CN112088008B - 修饰细胞的扩增及其用途 - Google Patents

修饰细胞的扩增及其用途 Download PDF

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CN112088008B
CN112088008B CN201980007920.7A CN201980007920A CN112088008B CN 112088008 B CN112088008 B CN 112088008B CN 201980007920 A CN201980007920 A CN 201980007920A CN 112088008 B CN112088008 B CN 112088008B
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CN112088008A (zh
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蒲程飞
曹志远
吴昭
肖磊
毛丽
毕茂
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Shanghai Xuxu Technology Co ltd
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Zhejiang Xuxu Technology Co ltd
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Abstract

本公开涉及体内和/或体外增强T细胞应答和/或CAR细胞扩增的组合物和方法。例如，细胞可包含第一嵌合抗原受体(CAR)和第二CAR，其中所述第一CAR的结合结构域结合第一抗原，并且所述第二CAR的结合结构域结合第二抗原。所述第一抗原不同于所述第二抗原。在实施方案中，所述第一CAR可识别血细胞的表面分子。

Description

修饰细胞的扩增及其用途
相关申请的交叉引用
本申请要求2018年9月28日提交的美国申请16/146,218；2018年8月23日提交的美国临时申请62/721,791；2018年6月27日提交的美国临时申请62/690,892；2018年4月18日提交的美国临时申请62/659,233；2018年6月19日提交的美国临时申请62/687,059；2018年5月31日提交的美国临时申请62/678,836；2018年4月17日提交的美国临时申请62/659,114；2018年2月6日提交的美国临时申请62/626,781；2018年1月26日提交的美国临时申请62/622,601；以及2018年1月12日提交的美国临时申请62/616,609；2018年1月11日提交的美国临时申请62/616,079的权益，所述美国临时申请特此以引用的方式整体并入。
序列表信息
2018年12月18日左右创建的标题为“Sequence Listing.txt”的计算机可读文本文件，文件大小为约949KB，包含本申请的序列表，并且特此以引用的方式整体并入。
技术领域
本公开涉及用于扩增修饰的细胞(包括修饰的T细胞)的组合物和方法，以及其在疾病(包括癌症)治疗中的用途。
背景技术
嵌合抗原受体(CAR)T细胞疗法在诸如B-ALL/CLL/淋巴瘤的癌症中取得了良好的临床疗效。然而，对实体瘤的治疗进展相对缓慢。为了使CAR T细胞疗法有效，在肿瘤治疗中长期维持患者体内的CAR T细胞对于患者的预后至关重要。例如，如果可以维持CAR T细胞长期存在，则该技术可以有效减少肿瘤复发。
癌症被称为恶性肿瘤，其涉及异常细胞生长，并有可能侵袭或扩散到身体的其他部位。在人类中，存在一百多种癌症。一个实例是存在于乳房上皮组织中的乳癌。由于乳癌细胞失去了正常细胞的特征，因此失去了乳癌细胞之间的联系。一旦癌细胞脱落，它们就会通过血液和/或淋巴系统扩散到整个身体，因此会危及生命。目前，乳癌已成为对女性身心健康的常见威胁之一。虽然已证明免疫疗法(例如，CAR T)对治疗癌症有效，但是仍需要改进免疫疗法以使得对某种癌症诸如实体瘤更有效。
发明内容
由于患者可以在B细胞的耗竭中存活，因此患者的B细胞可用于通过使用第一抗原结合结构域扩增患者体内的CAR T细胞。因此，可在患者体内及时扩增更多的CAR T细胞，从而增加CAR T细胞的效力。患者体内及时扩增的CAR T细胞可增加CAR T细胞接触肿瘤细胞的机会，尤其是具有与第二CAR结合的抗原的实体瘤细胞。
本公开描述了基因修饰的细胞，诸如T细胞，其包含两种不同的抗原结合结构域：用于扩增修饰细胞的第一抗原结合结构域，和用于杀死靶细胞(诸如肿瘤细胞)的第二抗原结合结构域。例如，第一抗原结合结构域与B细胞的表面标志物(诸如表面抗原)结合，并且第二抗原结合结构域与肿瘤细胞的靶抗原结合。两种抗原结合结构域可在相同CAR分子上，不同CAR分子上或CAR和T细胞受体(TCR)上。在实施方案中，第一结合结构域结合白细胞的细胞表面分子，而第二结合结构域结合不同于白细胞的细胞表面分子的抗原即肿瘤抗原。
两种抗原结合结构域可以由单种核酸或多于一种核酸编码。在实施方案中，细胞包括修饰的T细胞，例如CAR T细胞。在实施方案中，靶细胞包括实体瘤细胞。
本公开还描述了编码第一CAR和第二CAR或TCR的一种或多种核酸。第一CAR包含第一抗原结合结构域，并且第二CAR或TCR包含第二抗原结合结构域。在实施方案中，第一CAR和第二CAR或TCR表达为单独的多肽，并由至少两种单独的核酸编码。在实施方案中，单个CAR含有至少两种抗原结合结构域，并由单种核酸编码。本文描述的实施方案涉及包含本文所述的核酸的载体，并且涉及包含本文所述的核酸的细胞。
此外，本公开描述了响应于第一CAR和第二CAR或TCR的引入而进行的细胞因子释放。在实施方案中，细胞因子是IL-6和IFN-γ。
本发明内容既不旨在标识所要求保护的主题的关键特征或必要特征，也不旨在用于限制所要求保护的主题的范围。
附图说明
参照附图描述具体实施方式。在不同附图中使用相同的参考号指示相似或相同的项目。
图1是示例性CAR分子和一部分细胞膜的示意图。
图2是包括两个CAR分子和具有两个不同CAR分子的T细胞结构的核酸构建体的示意图。
图3是示出包含两个CAR分子的细胞膜的示例性部分的示意图。
图4是示出包含双特异性CAR分子的细胞膜的示例性部分的示意图。
图5是示出包含双特异性CAR分子和T细胞受体(TCR)的细胞膜的示例性部分的示意图。
图6示出了表达抗CD19 CAR和抗MUC1 CAR的T细胞的流式细胞术检测结果。
图7示出了表达抗CD19 CAR和抗MUC1 CAR的T细胞的功能分析。
图8示出了T细胞对与各种底物细胞共培养的响应的直方图。
图9示出了T细胞对与各种底物细胞共培养的响应的直方图。
图10示出了抗TSHR CAR分子在T细胞上的表达的流式细胞分析(由单个活细胞门控)。构建抗TSHR CAR T细胞，并通过流式细胞术检测CAR分子的表达。与未转导的T细胞相比，观察到CAR分子的表达。
图11示出了TSHR在T细胞上的过表达的流式细胞分析(由单个活细胞门控)。慢病毒载体用于构建抗原过度表达的T细胞(TSHR)。观察到TSHR分子在T细胞表面上的表达(左边为IgG，而右边为抗TSHR FITC)。
图12示出了小鼠外周血中的细胞因子释放(IL-2)。
图13示出了小鼠外周血中的细胞因子释放(IFN-γ)。
图14示出了小鼠外周血中的细胞因子释放(IL-4)。
图15示出了与对照相比，小鼠外周血中的CAR/CD3细胞比率增加。
图16示出了CAR T细胞输注到患者A后，随时间(天数)推移CAR分子拷贝数的变化。
图17示出了CAR T细胞输注到患者B后，随时间(天数)推移CAR分子拷贝数的变化。
图18示出了CAR T细胞输注到患者C后，随时间(天数)推移CAR分子拷贝数的变化。
图19示出了CAR T细胞输注到患者D后，随时间(天数)推移CAR分子拷贝数的变化。
图20示出了CAR T细胞输注到患者E后，随时间(天数)推移CAR分子拷贝数的变化。
图21示出了靶向基因的示例性外显子的一对ZFN的实例。
图22、图23、图24和图25示出了靶向各种基因片段并通过PCR扩增的ZFN的测序结果。观察到ZFN的双重测序信号，并且双重测序信号的底部用黑框圈起来，这表明靶向基因被引入了突变。双重测序信号的密度越高，编辑效率越高。
