR- Td (增加1.31倍)及非Td TIL (增加1.39倍) (分別為89.3±6.15% vs 68.1±4.99% vs 64.2±14.0%)。在CD8+群體中觀察到相同趨勢，然而，僅在比較抗FOLR1 CoStAR+ Td TIL與抗FOLR1 CoStAR- Td TIL (1.25倍增加)而非非Td TIL (1.14倍增加)時達到統計學顯著性(分別為90.2±5.35 vs 72.2±9.92% vs 79.3±6.30%)。
在僅培養TIL之條件中，針對CD4+ (5.81±3.38% vs 1.85±1.42%)及CD8+ (4.85±2.46% vs 1.53±0.76%)細胞群體，在抗FOLR1 CoStAR+ Td TIL與抗FOLR1 CoStAR- Td TIL之間觀察到較小但顯著之TNFα百分比差異(圖49B)。在任一群體中，與非Td TIL相比並無顯著差異。在OVCAR-3表現信號2存在下，相對於抗FOLR1 CoStAR- Td及非Td TIL，在抗FOLR1 CoStAR+ Td TIL中檢測到輕微但顯著較高之CD4+ TNFα+細胞頻率(分別為8.29±4.34% vs 1.00±0.78% vs 0.40±0.23%)。與之相比，在CD8+細胞中之該等群體之間未觀察到差異。重要的是，在共培養TIL與OVCAR-3-OKT3細胞系時，與抗FOLR1 CoStAR+ Td TIL (67.4±5.35%)及非Td TIL (60.9±10.9%)相比，在抗FOLR1 CoStAR+ Td TIL (83.5±6.99%)中檢測到顯著較高之CD4+ TNFα產生細胞頻率且分別增加1.24-及1.37倍。在CD8+細胞群體中檢測到類似頻率，其中在抗FOLR1 CoStAR+ Td TIL與抗FOLR1 CoStAR- Td TIL之間增加1.31倍(88.5±3.72% vs 67.8±10.3%)且在抗FOLR1 CoStAR+ Td TIL與非Td TIL之間增加1.21倍(88.5±3.72% vs 73.2±4.57%)。
總而言之，該等結果證實，在與表現兩種信號之經改造細胞系一起共培養時，與CoStAR-級分及非Td TIL相比，經修飾TIL之CoStAR+級分中之IL-2+及TNFα+細胞之頻率顯著增加。儘管較少，但在CD4+及CD8+細胞中觀察到較高頻率之TNFα+細胞群體之一定背景。類似地，在與K-562-OKT3細胞系一起共培養時觀察到CoStAR效應之一定增強(藉由CD8+ IL-2+及CD4+ TNFα+細胞之較高頻率)，此可潛在地藉由K-562上之低FOLR1表現含量來予以闡釋。
除藉由流式細胞術評價活化T細胞之頻率外，亦使用MSD免疫分析來評估在與K-562及BA/F3經改造細胞系一起共培養時所分泌細胞介素之含量(表18)。在與野生型細胞系或經改造以僅表現信號2者一起共培養物時之細胞介素分泌最低(圖50)。Td TIL (2682 pg/mL)中由K-562-OKT3-FOLR1細胞系刺激之IL-2釋放高於非Td TIL (521.5 pg/mL)且顯示5.14倍之增加(圖50A)。類似地，在與BA/F3-OKT3-FOLR1一起共培養之TIL中，Td TIL中之IL-2分泌係非Td TIL之9.31倍(圖50A)。在與K-562-OKT3-FOLR1 (2337 pg/ml vs 1211 pg/mL，1.93倍增加)及BA/F3-OKT3-FOLR1 (900.3 pg/mL vs 278.0 pg/mL，3.24倍增加)一起共培養時，亦與非Td TIL相比在Td TIL中檢測到顯著較高之TNFα產生。
在使用表現兩種信號之細胞系刺激時，IL-13及IFNγ產生亦顯著較高(圖50C-D)。更具體而言，因應於使用K-562-OKT3-FORL1之刺激，Td TIL所分泌之IL-13含量(1590 pg/mL)高於非Td TIL (587.0 pg/mL)，此展示OKT3-FORL1 Td TIL之分泌高2.71倍。類似地，據觀察，OKT3-FORL1 Td TIL (194559 pg/mL)中之IFNγ量係非Td TIL (86183 pg/mL)之2.26倍。類似地，在相同條件中，與非Td TIL相比，與BA/F3-OKT3-FOLR1一起共培養之Td TIL中之IL-13及IFNγ濃度顯著升高，其中細胞介素分泌分別大4.35- (983.9 pg/mL vs 226.1 pg/mL)及5.13倍(65594 pg/mL vs 12786 pg/mL) (圖50C-D)。有趣的是，在與K-562-OKT3一起共培養時，與非Td TIL相比，在Td TIL中觀察到顯著較高之IFNγ分泌(1.33倍增加，98804 pg/mL vs 74917 pg/mL)，此可歸因於K-562細胞上之低FOLR1表現含量。
為測定CoStAR修飾對TIL之細胞毒性能力之影響，分別針對BA/F3及OVCAR-3經改造細胞系來實施基於流式細胞術及基於xCELLigence之殺死分析(圖51)。在藉由流式細胞術評價之共培養中，OKT3足以誘導細胞毒性，此乃因非Td及Td TIL特異性殺死表現OKT3或OKT3及FOLF1二者之BA/F3細胞且未檢測到顯著差異(圖51A)。重要的是，針對BA/F3或BA/F3-FOLR1未觀察到細胞毒性，從而證實需要信號1來誘導殺死。在與OVCAR-3細胞(作為靶細胞系)一起共培養時，使用RTCA分析亦具有類似觀察(圖51B)。在與表現兩種信號之OVCAR-3 OKT3一起共培養時，於所測試之任何E:T比率下，非Td TIL與Td TIL之間之AUC (NCI ×小時)並無顯著差異。單獨之OVCAR-3細胞在早期時間點下並未消除，然而，在後續時間點下以1:5 E:T比率添加非Td或Td TIL後5個供體中之4者中之OVCAR-3細胞之NCI略有降低。
總而言之，該等數據證實缺乏具有CoStAR之TIL針對僅表現CoStAR靶之靶細胞介導之細胞毒性。TCR之銜接足以介導所有分析中之非Td及Td TIL之細胞毒性，從而展示在強效信號1 (例如OKT3)存在下CoStAR對細胞毒性並無影響。 實例17 材料及方法
以8:1之效應物對靶比率(E:T, 1×105個細胞: 1.25×104個細胞)來設置細胞系之共培養。以1×106個細胞/ mL將T細胞再懸浮於完整TCM中並以100 μL/孔來使用。以1.25 ×105個細胞/ mL將靶細胞系再懸浮於完整TCM中並以100 μL/孔來使用。將單獨T細胞及單獨靶設定為陰性對照。將經PMA (50 ng / mL) /離子黴素( 1μg / mL)刺激之T細胞設定為陽性對照。將100 μL/孔添加至單獨TIL、單獨靶及經PMA/I刺激之TIL中。每一孔之最終體積為200 μL。在可能時設置三個重複。將細胞在37℃下培育24小時。在培育後24小時，以400 × g將板旋轉5分鐘。收集上清液並將60 μL每一等分試樣分佈至3 × 96孔U形底板中。在-80℃下冷凍上清液，各使用3份板等分試樣。根據製造商說明書來使用來自MSD之V-PLEX Proinflammatory Panel 1人類套組。將每一試樣之一份等分試樣解凍以供使用。在RPMI培養基中實施初始稀釋，且使用稀釋劑2根據製造商說明書來實施最終稀釋。
以1e5個活T細胞/孔來評估CoStAR表現細胞。將細胞離心(400g, 5 min)，隨後去除上清液(輕彈)並在200 uL PBS中洗滌細胞，離心(400g, 5 min)並去除上清液(輕彈)。將細胞再懸浮於100 uL經稀釋LiveDead活性染料(1:1000，於PBS中)中並在室溫下於暗處培育15 min。將100 uL PEF添加至細胞中且將細胞離心(400g, 5 min)，去除上清液(輕彈)且在200 uL PEF中洗滌細胞，離心(400g, 5 min)且去除上清液(輕彈)。5)將細胞再懸浮於100 uL經稀釋FcR封閉劑(1:100，於PEF中)中並在室溫下於暗處培育15 min。將100 uL PEF添加至細胞中且將細胞離心(400g, 5 min)，去除上清液(輕彈)且在200 uL PEF中洗滌細胞，離心(400g, 5 min)且去除上清液(輕彈)。將細胞再懸浮於100 uL經稀釋抗體預混液中並在4℃下於暗處培育25 min。將細胞離心(400g, 5 min)，去除上清液(輕彈)且在200 uL PEF中洗滌細胞，離心(400g, 5 min)且去除上清液(輕彈)。將100 uL PEF添加至細胞中且將細胞離心(400g, 5 min)，去除上清液(輕彈)且在200 uL PEF中洗滌細胞，離心(400g, 5 min)且去除上清液(輕彈)。將100 uL PEF添加至細胞中且獲取流式細胞術結果。 結果
為評估MSLN作為CoStAR靶之相關性，在各種癌細胞類型(包含原發性腫瘤及轉移性腫瘤)中評估mSLN表現。評估結果展示於圖61A-B中，其中多個試樣中之間皮素+細胞%接近100%，但4種所測試癌症類型(子宮頸SSC、胃腺癌、NSCLC SSC、NSCLC NOS)除外，其展示具有至少50%之間皮素+細胞之重複。
因此，研發具有抗MSLN scFv之CoStAR。6種包括相同連接體、間隔體、TM及細胞內結構域但擁有針對MSLN之不同scFv之不同CoStAR繪示於圖62中。藉由量測用於MSLN-PE及CD34之標記物來評估T細胞中之CoStAR表現。圖62顯示CD34及MSLN-PE之高表現，不論何種scFv包含於CoStAR中。CD34及MSLN-PE表現之流式細胞術繪圖顯示，CD34及rhMSLN-PE雙陽性T細胞之百分比介於12.87-46.59%之間(參見圖63A-B)。藉由評估針對CD4及CD8 T細胞進一步圈選之MSLN-PE及CD34之表現來進一步檢驗經轉導T細胞中之CoStAR表現(參見圖64)。如可在圖64中看到，CD4表現含量與可在CD3中看到者相當，而對於所有scFv而言，CD8細胞中之CD34表現略有降低。或者，在CD34分選後，對轉導細胞實施快速擴增方案(REP) 14天(參見圖65)。與觀察於圖64中者類似，CD4表現含量與可在CD3中看到者相當，然而，CD8細胞中之CD34表現含量高於先前可在無REP下看到者(參見圖65)。來自亦涉及使用REP擴增之MSLN CoStAR之單獨實驗之數據呈現於圖66中，該圖展示三個生物重複中之CD34及MSLN-PE之高表現含量。
為評估靶向MSLN之CoStAR之功能，使用用於6種MSLN靶向CoStAR中之1者之慢病毒轉導供體PBMC。使轉導細胞長出，隨後實施CD34選擇及12天REP，且隨後與表現MSLN及OKT3之天然Ovcar3細胞系一起共培養，其中藉由CoStAR表現細胞來評估細胞介素釋放(參見圖67)。經由流式細胞術評估Ovcar3及Ovcar3-OKT-3細胞中之MSLN表現(參見圖68)。圖66顯示，Ovcar3及Ovcar3-OKT-3細胞MSLN表現含量類似，分別為37.49及36.6%之MSLN陽性細胞。
在將CoStAR表現細胞與Ovcar及Ovcar-OKT3細胞一起共培養時，評價經表現不同scFv結構域及CD8間隔體或截短CD28間隔體之scFV抗MSLN CoStAR轉導並與K562細胞系一起共培養之健康供體T細胞中之細胞介素表現(圖69)。圖69展示，IL-2、IFNγ及TNFα之最佳表現需要信號1及信號2，如藉由Ovcar3-OKT-3細胞中之穩定反應及Ovcar3細胞中之弱反應所證實。另外，具有CD8間隔體或截短CD28間隔體之CoStAR皆能夠產生穩定細胞介素反應(參見圖69)。
在圖70中實施類似實驗，其中使用具有不同scFv及CD28、截短CD28或CD28間隔體結構域之CoStAR來轉導健康供體T細胞。將CoStAR表現細胞與K562-MSLN或K562-MSLN-OKT-3細胞一起共培育且評估細胞介素釋放。圖70展示，CoStAR表現細胞中之IL-2、IFNγ及TNFα之最佳表現需要信號1及信號2，如藉由K562-MSLN-OKT-3細胞中之穩定反應及K562-MSLN細胞中之弱反應所證實。另外，與截短CD28及CD8結構域相比，具有CD28間隔體之CoStAR表現細胞展現略高之IL-2及IFNγ分泌(圖70)。 實例18 材料及方法
將腫瘤消解物在補充有10% FBS、1X慶大黴素/兩性黴素(500X原液)、50 ug/mL萬古黴素及3000 IU/mL IL2之TCM基礎培養基中解凍。以0.5或1 × 10 6個細胞/mL之濃度再懸浮細胞以供接種。對於每一試樣而言，以0.5M/mL將細胞接種於24孔板中或以1M/2mL接種於6孔板中。接種細胞，使一個孔用於非Td TIL生成且另一孔用於抗CEA CoStAR-Td TIL生成。將細胞置於具有5% CO 2之37℃加濕培育器中。在第3及4天，在0.1mL培養基(用於24孔板)或0.5mL培養基(用於6孔板)中稀釋適當體積之慢病毒並添加至擬轉導孔中。在第8天，向細胞中供給補充有10% FBS、1X慶大黴素/兩性黴素(500X原液)、50 ug/mL萬古黴素及6000 IU/mL IL2之TCM基礎培養基。在第10天，自所有條件收集細胞並使用Vicell計數。基於細胞計數，在6孔GRex中使用OKT3 (30ng/mL)、IL2 (3000 U/mL)及經輻照飼養細胞以1:200比率在含有8%人類AB血清之TCM基礎培養基中來刺激TIL。在第15天，將細胞轉移至GRex 6M中且添加含有8%人類AB血清及3000 U/mL IL2之TCM基礎培養基。在第18天，對TIL進行計數且對於細胞計數＜1e6個細胞/mL更換培養基或對於細胞計數＞1e6個細胞/mL將條件進行拆分。在所有條件下進行收穫並在第21天冷凍。 結果
本發明實例測試來自4種不同腫瘤類型之T細胞在經靶向CTP386.1或CTP387.1 CEA之CoStAR構築體轉導後之倍數擴增。圖71展示來自不同腫瘤類型之T細胞中之可變擴增程度，其中來自CRC之細胞所具有之擴增通常小於來自NSCLC、OV及MEL腫瘤之細胞。
除擴增外，亦評估兩種構築體之轉導效率且結果展示於圖72中。如圖72中所展示，轉導效率介於大約20-55%之間，其中對於兩種構築體CRC11974具有最高轉導效率且CRC11959具有最低轉導效率。
亦分析各T細胞亞型中之轉導效率。評估CD4及CD8 T細胞之CoStAR轉導效率且結果展示於圖73中。如可在圖73中看到，對於CRC及卵巢腫瘤源T細胞而言CD4細胞中之轉導效率較高，而對於NCSLC及黑色素瘤源T細胞而言CD8 T細胞中之轉導效率較高。
另外，在經2種CoStAR構築體轉導之T細胞中評估T細胞記憶表型。在第21天評估CCR7及CD45RA之表現含量以確定T細胞記憶表型且結果展示於圖74中。 實例19 材料及方法
以1 × 10 6個細胞/mL在TCM (T細胞培養基)中靜置效應性(亦即非Td及Td) T細胞並在37℃及5% CO 2下培育過夜。在共培養當天，收集效應性T細胞並以1 × 10 6個細胞/mL再懸浮。收集靶細胞系(亦即K562 WT、K562 OKT3、K562 CEACAM5及K562 OKT3 CEACAM5)並以1 × 10 5個細胞/mL再懸浮。將50uL T細胞及靶平鋪於96孔U形底板中以達成10:1 E:T比率。使所有孔中之培養基體積為最高200uL。在過夜共培養後，收集板並以400 × g離心5分鐘。自每一孔收集100 mL上清液並儲存於-80℃下，然後使用MSD V-Plex + Proinflammatory Panel 1套組來分析細胞介素含量。根據製造商說明書實施分析並使用MSD discovery workbench軟體實施分析。 結果
在與表現信號1、信號2或信號1及信號2二者之K562靶細胞一起共培養後，對經分選轉導TIL實施功能測試以分析細胞介素釋放。實施實驗且量測IL-2、TNFα及IFNγ之含量，結果展示於圖75-78中。圖75展示CRC細胞之結果，圖76展示NSCLC之結果，圖77展示OV-9962之結果，且圖78展示黑色素瘤源T細胞之結果。在所有TIL來源中，表現信號1及信號2二者之靶細胞所產生之細胞介素含量高於僅具有信號1或2之靶細胞。另外，所誘導之IFNγ含量高於IL-2或TNFα (參見圖75-78)。 實例20 材料及方法
以1 × 10 6個細胞/mL在TCM (T細胞培養基)中靜置效應性(亦即非Td及Td) T細胞並在37℃及5% CO 2下培育過夜。在共培養當天，收集效應性T細胞並以1 × 10 6個細胞/mL再懸浮。收集經輻照靶細胞系(亦即K562 OKT3 CEACAM5)並以0.2 × 10 6個細胞/mL再懸浮。將50uL T細胞及靶平鋪於96孔U形底板中以達成5:1 E:T比率。使所有孔中之培養基體積為最高200uL。在37℃及5% CO 2下培育板並每週使用靶再刺激。
使用每週(亦即第7、14、21、28及35天)使用靶再刺激，自每一孔收集20uL細胞懸浮液以使用Vicell獲得細胞計數並評價倍數擴增。收集50uL細胞懸浮液以進行染色並評估CoStAR表現含量。以400 × g將剩餘細胞懸浮液離心5 min並棄除上清液。將細胞糰粒再懸浮於50uL培養基中。以1 × 10 6個細胞/mL再懸浮經輻照K562 OKT3 CEACAM5細胞系。然後基於所獲得效應細胞計數以5:1比率將靶添加至每一孔中。使所有孔中之培養基體積為最高200uL，並在37℃及5% CO 2下培育一週直至下一輪再刺激。 結果
在每週使用K562 OKT3 CECAM5靶細胞刺激後，在CoStAR轉導細胞中評估倍數擴增及轉導效率。實施評估且結果展示於圖79-82中。圖75展示CRC 11959及CRC 11974細胞之結果，圖76展示NSCLC 9332及NSCLC 9596之結果，圖77展示OV-9962之結果，且圖78展示MEL CC50、MEL 11909及MEL 17614源T細胞之結果。如可在圖79-82中看到，與未轉導細胞相比，與靶細胞一起共培育之CoStAR表現細胞展示增強之增殖，尤其係經CTP387.1構築體轉導之細胞。第21或28天之轉導效率介於大約20-80%之間，其中OV9662細胞中之轉導效率最低且可在MEL CC50及MEL 17614中看到兩種構築體之高轉導程度。 實例21 材料及方法
下列實例提供關於上述實例17之細節，其結果呈現於圖70A及70B中。對經CEACAM或MSLN ScFv轉導且與CEACAM及MSLN K562細胞系一起共培養之HD T細胞實施細胞介素表現分析。此工作之第一目標在於評價在共培養經候選抗CEA scFv轉導之T細胞與表現CEACAM5 (僅信號2)或CEACAM5/OKT3 (信號1 + 2)之K562.luc.puro細胞系時細胞介素表現(T細胞功能)是否增強。使用MSD量測每一經scFv構築體(MFE23、MFE23 (Q＞K)、hMFE23、CEA6、BW431/26及hT84,66)轉導之T細胞之IL-2、IFN-y或TNF-a含量。利用K562.luc.CEACAM5及K562.luc.puro.OKT3.GFP.CEACAM5，此乃因其應提供隨後使用Lovo細胞系之較清潔系統(CEACAM5+)。第二目標在於評價在共培養經候選抗MSLN scFv轉導之T細胞與表現MSLN (僅信號2)或MSLN/OKT3 (信號1 + 2)之K562.luc.puro細胞系時細胞介素表現(T細胞功能)是否增強。使用MSD量測每一經scFv構築體(MFE23、MFE23 (Q＞K)、hMFE23、CEA6、BW431/26及hT84,66)轉導之T細胞之IL-2、IFN-y或TNF-a含量。利用K562.luc.CEACAM5及K562.luc.puro.OKT3.GFP.CEACAM5，此乃因其應提供隨後使用Ovcar3細胞系之較清潔系統(CEACAM5+)。此工作包含使用CoStAR2 CEA ScFv及MSLN ScFv構築體產生HD以評價表現及功能性。以8:1之效應物對靶比率(E:T, 1×105個細胞: 1.25×104個細胞)來設置細胞系之共培養。將所有共培養物培育24小時，然後收集上清液並冷凍。
下文係此實驗關於完成工作之順序之整個過程：1.藉由密度梯度分離使用Ficoll-Paque離心自膚色血球層分離PBMC。2. 使用人類T細胞分離套組(STEMCELL)分離T細胞。3. 轉導T細胞。4. 藉由流式細胞術染色評價轉導。5. 在第5天對細胞進行計數。6. 使用微珠(Milteni Biotec)對細胞進行CD34選擇。7. 在REP前藉由流式細胞術評價轉導。8. T細胞之快速擴增方案(REP)。9. 在REP後藉由流式細胞術評價轉導。10. REP後細胞計數。11. 使用呈現抗原或OKT3之經改造細胞系(K562.luc.puro.CEACAM5、K562.luc.puro.OKT3.GFP.CEACAM5、K562.luc.puro.MSLN或K562.luc.puro.OKT3.GFP.MSLN)設置共培養。12. 使用Meso Scale Discovery (MSD)平臺分析共培養上清液(用以量測IFN-y、IL-2及TNF-a分泌)。 培養基製備
藉由將2 mL EDTA添加至500 mL磷酸鹽緩衝鹽水(PBS)瓶中且隨後添加2.5 mL胎牛血清來製備PEF培養基。藉由將50 mL胎牛血清添加至450 mL RPMI 1640瓶中且隨後添加5 mL青黴素-鏈黴素、5 mL HEPES溶液及500 μL 2-巰基乙醇(50 mM)來製備完整TCM。 T細胞分離前之細胞製備
自210831 4x HD PBMC分離及貯藏中之經處理膚色血球層獲得NBC PBMC。將5小瓶之每一供體PBMC (NBC571, NBC572, NBC573)在37℃水浴中解凍。為最小化細胞在冷凍培養基中解凍所耗費之時間，以5小瓶為一批將小瓶解凍並洗滌。將小瓶之內容物轉移至每一供體之一個50 mL falcon管中並加滿TCM。以400 × g將細胞離心5分鐘並各使用50 mL TCM洗滌一次。使用Vicell-Blu (10 μL試樣+ 190 μL DPBS，1:20稀釋)對細胞進行計數。 T細胞分離
在PEF中洗滌PBMC且然後以5 × 107個細胞/mL再懸浮。使用每一5 mL facs管轉移2 mL再懸浮細胞。使用EasySep™人類T細胞分離套組根據製造商方案來分離T細胞。在分離之後，收集細胞，轉移至2 × 50 mL falcon管中並使用完整TCM洗滌一次。將細胞再懸浮於每一50 mL falcon之20 mL完整TCM中。各獲取10 μL並再懸浮於190 μL PBS中(稀釋度：1:20)。使用ViCELL-Blu對細胞進行計數。 DynaBeads之T細胞活化
自分離步驟收集細胞並轉移於50 mL falcon管上。以400 × g將經分離T細胞離心5分鐘。在完整TCM中洗滌T細胞且然後基於總計數以1 × 106個細胞/mL再懸浮。將T細胞轉移至T75燒瓶中。添加200 IU/mL IL-2 (106 IU/mL原液之1:5000稀釋液)。將CTS Dynabeads™ CD3/CD28磁珠粒再懸浮於小瓶中(亦即渦旋30 sec)。將0.83 μL CTS Dynabeads™ CD3/CD28添加至每ml T細胞懸浮液中(1:3珠粒:細胞比率)。輕輕搖晃培養物以再懸浮Dynabeads並培育48小時。 用於慢病毒轉導之T細胞之製備
將活化T細胞自燒瓶轉移至50 mL falcon管中。並以400 × g離心5分鐘。將細胞各自再懸浮於20 mL完整T細胞中。各獲取10 μL並再懸浮於190 μL PBS中(稀釋度：1:20)。使用ViCELL-Blu對細胞進行計數。以400 × g將細胞離心5分鐘並以1 × 106個細胞/mL再懸浮。估計適當細胞數及所需病毒-對於10 5個轉導細胞而言，需要100 μL所選效價之慢病毒。
在37℃水浴中將慢病毒等分試樣解凍。藉由置於4℃冰箱中來最小化病毒處於室溫下之時間量。將每一條件所需數量之T細胞轉移至無菌埃彭道夫管(Eppendorf tube)中(亦即5 × 105個T細胞)並旋轉(400 × g，5分鐘，RT)。棄除上清液，使用移液管去除過量培養基並皆以MOI 5 (例如100 μL/105個T細胞，亦即於500 μL慢病毒中之5 × 105個T細胞)再懸浮於慢病毒中。藉由使用完整TCM將原液(100mg/mL)稀釋25倍(以得到4mg/mL)來製備0.4 mg/mL聚凝胺。每100μL添加0.1μL 0.4 mg/mL聚凝胺(亦即，將0.5 μL添加至500 μL病毒中)。藉由使用完整TCM將原液(106 IU/mL)稀釋100倍來製備104 IU/mL IL-2。每100 μL添加2 μL 104 IU/mL IL-2 (亦即，將10uL添加至500uL病毒中)。將500 μL細胞適當再懸浮並使用病毒平鋪至平底48孔板之每一孔中。在32℃下以1200 × g將板旋轉1.5小時。8.在旋轉之後將細胞靜置5小時。在培育結束時，使用含有200 IU/mL IL-2之完整TCM加滿直至700 μL/孔。10.繼續培育72小時。 自培養物去除Dynabeads
將細胞充分地上下吸取(以剝離Dynabeads)並轉移至埃彭道夫管/FACS管中。確保有效進行此過程以最大程度地回收細胞。將管壓於小磁鐵(埃彭道夫管)/將其置於大磁鐵(FACS管)中並保持約3min。將細胞小心轉移 (埃彭道夫管)/倒出(FACS)於新falcon管中並以400 × g離心5分鐘。棄除上清液並再將細胞各懸浮於1.2 mL中。使用ViCELL-Blu 1對細胞進行計數。各獲取10 μL並再懸浮於190 μL PBS中(稀釋度：1:20)。
以1×10 6個細胞/ mL之濃度再懸浮細胞。添加200 IU/mL IL-2 (10 6IU/mL原液之1:5000稀釋液)。2. 在添加IL-2之前，獲取每一條件下之1×10 5個細胞以供轉導評價。細胞應保持於含有200 IU/mL IL-2之完整TCM中並穩定生長至少2週(供體可變性)。第二天及隨後，可將細胞染色以分析轉導效率，分選並擴增，或用於功能分析。 用於染色之細胞之製備
將NBC571、NBC572及NBC573 T細胞(模擬及轉導)染色。使用每一孔之1×10 5個細胞進行染色。將每一孔之1×10 5個細胞置於96孔圓底板中。使用抗酒精標記筆利用適當標識符來清楚地標記孔內容物。將IL-2 ( 200 IU/mL)添加至其餘細胞中且將細胞置於37℃、5% C02培育器中。 染色方案
使用PBS將孔加滿至200 μL且以500 × g將板旋轉3分鐘。藉由輕彈板來棄除上清液。藉由在PBS中以1:1000稀釋原液來製備固定活性染料efluorTM450。每一試樣需要100 μL活性染料製劑。向每一試樣中添加100 μL活性染色劑且將試樣在室溫下於暗處培育10分鐘。在培育期之後，使用100 μL BD染色緩衝液將孔加滿且以500 × g將板旋轉3分鐘。藉由輕彈來棄除上清液。藉由在BD染色緩衝液中以1 : 100稀釋原液來製備Fc封閉試劑之工作溶液。每一試樣需要100 μL Fc封閉溶液。10. 向每一試樣中添加100 μL Fc封閉溶液並在室溫下於暗處培育10分鐘。在培育期之後，使用100 μL染色緩衝液將孔加滿且以500 × g將板旋轉3分鐘。藉由輕彈來棄除上清液。13. 藉由在BD染色緩衝液中稀釋來製備CEA-Fc蛋白。將100 μL CEACAM5蛋白FC/BD混合至適當孔中。對於未接受CEACAM5蛋白-FC混合物之孔而言，僅添加100 μl BD染色緩衝液。將板在4℃下於暗處培育25分鐘(使用箔覆蓋板)。在培育期之後，使用100 μL BD染色緩衝液將孔加滿並以500 × g旋轉3分鐘。使用200 μL BD染色緩衝液將細胞洗滌2次。藉由在BD染色緩衝液中稀釋抗體來製備細胞外染色預混液及FMO對照。添加100 ul染色混合抗體及偶聯抗體。將板在4℃下於暗處培育25分鐘(使用箔覆蓋板)。在培育期之後，使用100 μL BD染色緩衝液將孔加滿並以500 × g旋轉3分鐘。藉由輕彈來棄除上清液。使用200 μL BD染色緩衝液將板洗滌2次。在第二洗滌之後，添加100 μL BD染色緩衝液。在NovoCyte上獲取信號。保存檔案並分析。 實例22 CD34 Miltenyi微珠富集
個別地處理每一供體。收集細胞且以400 × g將細胞懸浮液離心5分鐘。將細胞再懸浮於1mL完整TCM中並各將10 µL轉移至96孔U形底板中以供計數。添加190 µL PBS (以1:20稀釋試樣)。使用ViCELL-Blu對細胞進行計數。
向細胞中加入9 mL冷PEF並以400 × g離心5分鐘。完全吸出上清液。使用冷PEF緩衝液將細胞洗滌一次並各自再懸浮於最終體積為300 µL之冷PEF緩衝液中(模擬細胞並不計數，靜置於IL-2中直至REP)。 磁標記
添加用於最多總共10⁸個細胞之50 µL FcR封閉試劑。添加用於最多總共10⁸個細胞之50 µL CD34微珠。3. 充分混合混合物並在冰箱(2−8℃)中培育30分鐘。藉由添加5 mL緩衝液(用於最多10⁸個細胞)來洗滌細胞並以400×g離心5分鐘。完全吸出上清液。將最多10⁸個細胞再懸浮於500 µL冷PEF緩衝液中。 使用MS管柱之磁分離
將MS管柱置於OctoMACS分離器之磁場中。藉由使用500 µL冷PEF緩衝液沖洗來製備管柱。將細胞懸浮液施加於管柱上。收集含有未標記細胞之流經液。使用3×500 µL冷PEF緩衝液洗滌管柱。收集通過之未標記細胞並來自步驟3之流經液合併。僅在管柱儲槽變空時，藉由添加冷PEF緩衝液(4℃)等分試樣來實施洗滌步驟。自分離器取出管柱並置於適宜預標記收集管上。將1 mL冷PEF緩衝液移液於管柱上。立即藉由將柱塞用力推入管柱中來沖洗出磁標記細胞。(可選)為增加CD34+細胞之純度，可在第二MS或LS管柱上富集所洗脫級分。如上文所闡述藉由使用新管柱來重複磁分離程序。以400 × g離心5分鐘。完全吸出上清液。將陽性級分再懸浮於1 mL完整預熱TCM中。注意：在分選之前各獲取10 µL染色細胞，將100 µL陰性級分及20 µL陽性級分再懸浮於TCM中並在4℃下於BD染色緩衝液中使用CD34- PE (0.5 µL/100 µL反應液)珠粒將細胞染色15分鐘。在培育之後，使用100 µL BD染色緩衝液加滿且以500 × g將混合物離心3分鐘。將細胞再懸浮於100 µL含有DRAQ7之BD染色緩衝液中(1:200稀釋度)且在Novocyte 3005上各獲取120 µL以測定選擇效率。同樣，將20 µL之每一陽性級分轉移至96孔U形底板中以供計數。添加180 µL PBS (以1:10稀釋試樣)。使用ViCELL-Blu對細胞進行計數。 實例23 使用R+D方案設置之快速擴增方案(活化後D12) 材料及方法
使用ViCELL-Blu對靜置之模擬或CD34選擇細胞進行計數(10 μL每一試樣與190 μL PBS，1:20稀釋度)且以1e6個細胞/mL再懸浮細胞。使用經輻照飼養細胞。以1×10 8個細胞/ mL之濃度再懸浮細胞。以1×10 6/mL之密度將T細胞再懸浮於含有IL-2及OKT3細胞之完整REP TIL TCM培養基中，然後轉移至6孔G-REX孔中。將G-Rex板置於37℃ + 5% CO2之加濕培育器中。
每2-3天將IL-2添加至孔中。在第一天之後並不進一步添加OKT3。第2天REP (活化後15天)：向所有REP細胞中添加200 IU/mL IL-2。第4天REP (活化後17天)：向所有REP細胞中添加200 IU/mL IL-2。第6天REP (活化後19天)：在第6天，自每一孔去除培養基。對於6孔G-REX而言，自每一孔去除20 mL，注意不能破壞孔底之細胞並更換新鮮T細胞培養基。若培養基之顏色在第6天之前變為黃色，則提前更新培養基。在第6天之後，若培養基顏色變為黃色，則再次更新培養基且勿忘補充200 IU/mL IL-2。若培養基之pH不展示任何顏色變化，則培養基無需再次更換直至rep結束。第8天REP：自每一孔去除10 mL培養基且添加10 mL新鮮培養基以及IL-2 (200IU/mL)。第11天REP：添加IL-2 (200 IU/mL)。第14天REP (活化後第26天)：收集細胞並轉移至50 mL falcon管中。以400 × g將細胞離心5分鐘。將細胞再懸浮於50 mL TCM中。4. 使用ViCELL-Blu對細胞進行計數(10 μL試樣與190 μL PBS，1:20稀釋度)。將1 × 10 5個細胞染色以評價表型及轉導。將剩餘細胞冷凍以用於共培養。冷凍細胞以模擬先前過程。將細胞解凍並靜置，然後與呈現抗原之K562.luc.puro CEACAM5或K562.luc.puro MSLN細胞系一起共培養。 實例24 用於細胞介素分泌分析之細胞系共培養 材料及方法
對於共培養而言，為細胞系設置8:1之效應物對靶比率(E:T, 1×10個細胞: 1.25x10 4個細胞)。以1×10 6個細胞/ mL將T細胞再懸浮於完整TCM中且每孔使用100 μL。以1.25 ×105個細胞/ mL將靶細胞系再懸浮於完整TCM中且每孔使用100 μL。將單獨T細胞及單獨靶設定為陰性對照。將經PMA (50 ng / mL) /離子黴素( 1 μg / mL)刺激之T細胞設定為陽性對照。加入單獨T細胞，使用PMA/I刺激單獨靶及T細胞，每孔100 μL。每孔之最終體積為200 μL，且設置為一式三份。7. 將細胞在37℃下培育24小時。在培育後24小時，以400 × g將板旋轉5分鐘。收集上清液並將各80 μL等分試樣分佈至2 × 96孔U形底板中。在-80℃下冷凍上清液，各使用2份板等分試樣。 * * *
儘管已如此詳細地闡述本發明之較佳實施例，但應理解，由上述段落所界定之本發明並不限於上述說明中所陳述之特定細節，此乃因可對其實施多種明顯修改而不背離本發明之精神或範圍。
可聯合附圖來最佳地理解以實例方式給出但並不意欲將本發明僅限於所闡述具體實施例之下列詳細說明。
圖1 -單一共刺激及融合共刺激結構域受體之結構組織。展示申請專利範圍中所陳述之CoStAR受體之示意圖示。第一受體係基於單一共刺激受體之CoStAR，且第二受體係由融合至第二共刺激結構域之全長共刺激受體信號傳導結構域組成之融合CoStAR。
圖2 -潛在CoStAR構形之基因體組織- CoStAR由抗原結合結構域、可選間隔體結構域及共刺激結構域組成，如圖中所展示及申請專利範圍中所闡述。CoStAR可以以下方式進行表現：A)自啟動子單獨進行，其中CoStAR由單一(Ai)或融合(Aii)共刺激受體組成；B)可與N或C末端處之表位標籤(例如His標籤、DYKDDDDK (SEQ ID NO:449)等)一起表現以使得能夠將CoStAR直接染色；C)與使用2A裂解序列或內部核糖體進入位點(IRES)分隔之標記基因一起；D)與表現自第二啟動子之標記基因一起；E)與使用2A裂解序列或內部核糖體進入位點(IRES)分隔之所關注蛋白質(例如嵌合抗原受體或T細胞受體)一起；F)與表現自第二啟動子之所關注蛋白質(例如嵌合抗原受體或T細胞受體)一起。具有足夠知識者應明瞭，CoStAR及標記基因/嵌合抗原受體/T細胞受體/其他所關注蛋白質可彼此沿任一方向或沿3’ (3-prime)或5’ (5-prime)來表現。
圖3A-3E - T細胞中因應於LS174T及LoVo腫瘤呈現抗原之CoStAR之功能活性。對來自供體1 (3A &3 D)、供體2 (3B)及供體3 (3C & 3E)之正常供體T細胞群體進行慢病毒改造以表現靶向癌胚抗原之CoStAR，並使用CD34磁選擇進行磁分選以富集轉基因。將T細胞與野生型未改造CEA+腫瘤細胞(未活化腫瘤)或經改造以表現錨向細胞表面之抗CD3單鏈抗體片段之CEA+腫瘤細胞(活化腫瘤)以指示效應物對靶比率混合，並藉由ELISA量測上清液中之IL-2。使用LS174T細胞(3A, 3B & 3C)及LoVo (3D & 3E)獲得數據。
圖4A-4D - CoStAR對T細胞增殖之效應。將5×10 5個經轉導及未轉導T細胞與6.25×10 3或6.25×10 4個野生型LoVo或LoVo-OKT3細胞在存在(4A)或不存在(4B) IL-2下混合，並在三天之後對細胞進行計數。在另一分析中，在相同細胞比率下加載來自兩個供體(4C及4D)之T細胞與增殖染料，並在6天之後藉由染料稀釋使用流式細胞術來測定細胞已經歷之增殖週期數。
圖5 - CoStAR融合受體在原代人類T細胞中之IL-2活性。使用指示CEA靶向CoStAR慢病毒轉導來自7個供體(只是對照CoStAR係三個供體)之正常供體CD8+ T細胞，並於過夜刺激之後在LoVo-OKT3細胞存在下來評價IL-2產生。使用細胞內流式染色測定CD34陰性(CoStAR未轉導)及CD34+ (CoStAR轉導)群體中之IL-2陽性細胞之比例。星號展示使用配對魏可遜符號秩測試(paired Wilcoxon signed rank test)測得之轉導群體與未轉導群體之間之顯著差異，其中*p＜0.05。