图26、图27、图28、图29和图30示出了靶向各种基因片段并通过PCR扩增的ZFN的测序结果。观察到ZFN的多重测序信号，并且多重测序信号的底部用黑框圈起来，这表明靶向基因被引入了突变。多重测序信号的密度越高，编辑效率越高。测序结果上方的标记代表相应的ZFN组合，并且由ZFN鉴定的靶序列用黑框圈起来。
图31示出了用或不用gRNA处理的情况下293T细胞的B2m表达的流式细胞术。
图32、图33、图34和图35示出了不同组中人白细胞/鼠白细胞的流式细胞术检测结果。小鼠外周血裂解后，这些细胞衍生自所有活细胞。横轴代表hCD45的相应染色的荧光强度，并且纵轴代表mCD45的相应染色的荧光强度。
图36、图37、图38和图39示出了T细胞/人白细胞的流式细胞术检测结果。这些细胞衍生自图32-35中的人白细胞hCD45，横轴代表CD3的相应染色的荧光强度，并且纵轴代表CD19的相应染色的荧光强度。
图40示出了每只小鼠的细胞因子IL-2和IFN-γ的释放。从小鼠获得外周血样品，并且上清液提供在表13中。
图41、图42、图43和图44示出了小鼠外周血T细胞中的CD8/CD4比例。这些细胞衍生自图36-39中的CD3，横轴代表CD4的相应染色的荧光强度，并且纵轴代表CD8的相应染色的荧光强度。具体结果提供在表14中。
图45示出了T细胞/小鼠白细胞的结果。从表19中的统计和数据可以看出，NT组、2407组和Nalm6+2407+1204组的T细胞/小鼠中的白细胞比率相似，而2407+1204组的T细胞/小鼠中的白细胞比率高于其他四组。
图46示出了CD8/CD4的结果。从表20中的统计数据可以看出，四组CD8/CD4的比率没有显著差异。
图47示出了来自小鼠上清液的外周血样品的细胞因子数据。
图48示出了响应于用不同细胞输注的组，小鼠的肿瘤体积变化。
图49示出了CAR T细胞输注到患者F后，随时间(天数)推移CAR分子拷贝数的变化。CAR分子拷贝数包括CAR总拷贝数和各个CAR(即抗CD19 CAR和抗tMUC1 CAR)拷贝数。
图50示出了患者F的细胞因子释放结果。
图51示出了患者C与患者F之间的IL-6释放比较。
图52示出了患者C与患者F之间的IFN-γ释放比较。
具体实施方式
除非另外定义，否则本文所用的所有技术术语和科学术语具有与本公开所属领域中的普通技术人员所通常理解的相同的含义。尽管可在本公开的实践或测试中使用与本文描述的那些方法和材料类似或等效的任何方法和材料，但还是描述了优选的方法和材料。为了本公开的目的，以下术语定义如下。
本文使用冠词“一个/种(a/an)”是指一个或多于一个(即，至少一个)物品的语法对象。举例来说，“一种要素”意指一种要素或多于一种要素。
“大约”意指数量、水平、值、数目、频率、百分比、尺寸、大小、量、重量或长度相对于参考数量、水平、值、数目、频率、百分比、尺寸、大小、量、重量或长度变化多达20％、15％、10％、9％、8％、7％、6％、5％、4％、3％、2％或1％。
如本文所用，术语“激活”是指已被充分刺激以诱导可检测的细胞增殖的细胞状态。激活也可以与诱导的细胞因子产生和可检测的效应子功能相关。术语“激活的T细胞”尤其是指正在进行细胞分裂的T细胞。
术语“抗体”的使用范围最广，是指单克隆抗体(包括全长单克隆抗体)、多克隆抗体、多特异性抗体(例如，双特异性抗体)和抗体片段，只要它们表现出所需的生物学活性或功能即可。本公开中的抗体可以以各种形式存在，包括例如多克隆抗体、单克隆抗体、Fv、Fab和F(ab)2，以及单链抗体和人源化抗体(Harlow等人,1999,In:Using Antibodies:ALaboratory Manual,Cold Spring Harbor Laboratory Press,NY；Harlow等人,1989,In:Antibodies:A Laboratory Manual,Cold Spring Harbor,New York；Houston等人,1988,Proc.Natl.Acad.Sci.USA 85:5879-5883；Bird等人,1988,Science 242:423-426)。
术语“抗体片段”是指全长抗体的一部分，例如，抗体的抗原结合或可变区。抗体片段的其他实例包括Fab、Fab’、F(ab’)2和Fv片段；双抗体；线性抗体；单链抗体分子；以及由抗体片段形成的多特异性抗体。
术语“Fv”是指包含完整抗原识别和抗原结合位点的最小抗体片段。该片段由紧密、非共价缔合的一个重链可变区结构域和一个轻链可变区结构域的二聚体组成。通过这两个结构域的折叠，产生了六个高变环(3个环来自H链，3个环来自L链)，其贡献了用于抗原结合的氨基酸残基并赋予抗体抗原结合特异性。然而，即使单个可变结构域(或仅包含对抗原具有特异性的三个互补决定区(CDR)的Fv的一半)也具有识别和结合抗原的能力，尽管其亲和力低于整个结合位点(二聚体)。
如本文所用的“抗体重链”是指以其天然存在的构型存在于所有抗体分子中的两种类型的多肽链中的较大者。如本文所用的“抗体轻链”是指以其天然存在的构型存在于所有抗体分子中的两种类型的多肽链中的较小者。κ和λ轻链是指两种主要的抗体轻链同种型。
术语“合成抗体”是指使用重组DNA技术生成的抗体，诸如例如由噬菌体表达的抗体。所述术语还包括通过合成编码抗体的DNA分子和表达DNA分子以获得抗体或获得编码抗体的氨基酸而生成的抗体。使用本领域可用和众所周知的技术来获得合成DNA。
术语“抗原”是指引起免疫应答的分子，其可涉及抗体产生或特异性免疫能力细胞的激活或两者。抗原包括任何大分子，所述大分子包括所有蛋白质或肽，或衍生自重组或基因组DNA的分子。例如，包含编码引发免疫应答的蛋白质或肽的核苷酸序列或部分核苷酸序列的DNA，因此编码如本文所用的术语“抗原”。抗原不必仅由基因的全长核苷酸序列编码。抗原可以从生物样品中生成、合成或衍生自生物样品，所述生物样品包括组织样品、肿瘤样品、细胞或生物流体。
如本文所用，术语“抗肿瘤作用”是指与肿瘤体积减小、肿瘤细胞数减少、转移数减少、肿瘤细胞增殖减少、肿瘤细胞存活减少、具有肿瘤细胞的受试者的预期寿命增加或与癌性病状相关的各种生理症状改善相关的生物作用。首先，也可以通过肽、多核苷酸、细胞和抗体在预防肿瘤发生方面的能力来表现出“抗肿瘤作用”。
术语“自体抗原”是指被免疫系统误认为是外来的抗原。自体抗原包括细胞蛋白、磷蛋白、细胞表面蛋白、细胞脂质、核酸、糖蛋白，包括细胞表面受体。
术语“自体的”用于描述衍生自受试者的材料，其随后被重新引入同一受试者中。
术语“同种异体的”用于描述衍生自相同物种的不同受试者的移植物。作为实例，供体受试者可以是相关或不相关的或受体受试者，但是供体受试者具有与受体受试者相似的免疫系统标志物。
术语“异种的”用于描述衍生自不同物种的受试者的移植物。作为实例，供体受试者与受体受试者来自不同的物种，并且供体受试者和受体受试者可以是遗传学和免疫学上不相容的。
术语“癌症”用于指特征在于异常细胞快速且不受控制的生长的疾病。癌细胞可以局部扩散，或通过血流和淋巴系统扩散至身体的其他部位。各种癌症的实例包括乳癌、前列腺癌、卵巢癌、子宫颈癌、皮肤癌、胰腺癌、结肠直肠癌、肾癌、肝癌、脑癌、淋巴瘤、白血病、肺癌等。
在整个说明书中，除非上下文另外要求，否则词语“包含(comprise)”、“包括(includes)”和“包括(including)”将被理解为暗示包括所述步骤或要素或步骤或要素的组，但不排除任何其他步骤或要素或步骤或要素的组。
短语“由......组成”意指包括并且限于短语“由......组成”之后的任何内容。因此，短语“由......组成”指示所列出的要素是必需或强制性的，并且可不存在其他要素。
短语“基本上由......组成”意指包括在短语之后列出的任何要素，并且可以包括不干扰或不影响本公开中针对所列要素所指定的活动或动作的其他要素。因此，短语“基本上由......组成”指示所列出的要素是必需的或强制性的，但是其他要素是可选的，并且取决于它们是否影响所列要素的活动或动作，可以存在或可以不存在。
术语“互补的”和“互补性”是指通过碱基配对规则关联在一起的多核苷酸(即核苷酸序列)。例如，序列“A-G-T”与序列“T-C-A”互补。互补性可以是“部分的”，其中仅一些核酸的碱基根据碱基配对规则匹配，或在核酸之间可以存在“完全的”或“全部的”互补性。核酸链之间的互补程度对核酸链之间的杂交效率和强度有重要作用。
术语“对应于(corresponds to)”或“对应于(corresponding to)”是指(a)具有与参考多核苷酸序列的全部或一部分基本上相同或互补或编码与肽或蛋白质中的氨基酸序列相同的氨基酸序列的核苷酸序列的多核苷酸；或(b)具有与参考肽或蛋白质中的氨基酸序列基本上相同的氨基酸序列的肽或多肽。
术语“共刺激配体”是指抗原呈递细胞(例如，APC、树突状细胞、B细胞等)上的分子，其特异性结合T细胞上的同源共刺激分子，从而提供除了由例如TCR/CD3复合物与载有肽的MHC分子结合提供的主要信号外的一种信号，所述信号介导T细胞应答，包括增殖、激活、分化和其他细胞应答的至少一种。共刺激配体可以包括B7-1(CD80)、B7-2(CD86)、PD-L1、PD-L2、4-1BBL、OX40L、诱导型共刺激配体(ICOS-L)、细胞间粘附分子(ICAM)、CD30L、CD40、CD70、CD83、HLA-G、MICA、MICB、HVEM、淋巴毒素β受体、3/TR6、ILT3、ILT4、HVEM、CD7的配体、结合Toll配体受体的激动剂或抗体以及与B7-H3特异性结合的配体。共刺激配体还尤其包括与T细胞上存在的共刺激分子特异性结合的激动剂或抗体，诸如CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3以及特异性结合CD83的配体。
术语“共刺激分子”是指T细胞上的同源结合配偶体，其与共刺激配体特异性结合，从而介导T细胞的共刺激应答，诸如增殖。共刺激分子包括MHC I类分子、BTLA和Toll样受体。
术语“共刺激信号”是指与主要信号(诸如TCR/CD3连接)结合，导致T细胞增殖和/或关键分子上调或下调的信号。术语“疾病”和“病状”可以互换使用，或可以不同，因为特定的疾病或病状可能没有已知的致病物(因此病因尚未得到解决)，因此它还不是公认的疾病，但仅是一种不良病状或综合症，其中临床医生已鉴定出或多或少的特定症状的集合。术语“疾病”是受试者的健康状态，其中受试者不能维持体内平衡，并且其中如果疾病没有得到改善，则受试者的健康继续恶化。相比之下，受试者的“病症”是一种健康状态，其中动物能够维持体内平衡，但是其中动物的健康状态要比没有病症的情况下不利。如果不及时治疗，病症不一定会导致动物健康状态进一步下降。
术语“有效”是指足以实现期望的、预期的或意图的结果。例如，在治疗背景下的“有效量”可以是足以产生治疗或预防益处的化合物的量。
术语“编码”是指多核苷酸诸如基因、cDNA或mRNA中的特定核苷酸序列在生物过程中用作合成其他聚合物和大分子的模板的固有特性，所述生物过程具有确定的核苷酸序列(即，rRNA、tRNA和mRNA)或确定的氨基酸序列以及由此产生的生物特性。因此，如果对应于基因的mRNA的转录和翻译在细胞或其他生物系统中产生蛋白质，则所述基因编码所述蛋白质。其核苷酸序列与mRNA序列相同(除了用“U”代替“T”以外)并且通常提供在序列表中的编码链以及用作基因或cDNA转录的模板的非编码链可被称为编码所述基因或cDNA的蛋白质或其他产物。
术语“外源的”是指并非天然存在于野生型细胞或生物体中，但通常通过分子生物学技术引入细胞中的分子。外源多核苷酸的实例包括编码所需蛋白质的载体、质粒和/或人造核酸构建体。关于多核苷酸和蛋白质，术语“内源的”或“天然的”是指可以在给定的野生型细胞或生物体中发现的天然存在的多核苷酸或氨基酸序列。同样，通过分子生物学技术从第一生物体分离并转移至第二生物体的特定多核苷酸序列通常被认为是相对于第二生物体的“外源”多核苷酸或氨基酸序列。在具体实施方案中，可以通过分子生物学技术将多核苷酸序列“引入”已经含有这种多核苷酸序列的微生物中，例如，以产生原本天然存在的多核苷酸序列的一个或多个其他拷贝，从而促进编码多肽的过表达。
术语“表达”是指由其启动子驱动的特定核苷酸序列的转录和/或翻译。
术语“表达载体”是指包含重组多核苷酸的载体，所述重组多核苷酸包含可操作连接至待表达的核苷酸序列的表达控制序列。表达载体包括足够的用于表达的顺式作用要素；用于表达的其他要素可以由宿主细胞提供或提供在体外表达系统中。表达载体包括本领域已知的并入重组多核苷酸的所有载体，诸如粘粒、质粒(例如，裸露的或包含在脂质体中)和病毒(例如，慢病毒、逆转录病毒、腺病毒和腺相关病毒)。
术语“同源的”是指当两个比较的序列中的一个位置被相同的碱基或氨基酸单体亚基占据时，两个多肽之间或两个多核苷酸之间的序列相似性或序列同一性，例如，如果两个DNA分子中的每个中的一个位置被腺嘌呤占据，则分子在所述位置上是同源的。两个序列之间的同源性百分比是两个序列享有的匹配或同源位置数除以所比较的位置数×100的函数。例如，如果两个序列中10个位置中有6个是匹配或同源的，则两个序列是60％同源的。举例来说，DNA序列ATTGCC和TATGGC享有50％的同源性。当比对两个序列时进行比较，以得到最大同源性。
术语“免疫球蛋白”或“Ig”是指用作抗体的一类蛋白质。包括在此类蛋白质中的五个成员是IgA、IgG、IgM、IgD和IgE。IgA是存在于身体分泌物，诸如唾液、眼泪、母乳、胃肠道分泌物和呼吸道与泌尿生殖道的粘液分泌物中的一抗。IgG是最常见的循环抗体。在大多数受试者中，IgM是初次免疫应答中产生的主要免疫球蛋白。它是凝集、补体固定和其他抗体应答中最有效的免疫球蛋白，并且对于防御细菌和病毒很重要。IgD是不具有已知抗体功能但可以充当抗原受体的免疫球蛋白。IgE是通过暴露于过敏原时，引起肥大细胞和嗜碱性粒细胞释放介体而介导速发型超敏反应的免疫球蛋白。
术语“分离的”是指基本上或实质上不含在其天然状态下通常伴随其的组分的材料。所述材料可以是细胞或大分子，诸如蛋白质或核酸。例如，如本文所用的“分离的多核苷酸”是指已从以天然存在状态的方式位于其侧翼的序列中纯化的多核苷酸，例如已从通常与片段相邻的序列中去除的DNA片段。或者，如本文所用的“分离的肽”或“分离的多肽”等是指从其天然细胞环境以及从其与细胞的其他组分的缔合中体外分离和/或纯化肽或多肽分子。
术语“基本上纯化的”是指基本上不含在其天然状态下通常与其缔合的组分的材料。例如，基本上纯化的细胞是指已从以其天然存在或天然状态的方式通常缔合的其他细胞类型中分离的细胞。在一些情况下，基本上纯化的细胞群是指同质的细胞群。在其他情况下，该术语简单地是指已从以其天然状态的方式与其天然缔合的细胞中分离的细胞。在实施方案中，细胞在体外培养。在实施方案中，细胞并非在体外培养。
在本公开的上下文中，使用了以下常见存在的核酸碱基的缩写。“A”是指腺苷，“C”是指胞嘧啶，“G”是指鸟苷，“T”是指胸苷，并且“U”是指尿苷。
除非另有说明，否则“编码氨基酸序列的核苷酸序列”包括彼此为简并形式并且编码相同氨基酸序列的所有核苷酸序列。短语编码蛋白质或RNA核苷酸序列也可以包括内含子，其程度为编码蛋白质的核苷酸序列在某些形式中可以包含一个或多个内含子。
术语“慢病毒”是指逆转录病毒科的一个属。慢病毒在逆转录病毒中是独特的，其能够感染非分裂细胞；它们可以将大量的遗传信息递送到宿主细胞的DNA中，因此它们是基因递送载体的最有效方法之一。HIV、SIV和FIV都是慢病毒的实例。衍生自慢病毒的载体提供了在体内实现显著水平的基因转移的手段。
术语“调节”是指与不存在治疗或化合物的情况下受试者中的反应水平相比，和/或与其他相同但未治疗的受试者中的反应水平相比，介导受试者中反应水平的可检测的增加或降低。所述术语涵盖干扰和/或影响天然信号或反应，从而在受试者、优选地人中介导有益的治疗反应。
当核酸与另一个核酸序列处于功能关系时，所述核酸是“可操作连接的”。例如，如果前序列或分泌前导序列的DNA表达为参与多肽分泌的前蛋白，则所述DNA可操作地连接至多肽的DNA；如果启动子或增强子影响序列的转录，则所述启动子或增强子可操作地连接至编码序列；或如果核糖体结合位点被定位以便于翻译，则所述核糖体结合位点可操作地连接至编码序列。
术语“在转录控制下”是指启动子可操作地连接至多核苷酸并相对于多核苷酸并处于正确的位置和方向，以控制由RNA聚合酶进行的转录开始和多核苷酸表达。
术语“过度表达的”肿瘤抗原或肿瘤抗原的“过度表达”旨在指示相对于来自特定组织或器官的正常细胞中的表达水平，来自患者的所述组织或器官中的疾病区域(例如实体瘤)的细胞中肿瘤抗原的异常表达水平。可以通过本领域已知的标准测定来确定患有特征在于肿瘤抗原过表达的实体瘤或血液恶性肿瘤的患者。