圖6A-6D -原代人類T細胞中之CoStAR活性之多參數分析。使用指示CEA靶向CoStAR慢病毒轉導正常供體CD8+ T細胞，並於過夜刺激之後在LoVo-OKT3細胞存在下來評價IL-2產生。使用細胞內流式染色測定CD34陰性(CoStAR未轉導)及CD34+ (CoStAR轉導)群體中之IL-2 (7個供體) (圖6A)、IFNγ (7個供體) (圖6B)、BCL-xL (5個供體) (圖6C)及CD107a (6個供體) (圖6D)陽性細胞之比例。對照係非特異性CA125靶向CoStAR且在所有情況下皆來自三個供體。熱圖係所有供體之平均值，其中色彩強度與指定條件下特定讀出之陽性細胞之百分比相關。
圖7 - CD40增強了基於CD28之CoStAR之IL-2產生。來自三個健康供體之原代人類T細胞未經轉導或經細胞外結構域轉導之CD28 (Tr CD28)、全長CD28 (FL CD28)或含有CEA特異性scFv (MFE23)之基於CD28.CD40之CoStAR轉導。使用CD34標記基因選擇轉導細胞並在分析之前擴增。以8:1效應物對靶比率使T細胞與表現OKT3之CEA+ LoVo細胞混合20小時，然後藉由ELISA分析IL-2產生。
圖8 -信號傳導結構域及靶抗原對CoStAR介導之T細胞擴增之效應。使用加DYKDDDDK (SEQ ID NO:449)表位標籤之CD28或含有CA125、FolR或CEA特異性scFv或FolR特異性結合肽(C7)之基於CD28.CD40之CoStAR轉導T細胞。混合T細胞與表現OKT3之CA125+/FolR+/CEA-細胞系OVCAR3。每7天對轉導細胞之數量進行計數並持續21天，其中在每一計數後添加新鮮OVCAR3細胞。
圖9 -信號傳導結構域及靶抗原對CoStAR介導之T細胞擴增之效應。使用加DYKDDDDK (SEQ ID NO:449)表位標籤之CD28或含有CA125、FolR或CEA特異性scFv或FolR特異性結合肽(C7)之基於CD28.CD40之CoStAR轉導T細胞。混合T細胞與表現OKT3之CA125+/FolR+/CEA-細胞系OVCAR3。每7天對轉導細胞之數量進行計數並持續21天，其中在每一計數後添加新鮮OVCAR3細胞。
圖10A-10B - (10A及10B) 基於CD40之CoStAR增強了TCR轉移模型中之T細胞共刺激。使用CEA特異性TCR +加DYKDDDK標籤之CD28或含有MFE (空心或實心圓)或CA125 (空心正方形)特異性scFv之基於CD28.CD40之CoStAR來轉導來自三個健康供體之原代人類T細胞。以1:1效應物:靶比率混合T細胞與CEA+/CA125- H508細胞，並實施細胞內細胞介素染色以測定TCR+/CoStAR+、TCR+/CoStAR-、TCR-/CoStAR+及TCR-/CoStAR-群體中之具反應CD4+或CD8+ T細胞之數量。實施雙因子ANOVA (杜克測試(Tukeys test))以測定活性之顯著差異：*p＞0.05, ** p＞0.01, *** p＞0.001, **** p＞0.0001。
圖11繪示經轉導以表現共刺激分子之原代人類T細胞之富集及擴增。MFE23係對癌胚抗原(CEA)具有高親和力之單鏈Fv抗體。模擬轉導原代人類T細胞或使用MFE23.CD28或MFE23.CD28.CD40 CoStAR (各自具有由2A裂解肽分隔之CD34標記基因)進行轉導。在活體外培養後，使用MACS™順磁性選擇試劑(Miltenyi Biotech)針對CD34來富集細胞且然後使用經輻照飼養細胞擴增細胞數。展示來自三個供體中之一者之實例性繪圖。
圖12A-12D繪示經共刺激分子轉導之T細胞因應於刺激及外源性IL-2之擴增。模擬轉導細胞或使用MFE23.CD28或MFE23.CD28.CD40 CoStAR進行轉導並與LoVo-OKT3細胞以8:1效應物:靶比率在存在(200 IU/ml)或不存在外源性IL-2下一起共培養。在第1、4、7、11及18天，獲取細胞並藉由使用抗CD2試劑在MACSQuant流式細胞儀上來計算活T細胞之數量。(12A)在不存在腫瘤刺激及IL-2下，細胞數發生預期下降。(12B)在不存在刺激但存在IL-2下，細胞具有較明顯存活，但並無特異性生長。(12C)在存在腫瘤但不存在IL-2下，模擬細胞不展示特異性存活。MFE23.CD28 CoStAR在前4天中介導明顯之擴增倍增，隨後有所下降。MFE23.CD28.CD40介導較大擴增至第7天，隨後平穩下降。(12D)在相同條件下但在存在IL-2下，模擬及MFE23.CD28轉導細胞皆在18天顯示內20倍擴增，而MFE23.CD28.CD40細胞擴增60倍以上。因此，在刺激條件下於存在及不存在外源性IL-2下，基於CD28.CD40之受體皆顯示優良之擴增及存活。
圖13A-13M繪示經模擬、MFE23.CD28或MFE23.CD28.CD40改造之T細胞之細胞介素產生。對自T細胞/腫瘤共培養獲得之上清液實施珠粒陣列分析。將經改造T細胞與LoVo-OKT3細胞以1:1效應物:靶比率一起培育24小時並收集上清液。亦自相等數量之單獨T細胞或單獨LoVo-OKT3細胞收集條件化上清液。使用Legendplex™人類TH1/TH2細胞介素面板(Biolegend)分析細胞介素產生。(13A) IL-2；(13B) IFN-γ；(13C) TNFα；(13D) IL-4；(13E) IL-5；(13F) IL-13；(13G) IL-17A；(13H) IL-17F；(13I) IL-22；(13J) IL-6；(13K) IL-10；(13L) IL-9；(13M) IL-21。在僅T細胞或腫瘤之培養基中細胞介素極低或不可檢測。在與腫瘤一起共培養時，細胞介素產生有所增強。與模擬相比，MFE23.CD28增強了IL-2、IL-5、IL-17A/17F、IL-10、IL-9及IL-21之產生。MFE23.CD28.CD40亦增強了TNFα、IL-13及IL-22之產生。MFE23.CD28.CD40另外使許多細胞介素之產生增強至大於由MFE23.CD28提供者(IL-2、IL-9及IL-17F)且將一些細胞介素之產生降至低於使用MFE23.CD28所見之程度(IL-5及IL-10)。總而言之，此數據表明，將CD40添加至基於CD28之共刺激受體中增強及/或調節了其關於趨化介素產生之比活性。
圖14A-14M繪示使用Legendplex™人類促發炎性趨化介素面板之趨化介素分析。(14A) IL-8 (CXCL8)；(14B) IP-10 (CSCL10)；(14C)嗜酸性粒細胞趨化因子(Eotaxin) (CCL11)；(14D) TARC (CCL17)；(14E) MCP-1 (CCL2)；(14F) RANTES (CCL5)；(14G) MIP-1a (CCL3)；(14H) MIG (CXCL9)；(14I) ENA-78 (CXCL5)；(14J) MIP-3α (CCL20)；(14K) GROα (CXCL1)；(14L) I-TAC (CXCL11)；(14M) MEP-1β (CCL4)。在來自僅T細胞之培養基中，趨化介素極低或不可檢測。在與腫瘤一起共培養時，趨化介素產生有所增強。與模擬相比，MFE23.CD28增強了CXCL5、CXCL10、CXCL11、CCL17及CCL20之產生。MFE23.CD28.CD40亦增強了CCL2、CXCL1及CXCL9之產生。MFE23.CD28.CD40進一步將許多細胞介素之產生增強至大於由MFE23.CD28提供者(CXCL1、CXCL9、CXCL10、CXCL11、CCL17、CCL2、CXCL9、CCL5及CCL20)且將一些細胞介素之產生降至低於使用MFE23.CD28可見之程度(CCL4)。總而言之，此數據表明，將CD40添加至基於CD28之共刺激受體中增強及/或調節了其關於趨化介素產生之比活性。
圖15A-15H繪示使用含有FolR或CA125反應性scFv (分別為MOV19 & 196-14)之CoStAR獲得之卵巢CoStAR改造細胞之功能活性。人類葉酸鹽受體α (FolR)代表諸多腫瘤(包含卵巢、頭頸、腎及肺腫瘤)之適宜靶且CA125代表卵巢癌之替代靶。使用196-14.CD28、196-14.CD28.CD40、MOV19.CD28或MOV19.CD28.CD40受體(皆含有用於檢測之DYKDDDDK表位標籤)改造來自6個健康供體之原代人類T細胞。混合轉導細胞與FolR+/CA125+ OVCAR-OKT3細胞，然後使用細胞內染色分析表位標籤陽性及陰性群體中之效應活性。在因應於CA125及FolR之CD28及CD28.CD40改造細胞中觀察到效應活性(如根據IL-2 (15A及15B)、TNFα (15C及15D)、CD137 (15E及15F)及BCL-xL (15G及15H)之產生所測定)之特異性增強，只是與MOV19.CD28.CD40相比未觀察到MOV19.CD28之特異性BCL-xL誘導。
圖16A-16F繪示模擬轉導或經MOV19.CD28.CD40 CoStAR改造且然後與患者匹配之腫瘤消解物混合之三個TIL群體。供體腫瘤在消解時顯示自陰性(16A)、低表現(16B)至高表現(16C)之不同含量之FolR。與FolR陰性消解物匹配之CoStAR改造TIL群體中之模擬及CoStAR陰性TIL在腫瘤共培養後顯示類似程度之CD137上調，此並不因存在CoStAR而增強(16D)。在暴露於FolR低表現消解物之TIL中，與CoStAR-細胞相比CoStAR+細胞中之活性有所增強，其中CD137表現自＜10%增至＞20% (16E)。在暴露於高FolR腫瘤消解物之TIL中，CoStAR-群體中之活性增加約20%，在CoStAR+群體中最高增加大約50% (F)。
圖17A-17C繪示效應功能之增強。因應於FolR+腫瘤消解物，靶向FolR之CoStAR將CD137表現自約20%增強至約50% (17A)，將TNFα產生自10%增強至15% (17B)且將IL-2產生自2%增強至5% (17C)。
圖18A-18F繪示，可溶性配體不抑制效應功能。使用MOV19.CD28或MOV19.CD28.CD40 CoStAR改造來自三個健康供體之T細胞，並使用固定OKT3 (在不存在FolR下提供刺激)或使用OvCAR-OKT3活化以提供TCR及CoStAR活性。在OKT3刺激後，三個供體中之BCL-xL活性自10%增至20% (18A)，而IL-2自0%增至12% (18B)且TNFα自0%增至20% (18C)。外源性可溶性FolR之存在並不增強該等特定效應功能中之任一者。在OvCAR-OKT3存在下，CD28 CoStAR之BCL-XL誘導增強約20%但CD28.CD40 CoStAR之BCL-XL誘導增強約35% (18D)，CD28 CoStAR之IL-2誘導增強約20%但CD28.CD40 CoStAR之IL-2誘導增強30-50% (18E)，並且CD28 CoStAR之TNFα產生增強20-30%且CD28.CD40 CoStAR之TNFα產生增強25-50% (18F)。外源性可溶性FolR對該等效應功能中之任一者不具有抑制效應。
圖19繪示抗MSLN CoStAR在HD T細胞表面上之表面表現。對轉導及未轉導(模擬)細胞實施快速擴增方案(REP)，且經由分別使用抗CD34-APC (黑色)或抗MSLN-PE (紅色)抗體表面檢測標記基因tCD34 (截短CD34)或CoStAR分子來評價轉導效率。結果代表3個生物重複。
圖20A-20C繪示經抗MSLN CoStAR轉導並與OVCAR-3細胞系一起共培養之健康供體(HD) T細胞中之細胞介素表現。對包括6種不同抗MSLN scFv (SS1、M5、HN1、M912、huYP218、P4)及三種不同間隔體/跨膜結構域(CD28、N末端截短CD28、CD8)之組合之CoStAR進行比較。結構細節提供於表8、表9及表10中。展示與OVCAR-3或OVCAR3-OKT3細胞系共培養後(20A) IL-2、(20B) IFNγ及(20C) TNFα之細胞介素濃度。使用未處理T細胞作為對照。結果代表1-3個生物重複，其中每一生物重複具有3個技術重複。
圖21A-21C繪示經抗MSLN CoStAR轉導並與K562細胞系一起共培養之健康供體(HD) T細胞中之細胞介素表現。對包括6種不同抗MSLN scFv (SS1、M5、HN1、M912、huYP218、P4)及三種不同間隔體/跨膜結構域(CD28、N末端截短CD28、CD8)之組合之CoStAR進行比較。結構細節提供於表8、表9及表10中。展示與K562-MSNL或K562-MSNL-OKT3細胞系共培養後(21A) IL-2、(21B) IFNγ及(21C) TNFα之細胞介素濃度。使用未處理T細胞作為對照。結果代表1-3個生物重複，其中每一生物重複具有3個技術重複。
圖22繪示表現6種不同分泌信號肽(OSM1、CD8、CD2、IL2、GMCSF、hIgGκ)之MFE23 scFV抗CEA CoStAR之表面表現。結構細節提供於表11中。在擴增後，經由分別使用抗CD34-APC (黑條)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)表面檢測標記基因截短之CD34 (tCD34)或CoStAR分子來評價細胞之轉導效率。
圖23繪示包括6種不同抗CEA scFv (MFE23、MFE23(Q＞K)、hMFE23、CEA6、BW431/26、hT84.66)之CoStAR之表面表現。結構細節提供於表12中。在擴增後，經由分別使用抗CD34-APC (黑條)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)表面檢測標記基因截短之CD34 (tCD34)或CoStAR分子來評價細胞之轉導效率。
圖24A-24C繪示經抗CEA CoStAR (MFE23、MFE23(Q＞K)、hMFE23、CEA6、BW431/26、hT84.66)轉導並與LoVo細胞系一起共培養之健康供體(HD) T細胞之細胞介素產生。結構細節提供於表12中。展示在與Lovo或Lovo-OKT3細胞系一起共培養後(24A) IL-2、(24B) IFNγ及(24C) TNFα之細胞介素濃度。使用未處理T細胞作為陰性對照。
圖25A-25C繪示經抗CEA CoStAR (MFE23、MFE23(Q＞K)、hMFE23、CEA6、BW431/26、hT84.66)轉導並與K562細胞系一起共培養之健康供體(HD) T細胞中之細胞介素產生。展示在與K562.CEACAM5 (信號2)或K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養後(25A) IL-2、(25B) IFNγ及(25C) TNFα之細胞介素濃度。使用未處理T細胞作為陰性對照。
圖26繪示表現三種不同間隔體/跨膜結構域之hMFE23 scFV抗CEA CoStAR之表面表現。結構細節提供於表13中。在擴增後，經由使用抗CD34-APC (黑條)表面檢測標記基因截短之CD34 (tCD34)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰條)表面檢測CoStAR分子來評價細胞之轉導效率。
圖27A-27C繪示MFE23 scFV抗CEA間隔體變體之細胞介素產生。展示在與Lovo或Lovo.OKT3細胞系一起共培養後(27A) IL-2、(27B) IFNγ及(27C) TNFα之細胞介素濃度。使用未處理T細胞作為對照。
圖28繪示包括hMFE23 CEA結合結構域與細胞內信號傳導結構域(包括CD40、CD134、CD137、CD2、ICOS、DAP10及NTRK1信號傳導元件)之抗CEA CoStAR。
圖29繪示包括圖28中所繪示及表14中所詳述之結構域組合之hMFE23 scFV抗CEA CoStAR之表面表現。在擴增後，經由使用抗CD34-APC (黑圓)表面檢測標記基因截短之CD34 (tCD34)或使用含有二級抗IgG-Fc-PE抗體之一級rhCEACAM5-Fc抗體(灰圓)表面檢測CoStAR分子來評價細胞之轉導效率。結果代表三個生物重複。
圖30繪示三個單獨供體中之經CoStAR轉染之HD T細胞之T細胞表型。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在長出及REP後，使用流式細胞術評價1×10 5個細胞之分化亞型。Tcm，中央記憶性T細胞；Tem，效應記憶性T細胞；Tn，初始T細胞；Tscm，幹細胞記憶性T細胞；Tte，末端效應性T細胞。T細胞亞型定義可參見表15。
圖31A-31C繪示與K562細胞系一起共培養之經hMFE23 scFV抗CEA CoStAR轉導之HD T細胞之細胞介素產生。展示在與K562.CEACAM5 (信號2)或K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養後(31A) IL-2、(31B) IFNγ及(31C) TNFα之細胞介素濃度。使用未處理T細胞作為對照。
圖32A-32C繪示經hMFE23 scFV抗MSLN CoStAR轉導並與K562細胞系一起共培養之HD T細胞中之細胞介素表現。展示在與K562.CEACAM5 (信號2)或K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養後(32A) IL-2、(32B) IFNγ及(32C) TNFα表現細胞之頻率。使用未處理T細胞作為對照。
圖33繪示經hMFE23 scFV抗MSLN CoStAR轉導並與K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養之HD T細胞之增殖。自兩個供體獲得HD T細胞。各圖代表輸入細胞之倍數擴增。
圖34繪示經hMFE23 scFV抗MSLN CoStAR轉導並與K562.CEACAM5.OKT3 (信號1+2)細胞系一起共培養之HD T細胞之增殖。自兩個供體獲得HD T細胞。各圖代表在刺激後第6天輸入細胞之倍數擴增。
圖35A-35B繪示TRAF及TRAF樣結合位點及模體以及信號傳導路徑。35A. 展示TRAF結合位點及信號傳導之CoStAR CD40細胞內結構域。35B. 包括IProx結構域之CoStAR。
圖36A-36B繪示CoStAR CD40細胞內信號傳導結構域中之突變對與LoVo.OKT3一起共培養之經CD28.CD40 CoStAR轉導之T細胞之細胞介素分泌及長期存活與增殖的效應。使用Dynabeads活化三個供體之細胞並使用WT CD28.CD40 (CTP194)、含有TRAF2結合位點突變SVQE＞AVQA (CTP195)、TRAF2/TRAF3結合位點突變PVQET＞AVAEA (CTP196)、TRAF6結合位點突變PQEINF＞AQAINF (CTP197)、Q263A (CTP199)之CD28.CD40進行轉導，或實施模擬轉導。(36A) 量測在不存在IL-2下與LoVo或LoVo.OKT3.GFP腫瘤細胞共培養之後24小時收集之上清液中之IL-2。(36B)在6-8天之後評價生存力及絕對計數，且使用新鮮LoVo.OKT3.GFP腫瘤細胞將活T細胞再攻擊一週。在長期共培養結束時，量測生存力及絕對計數，且計算倍數擴增。數據展示為n≤3個供體之平均值+/- SEM，其中一式三份地進行分析。
圖37A-37B繪示解凍OC試樣在第1天基於CD2+染色之TIL百分比(37A)及總TIL計數(37B)。
圖38繪示非Td及Td TIL之生長。使用CD2及DRAQ7染色及Novocyte 3005上獲取對細胞進行計數。以圖形方式表示在第25天REP結束時之細胞計數。繪示對應於5份卵巢癌試樣中之每一者之形狀。實心形狀係非Td且空心形狀係Td TIL。使用配對t測試實施統計學分析。
圖39A-39D繪示經CoStAR修飾之TIL之轉導效率及每一細胞之病毒整合。在REP後第25天，評價未轉導(非Td)及經抗FOLR1 CoStAR轉導(Td)之TIL中CD3+ (39A)、CD4+ (39B)及CD8+ (39C)細胞群體之轉導效率。評價病毒拷貝數(VCN)以測定病毒整合(39D)。繪示對應於5份卵巢癌試樣中之每一者之形狀。實心形狀係非Td且空心形狀係Td TIL。
圖40繪示REP後TIL中之CD4及CD8群體。在REP後D25使用流式細胞術評價未轉導(非Td)及經抗FOLR1 CoStAR轉導(Td)以及抗FOLR1 CoStAR+ Td之TIL之CD4及CD8組成。使用二因子ANOVA與匹配杜克多重對比事後測試實施統計學分析。
圖41A-41C繪示CoStAR修飾對TIL之分化狀態之效應。在REP後D25評價未轉導(非Td) TIL、經抗FOLR1 CoStAR轉導(Td)之TIL及抗FOLR1 CoStAR+ Td TIL中總T細胞(41A)、CD4+ (41B)及CD8+ (41C)細胞群體之分化狀態。使用二因子ANOVA與匹配杜克多重對比測試實施統計學分析。觀察抗FORL1 CoStAR- Td TIL與抗FOLR1 CoStAR+ Td TIL之間CD3+ (A)及CD4+ (B)群體中之Tscm群體之統計學顯著性。*p＜0.05。
圖42A-42B繪示TIL之CoStAR修飾對共抑制或共刺激標記物表現之效應。評價未轉導(非Td) TIL、經抗FOLR1 CoStAR轉導(Td)之TIL及抗FOLR1 CoStAR+ Td TIL中CD4+ (42A)及CD8+ (42B)細胞群體中之共抑制及共刺激標記物之表現。繪示對應於5份卵巢癌試樣中之每一者之形狀，不考慮是否填充。黑條、深灰條及淺灰條分別代表非Td TIL、抗FOLR1 CoStAR- Td TIL及抗FOLR1 CoStAR+ Td TIL。使用二因子ANOVA與匹配杜克多重對比事後測試實施統計學分析。*p＜0.05。
圖43A-43B繪示CoStAR修飾對TIL中之TCRαβ、TCRγδ及Treg頻率之效應。評價未轉導(非Td) TIL、經抗FOLR1 CoStAR轉導(Td)之TIL及抗FOLR1 CoStAR+ Td TIL中CD3+細胞群體(43A)中之TCRαβ (CD3+TCRαβ+)及TCRγδ (CD3+TCRγδ+)之頻率。亦評價CD4+亞群體中之Treg之頻率(43B)。繪示對應於5份卵巢癌試樣中之每一者之形狀，不考慮是否填充。黑條、深灰條及淺灰條分別代表非Td TIL、抗FOLR1 CoStAR- Td TIL及抗FOLR1 CoStAR+ Td TIL。使用二因子ANOVA與匹配杜克多重對比事後測試(43A)及單因子ANOVA與弗裡德曼事後測試(Friedman’s post-test) (43B)實施統計學分析。
圖44A-44C繪示TIL之CoStAR修飾對促有絲分裂活化時之細胞介素產生之效應。評價在使用PMA (50 ng/mL) /離子黴素(1 μg/mL)刺激4小時時未轉導(非Td) TIL、經抗FOLR1 CoStAR轉導(Td) TIL及抗FOLR1 CoStAR+ Td TIL中CD3+ (44A)、CD4+ (44B)及CD8+ (44C)細胞群體中之細胞介素產生。繪示對應於5份OC試樣中之每一者之形狀，不考慮是否填充。黑條、深灰條及淺灰條分別代表非Td TIL、抗FOLR1 CoStAR- Td TIL及抗FOLR1 CoStAR+ Td TIL。使用二因子ANOVA與匹配杜克多重對比事後測試實施統計學分析。* p≤0.05, *** p≤0.001。
圖45繪示OC消解細胞上之FOLR1表現。將冷凍保存之自體腫瘤消解物解凍並藉由流式細胞術分析以測定每一供體之FOLR1之表面表現。展示用於研究中之所有5個供體。縮寫：OC，卵巢癌；FOLR1，葉酸鹽受體α；FOLR1 PE，偶聯至PE之抗FOLR1抗體；PE，藻紅素。
圖46A-46D繪示CoStAR修飾對在與自體腫瘤一起共培養時之細胞介素產生細胞之效應。將非Td及抗FOLR1 CoStAR Td TIL與自體腫瘤消解物一起共培養16小時，且實施細胞內流式細胞術以評估產生細胞介素之細胞之比例。評價IL-2陽性(46A) CD4及(46B) CD8 TIL之頻率以及TNFα陽性(46C) CD4及(46D) CD8 TIL之頻率。結果代表5個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與杜克多重對比測試實施統計學分析。*P ＜0.05。
圖47A-47E繪示CoStAR修飾對在與表現FOLR1之自體腫瘤消解物一起共培養時之細胞介素分泌之效應。將非Td及經抗FOLR1 CoStAR轉導(Td)之TIL與自體腫瘤消解物一起共培養24小時，隨後收集上清液並使用MSD免疫分析來分析細胞介素分泌。各圖形代表共培養上清液中之(47A) IL-2、(47B) TNFα、(47C) IL-13及(47D) IFNγ之量測濃度。(47E) IFNγ濃度與如圖1中所測得自體消解物之FOLR1表現之間之相關性。結果代表5個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與斯大克多重對比測試(Sidak’s multiple comparisons test)實施統計學分析。使用簡單線性回歸實施相關性分析。*P ＜0.05, **P ＜0.01, ***P＜0.001。
圖48繪示在與自體腫瘤消解物共培養時之MHC依賴性CoStAR功能性之評價。將非Td及經抗FOLR1 CoStAR轉導(Td)之TIL與自體腫瘤消解物在MHC封閉試劑或同型對照存在下一起共培養24小時。然後使用MSD免疫分析分析上清液之IFNγ細胞介素產生。結果代表3個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與杜克多重對比測試實施統計學分析。
圖49A-49B繪示CoStAR修飾對在與經改造細胞系一起共培養時之細胞介素產生細胞頻率之效應。將非Td及經抗FORL1 CoStAR轉導之(Td) TIL與經改造靶細胞系一起共培養16小時，且使用細胞內流式細胞術量測細胞介素產生細胞。展示在與K-562 (左圖)及OVCAR-3 (右圖)源細胞系一起共培養後CD4+ (上圖)及CD8+ (下圖) TIL中之IL-2陽性(49A)之頻率。展示在與K-562 (左圖)及OVCAR-3 (右圖)源細胞系一起共培養後CD4+ (上圖)及CD8+ (下圖) TIL中之TNFα陽性(49B)之頻率。結果代表5個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與杜克多重對比測試實施統計學分析。*P ＜0.05, **P ＜0.01, ***P ＜0.001, ****P ＜0.0001。
圖50A-50D繪示CoStAR修飾對在與經改造細胞系一起共培養時之細胞介素分泌之效應。將非Td及經抗FOLR1 CoStAR轉導(Td)之TIL與經改造靶細胞系一起共培養24小時，且實施MSD免疫分析以評估所分泌細胞介素之濃度。展示在與(左圖) K-562及(右圖) BA/F3源細胞系一起共培養後(50A) IL-2、(50B) TNFα、(50C) IL-13及(50D) IFNγ之細胞介素濃度。結果代表5個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與杜克多重對比測試實施統計學分析。*P ＜0.05, **P ＜0.01, ***P ＜0.001, ****P ＜0.0001。
圖51A-51C繪示CoStAR修飾對TIL針對具OKT3靶之細胞毒性能力之影響之評價。將非Td及經抗FOLR1 CoStAR轉導(Td)之TIL與BA/F3或OVCAR-3經改造細胞系一起共培養，且分別使用基於流式細胞術之分析(51A)及基於xCELLigence之分析(51B及51C)評價細胞毒性。(51B) 1:5之E:T比率及(51C) 1:30之E:T比率。結果代表5個生物重複，其中每一生物重複具有3個技術重複。使用二因子ANOVA與杜克多重對比測試對流式細胞術數據實施統計學分析，且使用單因子ANOVA與杜克多重對比測試對xCELLigence數據實施統計學分析。*P ＜0.05, **P ＜0.01。
圖52A-52D繪示具有＞80%生存力及約100-200百萬個細胞、40-55% CD3+ T細胞CoStAR轉導及＞90% CD3+ T細胞純度之NSCLC TIL之擴增。
圖53繪示具有＞80%生存力之NSCLC TIL之擴增。CoStAR轉導及未轉導群體在生存力及細胞擴增方面並無差異。
圖54繪示在收穫時具有50-500百萬個細胞之NSCLC TIL之擴增。CoStAR轉導及未轉導群體在生存力及細胞擴增方面並無差異。
圖55繪示7份患者試樣之T細胞群體。
圖56繪示CD3與CD56，其中將CD3+標記為T細胞且將CD3-CD56+標記為NK細胞。
圖57繪示未轉導及經CoStAR轉導之T細胞之量化。
圖58繪示T細胞子組中之CoStAR染色。
圖59A-59D繪示卵巢癌TIL在REP期間之生存力之顯著增加，其中該等TIL在製造製程結束時具有＞90%之生存力且在收穫時具有100-300百萬個細胞。
圖60A-60D繪示在長出期間始終顯示＞50%之生存力、在製造製程結束時具有＞90%之生存力且在收穫時具有100-350百萬個細胞之腎癌TIL。
圖61A-61B繪示根據標準方案使用抗間皮素抗體(純系5B2)與Dako自動染色儀Link 48所實施之IHC。藉由5B2結合陽性細胞%之病理學家詮釋來評估評分。H評分計算為5B2結合陽性細胞%乘以以下病理學家估計值：0 (無染色)、1 (弱染色)、2 (中等染色)或3 (強染色)。
圖62繪示在構築體中包括不同scFV結構域但保留所有其他結構域之scFV抗MSNL CoStAR之表面表現。在轉導後第4天經由使用抗CD34-APC (黑條)表面檢測標記基因截短之CD34 (tCD34)或使用一級MSNL-PE抗體(灰條)表面檢測CoStAR分子來評價細胞之轉導效率。結果代表一個生物重複。
圖63A-63B繪示在構築體中包括不同scFV結構域但保留所有其他結構域之scFV抗MSNL CoStAR之表面表現之點圖。在轉導後第4天經由使用抗CD34-APC (y軸)表面檢測標記基因截短之CD34 (tCD34)或使用一級MSNL-PE抗體(x軸)表面檢測CoStAR分子來評價細胞之轉導效率。
圖64繪示在構築體中包括不同scFV結構域但保留所有其他結構域之scFV抗MSNL CoStAR之表面表現。在轉導後第4天經由使用抗CD34-APC (黑條、黑圓)表面檢測標記基因截短之CD34 (tCD34)或使用一級MSNL-PE抗體(灰條、灰圓)表面檢測CoStAR分子來評價細胞之轉導效率。每一圖形代表CD3、CD4及CD8中之群體轉導效率。結果代表一個生物重複。
圖65繪示在構築體中包括不同scFV結構域但保留所有其他結構域之scFV抗MSNL CoStAR之表面表現。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，抗CD34-APC (黑條、黑圓)，或CoStAR分子使用一級MSNL-PE抗體(灰條、紅圓)。每一圖形代表CD3、CD4及CD8中之群體轉導效率。結果代表一個生物重複。
圖66繪示在構築體中包括不同scFV結構域但保留所有其他結構域之scFV抗MSNL CoStAR之表面表現。使用CD34微珠分選細胞並實施快速擴增方案(REP) 14天。在擴增後，抗CD34-APC (黑圓)，或CoStAR分子使用一級MSNL-PE抗體(紅圓)。每一圖形代表CD3細胞群體中之轉導效率。結果代表3個生物重複。
圖67繪示一種實驗計劃，其中使用用於6種MSLN靶向CoStAR中之1者之慢病毒轉導供體PBMC。使轉導細胞長出，隨後實施CD34選擇及12天REP，且隨後與表現MSLN及OKT3之天然Ovcar3細胞系一起共培養，其中藉由CoStAR表現細胞來評估細胞介素釋放。
圖68繪示使用流式細胞術檢測OVCAR-3及OVCAR-3-OKT3之圈選策略及MSNL檢測。使用抗MSNL APC抗體將細胞染色。
圖69A-69B繪示經scFV抗MSLN CoStAR轉導並與K562細胞系一起共培養之HD T細胞中之細胞介素表現。所評價構築體之scFV及間隔體結構域有所不同，如下文所展示。展示與OVCAR-3 (信號2)或OVCAR-3-OKT3 (信號1+2)細胞系一起共培養後IL-2、IFNγ及TNFα表現細胞之頻率。使用未處理T細胞作為對照。結果代表3個生物重複。
圖70A-70B繪示經scFV抗MSLN CoStAR轉導並與K562細胞系一起共培養之HD T細胞中之細胞介素表現。所評價構築體之scFV及間隔體結構域有所不同，如上文所展示。展示與K562.MSNL (信號2)或K562.MSNL.OKT3 (信號1+2)細胞系一起共培養後(A) IL-2、(B) IFNγ及(C) TNFα表現細胞之頻率。使用未處理T細胞作為對照。結果代表3個生物重複。
圖71繪示兩種CoStAR構築體在製造結束時未修飾及經抗CEA CoStAR修飾之TIL之倍數擴增。
圖72繪示使用兩種抗CEA CoStAR構築體在製造結束時(第21天)之TIL轉導效率。
圖73繪示使用兩種抗CEA CoStAR構築體自CRC、NSCLC、卵巢腫瘤及黑色素瘤生成之TIL在製造結束時(第21天)之轉導效率。
圖74繪示自CRC、NSCLC、卵巢腫瘤及黑色素瘤生成並經兩種抗CEA CoStAR構築體轉導之TIL在製造結束時(第21天)之記憶表型。
圖75繪示自CRC腫瘤衍生、經兩種抗CEA CoStAR構築體轉導並與靶細胞K562、K652-OKT3、K562-CEACAM5、K562-OKT3-CEACAM5一起培育之TIL或單獨T細胞中之細胞介素表現。
圖76繪示自NSCLC腫瘤衍生、經兩種抗CEA CoStAR構築體轉導並與靶細胞K562、K652-OKT3、K562-CEACAM5、K562-OKT3-CEACAM5一起培育之TIL或單獨T細胞中之細胞介素表現。
圖77繪示自OV-9662細胞及黑色素瘤衍生、經兩種抗CEA CoStAR構築體轉導並與靶細胞K562、K652-OKT3、K562-CEACAM5、K562-OKT3-CEACAM5一起培育之TIL或單獨T細胞中之細胞介素表現。
圖78繪示自黑色素瘤細胞衍生、經兩種抗CEA CoStAR構築體轉導並與靶細胞K562、K652-OKT3、K562-CEACAM5、K562-OKT3-CEACAM5一起培育之TIL或單獨T細胞中之細胞介素表現。
圖79繪示經2種抗CEA CoStAR構築體中之1者轉導且隨後與K562-OKT3-CEACAM5細胞一起培育之CRC11959細胞中之倍數擴增及轉導效率。在1-4或1-6週評估倍數擴增。在0-21或0-28天評估轉導效率。
圖80繪示經2種抗CEA CoStAR構築體中之1者轉導且隨後與K562-OKT3-CEACAM5細胞一起培育之NSCLC 9332細胞中之倍數擴增及轉導效率。在1-6週評估倍數擴增。在0-28天評估轉導效率。
圖81繪示經2種抗CEA CoStAR構築體中之1者轉導且隨後與K562-OKT3-CEACAM5細胞一起培育之OV 9662細胞中之倍數擴增及轉導效率。在1-4週評估倍數擴增。在0-21天評估轉導效率。
圖82繪示經2種抗CEA CoStAR構築體中之1者轉導且隨後與K562-OKT3-CEACAM5細胞一起培育之Mel CC50、Mel 11909及Mel 17614細胞中之倍數擴增及轉導效率。在1-4週評估倍數擴增。在0-21天評估轉導效率。
圖83繪示構成CEA.ICOS.CD40 CoStAR之胺基酸序列。
圖84A-84C繪示構成靶向MSLN之CoStAR CTP224-CTP229之胺基酸序列以及SS1、M5、HN1、M912、huYP218及P4之靶向MSLN之scFv序列。
 

          <![CDATA[<110> 英商英斯特生物科技有限公司(INSTIL BIO (UK) LIMITED)]]>
                美商英斯特生物科技股份有限公司(INSTIL BIO, INC.)