实体瘤是通常不包含囊肿或液体区域的异常组织块。实体瘤可以是良性或恶性的。不同类型的实体瘤根据形成它们的细胞类型而命名(诸如肉瘤、癌瘤和淋巴瘤)。实体瘤诸如肉瘤和癌瘤的实例包括纤维肉瘤、粘肉肉瘤、脂肪肉瘤、软骨肉瘤、骨肉瘤和其他肉瘤、滑膜瘤、间皮瘤、尤因氏肿瘤、平滑肌肉瘤、横纹肌肉瘤、结肠癌、淋巴性恶性肿瘤、胰腺癌、乳癌、肺癌、卵巢癌、前列腺癌、肝细胞癌、鳞状细胞癌、基底细胞癌、腺癌、汗腺癌、甲状腺髓样癌、乳头状甲状腺癌、嗜铬细胞瘤皮脂腺癌、乳头状癌、乳头状腺癌、髓样癌、支气管癌、肾细胞癌、肝癌、胆管癌、绒毛膜癌、威尔姆斯瘤、宫颈癌、睾丸肿瘤、精原细胞瘤、膀胱癌、黑色素瘤和CNS(中枢神经系统)肿瘤(诸如神经胶质瘤(诸如脑干神经胶质瘤和混合神经胶质瘤)、胶质母细胞瘤(也称为多形性成胶质细胞瘤)、星形胶质细胞瘤、CNS淋巴瘤、生殖细胞瘤、髓母细胞瘤、神经鞘瘤、颅咽管瘤、室管膜瘤、松果体瘤、血管母细胞瘤、听神经瘤、少突胶质细胞瘤、脑膜瘤、神经母细胞瘤、视网膜母细胞瘤和脑转移)。
实体瘤抗原是在实体瘤上表达的抗原。在实施方案中，实体瘤抗原也在健康组织上低水平表达。实体瘤抗原及其相关疾病肿瘤的实例提供在表1中。
表1
术语组合物的“肠胃外施用”包括例如皮下(s.c.)、静脉内(i.v.)、肌内(i.m.)、胸骨内注射或输注技术。
术语“患者”、“受试者”和“个体”等在本文可互换使用，并且是指适用于本文描述的方法的任何人、动物或活生物体。在某些非限制性实施方案中，患者、受试者或个体是人或动物。在实施方案中，术语“受试者”旨在包括在其中可以引发免疫应答的活生物体(例如，哺乳动物)。受试者的实例包括人和动物，诸如狗、猫、小鼠、大鼠及其转基因物种。
需要治疗或其有需要的受试者包括患有需要治疗的疾病、病状或病症的受试者。其有需要的受试者还包括需要治疗以预防疾病、病状或病症的受试者。
术语“多核苷酸”或“核酸”是指mRNA、RNA、cRNA、rRNA、cDNA或DNA。所述术语通常是指长度至少为10个碱基的聚合形式核苷酸，核糖核苷酸或脱氧核苷酸或修饰形式的任一类型核苷酸。所述术语包括所有形式的核酸，包括单链和双链形式的核酸。
术语“多核苷酸变体”和“变体”等是指与参考多核苷酸序列显示基本序列同一性的多核苷酸或在下文定义的严格条件下与参考序列杂交的多核苷酸。这些术语还涵盖通过添加、缺失或替换至少一个核苷酸而与参考多核苷酸区分开的多核苷酸。因此，术语“多核苷酸变体”和“变体”包括其中一个或多个核苷酸已被添加或缺失或被不同核苷酸代替的多核苷酸。就这一点而言，本领域众所周知，可以对参考多核苷酸进行某些改变，包括突变、添加、缺失和替换，从而使改变后的多核苷酸保留参考多核苷酸的生物功能或活性或相对于参考多核苷酸具有增加的活性(即优化的)。多核苷酸变体包括例如与本文描述的参考多核苷酸序列具有至少50％(和至少51％至至少99％以及其间的所有整数百分比，例如90％、95％或98％)序列同一性的多核苷酸。术语“多核苷酸变体”和“变体”还包括天然存在的等位基因变体和直系同源物。
术语“多肽”、“多肽片段”、“肽”和“蛋白质”在本文中可互换使用，是指氨基酸残基的聚合物及其变体和合成类似物。因此，这些术语适用于氨基酸聚合物，其中一个或多个氨基酸残基是合成的非天然存在的氨基酸，诸如相应天然存在的氨基酸的化学类似物，以及适用于天然存在的氨基酸聚合物。在某些方面，多肽可以包括酶促多肽或“酶”，其通常催化各种化学反应(即，增加其速率)。
术语“多肽变体”是指通过添加、缺失或替换至少一个氨基酸残基而与参考多肽序列区分开的多肽。在某些实施方案中，多肽变体通过一个或多个替换而与参考多肽区分开，所述一个或多个替换可以是保守的或非保守的。在某些实施方案中，多肽变体包含保守替换，并且就这一点而言，在本领域中众所周知，可以将一些氨基酸改变为具有大致相似特性的其他氨基酸，而不改变多肽活性的性质。多肽变体还涵盖其中一个或多个氨基酸已被添加或缺失或被不同氨基酸残基代替的多肽。
术语“启动子”是指由细胞的合成机制识别或引入合成机制，开始多核苷酸序列的特异性转录所需要的DNA序列。术语“表达控制序列”是指在特定宿主生物体中表达可操作连接的编码序列所必需的DNA序列。适用于原核生物的控制序列例如包括启动子，任选地操纵子序列和核糖体结合位点。已知真核细胞利用启动子、聚腺苷酸化信号和增强子。
术语“结合(bind)”、“结合(binds)”或“与......相互作用”是指识别并粘附于样品或生物体中第二分子但基本上不识别或粘附于样品中其他结构无关分子的分子。如本文所用关于抗体的术语“特异性结合”，是指识别特异性抗原但基本上不识别或结合样品中其他分子的抗体。例如，特异性结合来自一种物种的抗原的抗体也可以结合来自一种或多种物种的抗原。但是，这种种间反应性本身并不会改变抗体的特异性分类。在另一个实例中，特异性结合抗原的抗体也可以结合不同等位基因形式的抗原。然而，这种交叉反应性本身并不会改变抗体的特异性分类。在一些情况下，术语“特异性结合(specific binding)”或“特异性结合(specifically binding)”可用于指抗体、蛋白质或肽与第二化学物种的相互作用，意味着相互作用取决于化学物种上的特定结构(例如，抗原决定簇或表位)存在；例如，抗体识别并结合特定的蛋白质结构，而不是结合任何蛋白质。如果抗体对表位“A”具有特异性，则在包含标记“A”和抗体的反应中存在包含表位A(或游离、未标记的A)的分子将减少与抗体结合的标记A的量。
“统计学上显著的”意指结果不太可能是偶然发生的。统计学显著性可以通过本领域已知的任何方法确定。常用的显著性度量包括p值，所述p值是在虚假设为真时观察到的事件发生的频率或概率。如果获得的p值小于显著性水平，则拒绝虚假设。在简单情况下，显著性水平被定义为0.05或更小的p值。“减少”或“降低”或“较少”的量通常是“统计学上显著的”或生理上显著的量，并且可包括约1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2、2.5、3、3.5、4、4.5、5、6、7、8、9、10、15、20、30、40或50或更多倍(例如，100、500、1000倍)(包括介于1和大于1之间的所有整数和小数点，例如1.5、1.6、1.7、1.8等)本文描述的量或水平的减少量。
术语“刺激”是指由刺激分子(例如，TCR/CD3复合物)与其同源配体结合从而介导信号转导事件，诸如经由TCR/CD3复合物进行的信号转导而诱导的初次应答。刺激可以介导某些分子表达的改变，诸如TGF-β的下调和/或细胞骨架结构的再组织。
术语“刺激分子”是指T细胞上与存在于抗原呈递细胞上的同源刺激配体特异性结合的分子。例如，来源于刺激分子的功能性信号传导结构域是与T细胞受体复合物缔合的ζ链。
术语“刺激配体”是指以下配体，所述配体当存在于抗原呈递细胞(例如，APC、树突状细胞、B细胞等)上时，可以与细胞例如T细胞上的同源结合配偶体(本文称为“刺激分子”)特异性结合，从而介导T细胞的初次应答，包括激活、免疫应答的开始、增殖和相似过程。刺激配体在本领域中是众所周知的，并且尤其涵盖载有肽的MHC I类分子、抗CD3抗体、超激动剂抗CD28抗体和超激动剂抗CD2抗体。
术语“治疗的”是指治疗和/或预防。通过抑制、缓解或根除疾病状态或减轻疾病状态的症状可获得治疗效果。
术语“治疗有效量”是指本发明的化合物的量，其将引发研究人员、兽医、医生或另外临床医生所寻求的组织、系统或受试者的生物或医学反应。术语“治疗有效量”包括当施用时足以防止所治疗的病症或疾病的一种或多种病征或症状的发展或在某种程度上对其减轻的化合物的量。治疗有效量将取决于化合物、疾病及其严重程度以及待治疗受试者的年龄、体重等而变化。
术语“治疗疾病”是指降低受试者经历的疾病或病症的至少一种病征或症状的频率或严重程度。
术语“转染的”或“转化的”或“转导的”是指将外源核酸转移或引入宿主细胞中的过程。“转染的”或“转化的”或“转导的”细胞是已用外源核酸转染、转化或转导的细胞。所述细胞包括原代受试者细胞及其后代。
术语“载体”是指包含分离的核酸并且可用于将分离的核酸递送至细胞内部的多核苷酸。在本领域中已知许多载体，包括线性多核苷酸、与离子或两亲化合物缔合的多核苷酸、质粒和病毒。因此，术语“载体”包括自主复制质粒或病毒。所述术语还包括促进核酸转移到细胞中的非质粒和非病毒化合物，诸如例如聚赖氨酸化合物、脂质体等。病毒载体的实例包括腺病毒载体、腺伴随病毒载体、逆转录病毒载体等。例如，慢病毒是复杂的逆转录病毒，其除了常见的逆转录病毒基因gag、pol和env外，还包含具有调节或结构功能的其他基因。慢病毒载体是本领域众所周知的。慢病毒的一些实例包括人免疫缺陷病毒：HIV-1、HIV-2和猿猴免疫缺陷病毒：SIV。慢病毒载体是通过多重减毒HIV毒力基因生成的，例如，使基因env、vif、vpr、vpu和nef缺失，从而使得载体具有生物安全性。
范围：在整个本公开中，可以以范围格式来呈现本公开的各个方面。应当理解，范围格式的描述仅是为了方便和简洁，而不应被解释为对本公开范围的不可改变的限制。因此，对范围的描述应被认为已明确公开了所有可能的子范围以及所述范围内的各个数值。例如，对范围的描述诸如从1到6应被认为已明确公开了子范围，诸如从1到3、从1到4、从1到5、从2到4、从2到6、从3到6等，以及所述范围内的单个数字，例如1、2、2.7、3、4、5、5.3和6。无论范围的宽度如何，这都适用。
“嵌合抗原受体”(CAR)分子是至少包括细胞外结构域、跨膜结构域和细胞质结构域或细胞内结构域的重组多肽。在实施方案中，CAR的结构域在相同多肽链上，例如嵌合融合蛋白。在实施方案中，所述结构域在不同多肽链上，例如结构域是不连续的。
CAR分子的细胞外结构域包括抗原结合结构域。在实施方案中，抗原结合结构域与B细胞表面上的抗原，例如细胞表面分子或标志物结合。在实施方案中，B细胞的细胞表面分子包括CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138或CD13。在实施方案中，B细胞的细胞表面分子是CD19、CD20、CD22或BCMA。在具体实施方案中，B细胞的细胞表面分子是CD19。
在实施方案中，抗原结合结构域与肿瘤表面上的抗原，例如肿瘤抗原或肿瘤标志物结合。肿瘤抗原是由肿瘤细胞产生的引发免疫应答的蛋白质，特别是T细胞介导的免疫应答。肿瘤抗原是本领域众所周知的，并且包括例如肿瘤相关的MUC1、神经胶质瘤相关抗原、癌胚抗原(CEA)、β-人绒毛膜促性腺激素、甲胎蛋白(AFP)、凝集素反应性AFP、甲状腺球蛋白、RAGE-1、MN-CAIX、人端粒酶逆转录酶、RU1、RU2(AS)、肠羧酸酯酶、mut hsp70-2、M-CSF、前列腺酶(prostase)、前列腺特异性抗原(PSA)、PAP、NY-ESO-1、LAGE-1a、p53、前列腺特异性蛋白(prostein)、PSMA、Her2/neu、存活素、端粒酶、前列腺癌肿瘤抗原-1(PCTA-1)、MAGE、ELF2M、中性粒细胞弹性蛋白酶、肝配蛋白B2、CD22、胰岛素生长因子(IGF)-I、IGF-II、IGF-I受体和间皮素。例如，当肿瘤抗原是CD19时，其CAR可被称为CD19 CAR。
在实施方案中，CAR的细胞外抗原结合结构域包括至少一个scFv或至少单域抗体。作为实例，在CAR上可以存在两个scFv。scFv包括通过柔性接头连接的靶抗原特异性单克隆抗体的轻链可变(VL)区和重链可变(VH)区。通过使用短连接肽连接轻链可变区和/或重链可变区可制备单链可变区片段(Bird等人,Science 242:423-426,1988)。连接肽的实例是具有氨基酸序列(GGGGS)3(SEQ ID:278)的GS接头，其在一个可变区的羧基末端和另一可变区的氨基末端之间桥接约3.5nm。已设计并使用了其他序列的接头(Bird等人,1988,同上)。通常，接头可以是短的柔性多肽，并且优选包含约20个或更少的氨基酸残基。单链变体可以重组或合成产生。针对scFv的合成产生，可以使用自动合成仪。针对scFv的重组产生，可以将合适的含有编码scFv的多核苷酸的质粒引入合适的宿主细胞中，所述宿主细胞可以是真核生物，诸如酵母、植物、昆虫或哺乳动物细胞，或者可以是原核生物，诸如大肠杆菌。编码感兴趣的scFv的多核苷酸可以通过常规操作诸如多核苷酸的连接来制备。可以使用本领域已知的标准蛋白质纯化技术分离所得的scFv。
本文描述的CAR分子的细胞质结构域包括一个或多个共刺激结构域和一个或多个信号传导结构域。共刺激结构域和信号传导结构域的功能在于响应于抗原结合传递信号并激活分子，诸如T细胞。一个或多个共刺激结构域衍生自刺激分子和/或共刺激分子，并且信号传导结构域衍生自初级信号传导结构域，诸如CD3ζ结构域。在实施方案中，信号传导结构域还包括一个或多个衍生自共刺激分子的功能性信号传导结构域。在实施方案中，共刺激分子是用于激活针对抗原的细胞应答所必需的细胞表面分子(除抗原受体或其配体以外)。
在实施方案中，共刺激结构域包括以下的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其任何组合。在实施方案中，信号传导结构域包括衍生自T细胞受体的CD3ζ结构域。
在实施方案中，CAR的细胞质结构域仅包括一个或多个刺激结构域并且不包括信号传导结构域。
CAR分子还包括跨膜结构域。将跨膜结构域并入CAR分子使分子稳定。在实施方案中，CAR分子的跨膜结构域是CD28或4-1BB分子的跨膜结构域。
在CAR的细胞外结构域与跨膜结构域之间，可以并入间隔域。如本文所用，术语“间隔域”通常意指起到将跨膜结构域连接至多肽链上的细胞外结构域或细胞质结构域的作用的任何寡肽或多肽。间隔域可以包含高达300个氨基酸，优选地10至100个氨基酸，并且最优选地25至50个氨基酸。
本公开描述了编码至少两种不同抗原结合结构域的分离的核酸。在实施方案中，存在与WBC表面上的抗原结合的第一抗原结合结构域，并且存在与肿瘤上的抗原结合的第二抗原结合结构域，肿瘤上的抗原不同于WBC表面上的抗原。第一抗原结合结构域的功能在于使其被引入的细胞扩增，而第二抗原结合结构域的功能在于与靶抗原结合后，抑制含有靶肿瘤抗原的肿瘤细胞生长或杀死所述肿瘤细胞。在实施方案中，本文描述的分离的核酸编码同一核酸分子上的第一抗原结合结构域和第二抗原结合结构域。在实施方案中，两种抗原结合结构域由两种单独的核酸分子编码。例如，第一核酸编码第一抗原结合结构域，并且第二核酸编码第二抗原结合结构域。
在实施方案中，本公开描述了编码结合分子的第一抗原结合结构域和结合分子的第二抗原结合结构域的核酸，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原。在实施方案中，第二结合结构域不结合B细胞标志物。在实施方案中，第二结合结构域包括scFv，其包含SEQ ID No:264或265的氨基酸序列。例如，第二抗原结合结构域在具有SEQ ID No:271-277的氨基酸序列之一的CAR上。
在实施方案中，第一抗原结合结构域和第二抗原结合结构域可以在两种不同的结合分子(第一结合分子和第二结合分子)上，诸如第一CAR和第二CAR。作为实例，第一CAR包括与B细胞表面上的标志物结合的细胞外结合结构域，并且第二CAR包括与肿瘤细胞的靶抗原结合的细胞外结合结构域。在实施方案中，第一CAR和第二CAR由不同核酸编码。在实施方案中，第一CAR和第二CAR是两种不同的结合分子，但由单种核酸编码。
在实施方案中，两种不同的抗原结合结构域可在相同结合分子上，例如在双特异性CAR上，并由单种核酸编码。在实施方案中，双特异性CAR可具有由接头连接在一起的两种不同scFv分子。
在实施方案中，两种不同的抗原结合结构域可在由单独的核酸编码的CAR和T细胞受体(TCR)上。TCR的结合结构域可靶向肿瘤细胞上的特异性肿瘤抗原或肿瘤标志物。在实施方案中，TCR结合结构域是靶向特异性肿瘤抗原的TCRα结合结构域或TCRβ结合结构域。在实施方案中，TCR包含TCRγ和TCRδ链或TCRα和TCRβ链。
本公开还描述了包含上述分离的核酸的载体。在实施方案中，单个载体包含编码第一CAR和第二CAR或TCR的分离的核酸。在实施方案中，第一载体包含编码第一CAR的第一核酸，第二载体包含编码第二CAR或TCR的核酸。在实施方案中，载体包含双特异性CAR，所述双特异性CAR包括至少两种抗原结合结构域。
此外，本公开描述了包含上述分离的核酸或载体的细胞。将细胞与本文描述的分离的核酸或载体一起引入，并表达至少两种以上的不同结合结构域。在实施方案中，细胞包括第一抗原结合结构域和第二抗原结合结构域，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原。此外，本公开描述了包含本文描述的细胞群的组合物。在实施方案中，细胞是淋巴细胞。在具体实施方案中，淋巴细胞是T细胞、NK细胞或树突状细胞。