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          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 6]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg
                      20  
          <![CDATA[<210> 7]]>
          <![CDATA[<211> 25]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 7]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met
                      20                  25  
          <![CDATA[<210> 8]]>
          <![CDATA[<211> 23]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 8]]>
          Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
           1               5                  10                  15      
          Leu Gly Trp Arg Pro Gly Trp
                      20              
          <![CDATA[<210> 9]]>
          <![CDATA[<211> 244]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 9]]>
          Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
                      20                  25                  30          
          Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
                  35                  40                  45              
          Gly Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Asn Phe
              50                  55                  60                  
          Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His
          65                  70                  75                  80  
          Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Thr Arg Tyr Asp Gly Ser Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr
                      100                 105                 110         
          Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
                  115                 120                 125             
          Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu
              130                 135                 140                 
          Ala Val Ser Leu Gly Gln Arg Ala Ile Ile Ser Cys Lys Ala Ser Gln
          145                 150                 155                 160 
          Ser Val Ser Phe Ala Gly Thr Ser Leu Met His Trp Tyr His Gln Lys
                          165                 170                 175     
          Pro Gly Gln Gln Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu
                      180                 185                 190         
          Ala Gly Val Pro Thr Arg Phe Ser Gly Ser Gly Ser Lys Thr Asp Phe
                  195                 200                 205             
          Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr
              210                 215                 220                 
          Cys Gln Gln Ser Arg Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys
          225                 230                 235                 240 
          Leu Glu Ile Lys
          <![CDATA[<210> 10]]>
          <![CDATA[<211> 242]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 10]]>
          Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr
           1               5                  10                  15      
          Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser
                      20                  25                  30          
          Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile
                  35                  40                  45              
          Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe
              50                  55                  60                  
          Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr
          65                  70                  75                  80  
          Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln
                      100                 105                 110         
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ala
              130                 135                 140                 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala
          145                 150                 155                 160 
          Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr
                          165                 170                 175     
          Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val
                      180                 185                 190         
          Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
                  195                 200                 205             
          Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
          225                 230                 235                 240 
          Lys Arg
          <![CDATA[<210> 11]]>
          <![CDATA[<211> 242]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 11]]>
          Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr
           1               5                  10                  15      
          Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser
                      20                  25                  30          
          Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile
                  35                  40                  45              
          Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe
              50                  55                  60                  
          Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr
          65                  70                  75                  80  
          Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln
                      100                 105                 110         
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ala
              130                 135                 140                 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala
          145                 150                 155                 160 
          Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr
                          165                 170                 175     
          Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val
                      180                 185                 190         
          Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
                  195                 200                 205             
          Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
          225                 230                 235                 240 
          Lys Arg
          <![CDATA[<210> 12]]>
          <![CDATA[<211> 241]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 12]]>
          Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser
                      20                  25                  30          
          Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp Ile
                  35                  40                  45              
          Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe
              50                  55                  60                  
          Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr
          65                  70                  75                  80  
          Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln
                      100                 105                 110         
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
                  115                 120                 125             
          Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro Ser
              130                 135                 140                 
          Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile Ala Cys Ser Ala
          145                 150                 155                 160 
          Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Lys
                          165                 170                 175     
          Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val
                      180                 185                 190         
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr
                  195                 200                 205             
          Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
          225                 230                 235                 240 
          Lys
          <![CDATA[<210> 13]]>
          <![CDATA[<211> 246]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 13]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
           1               5                  10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Ser
                      20                  25                  30          
          Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
                  35                  40                  45              
          Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
              50                  55                  60                  
          Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
          65                  70                  75                  80  
          Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr Tyr Met Asp Val
                      100                 105                 110         
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
                  115                 120                 125             
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
              130                 135                 140                 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
          145                 150                 155                 160 
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                          165                 170                 175     
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                      180                 185                 190         
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  195                 200                 205             
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
              210                 215                 220                 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
          225                 230                 235                 240 
          Lys Leu Glu Ile Lys Arg
                          245     
          <![CDATA[<210> 14]]>
          <![CDATA[<211> 243]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 14]]>
          Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu
           1               5                  10                  15      
          Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr Ser
                      20                  25                  30          
          Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly
                  35                  40                  45              
          Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys Ser
              50                  55                  60                  
          Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Arg
          65                  70                  75                  80  
          Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg
                          85                  90                  95      
          Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly Ser
                      100                 105                 110         
          Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
                  115                 120                 125             
          Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln Met Thr Gln Ser
              130                 135                 140                 
          Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
          145                 150                 155                 160 
          Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro
                          165                 170                 175     
          Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser
                      180                 185                 190         
          Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                  195                 200                 205             
          Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys
              210                 215                 220                 
          His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
          225                 230                 235                 240 
          Ile Lys Arg
          <![CDATA[<210> 15]]>
          <![CDATA[<211> 247]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213>]]> 人工序列
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 15]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
           1               5                  10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
                      20                  25                  30          
          Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                  35                  40                  45              
          Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Ala Asp Ser Val
              50                  55                  60                  
          Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
          65                  70                  75                  80  
          Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp Gly
                      100                 105                 110         
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
                  115                 120                 125             
          Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro
              130                 135                 140                 
          Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg
          145                 150                 155                 160 
          Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp Tyr
                          165                 170                 175     
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser
                      180                 185                 190         
          Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg
                  195                 200                 205             
          Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala
              210                 215                 220                 
          Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly Gln
          225                 230                 235                 240 
          Gly Thr Lys Val Glu Ile Lys
                          245         
          <![CDATA[<210> 16]]>
          <![CDATA[<211> 136]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 16]]>
          Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro
           1               5                  10                  15      
          Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr
                      20                  25                  30          
          Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp
                  35                  40                  45              
          Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro
              50                  55                  60                  
          Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln
          65                  70                  75                  80  
          Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg
                          85                  90                  95      
          Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys
                      100                 105                 110         
          Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg
                  115                 120                 125             
          Arg Ala Glu Val Pro Thr Ala His
              130                 135     
          <![CDATA[<210> 17]]>
          <![CDATA[<211> 120]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 17]]>
          Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys
           1               5                  10                  15      
          Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln
                      20                  25                  30          
          Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys
                  35                  40                  45              
          Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val
              50                  55                  60                  
          Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn
          65                  70                  75                  80  
          Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr
                          85                  90                  95      
          Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu
                      100                 105                 110         
          His Gly Ala Arg Phe Gln Ile Pro
                  115                 120 
          <![CDATA[<210> 18]]>
          <![CDATA[<211> 9]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 18]]>
          Ala Ala Ala Gly Ser Gly Gly Ser Gly
           1               5                  
          <![CDATA[<210> 19]]>
          <![CDATA[<211> 159]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 19]]>
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
           1               5                  10                  15      
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
                      20                  25                  30          
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
                  35                  40                  45              
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
              50                  55                  60                  
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
          65                  70                  75                  80  
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                          85                  90                  95      
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
                      100                 105                 110         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  115                 120                 125             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              130                 135                 140                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          145                 150                 155                 
          <![CDATA[<210> 20]]>
          <![CDATA[<211> 83]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 20]]>
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
           1               5                  10                  15      
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
                      20                  25                  30          
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
                  35                  40                  45              
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
              50                  55                  60                  
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
          65                  70                  75                  80  
          His Arg Asn
          <![CDATA[<210> 21]]>
          <![CDATA[<211> 27]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 21]]>
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
           1               5                  10                  15      
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                      20                  25          
          <![CDATA[<210> 22]]>
          <![CDATA[<211> 39]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 22]]>
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
           1               5                  10                  15      
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                      20                  25                  30          
          Ala Phe Ile Ile Phe Trp Val
                  35                  
          <![CDATA[<210> 23]]>
          <![CDATA[<211> 48]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 23]]>
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
           1               5                  10                  15      
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                      20                  25                  30          
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                  35                  40                  45              
          <![CDATA[<210> 24]]>
          <![CDATA[<211> 257]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 24]]>
          Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
           1               5                  10                  15      
          Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                      20                  25                  30          
          Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
                  35                  40                  45              
          Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
              50                  55                  60                  
          Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
          65                  70                  75                  80  
          Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                          85                  90                  95      
          Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
                      100                 105                 110         
          Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
                  115                 120                 125             
          Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
              130                 135                 140                 
          Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
          145                 150                 155                 160 
          Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                          165                 170                 175     
          Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
                      180                 185                 190         
          Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
                  195                 200                 205             
          Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
              210                 215                 220                 
          Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val
          225                 230                 235                 240 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                          245                 250                 255     
          Val
          <![CDATA[<210> 25]]>
          <![CDATA[<211> 41]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 25]]>
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
           1               5                  10                  15      
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      20                  25                  30          
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                  35                  40      
          <![CDATA[<210> 26]]>
          <![CDATA[<211> 46]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 26]]>
          Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
           1               5                  10                  15      
          Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
                      20                  25                  30          
          Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
                  35                  40                  45      
          <![CDATA[<210> 27]]>
          <![CDATA[<211> 37]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 27]]>
          Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly
           1               5                  10                  15      
          Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser
                      20                  25                  30          
          Thr Leu Ala Lys Ile
                  35          
          <![CDATA[<210> 28]]>
          <![CDATA[<211> 116]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 28]]>
          Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr
           1               5                  10                  15      
          Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln
                      20                  25                  30          
          Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro
                  35                  40                  45              
          Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro
              50                  55                  60                  
          Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro
          65                  70                  75                  80  
          Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro
                          85                  90                  95      
          Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser
                      100                 105                 110         
          Pro Ser Ser Asn
                  115     
          <![CDATA[<210> 29]]>
          <![CDATA[<211> 58]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 29]]>
          Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro
           1               5                  10                  15      
          Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala
                      20                  25                  30          
          Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu
                  35                  40                  45              
          Glu Lys Gly Arg Leu Gly Asp Leu Trp Val
              50                  55              
          <![CDATA[<210> 30]]>
          <![CDATA[<211> 47]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 30]]>
          Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu
           1               5                  10                  15      
          Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr
                      20                  25                  30          
          Lys Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys
                  35                  40                  45          
          <![CDATA[<210> 31]]>
          <![CDATA[<211> 75]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 31]]>
          Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val Glu Lys Lys
           1               5                  10                  15      
          Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro Leu Gln Lys
                      20                  25                  30          
          Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr Ile Tyr Val
                  35                  40                  45              
          Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr Asn Ser Ile
              50                  55                  60                  
          Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser
          65                  70                  75  
          <![CDATA[<210> 32]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 32]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 33]]>
          <![CDATA[<211> 125]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 33]]>
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
           1               5                  10                  15      
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      20                  25                  30          
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  35                  40                  45              
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Lys Val Ala Lys
              50                  55                  60                  
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
          65                  70                  75                  80  
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                          85                  90                  95      
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                      100                 105                 110         
          Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Lys Val Ala
                  115                 120                 125 
          <![CDATA[<210> 34]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 34]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Ala His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 35]]>
          <![CDATA[<211> 8]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人]]>工序列
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 35]]>
          Lys Pro Thr Asn Lys Ala Pro His
           1               5              
          <![CDATA[<210> 36]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 36]]>
          Pro Lys Gln Glu
           1              
          <![CDATA[<210> 37]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223>]]> 合成多肽
          <![CDATA[<400> 37]]>
          Pro Val Gln Glu
           1              
          <![CDATA[<210> 38]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 38]]>
          Ser Val Gln Glu
           1              
          <![CDATA[<210> 39]]>
          <![CDATA[<211> 9]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 39]]>
          Gln Glu Pro Gln Glu Ile Asn Phe Pro
           1               5                  
          <![CDATA[<210> 40]]>
          <![CDATA[<211> 7]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 40]]>
          Lys Lys Pro Thr Asn Lys Ala
           1               5          
          <![CDATA[<210> 41]]>
          <![CDATA[<211> 7]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 41]]>
          Ser Arg Ile Ser Val Gln Glu
           1               5          
          <![CDATA[<210> 42]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 42]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 43]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 43]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
                  275                 280                 285             
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
              290                 295                 300                 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
          305                 310                 315                 320 
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                          325                 330                 335     
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                      340                 345                 350         
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                  355                 360                 365             
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
              370                 375                 380                 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
          385                 390                 395                 400 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                          405                 410                 415     
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                      420                 425                 430         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  435                 440                 445             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              450                 455                 460                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 44]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 44]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 45]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 45]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 46]]>
          <![CDATA[<211> 530]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 46]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys
                      260                 265                 270         
          Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys
                  275                 280                 285             
          Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His
              290                 295                 300                 
          Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr
          305                 310                 315                 320 
          Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly
                          325                 330                 335     
          Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val
                      340                 345                 350         
          Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro
                  355                 360                 365             
          Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys
              370                 375                 380                 
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
          385                 390                 395                 400 
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                          405                 410                 415     
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                      420                 425                 430         
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                  435                 440                 445             
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
              450                 455                 460                 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
          465                 470                 475                 480 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                          485                 490                 495     
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                      500                 505                 510         
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                  515                 520                 525             
          Arg Gln
              530 
          <![CDATA[<210> 47]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 47]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 48]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 48]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 49]]>
          <![CDATA[<211> 458]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 49]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
                  275                 280                 285             
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
              290                 295                 300                 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
          305                 310                 315                 320 
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                          325                 330                 335     
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                      340                 345                 350         
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  355                 360                 365             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              370                 375                 380                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455             
          <![CDATA[<210> 50]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 50]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 51]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 51]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 52]]>
          <![CDATA[<211> 454]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 52]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val
                      260                 265                 270         
          Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr
                  275                 280                 285             
          Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala
              290                 295                 300                 
          Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe
          305                 310                 315                 320 
          Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val
                          325                 330                 335     
          Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg
                      340                 345                 350         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  355                 360                 365             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              370                 375                 380                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          385                 390                 395                 400 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          405                 410                 415     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      420                 425                 430         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  435                 440                 445             
          Ser Val Gln Glu Arg Gln
              450                 
          <![CDATA[<210> 53]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 53]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 54]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 5]]>4
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 55]]>
          <![CDATA[<211> 402]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 55]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                  275                 280                 285             
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
              290                 295                 300                 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
          305                 310                 315                 320 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                          325                 330                 335     
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      340                 345                 350         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  355                 360                 365             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              370                 375                 380                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          385                 390                 395                 400 
          Arg Gln
          <![CDATA[<210> 56]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 56]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 57]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 57]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 58]]>
          <![CDATA[<211> 398]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 58]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu
                      260                 265                 270         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  275                 280                 285             
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
              290                 295                 300                 
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
          305                 310                 315                 320 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                          325                 330                 335     
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                      340                 345                 350         
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                  355                 360                 365             
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
              370                 375                 380                 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395             
          <![CDATA[<210> 59]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 59]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 60]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 60]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 61]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 61]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
                  275                 280                 285             
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
              290                 295                 300                 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
          305                 310                 315                 320 
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                          325                 330                 335     
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                      340                 345                 350         
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                  355                 360                 365             
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
              370                 375                 380                 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
          385                 390                 395                 400 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                          405                 410                 415     
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                      420                 425                 430         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  435                 440                 445             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              450                 455                 460                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 62]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 62]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 63]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 63]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 64]]>
          <![CDATA[<211> 530]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 64]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys
                      260                 265                 270         
          Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys
                  275                 280                 285             
          Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His
              290                 295                 300                 
          Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr
          305                 310                 315                 320 
          Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly
                          325                 330                 335     
          Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val
                      340                 345                 350         
          Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro
                  355                 360                 365             
          Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys
              370                 375                 380                 
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
          385                 390                 395                 400 
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                          405                 410                 415     
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                      420                 425                 430         
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                  435                 440                 445             
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
              450                 455                 460                 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
          465                 470                 475                 480 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                          485                 490                 495     
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                      500                 505                 510         
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                  515                 520                 525             
          Arg Gln
              530 
          <![CDATA[<210> 65]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 65]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 66]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 66]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 67]]>
          <![CDATA[<211> 458]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 67]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
                  275                 280                 285             
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
              290                 295                 300                 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
          305                 310                 315                 320 
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                          325                 330                 335     
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                      340                 345                 350         
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  355                 360                 365             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              370                 375                 380                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455             
          <![CDATA[<210> 68]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 68]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 69]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 69]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 70]]>
          <![CDATA[<211> 454]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 70]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val
                      260                 265                 270         
          Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr
                  275                 280                 285             
          Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala
              290                 295                 300                 
          Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe
          305                 310                 315                 320 
          Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val
                          325                 330                 335     
          Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg
                      340                 345                 350         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  355                 360                 365             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              370                 375                 380                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          385                 390                 395                 400 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          405                 410                 415     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      420                 425                 430         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  435                 440                 445             
          Ser Val Gln Glu Arg Gln
              450                 
          <![CDATA[<210> 71]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 71]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 72]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 72]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 73]]>
          <![CDATA[<211> 402]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 73]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                  275                 280                 285             
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
              290                 295                 300                 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
          305                 310                 315                 320 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                          325                 330                 335     
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      340                 345                 350         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  355                 360                 365             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              370                 375                 380                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          385                 390                 395                 400 
          Arg Gln
          <![CDATA[<210> 74]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 74]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 75]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 75]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 76]]>
          <![CDATA[<211> 398]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 76]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu
                      260                 265                 270         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  275                 280                 285             
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
              290                 295                 300                 
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
          305                 310                 315                 320 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                          325                 330                 335     
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                      340                 345                 350         
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                  355                 360                 365             
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
              370                 375                 380                 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395             
          <![CDATA[<210> 77]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 77]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 78]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 78]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 79]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 79]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln
              50                  55                  60                  
          Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn
                          165                 170                 175     
          Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 80]]>
          <![CDATA[<211> 536]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 80]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Glu Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
                  275                 280                 285             
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
              290                 295                 300                 
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
          305                 310                 315                 320 
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
                          325                 330                 335     
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
                      340                 345                 350         
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                  355                 360                 365             
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
              370                 375                 380                 
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
          385                 390                 395                 400 
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
                          405                 410                 415     
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                      420                 425                 430         
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  435                 440                 445             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              450                 455                 460                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          465                 470                 475                 480 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          485                 490                 495     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      500                 505                 510         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  515                 520                 525             
          Arg Ile Ser Val Gln Glu Arg Gln
              530                 535     
          <![CDATA[<210> 81]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 81]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 82]]>
          <![CDATA[<211> 529]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 82]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile Ala Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                      260                 265                 270         
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
                  275                 280                 285             
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
              290                 295                 300                 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
          305                 310                 315                 320 
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                          325                 330                 335     
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                      340                 345                 350         
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
                  355                 360                 365             
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
              370                 375                 380                 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
          385                 390                 395                 400 
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                          405                 410                 415     
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                      420                 425                 430         
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                  435                 440                 445             
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
              450                 455                 460                 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
          465                 470                 475                 480 
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                          485                 490                 495     
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                      500                 505                 510         
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                  515                 520                 525             
          Gln
          <![CDATA[<210> 83]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 83]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 84]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 84]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 85]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 85]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln
              50                  55                  60                  
          Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn
                          165                 170                 175     
          Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 86]]>
          <![CDATA[<211> 460]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 86]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Glu Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro
                  275                 280                 285             
          Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
              290                 295                 300                 
          Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
          305                 310                 315                 320 
          Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
                          325                 330                 335     
          Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
                      340                 345                 350         
          Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  355                 360                 365             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              370                 375                 380                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          385                 390                 395                 400 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          405                 410                 415     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      420                 425                 430         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  435                 440                 445             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460 
          <![CDATA[<210> 87]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 87]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 88]]>
          <![CDATA[<211> 453]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 88]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile Ala Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                      260                 265                 270         
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
                  275                 280                 285             
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
              290                 295                 300                 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
          305                 310                 315                 320 
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                          325                 330                 335     
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                      340                 345                 350         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  355                 360                 365             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              370                 375                 380                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          385                 390                 395                 400 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          405                 410                 415     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      420                 425                 430         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  435                 440                 445             
          Val Gln Glu Arg Gln
              450             
          <![CDATA[<210> 89]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 89]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 90]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 90]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 91]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 91]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln
              50                  55                  60                  
          Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn
                          165                 170                 175     
          Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 92]]>
          <![CDATA[<211> 404]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 92]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Glu Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                  275                 280                 285             
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
              290                 295                 300                 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
          305                 310                 315                 320 
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                          325                 330                 335     
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                      340                 345                 350         
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                  355                 360                 365             
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
              370                 375                 380                 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
          385                 390                 395                 400 
          Gln Glu Arg Gln
          <![CDATA[<210> 93]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 93]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 94]]>
          <![CDATA[<211> 397]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 94]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile Ala Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                      260                 265                 270         
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                  275                 280                 285             
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
              290                 295                 300                 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
          305                 310                 315                 320 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                          325                 330                 335     
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                      340                 345                 350         
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                  355                 360                 365             
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
              370                 375                 380                 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395         
          <![CDATA[<210> 95]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 95]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 96]]>
          <![CDATA[<211> 542]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 96]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe
          65                  70                  75                  80  
          Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr
                          85                  90                  95      
          Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr
                  115                 120                 125             
          Glu Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
                          165                 170                 175     
          Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile
                      180                 185                 190         
          Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn
                          245                 250                 255     
          Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met
                  275                 280                 285             
          Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr
              290                 295                 300                 
          Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp
          305                 310                 315                 320 
          Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu
                          325                 330                 335     
          Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn
                      340                 345                 350         
          Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp
                  355                 360                 365             
          Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp
              370                 375                 380                 
          Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu
          385                 390                 395                 400 
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
                          405                 410                 415     
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                      420                 425                 430         
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                  435                 440                 445             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              450                 455                 460                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          465                 470                 475                 480 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          485                 490                 495     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      500                 505                 510         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  515                 520                 525             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540         
          <![CDATA[<210> 97]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 97]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
                  35                  40                  45              
          Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser
                          85                  90                  95      
          Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr
                  115                 120                 125             
          Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 98]]>
          <![CDATA[<211> 541]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 98]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly
          65                  70                  75                  80  
          Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala
                          85                  90                  95      
          Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu
                  115                 120                 125             
          Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser
                          165                 170                 175     
          Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr
                      180                 185                 190         
          His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
          225                 230                 235                 240 
          Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr
                          245                 250                 255     
          Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu
                  275                 280                 285             
          Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn
              290                 295                 300                 
          Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser
          305                 310                 315                 320 
          Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln
                          325                 330                 335     
          Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu
                      340                 345                 350         
          Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile
                  355                 360                 365             
          Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn
              370                 375                 380                 
          Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys
          385                 390                 395                 400 
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
                          405                 410                 415     
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                      420                 425                 430         
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  435                 440                 445             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              450                 455                 460                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          465                 470                 475                 480 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          485                 490                 495     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      500                 505                 510         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  515                 520                 525             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540     
          <![CDATA[<210> 99]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 99]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 100]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 100]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
                      20                  25                  30          
          Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn
                  35                  40                  45              
          Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr Tyr Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
                  275                 280                 285             
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
              290                 295                 300                 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
          305                 310                 315                 320 
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                          325                 330                 335     
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                      340                 345                 350         
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                  355                 360                 365             
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
              370                 375                 380                 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
          385                 390                 395                 400 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                          405                 410                 415     
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                      420                 425                 430         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  435                 440                 445             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              450                 455                 460                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 101]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 101]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 102]]>
          <![CDATA[<211> 466]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 102]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe
          65                  70                  75                  80  
          Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr
                          85                  90                  95      
          Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr
                  115                 120                 125             
          Glu Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
                          165                 170                 175     
          Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile
                      180                 185                 190         
          Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn
                          245                 250                 255     
          Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala
                  275                 280                 285             
          Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
              290                 295                 300                 
          Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
          305                 310                 315                 320 
          Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
                          325                 330                 335     
          Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
                      340                 345                 350         
          Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser
                  355                 360                 365             
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
              370                 375                 380                 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
          385                 390                 395                 400 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                          405                 410                 415     
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                      420                 425                 430         
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                  435                 440                 445             
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
              450                 455                 460                 
          Arg Gln
          465     
          <![CDATA[<210> 103]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 103]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
                  35                  40                  45              
          Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser
                          85                  90                  95      
          Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr
                  115                 120                 125             
          Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 104]]>
          <![CDATA[<211> 465]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 104]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly
          65                  70                  75                  80  
          Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala
                          85                  90                  95      
          Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu
                  115                 120                 125             
          Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser
                          165                 170                 175     
          Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr
                      180                 185                 190         
          His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
          225                 230                 235                 240 
          Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr
                          245                 250                 255     
          Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys
                  275                 280                 285             
          Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
              290                 295                 300                 
          Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala
          305                 310                 315                 320 
          Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
                          325                 330                 335     
          Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
                      340                 345                 350         
          Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg
                  355                 360                 365             
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
              370                 375                 380                 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
          385                 390                 395                 400 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          405                 410                 415     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      420                 425                 430         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  435                 440                 445             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              450                 455                 460                 
          Gln
          465 
          <![CDATA[<210> 105]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 105]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 106]]>
          <![CDATA[<211> 458]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 106]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
                      20                  25                  30          
          Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn
                  35                  40                  45              
          Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr Tyr Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
                  275                 280                 285             
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
              290                 295                 300                 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
          305                 310                 315                 320 
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                          325                 330                 335     
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                      340                 345                 350         
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  355                 360                 365             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              370                 375                 380                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455             
          <![CDATA[<210> 107]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 107]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 108]]>
          <![CDATA[<211> 410]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 108]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe
          65                  70                  75                  80  
          Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr
                          85                  90                  95      
          Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr
                  115                 120                 125             
          Glu Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
                          165                 170                 175     
          Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile
                      180                 185                 190         
          Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn
                          245                 250                 255     
          Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly
                  275                 280                 285             
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
              290                 295                 300                 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
          305                 310                 315                 320 
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                          325                 330                 335     
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                      340                 345                 350         
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                  355                 360                 365             
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
              370                 375                 380                 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
          385                 390                 395                 400 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410 
          <![CDATA[<210> 109]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 109]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
                  35                  40                  45              
          Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser
                          85                  90                  95      
          Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr
                  115                 120                 125             
          Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 110]]>
          <![CDATA[<211> 409]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 110]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly
          65                  70                  75                  80  
          Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala
                          85                  90                  95      
          Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu
                  115                 120                 125             
          Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser
                          165                 170                 175     
          Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr
                      180                 185                 190         
          His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
          225                 230                 235                 240 
          Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr
                          245                 250                 255     
          Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly
                  275                 280                 285             
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
              290                 295                 300                 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
          305                 310                 315                 320 
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                          325                 330                 335     
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                      340                 345                 350         
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                  355                 360                 365             
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
              370                 375                 380                 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
          385                 390                 395                 400 
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 
          <![CDATA[<210> 111]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 111]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 112]]>
          <![CDATA[<211> 402]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 112]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
                      20                  25                  30          
          Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn
                  35                  40                  45              
          Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr Tyr Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                  275                 280                 285             
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
              290                 295                 300                 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
          305                 310                 315                 320 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                          325                 330                 335     
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      340                 345                 350         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  355                 360                 365             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              370                 375                 380                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          385                 390                 395                 400 
          Arg Gln
          <![CDATA[<210> 113]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 113]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 114]]>
          <![CDATA[<211> 539]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 114]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Leu Gln Glu Ser Gly Pro
                      20                  25                  30          
          Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
                  35                  40                  45              
          Gly Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro
              50                  55                  60                  
          Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile
          65                  70                  75                  80  
          Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp
                  115                 120                 125             
          Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val
          145                 150                 155                 160 
          His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser
                      180                 185                 190         
          Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala
                  275                 280                 285             
          Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe
              290                 295                 300                 
          Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val
          305                 310                 315                 320 
          Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr
                          325                 330                 335     
          Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val
                      340                 345                 350         
          Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe
                  355                 360                 365             
          Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys
              370                 375                 380                 
          Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
          385                 390                 395                 400 
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
                          405                 410                 415     
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                      420                 425                 430         
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                  435                 440                 445             
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
              450                 455                 460                 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
          465                 470                 475                 480 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          485                 490                 495     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      500                 505                 510         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  515                 520                 525             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 
          <![CDATA[<210> 115]]>
          <![CDATA[<211> 535]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 115]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg
                      20                  25                  30          
          Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile
                  35                  40                  45              
          Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn
          65                  70                  75                  80  
          Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn
                          85                  90                  95      
          Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val
                  115                 120                 125             
          Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr
                  195                 200                 205             
          Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln
                          245                 250                 255     
          Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala
                  275                 280                 285             
          Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe
              290                 295                 300                 
          Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val
          305                 310                 315                 320 
          Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly
                          325                 330                 335     
          Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu
                      340                 345                 350         
          Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu
                  355                 360                 365             
          Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr
              370                 375                 380                 
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
          385                 390                 395                 400 
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                          405                 410                 415     
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                      420                 425                 430         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  435                 440                 445             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              450                 455                 460                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          465                 470                 475                 480 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          485                 490                 495     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      500                 505                 510         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  515                 520                 525             
          Ile Ser Val Gln Glu Arg Gln
              530                 535 
          <![CDATA[<210> 116]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 116]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Leu Gln Glu Ser Gly Pro Gly
                      20                  25                  30          
          Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly
                  35                  40                  45              
          Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro
              50                  55                  60                  
          Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr
                  115                 120                 125             
          Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His
          145                 150                 155                 160 
          Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr
                      180                 185                 190         
          Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr
                          245                 250                 255     
          Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 117]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 117]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
                  275                 280                 285             
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
              290                 295                 300                 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
          305                 310                 315                 320 
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                          325                 330                 335     
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                      340                 345                 350         
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                  355                 360                 365             
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
              370                 375                 380                 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
          385                 390                 395                 400 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                          405                 410                 415     
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                      420                 425                 430         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  435                 440                 445             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              450                 455                 460                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 118]]>
          <![CDATA[<211> 531]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 118]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr
                      20                  25                  30          
          Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr
                  35                  40                  45              
          Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile
              50                  55                  60                  
          Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys
          65                  70                  75                  80  
          Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
                          85                  90                  95      
          Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                      100                 105                 110         
          Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly
                  115                 120                 125             
          Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
              210                 215                 220                 
          Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val
                          245                 250                 255     
          Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val
                      260                 265                 270         
          Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser
                  275                 280                 285             
          Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu
              290                 295                 300                 
          His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn
          305                 310                 315                 320 
          Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp
                          325                 330                 335     
          Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr
                      340                 345                 350         
          Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro
                  355                 360                 365             
          Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val
              370                 375                 380                 
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
          385                 390                 395                 400 
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                          405                 410                 415     
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
                      420                 425                 430         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  435                 440                 445             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              450                 455                 460                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          465                 470                 475                 480 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          485                 490                 495     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      500                 505                 510         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  515                 520                 525             
          Glu Arg Gln
              530     
          <![CDATA[<210> 119]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 119]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
                  275                 280                 285             
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
              290                 295                 300                 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
          305                 310                 315                 320 
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                          325                 330                 335     
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                      340                 345                 350         
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                  355                 360                 365             
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
              370                 375                 380                 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
          385                 390                 395                 400 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                          405                 410                 415     
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                      420                 425                 430         
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                  435                 440                 445             
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
              450                 455                 460                 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 120]]>
          <![CDATA[<211> 463]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220]]>> ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 120]]&gt;
          <br/><![CDATA[Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Leu Gln Glu Ser Gly Pro
                      20                  25                  30          
          Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
                  35                  40                  45              
          Gly Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro
              50                  55                  60                  
          Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile
          65                  70                  75                  80  
          Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp
                  115                 120                 125             
          Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val
          145                 150                 155                 160 
          His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser
                      180                 185                 190         
          Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr
                  275                 280                 285             
          Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
              290                 295                 300                 
          Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
          305                 310                 315                 320 
          Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
                          325                 330                 335     
          Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                      340                 345                 350         
          Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu
                  355                 360                 365             
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
              370                 375                 380                 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
          385                 390                 395                 400 
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                          405                 410                 415     
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                      420                 425                 430         
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                  435                 440                 445             
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460             
          <![CDATA[<210> 121]]>
          <![CDATA[<211> 459]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 121]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg
                      20                  25                  30          
          Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile
                  35                  40                  45              
          Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn
          65                  70                  75                  80  
          Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn
                          85                  90                  95      
          Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val
                  115                 120                 125             
          Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr
                  195                 200                 205             
          Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln
                          245                 250                 255     
          Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala
                  275                 280                 285             
          Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
              290                 295                 300                 
          Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
          305                 310                 315                 320 
          Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
                          325                 330                 335     
          Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
                      340                 345                 350         
          Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                  355                 360                 365             
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
              370                 375                 380                 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
          385                 390                 395                 400 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          405                 410                 415     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      420                 425                 430         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  435                 440                 445             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 
          <![CDATA[<210> 122]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 122]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Leu Gln Glu Ser Gly Pro Gly
                      20                  25                  30          
          Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly
                  35                  40                  45              
          Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro
              50                  55                  60                  
          Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr
                  115                 120                 125             
          Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His
          145                 150                 155                 160 
          Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr
                      180                 185                 190         
          Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr
                          245                 250                 255     
          Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 123]]>
          <![CDATA[<211> 458]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 123]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
                  275                 280                 285             
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
              290                 295                 300                 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
          305                 310                 315                 320 
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                          325                 330                 335     
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                      340                 345                 350         
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  355                 360                 365             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              370                 375                 380                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455             
          <![CDATA[<210> 124]]>
          <![CDATA[<211> 455]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 124]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr
                      20                  25                  30          
          Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr
                  35                  40                  45              
          Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile
              50                  55                  60                  
          Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys
          65                  70                  75                  80  
          Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
                          85                  90                  95      
          Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                      100                 105                 110         
          Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly
                  115                 120                 125             
          Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
              210                 215                 220                 
          Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val
                          245                 250                 255     
          Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro
                      260                 265                 270         
          Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro
                  275                 280                 285             
          Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
              290                 295                 300                 
          Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
          305                 310                 315                 320 
          Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                          325                 330                 335     
          Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn
                      340                 345                 350         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  355                 360                 365             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              370                 375                 380                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          385                 390                 395                 400 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          405                 410                 415     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      420                 425                 430         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  435                 440                 445             
          Ile Ser Val Gln Glu Arg Gln
              450                 455 
          <![CDATA[<210> 125]]>
          <![CDATA[<211> 458]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 125]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
                  275                 280                 285             
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
              290                 295                 300                 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
          305                 310                 315                 320 
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                          325                 330                 335     
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                      340                 345                 350         
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  355                 360                 365             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              370                 375                 380                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455             
          <![CDATA[<210> 126]]>
          <![CDATA[<211> 407]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 126]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Leu Gln Glu Ser Gly Pro
                      20                  25                  30          
          Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
                  35                  40                  45              
          Gly Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro
              50                  55                  60                  
          Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile
          65                  70                  75                  80  
          Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp
                  115                 120                 125             
          Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val
          145                 150                 155                 160 
          His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser
                      180                 185                 190         
          Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                  275                 280                 285             
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
              290                 295                 300                 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
          305                 310                 315                 320 
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                          325                 330                 335     
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                      340                 345                 350         
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                  355                 360                 365             
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
              370                 375                 380                 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
          385                 390                 395                 400 
          Ile Ser Val Gln Glu Arg Gln
                          405         
          <![CDATA[<210> 127]]>
          <![CDATA[<211> 403]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 127]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg
                      20                  25                  30          
          Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile
                  35                  40                  45              
          Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn
          65                  70                  75                  80  
          Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn
                          85                  90                  95      
          Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val
                  115                 120                 125             
          Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr
                  195                 200                 205             
          Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln
                          245                 250                 255     
          Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                  275                 280                 285             
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
              290                 295                 300                 
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
          305                 310                 315                 320 
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                          325                 330                 335     
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                      340                 345                 350         
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                  355                 360                 365             
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
              370                 375                 380                 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
          385                 390                 395                 400 
          Glu Arg Gln
          <![CDATA[<210> 128]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 128]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Leu Gln Glu Ser Gly Pro Gly
                      20                  25                  30          
          Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly
                  35                  40                  45              
          Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro
              50                  55                  60                  
          Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr
                  115                 120                 125             
          Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His
          145                 150                 155                 160 
          Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr
                      180                 185                 190         
          Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr
                          245                 250                 255     
          Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 129]]>
          <![CDATA[<211> 402]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 129]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                  275                 280                 285             
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
              290                 295                 300                 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
          305                 310                 315                 320 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                          325                 330                 335     
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      340                 345                 350         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  355                 360                 365             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              370                 375                 380                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          385                 390                 395                 400 
          Arg Gln
          <![CDATA[<210> 130]]>
          <![CDATA[<211> 399]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 130]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr
                      20                  25                  30          
          Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr
                  35                  40                  45              
          Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile
              50                  55                  60                  
          Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys
          65                  70                  75                  80  
          Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
                          85                  90                  95      
          Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                      100                 105                 110         
          Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly
                  115                 120                 125             
          Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
              210                 215                 220                 
          Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val
                          245                 250                 255     
          Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val
                      260                 265                 270         
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                  275                 280                 285             
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
              290                 295                 300                 
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
          305                 310                 315                 320 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                          325                 330                 335     
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                      340                 345                 350         
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                  355                 360                 365             
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
              370                 375                 380                 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 
          <![CDATA[<210> 131]]>
          <![CDATA[<211> 402]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 131]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                  275                 280                 285             
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
              290                 295                 300                 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
          305                 310                 315                 320 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                          325                 330                 335     
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      340                 345                 350         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  355                 360                 365             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              370                 375                 380                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          385                 390                 395                 400 
          Arg Gln
          <![CDATA[<210> 132]]>
          <![CDATA[<211> 543]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 132]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn
          65                  70                  75                  80  
          Gly Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                          85                  90                  95      
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
                      100                 105                 110         
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val
                  115                 120                 125             
          Ser Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
              130                 135                 140                 
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
          145                 150                 155                 160 
          Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile
                      180                 185                 190         
          Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                  195                 200                 205             
          Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile
          225                 230                 235                 240 
          Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr
                          245                 250                 255     
          Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      260                 265                 270         
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro
                  275                 280                 285             
          Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser
              290                 295                 300                 
          Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu
          305                 310                 315                 320 
          Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln
                          325                 330                 335     
          Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly
                      340                 345                 350         
          Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr
                  355                 360                 365             
          Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu
              370                 375                 380                 
          Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His
          385                 390                 395                 400 
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
                          405                 410                 415     
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                      420                 425                 430         
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                  435                 440                 445             
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
              450                 455                 460                 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
          465                 470                 475                 480 
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                          485                 490                 495     
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                      500                 505                 510         
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                  515                 520                 525             
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540             
          <![CDATA[<210> 133]]>
          <![CDATA[<211> 539]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 133]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys
          65                  70                  75                  80  
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                          85                  90                  95      
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala
                  115                 120                 125             
          Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
          145                 150                 155                 160 
          Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly
                      180                 185                 190         
          Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro
                          245                 250                 255     
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala
                  275                 280                 285             
          Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe
              290                 295                 300                 
          Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val
          305                 310                 315                 320 
          Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr
                          325                 330                 335     
          Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val
                      340                 345                 350         
          Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe
                  355                 360                 365             
          Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys
              370                 375                 380                 
          Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
          385                 390                 395                 400 
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
                          405                 410                 415     
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                      420                 425                 430         
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                  435                 440                 445             
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
              450                 455                 460                 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
          465                 470                 475                 480 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          485                 490                 495     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      500                 505                 510         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  515                 520                 525             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 
          <![CDATA[<210> 134]]>
          <![CDATA[<211> 542]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 134]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly
          65                  70                  75                  80  
          Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala
                          85                  90                  95      
          Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser
                  115                 120                 125             
          Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe
                      180                 185                 190         
          Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn
                          245                 250                 255     
          Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met
                  275                 280                 285             
          Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr
              290                 295                 300                 
          Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp
          305                 310                 315                 320 
          Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu
                          325                 330                 335     
          Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn
                      340                 345                 350         
          Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp
                  355                 360                 365             
          Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp
              370                 375                 380                 
          Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu
          385                 390                 395                 400 
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
                          405                 410                 415     
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                      420                 425                 430         
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                  435                 440                 445             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              450                 455                 460                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          465                 470                 475                 480 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          485                 490                 495     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      500                 505                 510         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  515                 520                 525             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540         
          <![CDATA[<210> 135]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 135]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 136]]>
          <![CDATA[<211> 535]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 136]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
              50                  55                  60                  
          Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Ala Asp Ser
          65                  70                  75                  80  
          Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp
                  115                 120                 125             
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser
          145                 150                 155                 160 
          Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                          165                 170                 175     
          Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala
                  195                 200                 205             
          Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly
                          245                 250                 255     
          Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala
                  275                 280                 285             
          Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe
              290                 295                 300                 
          Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val
          305                 310                 315                 320 
          Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly
                          325                 330                 335     
          Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu
                      340                 345                 350         
          Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu
                  355                 360                 365             
          Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr
              370                 375                 380                 
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
          385                 390                 395                 400 
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                          405                 410                 415     
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                      420                 425                 430         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  435                 440                 445             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              450                 455                 460                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          465                 470                 475                 480 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          485                 490                 495     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      500                 505                 510         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  515                 520                 525             
          Ile Ser Val Gln Glu Arg Gln
              530                 535 
          <![CDATA[<210> 137]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 137]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 138]]>
          <![CDATA[<211> 467]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 138]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn
          65                  70                  75                  80  
          Gly Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                          85                  90                  95      
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
                      100                 105                 110         
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val
                  115                 120                 125             
          Ser Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
              130                 135                 140                 
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
          145                 150                 155                 160 
          Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile
                      180                 185                 190         
          Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                  195                 200                 205             
          Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile
          225                 230                 235                 240 
          Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr
                          245                 250                 255     
          Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      260                 265                 270         
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro
                  275                 280                 285             
          Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
              290                 295                 300                 
          Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
          305                 310                 315                 320 
          Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
                          325                 330                 335     
          Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
                      340                 345                 350         
          Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg
                  355                 360                 365             
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
              370                 375                 380                 
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
          385                 390                 395                 400 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                          405                 410                 415     
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                      420                 425                 430         
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                  435                 440                 445             
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
              450                 455                 460                 
          Glu Arg Gln
          465         
          <![CDATA[<210> 139]]>
          <![CDATA[<211> 463]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 139]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys
          65                  70                  75                  80  
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                          85                  90                  95      
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala
                  115                 120                 125             
          Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
          145                 150                 155                 160 
          Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly
                      180                 185                 190         
          Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro
                          245                 250                 255     
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr
                  275                 280                 285             
          Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
              290                 295                 300                 
          Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly
          305                 310                 315                 320 
          Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp
                          325                 330                 335     
          Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
                      340                 345                 350         
          Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu
                  355                 360                 365             
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
              370                 375                 380                 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
          385                 390                 395                 400 
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                          405                 410                 415     
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                      420                 425                 430         
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                  435                 440                 445             
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460             
          <![CDATA[<210> 140]]>
          <![CDATA[<211> 466]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 140]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly
          65                  70                  75                  80  
          Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala
                          85                  90                  95      
          Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser
                  115                 120                 125             
          Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe
                      180                 185                 190         
          Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn
                          245                 250                 255     
          Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala
                  275                 280                 285             
          Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
              290                 295                 300                 
          Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
          305                 310                 315                 320 
          Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
                          325                 330                 335     
          Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
                      340                 345                 350         
          Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser
                  355                 360                 365             
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
              370                 375                 380                 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
          385                 390                 395                 400 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                          405                 410                 415     
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                      420                 425                 430         
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                  435                 440                 445             
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
              450                 455                 460                 
          Arg Gln
          465     
          <![CDATA[<210> 141]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 141]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 142]]>
          <![CDATA[<211> 459]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 142]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
              50                  55                  60                  
          Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Ala Asp Ser
          65                  70                  75                  80  
          Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp
                  115                 120                 125             
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser
          145                 150                 155                 160 
          Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                          165                 170                 175     
          Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala
                  195                 200                 205             
          Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly
                          245                 250                 255     
          Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala
                  275                 280                 285             
          Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
              290                 295                 300                 
          Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
          305                 310                 315                 320 
          Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
                          325                 330                 335     
          Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
                      340                 345                 350         
          Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                  355                 360                 365             
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
              370                 375                 380                 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
          385                 390                 395                 400 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          405                 410                 415     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      420                 425                 430         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  435                 440                 445             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 
          <![CDATA[<210> 143]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 143]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 144]]>
          <![CDATA[<211> 411]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 144]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn
          65                  70                  75                  80  
          Gly Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                          85                  90                  95      
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
                      100                 105                 110         
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val
                  115                 120                 125             
          Ser Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
              130                 135                 140                 
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
          145                 150                 155                 160 
          Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile
                      180                 185                 190         
          Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                  195                 200                 205             
          Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile
          225                 230                 235                 240 
          Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr
                          245                 250                 255     
          Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      260                 265                 270         
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val
                  275                 280                 285             
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
              290                 295                 300                 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
          305                 310                 315                 320 
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                          325                 330                 335     
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                      340                 345                 350         
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                  355                 360                 365             
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
              370                 375                 380                 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
          385                 390                 395                 400 
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410     
          <![CDATA[<210> 145]]>
          <![CDATA[<211> 407]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 145]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys
          65                  70                  75                  80  
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                          85                  90                  95      
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala
                  115                 120                 125             
          Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
          145                 150                 155                 160 
          Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly
                      180                 185                 190         
          Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro
                          245                 250                 255     
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                  275                 280                 285             
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
              290                 295                 300                 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
          305                 310                 315                 320 
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                          325                 330                 335     
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                      340                 345                 350         
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                  355                 360                 365             
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
              370                 375                 380                 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
          385                 390                 395                 400 
          Ile Ser Val Gln Glu Arg Gln
                          405         
          <![CDATA[<210> 146]]>
          <![CDATA[<211> 410]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 146]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly
          65                  70                  75                  80  
          Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala
                          85                  90                  95      
          Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser
                  115                 120                 125             
          Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe
                      180                 185                 190         
          Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn
                          245                 250                 255     
          Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly
                  275                 280                 285             
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
              290                 295                 300                 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
          305                 310                 315                 320 
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                          325                 330                 335     
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                      340                 345                 350         
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                  355                 360                 365             
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
              370                 375                 380                 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
          385                 390                 395                 400 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410 
          <![CDATA[<210> 147]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 147]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 148]]>
          <![CDATA[<211> 403]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 148]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
              50                  55                  60                  
          Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Ala Asp Ser
          65                  70                  75                  80  
          Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp
                  115                 120                 125             
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser
          145                 150                 155                 160 
          Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                          165                 170                 175     
          Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala
                  195                 200                 205             
          Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly
                          245                 250                 255     
          Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                  275                 280                 285             
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
              290                 295                 300                 
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
          305                 310                 315                 320 
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                          325                 330                 335     
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                      340                 345                 350         
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                  355                 360                 365             
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
              370                 375                 380                 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
          385                 390                 395                 400 
          Glu Arg Gln
          <![CDATA[<210> 149]]>
          <![CDATA[<211> 406]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 14]]>9
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                  275                 280                 285             
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
              290                 295                 300                 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
          305                 310                 315                 320 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                          325                 330                 335     
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                      340                 345                 350         
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                  355                 360                 365             
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
              370                 375                 380                 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
          385                 390                 395                 400 
          Ser Val Gln Glu Arg Gln
                          405     
          <![CDATA[<210> 150]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 150]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 151]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 151]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
                  275                 280                 285             
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
              290                 295                 300                 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          305                 310                 315                 320 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                          325                 330                 335     
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      340                 345                 350         
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 152]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 152]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> ]]>153
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 153]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 154]]>
          <![CDATA[<211> 419]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 154]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val
                      260                 265                 270         
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
                  275                 280                 285             
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
              290                 295                 300                 
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
          305                 310                 315                 320 
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                          325                 330                 335     
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                      340                 345                 350         
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                  355                 360                 365             
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
              370                 375                 380                 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
          385                 390                 395                 400 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                          405                 410                 415     
          Glu Arg Gln
          <![CDATA[<210> 155]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 155]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 156]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 156]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 157]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 157]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu
                      20                  25                  30          
          Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln
              50                  55                  60                  
          Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr
                          165                 170                 175     
          Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly
                          245                 250                 255     
          Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
                  275                 280                 285             
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
              290                 295                 300                 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          305                 310                 315                 320 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                          325                 330                 335     
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      340                 345                 350         
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 158]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220]]>> ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 158]]&gt;
          <br/><![CDATA[Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 159]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 159]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 160]]>
          <![CDATA[<211> 419]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 160]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly
                      20                  25                  30          
          Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu
                          245                 250                 255     
          Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val
                      260                 265                 270         
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
                  275                 280                 285             
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
              290                 295                 300                 
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
          305                 310                 315                 320 
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                          325                 330                 335     
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                      340                 345                 350         
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                  355                 360                 365             
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
              370                 375                 380                 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
          385                 390                 395                 400 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                          405                 410                 415     
          Glu Arg Gln
          <![CDATA[<210> 161]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 161]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val
                      20                  25                  30          
          Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 162]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 162]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 163]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 163]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln
              50                  55                  60                  
          Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu
          65                  70                  75                  80  
          Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser
                          85                  90                  95      
          Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe
                  115                 120                 125             
          Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn
                          165                 170                 175     
          Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn
                  195                 200                 205             
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 164]]>
          <![CDATA[<211> 425]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 164]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Lys Leu Glu Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly
              50                  55                  60                  
          Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly
          65                  70                  75                  80  
          Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr
                          85                  90                  95      
          Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro
                  115                 120                 125             
          Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
          145                 150                 155                 160 
          Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser
                  195                 200                 205             
          Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp
          225                 230                 235                 240 
          Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
                  275                 280                 285             
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
              290                 295                 300                 
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
          305                 310                 315                 320 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                          325                 330                 335     
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                      340                 345                 350         
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                  355                 360                 365             
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
              370                 375                 380                 
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
          385                 390                 395                 400 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                          405                 410                 415     
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425 
          <![CDATA[<210> 165]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 165]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 166]]>
          <![CDATA[<211> 418]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 166]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp
              50                  55                  60                  
          Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys
          65                  70                  75                  80  
          Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly
                  115                 120                 125             
          Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr Gln Ser Pro
          145                 150                 155                 160 
          Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile Ala Cys Ser
                          165                 170                 175     
          Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu
              210                 215                 220                 
          Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                      260                 265                 270         
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
                  275                 280                 285             
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
              290                 295                 300                 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
          305                 310                 315                 320 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                          325                 330                 335     
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                      340                 345                 350         
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                  355                 360                 365             
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
              370                 375                 380                 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
          385                 390                 395                 400 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                          405                 410                 415     
          Arg Gln
          <![CDATA[<210> 167]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 167]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg
              50                  55                  60                  
          Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr
          65                  70                  75                  80  
          Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Asn Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly Asp Arg Val Asn Ile
                          165                 170                 175     
          Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu Asp Ala Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 168]]>
          <![CDATA[<211> 431]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 168]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe
          65                  70                  75                  80  
          Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr
                          85                  90                  95      
          Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr
                  115                 120                 125             
          Glu Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala
                          165                 170                 175     
          Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile
                      180                 185                 190         
          Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn
                          245                 250                 255     
          Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His
                  275                 280                 285             
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
              290                 295                 300                 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
          305                 310                 315                 320 
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                          325                 330                 335     
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                      340                 345                 350         
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                  355                 360                 365             
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
              370                 375                 380                 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
          385                 390                 395                 400 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                          405                 410                 415     
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430     
          <![CDATA[<210> 169]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 169]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
                  35                  40                  45              
          Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser
                          85                  90                  95      
          Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr
                  115                 120                 125             
          Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 170]]>
          <![CDATA[<211> 430]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 170]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Gly Thr Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly
          65                  70                  75                  80  
          Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala
                          85                  90                  95      
          Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu
                  115                 120                 125             
          Leu Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser
                          165                 170                 175     
          Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr
                      180                 185                 190         
          His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
          225                 230                 235                 240 
          Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr
                          245                 250                 255     
          Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu
                  275                 280                 285             
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
              290                 295                 300                 
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
          305                 310                 315                 320 
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                          325                 330                 335     
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
                      340                 345                 350         
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                  355                 360                 365             
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
              370                 375                 380                 
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
          385                 390                 395                 400 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                          405                 410                 415     
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430 
          <![CDATA[<210> 171]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 171]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 172]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 172]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
                      20                  25                  30          
          Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn
                  35                  40                  45              
          Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr Tyr Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
                  275                 280                 285             
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
              290                 295                 300                 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          305                 310                 315                 320 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                          325                 330                 335     
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      340                 345                 350         
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 173]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 173]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr
                  35                  40                  45              
          Phe Ser Asn Ser Pro Ile Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Ser Ile Ile Pro Ser Phe Gly Thr Ala Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Leu Thr Ile Thr Ala Asp Glu Ser Thr
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Gly Arg Ser His Asn Tyr Glu Leu Tyr Tyr Tyr
                  115                 120                 125             
          Tyr Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 174]]>
          <![CDATA[<211> 428]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 174]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Leu Gln Glu Ser Gly Pro
                      20                  25                  30          
          Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser
                  35                  40                  45              
          Gly Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro
              50                  55                  60                  
          Pro Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile
          65                  70                  75                  80  
          Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp
                  115                 120                 125             
          Tyr Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val
          145                 150                 155                 160 
          His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Val Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser
                      180                 185                 190         
          Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro
                  275                 280                 285             
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
              290                 295                 300                 
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
          305                 310                 315                 320 
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                          325                 330                 335     
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                      340                 345                 350         
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                  355                 360                 365             
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
              370                 375                 380                 
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
          385                 390                 395                 400 
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                          405                 410                 415     
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425             
          <![CDATA[<210> 175]]>
          <![CDATA[<211> 424]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 175]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg
                      20                  25                  30          
          Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile
                  35                  40                  45              
          Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly
              50                  55                  60                  
          Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn
          65                  70                  75                  80  
          Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn
                          85                  90                  95      
          Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val
                  115                 120                 125             
          Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr
                  195                 200                 205             
          Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln
                          245                 250                 255     
          Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  275                 280                 285             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              290                 295                 300                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          305                 310                 315                 320 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          325                 330                 335     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      340                 345                 350         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                  355                 360                 365             
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
              370                 375                 380                 
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
          385                 390                 395                 400 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                          405                 410                 415     
          Arg Ile Ser Val Gln Glu Arg Gln
                      420                 
          <![CDATA[<210> 176]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 176]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Leu Gln Glu Ser Gly Pro Gly
                      20                  25                  30          
          Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly
                  35                  40                  45              
          Phe Thr Ile Ser Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro
              50                  55                  60                  
          Gly Arg Gly Leu Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr
                  115                 120                 125             
          Phe Asp Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His
          145                 150                 155                 160 
          Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr
                      180                 185                 190         
          Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr
                          245                 250                 255     
          Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 177]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 177]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
                  275                 280                 285             
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
              290                 295                 300                 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          305                 310                 315                 320 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                          325                 330                 335     
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      340                 345                 350         
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 178]]>
          <![CDATA[<211> 420]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 178]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr
                      20                  25                  30          
          Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser Ser Gly Tyr
                  35                  40                  45              
          Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile
              50                  55                  60                  
          Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu Lys
          65                  70                  75                  80  
          Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
                          85                  90                  95      
          Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                      100                 105                 110         
          Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly
                  115                 120                 125             
          Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
              210                 215                 220                 
          Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly Thr Lys Val
                          245                 250                 255     
          Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His
                      260                 265                 270         
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
                  275                 280                 285             
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
              290                 295                 300                 
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
          305                 310                 315                 320 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                          325                 330                 335     
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                      340                 345                 350         
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                  355                 360                 365             
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
              370                 375                 380                 
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
          385                 390                 395                 400 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                          405                 410                 415     
          Gln Glu Arg Gln
                      420 
          <![CDATA[<210> 179]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 179]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro
                      20                  25                  30          
          Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Ile Ser
                  35                  40                  45              
          Ser Gly Tyr Ser Trp His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Gln Tyr Ser Gly Ile Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Asp Tyr Asp Tyr His Trp Tyr Phe Asp Val Trp
                  115                 120                 125             
          Gly Gln Gly Ser Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Val His Ser Asp Ile Gln
          145                 150                 155                 160 
          Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Ser Thr Ser Ser Ser Val Ser Tyr Met His Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser
                  195                 200                 205             
          Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Thr Phe Gly Gln Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Arg Ala Ala Ala Gly Ser Gly Gly Ser Gly
                      260                 265                 270         
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
                  275                 280                 285             
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
              290                 295                 300                 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
          305                 310                 315                 320 
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                          325                 330                 335     
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                      340                 345                 350         
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 180]]>
          <![CDATA[<211> 432]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 180]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn
          65                  70                  75                  80  
          Gly Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser
                          85                  90                  95      
          Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg
                      100                 105                 110         
          Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val
                  115                 120                 125             
          Ser Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
              130                 135                 140                 
          Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
          145                 150                 155                 160 
          Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                          165                 170                 175     
          Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile
                      180                 185                 190         
          Phe Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala
                  195                 200                 205             
          Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile
          225                 230                 235                 240 
          Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr
                          245                 250                 255     
          Asn Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                      260                 265                 270         
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys
                  275                 280                 285             
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
              290                 295                 300                 
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
          305                 310                 315                 320 
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
                          325                 330                 335     
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                      340                 345                 350         
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                  355                 360                 365             
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
              370                 375                 380                 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
          385                 390                 395                 400 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                          405                 410                 415     
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430         
          <![CDATA[<210> 181]]>
          <![CDATA[<211> 428]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223>]]> 合成多肽
          <![CDATA[<400> 181]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys
          65                  70                  75                  80  
          Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                          85                  90                  95      
          Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala
                  115                 120                 125             
          Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
          145                 150                 155                 160 
          Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
                          165                 170                 175     
          Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly
                      180                 185                 190         
          Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
                  195                 200                 205             
          Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
          225                 230                 235                 240 
          Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro
                          245                 250                 255     
          Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly
                      260                 265                 270         
          Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro
                  275                 280                 285             
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
              290                 295                 300                 
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
          305                 310                 315                 320 
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                          325                 330                 335     
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                      340                 345                 350         
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                  355                 360                 365             
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
              370                 375                 380                 
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
          385                 390                 395                 400 
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                          405                 410                 415     
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425             
          <![CDATA[<210> 182]]>
          <![CDATA[<211> 431]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 182]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asn Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly
          65                  70                  75                  80  
          Asn Ser Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala
                          85                  90                  95      
          Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser
                  115                 120                 125             
          Asp Tyr Ala Met Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe
                      180                 185                 190         
          Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn
                          245                 250                 255     
          Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His
                  275                 280                 285             
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
              290                 295                 300                 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
          305                 310                 315                 320 
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                          325                 330                 335     
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                      340                 345                 350         
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                  355                 360                 365             
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
              370                 375                 380                 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
          385                 390                 395                 400 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                          405                 410                 415     
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430     
          <![CDATA[<210> 183]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 183]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 184]]>
          <![CDATA[<211> 424]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 184]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp
                  35                  40                  45              
          Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
              50                  55                  60                  
          Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Ala Asp Ser
          65                  70                  75                  80  
          Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala
                          85                  90                  95      
          Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp
                  115                 120                 125             
          Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser
          145                 150                 155                 160 
          Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                          165                 170                 175     
          Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe Leu His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala
                  195                 200                 205             
          Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr Thr Phe Gly
                          245                 250                 255     
          Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  275                 280                 285             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              290                 295                 300                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          305                 310                 315                 320 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          325                 330                 335     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      340                 345                 350         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                  355                 360                 365             
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
              370                 375                 380                 
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
          385                 390                 395                 400 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                          405                 410                 415     
          Arg Ile Ser Val Gln Glu Arg Gln
                      420                 
          <![CDATA[<210> 185]]>
          <![CDATA[<211> 427]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 185]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn
                  35                  40                  45              
          Ile Lys Asp Thr Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly
              50                  55                  60                  
          Leu Glu Trp Val Ala Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr
          65                  70                  75                  80  
          Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                          85                  90                  95      
          Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met
                  115                 120                 125             
          Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Arg Ala Gly Glu Ser Val Asp Ile Phe Gly Val Gly Phe
                      180                 185                 190         
          Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Glu Asp Pro Tyr
                          245                 250                 255     
          Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser
                  275                 280                 285             
          Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val
              290                 295                 300                 
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
          305                 310                 315                 320 
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                          325                 330                 335     
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
                      340                 345                 350         
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                  355                 360                 365             
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
              370                 375                 380                 
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
          385                 390                 395                 400 
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                          405                 410                 415     
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425         
          <![CDATA[<210> 186]]>
          <![CDATA[<211> 240]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 186]]>
          Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
                      20                  25                  30          
          Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
                  35                  40                  45              
          Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe
              50                  55                  60                  
          Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
          65                  70                  75                  80  
          Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                          85                  90                  95      
          Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly
                      100                 105                 110         
          Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile
              130                 135                 140                 
          Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser
          145                 150                 155                 160 
          Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser
                          165                 170                 175     
          Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro
                      180                 185                 190         
          Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile
                  195                 200                 205             
          Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp
              210                 215                 220                 
          Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
          225                 230                 235                 240 
          <![CDATA[<210> 187]]>
          <![CDATA[<211> 236]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 187]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
                      20                  25                  30          
          Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
                  35                  40                  45              
          Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
          65                  70                  75                  80  
          Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                      100                 105                 110         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
                  115                 120                 125             
          Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
              130                 135                 140                 
          Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg
          145                 150                 155                 160 
          Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                          165                 170                 175     
          Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe
                      180                 185                 190         
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  195                 200                 205             
          Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr
              210                 215                 220                 
          Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
          225                 230                 235     
          <![CDATA[<210> 188]]>
          <![CDATA[<211> 241]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 188]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala
           1               5                  10                  15      
          Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr
                      20                  25                  30          
          Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met
                  35                  40                  45              
          Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln
              50                  55                  60                  
          Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met
          65                  70                  75                  80  
          Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                          85                  90                  95      
          Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly
                      100                 105                 110         
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
              130                 135                 140                 
          Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          145                 150                 155                 160 
          Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
                          165                 170                 175     
          Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala
                      180                 185                 190         
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  195                 200                 205             
          Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
          225                 230                 235                 240 
          Lys
          <![CDATA[<210> 189]]>
          <![CDATA[<211> 241]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 189]]>
          Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
           1               5                  10                  15      
          Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
                      20                  25                  30          
          Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
                  35                  40                  45              
          Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
              50                  55                  60                  
          Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
          65                  70                  75                  80  
          Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                          85                  90                  95      
          Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln Gly
                      100                 105                 110         
          Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
              130                 135                 140                 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          145                 150                 155                 160 
          Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
                          165                 170                 175     
          Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
                      180                 185                 190         
          Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  195                 200                 205             
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
          225                 230                 235                 240 
          Lys
          <![CDATA[<210> 190]]>
          <![CDATA[<211> 249]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 190]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
           1               5                  10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe Tyr
                      20                  25                  30          
          Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                  35                  40                  45              
          Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser
              50                  55                  60                  
          Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
          65                  70                  75                  80  
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                          85                  90                  95      
          Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn
                      100                 105                 110         
          Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
              130                 135                 140                 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
          145                 150                 155                 160 
          Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr Gln
                          165                 170                 175     
          Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr
                      180                 185                 190         
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
                  195                 200                 205             
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr
              210                 215                 220                 
          Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His Ala
          225                 230                 235                 240 
          Phe Gly Gly Gly Thr Lys Val Glu Ile
                          245                 
          <![CDATA[<210> 191]]>
          <![CDATA[<211> 2]]>54
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 191]]>
          Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln
           1               5                  10                  15      
          Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn
                      20                  25                  30          
          Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
                  35                  40                  45              
          Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala
              50                  55                  60                  
          Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn
          65                  70                  75                  80  
          Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val
                          85                  90                  95      
          Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val
                      100                 105                 110         
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
                  115                 120                 125             
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln
              130                 135                 140                 
          Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys
          145                 150                 155                 160 
          Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr
                          165                 170                 175     
          Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser
                      180                 185                 190         
          Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
                  195                 200                 205             
          Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu
              210                 215                 220                 
          Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser
          225                 230                 235                 240 
          Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser
                          245                 250                 
          <![CDATA[<210> 192]]>
          <![CDATA[<211> 536]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 192]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn
          65                  70                  75                  80  
          Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly
                  115                 120                 125             
          Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp
                  195                 200                 205             
          Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp
          225                 230                 235                 240 
          Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
                  275                 280                 285             
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
              290                 295                 300                 
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
          305                 310                 315                 320 
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
                          325                 330                 335     
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
                      340                 345                 350         
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                  355                 360                 365             
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
              370                 375                 380                 
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
          385                 390                 395                 400 
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
                          405                 410                 415     
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                      420                 425                 430         
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  435                 440                 445             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              450                 455                 460                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          465                 470                 475                 480 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          485                 490                 495     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      500                 505                 510         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  515                 520                 525             
          Arg Ile Ser Val Gln Glu Arg Gln
              530                 535     
          <![CDATA[<210> 193]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 193]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys
              50                  55                  60                  
          Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser
          65                  70                  75                  80  
          Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                          85                  90                  95      
          Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser
                      100                 105                 110         
          Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 194]]>
          <![CDATA[<211> 535]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 194]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser
              50                  55                  60                  
          His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly
          65                  70                  75                  80  
          Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val
                          85                  90                  95      
          Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg
                  115                 120                 125             
          Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
                          165                 170                 175     
          Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
                  195                 200                 205             
          Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly
                          245                 250                 255     
          Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala
                  275                 280                 285             
          Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe
              290                 295                 300                 
          Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val
          305                 310                 315                 320 
          Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly
                          325                 330                 335     
          Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu
                      340                 345                 350         
          Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu
                  355                 360                 365             
          Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr
              370                 375                 380                 
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
          385                 390                 395                 400 
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                          405                 410                 415     
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                      420                 425                 430         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  435                 440                 445             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              450                 455                 460                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          465                 470                 475                 480 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          485                 490                 495     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      500                 505                 510         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  515                 520                 525             
          Ile Ser Val Gln Glu Arg Gln
              530                 535 
          <![CDATA[<210> 195]]>
          <![CDATA[<211> 531]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 195]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val
                      260                 265                 270         
          Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser
                  275                 280                 285             
          Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu
              290                 295                 300                 
          His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn
          305                 310                 315                 320 
          Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp
                          325                 330                 335     
          Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr
                      340                 345                 350         
          Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro
                  355                 360                 365             
          Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val
              370                 375                 380                 
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
          385                 390                 395                 400 
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                          405                 410                 415     
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
                      420                 425                 430         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  435                 440                 445             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              450                 455                 460                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          465                 470                 475                 480 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          485                 490                 495     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      500                 505                 510         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  515                 520                 525             
          Glu Arg Gln
              530     
          <![CDATA[<210> 196]]>
          <![CDATA[<211> 528]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 196]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
                  35                  40                  45              
          Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp
              50                  55                  60                  
          Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys
          65                  70                  75                  80  
          Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
                          85                  90                  95      
          Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
                      100                 105                 110         
          Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala
          145                 150                 155                 160 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala
                          165                 170                 175     
          Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr
                      180                 185                 190         
          Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val
                  195                 200                 205             
          Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr
              210                 215                 220                 
          Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln
          225                 230                 235                 240 
          Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser
                      260                 265                 270         
          Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr
                  275                 280                 285             
          Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly
              290                 295                 300                 
          Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln
          305                 310                 315                 320 
          Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu
                          325                 330                 335     
          Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln
                      340                 345                 350         
          Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr
                  355                 360                 365             
          Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys
              370                 375                 380                 
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
          385                 390                 395                 400 
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                          405                 410                 415     
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
                      420                 425                 430         
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                  435                 440                 445             
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
              450                 455                 460                 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
          465                 470                 475                 480 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                          485                 490                 495     
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                      500                 505                 510         
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525             
          <![CDATA[<210> 197]]>
          <![CDATA[<211> 531]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 197]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val
                      260                 265                 270         
          Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser
                  275                 280                 285             
          Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu
              290                 295                 300                 
          His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn
          305                 310                 315                 320 
          Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp
                          325                 330                 335     
          Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr
                      340                 345                 350         
          Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro
                  355                 360                 365             
          Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val
              370                 375                 380                 
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
          385                 390                 395                 400 
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                          405                 410                 415     
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
                      420                 425                 430         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  435                 440                 445             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              450                 455                 460                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          465                 470                 475                 480 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          485                 490                 495     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      500                 505                 510         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  515                 520                 525             
          Glu Arg Gln
              530     
          <![CDATA[<210> 198]]>
          <![CDATA[<211> 460]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 198]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn
          65                  70                  75                  80  
          Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly
                  115                 120                 125             
          Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp
                  195                 200                 205             
          Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp
          225                 230                 235                 240 
          Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro
                  275                 280                 285             
          Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
              290                 295                 300                 
          Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
          305                 310                 315                 320 
          Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
                          325                 330                 335     
          Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
                      340                 345                 350         
          Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  355                 360                 365             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              370                 375                 380                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          385                 390                 395                 400 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          405                 410                 415     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      420                 425                 430         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  435                 440                 445             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460 
          <![CDATA[<210> 199]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 199]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys
              50                  55                  60                  
          Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser
          65                  70                  75                  80  
          Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                          85                  90                  95      
          Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser
                      100                 105                 110         
          Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 200]]>
          <![CDATA[<211> 459]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 200]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser
              50                  55                  60                  
          His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly
          65                  70                  75                  80  
          Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val
                          85                  90                  95      
          Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg
                  115                 120                 125             
          Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
                          165                 170                 175     
          Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
                  195                 200                 205             
          Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly
                          245                 250                 255     
          Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala
                  275                 280                 285             
          Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
              290                 295                 300                 
          Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
          305                 310                 315                 320 
          Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
                          325                 330                 335     
          Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
                      340                 345                 350         
          Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
                  355                 360                 365             
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
              370                 375                 380                 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
          385                 390                 395                 400 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          405                 410                 415     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      420                 425                 430         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  435                 440                 445             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 
          <![CDATA[<210> 201]]>
          <![CDATA[<211> 455]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 201]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro
                      260                 265                 270         
          Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro
                  275                 280                 285             
          Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
              290                 295                 300                 
          Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
          305                 310                 315                 320 
          Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                          325                 330                 335     
          Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn
                      340                 345                 350         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  355                 360                 365             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              370                 375                 380                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          385                 390                 395                 400 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          405                 410                 415     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      420                 425                 430         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  435                 440                 445             
          Ile Ser Val Gln Glu Arg Gln
              450                 455 
          <![CDATA[<210> 202]]>
          <![CDATA[<211> 452]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 202]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
                  35                  40                  45              
          Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp
              50                  55                  60                  
          Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys
          65                  70                  75                  80  
          Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
                          85                  90                  95      
          Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
                      100                 105                 110         
          Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala
          145                 150                 155                 160 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala
                          165                 170                 175     
          Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr
                      180                 185                 190         
          Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val
                  195                 200                 205             
          Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr
              210                 215                 220                 
          Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln
          225                 230                 235                 240 
          Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu
                      260                 265                 270         
          Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala
                  275                 280                 285             
          Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
              290                 295                 300                 
          Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys
          305                 310                 315                 320 
          Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
                          325                 330                 335     
          Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys
                      340                 345                 350         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  355                 360                 365             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              370                 375                 380                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          385                 390                 395                 400 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          405                 410                 415     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      420                 425                 430         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  435                 440                 445             
          Gln Glu Arg Gln
              450         
          <![CDATA[<210> 203]]>
          <![CDATA[<211> 455]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 203]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro
                      260                 265                 270         
          Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro
                  275                 280                 285             
          Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
              290                 295                 300                 
          Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
          305                 310                 315                 320 
          Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                          325                 330                 335     
          Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn
                      340                 345                 350         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  355                 360                 365             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              370                 375                 380                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          385                 390                 395                 400 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          405                 410                 415     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      420                 425                 430         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  435                 440                 445             
          Ile Ser Val Gln Glu Arg Gln
              450                 455 
          <![CDATA[<210> 204]]>
          <![CDATA[<211> 404]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 204]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn
          65                  70                  75                  80  
          Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly
                  115                 120                 125             
          Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp
                  195                 200                 205             
          Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp
          225                 230                 235                 240 
          Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                  275                 280                 285             
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
              290                 295                 300                 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
          305                 310                 315                 320 
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                          325                 330                 335     
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                      340                 345                 350         
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                  355                 360                 365             
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
              370                 375                 380                 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
          385                 390                 395                 400 
          Gln Glu Arg Gln
          <![CDATA[<210> 205]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 205]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys
              50                  55                  60                  
          Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser
          65                  70                  75                  80  
          Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                          85                  90                  95      
          Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser
                      100                 105                 110         
          Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 206]]>
          <![CDATA[<211> 403]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 206]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser
              50                  55                  60                  
          His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly
          65                  70                  75                  80  
          Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val
                          85                  90                  95      
          Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg
                  115                 120                 125             
          Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
                          165                 170                 175     
          Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
                  195                 200                 205             
          Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly
                          245                 250                 255     
          Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                  275                 280                 285             
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
              290                 295                 300                 
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
          305                 310                 315                 320 
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                          325                 330                 335     
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                      340                 345                 350         
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                  355                 360                 365             
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
              370                 375                 380                 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
          385                 390                 395                 400 
          Glu Arg Gln
          <![CDATA[<210> 207]]>
          <![CDATA[<211> 399]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 207]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val
                      260                 265                 270         
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                  275                 280                 285             
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
              290                 295                 300                 
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
          305                 310                 315                 320 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                          325                 330                 335     
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                      340                 345                 350         
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                  355                 360                 365             
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
              370                 375                 380                 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 
          <![CDATA[<210> 208]]>
          <![CDATA[<211> 396]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 208]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
                  35                  40                  45              
          Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp
              50                  55                  60                  
          Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys
          65                  70                  75                  80  
          Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
                          85                  90                  95      
          Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
                      100                 105                 110         
          Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala
          145                 150                 155                 160 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala
                          165                 170                 175     
          Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr
                      180                 185                 190         
          Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val
                  195                 200                 205             
          Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr
              210                 215                 220                 
          Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln
          225                 230                 235                 240 
          Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val
                      260                 265                 270         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  275                 280                 285             
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
              290                 295                 300                 
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
          305                 310                 315                 320 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                          325                 330                 335     
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                      340                 345                 350         
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                  355                 360                 365             
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
              370                 375                 380                 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395     
          <![CDATA[<210> 209]]>
          <![CDATA[<211> 399]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 209]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val
                      260                 265                 270         
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                  275                 280                 285             
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
              290                 295                 300                 
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
          305                 310                 315                 320 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                          325                 330                 335     
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                      340                 345                 350         
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                  355                 360                 365             
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
              370                 375                 380                 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 
          <![CDATA[<210> 210]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 210]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser
          65                  70                  75                  80  
          Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr
                          85                  90                  95      
          Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
                      100                 105                 110         
          Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile
                  195                 200                 205             
          Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 211]]>
          <![CDATA[<211> 528]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 211]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
                          85                  90                  95      
          Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
          225                 230                 235                 240 
          Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser
                      260                 265                 270         
          Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr
                  275                 280                 285             
          Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly
              290                 295                 300                 
          Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln
          305                 310                 315                 320 
          Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu
                          325                 330                 335     
          Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln
                      340                 345                 350         
          Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr
                  355                 360                 365             
          Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys
              370                 375                 380                 
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
          385                 390                 395                 400 
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                          405                 410                 415     
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
                      420                 425                 430         
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                  435                 440                 445             
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
              450                 455                 460                 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
          465                 470                 475                 480 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                          485                 490                 495     
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                      500                 505                 510         
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525             
          <![CDATA[<210> 212]]>
          <![CDATA[<211> 531]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 212]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly
          65                  70                  75                  80  
          Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg
                          85                  90                  95      
          Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
                      100                 105                 110         
          Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu
                  195                 200                 205             
          Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys
                          245                 250                 255     
          Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val
                      260                 265                 270         
          Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser
                  275                 280                 285             
          Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu
              290                 295                 300                 
          His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn
          305                 310                 315                 320 
          Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp
                          325                 330                 335     
          Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr
                      340                 345                 350         
          Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro
                  355                 360                 365             
          Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val
              370                 375                 380                 
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
          385                 390                 395                 400 
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
                          405                 410                 415     
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
                      420                 425                 430         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  435                 440                 445             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              450                 455                 460                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          465                 470                 475                 480 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          485                 490                 495     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      500                 505                 510         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  515                 520                 525             
          Glu Arg Gln
              530     
          <![CDATA[<210> 213]]>
          <![CDATA[<211> 527]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 213]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro
                      260                 265                 270         
          Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser
                  275                 280                 285             
          Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu
              290                 295                 300                 
          Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln
          305                 310                 315                 320 
          Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly
                          325                 330                 335     
          Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr
                      340                 345                 350         
          Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu
                  355                 360                 365             
          Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His
              370                 375                 380                 
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
          385                 390                 395                 400 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                          405                 410                 415     
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                      420                 425                 430         
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                  435                 440                 445             
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
              450                 455                 460                 
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
          465                 470                 475                 480 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                          485                 490                 495     
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                      500                 505                 510         
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525         
          <![CDATA[<210> 214]]>
          <![CDATA[<211> 524]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 214]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp
                  35                  40                  45              
          Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  115                 120                 125             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
          145                 150                 155                 160 
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
                          165                 170                 175     
          Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                      180                 185                 190         
          Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg
                  195                 200                 205             
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
              210                 215                 220                 
          Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr
          225                 230                 235                 240 
          Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Ala Ala Ala
                          245                 250                 255     
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                      260                 265                 270         
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
                  275                 280                 285             
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
              290                 295                 300                 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
          305                 310                 315                 320 
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                          325                 330                 335     
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                      340                 345                 350         
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
                  355                 360                 365             
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
              370                 375                 380                 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
          385                 390                 395                 400 
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                          405                 410                 415     
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                      420                 425                 430         
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                  435                 440                 445             
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
              450                 455                 460                 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
          465                 470                 475                 480 
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                          485                 490                 495     
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                      500                 505                 510         
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 
          <![CDATA[<210> 215]]>
          <![CDATA[<211> 527]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 215]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro
                      260                 265                 270         
          Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser
                  275                 280                 285             
          Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu
              290                 295                 300                 
          Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln
          305                 310                 315                 320 
          Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly
                          325                 330                 335     
          Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr
                      340                 345                 350         
          Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu
                  355                 360                 365             
          Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His
              370                 375                 380                 
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
          385                 390                 395                 400 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                          405                 410                 415     
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                      420                 425                 430         
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                  435                 440                 445             
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
              450                 455                 460                 
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
          465                 470                 475                 480 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                          485                 490                 495     
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                      500                 505                 510         
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525         
          <![CDATA[<210> 216]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 216]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser
          65                  70                  75                  80  
          Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr
                          85                  90                  95      
          Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
                      100                 105                 110         
          Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile
                  195                 200                 205             
          Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 217]]>
          <![CDATA[<211> 452]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 217]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
                          85                  90                  95      
          Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
          225                 230                 235                 240 
          Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu
                      260                 265                 270         
          Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala
                  275                 280                 285             
          Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
              290                 295                 300                 
          Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys
          305                 310                 315                 320 
          Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
                          325                 330                 335     
          Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys
                      340                 345                 350         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  355                 360                 365             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              370                 375                 380                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          385                 390                 395                 400 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          405                 410                 415     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      420                 425                 430         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  435                 440                 445             
          Gln Glu Arg Gln
              450         
          <![CDATA[<210> 218]]>
          <![CDATA[<211> 455]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 218]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly
          65                  70                  75                  80  
          Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg
                          85                  90                  95      
          Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
                      100                 105                 110         
          Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu
                  195                 200                 205             
          Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys
                          245                 250                 255     
          Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro
                      260                 265                 270         
          Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro
                  275                 280                 285             
          Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
              290                 295                 300                 
          Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
          305                 310                 315                 320 
          Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
                          325                 330                 335     
          Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn
                      340                 345                 350         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  355                 360                 365             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              370                 375                 380                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          385                 390                 395                 400 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          405                 410                 415     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      420                 425                 430         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  435                 440                 445             
          Ile Ser Val Gln Glu Arg Gln
              450                 455 
          <![CDATA[<210> 219]]>
          <![CDATA[<211> 451]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 219]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro
                      260                 265                 270         
          Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
                  275                 280                 285             
          Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
              290                 295                 300                 
          Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
          305                 310                 315                 320 
          Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
                          325                 330                 335     
          Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg
                      340                 345                 350         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  355                 360                 365             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              370                 375                 380                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          385                 390                 395                 400 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          405                 410                 415     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      420                 425                 430         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  435                 440                 445             
          Glu Arg Gln
              450     
          <![CDATA[<210>]]> 220
          <![CDATA[<211> 448]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 220]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp
                  35                  40                  45              
          Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  115                 120                 125             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
          145                 150                 155                 160 
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
                          165                 170                 175     
          Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                      180                 185                 190         
          Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg
                  195                 200                 205             
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
              210                 215                 220                 
          Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr
          225                 230                 235                 240 
          Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Ala Ala Ala
                          245                 250                 255     
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                      260                 265                 270         
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                  275                 280                 285             
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
              290                 295                 300                 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
          305                 310                 315                 320 
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                          325                 330                 335     
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu
                      340                 345                 350         
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                  355                 360                 365             
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
              370                 375                 380                 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
          385                 390                 395                 400 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                          405                 410                 415     
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                      420                 425                 430         
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  435                 440                 445             
          <![CDATA[<210> 221]]>
          <![CDATA[<211> 451]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 221]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro
                      260                 265                 270         
          Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
                  275                 280                 285             
          Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
              290                 295                 300                 
          Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
          305                 310                 315                 320 
          Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
                          325                 330                 335     
          Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg
                      340                 345                 350         
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                  355                 360                 365             
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
              370                 375                 380                 
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
          385                 390                 395                 400 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                          405                 410                 415     
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                      420                 425                 430         
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                  435                 440                 445             
          Glu Arg Gln
              450     
          <![CDATA[<210> 222]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 222]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser
          65                  70                  75                  80  
          Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr
                          85                  90                  95      
          Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
                      100                 105                 110         
          Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile
                  195                 200                 205             
          Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 223]]>
          <![CDATA[<211> 396]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 223]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
                          85                  90                  95      
          Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
          225                 230                 235                 240 
          Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val
                      260                 265                 270         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  275                 280                 285             
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
              290                 295                 300                 
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
          305                 310                 315                 320 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                          325                 330                 335     
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                      340                 345                 350         
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                  355                 360                 365             
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
              370                 375                 380                 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395     
          <![CDATA[<210> 224]]>
          <![CDATA[<211> 399]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 224]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly
          65                  70                  75                  80  
          Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg
                          85                  90                  95      
          Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
                      100                 105                 110         
          Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu
                  195                 200                 205             
          Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys
                          245                 250                 255     
          Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val
                      260                 265                 270         
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
                  275                 280                 285             
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
              290                 295                 300                 
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
          305                 310                 315                 320 
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                          325                 330                 335     
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                      340                 345                 350         
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                  355                 360                 365             
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
              370                 375                 380                 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 
          <![CDATA[<210> 225]]>
          <![CDATA[<211> 395]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 225]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val
                      260                 265                 270         
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                  275                 280                 285             
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
              290                 295                 300                 
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
          305                 310                 315                 320 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                          325                 330                 335     
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                      340                 345                 350         
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                  355                 360                 365             
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
              370                 375                 380                 
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395 
          <![CDATA[<210> 226]]>
          <![CDATA[<211> 392]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 226]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp
                  35                  40                  45              
          Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  115                 120                 125             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
          145                 150                 155                 160 
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
                          165                 170                 175     
          Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                      180                 185                 190         
          Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg
                  195                 200                 205             
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
              210                 215                 220                 
          Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr
          225                 230                 235                 240 
          Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Ala Ala Ala
                          245                 250                 255     
          Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val
                      260                 265                 270         
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                  275                 280                 285             
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
              290                 295                 300                 
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
          305                 310                 315                 320 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                          325                 330                 335     
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                      340                 345                 350         
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                  355                 360                 365             
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
              370                 375                 380                 
          Arg Ile Ser Val Gln Glu Arg Gln
          385                 390         
          <![CDATA[<210> 227]]>
          <![CDATA[<211> 395]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 227]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val
                      260                 265                 270         
          Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile
                  275                 280                 285             
          Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr
              290                 295                 300                 
          Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln
          305                 310                 315                 320 
          Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val
                          325                 330                 335     
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                      340                 345                 350         
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                  355                 360                 365             
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
              370                 375                 380                 
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395 
          <![CDATA[<210> 228]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 228]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly
          65                  70                  75                  80  
          Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn
                          85                  90                  95      
          Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser
                      100                 105                 110         
          Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp
                  115                 120                 125             
          Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 229]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 229]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr
                          85                  90                  95      
          Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 230]]>
          <![CDATA[<211> 536]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 230]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val
          65                  70                  75                  80  
          Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp
                          85                  90                  95      
          Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
                  275                 280                 285             
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
              290                 295                 300                 
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
          305                 310                 315                 320 
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
                          325                 330                 335     
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
                      340                 345                 350         
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                  355                 360                 365             
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
              370                 375                 380                 
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
          385                 390                 395                 400 
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
                          405                 410                 415     
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                      420                 425                 430         
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  435                 440                 445             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              450                 455                 460                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          465                 470                 475                 480 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          485                 490                 495     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      500                 505                 510         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  515                 520                 525             
          Arg Ile Ser Val Gln Glu Arg Gln
              530                 535     
          <![CDATA[<210> 231]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 231]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 232]]>
          <![CDATA[<211> 529]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 232]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly
                      20                  25                  30          
          Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr
                  35                  40                  45              
          Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe
          65                  70                  75                  80  
          Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr
                          85                  90                  95      
          Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                      100                 105                 110         
          Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
                  195                 200                 205             
          Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                      260                 265                 270         
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
                  275                 280                 285             
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
              290                 295                 300                 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
          305                 310                 315                 320 
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                          325                 330                 335     
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                      340                 345                 350         
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
                  355                 360                 365             
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
              370                 375                 380                 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
          385                 390                 395                 400 
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                          405                 410                 415     
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                      420                 425                 430         
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                  435                 440                 445             
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
              450                 455                 460                 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
          465                 470                 475                 480 
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                          485                 490                 495     
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                      500                 505                 510         
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                  515                 520                 525             
          Gln
          <![CDATA[<210> 233]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 233]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 234]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 234]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly
          65                  70                  75                  80  
          Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn
                          85                  90                  95      
          Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser
                      100                 105                 110         
          Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp
                  115                 120                 125             
          Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 235]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 235]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr
                          85                  90                  95      
          Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 236]]>
          <![CDATA[<211> 460]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 236]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val
          65                  70                  75                  80  
          Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp
                          85                  90                  95      
          Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro
                  275                 280                 285             
          Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
              290                 295                 300                 
          Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
          305                 310                 315                 320 
          Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
                          325                 330                 335     
          Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
                      340                 345                 350         
          Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  355                 360                 365             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              370                 375                 380                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          385                 390                 395                 400 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          405                 410                 415     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      420                 425                 430         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  435                 440                 445             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460 
          <![CDATA[<210> 237]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 237]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 238]]>
          <![CDATA[<211> 453]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 238]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly
                      20                  25                  30          
          Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr
                  35                  40                  45              
          Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe
          65                  70                  75                  80  
          Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr
                          85                  90                  95      
          Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                      100                 105                 110         
          Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
                  195                 200                 205             
          Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                      260                 265                 270         
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
                  275                 280                 285             
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
              290                 295                 300                 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
          305                 310                 315                 320 
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                          325                 330                 335     
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                      340                 345                 350         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  355                 360                 365             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              370                 375                 380                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          385                 390                 395                 400 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          405                 410                 415     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      420                 425                 430         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  435                 440                 445             
          Val Gln Glu Arg Gln
              450             
          <![CDATA[<210> 239]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 239]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 240]]>
          <![CDATA[<211> 508]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 240]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly
          65                  70                  75                  80  
          Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn
                          85                  90                  95      
          Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser
                      100                 105                 110         
          Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp
                  115                 120                 125             
          Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                          405                 410                 415     
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                      420                 425                 430         
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                  435                 440                 445             
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
              450                 455                 460                 
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
          465                 470                 475                 480 
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                          485                 490                 495     
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      500                 505             
          <![CDATA[<210> 24]]>1
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 241]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr
                          85                  90                  95      
          Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 242]]>
          <![CDATA[<211> 404]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 242]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val
          65                  70                  75                  80  
          Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp
                          85                  90                  95      
          Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                  275                 280                 285             
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
              290                 295                 300                 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
          305                 310                 315                 320 
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                          325                 330                 335     
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                      340                 345                 350         
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                  355                 360                 365             
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
              370                 375                 380                 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
          385                 390                 395                 400 
          Gln Glu Arg Gln
          <![CDATA[<210> 243]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 243]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 244]]>
          <![CDATA[<211> 397]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 244]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly
                      20                  25                  30          
          Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr
                  35                  40                  45              
          Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe
          65                  70                  75                  80  
          Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr
                          85                  90                  95      
          Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                      100                 105                 110         
          Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
                  195                 200                 205             
          Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                      260                 265                 270         
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                  275                 280                 285             
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
              290                 295                 300                 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
          305                 310                 315                 320 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                          325                 330                 335     
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                      340                 345                 350         
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                  355                 360                 365             
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
              370                 375                 380                 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395         
          <![CDATA[<210> 245]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 245]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 246]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 246]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Glu Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr
                  35                  40                  45              
          Val Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile
              50                  55                  60                  
          Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr
          65                  70                  75                  80  
          Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile
                          85                  90                  95      
          Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val
                      100                 105                 110         
          Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn
                  115                 120                 125             
          Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 247]]>
          <![CDATA[<211> 533]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 247]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
                  35                  40                  45              
          Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro
              50                  55                  60                  
          Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp
                  115                 120                 125             
          Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser
                  195                 200                 205             
          Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
                  275                 280                 285             
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
              290                 295                 300                 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
          305                 310                 315                 320 
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                          325                 330                 335     
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                      340                 345                 350         
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
                  355                 360                 365             
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
              370                 375                 380                 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
          385                 390                 395                 400 
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                          405                 410                 415     
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                      420                 425                 430         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  435                 440                 445             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              450                 455                 460                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          465                 470                 475                 480 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          485                 490                 495     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      500                 505                 510         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  515                 520                 525             
          Val Gln Glu Arg Gln
              530             
          <![CDATA[<210> 248]]>
          <![CDATA[<211> 536]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 248]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Glu Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val
                  35                  40                  45              
          Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg
              50                  55                  60                  
          Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser
          65                  70                  75                  80  
          Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser
                          85                  90                  95      
          Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
                      100                 105                 110         
          Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly
                  115                 120                 125             
          Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
                  195                 200                 205             
          Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
                  275                 280                 285             
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
              290                 295                 300                 
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
          305                 310                 315                 320 
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
                          325                 330                 335     
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
                      340                 345                 350         
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                  355                 360                 365             
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
              370                 375                 380                 
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
          385                 390                 395                 400 
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
                          405                 410                 415     
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
                      420                 425                 430         
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  435                 440                 445             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              450                 455                 460                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          465                 470                 475                 480 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          485                 490                 495     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      500                 505                 510         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  515                 520                 525             
          Arg Ile Ser Val Gln Glu Arg Gln
              530                 535     
          <![CDATA[<210> 249]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 249]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 250]]>
          <![CDATA[<211> 529]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 250]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
                      20                  25                  30          
          Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
                  35                  40                  45              
          Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
                  115                 120                 125             
          Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly
                  195                 200                 205             
          Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                      260                 265                 270         
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
                  275                 280                 285             
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
              290                 295                 300                 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
          305                 310                 315                 320 
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                          325                 330                 335     
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                      340                 345                 350         
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
                  355                 360                 365             
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
              370                 375                 380                 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
          385                 390                 395                 400 
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                          405                 410                 415     
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                      420                 425                 430         
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                  435                 440                 445             
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
              450                 455                 460                 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
          465                 470                 475                 480 
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                          485                 490                 495     
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                      500                 505                 510         
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                  515                 520                 525             
          Gln
          <![CDATA[<210> 251]]>
          <![CDATA[<211> 532]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 251]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu
                      260                 265                 270         
          Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu
                  275                 280                 285             
          Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser
              290                 295                 300                 
          Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly
          305                 310                 315                 320 
          Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys
                          325                 330                 335     
          Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu
                      340                 345                 350         
          Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr
                  355                 360                 365             
          Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His
              370                 375                 380                 
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
          385                 390                 395                 400 
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                          405                 410                 415     
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
                      420                 425                 430         
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                  435                 440                 445             
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
              450                 455                 460                 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
          465                 470                 475                 480 
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                          485                 490                 495     
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                      500                 505                 510         
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                  515                 520                 525             
          Gln Glu Arg Gln
              530         
          <![CDATA[<210> 252]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 252]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Glu Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr
                  35                  40                  45              
          Val Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile
              50                  55                  60                  
          Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr
          65                  70                  75                  80  
          Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile
                          85                  90                  95      
          Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val
                      100                 105                 110         
          Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn
                  115                 120                 125             
          Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 253]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 253]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
                  35                  40                  45              
          Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro
              50                  55                  60                  
          Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp
                  115                 120                 125             
          Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser
                  195                 200                 205             
          Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
                  275                 280                 285             
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
              290                 295                 300                 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
          305                 310                 315                 320 
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                          325                 330                 335     
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                      340                 345                 350         
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  355                 360                 365             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              370                 375                 380                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          385                 390                 395                 400 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          405                 410                 415     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      420                 425                 430         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 254]]>
          <![CDATA[<211> 460]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 254]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Glu Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val
                  35                  40                  45              
          Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg
              50                  55                  60                  
          Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser
          65                  70                  75                  80  
          Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser
                          85                  90                  95      
          Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
                      100                 105                 110         
          Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly
                  115                 120                 125             
          Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
                  195                 200                 205             
          Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro
                  275                 280                 285             
          Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
              290                 295                 300                 
          Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
          305                 310                 315                 320 
          Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
                          325                 330                 335     
          Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
                      340                 345                 350         
          Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  355                 360                 365             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              370                 375                 380                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          385                 390                 395                 400 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          405                 410                 415     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      420                 425                 430         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  435                 440                 445             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460 
          <![CDATA[<210> 255]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 255]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 256]]>
          <![CDATA[<211> 453]]>
          <![CDATA[<21]]>2> PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt; 人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt; ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 256]]&gt;
          <br/><![CDATA[Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
                      20                  25                  30          
          Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
                  35                  40                  45              
          Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
                  115                 120                 125             
          Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly
                  195                 200                 205             
          Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                      260                 265                 270         
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
                  275                 280                 285             
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
              290                 295                 300                 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
          305                 310                 315                 320 
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                          325                 330                 335     
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                      340                 345                 350         
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                  355                 360                 365             
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
              370                 375                 380                 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
          385                 390                 395                 400 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          405                 410                 415     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      420                 425                 430         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  435                 440                 445             
          Val Gln Glu Arg Gln
              450             
          <![CDATA[<210> 257]]>
          <![CDATA[<211> 456]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 257]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val
                      260                 265                 270         
          Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro
                  275                 280                 285             
          Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro
              290                 295                 300                 
          Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu
          305                 310                 315                 320 
          Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys
                          325                 330                 335     
          Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg
                      340                 345                 350         
          Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                  355                 360                 365             
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
              370                 375                 380                 
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
          385                 390                 395                 400 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          405                 410                 415     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      420                 425                 430         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  435                 440                 445             
          Arg Ile Ser Val Gln Glu Arg Gln
              450                 455     
          <![CDATA[<210> 258]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 258]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Glu Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr
                  35                  40                  45              
          Val Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile
              50                  55                  60                  
          Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr
          65                  70                  75                  80  
          Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile
                          85                  90                  95      
          Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val
                      100                 105                 110         
          Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn
                  115                 120                 125             
          Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 259]]>
          <![CDATA[<211> 401]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 259]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
                  35                  40                  45              
          Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro
              50                  55                  60                  
          Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp
                  115                 120                 125             
          Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser
                  195                 200                 205             
          Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                      260                 265                 270         
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                  275                 280                 285             
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
              290                 295                 300                 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
          305                 310                 315                 320 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                          325                 330                 335     
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      340                 345                 350         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  355                 360                 365             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              370                 375                 380                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          385                 390                 395                 400 
          Gln
          <![CDATA[<210> 260]]>
          <![CDATA[<211> 404]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 260]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Glu Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val
                  35                  40                  45              
          Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg
              50                  55                  60                  
          Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser
          65                  70                  75                  80  
          Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser
                          85                  90                  95      
          Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
                      100                 105                 110         
          Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly
                  115                 120                 125             
          Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
                  195                 200                 205             
          Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
                  275                 280                 285             
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
              290                 295                 300                 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
          305                 310                 315                 320 
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                          325                 330                 335     
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                      340                 345                 350         
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                  355                 360                 365             
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
              370                 375                 380                 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
          385                 390                 395                 400 
          Gln Glu Arg Gln
          <![CDATA[<210> 261]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 261]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 262]]>
          <![CDATA[<211> 397]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 262]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
                      20                  25                  30          
          Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
                  35                  40                  45              
          Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
                  115                 120                 125             
          Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly
                  195                 200                 205             
          Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                      260                 265                 270         
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                  275                 280                 285             
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
              290                 295                 300                 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
          305                 310                 315                 320 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                          325                 330                 335     
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                      340                 345                 350         
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                  355                 360                 365             
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
              370                 375                 380                 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395         
          <![CDATA[<210> 263]]>
          <![CDATA[<211> 400]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 263]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp
                      260                 265                 270         
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                  275                 280                 285             
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
              290                 295                 300                 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
          305                 310                 315                 320 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                          325                 330                 335     
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                      340                 345                 350         
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                  355                 360                 365             
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
              370                 375                 380                 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          385                 390                 395                 400 
          <![CDATA[<210> 264]]>
          <![CDATA[<211> 545]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 264]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg
              50                  55                  60                  
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala
          65                  70                  75                  80  
          Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr
                          85                  90                  95      
          Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
                      100                 105                 110         
          Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala
                  115                 120                 125             
          Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu
              130                 135                 140                 
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
          145                 150                 155                 160 
          Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                          165                 170                 175     
          Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg
                      180                 185                 190         
          Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala
                          245                 250                 255     
          Tyr Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val
                      260                 265                 270         
          Glu Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                  275                 280                 285             
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
              290                 295                 300                 
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
          305                 310                 315                 320 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
                          325                 330                 335     
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                      340                 345                 350         
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                  355                 360                 365             
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
              370                 375                 380                 
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
          385                 390                 395                 400 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
                          405                 410                 415     
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                      420                 425                 430         
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                  435                 440                 445             
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
              450                 455                 460                 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
          465                 470                 475                 480 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          485                 490                 495     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      500                 505                 510         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  515                 520                 525             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              530                 535                 540                 
          Gln
          545 
          <![CDATA[<210> 265]]>
          <![CDATA[<211> 541]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 265]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser
          65                  70                  75                  80  
          Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp
                          85                  90                  95      
          Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser
                  115                 120                 125             
          Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr
                      180                 185                 190         
          Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser
                          245                 250                 255     
          Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu
                  275                 280                 285             
          Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn
              290                 295                 300                 
          Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser
          305                 310                 315                 320 
          Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln
                          325                 330                 335     
          Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu
                      340                 345                 350         
          Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile
                  355                 360                 365             
          Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn
              370                 375                 380                 
          Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys
          385                 390                 395                 400 
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
                          405                 410                 415     
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                      420                 425                 430         
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  435                 440                 445             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              450                 455                 460                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          465                 470                 475                 480 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          485                 490                 495     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      500                 505                 510         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  515                 520                 525             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540     
          <![CDATA[<210> 266]]>
          <![CDATA[<211> 544]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 266]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly
          65                  70                  75                  80  
          Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile
                          85                  90                  95      
          Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
                      100                 105                 110         
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn
                  115                 120                 125             
          Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
                          165                 170                 175     
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile
                      180                 185                 190         
          Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr
                          245                 250                 255     
          Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu
                      260                 265                 270         
          Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser
                  275                 280                 285             
          Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr
              290                 295                 300                 
          Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly
          305                 310                 315                 320 
          Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln
                          325                 330                 335     
          Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu
                      340                 345                 350         
          Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln
                  355                 360                 365             
          Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr
              370                 375                 380                 
          Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys
          385                 390                 395                 400 
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
                          405                 410                 415     
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                      420                 425                 430         
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
                  435                 440                 445             
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
              450                 455                 460                 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
          465                 470                 475                 480 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                          485                 490                 495     
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                      500                 505                 510         
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                  515                 520                 525             
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540                 
          <![CDATA[<210> 267]]>
          <![CDATA[<211> 540]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 267]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  435                 440                 445             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              450                 455                 460                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          465                 470                 475                 480 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          485                 490                 495     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      500                 505                 510         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  515                 520                 525             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540 
          <![CDATA[<210> 268]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 268]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe
                  35                  40                  45              
          Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
              50                  55                  60                  
          Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala
          65                  70                  75                  80  
          Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                          85                  90                  95      
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu
                  115                 120                 125             
          Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser
                  195                 200                 205             
          Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His
                          245                 250                 255     
          Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 269]]>
          <![CDATA[<211> 540]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> ]]>人工序列
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 269]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  435                 440                 445             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              450                 455                 460                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          465                 470                 475                 480 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          485                 490                 495     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      500                 505                 510         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  515                 520                 525             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540 
          <![CDATA[<210> 270]]>
          <![CDATA[<211> 469]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 270]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg
              50                  55                  60                  
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala
          65                  70                  75                  80  
          Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr
                          85                  90                  95      
          Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
                      100                 105                 110         
          Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala
                  115                 120                 125             
          Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu
              130                 135                 140                 
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
          145                 150                 155                 160 
          Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                          165                 170                 175     
          Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg
                      180                 185                 190         
          Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala
                          245                 250                 255     
          Tyr Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val
                      260                 265                 270         
          Glu Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                  275                 280                 285             
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
              290                 295                 300                 
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
          305                 310                 315                 320 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
                          325                 330                 335     
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                      340                 345                 350         
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                  355                 360                 365             
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
              370                 375                 380                 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
          385                 390                 395                 400 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                          405                 410                 415     
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                      420                 425                 430         
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                  435                 440                 445             
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
              450                 455                 460                 
          Val Gln Glu Arg Gln
          465                 
          <![CDATA[<210> 271]]>
          <![CDATA[<211> 465]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 271]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser
          65                  70                  75                  80  
          Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp
                          85                  90                  95      
          Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser
                  115                 120                 125             
          Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr
                      180                 185                 190         
          Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser
                          245                 250                 255     
          Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys
                  275                 280                 285             
          Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
              290                 295                 300                 
          Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala
          305                 310                 315                 320 
          Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
                          325                 330                 335     
          Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
                      340                 345                 350         
          Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg
                  355                 360                 365             
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
              370                 375                 380                 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
          385                 390                 395                 400 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          405                 410                 415     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      420                 425                 430         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  435                 440                 445             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              450                 455                 460                 
          Gln
          465 
          <![CDATA[<210> 272]]>
          <![CDATA[<211> 468]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 272]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly
          65                  70                  75                  80  
          Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile
                          85                  90                  95      
          Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
                      100                 105                 110         
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn
                  115                 120                 125             
          Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
                          165                 170                 175     
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile
                      180                 185                 190         
          Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr
                          245                 250                 255     
          Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu
                      260                 265                 270         
          Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu
                  275                 280                 285             
          Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala
              290                 295                 300                 
          Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
          305                 310                 315                 320 
          Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys
                          325                 330                 335     
          Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
                      340                 345                 350         
          Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys
                  355                 360                 365             
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
              370                 375                 380                 
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
          385                 390                 395                 400 
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                          405                 410                 415     
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                      420                 425                 430         
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                  435                 440                 445             
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
              450                 455                 460                 
          Gln Glu Arg Gln
          465             
          <![CDATA[<210> 273]]>
          <![CDATA[<211> 464]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 273]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu
                  355                 360                 365             
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
              370                 375                 380                 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
          385                 390                 395                 400 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                          405                 410                 415     
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                      420                 425                 430         
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                  435                 440                 445             
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460                 
          <![CDATA[<210> 274]]>
          <![CDATA[<211> 461]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 274]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe
                  35                  40                  45              
          Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
              50                  55                  60                  
          Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala
          65                  70                  75                  80  
          Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                          85                  90                  95      
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu
                  115                 120                 125             
          Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser
                  195                 200                 205             
          Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His
                          245                 250                 255     
          Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr
                  275                 280                 285             
          Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro
              290                 295                 300                 
          Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val
          305                 310                 315                 320 
          His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro
                          325                 330                 335     
          Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu
                      340                 345                 350         
          Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                  355                 360                 365             
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
              370                 375                 380                 
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
          385                 390                 395                 400 
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                          405                 410                 415     
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                      420                 425                 430         
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                  435                 440                 445             
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460     
          <![CDATA[<210> 275]]>
          <![CDATA[<21]]>1> 464]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt; PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt; 人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt; ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 275]]&gt;
          <br/><![CDATA[Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu
                  355                 360                 365             
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
              370                 375                 380                 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
          385                 390                 395                 400 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                          405                 410                 415     
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                      420                 425                 430         
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                  435                 440                 445             
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460                 
          <![CDATA[<210> 276]]>
          <![CDATA[<211> 413]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 276]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg
              50                  55                  60                  
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala
          65                  70                  75                  80  
          Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr
                          85                  90                  95      
          Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
                      100                 105                 110         
          Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala
                  115                 120                 125             
          Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu
              130                 135                 140                 
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
          145                 150                 155                 160 
          Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                          165                 170                 175     
          Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg
                      180                 185                 190         
          Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala
                          245                 250                 255     
          Tyr Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val
                      260                 265                 270         
          Glu Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                  275                 280                 285             
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
              290                 295                 300                 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
          305                 310                 315                 320 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                          325                 330                 335     
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                      340                 345                 350         
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                  355                 360                 365             
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
              370                 375                 380                 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