本公开还描述了培养上述细胞的方法。本文描述的方法包括获得包含第一抗原结合结构域和第二抗原结合结构域的细胞，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原；以及在衍生自WBC的细胞表面分子或衍生自第二抗原结合结构域结合的抗原的试剂存在下培养细胞。在实施方案中，试剂是WBC的细胞表面分子的细胞外结构域。
本公开描述了用于体外细胞制备的方法，其中方法包括提供细胞；将编码第一抗原结合结构域和第二抗原结合结构域的一种或多种核酸引入细胞中，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原；以及在衍生自WBC的细胞表面分子或衍生自第二抗原结合结构域结合的抗原的试剂存在下培养细胞。
本公开描述了使用制备的细胞制品来增强患有癌症的受试者中的T细胞扩增。在实施方案中，方法包括将多种核酸引入T细胞，多种核酸编码结合实体瘤抗原的嵌合抗原受体(CAR)和编码结合B细胞抗原的CAR，T细胞的至少一部分包含结合实体瘤抗原的CAR和结合B细胞抗原的CAR；以及向受试者施用有效量的T细胞。
另外，本公开描述了用于在受试者中引入和/或增强淋巴细胞(T细胞)应答的方法。本文描述的实施方案涉及扩增淋巴细胞的机制和涉及CAR上的抗原与肿瘤细胞结合的机制。在实施方案中，第一种机制涉及与信号相关的分子，该信号涉及在受试者中扩增淋巴细胞，而另一种机制涉及与信号相关的分子，该信号指示在受试者中结合肿瘤细胞、抑制肿瘤细胞的生长或杀死肿瘤细胞。例如，第一种机制包括与血液(诸如血细胞和血浆)或非必需组织相关的抗原结合的CAR，另一种机制包括靶向与肿瘤细胞相关的抗原的CAR或TCR。非必需组织的实例包括乳腺、结肠、胃腺、卵巢、血液组分(诸如WBC)和甲状腺。在实施方案中，第一种机制涉及分子的第一结合结构域，另一种机制涉及分子的第二结构域。在实施方案中，第一种机制和另一种机制由相同分子或由单独的分子执行。在具体实施方案中，一种机制涉及表达与肿瘤细胞相关的抗原的细胞，而另一种机制涉及具有抗原结合结构域的淋巴细胞。
本文描述的方法涉及包括扩增分子和功能分子的淋巴细胞。在实施方案中，扩增分子扩增受试者中的淋巴细胞，和/或功能分子抑制受试者中的肿瘤细胞的生长或杀死肿瘤细胞。在实施方案中，扩增分子和功能分子在单个CAR分子上，例如双特异性CAR分子。在实施方案中，扩增分子和功能分子在单独的分子上，例如，CAR和TCR或两种不同的CAR。扩增分子可以包括与血液(例如血细胞和血浆)或非必需组织相关的抗原结合的CAR，功能分子可以包括靶向与肿瘤细胞相关的抗原的CAR或TCR。
受试者中的淋巴细胞或T细胞应答是指与辅助、杀伤、调节和其他类型的T细胞相关的细胞介导免疫。例如，T细胞应答可包括诸如在免疫过程中协助其他WBC以及鉴定和破坏病毒感染的细胞和肿瘤细胞的活动。受试者中的T细胞应答可通过各种指标进行测量，诸如T细胞杀死的许多病毒感染细胞和/或肿瘤细胞，体外和/或与病毒感染细胞和/或肿瘤细胞共同培养时T细胞释放的细胞因子(例如，IL-6和IFN-γ)的量、受试者中T细胞的增殖水平、T细胞的表型改变(例如记忆T细胞改变)以及受试者中T细胞的长寿或寿命水平。
在实施方案中，增强T细胞应答的方法可治疗有需要的受试者，例如，诊断有肿瘤的受试者。术语肿瘤是指肿块，其可以是诸如血液的流体聚集体，或者是实体肿块。肿瘤可以是恶性的(癌性的)或良性的。血液癌症的实例包括慢性淋巴细胞性白血病、急性髓细胞性白血病、急性淋巴细胞性白血病和多发性骨髓瘤。
实体瘤通常不包含囊肿或液体区域。恶性实体瘤的主要类型包括肉瘤和癌瘤。肉瘤是在称为间质细胞的软组织细胞中发展的肿瘤，其可以存在于血管、骨骼、脂肪组织、韧带淋巴管、神经、软骨、肌肉、韧带或肌腱中，而癌瘤是在上皮细胞中形成的肿瘤，其存在于皮肤和粘膜中。最常见的肉瘤类型包括涉及软组织和骨细胞的未分化多形性肉瘤；涉及遍布血管、胃肠道和子宫的平滑肌细胞的平滑肌肉瘤；涉及骨细胞的骨肉瘤以及涉及脂肪细胞的脂肪肉瘤。肉瘤的一些实例包括尤文氏肉瘤、横纹肌肉瘤、软骨肉瘤、间皮瘤、纤维肉瘤和神经胶质瘤。
四种最常见的癌瘤包括涉及产生流体或粘液的器官(诸如乳房和前列腺)的肾上腺癌；涉及皮肤最外层细胞的基底细胞癌，例如皮肤癌；涉及皮肤基底细胞的鳞状细胞癌；以及影响泌尿道中的移行细胞的移行细胞癌，所述泌尿道包括膀胱、肾脏和输尿管。癌瘤的实例包括甲状腺癌、乳癌、前列腺癌、肺癌、肠癌、皮肤癌、胰腺癌、肝癌、肾癌和膀胱癌以及胆管癌。
本文描述的方法可用于治疗诊断有癌症的受试者。癌症可以是血癌或可以是实体瘤，诸如肉瘤或癌瘤。治疗方法包括向受试者施用有效量的T细胞以提供T细胞应答，所述T细胞包含第一抗原结合结构域和第二抗原结合结构域，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原。在实施方案中，增强受试者中的T细胞应答包括在体内选择性增强表达第一抗原结合结构域和第二抗原结合结构域的T细胞的增殖。
在实施方案中，向受试者施用的用于增强受试者中T细胞应答的T细胞包括包含双特异性CAR的T细胞，所述双特异性CAR包括两种不同的结合结构域；或施用包含第一CAR和第二CAR的T细胞，其中第一CAR和第二CAR各自包括不同的抗原结合结构域。
在实施方案中，用于增强受试者中T细胞应答的方法包括施用包含CAR分子和TCR分子的T细胞。CAR分子靶向或结合白细胞的表面标志物，并且TCR分子结合在肿瘤细胞表面或内部表达的肿瘤标志物或抗原。
本公开描述了在体内扩增表达抗原结合结构域的细胞的方法。方法包括向有需要的受试者施用有效量的T细胞，所述T细胞包含第一抗原结合结构域和第二抗原结合结构域，其中第一抗原结合结构域结合WBC的细胞表面分子，并且第二抗原结合结构域结合不同于WBC的细胞表面分子的抗原。方法可用于扩增T细胞、NK细胞或树突状细胞。
在实施方案中，第一抗原结合结构域在第一嵌合抗原受体(CAR)上，并且第二抗原结合结构域在第二CAR或TCR上。例如，第一CAR和第二CAR或TCR包括细胞外抗原结合结构域、跨膜结构域和细胞质结构域。第一CAR的细胞质结构域包括用于传递信号以激活细胞应答的共刺激结构域和CD3ζ结构域。在实施方案中，第一CAR的细胞质结构域包括一个或多个共刺激结构域且不存在CD3ζ结构域，使得激活或刺激第一CAR扩增WBC(诸如淋巴细胞)，而不会引入和/或激活WBC的杀伤功能。在实施方案中，淋巴细胞是T细胞。
在实施方案中，第一抗原结合结构域和第二抗原结合结构域在相同CAR(第一CAR)上，例如具有细胞外抗原结合结构域、跨膜结构域和细胞质结构域的双特异性CAR。细胞外抗原结合结构域包括至少两个scFv，并且scFv中的至少一个用作第一抗原结合结构域，以用于结合WBC的细胞表面分子。
在实施方案中，不同于WBC的细胞表面分子的抗原是CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138、CD13、B7、CAIX、CD123、CD133、CD171、CD171/L1-CAM、CEA、Claudin 18.2、cMet、CS1、CSPG4、Dectin1、EGFR、EGFR vIII、EphA2、ERBB受体、ErbBT4、ERBB2、FAP、叶酸受体1、FITC、FSH、GD2、GPC3、HA-1H/HLA-A2、HER2、IL-11Ra、IL13受体a2、IL13R、IL13Rα2(zetakine)、Kappa、LewisY、间皮素、MUC1、NKG2D、NY-ESO-1、PSMA、ROR-1、TRAIL受体1或VEGFR2。
在实施方案中，MUC1是人MUC1的肿瘤排他性表位，并且第一CAR和第二CAR或TCR被表达为单独的多肽。在实施方案中，MUC1是人MUC1的肿瘤形式(tMUC1)。
在实施方案中，第一CAR包括共刺激结构域且不具有信号传导结构域，诸如CD3ζ结构域，而MUC1 CAR(第二CAR)包含MUC1结合结构域、跨膜结构域、共刺激和CD3ζ结构域。