          385                 390                 395                 400 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410             
          <![CDATA[<210> 277]]>
          <![CDATA[<211> 409]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 277]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser
          65                  70                  75                  80  
          Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp
                          85                  90                  95      
          Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser
                  115                 120                 125             
          Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr
                      180                 185                 190         
          Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser
                          245                 250                 255     
          Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly
                  275                 280                 285             
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
              290                 295                 300                 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
          305                 310                 315                 320 
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                          325                 330                 335     
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                      340                 345                 350         
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                  355                 360                 365             
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
              370                 375                 380                 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
          385                 390                 395                 400 
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 
          <![CDATA[<210> 278]]>
          <![CDATA[<211> 412]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 278]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly
          65                  70                  75                  80  
          Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile
                          85                  90                  95      
          Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
                      100                 105                 110         
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn
                  115                 120                 125             
          Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
                          165                 170                 175     
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile
                      180                 185                 190         
          Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr
                          245                 250                 255     
          Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu
                      260                 265                 270         
          Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val
                  275                 280                 285             
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
              290                 295                 300                 
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
          305                 310                 315                 320 
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                          325                 330                 335     
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                      340                 345                 350         
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                  355                 360                 365             
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
              370                 375                 380                 
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
          385                 390                 395                 400 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410         
          <![CDATA[<210> 279]]>
          <![CDATA[<211> 408]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 279]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val
                  275                 280                 285             
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
              290                 295                 300                 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
          305                 310                 315                 320 
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                          325                 330                 335     
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                      340                 345                 350         
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                  355                 360                 365             
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
              370                 375                 380                 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
          385                 390                 395                 400 
          Arg Ile Ser Val Gln Glu Arg Gln
                          405             
          <![CDATA[<210> 280]]>
          <![CDATA[<211> 405]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 280]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe
                  35                  40                  45              
          Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
              50                  55                  60                  
          Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala
          65                  70                  75                  80  
          Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                          85                  90                  95      
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu
                  115                 120                 125             
          Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser
                  195                 200                 205             
          Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His
                          245                 250                 255     
          Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                  275                 280                 285             
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
              290                 295                 300                 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
          305                 310                 315                 320 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                          325                 330                 335     
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                      340                 345                 350         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  355                 360                 365             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              370                 375                 380                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          385                 390                 395                 400 
          Val Gln Glu Arg Gln
                          405 
          <![CDATA[<210> 281]]>
          <![CDATA[<211> 408]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 281]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly Gly Val
                  275                 280                 285             
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
              290                 295                 300                 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
          305                 310                 315                 320 
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                          325                 330                 335     
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                      340                 345                 350         
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                  355                 360                 365             
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
              370                 375                 380                 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
          385                 390                 395                 400 
          Arg Ile Ser Val Gln Glu Arg Gln
                          405             
          <![CDATA[<210> 282]]>
          <![CDATA[<211> 550]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 282]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala
                  35                  40                  45              
          Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile
              50                  55                  60                  
          Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr
          65                  70                  75                  80  
          Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met
                          85                  90                  95      
          Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn
                      100                 105                 110         
          Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met
                  115                 120                 125             
          Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn
                      180                 185                 190         
          Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro
                  195                 200                 205             
          Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly
              210                 215                 220                 
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn
          225                 230                 235                 240 
          Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp
                          245                 250                 255     
          Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly
                      260                 265                 270         
          Thr Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly
                  275                 280                 285             
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
              290                 295                 300                 
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
          305                 310                 315                 320 
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
                          325                 330                 335     
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
                      340                 345                 350         
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
                  355                 360                 365             
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
              370                 375                 380                 
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
          385                 390                 395                 400 
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                          405                 410                 415     
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
                      420                 425                 430         
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                  435                 440                 445             
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
              450                 455                 460                 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
          465                 470                 475                 480 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                          485                 490                 495     
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                      500                 505                 510         
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                  515                 520                 525             
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
              530                 535                 540                 
          Ser Val Gln Glu Arg Gln
          545                 550 
          <![CDATA[<210> 283]]>
          <![CDATA[<211> 546]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 283]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp
                  35                  40                  45              
          Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro
              50                  55                  60                  
          Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp
          65                  70                  75                  80  
          Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro
                          85                  90                  95      
          Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr
                  115                 120                 125             
          Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
          145                 150                 155                 160 
          Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser
                          165                 170                 175     
          Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr
                      180                 185                 190         
          Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu
                  195                 200                 205             
          Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu
          225                 230                 235                 240 
          Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met
                          245                 250                 255     
          Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr
                      260                 265                 270         
          Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys
                  275                 280                 285             
          Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys
              290                 295                 300                 
          Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His
          305                 310                 315                 320 
          Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr
                          325                 330                 335     
          Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly
                      340                 345                 350         
          Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val
                  355                 360                 365             
          Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro
              370                 375                 380                 
          Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys
          385                 390                 395                 400 
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
                          405                 410                 415     
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                      420                 425                 430         
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                  435                 440                 445             
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
              450                 455                 460                 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
          465                 470                 475                 480 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                          485                 490                 495     
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                      500                 505                 510         
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                  515                 520                 525             
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
              530                 535                 540                 
          Arg Gln
          545     
          <![CDATA[<210> 284]]>
          <![CDATA[<211> 549]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 284]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile
                  35                  40                  45              
          Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg
              50                  55                  60                  
          Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg
          65                  70                  75                  80  
          Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser
                          85                  90                  95      
          Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser
                      100                 105                 110         
          Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met
                  115                 120                 125             
          Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro
                          165                 170                 175     
          Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val
                      180                 185                 190         
          Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro
                  195                 200                 205             
          Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser
              210                 215                 220                 
          Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala
          225                 230                 235                 240 
          Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
                          245                 250                 255     
          Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr
                      260                 265                 270         
          Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                  275                 280                 285             
          Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn
              290                 295                 300                 
          Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala
          305                 310                 315                 320 
          Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr
                          325                 330                 335     
          Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn
                      340                 345                 350         
          Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn
                  355                 360                 365             
          Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met
              370                 375                 380                 
          Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile
          385                 390                 395                 400 
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                          405                 410                 415     
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
                      420                 425                 430         
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
                  435                 440                 445             
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
              450                 455                 460                 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
          465                 470                 475                 480 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                          485                 490                 495     
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                      500                 505                 510         
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                  515                 520                 525             
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
              530                 535                 540                 
          Val Gln Glu Arg Gln
          545                 
          <![CDATA[<210> 285]]>
          <![CDATA[<211> 545]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 285]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                  275                 280                 285             
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
              290                 295                 300                 
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
          305                 310                 315                 320 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
                          325                 330                 335     
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                      340                 345                 350         
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                  355                 360                 365             
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
              370                 375                 380                 
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
          385                 390                 395                 400 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
                          405                 410                 415     
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                      420                 425                 430         
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                  435                 440                 445             
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
              450                 455                 460                 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
          465                 470                 475                 480 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          485                 490                 495     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      500                 505                 510         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  515                 520                 525             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              530                 535                 540                 
          Gln
          545 
          <![CDATA[<210> 286]]>
          <![CDATA[<211> 542]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 286]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser
                      20                  25                  30          
          Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser
                  35                  40                  45              
          Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu
              50                  55                  60                  
          Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr
          65                  70                  75                  80  
          Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys
                          85                  90                  95      
          Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr
                          165                 170                 175     
          Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys
                  195                 200                 205             
          Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly
          225                 230                 235                 240 
          Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser
                          245                 250                 255     
          Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met
                  275                 280                 285             
          Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr
              290                 295                 300                 
          Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp
          305                 310                 315                 320 
          Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu
                          325                 330                 335     
          Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn
                      340                 345                 350         
          Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp
                  355                 360                 365             
          Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp
              370                 375                 380                 
          Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu
          385                 390                 395                 400 
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
                          405                 410                 415     
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                      420                 425                 430         
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                  435                 440                 445             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              450                 455                 460                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          465                 470                 475                 480 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          485                 490                 495     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      500                 505                 510         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  515                 520                 525             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540         
          <![CDATA[<210> 287]]>
          <![CDATA[<211> 545]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 287]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln
                  275                 280                 285             
          Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys
              290                 295                 300                 
          Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys
          305                 310                 315                 320 
          Gly Leu Asp Ser Ala Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser
                          325                 330                 335     
          Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys
                      340                 345                 350         
          Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn
                  355                 360                 365             
          Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro
              370                 375                 380                 
          Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly
          385                 390                 395                 400 
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
                          405                 410                 415     
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
                      420                 425                 430         
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                  435                 440                 445             
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
              450                 455                 460                 
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
          465                 470                 475                 480 
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          485                 490                 495     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      500                 505                 510         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  515                 520                 525             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              530                 535                 540                 
          Gln
          545 
          <![CDATA[<210> 288]]>
          <![CDATA[<211> 474]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 288]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala
                  35                  40                  45              
          Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile
              50                  55                  60                  
          Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr
          65                  70                  75                  80  
          Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met
                          85                  90                  95      
          Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn
                      100                 105                 110         
          Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met
                  115                 120                 125             
          Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn
                      180                 185                 190         
          Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro
                  195                 200                 205             
          Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly
              210                 215                 220                 
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn
          225                 230                 235                 240 
          Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp
                          245                 250                 255     
          Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly
                      260                 265                 270         
          Thr Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly
                  275                 280                 285             
          Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro
              290                 295                 300                 
          Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
          305                 310                 315                 320 
          Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
                          325                 330                 335     
          Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
                      340                 345                 350         
          Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn
                  355                 360                 365             
          His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
              370                 375                 380                 
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
          385                 390                 395                 400 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                          405                 410                 415     
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                      420                 425                 430         
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                  435                 440                 445             
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
              450                 455                 460                 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          465                 470                 
          <![CDATA[<210> 289]]>
          <![CDATA[<211> 470]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 289]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp
                  35                  40                  45              
          Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro
              50                  55                  60                  
          Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp
          65                  70                  75                  80  
          Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro
                          85                  90                  95      
          Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr
                  115                 120                 125             
          Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
          145                 150                 155                 160 
          Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser
                          165                 170                 175     
          Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr
                      180                 185                 190         
          Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu
                  195                 200                 205             
          Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu
          225                 230                 235                 240 
          Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met
                          245                 250                 255     
          Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr
                      260                 265                 270         
          Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val
                  275                 280                 285             
          Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr
              290                 295                 300                 
          Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala
          305                 310                 315                 320 
          Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe
                          325                 330                 335     
          Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val
                      340                 345                 350         
          Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg
                  355                 360                 365             
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
              370                 375                 380                 
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
          385                 390                 395                 400 
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                          405                 410                 415     
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                      420                 425                 430         
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                  435                 440                 445             
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
              450                 455                 460                 
          Ser Val Gln Glu Arg Gln
          465                 470 
          <![CDATA[<210> 290]]>
          <![CDATA[<211> 473]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 290]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile
                  35                  40                  45              
          Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg
              50                  55                  60                  
          Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg
          65                  70                  75                  80  
          Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser
                          85                  90                  95      
          Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser
                      100                 105                 110         
          Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met
                  115                 120                 125             
          Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro
                          165                 170                 175     
          Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val
                      180                 185                 190         
          Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro
                  195                 200                 205             
          Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser
              210                 215                 220                 
          Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala
          225                 230                 235                 240 
          Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
                          245                 250                 255     
          Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr
                      260                 265                 270         
          Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                  275                 280                 285             
          Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
              290                 295                 300                 
          Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
          305                 310                 315                 320 
          Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
                          325                 330                 335     
          Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
                      340                 345                 350         
          Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
                  355                 360                 365             
          Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
              370                 375                 380                 
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
          385                 390                 395                 400 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                          405                 410                 415     
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                      420                 425                 430         
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                  435                 440                 445             
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
              450                 455                 460                 
          Ser Arg Ile Ser Val Gln Glu Arg Gln
          465                 470             
          <![CDATA[<210> 291]]>
          <![CDATA[<211> 469]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 291]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                  275                 280                 285             
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
              290                 295                 300                 
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
          305                 310                 315                 320 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
                          325                 330                 335     
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                      340                 345                 350         
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                  355                 360                 365             
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
              370                 375                 380                 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
          385                 390                 395                 400 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                          405                 410                 415     
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                      420                 425                 430         
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                  435                 440                 445             
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
              450                 455                 460                 
          Val Gln Glu Arg Gln
          465                 
          <![CDATA[<210> 292]]>
          <![CDATA[<211> 466]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 292]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser
                      20                  25                  30          
          Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser
                  35                  40                  45              
          Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu
              50                  55                  60                  
          Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr
          65                  70                  75                  80  
          Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys
                          85                  90                  95      
          Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr
                          165                 170                 175     
          Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys
                  195                 200                 205             
          Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly
          225                 230                 235                 240 
          Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser
                          245                 250                 255     
          Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala
                  275                 280                 285             
          Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
              290                 295                 300                 
          Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
          305                 310                 315                 320 
          Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
                          325                 330                 335     
          Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
                      340                 345                 350         
          Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser
                  355                 360                 365             
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
              370                 375                 380                 
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
          385                 390                 395                 400 
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                          405                 410                 415     
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                      420                 425                 430         
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                  435                 440                 445             
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
              450                 455                 460                 
          Arg Gln
          465     
          <![CDATA[<210> 293]]>
          <![CDATA[<211> 469]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 293]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe
                  275                 280                 285             
          Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro
              290                 295                 300                 
          Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys
          305                 310                 315                 320 
          Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala
                          325                 330                 335     
          Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu
                      340                 345                 350         
          Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser
                  355                 360                 365             
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
              370                 375                 380                 
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
          385                 390                 395                 400 
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                          405                 410                 415     
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                      420                 425                 430         
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                  435                 440                 445             
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
              450                 455                 460                 
          Val Gln Glu Arg Gln
          465                 
          <![CDATA[<210> 294]]>
          <![CDATA[<211> 418]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<22]]>3> 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 294]]&gt;
          <br/><![CDATA[Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala
                  35                  40                  45              
          Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile
              50                  55                  60                  
          Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr
          65                  70                  75                  80  
          Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met
                          85                  90                  95      
          Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn
                      100                 105                 110         
          Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met
                  115                 120                 125             
          Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn
                      180                 185                 190         
          Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro
                  195                 200                 205             
          Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly
              210                 215                 220                 
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn
          225                 230                 235                 240 
          Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp
                          245                 250                 255     
          Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly
                      260                 265                 270         
          Thr Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly
                  275                 280                 285             
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
              290                 295                 300                 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
          305                 310                 315                 320 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                          325                 330                 335     
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                      340                 345                 350         
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                  355                 360                 365             
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
              370                 375                 380                 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
          385                 390                 395                 400 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                          405                 410                 415     
          Arg Gln
          <![CDATA[<210> 295]]>
          <![CDATA[<211> 414]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 295]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp
                  35                  40                  45              
          Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro
              50                  55                  60                  
          Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp
          65                  70                  75                  80  
          Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro
                          85                  90                  95      
          Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr
                  115                 120                 125             
          Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
          145                 150                 155                 160 
          Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser
                          165                 170                 175     
          Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr
                      180                 185                 190         
          Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu
                  195                 200                 205             
          Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu
          225                 230                 235                 240 
          Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met
                          245                 250                 255     
          Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr
                      260                 265                 270         
          Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu
                  275                 280                 285             
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
              290                 295                 300                 
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
          305                 310                 315                 320 
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
                          325                 330                 335     
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                      340                 345                 350         
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                  355                 360                 365             
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
              370                 375                 380                 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
          385                 390                 395                 400 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410                 
          <![CDATA[<210> 296]]>
          <![CDATA[<211> 417]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 296]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile
                  35                  40                  45              
          Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg
              50                  55                  60                  
          Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg
          65                  70                  75                  80  
          Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser
                          85                  90                  95      
          Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser
                      100                 105                 110         
          Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met
                  115                 120                 125             
          Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro
                          165                 170                 175     
          Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val
                      180                 185                 190         
          Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro
                  195                 200                 205             
          Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser
              210                 215                 220                 
          Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala
          225                 230                 235                 240 
          Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
                          245                 250                 255     
          Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr
                      260                 265                 270         
          Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe
                  275                 280                 285             
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
              290                 295                 300                 
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
          305                 310                 315                 320 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                          325                 330                 335     
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                      340                 345                 350         
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                  355                 360                 365             
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
              370                 375                 380                 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
          385                 390                 395                 400 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                          405                 410                 415     
          Gln
          <![CDATA[<210> 297]]>
          <![CDATA[<211> 413]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 297]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                  275                 280                 285             
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
              290                 295                 300                 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
          305                 310                 315                 320 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                          325                 330                 335     
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                      340                 345                 350         
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                  355                 360                 365             
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
              370                 375                 380                 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
          385                 390                 395                 400 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410             
          <![CDATA[<210> 298]]>
          <![CDATA[<211> 410]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 298]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser
                      20                  25                  30          
          Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser
                  35                  40                  45              
          Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu
              50                  55                  60                  
          Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr
          65                  70                  75                  80  
          Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys
                          85                  90                  95      
          Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr
                          165                 170                 175     
          Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys
                  195                 200                 205             
          Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly
          225                 230                 235                 240 
          Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser
                          245                 250                 255     
          Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val Val Val Gly
                  275                 280                 285             
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
              290                 295                 300                 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
          305                 310                 315                 320 
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                          325                 330                 335     
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                      340                 345                 350         
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                  355                 360                 365             
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
              370                 375                 380                 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
          385                 390                 395                 400 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410 
          <![CDATA[<210> 299]]>
          <![CDATA[<211> 413]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 299]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Phe Trp Val Leu Val
                  275                 280                 285             
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
              290                 295                 300                 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
          305                 310                 315                 320 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                          325                 330                 335     
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                      340                 345                 350         
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                  355                 360                 365             
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
              370                 375                 380                 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
          385                 390                 395                 400 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410             
          <![CDATA[<210> 300]]>
          <![CDATA[<211> 425]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 300]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn
          65                  70                  75                  80  
          Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly
                  115                 120                 125             
          Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu
                          165                 170                 175     
          Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp
                  195                 200                 205             
          Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp
          225                 230                 235                 240 
          Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe
                          245                 250                 255     
          Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
                  275                 280                 285             
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
              290                 295                 300                 
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
          305                 310                 315                 320 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                          325                 330                 335     
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                      340                 345                 350         
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                  355                 360                 365             
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
              370                 375                 380                 
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
          385                 390                 395                 400 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                          405                 410                 415     
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425 
          <![CDATA[<210> 301]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 301]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys
              50                  55                  60                  
          Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser
          65                  70                  75                  80  
          Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser
                          85                  90                  95      
          Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser
                      100                 105                 110         
          Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr
          145                 150                 155                 160 
          Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met
                          165                 170                 175     
          Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu
                  195                 200                 205             
          Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser
              210                 215                 220                 
          Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 302]]>
          <![CDATA[<211> 424]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 302]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser
              50                  55                  60                  
          His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly
          65                  70                  75                  80  
          Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val
                          85                  90                  95      
          Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser
                      100                 105                 110         
          Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg
                  115                 120                 125             
          Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys
                          165                 170                 175     
          Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr
                  195                 200                 205             
          Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser
              210                 215                 220                 
          Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp
          225                 230                 235                 240 
          Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly
                          245                 250                 255     
          Ala Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser
                      260                 265                 270         
          Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  275                 280                 285             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              290                 295                 300                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          305                 310                 315                 320 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          325                 330                 335     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      340                 345                 350         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                  355                 360                 365             
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
              370                 375                 380                 
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
          385                 390                 395                 400 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                          405                 410                 415     
          Arg Ile Ser Val Gln Glu Arg Gln
                      420                 
          <![CDATA[<210> 303]]>
          <![CDATA[<211> 420]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 303]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His
                      260                 265                 270         
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
                  275                 280                 285             
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
              290                 295                 300                 
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
          305                 310                 315                 320 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                          325                 330                 335     
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                      340                 345                 350         
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                  355                 360                 365             
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
              370                 375                 380                 
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
          385                 390                 395                 400 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                          405                 410                 415     
          Gln Glu Arg Gln
                      420 
          <![CDATA[<210> 304]]>
          <![CDATA[<211> 417]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 304]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly
                  35                  40                  45              
          Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp
              50                  55                  60                  
          Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys
          65                  70                  75                  80  
          Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala
                          85                  90                  95      
          Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
                      100                 105                 110         
          Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala
          145                 150                 155                 160 
          Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala
                          165                 170                 175     
          Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr
                      180                 185                 190         
          Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val
                  195                 200                 205             
          Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr
              210                 215                 220                 
          Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln
          225                 230                 235                 240 
          Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly
                      260                 265                 270         
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
                  275                 280                 285             
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
              290                 295                 300                 
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
          305                 310                 315                 320 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                          325                 330                 335     
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                      340                 345                 350         
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                  355                 360                 365             
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
              370                 375                 380                 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
          385                 390                 395                 400 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                          405                 410                 415     
          Gln
          <![CDATA[<210> 305]]>
          <![CDATA[<211> 420]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 305]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser
              50                  55                  60                  
          Leu Glu Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr
          65                  70                  75                  80  
          Asn Gln Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser
                          85                  90                  95      
          Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala
                      100                 105                 110         
          Val Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln
          145                 150                 155                 160 
          Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr
                          165                 170                 175     
          Cys Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys
                      180                 185                 190         
          Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala
                  195                 200                 205             
          Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr
              210                 215                 220                 
          Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr
          225                 230                 235                 240 
          Cys Gln Gln Trp Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys
                          245                 250                 255     
          Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His
                      260                 265                 270         
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
                  275                 280                 285             
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
              290                 295                 300                 
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
          305                 310                 315                 320 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                          325                 330                 335     
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                      340                 345                 350         
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                  355                 360                 365             
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
              370                 375                 380                 
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
          385                 390                 395                 400 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                          405                 410                 415     
          Gln Glu Arg Gln
                      420 
          <![CDATA[<210> 306]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 306]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser
          65                  70                  75                  80  
          Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr
                          85                  90                  95      
          Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg
                      100                 105                 110         
          Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp
                  115                 120                 125             
          Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile
                  195                 200                 205             
          Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 307]]>
          <![CDATA[<211> 417]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 307]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
                  35                  40                  45              
          Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn
          65                  70                  75                  80  
          Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser
                          85                  90                  95      
          Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly
                  195                 200                 205             
          Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu
          225                 230                 235                 240 
          Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile
                          245                 250                 255     
          Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly
                      260                 265                 270         
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
                  275                 280                 285             
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
              290                 295                 300                 
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
          305                 310                 315                 320 
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                          325                 330                 335     
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                      340                 345                 350         
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                  355                 360                 365             
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
              370                 375                 380                 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
          385                 390                 395                 400 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                          405                 410                 415     
          Gln
          <![CDATA[<210> 308]]>
          <![CDATA[<211> 420]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 308]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Glu Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala
                  35                  40                  45              
          Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly
          65                  70                  75                  80  
          Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg
                          85                  90                  95      
          Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser
                      100                 105                 110         
          Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr
                  115                 120                 125             
          Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu
                  195                 200                 205             
          Gln Asn Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Leu Gln Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys
                          245                 250                 255     
          Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His
                      260                 265                 270         
          Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser
                  275                 280                 285             
          Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr
              290                 295                 300                 
          Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys
          305                 310                 315                 320 
          Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg
                          325                 330                 335     
          Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp
                      340                 345                 350         
          Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                  355                 360                 365             
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
              370                 375                 380                 
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
          385                 390                 395                 400 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                          405                 410                 415     
          Gln Glu Arg Gln
                      420 
          <![CDATA[<210> 309]]>
          <![CDATA[<211> 416]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 309]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys
                      260                 265                 270         
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
                  275                 280                 285             
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
              290                 295                 300                 
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
          305                 310                 315                 320 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                          325                 330                 335     
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                      340                 345                 350         
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                  355                 360                 365             
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
              370                 375                 380                 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
          385                 390                 395                 400 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410                 415     
          <![CDATA[<210> 310]]>
          <![CDATA[<211> 413]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 310]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly
                      20                  25                  30          
          Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp
                  35                  40                  45              
          Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys
          65                  70                  75                  80  
          Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala
                          85                  90                  95      
          Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr
                      100                 105                 110         
          Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
                  115                 120                 125             
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
              130                 135                 140                 
          Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
          145                 150                 155                 160 
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile
                          165                 170                 175     
          Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                      180                 185                 190         
          Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg
                  195                 200                 205             
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
              210                 215                 220                 
          Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr
          225                 230                 235                 240 
          Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Ala Ala Ala
                          245                 250                 255     
          Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys
                      260                 265                 270         
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
                  275                 280                 285             
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
              290                 295                 300                 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
          305                 310                 315                 320 
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                          325                 330                 335     
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                      340                 345                 350         
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                  355                 360                 365             
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
              370                 375                 380                 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
          385                 390                 395                 400 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410             
          <![CDATA[<210> 311]]>
          <![CDATA[<211> 416]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 311]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu
                      20                  25                  30          
          Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
                  35                  40                  45              
          Phe Thr Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile
                          85                  90                  95      
          Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly
                  115                 120                 125             
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser
          145                 150                 155                 160 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
                          165                 170                 175     
          Gln Ser Ile Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys
                      180                 185                 190         
          Ala Pro Lys Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val
                  195                 200                 205             
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
              210                 215                 220                 
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
          225                 230                 235                 240 
          Thr Tyr Thr Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
                          245                 250                 255     
          Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys
                      260                 265                 270         
          His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp
                  275                 280                 285             
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
              290                 295                 300                 
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
          305                 310                 315                 320 
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                          325                 330                 335     
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
                      340                 345                 350         
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                  355                 360                 365             
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
              370                 375                 380                 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
          385                 390                 395                 400 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          405                 410                 415     
          <![CDATA[<210> 312]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 312]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Val Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly
          65                  70                  75                  80  
          Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn
                          85                  90                  95      
          Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser
                      100                 105                 110         
          Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp
                  115                 120                 125             
          Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu
                      180                 185                 190         
          Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 313]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 313]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
                      20                  25                  30          
          Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr
                  35                  40                  45              
          Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala
              50                  55                  60                  
          Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr
          65                  70                  75                  80  
          Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr
                          85                  90                  95      
          Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser
                  195                 200                 205             
          Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 314]]>
          <![CDATA[<211> 425]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 314]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Val Gln Ser Gly
                      20                  25                  30          
          Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala
                  35                  40                  45              
          Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala
              50                  55                  60                  
          Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val
          65                  70                  75                  80  
          Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp
                          85                  90                  95      
          Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys
                  195                 200                 205             
          Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
                  275                 280                 285             
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
              290                 295                 300                 
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
          305                 310                 315                 320 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                          325                 330                 335     
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                      340                 345                 350         
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                  355                 360                 365             
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
              370                 375                 380                 
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
          385                 390                 395                 400 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                          405                 410                 415     
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425 
          <![CDATA[<210> 315]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 315]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 316]]>
          <![CDATA[<211> 418]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 316]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly
                      20                  25                  30          
          Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr
                  35                  40                  45              
          Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp
              50                  55                  60                  
          Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe
          65                  70                  75                  80  
          Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr
                          85                  90                  95      
          Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                      100                 105                 110         
          Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys
                  115                 120                 125             
          Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
                  195                 200                 205             
          Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                      260                 265                 270         
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
                  275                 280                 285             
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
              290                 295                 300                 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
          305                 310                 315                 320 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                          325                 330                 335     
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                      340                 345                 350         
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                  355                 360                 365             
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
              370                 375                 380                 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
          385                 390                 395                 400 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                          405                 410                 415     
          Arg Gln
          <![CDATA[<210> 317]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 317]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
                      20                  25                  30          
          Arg Pro Gly Ala Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser
                  35                  40                  45              
          Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly
              50                  55                  60                  
          Leu Glu Trp Met Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala
          65                  70                  75                  80  
          Gln Lys Phe Gln Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn
                          85                  90                  95      
          Thr Val Tyr Met Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val
                  115                 120                 125             
          Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu
                  195                 200                 205             
          Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 318]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 318]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Glu Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr
                  35                  40                  45              
          Val Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile
              50                  55                  60                  
          Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr
          65                  70                  75                  80  
          Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile
                          85                  90                  95      
          Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val
                      100                 105                 110         
          Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn
                  115                 120                 125             
          Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 319]]>
          <![CDATA[<211> 422]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400>]]> 319
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly
                  35                  40                  45              
          Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro
              50                  55                  60                  
          Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr
          65                  70                  75                  80  
          Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr
                          85                  90                  95      
          Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp
                  115                 120                 125             
          Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
          145                 150                 155                 160 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
                          165                 170                 175     
          Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln
                      180                 185                 190         
          Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser
                  195                 200                 205             
          Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr
              210                 215                 220                 
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
          225                 230                 235                 240 
          Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly
                          245                 250                 255     
          Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                      260                 265                 270         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  275                 280                 285             
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
              290                 295                 300                 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
          305                 310                 315                 320 
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                          325                 330                 335     
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                      340                 345                 350         
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
                  355                 360                 365             
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
              370                 375                 380                 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
          385                 390                 395                 400 
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                          405                 410                 415     
          Ser Val Gln Glu Arg Gln
                      420         
          <![CDATA[<210> 320]]>
          <![CDATA[<211> 425]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 320]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Glu Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val
                  35                  40                  45              
          Ser Gly Gly Ser Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg
              50                  55                  60                  
          Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser
          65                  70                  75                  80  
          Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser
                          85                  90                  95      
          Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
                      100                 105                 110         
          Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly
                  115                 120                 125             
          Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg
                          165                 170                 175     
          Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn
                      180                 185                 190         
          Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala
                  195                 200                 205             
          Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly
              210                 215                 220                 
          Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
          225                 230                 235                 240 
          Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe
                          245                 250                 255     
          Gly Gly Gly Thr Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly
                      260                 265                 270         
          Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
                  275                 280                 285             
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
              290                 295                 300                 
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
          305                 310                 315                 320 
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                          325                 330                 335     
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                      340                 345                 350         
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
                  355                 360                 365             
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
              370                 375                 380                 
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
          385                 390                 395                 400 
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                          405                 410                 415     
          Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425 
          <![CDATA[<210> 321]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 321]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 322]]>
          <![CDATA[<211> 418]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 322]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
                      20                  25                  30          
          Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser
                  35                  40                  45              
          Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
              50                  55                  60                  
          Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro
          65                  70                  75                  80  
          Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln
                          85                  90                  95      
          Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr
                      100                 105                 110         
          Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln
                  115                 120                 125             
          Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
          145                 150                 155                 160 
          Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
                          165                 170                 175     
          Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                      180                 185                 190         
          Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly
                  195                 200                 205             
          Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
              210                 215                 220                 
          Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln
          225                 230                 235                 240 
          Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
                          245                 250                 255     
          Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                      260                 265                 270         
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
                  275                 280                 285             
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
              290                 295                 300                 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
          305                 310                 315                 320 
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                          325                 330                 335     
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                      340                 345                 350         
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                  355                 360                 365             
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
              370                 375                 380                 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
          385                 390                 395                 400 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                          405                 410                 415     
          Arg Gln
          <![CDATA[<210> 323]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 323]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser
                  35                  40                  45              
          Val Ser Ser Gly Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn
          65                  70                  75                  80  
          Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser
                          85                  90                  95      
          Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr
                      100                 105                 110         
          Ala Val Tyr Tyr Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile
                  115                 120                 125             
          Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln
          145                 150                 155                 160 
          Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr
                          165                 170                 175     
          Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln
                      180                 185                 190         
          Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu
                  195                 200                 205             
          Gln Ser Gly Val Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp
              210                 215                 220                 
          Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
          225                 230                 235                 240 
          Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr
                          245                 250                 255     
          Lys Val Glu Ile Lys Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile
                      260                 265                 270         
          His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro
                  275                 280                 285             
          Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys
              290                 295                 300                 
          Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser
          305                 310                 315                 320 
          Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
                          325                 330                 335     
          Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
                      340                 345                 350         
          Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 324]]>
          <![CDATA[<211> 434]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 324]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Glu Val Gln Leu Val Glu Ser
                      20                  25                  30          
          Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala
                  35                  40                  45              
          Ala Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg
              50                  55                  60                  
          Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala
          65                  70                  75                  80  
          Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr
                          85                  90                  95      
          Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
                      100                 105                 110         
          Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala
                  115                 120                 125             
          Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu
              130                 135                 140                 
          Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
          145                 150                 155                 160 
          Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser
                          165                 170                 175     
          Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg
                      180                 185                 190         
          Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro
                  195                 200                 205             
          Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
          225                 230                 235                 240 
          Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala
                          245                 250                 255     
          Tyr Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val
                      260                 265                 270         
          Glu Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                  275                 280                 285             
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
              290                 295                 300                 
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
          305                 310                 315                 320 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                          325                 330                 335     
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                      340                 345                 350         
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                  355                 360                 365             
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
              370                 375                 380                 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
          385                 390                 395                 400 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                          405                 410                 415     
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                      420                 425                 430         
          Arg Gln
          <![CDATA[<210> 325]]>
          <![CDATA[<211> 430]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 325]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
                      20                  25                  30          
          Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
                  35                  40                  45              
          Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly
              50                  55                  60                  
          Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser
          65                  70                  75                  80  
          Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp
                          85                  90                  95      
          Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser
                  115                 120                 125             
          Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr
                      180                 185                 190         
          Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile
                  195                 200                 205             
          Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
              210                 215                 220                 
          Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
          225                 230                 235                 240 
          Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser
                          245                 250                 255     
          Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala
                      260                 265                 270         
          Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu
                  275                 280                 285             
          Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu
              290                 295                 300                 
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
          305                 310                 315                 320 
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                          325                 330                 335     
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
                      340                 345                 350         
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                  355                 360                 365             
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
              370                 375                 380                 
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
          385                 390                 395                 400 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                          405                 410                 415     
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430 
          <![CDATA[<210> 326]]>
          <![CDATA[<211> 433]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 326]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Glu Val Gln Leu Val Glu Ser Gly
                      20                  25                  30          
          Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala
                  35                  40                  45              
          Ser Gly Phe Asp Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln
              50                  55                  60                  
          Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly
          65                  70                  75                  80  
          Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile
                          85                  90                  95      
          Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
                      100                 105                 110         
          Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn
                  115                 120                 125             
          Thr Arg Ser Thr Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
                          165                 170                 175     
          Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile
                      180                 185                 190         
          Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys
                  195                 200                 205             
          Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg
              210                 215                 220                 
          Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser
          225                 230                 235                 240 
          Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr
                          245                 250                 255     
          Phe Asp Ser Asn Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu
                      260                 265                 270         
          Ile Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly
                  275                 280                 285             
          Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe
              290                 295                 300                 
          Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu
          305                 310                 315                 320 
          Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg
                          325                 330                 335     
          Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro
                      340                 345                 350         
          Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala
                  355                 360                 365             
          Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
              370                 375                 380                 
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
          385                 390                 395                 400 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                          405                 410                 415     
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                      420                 425                 430         
          Gln
          <![CDATA[<210> 327]]>
          <![CDATA[<211> 429]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 327]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys
                  275                 280                 285             
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
              290                 295                 300                 
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
          305                 310                 315                 320 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                          325                 330                 335     
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                      340                 345                 350         
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                  355                 360                 365             
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
              370                 375                 380                 
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
          385                 390                 395                 400 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                          405                 410                 415     
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 
          <![CDATA[<210> 328]]>
          <![CDATA[<211> 426]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 328]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
                      20                  25                  30          
          Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe
                  35                  40                  45              
          Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
              50                  55                  60                  
          Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala
          65                  70                  75                  80  
          Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
                          85                  90                  95      
          Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
                      100                 105                 110         
          Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu
                  115                 120                 125             
          Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
              130                 135                 140                 
          Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met
          145                 150                 155                 160 
          Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr
                          165                 170                 175     
          Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr
                      180                 185                 190         
          Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser
                  195                 200                 205             
          Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
              210                 215                 220                 
          Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala
          225                 230                 235                 240 
          Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His
                          245                 250                 255     
          Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
                  275                 280                 285             
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
              290                 295                 300                 
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
          305                 310                 315                 320 
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                          325                 330                 335     
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
                      340                 345                 350         
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                  355                 360                 365             
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
              370                 375                 380                 
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
          385                 390                 395                 400 
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                          405                 410                 415     
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425     
          <![CDATA[<210> 329]]>
          <![CDATA[<211> 429]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 329]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val
                      20                  25                  30          
          Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp
                  35                  40                  45              
          Leu Gly Phe Tyr Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys
              50                  55                  60                  
          Gly Leu Glu Trp Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr
          65                  70                  75                  80  
          Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                          85                  90                  95      
          Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                      100                 105                 110         
          Thr Ala Val Tyr Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr
                  115                 120                 125             
          Tyr Tyr Leu Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
          145                 150                 155                 160 
          Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                          165                 170                 175     
          Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu
                      180                 185                 190         
          Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr
                  195                 200                 205             
          Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
          225                 230                 235                 240 
          Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn
                          245                 250                 255     
          Asn Trp His Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His Leu Cys
                  275                 280                 285             
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
              290                 295                 300                 
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
          305                 310                 315                 320 
          Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser
                          325                 330                 335     
          Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His
                      340                 345                 350         
          Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys
                  355                 360                 365             
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
              370                 375                 380                 
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
          385                 390                 395                 400 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
                          405                 410                 415     
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 
          <![CDATA[<210> 330]]>
          <![CDATA[<211> 439]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 330]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala
                  35                  40                  45              
          Ile Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile
              50                  55                  60                  
          Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr
          65                  70                  75                  80  
          Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met
                          85                  90                  95      
          Ser Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn
                      100                 105                 110         
          Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met
                  115                 120                 125             
          Met Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val
              130                 135                 140                 
          Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
          145                 150                 155                 160 
          Gly Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser
                          165                 170                 175     
          Pro Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn
                      180                 185                 190         
          Val Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro
                  195                 200                 205             
          Pro Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly
              210                 215                 220                 
          Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn
          225                 230                 235                 240 
          Ala Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp
                          245                 250                 255     
          Tyr Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly
                      260                 265                 270         
          Thr Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly
                  275                 280                 285             
          Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro
              290                 295                 300                 
          Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu
          305                 310                 315                 320 
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                          325                 330                 335     
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                      340                 345                 350         
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
                  355                 360                 365             
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
              370                 375                 380                 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
          385                 390                 395                 400 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                          405                 410                 415     
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                      420                 425                 430         
          Ile Ser Val Gln Glu Arg Gln
                  435                 
          <![CDATA[<210> 331]]>
          <![CDATA[<211> 435]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 331]]>
          Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
           1               5                  10                  15      
          His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu
                      20                  25                  30          
          Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp
                  35                  40                  45              
          Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro
              50                  55                  60                  
          Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp
          65                  70                  75                  80  
          Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro
                          85                  90                  95      
          Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro
                      100                 105                 110         
          Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr
                  115                 120                 125             
          Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
              130                 135                 140                 
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
          145                 150                 155                 160 
          Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser
                          165                 170                 175     
          Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr
                      180                 185                 190         
          Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu
                  195                 200                 205             
          Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro
              210                 215                 220                 
          Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu
          225                 230                 235                 240 
          Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met
                          245                 250                 255     
          Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr
                      260                 265                 270         
          Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val
                  275                 280                 285             
          Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys
              290                 295                 300                 
          Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
          305                 310                 315                 320 
          Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg
                          325                 330                 335     
          Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro
                      340                 345                 350         
          Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe
                  355                 360                 365             
          Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
              370                 375                 380                 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
          385                 390                 395                 400 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                          405                 410                 415     
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                      420                 425                 430         
          Glu Arg Gln
                  435 
          <![CDATA[<210> 332]]>
          <![CDATA[<211> 438]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 332]]>
          Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
           1               5                  10                  15      
          Val Ser Ser Lys Gly Ala Val Ser Gln Val Gln Leu Gln Gln Ser Gly
                      20                  25                  30          
          Pro Gly Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile
                  35                  40                  45              
          Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg
              50                  55                  60                  
          Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg
          65                  70                  75                  80  
          Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser
                          85                  90                  95      
          Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser
                      100                 105                 110         
          Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met
                  115                 120                 125             
          Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr
              130                 135                 140                 
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
          145                 150                 155                 160 
          Gly Ser Gln Pro Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro
                          165                 170                 175     
          Gly Ala Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val
                      180                 185                 190         
          Gly Pro Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro
                  195                 200                 205             
          Gln Tyr Leu Leu Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser
              210                 215                 220                 
          Gly Val Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala
          225                 230                 235                 240 
          Gly Val Leu Leu Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr
                          245                 250                 255     
          Tyr Cys Met Ile Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr
                      260                 265                 270         
          Gln Leu Thr Val Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile
                  275                 280                 285             
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
              290                 295                 300                 
          Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala
          305                 310                 315                 320 
          Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg
                          325                 330                 335     
          Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
                      340                 345                 350         
          Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
                  355                 360                 365             
          Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr
              370                 375                 380                 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
          385                 390                 395                 400 
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                          405                 410                 415     
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                      420                 425                 430         
          Ser Val Gln Glu Arg Gln
                  435             
          <![CDATA[<210> 333]]>
          <![CDATA[<211> 434]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 333]]>
          Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu
           1               5                  10                  15      
          Val Thr Asn Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                  275                 280                 285             
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
              290                 295                 300                 
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
          305                 310                 315                 320 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                          325                 330                 335     
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                      340                 345                 350         
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                  355                 360                 365             
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
              370                 375                 380                 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
          385                 390                 395                 400 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                          405                 410                 415     
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                      420                 425                 430         
          Arg Gln
          <![CDATA[<210> 334]]>
          <![CDATA[<211> 431]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 334]]>
          Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile
           1               5                  10                  15      
          Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser
                      20                  25                  30          
          Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser
                  35                  40                  45              
          Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu
              50                  55                  60                  
          Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr
          65                  70                  75                  80  
          Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys
                          85                  90                  95      
          Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala
                      100                 105                 110         
          Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp
                  115                 120                 125             
          Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr
          145                 150                 155                 160 
          Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr
                          165                 170                 175     
          Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp
                      180                 185                 190         
          Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys
                  195                 200                 205             
          Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser
              210                 215                 220                 
          Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly
          225                 230                 235                 240 
          Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser
                          245                 250                 255     
          Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser Ala
                      260                 265                 270         
          Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys Gly Lys His
                  275                 280                 285             
          Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val
              290                 295                 300                 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
          305                 310                 315                 320 
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                          325                 330                 335     
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                      340                 345                 350         
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                  355                 360                 365             
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
              370                 375                 380                 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
          385                 390                 395                 400 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                          405                 410                 415     
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      420                 425                 430     
          <![CDATA[<210> 335]]>
          <![CDATA[<211> 434]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 335]]>
          Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro
           1               5                  10                  15      
          Asp Thr Thr Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val
                      20                  25                  30          
          Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser
                  35                  40                  45              
          Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser
              50                  55                  60                  
          Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr
          65                  70                  75                  80  
          Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp
                          85                  90                  95      
          Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu
                      100                 105                 110         
          Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr
                  115                 120                 125             
          Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro
          145                 150                 155                 160 
          Val Leu Thr Gln Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala
                          165                 170                 175     
          Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg
                      180                 185                 190         
          Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu
                  195                 200                 205             
          Asn Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser
              210                 215                 220                 
          Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu
          225                 230                 235                 240 
          Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile
                          245                 250                 255     
          Trp His Ser Ser Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val
                      260                 265                 270         
          Leu Ser Ala Ala Ala Gly Ser Gly Gly Ser Gly Ile Ile His Val Lys
                  275                 280                 285             
          Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro
              290                 295                 300                 
          Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
          305                 310                 315                 320 
          Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser
                          325                 330                 335     
          Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly
                      340                 345                 350         
          Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala
                  355                 360                 365             
          Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
              370                 375                 380                 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
          385                 390                 395                 400 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                          405                 410                 415     
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                      420                 425                 430         
          Arg Gln
          <![CDATA[<210> 336]]>
          <![CDATA[<211> 357]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成]]>多肽
          <![CDATA[<400> 336]]>
          Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val
           1               5                  10                  15      
          Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met Thr Leu
                      20                  25                  30          
          Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln
                  35                  40                  45              
          Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His
              50                  55                  60                  
          His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly
          65                  70                  75                  80  
          Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu
                          85                  90                  95      
          Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu
                      100                 105                 110         
          Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu
                  115                 120                 125             
          Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg
              130                 135                 140                 
          Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg
          145                 150                 155                 160 
          Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu
                          165                 170                 175     
          Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala
                      180                 185                 190         
          Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His Phe Val
                  195                 200                 205             
          His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val
              210                 215                 220                 
          Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp
          225                 230                 235                 240 
          Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro
                          245                 250                 255     
          Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp
                      260                 265                 270         
          Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro
                  275                 280                 285             
          Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly
              290                 295                 300                 
          Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile
          305                 310                 315                 320 
          Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys
                          325                 330                 335     
          Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr
                      340                 345                 350         
          Leu Asp Val Leu Gly
                  355         
          <![CDATA[<210> 337]]>
          <![CDATA[<211> 199]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 337]]>
          Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Leu Cys Arg Ile Lys
           1               5                  10                  15      
          Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
                      20                  25                  30          
          Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
                  35                  40                  45              
          Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
              50                  55                  60                  
          Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
          65                  70                  75                  80  
          Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
                          85                  90                  95      
          Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
                      100                 105                 110         
          Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
                  115                 120                 125             
          His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
              130                 135                 140                 
          Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
          145                 150                 155                 160 
          Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro
                          165                 170                 175     
          Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser
                      180                 185                 190         
          Arg Leu Thr Asp Val Thr Leu
                  195                 
          <![CDATA[<210> 338]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 338]]>
          Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn
           1               5                  10                  15      
          Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg
                      20                  25                  30          
          Leu Thr Asp Val Thr Leu
                  35              
          <![CDATA[<210> 339]]>
          <![CDATA[<211> 322]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 339]]>
          Arg Asp Asn Glu Thr Ile Trp Gly Val Leu Gly His Gly Ile Thr Leu
           1               5                  10                  15      
          Asn Ile Pro Asn Phe Gln Met Thr Asp Asp Ile Asp Glu Val Arg Trp
                      20                  25                  30          
          Val Arg Arg Gly Thr Leu Val Ala Glu Phe Lys Arg Lys Lys Pro Pro
                  35                  40                  45              
          Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu Ala Asn Gly Ser Leu Lys
              50                  55                  60                  
          Ile Lys Lys Pro Met Met Arg Asn Asp Ser Gly Thr Tyr Asn Val Met
          65                  70                  75                  80  
          Val Tyr Gly Thr Asn Gly Met Thr Arg Leu Glu Lys Asp Leu Asp Val
                          85                  90                  95      
          Arg Ile Leu Glu Arg Val Ser Lys Pro Met Ile His Trp Glu Cys Pro
                      100                 105                 110         
          Asn Thr Thr Leu Thr Cys Ala Val Leu Gln Gly Thr Asp Phe Glu Leu
                  115                 120                 125             
          Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn Ser Leu Pro Gln Lys Asn
              130                 135                 140                 
          Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala Pro Phe Lys Cys Glu Ala
          145                 150                 155                 160 
          Ile Asn Pro Val Ser Lys Glu Ser Lys Met Glu Val Val Asn Cys Pro
                          165                 170                 175     
          Glu Lys Gly Leu Ser Phe Tyr Val Thr Val Gly Val Gly Ala Gly Gly
                      180                 185                 190         
          Leu Leu Leu Val Leu Leu Val Ala Leu Phe Ile Phe Cys Ile Cys Lys
                  195                 200                 205             
          Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp Glu Glu Leu Glu Ile Lys
              210                 215                 220                 
          Ala Ser Arg Thr Ser Thr Val Glu Arg Gly Pro Lys Pro His Ser Thr
          225                 230                 235                 240 
          Pro Ala Ala Ala Ala Gln Asn Ser Val Ala Leu Gln Ala Pro Pro Pro
                          245                 250                 255     
          Pro Gly His His Leu Gln Thr Pro Gly His Arg Pro Leu Pro Pro Gly
                      260                 265                 270         
          His Arg Thr Arg Glu His Gln Gln Lys Lys Arg Pro Pro Pro Ser Gly
                  275                 280                 285             
          Thr Gln Ile His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val
              290                 295                 300                 
          Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp Gly Val Ser Leu Pro Pro
          305                 310                 315                 320 
          Pro Asn
          <![CDATA[<210> 340]]>
          <![CDATA[<211> 115]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 340]]>
          Lys Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp Glu Glu Leu Glu Ile
           1               5                  10                  15      
          Lys Ala Ser Arg Thr Ser Thr Val Glu Arg Gly Pro Lys Pro His Ser
                      20                  25                  30          
          Thr Pro Ala Ala Ala Ala Gln Asn Ser Val Ala Leu Gln Ala Pro Pro
                  35                  40                  45              
          Pro Pro Gly His His Leu Gln Thr Pro Gly His Arg Pro Leu Pro Pro
              50                  55                  60                  
          Gly His Arg Thr Arg Glu His Gln Gln Lys Lys Arg Pro Pro Pro Ser
          65                  70                  75                  80  
          Gly Thr Gln Ile His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg
                          85                  90                  95      
          Val Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp Gly Val Ser Leu Pro
                      100                 105                 110         
          Pro Pro Asn
                  115 
          <![CDATA[<210> 341]]>
          <![CDATA[<211> 42]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 341]]>
          Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
           1               5                  10                  15      
          Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
                      20                  25                  30          
          Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
                  35                  40          
          <![CDATA[<210> 342]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 342]]>
          Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val
           1               5                  10                  15      
          Tyr Ile Asn Met Pro Gly Arg Gly
                      20                  
          <![CDATA[<210> 343]]>
          <![CDATA[<211> 42]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 343]]>
          Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His
           1               5                  10                  15      
          Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln
                      20                  25                  30          
          Ala Asp Ala His Ser Thr Leu Ala Lys Ile
                  35                  40          
          <![CDATA[<210> 344]]>
          <![CDATA[<211> 791]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 344]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro
                  435                 440                 445             
          Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met
              450                 455                 460                 
          Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly
          465                 470                 475                 480 
          Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys
                          485                 490                 495     
          Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly
                      500                 505                 510         
          Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu
                  515                 520                 525             
          Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala
              530                 535                 540                 
          Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr
          545                 550                 555                 560 
          Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu
                          565                 570                 575     
          Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu
                      580                 585                 590         
          Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly
                  595                 600                 605             
          Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala
              610                 615                 620                 
          Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His
          625                 630                 635                 640 
          Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly
                          645                 650                 655     
          Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser
                      660                 665                 670         
          Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp
                  675                 680                 685             
          Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp
              690                 695                 700                 
          Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys
          705                 710                 715                 720 
          Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr
                          725                 730                 735     
          Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr
                      740                 745                 750         
          Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser
                  755                 760                 765             
          Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro
              770                 775                 780                 
          Val Tyr Leu Asp Val Leu Gly
          785                 790     
          <![CDATA[<210> 345]]>
          <![CDATA[<211> 853]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 345]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Asn Lys Cys Gly Arg Arg Asn Lys Phe Gly Ile Asn Arg Pro
                  435                 440                 445             
          Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met Ser Leu His Phe Met
              450                 455                 460                 
          Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu Gly Lys Gly Ser Gly
          465                 470                 475                 480 
          Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr Phe Ser Asp Ala Cys
                          485                 490                 495     
          Val His His Ile Lys Arg Arg Asp Ile Val Leu Lys Trp Glu Leu Gly
                      500                 505                 510         
          Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys His Asn Leu Leu
                  515                 520                 525             
          Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Glu Ala
              530                 535                 540                 
          Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu Ala Glu Leu Leu Thr
          545                 550                 555                 560 
          Met Leu Gln His Gln His Ile Val Arg Phe Phe Gly Val Cys Thr Glu
                          565                 570                 575     
          Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met Arg His Gly Asp Leu
                      580                 585                 590         
          Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala Lys Leu Leu Ala Gly
                  595                 600                 605             
          Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu Gly Gln Leu Leu Ala
              610                 615                 620                 
          Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr Leu Ala Gly Leu His
          625                 630                 635                 640 
          Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Gln Gly
                          645                 650                 655     
          Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Ile Tyr Ser
                      660                 665                 670         
          Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met Leu Pro Ile Arg Trp
                  675                 680                 685             
          Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe Thr Thr Glu Ser Asp
              690                 695                 700                 
          Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys
          705                 710                 715                 720 
          Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala Ile Asp Cys Ile Thr
                          725                 730                 735     
          Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys Pro Pro Glu Val Tyr
                      740                 745                 750         
          Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg His Ser
                  755                 760                 765             
          Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu Ala Gln Ala Pro Pro
              770                 775                 780                 
          Val Tyr Leu Asp Val Leu Gly Lys Lys Val Ala Lys Lys Pro Thr Asn
          785                 790                 795                 800 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          805                 810                 815     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      820                 825                 830         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  835                 840                 845             
          Val Gln Glu Arg Gln
              850             
          <![CDATA[<210> 346]]>
          <![CDATA[<211> 832]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 346]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Asn Lys Cys Gly Arg
          465                 470                 475                 480 
          Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp
                          485                 490                 495     
          Gly Leu Ala Met Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu
                      500                 505                 510         
          Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu
                  515                 520                 525             
          Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg
              530                 535                 540                 
          Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val
          545                 550                 555                 560 
          Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu
                          565                 570                 575     
          Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp
                      580                 585                 590         
          Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile
                  595                 600                 605             
          Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val
              610                 615                 620                 
          Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His
          625                 630                 635                 640 
          Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly
                          645                 650                 655     
          Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala
                      660                 665                 670         
          Gly Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala
                  675                 680                 685             
          Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp
              690                 695                 700                 
          Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly
          705                 710                 715                 720 
          Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu
                          725                 730                 735     
          Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val
                      740                 745                 750         
          Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser
                  755                 760                 765             
          Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg
              770                 775                 780                 
          Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp
          785                 790                 795                 800 
          Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg
                          805                 810                 815     
          Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly
                      820                 825                 830         
          <![CDATA[<210> 347]]>
          <![CDATA[<211> 894]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 347]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Asn Lys Cys Gly Arg
          465                 470                 475                 480 
          Arg Asn Lys Phe Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp
                          485                 490                 495     
          Gly Leu Ala Met Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu
                      500                 505                 510         
          Ser Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu
                  515                 520                 525             
          Asn Pro Gln Tyr Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg
              530                 535                 540                 
          Asp Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val
          545                 550                 555                 560 
          Phe Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu
                          565                 570                 575     
          Val Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp
                      580                 585                 590         
          Phe Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile
                  595                 600                 605             
          Val Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val
              610                 615                 620                 
          Phe Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His
          625                 630                 635                 640 
          Gly Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly
                          645                 650                 655     
          Pro Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala
                      660                 665                 670         
          Gly Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala
                  675                 680                 685             
          Thr Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp
              690                 695                 700                 
          Phe Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly
          705                 710                 715                 720 
          Gly Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu
                          725                 730                 735     
          Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val
                      740                 745                 750         
          Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser
                  755                 760                 765             
          Asn Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg
              770                 775                 780                 
          Pro Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp
          785                 790                 795                 800 
          Gln Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg
                          805                 810                 815     
          Leu Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly
                      820                 825                 830         
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                  835                 840                 845             
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
              850                 855                 860                 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
          865                 870                 875                 880 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          885                 890                 
          <![CDATA[<210> 348]]>
          <![CDATA[<211> 517]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 348]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
                  275                 280                 285             
          Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
              290                 295                 300                 
          Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
          305                 310                 315                 320 
          Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
                          325                 330                 335     
          Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
                      340                 345                 350         
          Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
                  355                 360                 365             
          Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
              370                 375                 380                 
          His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
          385                 390                 395                 400 
          Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
                          405                 410                 415     
          Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro
                      420                 425                 430         
          Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser
                  435                 440                 445             
          Arg Leu Thr Asp Val Thr Leu Lys Lys Val Ala Lys Lys Pro Thr Asn
              450                 455                 460                 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
          465                 470                 475                 480 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                          485                 490                 495     
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                      500                 505                 510         
          Val Gln Glu Arg Gln
                  515         
          <![CDATA[<210> 349]]>
          <![CDATA[<211> 513]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 349]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu Thr Lys
          465                 470                 475                 480 
          Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe
                          485                 490                 495     
          Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr
                      500                 505                 510         
          Leu
          <![CDATA[<210> 350]]>
          <![CDATA[<211> 575]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 350]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu Thr Lys
          465                 470                 475                 480 
          Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe
                          485                 490                 495     
          Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr
                      500                 505                 510         
          Leu Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                  515                 520                 525             
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
              530                 535                 540                 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
          545                 550                 555                 560 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          565                 570                 575 
          <![CDATA[<210> 351]]>
          <![CDATA[<211> 659]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 351]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Arg Asp Asn Glu Thr Ile Trp Gly Val Leu Gly His Gly
                  275                 280                 285             
          Ile Thr Leu Asn Ile Pro Asn Phe Gln Met Thr Asp Asp Ile Asp Glu
              290                 295                 300                 
          Val Arg Trp Val Arg Arg Gly Thr Leu Val Ala Glu Phe Lys Arg Lys
          305                 310                 315                 320 
          Lys Pro Pro Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu Ala Asn Gly
                          325                 330                 335     
          Ser Leu Lys Ile Lys Lys Pro Met Met Arg Asn Asp Ser Gly Thr Tyr
                      340                 345                 350         
          Asn Val Met Val Tyr Gly Thr Asn Gly Met Thr Arg Leu Glu Lys Asp
                  355                 360                 365             
          Leu Asp Val Arg Ile Leu Glu Arg Val Ser Lys Pro Met Ile His Trp
              370                 375                 380                 
          Glu Cys Pro Asn Thr Thr Leu Thr Cys Ala Val Leu Gln Gly Thr Asp
          385                 390                 395                 400 
          Phe Glu Leu Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn Ser Leu Pro
                          405                 410                 415     
          Gln Lys Asn Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala Pro Phe Lys
                      420                 425                 430         
          Cys Glu Ala Ile Asn Pro Val Ser Lys Glu Ser Lys Met Glu Val Val
                  435                 440                 445             
          Asn Cys Pro Glu Lys Gly Leu Ser Phe Tyr Val Thr Val Gly Val Gly
              450                 455                 460                 
          Ala Gly Gly Leu Leu Leu Val Leu Leu Val Ala Leu Phe Ile Phe Cys
          465                 470                 475                 480 
          Ile Cys Lys Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp Glu Glu Leu
                          485                 490                 495     
          Glu Ile Lys Ala Ser Arg Thr Ser Thr Val Glu Arg Gly Pro Lys Pro
                      500                 505                 510         
          His Ser Thr Pro Ala Ala Ala Ala Gln Asn Ser Val Ala Leu Gln Ala
                  515                 520                 525             
          Pro Pro Pro Pro Gly His His Leu Gln Thr Pro Gly His Arg Pro Leu
              530                 535                 540                 
          Pro Pro Gly His Arg Thr Arg Glu His Gln Gln Lys Lys Arg Pro Pro
          545                 550                 555                 560 
          Pro Ser Gly Thr Gln Ile His Gln Gln Lys Gly Pro Pro Leu Pro Arg
                          565                 570                 575     
          Pro Arg Val Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp Gly Val Ser
                      580                 585                 590         
          Leu Pro Pro Pro Asn Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                  595                 600                 605             
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
              610                 615                 620                 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
          625                 630                 635                 640 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                          645                 650                 655     
          Glu Arg Gln
          <![CDATA[<210> 352]]>
          <![CDATA[<211> 590]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 352]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Arg Lys Arg
          465                 470                 475                 480 
          Asn Arg Arg Arg Lys Asp Glu Glu Leu Glu Ile Lys Ala Ser Arg Thr
                          485                 490                 495     
          Ser Thr Val Glu Arg Gly Pro Lys Pro His Ser Thr Pro Ala Ala Ala
                      500                 505                 510         
          Ala Gln Asn Ser Val Ala Leu Gln Ala Pro Pro Pro Pro Gly His His
                  515                 520                 525             
          Leu Gln Thr Pro Gly His Arg Pro Leu Pro Pro Gly His Arg Thr Arg
              530                 535                 540                 
          Glu His Gln Gln Lys Lys Arg Pro Pro Pro Ser Gly Thr Gln Ile His
          545                 550                 555                 560 
          Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro
                          565                 570                 575     
          Pro Cys Gly Ser Gly Asp Gly Val Ser Leu Pro Pro Pro Asn
                      580                 585                 590 
          <![CDATA[<210> 353]]>
          <![CDATA[<211> 652]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 353]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Arg Arg Lys Arg Asn Arg
              530                 535                 540                 
          Arg Arg Lys Asp Glu Glu Leu Glu Ile Lys Ala Ser Arg Thr Ser Thr
          545                 550                 555                 560 
          Val Glu Arg Gly Pro Lys Pro His Ser Thr Pro Ala Ala Ala Ala Gln
                          565                 570                 575     
          Asn Ser Val Ala Leu Gln Ala Pro Pro Pro Pro Gly His His Leu Gln
                      580                 585                 590         
          Thr Pro Gly His Arg Pro Leu Pro Pro Gly His Arg Thr Arg Glu His
                  595                 600                 605             
          Gln Gln Lys Lys Arg Pro Pro Pro Ser Gly Thr Gln Ile His Gln Gln
              610                 615                 620                 
          Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro Cys
          625                 630                 635                 640 
          Gly Ser Gly Asp Gly Val Ser Leu Pro Pro Pro Asn
                          645                 650         
          <![CDATA[<210> 354]]>
          <![CDATA[<211> 517]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 354]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys
          465                 470                 475                 480 
          Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
                          485                 490                 495     
          Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
                      500                 505                 510         
          Gly Gly Cys Glu Leu
                  515         
          <![CDATA[<210> 355]]>
          <![CDATA[<211> 579]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 355]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Arg Gly Arg Lys Lys Leu
              530                 535                 540                 
          Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln
          545                 550                 555                 560 
          Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly
                          565                 570                 575     
          Cys Glu Leu
          <![CDATA[<210> 356]]>
          <![CDATA[<211> 499]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 356]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Cys Ala Arg Pro
          465                 470                 475                 480 
          Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro
                          485                 490                 495     
          Gly Arg Gly
          <![CDATA[<210> 357]]>
          <![CDATA[<211> 561]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 357]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln Leu Cys Ala Arg Pro Arg Arg
              530                 535                 540                 
          Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg
          545                 550                 555                 560 
          Gly
          <![CDATA[<210> 358]]>
          <![CDATA[<211> 517]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 358]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Ala Leu Tyr Leu Leu
          465                 470                 475                 480 
          Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly
                          485                 490                 495     
          Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser
                      500                 505                 510         
          Thr Leu Ala Lys Ile
                  515         
          <![CDATA[<210> 359]]>
          <![CDATA[<211> 579]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 359]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Lys Leu Glu Gln Ser
                      20                  25                  30          
          Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Gly Gln Arg Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ala Asn Thr Ala Tyr Leu Gly Leu Ser Ser Leu Arg
                      100                 105                 110         
          Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly
                          165                 170                 175     
          Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Gln Pro Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Gly Ser Gly
                      260                 265                 270         
          Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp
                  275                 280                 285             
          Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg
              290                 295                 300                 
          Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val
          305                 310                 315                 320 
          Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys
                          325                 330                 335     
          Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe
                      340                 345                 350         
          Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys
                  355                 360                 365             
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
              370                 375                 380                 
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
          385                 390                 395                 400 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          405                 410                 415     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      420                 425                 430         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  435                 440                 445             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              450                 455                 460                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln Ala Leu Tyr Leu Leu Arg Arg
              530                 535                 540                 
          Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser
          545                 550                 555                 560 
          Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu
                          565                 570                 575     
          Ala Lys Ile
          <![CDATA[<210> 360]]>
          <![CDATA[<211> 295]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 360]]>
          Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
           1               5                  10                  15      
          Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
                      20                  25                  30          
          Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
                  35                  40                  45              
          Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
              50                  55                  60                  
          Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
          65                  70                  75                  80  
          Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                          85                  90                  95      
          Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
                      100                 105                 110         
          Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
                  115                 120                 125             
          Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
              130                 135                 140                 
          Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
          145                 150                 155                 160 
          Arg Pro Ala Gly Gln Phe Trp Val Leu Val Val Val Gly Gly Val Leu
                          165                 170                 175     
          Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
                      180                 185                 190         
          Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
                  195                 200                 205             
          Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
              210                 215                 220                 
          Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys Pro
          225                 230                 235                 240 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          245                 250                 255     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      260                 265                 270         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  275                 280                 285             
          Ile Ser Val Gln Glu Arg Gln
              290                 295 
          <![CDATA[<210> 361]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 361]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ala Val Gln Ala Arg Gln
              530                 535             
          <![CDATA[<210> 362]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成]]>多肽
          <![CDATA[<400> 362]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Ala Val
                      500                 505                 510         
          Ala Glu Ala Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 363]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 363]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Ala Gln Ala
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 364]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 364]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Ala His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 365]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 365]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Ala Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 366]]>
          <![CDATA[<211> 600]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 366]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Ala Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Lys Val Ala Lys Lys
              530                 535                 540                 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
          545                 550                 555                 560 
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                          565                 570                 575     
          Thr Leu His Gly Cys Gln Pro Val Thr Ala Glu Asp Gly Lys Glu Ser
                      580                 585                 590         
          Arg Ile Ser Val Gln Glu Arg Gln
                  595                 600 
          <![CDATA[<210> 367]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 367]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala
              450                 455                 460                 
          Tyr Ala Ala Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 368]]>
          <![CDATA[<211> 538]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 368]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Phe Met
                  435                 440                 445             
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
              450                 455                 460                 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
          465                 470                 475                 480 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          485                 490                 495     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      500                 505                 510         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  515                 520                 525             
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535             
          <![CDATA[<210> 369]]>
          <![CDATA[<211> 497]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 369]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                  435                 440                 445             
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
              450                 455                 460                 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
          465                 470                 475                 480 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                          485                 490                 495     
          Gln
          <![CDATA[<210> 370]]>
          <![CDATA[<211> 543]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 370]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu
                  435                 440                 445             
          Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
              450                 455                 460                 
          Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
          465                 470                 475                 480 
          Glu Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                          485                 490                 495     
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                      500                 505                 510         
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                  515                 520                 525             
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540             
          <![CDATA[<210> 371]]>
          <![CDATA[<211> 534]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 371]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro
                  435                 440                 445             
          Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp
              450                 455                 460                 
          Ala His Ser Thr Leu Ala Lys Ile Lys Lys Val Ala Lys Lys Pro Thr
          465                 470                 475                 480 
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                          485                 490                 495     
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                      500                 505                 510         
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
                  515                 520                 525             
          Ser Val Gln Glu Arg Gln
              530                 
          <![CDATA[<210> 372]]>
          <![CDATA[<211> 613]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 372]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu
                  435                 440                 445             
          Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys
              450                 455                 460                 
          Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln
          465                 470                 475                 480 
          His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg
                          485                 490                 495     
          Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro
                      500                 505                 510         
          Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu
                  515                 520                 525             
          Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn
              530                 535                 540                 
          Ser Leu Ser Pro Ser Ser Asn Lys Lys Val Ala Lys Lys Pro Thr Asn
          545                 550                 555                 560 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                          565                 570                 575     
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                      580                 585                 590         
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                  595                 600                 605             
          Val Gln Glu Arg Gln
              610             
          <![CDATA[<210> 373]]>
          <![CDATA[<211> 555]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 373]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys
                  435                 440                 445             
          Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr
              450                 455                 460                 
          Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg
          465                 470                 475                 480 
          Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp Val Lys Lys Val
                          485                 490                 495     
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                      500                 505                 510         
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                  515                 520                 525             
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
              530                 535                 540                 
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          545                 550                 555 
          <![CDATA[<210> 374]]>
          <![CDATA[<211> 544]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 374]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala
                  435                 440                 445             
          Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn
              450                 455                 460                 
          Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu
          465                 470                 475                 480 
          Gly Lys Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                          485                 490                 495     
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                      500                 505                 510         
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                  515                 520                 525             
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540                 
          <![CDATA[<210> 375]]>
          <![CDATA[<211> 572]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 375]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
                  275                 280                 285             
          Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
              290                 295                 300                 
          Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
          305                 310                 315                 320 
          Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
                          325                 330                 335     
          Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
                      340                 345                 350         
          Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
                  355                 360                 365             
          Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
              370                 375                 380                 
          Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
          385                 390                 395                 400 
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                          405                 410                 415     
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                      420                 425                 430         
          Phe Trp Val Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr Val
                  435                 440                 445             
          Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly Pro
              450                 455                 460                 
          Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr Thr
          465                 470                 475                 480 
          Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu Thr
                          485                 490                 495     
          Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser Lys Lys
                      500                 505                 510         
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                  515                 520                 525             
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
              530                 535                 540                 
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
          545                 550                 555                 560 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          565                 570         
          <![CDATA[<210> 376]]>
          <![CDATA[<211> 421]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 376]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Lys Lys Val Ala Lys Lys Pro Thr Asn
                  355                 360                 365             
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
              370                 375                 380                 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
          385                 390                 395                 400 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                          405                 410                 415     
          Val Gln Glu Arg Gln
                      420     
          <![CDATA[<210> 377]]>
          <![CDATA[<211> 467]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 377]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val Lys Arg Gly Arg
                  355                 360                 365             
          Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
              370                 375                 380                 
          Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
          385                 390                 395                 400 
          Glu Gly Gly Cys Glu Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                          405                 410                 415     
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
                      420                 425                 430         
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                  435                 440                 445             
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
              450                 455                 460                 
          Glu Arg Gln
          465         
          <![CDATA[<210> 378]]>
          <![CDATA[<211> 457]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 378]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Arg Asp Gln Arg Leu Pro Pro Asp
                  355                 360                 365             
          Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu
              370                 375                 380                 
          Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Lys Lys Val Ala
          385                 390                 395                 400 
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                          405                 410                 415     
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                      420                 425                 430         
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
                  435                 440                 445             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455         
          <![CDATA[<210> 379]]>
          <![CDATA[<211> 537]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 379]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Lys Arg Lys Lys Gln Arg Ser Arg Arg
                  355                 360                 365             
          Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu
              370                 375                 380                 
          Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro
          385                 390                 395                 400 
          Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala
                          405                 410                 415     
          Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro
                      420                 425                 430         
          Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys
                  435                 440                 445             
          Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly
              450                 455                 460                 
          Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys Val Ala Lys
          465                 470                 475                 480 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          485                 490                 495     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      500                 505                 510         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  515                 520                 525             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535         
          <![CDATA[<210> 380]]>
          <![CDATA[<211> 479]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 380]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Gln Leu Gly Leu His Ile Trp Gln Leu
                  355                 360                 365             
          Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val
              370                 375                 380                 
          Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu
          385                 390                 395                 400 
          Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp
                          405                 410                 415     
          Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                      420                 425                 430         
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
                  435                 440                 445             
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
              450                 455                 460                 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          465                 470                 475                 
          <![CDATA[<210> 381]]>
          <![CDATA[<211> 468]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 381]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Lys Leu Leu Met Ile Ile His Asp Arg
                  355                 360                 365             
          Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp
              370                 375                 380                 
          Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn
          385                 390                 395                 400 
          Pro Lys Tyr Glu Gly Lys Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                          405                 410                 415     
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                      420                 425                 430         
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
                  435                 440                 445             
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
              450                 455                 460                 
          Gln Glu Arg Gln
          465             
          <![CDATA[<210> 382]]>
          <![CDATA[<211> 496]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 382]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Gly Lys Thr Asn His Tyr
                  355                 360                 365             
          Gln Thr Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln
              370                 375                 380                 
          Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp
          385                 390                 395                 400 
          Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser
                          405                 410                 415     
          Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro
                      420                 425                 430         
          Glu Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                  435                 440                 445             
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
              450                 455                 460                 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
          465                 470                 475                 480 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          485                 490                 495     
          <![CDATA[<210> 383]]>
          <![CDATA[<211> 636]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 383]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
              530                 535                 540                 
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
          545                 550                 555                 560 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                          565                 570                 575     
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                      580                 585                 590         
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                  595                 600                 605             
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
              610                 615                 620                 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          625                 630                 635     
          <![CDATA[<210> 384]]>
          <![CDATA[<211> 595]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 384]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
              530                 535                 540                 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
          545                 550                 555                 560 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                          565                 570                 575     
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                      580                 585                 590         
          Glu Arg Gln
                  595 
          <![CDATA[<210> 385]]>
          <![CDATA[<211> 595]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 385]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
              530                 535                 540                 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
          545                 550                 555                 560 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                          565                 570                 575     
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                      580                 585                 590         
          Glu Arg Gln
                  595 
          <![CDATA[<210> 386]]>
          <![CDATA[<211> 632]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 386]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His
              530                 535                 540                 
          Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln
          545                 550                 555                 560 
          Ala Asp Ala His Ser Thr Leu Ala Lys Ile Lys Lys Val Ala Lys Lys
                          565                 570                 575     
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                      580                 585                 590         
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                  595                 600                 605             
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
              610                 615                 620                 
          Arg Ile Ser Val Gln Glu Arg Gln
          625                 630         
          <![CDATA[<210> 387]]>
          <![CDATA[<211> 711]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 387]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp
              530                 535                 540                 
          Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly
          545                 550                 555                 560 
          Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr
                          565                 570                 575     
          Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser
                      580                 585                 590         
          His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys
                  595                 600                 605             
          Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro
              610                 615                 620                 
          Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala
          625                 630                 635                 640 
          Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys Val Ala Lys Lys Pro
                          645                 650                 655     
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                      660                 665                 670         
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                  675                 680                 685             
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
              690                 695                 700                 
          Ile Ser Val Gln Glu Arg Gln
          705                 710     
          <![CDATA[<210> 388]]>
          <![CDATA[<211> 653]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 388]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser
              530                 535                 540                 
          Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro
          545                 550                 555                 560 
          Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly
                          565                 570                 575     
          Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp Val Lys
                      580                 585                 590         
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                  595                 600                 605             
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
              610                 615                 620                 
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
          625                 630                 635                 640 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          645                 650             
          <![CDATA[<210> 389]]>
          <![CDATA[<211> 642]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 389]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu
              530                 535                 540                 
          Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gly
          545                 550                 555                 560 
          Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn Pro Lys
                          565                 570                 575     
          Tyr Glu Gly Lys Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                      580                 585                 590         
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                  595                 600                 605             
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
              610                 615                 620                 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
          625                 630                 635                 640 
          Arg Gln
          <![CDATA[<210> 390]]>
          <![CDATA[<211> 670]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 3]]>90
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr
              530                 535                 540                 
          Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro
          545                 550                 555                 560 
          Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys
                          565                 570                 575     
          Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln
                      580                 585                 590         
          Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser
                  595                 600                 605             
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
              610                 615                 620                 
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
          625                 630                 635                 640 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                          645                 650                 655     
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      660                 665                 670 
          <![CDATA[<210> 391]]>
          <![CDATA[<211> 658]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 391]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
              530                 535                 540                 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
          545                 550                 555                 560 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                          565                 570                 575     
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      580                 585                 590         
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                  595                 600                 605             
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
              610                 615                 620                 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
          625                 630                 635                 640 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Lys Lys
                          645                 650                 655     
          Val Ala
          <![CDATA[<210> 392]]>
          <![CDATA[<211> 595]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 392]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro
                  275                 280                 285             
          Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
              290                 295                 300                 
          Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
          305                 310                 315                 320 
          Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
                          325                 330                 335     
          Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
                      340                 345                 350         
          Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
                  355                 360                 365             
          Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
              370                 375                 380                 
          Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
          385                 390                 395                 400 
          Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met
                          405                 410                 415     
          Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
                      420                 425                 430         
          Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                  435                 440                 445             
          Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
              450                 455                 460                 
          Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val
          465                 470                 475                 480 
          Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
                          485                 490                 495     
          Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val
                      500                 505                 510         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  515                 520                 525             
          Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
              530                 535                 540                 
          Ala His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
          545                 550                 555                 560 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                          565                 570                 575     
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                      580                 585                 590         
          Glu Arg Gln
                  595 
          <![CDATA[<210> 393]]>
          <![CDATA[<211> 554]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 393]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro
                  275                 280                 285             
          Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly
              290                 295                 300                 
          Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe
          305                 310                 315                 320 
          Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu
                          325                 330                 335     
          Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe
                      340                 345                 350         
          Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val
                  355                 360                 365             
          Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser
              370                 375                 380                 
          Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg
          385                 390                 395                 400 
          Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro
                          405                 410                 415     
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                      420                 425                 430         
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                  435                 440                 445             
          Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
              450                 455                 460                 
          Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
          465                 470                 475                 480 
          Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala
                          485                 490                 495     
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                      500                 505                 510         
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                  515                 520                 525             
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
              530                 535                 540                 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          545                 550                 
          <![CDATA[<210> 394]]>
          <![CDATA[<211> 513]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 394]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro
                  275                 280                 285             
          Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly
              290                 295                 300                 
          Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe
          305                 310                 315                 320 
          Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu
                          325                 330                 335     
          Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe
                      340                 345                 350         
          Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val
                  355                 360                 365             
          Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser
              370                 375                 380                 
          Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg
          385                 390                 395                 400 
          Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro
                          405                 410                 415     
          Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
                      420                 425                 430         
          Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
                  435                 440                 445             
          Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
              450                 455                 460                 
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
          465                 470                 475                 480 
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                          485                 490                 495     
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
                      500                 505                 510         
          Gln
          <![CDATA[<210> 395]]>
          <![CDATA[<211> 526]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 395]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile
                  275                 280                 285             
          Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser
              290                 295                 300                 
          Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu
          305                 310                 315                 320 
          Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe
                          325                 330                 335     
          Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser
                      340                 345                 350         
          Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr
                  355                 360                 365             
          Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser
              370                 375                 380                 
          Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val Leu
          385                 390                 395                 400 
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                          405                 410                 415     
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
                      420                 425                 430         
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
                  435                 440                 445             
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
              450                 455                 460                 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
          465                 470                 475                 480 
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                          485                 490                 495     
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                      500                 505                 510         
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525     
          <![CDATA[<210> 396]]>
          <![CDATA[<211> 485]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 396]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile
                  275                 280                 285             
          Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser
              290                 295                 300                 
          Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu
          305                 310                 315                 320 
          Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe
                          325                 330                 335     
          Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser
                      340                 345                 350         
          Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr
                  355                 360                 365             
          Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser
              370                 375                 380                 
          Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val Leu
          385                 390                 395                 400 
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                          405                 410                 415     
          Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn
                      420                 425                 430         
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                  435                 440                 445             
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
              450                 455                 460                 
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
          465                 470                 475                 480 
          Val Gln Glu Arg Gln
                          485 
          <![CDATA[<210> 397]]>
          <![CDATA[<211> 540]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 397]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
                  435                 440                 445             
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
              450                 455                 460                 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
          465                 470                 475                 480 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          485                 490                 495     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      500                 505                 510         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  515                 520                 525             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 540 
          <![CDATA[<210> 398]]>
          <![CDATA[<211> 499]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 398]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
                  435                 440                 445             
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
              450                 455                 460                 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
          465                 470                 475                 480 
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                          485                 490                 495     
          Glu Arg Gln
          <![CDATA[<210> 399]]>
          <![CDATA[<211> 545]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 399]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys
                  435                 440                 445             
          Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr
              450                 455                 460                 
          Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly
          465                 470                 475                 480 
          Gly Cys Glu Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                          485                 490                 495     
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                      500                 505                 510         
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
                  515                 520                 525             
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
              530                 535                 540                 
          Gln
          545 
          <![CDATA[<210> 400]]>
          <![CDATA[<211> 536]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220]]>> ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 400]]&gt;
          <br/><![CDATA[Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His
                  435                 440                 445             
          Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln
              450                 455                 460                 
          Ala Asp Ala His Ser Thr Leu Ala Lys Ile Lys Lys Val Ala Lys Lys
          465                 470                 475                 480 
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
                          485                 490                 495     
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
                      500                 505                 510         
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                  515                 520                 525             
          Arg Ile Ser Val Gln Glu Arg Gln
              530                 535     
          <![CDATA[<210> 401]]>
          <![CDATA[<211> 615]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 401]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp
                  435                 440                 445             
          Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly
              450                 455                 460                 
          Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr
          465                 470                 475                 480 
          Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser
                          485                 490                 495     
          His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys
                      500                 505                 510         
          Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro
                  515                 520                 525             
          Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala
              530                 535                 540                 
          Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys Val Ala Lys Lys Pro
          545                 550                 555                 560 
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                          565                 570                 575     
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
                      580                 585                 590         
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                  595                 600                 605             
          Ile Ser Val Gln Glu Arg Gln
              610                 615 
          <![CDATA[<210> 402]]>
          <![CDATA[<211> 557]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 402]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser
                  435                 440                 445             
          Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro
              450                 455                 460                 
          Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly
          465                 470                 475                 480 
          Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp Val Lys
                          485                 490                 495     
          Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu
                      500                 505                 510         
          Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala
                  515                 520                 525             
          Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu
              530                 535                 540                 
          Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          545                 550                 555         
          <![CDATA[<210> 403]]>
          <![CDATA[<211> 546]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 403]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu
                  435                 440                 445             
          Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gly
              450                 455                 460                 
          Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn Pro Lys
          465                 470                 475                 480 
          Tyr Glu Gly Lys Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                          485                 490                 495     
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
                      500                 505                 510         
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                  515                 520                 525             
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
              530                 535                 540                 
          Arg Gln
          545     
          <![CDATA[<210> 404]]>
          <![CDATA[<211> 574]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 404]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Ile Leu Val Lys Gln Ser Pro Met Leu Val
                  275                 280                 285             
          Ala Tyr Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu
              290                 295                 300                 
          Phe Ser Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala
          305                 310                 315                 320 
          Val Glu Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val
                          325                 330                 335     
          Tyr Ser Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser
                      340                 345                 350         
          Val Thr Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr
                  355                 360                 365             
          Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
              370                 375                 380                 
          Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
          385                 390                 395                 400 
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                          405                 410                 415     
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                      420                 425                 430         
          Ile Ile Phe Trp Val Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr
                  435                 440                 445             
          Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro
              450                 455                 460                 
          Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys
          465                 470                 475                 480 
          Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln
                          485                 490                 495     
          Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser
                      500                 505                 510         
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                  515                 520                 525             
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
              530                 535                 540                 
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
          545                 550                 555                 560 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          565                 570                 
          <![CDATA[<210]]>> 405]]&gt;
          <br/>&lt;![CDATA[&lt;211&gt; 464]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt; PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt; 人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt; ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 405]]&gt;
          <br/><![CDATA[Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu
                  355                 360                 365             
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
              370                 375                 380                 
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
          385                 390                 395                 400 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                          405                 410                 415     
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                      420                 425                 430         
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                  435                 440                 445             
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460                 
          <![CDATA[<210> 406]]>
          <![CDATA[<211> 423]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 406]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Lys Val Ala Lys Lys Pro
                  355                 360                 365             
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
              370                 375                 380                 
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
          385                 390                 395                 400 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
                          405                 410                 415     
          Ile Ser Val Gln Glu Arg Gln
                      420             
          <![CDATA[<210> 407]]>
          <![CDATA[<211> 469]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 407]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Phe Ser Val Val Lys Arg
                  355                 360                 365             
          Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
              370                 375                 380                 
          Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
          385                 390                 395                 400 
          Glu Glu Glu Gly Gly Cys Glu Lys Lys Val Ala Lys Lys Pro Thr Asn
                          405                 410                 415     
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
                      420                 425                 430         
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                  435                 440                 445             
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
              450                 455                 460                 
          Val Gln Glu Arg Gln
          465                 
          <![CDATA[<210> 408]]>
          <![CDATA[<211> 459]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 408]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Asp Gln Arg Leu Pro
                  355                 360                 365             
          Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile
              370                 375                 380                 
          Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Lys Lys
          385                 390                 395                 400 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          405                 410                 415     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      420                 425                 430         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  435                 440                 445             
          Gly Lys Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 
          <![CDATA[<210> 409]]>
          <![CDATA[<211> 539]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 409]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Lys Lys Gln Arg Ser
                  355                 360                 365             
          Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr
              370                 375                 380                 
          Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln
          385                 390                 395                 400 
          Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser
                          405                 410                 415     
          Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln His
                      420                 425                 430         
          Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln
                  435                 440                 445             
          Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro
              450                 455                 460                 
          His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys Val
          465                 470                 475                 480 
          Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln
                          485                 490                 495     
          Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro
                      500                 505                 510         
          Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly
                  515                 520                 525             
          Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              530                 535                 
          <![CDATA[<210> 410]]>
          <![CDATA[<211> 481]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 410]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Gln Leu Gly Leu His Ile Trp
                  355                 360                 365             
          Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu
              370                 375                 380                 
          Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu
          385                 390                 395                 400 
          Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp
                          405                 410                 415     
          Leu Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His
                      420                 425                 430         
          Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly
                  435                 440                 445             
          Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro
              450                 455                 460                 
          Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg
          465                 470                 475                 480 
          Gln
          <![CDATA[<210> 411]]>
          <![CDATA[<211> 470]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 411]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Leu Leu Met Ile Ile His
                  355                 360                 365             
          Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys
              370                 375                 380                 
          Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val
          385                 390                 395                 400 
          Val Asn Pro Lys Tyr Glu Gly Lys Lys Lys Val Ala Lys Lys Pro Thr
                          405                 410                 415     
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                      420                 425                 430         
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                  435                 440                 445             
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
              450                 455                 460                 
          Ser Val Gln Glu Arg Gln
          465                 470 
          <![CDATA[<210> 412]]>
          <![CDATA[<211> 498]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 412]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro
                  275                 280                 285             
          Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
              290                 295                 300                 
          Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          305                 310                 315                 320 
          Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
                          325                 330                 335     
          Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
                      340                 345                 350         
          Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Gly Lys Thr Asn
                  355                 360                 365             
          His Tyr Gln Thr Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln
              370                 375                 380                 
          Val Gln Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala
          385                 390                 395                 400 
          Gln Asp Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro
                          405                 410                 415     
          Glu Ser Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr
                      420                 425                 430         
          Leu Pro Glu Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
                  435                 440                 445             
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
              450                 455                 460                 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
          465                 470                 475                 480 
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                          485                 490                 495     
          Arg Gln
          <![CDATA[<210> 413]]>
          <![CDATA[<211> 638]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 413]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His
              530                 535                 540                 
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
          545                 550                 555                 560 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                          565                 570                 575     
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                      580                 585                 590         
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                  595                 600                 605             
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
              610                 615                 620                 
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          625                 630                 635             
          <![CDATA[<210> 414]]>
          <![CDATA[<211> 597]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 414]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn
              530                 535                 540                 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
          545                 550                 555                 560 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                          565                 570                 575     
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                      580                 585                 590         
          Val Gln Glu Arg Gln
                  595         
          <![CDATA[<210> 415]]>
          <![CDATA[<211> 597]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 415]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn
              530                 535                 540                 
          Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
          545                 550                 555                 560 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                          565                 570                 575     
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                      580                 585                 590         
          Val Gln Glu Arg Gln
                  595         
          <![CDATA[<210> 416]]>
          <![CDATA[<211> 634]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 416]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Arg Arg Asp Gln Arg Leu Pro Pro Asp
              530                 535                 540                 
          Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu
          545                 550                 555                 560 
          Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Lys Lys Val Ala
                          565                 570                 575     
          Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu
                      580                 585                 590         
          Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val
                  595                 600                 605             
          Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys
              610                 615                 620                 
          Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          625                 630                 
          <![CDATA[<210> 417]]>
          <![CDATA[<211> 713]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 417]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Lys Arg Lys Lys Gln Arg Ser Arg Arg
              530                 535                 540                 
          Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu
          545                 550                 555                 560 
          Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro
                          565                 570                 575     
          Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala
                      580                 585                 590         
          Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro
                  595                 600                 605             
          Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys
              610                 615                 620                 
          Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly
          625                 630                 635                 640 
          Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys Val Ala Lys
                          645                 650                 655     
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                      660                 665                 670         
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                  675                 680                 685             
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
              690                 695                 700                 
          Ser Arg Ile Ser Val Gln Glu Arg Gln
          705                 710             
          <![CDATA[<210> 418]]>
          <![CDATA[<211> 655]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 418]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Gln Leu Gly Leu His Ile Trp Gln Leu
              530                 535                 540                 
          Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val
          545                 550                 555                 560 
          Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu
                          565                 570                 575     
          Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp
                      580                 585                 590         
          Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
                  595                 600                 605             
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
              610                 615                 620                 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
          625                 630                 635                 640 
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          645                 650                 655 
          <![CDATA[<210> 419]]>
          <![CDATA[<211> 644]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 419]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Lys Leu Leu Met Ile Ile His Asp Arg
              530                 535                 540                 
          Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp
          545                 550                 555                 560 
          Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn
                          565                 570                 575     
          Pro Lys Tyr Glu Gly Lys Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                      580                 585                 590         
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
                  595                 600                 605             
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
              610                 615                 620                 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
          625                 630                 635                 640 
          Gln Glu Arg Gln
          <![CDATA[<210> 420]]>
          <![CDATA[<211> 672]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 420]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Arg Arg Arg Gly Lys Thr Asn His Tyr
              530                 535                 540                 
          Gln Thr Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln
          545                 550                 555                 560 
          Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp
                          565                 570                 575     
          Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser
                      580                 585                 590         
          Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro
                  595                 600                 605             
          Glu Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
              610                 615                 620                 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
          625                 630                 635                 640 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                          645                 650                 655     
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      660                 665                 670         
          <![CDATA[<210> 421]]>
          <![CDATA[<211> 660]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 421]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Ala Lys Lys Pro Thr Asn Lys Ala Pro
              530                 535                 540                 
          His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro
          545                 550                 555                 560 
          Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln
                          565                 570                 575     
          Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu
                      580                 585                 590         
          Arg Gln Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
                  595                 600                 605             
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
              610                 615                 620                 
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
          625                 630                 635                 640 
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                          645                 650                 655     
          Lys Lys Val Ala
                      660 
          <![CDATA[<210> 422]]>
          <![CDATA[<211> 597]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 422]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser
                  275                 280                 285             
          Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
              290                 295                 300                 
          Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
          305                 310                 315                 320 
          Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn
                          325                 330                 335     
          Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
                      340                 345                 350         
          Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                  355                 360                 365             
          Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
              370                 375                 380                 
          Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
          385                 390                 395                 400 
          Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
                          405                 410                 415     
          Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
                      420                 425                 430         
          Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                  435                 440                 445             
          Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
              450                 455                 460                 
          Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
          465                 470                 475                 480 
          Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                          485                 490                 495     
          Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu
                      500                 505                 510         
          Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val
                  515                 520                 525             
          Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn
              530                 535                 540                 
          Lys Ala Ala His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp
          545                 550                 555                 560 
          Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His
                          565                 570                 575     
          Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser
                      580                 585                 590         
          Val Gln Glu Arg Gln
                  595         
          <![CDATA[<210> 423]]>
          <![CDATA[<211> 297]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 423]]>
          Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
           1               5                  10                  15      
          Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
                      20                  25                  30          
          Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
                  35                  40                  45              
          Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
              50                  55                  60                  
          Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
          65                  70                  75                  80  
          Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                          85                  90                  95      
          Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
                      100                 105                 110         
          Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
                  115                 120                 125             
          Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
              130                 135                 140                 
          Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro Ser Pro Leu
          145                 150                 155                 160 
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                          165                 170                 175     
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
                      180                 185                 190         
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
                  195                 200                 205             
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
              210                 215                 220                 
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys
          225                 230                 235                 240 
          Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile
                          245                 250                 255     
          Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln
                      260                 265                 270         
          Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu
                  275                 280                 285             
          Ser Arg Ile Ser Val Gln Glu Arg Gln
              290                 295         
          <![CDATA[<210> 424]]>
          <![CDATA[<211> 260]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<22]]>3> 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 424]]&gt;
          <br/><![CDATA[Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
           1               5                  10                  15      
          Leu Gly Trp Arg Pro Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro
                      20                  25                  30          
          Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val
                  35                  40                  45              
          Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser
              50                  55                  60                  
          Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr
          65                  70                  75                  80  
          Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp
                          85                  90                  95      
          Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met
                      100                 105                 110         
          Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly
                  115                 120                 125             
          Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala
              130                 135                 140                 
          Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys
          145                 150                 155                 160 
          Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val
                          165                 170                 175     
          Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala
                      180                 185                 190         
          Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys
                  195                 200                 205             
          Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp
              210                 215                 220                 
          Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly
          225                 230                 235                 240 
          Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val
                          245                 250                 255     
          Gln Glu Arg Gln
                      260 
          <![CDATA[<210> 425]]>
          <![CDATA[<211> 271]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 425]]>
          Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
           1               5                  10                  15      
          Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn
                      20                  25                  30          
          Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser
                  35                  40                  45              
          Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln
              50                  55                  60                  
          Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser
          65                  70                  75                  80  
          Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln
                          85                  90                  95      
          Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr
                      100                 105                 110         
          Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu
                  115                 120                 125             
          Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val
              130                 135                 140                 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
          145                 150                 155                 160 
          Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu
                          165                 170                 175     
          His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg
                      180                 185                 190         
          Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg
                  195                 200                 205             
          Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys
              210                 215                 220                 
          Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn
          225                 230                 235                 240 
          Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr
                          245                 250                 255     
          Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                      260                 265                 270     
          <![CDATA[<210> 426]]>
          <![CDATA[<211> 230]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 426]]>
          Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
           1               5                  10                  15      
          Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn
                      20                  25                  30          
          Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser
                  35                  40                  45              
          Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln
              50                  55                  60                  
          Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser
          65                  70                  75                  80  
          Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln
                          85                  90                  95      
          Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr
                      100                 105                 110         
          Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu
                  115                 120                 125             
          Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp Val
              130                 135                 140                 
          Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr
          145                 150                 155                 160 
          Val Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr
                          165                 170                 175     
          Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro
                      180                 185                 190         
          Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu
                  195                 200                 205             
          His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile
              210                 215                 220                 
          Ser Val Gln Glu Arg Gln
          225                 230 
          <![CDATA[<210> 427]]>
          <![CDATA[<211> 556]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<40]]>0> 427]]&gt;
          <br/><![CDATA[Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp
                  275                 280                 285             
          Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr
              290                 295                 300                 
          Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu
          305                 310                 315                 320 
          Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp
                          325                 330                 335     
          Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys
                      340                 345                 350         
          Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser
                  355                 360                 365             
          Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala
              370                 375                 380                 
          Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu
          385                 390                 395                 400 
          Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro
                          405                 410                 415     
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                      420                 425                 430         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  435                 440                 445             
          Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
              450                 455                 460                 
          Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
          465                 470                 475                 480 
          Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys
                          485                 490                 495     
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                      500                 505                 510         
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                  515                 520                 525             
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
              530                 535                 540                 
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
          545                 550                 555     
          <![CDATA[<210> 428]]>
          <![CDATA[<211> 515]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 428]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp
                  275                 280                 285             
          Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr
              290                 295                 300                 
          Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu
          305                 310                 315                 320 
          Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp
                          325                 330                 335     
          Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys
                      340                 345                 350         
          Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser
                  355                 360                 365             
          Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala
              370                 375                 380                 
          Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu
          385                 390                 395                 400 
          Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Cys Pro
                          405                 410                 415     
          Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
                      420                 425                 430         
          Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
                  435                 440                 445             
          Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala
              450                 455                 460                 
          Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu
          465                 470                 475                 480 
          Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
                          485                 490                 495     
          Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln
                      500                 505                 510         
          Glu Arg Gln
                  515 
          <![CDATA[<210> 429]]>
          <![CDATA[<211> 528]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 429]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly
                  275                 280                 285             
          Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu
              290                 295                 300                 
          Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp
          305                 310                 315                 320 
          Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro
                          325                 330                 335     
          Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu
                      340                 345                 350         
          Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His
                  355                 360                 365             
          Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu
              370                 375                 380                 
          Glu Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp
          385                 390                 395                 400 
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                          405                 410                 415     
          Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu
                      420                 425                 430         
          Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr
                  435                 440                 445             
          Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr
              450                 455                 460                 
          Arg Ser Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro
          465                 470                 475                 480 
          Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser
                          485                 490                 495     
          Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val
                      500                 505                 510         
          Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
                  515                 520                 525             
          <![CDATA[<210> 430]]>
          <![CDATA[<211> 487]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 430]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
                  35                  40                  45              
          Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
              50                  55                  60                  
          Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile His Pro Tyr Asp
          65                  70                  75                  80  
          Gly Asp Thr Phe Tyr Asn Gln Asn Phe Lys Asp Lys Ala Thr Leu Thr
                          85                  90                  95      
          Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Leu Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Phe Ala Val Tyr Tyr Cys Thr Arg Tyr Asp Gly Ser Arg
                  115                 120                 125             
          Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly
              130                 135                 140                 
          Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile
          145                 150                 155                 160 
          Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg
                          165                 170                 175     
          Ala Ile Ile Ser Cys Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr
                      180                 185                 190         
          Ser Leu Met His Trp Tyr His Gln Lys Pro Gly Gln Gln Pro Lys Leu
                  195                 200                 205             
          Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ala Gly Val Pro Thr Arg Phe
              210                 215                 220                 
          Ser Gly Ser Gly Ser Lys Thr Asp Phe Thr Leu Asn Ile His Pro Val
          225                 230                 235                 240 
          Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu Tyr
                          245                 250                 255     
          Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala
                      260                 265                 270         
          Gly Ser Gly Gly Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly
                  275                 280                 285             
          Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu
              290                 295                 300                 
          Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp
          305                 310                 315                 320 
          Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro
                          325                 330                 335     
          Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu
                      340                 345                 350         
          Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His
                  355                 360                 365             
          Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu
              370                 375                 380                 
          Glu Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Phe Trp
          385                 390                 395                 400 
          Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val
                          405                 410                 415     
          Thr Val Ala Phe Ile Ile Phe Trp Val Lys Lys Val Ala Lys Lys Pro
                      420                 425                 430         
          Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe
                  435                 440                 445             
          Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr
              450                 455                 460                 
          Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg
          465                 470                 475                 480 
          Ile Ser Val Gln Glu Arg Gln
                          485         
          <![CDATA[<21]]>0> 431]]&gt;
          <br/>&lt;![CDATA[&lt;211&gt; 15]]&gt;
          <br/>&lt;![CDATA[&lt;212&gt; PRT]]&gt;
          <br/>&lt;![CDATA[&lt;213&gt; 人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt; ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 431]]&gt;
          <br/><![CDATA[Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
           1               5                  10                  15  
          <![CDATA[<210> 432]]>
          <![CDATA[<211> 165]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 432]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg
                          165 
          <![CDATA[<210> 433]]>
          <![CDATA[<211> 248]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 433]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys
                  195                 200                 205             
          Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg
              210                 215                 220                 
          Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
          225                 230                 235                 240 
          Glu Glu Glu Glu Gly Gly Cys Glu
                          245             
          <![CDATA[<210> 434]]>
          <![CDATA[<211> 239]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<22]]>3> 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 434]]&gt;
          <br/><![CDATA[Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Arg Asp Gln Arg Leu
                  195                 200                 205             
          Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro
              210                 215                 220                 
          Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile
          225                 230                 235                 
          <![CDATA[<210> 435]]>
          <![CDATA[<211> 318]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 435]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Lys Lys Gln Arg
                  195                 200                 205             
          Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala
              210                 215                 220                 
          Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro
          225                 230                 235                 240 
          Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg
                          245                 250                 255     
          Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln
                      260                 265                 270         
          His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His
                  275                 280                 285             
          Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro
              290                 295                 300                 
          Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn
          305                 310                 315             
          <![CDATA[<210> 436]]>
          <![CDATA[<211> 249]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 436]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu Leu Met Ile Ile
                  195                 200                 205             
          His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala
              210                 215                 220                 
          Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr
          225                 230                 235                 240 
          Val Val Asn Pro Lys Tyr Glu Gly Lys
                          245                 
          <![CDATA[<210> 437]]>
          <![CDATA[<211> 260]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 437]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Gln Leu Gly Leu His Ile
                  195                 200                 205             
          Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu
              210                 215                 220                 
          Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro
          225                 230                 235                 240 
          Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly
                          245                 250                 255     
          Asp Leu Trp Val
                      260 
          <![CDATA[<210> 438]]>
          <![CDATA[<211> 288]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 438]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Glu Arg Thr Met Pro Arg
                  195                 200                 205             
          Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly
              210                 215                 220                 
          Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu
          225                 230                 235                 240 
          Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro
                          245                 250                 255     
          Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln
                      260                 265                 270         
          His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
                  275                 280                 285             
          <![CDATA[<210> 439]]>
          <![CDATA[<211> 264]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 439]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Lys Val Ala Lys Lys
                  195                 200                 205             
          Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn
              210                 215                 220                 
          Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu
          225                 230                 235                 240 
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
                          245                 250                 255     
          Arg Ile Ser Val Gln Glu Arg Gln
                      260                 
          <![CDATA[<210> 440]]>
          <![CDATA[<211> 277]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<22]]>3> 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 440]]&gt;
          <br/><![CDATA[Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Arg Arg Gly Lys Thr
                  195                 200                 205             
          Asn His Tyr Gln Thr Thr Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala
              210                 215                 220                 
          Gln Val Gln Lys Pro Gly Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro
          225                 230                 235                 240 
          Ala Gln Asp Pro Cys Thr Thr Ile Tyr Val Ala Ala Thr Glu Pro Val
                          245                 250                 255     
          Pro Glu Ser Val Gln Glu Thr Asn Ser Ile Thr Val Tyr Ala Ser Val
                      260                 265                 270         
          Thr Leu Pro Glu Ser
                  275         
          <![CDATA[<210> 441]]>
          <![CDATA[<211> 380]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 441]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
                      100                 105                 110         
          Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
                  115                 120                 125             
          Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
              130                 135                 140                 
          Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
          145                 150                 155                 160 
          Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
                          165                 170                 175     
          Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
                      180                 185                 190         
          Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Lys Lys Gln Arg
                  195                 200                 205             
          Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala
              210                 215                 220                 
          Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro
          225                 230                 235                 240 
          Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg
                          245                 250                 255     
          Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln
                      260                 265                 270         
          His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His
                  275                 280                 285             
          Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro
              290                 295                 300                 
          Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Lys
          305                 310                 315                 320 
          Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro
                          325                 330                 335     
          Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala
                      340                 345                 350         
          Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp
                  355                 360                 365             
          Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              370                 375                 380 
          <![CDATA[<210> 442]]>
          <![CDATA[<211> 107]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 442]]>
          Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
           1               5                  10                  15      
          Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
                      20                  25                  30          
          Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
                  35                  40                  45              
          Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
              50                  55                  60                  
          Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
          65                  70                  75                  80  
          Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                          85                  90                  95      
          Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
                      100                 105         
          <![CDATA[<210> 443]]>
          <![CDATA[<211> 8]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 443]]>
          Pro Thr Asn Lys Ala Pro His Pro
           1               5              
          <![CDATA[<210> 444]]>
          <![CDATA[<211> 7]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 4]]>44
          Pro Thr Asn Lys Ala Pro His
           1               5          
          <![CDATA[<210> 445]]>
          <![CDATA[<211> 5]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 445]]>
          Pro Lys Gln Glu Thr
           1               5  
          <![CDATA[<210> 446]]>
          <![CDATA[<211> 5]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 446]]>
          Pro Val Gln Glu Thr
           1               5  
          <![CDATA[<210> 447]]>
          <![CDATA[<211> 5]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 447]]>
          Ser Val Gln Glu Thr
           1               5  
          <![CDATA[<210> 448]]>
          <![CDATA[<211> 8]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 448]]>
          Gln Glu Pro Gln Glu Ile Asn Phe
           1               5              
          <![CDATA[<210> 449]]>
          <![CDATA[<211> 8]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 449]]>
          Asp Tyr Lys Asp Asp Asp Asp Lys
           1               5              
          <![CDATA[<210> 450]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 450]]>
          Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser
           1               5                  10      
          <![CDATA[<210> 451]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 451]]>
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys
           1               5                  10      
          <![CDATA[<210> 452]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 452]]>
          Met Leu Ser Val Glu Glu Glu Gly Lys Glu Asp
           1               5                  10      
          <![CDATA[<210> 453]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 453]]>
          Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro
           1               5                  10      
          <![CDATA[<210> 454]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 454]]>
          Ser Thr Pro His Gln Glu Asp Gly Lys Ala Trp
           1               5                  10      
          <![CDATA[<210> 455]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 455]]>
          Thr Val Ala Val Glu Glu Thr Ile Pro Ser Thr
           1               5                  10      
          <![CDATA[<210> 456]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 456]]>
          Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala
           1               5                  10      
          <![CDATA[<210> 457]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 457]]>
          Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser
           1               5                  10      
          <![CDATA[<210> 458]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 458]]>
          Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly
           1               5                  10      
          <![CDATA[<210> 459]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 459]]>
          Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser
           1               5                  10      
          <![CDATA[<210> 460]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 460]]>
          Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
           1               5                  10      
          <![CDATA[<210> 461]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 461]]>
          Arg Thr Pro Val Gln Glu Ser Gly Tyr Pro Asp
           1               5                  10      
          <![CDATA[<210> 462]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 462]]>
          Arg Pro Pro Val Gln Glu Thr Gly Gly Gly Gly
           1               5                  10      
          <![CDATA[<210> 463]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 463]]>
          His Pro Pro Val Gln Glu Thr Gly Gly Gly Gly
           1               5                  10      
          <![CDATA[<210> 464]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 464]]>
          His Pro Pro Val Gln Glu Thr Gly Glu Gly Gly
           1               5                  10      
          <![CDATA[<210> 465]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 465]]>
          His Pro Pro Ile Gln Glu Thr Gly Asn Gly Gly
           1               5                  10      
          <![CDATA[<210> 466]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 466]]>
          Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu
           1               5                  10      
          <![CDATA[<210> 467]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 467]]>
          Ser Val Pro Ile Gln Cys Thr Asp Lys Thr Asp
           1               5                  10      
          <![CDATA[<210> 468]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 468]]>
          Pro His Pro Gln Gln Ala Thr Asp Asp Ser Ser
           1               5                  10      
          <![CDATA[<210> 469]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 469]]>
          Pro Tyr Pro Ile Gln Ala Thr Asp Gly Gly Asn
           1               5                  10      
          <![CDATA[<210> 470]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 470]]>
          Pro His Pro Ile Gln Ala Thr Asp Gly Ala Asn
           1               5                  10      
          <![CDATA[<210> 471]]>
          <![CDATA[<211> 11]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 471]]>
          Pro Tyr Pro Val Gln Ala Ser Asp Gly Gly Asp
           1               5                  10      
          <![CDATA[<210> 472]]>
          <![CDATA[<211> 8]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARI]]>ANT        
          <![CDATA[<222> (5)...(5)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 472]]>
          Pro Ser Ala Thr Xaa Gln Glu Glu
           1               5              
          <![CDATA[<210> 473]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 473]]>
          Pro Val Gln Glu
           1              
          <![CDATA[<210> 474]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 474]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 475]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 475]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 476]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 476]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Thr Gln Glu Glu
                  35              
          <![CDATA[<210> 477]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 477]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 478]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 478]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Ser Lys Glu Glu
                  35              
          <![CDATA[<210> 479]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 479]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 480]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 480]]>
          Pro Gln Glu Ile Asn Phe
           1               5      
          <![CDATA[<210> 481]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 481]]>
          Pro Gln Glu Ile Asp Phe
           1               5      
          <![CDATA[<210> 482]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400]]>> 482]]&gt;
          <br/><![CDATA[Pro Pro Glu Leu Arg Phe
           1               5      
          <![CDATA[<210> 483]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 483]]>
          Pro Glu Glu Met Ser Trp
           1               5      
          <![CDATA[<210> 484]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 484]]>
          Pro Gln Glu Asn Ser Tyr
           1               5      
          <![CDATA[<210> 485]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 485]]>
          Pro Val Glu Ser Asp Glu
           1               5      
          <![CDATA[<210> 486]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 486]]>
          Pro Glu Glu Ser Asp Glu
           1               5      
          <![CDATA[<210> 487]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<21]]>3> 人工序列]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;220&gt; ]]&gt;
          <br/>&lt;![CDATA[&lt;223&gt; 合成多肽]]&gt;
          <br/>
          <br/>&lt;![CDATA[&lt;400&gt; 487]]&gt;
          <br/><![CDATA[Pro Glu Glu Thr Asp Glu
           1               5      
          <![CDATA[<210> 488]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 488]]>
          Pro Thr Glu Asn Gly Glu
           1               5      
          <![CDATA[<210> 489]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 489]]>
          Pro Val Glu Asp Asp Glu
           1               5      
          <![CDATA[<210> 490]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 490]]>
          Pro Pro Glu Asn Tyr Glu
           1               5      
          <![CDATA[<210> 491]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 491]]>
          Pro Ser Glu Leu Arg Phe
           1               5      
          <![CDATA[<210> 492]]>
          <![CDATA[<211> 6]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (2)...(2)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIAN]]>T        
          <![CDATA[<222> (4)...(5)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (6)...(6)]]>
          <![CDATA[<223> Xaa可為任何酸性或芳香族胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 492]]>
          Pro Xaa Glu Xaa Xaa Xaa
           1               5      
          <![CDATA[<210> 493]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 493]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 494]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 494]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 495]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 495]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Glu Glu Met Ser Trp Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 496]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 496]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 497]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 497]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 498]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 498]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Ser Val Gln Glu Arg Gln
                      20                  
          <![CDATA[<210> 499]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (19)...(19)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (21)...(22)]]>
          <![CDATA[<223>Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (23)...(23)]]>
          <![CDATA[<223> Xaa可為任何酸性或芳香族胺基酸]]>
          <![CDATA[<400> 499]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Xaa Glu Xaa Xaa Xaa Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 500]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (35)...(35)]]>
          <![CDATA[<223> Xaa可為P、S、A或T]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (36)...(36)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (37)...(37)]]>
          <![CDATA[<223> Xaa可為Q或E]]>
          <![CDATA[<400> 500]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Xaa Xaa Xaa Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 501]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 501]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 502]]>
          <![CDATA[<211> 24]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (19)...(19)]]>
          <![CDATA[<223> Xaa可為P、S、A或T]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (20)...(20)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (21)...(21)]]>
          <![CDATA[<223> Xaa可為Q或E]]>
          <![CDATA[<400> 502]]>
          Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser
           1               5                  10                  15      
          Arg Ile Xaa Xaa Xaa Glu Arg Gln
                      20                  
          <![CDATA[<210> 503]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (19)...(19)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (21)...(22)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (23)...(23)]]>
          <![CDATA[<223> Xaa可為任何酸性或芳香族胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (35)...(35)]]>
          <![CDATA[<223> Xaa可為P、S、A或T]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (36)...(36)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (37)...(37)]]>
          <![CDATA[<223> Xaa可為Q或E]]>
          <![CDATA[<400> 503]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Xaa Glu Xaa Xaa Xaa Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Xaa Xaa Xaa Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 504]]>
          <![CDATA[<211> 62]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> V]]>ARIANT        
          <![CDATA[<222> (35)...(35)]]>
          <![CDATA[<223> Xaa可為P、S、A或T]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (36)...(36)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (37)...(37)]]>
          <![CDATA[<223> Xaa可為Q或E]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (57)...(57)]]>
          <![CDATA[<223> Xaa可為P、S、A或T]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (58)...(58)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (59)...(59)]]>
          <![CDATA[<223> Xaa可為Q或E]]>
          <![CDATA[<400> 504]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Xaa Xaa Xaa Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  35                  40                  45              
          Glu Asp Gly Lys Glu Ser Arg Ile Xaa Xaa Xaa Glu Arg Gln
              50                  55                  60          
          <![CDATA[<210> 505]]>
          <![CDATA[<211> 38]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (19)...(19)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (21)...(22)]]>
          <![CDATA[<223> Xaa可為任何胺基酸]]>
          <![CDATA[<220> ]]>
          <![CDATA[<221> VARIANT        ]]>
          <![CDATA[<222> (23)...(23)]]>
          <![CDATA[<223> Xaa可為任何酸性或芳香族胺基酸]]>
          <![CDATA[<400> 505]]>
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
           1               5                  10                  15      
          Glu Pro Xaa Glu Xaa Xaa Xaa Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      20                  25                  30          
          Ala Ala Pro Val Gln Glu
                  35              
          <![CDATA[<210> 506]]>
          <![CDATA[<211> 98]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 506]]>
          Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
           1               5                  10                  15      
          Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
                      20                  25                  30          
          Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
                  35                  40                  45              
          Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
              50                  55                  60                  
          Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
          65                  70                  75                  80  
          Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
                          85                  90                  95      
          Glu Val
          <![CDATA[<210> 507]]>
          <![CDATA[<211> 21]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 507]]>
          Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
           1               5                  10                  15      
          Pro Leu Ala Ser Gly
                      20      
          <![CDATA[<210> 508]]>
          <![CDATA[<211> 240]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 508]]>
          Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
                      20                  25                  30          
          Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
                  35                  40                  45              
          Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe
              50                  55                  60                  
          Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
          65                  70                  75                  80  
          Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                          85                  90                  95      
          Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly
                      100                 105                 110         
          Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile
              130                 135                 140                 
          Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser
          145                 150                 155                 160 
          Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser
                          165                 170                 175     
          Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro
                      180                 185                 190         
          Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile
                  195                 200                 205             
          Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp
              210                 215                 220                 
          Ser Lys His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
          225                 230                 235                 240 
          <![CDATA[<210> 509]]>
          <![CDATA[<211> 236]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 509]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala
           1               5                  10                  15      
          Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
                      20                  25                  30          
          Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
                  35                  40                  45              
          Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
              50                  55                  60                  
          Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
          65                  70                  75                  80  
          Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                          85                  90                  95      
          Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                      100                 105                 110         
          Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
                  115                 120                 125             
          Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser
              130                 135                 140                 
          Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg
          145                 150                 155                 160 
          Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu
                          165                 170                 175     
          Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg Phe
                      180                 185                 190         
          Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  195                 200                 205             
          Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr Thr
              210                 215                 220                 
          Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys
          225                 230                 235     
          <![CDATA[<210> 510]]>
          <![CDATA[<211> 241]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 510]]>
          Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala
           1               5                  10                  15      
          Ser Val Gln Val Ser Cys Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr
                      20                  25                  30          
          Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Glu Trp Met
                  35                  40                  45              
          Gly Val Ile Asn Pro Ser Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln
              50                  55                  60                  
          Gly Arg Val Thr Leu Thr Asn Asp Thr Ser Thr Asn Thr Val Tyr Met
          65                  70                  75                  80  
          Gln Leu Asn Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                          85                  90                  95      
          Arg Trp Ala Leu Trp Gly Asp Phe Gly Met Asp Val Trp Gly Lys Gly
                      100                 105                 110         
          Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
              130                 135                 140                 
          Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          145                 150                 155                 160 
          Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
                          165                 170                 175     
          Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala
                      180                 185                 190         
          Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  195                 200                 205             
          Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
          225                 230                 235                 240 
          Lys
          <![CDATA[<210> 511]]>
          <![CDATA[<211> 241]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 511]]>
          Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
           1               5                  10                  15      
          Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly
                      20                  25                  30          
          Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
                  35                  40                  45              
          Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
              50                  55                  60                  
          Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe
          65                  70                  75                  80  
          Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                          85                  90                  95      
          Cys Ala Arg Glu Gly Lys Asn Gly Ala Phe Asp Ile Trp Gly Gln Gly
                      100                 105                 110         
          Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
              130                 135                 140                 
          Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
          145                 150                 155                 160 
          Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys
                          165                 170                 175     
          Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val
                      180                 185                 190         
          Pro Ser Gly Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                  195                 200                 205             
          Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
              210                 215                 220                 
          Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
          225                 230                 235                 240 
          Lys
          <![CDATA[<210> 512]]>
          <![CDATA[<211> 249]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 512]]>
          Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
           1               5                  10                  15      
          Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Leu Gly Phe Tyr
                      20                  25                  30          
          Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
                  35                  40                  45              
          Val Ser Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser
              50                  55                  60                  
          Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
          65                  70                  75                  80  
          Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                          85                  90                  95      
          Tyr Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn
                      100                 105                 110         
          Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly
                  115                 120                 125             
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr
              130                 135                 140                 
          Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
          145                 150                 155                 160 
          Thr Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr Leu Ser Trp Tyr Gln
                          165                 170                 175     
          Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr
                      180                 185                 190         
          Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
                  195                 200                 205             
          Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr
              210                 215                 220                 
          Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser Asn Asn Trp His Ala
          225                 230                 235                 240 
          Phe Gly Gly Gly Thr Lys Val Glu Ile
                          245                 
          <![CDATA[<210> 513]]>
          <![CDATA[<211> 254]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 513]]>
          Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Thr Pro Ser Gln
           1               5                  10                  15      
          Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn
                      20                  25                  30          
          Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
                  35                  40                  45              
          Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala
              50                  55                  60                  
          Val Ser Val Lys Ser Arg Met Ser Ile Asn Pro Asp Thr Ser Lys Asn
          65                  70                  75                  80  
          Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val
                          85                  90                  95      
          Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr Tyr Tyr Gly Met Asp Val
                      100                 105                 110         
          Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser
                  115                 120                 125             
          Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln
              130                 135                 140                 
          Ser Ser Ser Leu Ser Ala Ser Pro Gly Ala Ser Ala Ser Leu Thr Cys
          145                 150                 155                 160 
          Thr Leu Arg Ser Gly Ile Asn Val Gly Pro Tyr Arg Ile Tyr Trp Tyr
                          165                 170                 175     
          Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr Leu Leu Asn Tyr Lys Ser
                      180                 185                 190         
          Asp Ser Asp Lys Gln Gln Gly Ser Gly Val Pro Ser Arg Phe Ser Gly
                  195                 200                 205             
          Ser Lys Asp Ala Ser Ala Asn Ala Gly Val Leu Leu Ile Ser Gly Leu
              210                 215                 220                 
          Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ile Trp His Ser Ser
          225                 230                 235                 240 
          Ala Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser
                          245                 250                 
          <![CDATA[<210> 514]]>
          <![CDATA[<211> 462]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 514]]>
          Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala
           1               5                  10                  15      
          Leu Leu Phe Pro Ser Met Ala Ser Met Gln Val Gln Leu Gln Gln Ser
                      20                  25                  30          
          Gly Ala Glu Leu Val Arg Ser Gly Thr Ser Val Lys Leu Ser Cys Thr
                  35                  40                  45              
          Ala Ser Gly Phe Asn Ile Lys Asp Ser Tyr Met His Trp Leu Arg Gln
              50                  55                  60                  
          Gly Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn
          65                  70                  75                  80  
          Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr Phe Thr
                          85                  90                  95      
          Thr Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr
                      100                 105                 110         
          Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Glu Gly Thr Pro Thr Gly
                  115                 120                 125             
          Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
              130                 135                 140                 
          Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
          145                 150                 155                 160 
          Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly
                          165                 170                 175     
          Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met
                      180                 185                 190         
          His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr
                  195                 200                 205             
          Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
              210                 215                 220                 
          Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu
          225                 230                 235                 240 
          Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr
                          245                 250                 255     
          Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Gly Ser
                      260                 265                 270         
          Gly Gly Ser Gly Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr
                  275                 280                 285             
          Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln
              290                 295                 300                 
          Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala
          305                 310                 315                 320 
          Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala
                          325                 330                 335     
          Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
                      340                 345                 350         
          Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His
                  355                 360                 365             
          Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys
              370                 375                 380                 
          His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
          385                 390                 395                 400 
          Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln
                          405                 410                 415     
          Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr
                      420                 425                 430         
          Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln
                  435                 440                 445             
          Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln
              450                 455                 460         
          <![CDATA[<210> 515]]>
          <![CDATA[<211> 180]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 515]]>
          Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn
           1               5                  10                  15      
          Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe
                      20                  25                  30          
          Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys
                  35                  40                  45              
          Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys
              50                  55                  60                  
          His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu
          65                  70                  75                  80  
          Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp
                          85                  90                  95      
          Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr
                      100                 105                 110         
          Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys
                  115                 120                 125             
          Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp
              130                 135                 140                 
          Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu
          145                 150                 155                 160 
          Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr
                          165                 170                 175     
          Asp Val Thr Leu
                      180 
          <![CDATA[<210> 516]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 516]]>
          Pro Lys Gln Glu
           1              
          <![CDATA[<210> 517]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 517]]>
          Pro Val Gln Glu
           1              
          <![CDATA[<210> 518]]>
          <![CDATA[<211> 4]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 518]]>
          Ser Val Gln Glu
           1              
          <![CDATA[<210> 519]]>
          <![CDATA[<211> 9]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 519]]>
          Gln Glu Pro Gln Glu Ile Asn Phe Pro
           1               5                  
          <![CDATA[<210> 520]]>
          <![CDATA[<211> 7]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 520]]>
          Lys Lys Pro Thr Asn Lys Ala
           1               5          
          <![CDATA[<210> 521]]>
          <![CDATA[<211> 7]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 521]]>
          Ser Arg Ile Ser Val Gln Glu
           1               5          
          <![CDATA[<210> 522]]>
          <![CDATA[<211> 132]]>
          <![CDATA[<212> PRT]]>
          <![CDATA[<213> 人工序列]]>
          <![CDATA[<220> ]]>
          <![CDATA[<223> 合成多肽]]>
          <![CDATA[<400> 522]]>
          Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn Ala Val
           1               5                  10                  15      
          Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu Phe Arg
                      20                  25                  30          
          Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys Val Val
                  35                  40                  45              
          Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr Gly Phe
              50                  55                  60                  
          Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln
          65                  70                  75                  80  
          Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val
                          85                  90                  95      
          Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile
                      100                 105                 110         
          Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly
                  115                 120                 125             
          Pro Ser Lys Pro
              130
Figure 12_A0101_SEQ_0001
Figure 12_A0101_SEQ_0002
Figure 12_A0101_SEQ_0003
Figure 12_A0101_SEQ_0004
Figure 12_A0101_SEQ_0005
Figure 12_A0101_SEQ_0006
Figure 12_A0101_SEQ_0007
Figure 12_A0101_SEQ_0008
Figure 12_A0101_SEQ_0009
Figure 12_A0101_SEQ_0010
Figure 12_A0101_SEQ_0011
Figure 12_A0101_SEQ_0012
Figure 12_A0101_SEQ_0013
Figure 12_A0101_SEQ_0014
Figure 12_A0101_SEQ_0015
Figure 12_A0101_SEQ_0016
Figure 12_A0101_SEQ_0017
Figure 12_A0101_SEQ_0018
Figure 12_A0101_SEQ_0019
Figure 12_A0101_SEQ_0020
Figure 12_A0101_SEQ_0021
Figure 12_A0101_SEQ_0022
Figure 12_A0101_SEQ_0023
Figure 12_A0101_SEQ_0024
Figure 12_A0101_SEQ_0025
Figure 12_A0101_SEQ_0026
Figure 12_A0101_SEQ_0027
Figure 12_A0101_SEQ_0028
Figure 12_A0101_SEQ_0029
Figure 12_A0101_SEQ_0030
Figure 12_A0101_SEQ_0031
Figure 12_A0101_SEQ_0032
Figure 12_A0101_SEQ_0033
Figure 12_A0101_SEQ_0034
Figure 12_A0101_SEQ_0035
Figure 12_A0101_SEQ_0036
Figure 12_A0101_SEQ_0037
Figure 12_A0101_SEQ_0038
Figure 12_A0101_SEQ_0039
Figure 12_A0101_SEQ_0040
Figure 12_A0101_SEQ_0041
Figure 12_A0101_SEQ_0042
Figure 12_A0101_SEQ_0043
Figure 12_A0101_SEQ_0044
Figure 12_A0101_SEQ_0045
Figure 12_A0101_SEQ_0046
Figure 12_A0101_SEQ_0047
Figure 12_A0101_SEQ_0048
Figure 12_A0101_SEQ_0049
Figure 12_A0101_SEQ_0050
Figure 12_A0101_SEQ_0051
Figure 12_A0101_SEQ_0052
Figure 12_A0101_SEQ_0053
Figure 12_A0101_SEQ_0054
Figure 12_A0101_SEQ_0055
Figure 12_A0101_SEQ_0056
Figure 12_A0101_SEQ_0057
Figure 12_A0101_SEQ_0058
Figure 12_A0101_SEQ_0059
Figure 12_A0101_SEQ_0060
Figure 12_A0101_SEQ_0061
Figure 12_A0101_SEQ_0062
Figure 12_A0101_SEQ_0063
Figure 12_A0101_SEQ_0064
Figure 12_A0101_SEQ_0065
Figure 12_A0101_SEQ_0066
Figure 12_A0101_SEQ_0067
Figure 12_A0101_SEQ_0068
Figure 12_A0101_SEQ_0069
Figure 12_A0101_SEQ_0070
Figure 12_A0101_SEQ_0071
Figure 12_A0101_SEQ_0072
Figure 12_A0101_SEQ_0073
Figure 12_A0101_SEQ_0074
Figure 12_A0101_SEQ_0075
Figure 12_A0101_SEQ_0076
Figure 12_A0101_SEQ_0077
Figure 12_A0101_SEQ_0078
Figure 12_A0101_SEQ_0079
Figure 12_A0101_SEQ_0080
Figure 12_A0101_SEQ_0081
Figure 12_A0101_SEQ_0082
Figure 12_A0101_SEQ_0083
Figure 12_A0101_SEQ_0084
Figure 12_A0101_SEQ_0085
Figure 12_A0101_SEQ_0086
Figure 12_A0101_SEQ_0087
Figure 12_A0101_SEQ_0088
Figure 12_A0101_SEQ_0089
Figure 12_A0101_SEQ_0090
Figure 12_A0101_SEQ_0091
Figure 12_A0101_SEQ_0092
Figure 12_A0101_SEQ_0093
Figure 12_A0101_SEQ_0094
Figure 12_A0101_SEQ_0095
Figure 12_A0101_SEQ_0096
Figure 12_A0101_SEQ_0097
Figure 12_A0101_SEQ_0098
Figure 12_A0101_SEQ_0099
Figure 12_A0101_SEQ_0100
Figure 12_A0101_SEQ_0101
Figure 12_A0101_SEQ_0102
Figure 12_A0101_SEQ_0103
Figure 12_A0101_SEQ_0104
Figure 12_A0101_SEQ_0105
Figure 12_A0101_SEQ_0106
Figure 12_A0101_SEQ_0107
Figure 12_A0101_SEQ_0108
Figure 12_A0101_SEQ_0109
Figure 12_A0101_SEQ_0110
Figure 12_A0101_SEQ_0111
Figure 12_A0101_SEQ_0112
Figure 12_A0101_SEQ_0113
Figure 12_A0101_SEQ_0114
Figure 12_A0101_SEQ_0115
Figure 12_A0101_SEQ_0116
Figure 12_A0101_SEQ_0117
Figure 12_A0101_SEQ_0118
Figure 12_A0101_SEQ_0119
Figure 12_A0101_SEQ_0120
Figure 12_A0101_SEQ_0121
Figure 12_A0101_SEQ_0122
Figure 12_A0101_SEQ_0123
Figure 12_A0101_SEQ_0124
Figure 12_A0101_SEQ_0125
Figure 12_A0101_SEQ_0126
Figure 12_A0101_SEQ_0127
Figure 12_A0101_SEQ_0128
Figure 12_A0101_SEQ_0129
Figure 12_A0101_SEQ_0130
Figure 12_A0101_SEQ_0131
Figure 12_A0101_SEQ_0132
Figure 12_A0101_SEQ_0133
Figure 12_A0101_SEQ_0134
Figure 12_A0101_SEQ_0135
Figure 12_A0101_SEQ_0136
Figure 12_A0101_SEQ_0137
Figure 12_A0101_SEQ_0138
Figure 12_A0101_SEQ_0139
Figure 12_A0101_SEQ_0140
Figure 12_A0101_SEQ_0141
Figure 12_A0101_SEQ_0142
Figure 12_A0101_SEQ_0143
Figure 12_A0101_SEQ_0144
Figure 12_A0101_SEQ_0145
Figure 12_A0101_SEQ_0146
Figure 12_A0101_SEQ_0147
Figure 12_A0101_SEQ_0148
Figure 12_A0101_SEQ_0149
Figure 12_A0101_SEQ_0150
Figure 12_A0101_SEQ_0151
Figure 12_A0101_SEQ_0152
Figure 12_A0101_SEQ_0153
Figure 12_A0101_SEQ_0154
Figure 12_A0101_SEQ_0155
Figure 12_A0101_SEQ_0156
Figure 12_A0101_SEQ_0157
Figure 12_A0101_SEQ_0158
Figure 12_A0101_SEQ_0159
Figure 12_A0101_SEQ_0160
Figure 12_A0101_SEQ_0161
Figure 12_A0101_SEQ_0162
Figure 12_A0101_SEQ_0163
Figure 12_A0101_SEQ_0164
Figure 12_A0101_SEQ_0165
Figure 12_A0101_SEQ_0166
Figure 12_A0101_SEQ_0167
Figure 12_A0101_SEQ_0168
Figure 12_A0101_SEQ_0169
Figure 12_A0101_SEQ_0170
Figure 12_A0101_SEQ_0171
Figure 12_A0101_SEQ_0172
Figure 12_A0101_SEQ_0173
Figure 12_A0101_SEQ_0174
Figure 12_A0101_SEQ_0175
Figure 12_A0101_SEQ_0176
Figure 12_A0101_SEQ_0177
Figure 12_A0101_SEQ_0178
Figure 12_A0101_SEQ_0179
Figure 12_A0101_SEQ_0180
Figure 12_A0101_SEQ_0181
Figure 12_A0101_SEQ_0182
Figure 12_A0101_SEQ_0183
Figure 12_A0101_SEQ_0184
Figure 12_A0101_SEQ_0185
Figure 12_A0101_SEQ_0186
Figure 12_A0101_SEQ_0187
Figure 12_A0101_SEQ_0188
Figure 12_A0101_SEQ_0189
Figure 12_A0101_SEQ_0190
Figure 12_A0101_SEQ_0191
Figure 12_A0101_SEQ_0192
Figure 12_A0101_SEQ_0193
Figure 12_A0101_SEQ_0194
Figure 12_A0101_SEQ_0195
Figure 12_A0101_SEQ_0196
Figure 12_A0101_SEQ_0197
Figure 12_A0101_SEQ_0198
Figure 12_A0101_SEQ_0199
Figure 12_A0101_SEQ_0200
Figure 12_A0101_SEQ_0201
Figure 12_A0101_SEQ_0202
Figure 12_A0101_SEQ_0203
Figure 12_A0101_SEQ_0204
Figure 12_A0101_SEQ_0205
Figure 12_A0101_SEQ_0206
Figure 12_A0101_SEQ_0207
Figure 12_A0101_SEQ_0208
Figure 12_A0101_SEQ_0209
Figure 12_A0101_SEQ_0210
Figure 12_A0101_SEQ_0211
Figure 12_A0101_SEQ_0212
Figure 12_A0101_SEQ_0213
Figure 12_A0101_SEQ_0214
Figure 12_A0101_SEQ_0215
Figure 12_A0101_SEQ_0216
Figure 12_A0101_SEQ_0217
Figure 12_A0101_SEQ_0218
Figure 12_A0101_SEQ_0219
Figure 12_A0101_SEQ_0220
Figure 12_A0101_SEQ_0221
Figure 12_A0101_SEQ_0222
Figure 12_A0101_SEQ_0223
Figure 12_A0101_SEQ_0224
Figure 12_A0101_SEQ_0225
Figure 12_A0101_SEQ_0226
Figure 12_A0101_SEQ_0227
Figure 12_A0101_SEQ_0228
Figure 12_A0101_SEQ_0229
Figure 12_A0101_SEQ_0230
Figure 12_A0101_SEQ_0231
Figure 12_A0101_SEQ_0232
Figure 12_A0101_SEQ_0233
Figure 12_A0101_SEQ_0234
Figure 12_A0101_SEQ_0235
Figure 12_A0101_SEQ_0236
Figure 12_A0101_SEQ_0237
Figure 12_A0101_SEQ_0238
Figure 12_A0101_SEQ_0239
Figure 12_A0101_SEQ_0240
Figure 12_A0101_SEQ_0241
Figure 12_A0101_SEQ_0242
Figure 12_A0101_SEQ_0243
Figure 12_A0101_SEQ_0244
Figure 12_A0101_SEQ_0245
Figure 12_A0101_SEQ_0246
Figure 12_A0101_SEQ_0247
Figure 12_A0101_SEQ_0248
Figure 12_A0101_SEQ_0249
Figure 12_A0101_SEQ_0250
Figure 12_A0101_SEQ_0251
Figure 12_A0101_SEQ_0252
Figure 12_A0101_SEQ_0253
Figure 12_A0101_SEQ_0254
Figure 12_A0101_SEQ_0255
Figure 12_A0101_SEQ_0256
Figure 12_A0101_SEQ_0257
Figure 12_A0101_SEQ_0258
Figure 12_A0101_SEQ_0259
Figure 12_A0101_SEQ_0260
Figure 12_A0101_SEQ_0261
Figure 12_A0101_SEQ_0262
Figure 12_A0101_SEQ_0263
Figure 12_A0101_SEQ_0264
Figure 12_A0101_SEQ_0265
Figure 12_A0101_SEQ_0266
Figure 12_A0101_SEQ_0267
Figure 12_A0101_SEQ_0268
Figure 12_A0101_SEQ_0269
Figure 12_A0101_SEQ_0270
Figure 12_A0101_SEQ_0271
Figure 12_A0101_SEQ_0272
Figure 12_A0101_SEQ_0273
Figure 12_A0101_SEQ_0274
Figure 12_A0101_SEQ_0275
Figure 12_A0101_SEQ_0276
Figure 12_A0101_SEQ_0277
Figure 12_A0101_SEQ_0278
Figure 12_A0101_SEQ_0279
Figure 12_A0101_SEQ_0280
Figure 12_A0101_SEQ_0281
Figure 12_A0101_SEQ_0282
Figure 12_A0101_SEQ_0283
Figure 12_A0101_SEQ_0284
Figure 12_A0101_SEQ_0285
Figure 12_A0101_SEQ_0286
Figure 12_A0101_SEQ_0287
Figure 12_A0101_SEQ_0288
Figure 12_A0101_SEQ_0289
Figure 12_A0101_SEQ_0290
Figure 12_A0101_SEQ_0291
Figure 12_A0101_SEQ_0292
Figure 12_A0101_SEQ_0293
Figure 12_A0101_SEQ_0294
Figure 12_A0101_SEQ_0295
Figure 12_A0101_SEQ_0296
Figure 12_A0101_SEQ_0297
Figure 12_A0101_SEQ_0298
Figure 12_A0101_SEQ_0299
Figure 12_A0101_SEQ_0300
Figure 12_A0101_SEQ_0301
Figure 12_A0101_SEQ_0302
Figure 12_A0101_SEQ_0303
Figure 12_A0101_SEQ_0304
Figure 12_A0101_SEQ_0305
Figure 12_A0101_SEQ_0306
Figure 12_A0101_SEQ_0307
Figure 12_A0101_SEQ_0308
Figure 12_A0101_SEQ_0309
Figure 12_A0101_SEQ_0310
Figure 12_A0101_SEQ_0311
Figure 12_A0101_SEQ_0312
Figure 12_A0101_SEQ_0313
Figure 12_A0101_SEQ_0314
Figure 12_A0101_SEQ_0315
Figure 12_A0101_SEQ_0316
Figure 12_A0101_SEQ_0317
Figure 12_A0101_SEQ_0318
Figure 12_A0101_SEQ_0319
Figure 12_A0101_SEQ_0320
Figure 12_A0101_SEQ_0321
Figure 12_A0101_SEQ_0322
Figure 12_A0101_SEQ_0323
Figure 12_A0101_SEQ_0324
Figure 12_A0101_SEQ_0325
Figure 12_A0101_SEQ_0326
Figure 12_A0101_SEQ_0327
Figure 12_A0101_SEQ_0328
Figure 12_A0101_SEQ_0329
Figure 12_A0101_SEQ_0330
Figure 12_A0101_SEQ_0331
Figure 12_A0101_SEQ_0332
Figure 12_A0101_SEQ_0333
Figure 12_A0101_SEQ_0334
Figure 12_A0101_SEQ_0335
Figure 12_A0101_SEQ_0336
Figure 12_A0101_SEQ_0337
Figure 12_A0101_SEQ_0338
Figure 12_A0101_SEQ_0339
Figure 12_A0101_SEQ_0340
Figure 12_A0101_SEQ_0341
Figure 12_A0101_SEQ_0342
Figure 12_A0101_SEQ_0343
Figure 12_A0101_SEQ_0344
Figure 12_A0101_SEQ_0345
Figure 12_A0101_SEQ_0346
Figure 12_A0101_SEQ_0347
Figure 12_A0101_SEQ_0348
Figure 12_A0101_SEQ_0349
Figure 12_A0101_SEQ_0350
Figure 12_A0101_SEQ_0351
Figure 12_A0101_SEQ_0352
Figure 12_A0101_SEQ_0353
Figure 12_A0101_SEQ_0354
Figure 12_A0101_SEQ_0355
Figure 12_A0101_SEQ_0356
Figure 12_A0101_SEQ_0357
Figure 12_A0101_SEQ_0358
Figure 12_A0101_SEQ_0359
Figure 12_A0101_SEQ_0360
Figure 12_A0101_SEQ_0361
Figure 12_A0101_SEQ_0362
Figure 12_A0101_SEQ_0363
Figure 12_A0101_SEQ_0364
Figure 12_A0101_SEQ_0365
Figure 12_A0101_SEQ_0366
Figure 12_A0101_SEQ_0367
Figure 12_A0101_SEQ_0368
Figure 12_A0101_SEQ_0369
Figure 12_A0101_SEQ_0370
Figure 12_A0101_SEQ_0371
Figure 12_A0101_SEQ_0372
Figure 12_A0101_SEQ_0373
Figure 12_A0101_SEQ_0374
Figure 12_A0101_SEQ_0375
Figure 12_A0101_SEQ_0376
Figure 12_A0101_SEQ_0377
Figure 12_A0101_SEQ_0378
Figure 12_A0101_SEQ_0379
Figure 12_A0101_SEQ_0380
Figure 12_A0101_SEQ_0381
Figure 12_A0101_SEQ_0382
Figure 12_A0101_SEQ_0383
Figure 12_A0101_SEQ_0384
Figure 12_A0101_SEQ_0385
Figure 12_A0101_SEQ_0386
Figure 12_A0101_SEQ_0387
Figure 12_A0101_SEQ_0388
Figure 12_A0101_SEQ_0389
Figure 12_A0101_SEQ_0390
Figure 12_A0101_SEQ_0391
Figure 12_A0101_SEQ_0392
Figure 12_A0101_SEQ_0393
Figure 12_A0101_SEQ_0394
Figure 12_A0101_SEQ_0395
Figure 12_A0101_SEQ_0396
Figure 12_A0101_SEQ_0397
Figure 12_A0101_SEQ_0398
Figure 12_A0101_SEQ_0399
Figure 12_A0101_SEQ_0400
Figure 12_A0101_SEQ_0401
Figure 12_A0101_SEQ_0402
Figure 12_A0101_SEQ_0403
Figure 12_A0101_SEQ_0404
Figure 12_A0101_SEQ_0405
Figure 12_A0101_SEQ_0406
Figure 12_A0101_SEQ_0407
Figure 12_A0101_SEQ_0408
Figure 12_A0101_SEQ_0409
Figure 12_A0101_SEQ_0410
Figure 12_A0101_SEQ_0411
Figure 12_A0101_SEQ_0412
Figure 12_A0101_SEQ_0413
Figure 12_A0101_SEQ_0414
Figure 12_A0101_SEQ_0415
Figure 12_A0101_SEQ_0416
Figure 12_A0101_SEQ_0417
Figure 12_A0101_SEQ_0418
Figure 12_A0101_SEQ_0419
Figure 12_A0101_SEQ_0420
Figure 12_A0101_SEQ_0421
Figure 12_A0101_SEQ_0422
Figure 12_A0101_SEQ_0423
Figure 12_A0101_SEQ_0424
Figure 12_A0101_SEQ_0425
Figure 12_A0101_SEQ_0426
Figure 12_A0101_SEQ_0427
Figure 12_A0101_SEQ_0428
Figure 12_A0101_SEQ_0429
Figure 12_A0101_SEQ_0430
Figure 12_A0101_SEQ_0431
Figure 12_A0101_SEQ_0432
Figure 12_A0101_SEQ_0433
Figure 12_A0101_SEQ_0434
Figure 12_A0101_SEQ_0435
Figure 12_A0101_SEQ_0436
Figure 12_A0101_SEQ_0437
Figure 12_A0101_SEQ_0438
Figure 12_A0101_SEQ_0439
Figure 12_A0101_SEQ_0440
Figure 12_A0101_SEQ_0441
Figure 12_A0101_SEQ_0442
Figure 12_A0101_SEQ_0443
Figure 12_A0101_SEQ_0444
Figure 12_A0101_SEQ_0445
Figure 12_A0101_SEQ_0446
Figure 12_A0101_SEQ_0447
Figure 12_A0101_SEQ_0448
Figure 12_A0101_SEQ_0449
Figure 12_A0101_SEQ_0450
Figure 12_A0101_SEQ_0451
Figure 12_A0101_SEQ_0452
Figure 12_A0101_SEQ_0453
Figure 12_A0101_SEQ_0454
Figure 12_A0101_SEQ_0455
Figure 12_A0101_SEQ_0456
Figure 12_A0101_SEQ_0457
Figure 12_A0101_SEQ_0458
Figure 12_A0101_SEQ_0459
Figure 12_A0101_SEQ_0460
Figure 12_A0101_SEQ_0461
Figure 12_A0101_SEQ_0462
Figure 12_A0101_SEQ_0463
Figure 12_A0101_SEQ_0464
Figure 12_A0101_SEQ_0465
Figure 12_A0101_SEQ_0466
Figure 12_A0101_SEQ_0467
Figure 12_A0101_SEQ_0468
Figure 12_A0101_SEQ_0469
Figure 12_A0101_SEQ_0470
Figure 12_A0101_SEQ_0471
Figure 12_A0101_SEQ_0472
Figure 12_A0101_SEQ_0473
Figure 12_A0101_SEQ_0474
Figure 12_A0101_SEQ_0475
Figure 12_A0101_SEQ_0476
Figure 12_A0101_SEQ_0477
Figure 12_A0101_SEQ_0478
Figure 12_A0101_SEQ_0479
Figure 12_A0101_SEQ_0480
Figure 12_A0101_SEQ_0481
Figure 12_A0101_SEQ_0482
Figure 12_A0101_SEQ_0483
Figure 12_A0101_SEQ_0484
Figure 12_A0101_SEQ_0485
Figure 12_A0101_SEQ_0486
Figure 12_A0101_SEQ_0487
Figure 12_A0101_SEQ_0488
Figure 12_A0101_SEQ_0489
Figure 12_A0101_SEQ_0490
Figure 12_A0101_SEQ_0491
Figure 12_A0101_SEQ_0492
Figure 12_A0101_SEQ_0493
Figure 12_A0101_SEQ_0494
Figure 12_A0101_SEQ_0495
Figure 12_A0101_SEQ_0496
Figure 12_A0101_SEQ_0497
Figure 12_A0101_SEQ_0498
Figure 12_A0101_SEQ_0499
Figure 12_A0101_SEQ_0500
Figure 12_A0101_SEQ_0501
Figure 12_A0101_SEQ_0502
Figure 12_A0101_SEQ_0503
Figure 12_A0101_SEQ_0504
Figure 12_A0101_SEQ_0505
Figure 12_A0101_SEQ_0506
Figure 12_A0101_SEQ_0507
Figure 12_A0101_SEQ_0508
Figure 12_A0101_SEQ_0509
Figure 12_A0101_SEQ_0510
Figure 12_A0101_SEQ_0511
Figure 12_A0101_SEQ_0512
Figure 12_A0101_SEQ_0513
Figure 12_A0101_SEQ_0514
Figure 12_A0101_SEQ_0515
Figure 12_A0101_SEQ_0516
Figure 12_A0101_SEQ_0517
Figure 12_A0101_SEQ_0518
Figure 12_A0101_SEQ_0519
Figure 12_A0101_SEQ_0520
Figure 12_A0101_SEQ_0521
Figure 12_A0101_SEQ_0522
Figure 12_A0101_SEQ_0523
Figure 12_A0101_SEQ_0524
Figure 12_A0101_SEQ_0525
Figure 12_A0101_SEQ_0526
Figure 12_A0101_SEQ_0527
Figure 12_A0101_SEQ_0528
Figure 12_A0101_SEQ_0529
Figure 12_A0101_SEQ_0530
Figure 12_A0101_SEQ_0531
Figure 12_A0101_SEQ_0532
Figure 12_A0101_SEQ_0533
Figure 12_A0101_SEQ_0534
Figure 12_A0101_SEQ_0535
Figure 12_A0101_SEQ_0536
Figure 12_A0101_SEQ_0537
Figure 12_A0101_SEQ_0538
Figure 12_A0101_SEQ_0539
Figure 12_A0101_SEQ_0540
Figure 12_A0101_SEQ_0541
Figure 12_A0101_SEQ_0542
Figure 12_A0101_SEQ_0543
Figure 12_A0101_SEQ_0544
Figure 12_A0101_SEQ_0545
Figure 12_A0101_SEQ_0546
Figure 12_A0101_SEQ_0547
Figure 12_A0101_SEQ_0548
Figure 12_A0101_SEQ_0549
Figure 12_A0101_SEQ_0550
Figure 12_A0101_SEQ_0551
Figure 12_A0101_SEQ_0552
Figure 12_A0101_SEQ_0553
Figure 12_A0101_SEQ_0554
Figure 12_A0101_SEQ_0555
Figure 12_A0101_SEQ_0556
Figure 12_A0101_SEQ_0557
Figure 12_A0101_SEQ_0558
Figure 12_A0101_SEQ_0559
Figure 12_A0101_SEQ_0560
Figure 12_A0101_SEQ_0561
Figure 12_A0101_SEQ_0562
Figure 12_A0101_SEQ_0563
Figure 12_A0101_SEQ_0564
Figure 12_A0101_SEQ_0565
Figure 12_A0101_SEQ_0566
Figure 12_A0101_SEQ_0567
Figure 12_A0101_SEQ_0568
Figure 12_A0101_SEQ_0569
Figure 12_A0101_SEQ_0570
Figure 12_A0101_SEQ_0571
Figure 12_A0101_SEQ_0572
Figure 12_A0101_SEQ_0573
Figure 12_A0101_SEQ_0574
Figure 12_A0101_SEQ_0575
Figure 12_A0101_SEQ_0576
Figure 12_A0101_SEQ_0577
Figure 12_A0101_SEQ_0578
Figure 12_A0101_SEQ_0579
Figure 12_A0101_SEQ_0580
Figure 12_A0101_SEQ_0581
Figure 12_A0101_SEQ_0582
Figure 12_A0101_SEQ_0583
Figure 12_A0101_SEQ_0584
Figure 12_A0101_SEQ_0585
Figure 12_A0101_SEQ_0586
Figure 12_A0101_SEQ_0587
Figure 12_A0101_SEQ_0588
Figure 12_A0101_SEQ_0589
Figure 12_A0101_SEQ_0590
Figure 12_A0101_SEQ_0591
Figure 12_A0101_SEQ_0592
Figure 12_A0101_SEQ_0593
Figure 12_A0101_SEQ_0594
Figure 12_A0101_SEQ_0595
Figure 12_A0101_SEQ_0596
Figure 12_A0101_SEQ_0597

Claims (43)

  1. 一種嵌合共刺激抗原受體(CoStAR)，其包括： 結合至癌胚抗原(CEA)之細胞外結合結構域或結合至間皮素(MSLN)之細胞外結合結構域，其操作性連接至跨膜結構域，及 第一信號傳導結構域及ICOS之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及NTRK1之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及DAP10之細胞內結構域或其信號傳導片段，或 第一信號傳導結構域及CD40信號傳導結構域或其信號傳導片段，或 第一信號傳導結構域及TRAF2/TRAF3序列、TRAF6序列、TRAF2序列或IProx序列中之一或多者。
  2. 如請求項1之CoStAR，其中該第一信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。
  3. 如請求項1之CoStAR，其中該CoStAR包括第二信號傳導結構域。
  4. 如請求項3之CoStAR，其中該第二信號傳導結構域包括CD2、CD9、CD26、CD27、CD28、CD29、CD38、CD40、CD43、CD46、CD49d、CD55、CD73、CD81、CD82、CD99、CD100、CD134 (OX40)、CD137 (41BB)、CD150 (SLAM)、CD270 (HVEM)、CD278 (ICOS)、CD357 (GITR)或EphB6之信號傳導結構域或信號傳導片段。
  5. 如請求項1之CoStAR，其中該CD40信號傳導片段包括SH3模體(KPTNKAPH, SEQ ID NO:35)、TRAF2模體(PKQE, SEQ ID NO:36, PVQE, SEQ ID NO:37, SVQE, SEQ ID NO:38)、TRAF6模體(QEPQEINFP, SEQ ID NO:39)、PKA模體(KKPTNKA, SEQ ID NO:40, SRISVQE, SEQ ID NO:41)或其組合，或係全長CD40細胞內結構域。
  6. 如請求項2之CoStAR，其中該第一信號傳導結構域包括全長共刺激結構域。
  7. 如請求項1之CoStAR，其中該細胞外結合結構域藉由連接體及/或間隔體操作性連接至該跨膜結構域。
  8. 如請求項7之CoStAR，其中該連接體包括約5至約20個胺基酸。
  9. 如請求項7之CoStAR，其中該連接體或間隔體包括約10至約250個胺基酸。
  10. 如請求項1之CoStAR，其中該CoStAR包括第二細胞外結合結構域。
  11. 如請求項10之CoStAR，其中該第二細胞外結合結構域包括來自CD8、CD28或ICOS之配體結合結構域。
  12. 如請求項1之CoStAR，其中該跨膜結構域包括來自CD28、CD8、ICOS、DAP10或NTRK之跨膜結構域。
  13. 如請求項1之CoStAR，其中該跨膜結構域包括SEQ ID NO:20、SEQ ID NO:21或SEQ ID NO:22之跨膜結構域序列。
  14. 如請求項1之CoStAR，其中該細胞外結合結構域包括scFv、肽、抗體重鏈可變結構域、抗體輕鏈可變結構域或CEA配體或MSLN配體。
  15. 如請求項1至14中任一項之CoStAR，其進一步在C末端處包括信號傳導結構域。
  16. 如請求項1至14中任一項之CoStAR，其進一步包括N末端信號肽。
  17. 如請求項16之CoStAR，其中該N末端信號肽包括抑瘤素M (OSM)、CD8α、CD2、介白素-2 (IL-2)、顆粒球-巨噬球群落刺激因子(GM-CSF)或人類IgGκ之信號肽。
  18. 一種核酸，其編碼如請求項1至17中任一項之CoStAR。
  19. 一種載體，其包括如請求項18之核酸。
  20. 一種細胞，其表現如請求項1至16中任一項之CoStAR。
  21. 如請求項20之細胞，其中該細胞包括α-β T細胞、γ-δ T細胞、T調控細胞、TIL、NKT細胞或NK細胞。
  22. 如請求項20之細胞，其中該細胞共表現CAR或TCR。
  23. 一種製備如請求項20之細胞之方法，其包括使用如請求項19之載體轉導或轉染細胞之步驟。
  24. 一種製備表現如請求項1至16中任一項之CoStAR之細胞群體之方法，其包括 i)檢測該CoStAR在經如請求項19之載體轉染或轉導之細胞之表面上的表現；及 ii)選擇鑑別為表現該CoStAR之細胞。
  25. 一種細胞群體，其富集如請求項1至16中任一項之CoStAR之細胞表現。
  26. 一種治療個體之疾病之方法，其包括向該個體投與如請求項20至22中任一項之細胞或如請求項25之細胞群體之步驟。
  27. 一種融合蛋白，其中該融合蛋白包括： 對CEA具有特異性之結合結構域，其連接至下一結構； 跨膜結構域，其連接至下一結構； ICOS結構域，其連接至下一結構； CD40信號傳導結構域。
  28. 一種融合蛋白，其中該融合蛋白包括： 對MSLN具有特異性之結合結構域，其連接至下一結構； 跨膜結構域，其連接至下一結構； CD28結構域，其連接至下一結構； CD40信號傳導結構域。
  29. 一種融合蛋白，其中該融合蛋白包括： 第一序列，其與SEQ ID NO: 12至少70%一致； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 518至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。
  30. 一種融合蛋白，其中該融合蛋白包括： 第一序列，其與SEQ ID NO: 186-191中之任一者至少70%一致； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 25至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。
  31. 一種融合蛋白，其中該融合蛋白包括： HCDR1，其係SEQ ID NO: 12中之HCDR1； HCDR2，其係SEQ ID NO: 12中之HCDR2； HCDR3，其係SEQ ID NO: 12中之HCDR3； LCDR1，其係SEQ ID NO: 12中之LCDR1； LCDR2，其係SEQ ID NO: 12中之LCDR2； LCDR3，其係SEQ ID NO: 12中之HCDR3， 其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 515至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。
  32. 如請求項31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。
  33. 如請求項31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。
  34. 如請求項31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 515至少70%一致之ICOS序列。
  35. 如請求項31之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。
  36. 一種融合蛋白，其中該融合蛋白包括： HCDR1，其係SEQ ID NO: 186-191中之HCDR1； HCDR2，其係SEQ ID NO: 186-191中之HCDR2； HCDR3，其係SEQ ID NO: 186-191中之HCDR3； LCDR1，其係SEQ ID NO: 186-191中之LCDR1； LCDR2，其係SEQ ID NO: 186-191中之LCDR2； LCDR3，其係SEQ ID NO: 186-191中之HCDR3 其中該等LCDR中之1、2、3、4、5或6者可包含1、2或3個點突變； 第二序列，其係跨膜結構域； 第三序列，其與SEQ ID NO: 25至少70%一致；及 第四序列，其與SEQ ID NO: 32至少70%一致。
  37. 如請求項36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 1至少70%一致之信號肽序列。
  38. 如請求項36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 18至少70%一致之連接體序列。
  39. 如請求項36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 19至少70%一致之CD28 TM序列。
  40. 如請求項36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 25至少70%一致之CD28序列。
  41. 如請求項36之融合蛋白，其中該融合蛋白進一步包括與SEQ ID NO: 32至少70%一致之CD40序列。
  42. 一種細胞療法之方法，其包括： a)鑑別個體，其中該個體患有表現MSLN或CEA之癌症；及 b)投與如前述請求項中任一項之CoSTaR或融合蛋白中之任一者或多者。
  43. 一種治療個體之表現MSLN或CEA之癌症之方法，該方法包括： a)鑑別個體，其中該個體患有表現MSLN或CEA之癌症；及 b)投與如前述請求項中任一項之CoSTaR或融合蛋白中之任一者或多者。
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Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5872215A (en) 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
GB9324807D0 (en) 1993-12-03 1994-01-19 Cancer Res Campaign Tech Tumour antibody
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
AU723073B2 (en) 1994-10-05 2000-08-17 Immunomedics Inc. CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies
WO1996013584A1 (en) 1994-11-01 1996-05-09 Targeted Genetics Corporation Chimeric receptors for the generation of selectively-activatable th-independent cytotoxic t cells
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
CA2386270A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
MXPA02008265A (es) 2000-02-24 2004-09-10 Xcyte Therapies Inc Concentracion y estimulacion simultanea de calulas.
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
AU2001275474A1 (en) 2000-06-12 2001-12-24 Akkadix Corporation Materials and methods for the control of nematodes
JP2005502598A (ja) 2001-06-07 2005-01-27 メドベット・サイエンス・プロプライエタリー・リミテッド サイトカインを介する細胞活性を調節することによる治療方法およびそのために有用な物質
CA2453986A1 (en) * 2001-07-18 2003-01-30 Merck Patent Gesellschaft Mit Beschraenkter Haftung Glycoprotein vi fusion proteins
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US7232888B2 (en) 2002-07-01 2007-06-19 Massachusetts Institute Of Technology Antibodies against tumor surface antigens
WO2005086875A2 (en) 2004-03-11 2005-09-22 City Of Hope A humanized anti-cea t84.66 antibody and uses thereof
EP1765988B1 (en) 2004-05-27 2017-09-20 The Trustees of The University of Pennsylvania Novel artificial antigen presenting cells and uses therefor
US20070036773A1 (en) 2005-08-09 2007-02-15 City Of Hope Generation and application of universal T cells for B-ALL
US8357783B2 (en) 2008-03-27 2013-01-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human anti-mesothelin monoclonal antibodies
US9486498B2 (en) 2008-05-19 2016-11-08 Case Western Reserve University Method of treating CD40-mediated diseases
WO2010111282A1 (en) 2009-03-24 2010-09-30 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Anti-mesothelin antibodies
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
KR20140004174A (ko) 2011-01-18 2014-01-10 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 치료를 위한 조성물 및 방법
JP6334398B2 (ja) 2011-07-29 2018-05-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スイッチ共刺激受容体
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
US9359447B2 (en) 2012-03-23 2016-06-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mesothelin chimeric antigen receptors
CN105026429B (zh) 2012-08-21 2018-09-25 美国政府(由卫生和人类服务部的部长所代表) 间皮素结构域-特异性单克隆抗体及其用途
RU2020124583A (ru) 2012-10-02 2020-08-03 Мемориал Слоан-Кеттеринг Кэнсер Сентер Композиции и способы для иммунотерапии
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
ES2898270T3 (es) 2013-02-06 2022-03-04 Celgene Corp Linfocitos T modificados con especificidad mejorada
CN105209065B (zh) 2013-03-14 2020-07-31 贝里坤制药股份有限公司 控制t细胞增殖的方法
CN116478927A (zh) 2013-12-19 2023-07-25 诺华股份有限公司 人间皮素嵌合抗原受体及其用途
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
US10865243B2 (en) 2014-07-16 2020-12-15 Hinrich Abken Chimeric antigen receptor and its use
ES2781175T3 (es) 2014-07-31 2020-08-31 Novartis Ag Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico
MA41538A (fr) 2014-10-17 2017-12-26 Baylor College Medicine Cellules immunitaires bipartites et tripartites de signalisation
JP6917896B2 (ja) 2015-03-05 2021-08-18 フレッド ハッチンソン キャンサー リサーチ センター 免疫調節性融合タンパク質およびその使用
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
MA44314A (fr) * 2015-11-05 2018-09-12 Juno Therapeutics Inc Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées
US20200281973A1 (en) 2016-03-04 2020-09-10 Novartis Ag Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
WO2017176525A1 (en) 2016-04-04 2017-10-12 Promab Biotechnologies, Inc. Car having replicated binding motifs in a co-stimulatory domain
US12083148B2 (en) 2017-02-22 2024-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. IL13Ra2-binding chimeric antigen receptors
CN110650743B (zh) 2017-03-13 2023-12-29 波赛达治疗公司 用于选择性消除和替换造血干细胞的组合物和方法
TW201837175A (zh) 2017-03-13 2018-10-16 美商凱特製藥公司 用於黑色素瘤之嵌合抗原受體及其用途
US11725210B2 (en) 2017-03-17 2023-08-15 Fred Hutchinson Cancer Center Immunomodulatory fusion proteins and uses thereof
JP7538601B2 (ja) 2017-04-26 2024-08-22 ユーリカ セラピューティックス， インコーポレイテッド キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用
WO2018208849A1 (en) 2017-05-09 2018-11-15 Bellicum Pharmaceuticals, Inc. Methods to augment or alter signal transduction
CN117866095A (zh) 2018-07-09 2024-04-12 普众发现医药科技(上海)有限公司 叶酸受体α特异性抗体
GB201900858D0 (en) * 2019-01-22 2019-03-13 Price Nicola Kaye Receptors providing targeted costimulation for adoptive cell therapy
EP4028526A4 (en) 2019-09-11 2023-08-30 Migal Galilee Research Institute Ltd. A CHIMERIC ANTIGEN RECEPTOR COMPRISING A CD40 CYTOPLASMATIC DOMAIN AND USES THEREOF
JP2023534808A (ja) 2020-07-17 2023-08-14 インスティル バイオ （ユーケイ） リミテッド 養子細胞療法のための標的共刺激を提供する受容体
WO2022150831A1 (en) 2021-01-07 2022-07-14 Innovative Cellular Therapeutics Holdings, Ltd. Car cells and polyspecific binding molecules for treating solid tumor
TW202306997A (zh) 2021-06-16 2023-02-16 英商英斯特生物科技有限公司 用於在過繼細胞療法中提供標靶共刺激之受體
EP4370213A1 (en) 2021-07-16 2024-05-22 Instil Bio (Uk) Limited Chimeric molecules providing targeted costimulation for adoptive cell therapy
US20230227576A1 (en) 2022-01-20 2023-07-20 Instil Bio (Uk) Limited Receptors providing targeted costimulation for adoptive cell therapy

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