如本文所用，术语“MUC1”是指如下所定义的分子。MUC1是上皮粘蛋白家族分子之一。MUC1是通常在主要器官的所有腺上皮细胞上表达的跨膜粘蛋白糖蛋白。在正常细胞中，MUC1仅在腔面上表达，并被其由碳水化合物隔离的核心蛋白高度糖基化。随着细胞转化为恶性表型，MUC1的表达增加数倍，并且表达不再局限于腔面，而是遍布细胞表面和细胞质中。另外，与肿瘤相关的MUC1的糖基化异常，其中肽核的暴露量比正常组织中表达的MUC1中存在的量更大。关于异常糖基化的细节知之甚少。
MUC1广泛表达在许多上皮癌中，并且异常糖基化使其在结构和抗原上相异于非恶性细胞表达的MUC1(参见，例如Barratt-Boyes,1996；Price等人,1998；Peterson等人,1991)。MUC1的主要形式是一种高分子量分子，其包含具有大量的二十个氨基酸串联重复单元的高度免疫原性细胞外粘蛋白样结构域、跨膜区和胞质尾区(Quin等人,2000；McGucken等人,1995；Dong等人,1997)。
在包括乳房和胰腺在内的大多数上皮腺癌中，MUC1过表达且糖基化异常。乳房和胰腺的腺癌不仅过表达MUC1，而且使MUC1进入循环。高MUC1血清水平与进行性疾病相关。由于抗原内表达的表位具有复杂性和异质性，因此MUC1被用作前瞻性生物标志物。由癌性组织合成的MUC1(例如，肿瘤相关的MUC1)通常表现出异常的低聚糖特性(profile)，这会引起新标志物(neomarker)诸如唾液酸化-Lea(在CA19-9测试中测定)、唾液酸化-Lex和唾液酸化-Tn(TAG-72)，以及隐性表位诸如Tn的表达。
正在开发针对MUC1的几种抗体以用于治疗。培妥木单抗(Pemtumomab)(又称为HMFG1)作为将放射性同位素钇-90递送到卵巢癌肿瘤中的载体，正处于III期临床试验中(Scott等人对其进行了综述,2012)。CA15-3(又称为HMFG1抗体)、CA27-29和CA19-9均是MUC1的抗体，其用于评定患有癌症的患者中循环MUC1的水平。然而，这些抗体作为治疗剂或作为生物标志物的作用有限，因为它们不能有效地区分正常的上皮细胞与转化的肿瘤上皮细胞上表达的MUC1。换句话说，这些抗体似乎都没有靶向肿瘤特异性MUC1表位。
对肿瘤特异性形式的MUC1(tMUC)具有高度特异性的新抗体被称为TAB-004并描述在美国专利号8,518,405中(另参见Curry等人,2013)。虽然使用人乳脂肪球将培妥木单抗(HMFG1)开发为抗原(Parham等人,1988)，但使用表达MUC1的改变形式的肿瘤开发了TAB-004(Tinder等人,2008)。TAB-004可识别MUC1串联重复序列内改变的糖基化表位。该区域可用于tMUC中的抗原检测，但由于糖基化的大分支而无法在正常MUC1中进行抗原检测(Gendler,2001；Mukherjee等人,2003b；Hollingsworth&Swanson,2004；Kufe,2009)。重要地，TAB-004不同于其他MUC1抗体识别的表位，并且具有重链和轻链的独特互补决定区(CDR)。该抗体以3ng/ml(20pM)的高结合亲和力与靶抗原结合，并且不与无关的抗原结合(Curry等人,2013)。因此，TAB-004可区分MUC1的正常形式与肿瘤形式，而HMFG1(培妥木单抗)不能(参见美国专利号8,518,405)。
在实施方案中，WBC是粒细胞、单核细胞和/或淋巴细胞。在实施方案中，WBC是B细胞。
在实施方案中，第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域，和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
在实施方案中，抗原结合结构域是Fab或scFv。在实施方案中，第一CAR包含SEQ IDNO:5、6和53-58之一的氨基酸序列；并且第二CAR包含SEQ ID NO:5-17、29、33、37、71和72之一的氨基酸序列或由SEQ ID NO:41、45、63、67和68之一的核酸序列编码的氨基酸序列。在实施方案中，编码第一CAR的核酸序列包含SEQ ID NO:59或60的核酸序列，并且编码第二CAR的核酸序列包含SEQ ID NO:61的核酸序列。在实施方案中，分离的核酸包含SEQ ID NO:62-69的核酸序列之一。在实施方案中，第一CAR和第二CAR表达为单独的多肽。
在实施方案中，第一抗原结合结构域在CAR上，并且第二抗原结合结构域在T细胞受体(TCR)上。在实施方案中，TCR是修饰的TCR。在实施方案中，TCR衍生自患者中自发产生的肿瘤特异性T细胞。在实施方案中，TCR与肿瘤抗原结合。在实施方案中，肿瘤抗原包括CEA、gp100、MART-1、p53、MAGE-A3或NY-ESO-1。
在实施方案中，可分离表达对靶抗原具有高亲和力的TCR的T细胞克隆物。可以在多肽负载的抗原呈递细胞(APC)存在下培养肿瘤浸润淋巴细胞(TIL)或外周血单核细胞(PBMC)，所述多肽代表当存在于特定的HLA等位基因背景下时已知的可用于引起显性T细胞应答的表位；然后可基于MHC-肽四聚体染色和/或识别和裂解用低滴定浓度的同源肽抗原负载的靶细胞的能力来选择高亲和力克隆物。在选择克隆物后，通过分子克隆鉴定和分离TCRα和TCRβ链或TCRγ和TCRδ链。例如，对于TCRα和TCRβ链，然后使用TCRα和TCRβ基因序列来生成表达构建体，所述表达构建体可理想地促进人T细胞中两条TCR链的稳定、高水平表达。然后可生成转导媒介物(例如γ逆转录病毒或慢病毒)并测试其功能性(抗原特异性和功能亲和力)，并且用于产生大量的临床载体。然后可以使用等分试样的最终产品转导靶T细胞群(通常从患者PBMC中纯化)，所述靶T细胞群在输注到患者之前进行扩增。
可实施各种方法来获得编码肿瘤反应性TCR的基因。更多信息提供在Kershaw等人,Clin Transl Immunology.2014年5月；3(5):e16中。在实施方案中，特异性TCR可衍生自患者中自发产生的肿瘤特异性T细胞。此类别中包括的抗原包括黑色素细胞分化抗原MART-1和gp100，以及MAGE抗原和NY-ESO-1，它们在更广泛的癌症中表达。只要病毒蛋白由转化细胞表达，对病毒相关的恶性肿瘤具有特异性的TCR也可以被分离。此类别中的恶性肿瘤包括与肝炎和乳头瘤病毒相关的肝癌和宫颈癌，以及与爱泼斯坦-巴尔病毒相关的恶性肿瘤。在实施方案中，TCR的靶抗原可包括CEA(例如，针对结肠直肠癌)、gp100、MART-1、p53(例如，针对黑色素瘤)、MAGE-A3(例如，黑色素瘤、食管肉瘤和滑膜肉瘤)、NY-ESO-1(例如，针对黑色素瘤和肉瘤以及多发性骨髓瘤)。
在实施方案中，第一CAR的结合结构域与CD19结合，并且第二CAR的结合结构域与肿瘤相关的MUC1结合。在实施方案中，第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:76或85的氨基酸序列；重链互补决定区2，其包含SEQ ID:77或86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78或87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73或82的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)或SEQID:83的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75或84的氨基酸序列。
在实施方案中，第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:76的氨基酸序列；重链互补决定区2，其包含SEQ ID:77的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75的氨基酸序列。
在实施方案中，第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:85的氨基酸序列；重链互补决定区2，其包含SEQ ID:86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:82的氨基酸序列；轻链互补决定区2，其包含SEQ ID:83的氨基酸序列；和轻链互补决定区3，其包含SEQID:84的氨基酸序列。在实施方案中，第一CAR的结合结构域包含SEQ ID:5或6的氨基酸序列。在实施方案中，第二CAR的结合结构域包含SEQ ID:70-72和79-81的氨基酸序列之一。
在实施方案中，第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域，和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
在实施方案中，第一CAR和第二CAR表达为单独的多肽。
在实施方案中，第二CAR的细胞质结构域或跨膜结构域被修饰以使得第二CAR能够通过表达CD19的细胞激活修饰的T细胞，而不会损害表达CD19的细胞。
本文描述的实施方案涉及一种双特异性嵌合抗原受体，其包含：第一抗原结合结构域、第二抗原结合结构域、细胞质结构域和跨膜结构域，其中第一抗原结合结构域识别第一抗原，并且第二抗原结合结构域识别第二抗原，第一抗原不同于第二抗原。
在实施方案中，第一抗原和第二抗原不在相同细胞上表达。在实施方案中，第一抗原是血液组分的抗原，并且第二抗原是实体瘤的抗原。
血细胞是指红细胞(RBC)、白细胞(WBC)、血小板或其他血细胞。例如，RBC是通过血流流经循环系统而将氧气(O2)递送至身体组织的血细胞。血小板是涉及止血的细胞，从而致使血块形成。WBC是涉及防御身体免受传染性疾病和异物侵害的免疫系统的细胞。存在许多不同类型和子类型的WBC，每种都有不同的作用。例如，粒细胞、单核细胞和淋巴细胞是白细胞的3种主要类型。存在三种不同形式的粒细胞：中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞。
WBC的细胞表面分子是指在WBC表面上表达的分子。例如，淋巴细胞的细胞表面分子可包括CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56和CD30。B细胞的细胞表面分子可包括CD19、CD20、CD22、BCMA。单核细胞的细胞表面分子可包括CD14、CD68、CD11b、CD18、CD169和CD1c。粒细胞的细胞表面分子可包括CD33、CD38、CD138和CD13。
在实施方案中，第一抗原是CD19，并且第二抗原是肿瘤相关的MUC1。在实施方案中，第一抗原结合结构域包含SEQ ID:5和6的氨基酸序列之一。在实施方案中，第二抗原结合结构域包含SEQ ID:70-72和79-81的氨基酸序列之一。
在实施方案中，本公开描述了一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，方法包括：向受试者施用有效量的修饰的T细胞以提供T细胞应答，使得CAR T细胞通过表达CD19的细胞在受试者血液中扩增。在实施方案中，方法可还包括将B细胞输注到受试者中以继续激活和/或扩增CAR T细胞。例如，可在CAR T细胞输注之前获得并储存受试者的B细胞或来自健康供体的基因修饰B细胞。在实施方案中，方法可还包括施用表达CD19的细胞或至少包含CD19的细胞外结构域的多肽或CAR T细胞识别的抗原。例如，表达CD19的细胞可包括用编码CD19的核酸序列转导的细胞系，诸如K562和NK92。在实施方案中，方法可还包括识别同时表达第一CAR和第二CAR的CAR T细胞，以及向受试者施用标识物CAR T细胞。例如，MUC1可以与分选标志物相关，使得可及时识别表达MUC1的CAR T细胞。
在实施方案中，肿瘤相关的MUC1表达在肿瘤细胞上，但不表达在相应非恶性细胞上。在实施方案中，针对肿瘤相关的MUC1的scFv直接与邻糖基化的GSTA基序(SEQ IDNO.88)相互作用。
本文描述的实施方案涉及一种包含双特异性CAR的细胞，并且涉及一种编码双特异性CAR的分离的核酸。
在实施方案中，本公开描述了一种体内细胞扩增的方法。在实施方案中，方法可包括向受试者施用有效量的包含CAR的T细胞，以提供T细胞应答；以及施用有效量的表达可溶性试剂的呈递细胞(例如，T细胞)，所述可溶性试剂为CAR的细胞外结构域可识别的。在实施方案中，方法可实施以增强受试者中的T细胞应答。方法可包括向受试者施用有效量的包含CAR的T细胞以提供T细胞应答，以及施用有效量的表达可溶性试剂的呈递细胞以增强受试者中的T细胞应答，所述可溶性试剂为CAR的细胞外结构域可识别的。在某些实施方案中，呈递细胞是T细胞、树突状细胞和/或抗原呈递细胞。在某些实施方案中，增强受试者中的T细胞应答包括选择性增强包含CAR的T细胞的增殖。在实施方案中，方法可用于使用CAR T细胞增强对受试者病状的治疗。方法可包括施用表达试剂的细胞群或施用被配制成疫苗的试剂。在这些情况下，CAR T细胞包含编码CAR的核酸，并且CAR的细胞外结构域识别所述试剂。在实施方案中，方法可实施以在患有疾病的受试者中增强CAR T细胞的增殖。方法可包括制备包含CAR的CAR T细胞；向受试者施用有效量的CAR T细胞；将编码试剂的核酸引入细胞中，所述试剂是CAR的细胞外结构域可识别的；以及向受试者施用有效量的细胞(用编码所述试剂的核酸引入)。在实施方案中，可基于T细胞基因组DNA中CAR分子拷贝数的增加来测量T细胞扩增。在实施方案中，可基于对T细胞上表达的分子进行的流式细胞分析来测量T细胞扩增。
本文描述的实施方案涉及一种包含第一CAR和第二CAR的分离的T细胞，其中第一CAR的抗原结合结构域与抗原诸如CD19、CD33、CD14和BCMA结合，并且第二CAR的抗原结合结构域与肿瘤相关的MUC结合。在实施方案中，肿瘤相关的MUC是MUC1或MUC2。本文描述的实施方案涉及一种包含分离的T细胞群的组合物，并且涉及一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，方法包括：施用有效量的分离的T细胞。
在实施方案中，第一CAR包含SEQ ID NO:207的氨基酸序列，并且第二CAR包含SEQID:202的氨基酸序列。在实施方案中，第一CAR包含SEQ ID NO:203、207、216或219的氨基酸序列，并且第二CAR包含SEQ ID:202或205的氨基酸序列。在实施方案中，第二CAR的抗原结合结构域包含SEQ ID NO:70的氨基酸序列。在实施方案中，第二CAR的抗原结合结构域包含SEQ ID NO:5或6的氨基酸序列。在实施方案中，分离的T细胞包含SEQ ID NO:201、204、206、208、215、217、218或220的核酸序列。在实施方案中，第一CAR和第二CAR各自包含抗原结合结构域、跨膜结构域和细胞质结构域。
在实施方案中，细胞质结构域包含共刺激结构域和CD3ζ结构域。
在实施方案中，分离的T细胞包含以下受体的显性失活变体：程序性死亡1(PD-1)、细胞毒性T淋巴细胞抗原-4(CTLA-4)、B淋巴细胞和T淋巴细胞弱化因子(BTLA)、T细胞免疫球蛋白粘蛋白-3(TIM-3)、淋巴细胞激活蛋白3(LAG-3)、具有Ig和ITIM结构域的T细胞免疫受体(TIGIT)、白细胞相关的免疫球蛋白样受体1(LAIR1)、自然杀伤细胞受体2B4(2B4)或CD160。在实施方案中，与相应的野生型T细胞相比，分离的T细胞包含减少量的TCR。显性失活突变具有改变的基因产物，所述基因产物对野生型等位基因起拮抗作用。这些突变通常导致分子功能改变(通常是无活性的)，并且特征在于显性或半显性表型。
本公开描述了药物组合物。药物组合物包含以下的一种或多种：上述的CAR分子、TCR分子、修饰的CAR T细胞、包含CAR或TCR的修饰的细胞、修饰的细胞、核酸以及载体。药物组合物以适合于待治疗(或预防)的疾病的方式施用。尽管可以通过临床试验确定适当的剂量，但是施用的数量和频率将由诸如患者的病状以及患者疾病的类型和严重程度等因素来确定。
当指示“免疫学有效量”、“抗肿瘤有效量”、“肿瘤抑制有效量”或“治疗量”时，可以由医生考虑年龄、体重、肿瘤大小、感染或转移的程度以及患者(受试者)的病状的个体差异确定待施用的本公开的组合物的精确量。可以这样说，包含本文描述的T细胞的药物组合物可以104至109个细胞/千克体重的剂量施用，优选地105至106个细胞/千克体重的剂量，包括这些范围内的所有整数值。T细胞组合物也可以这些剂量施用多次。可以通过使用免疫疗法中通常已知的输注技术来施用细胞(参见，例如Rosenberg等人,New Eng.J.of Med.319:1676,1988)。通过监测患者的疾病病征并相应地调整治疗，医学领域的技术人员可以容易地确定针对特定患者的最佳剂量和治疗方案。在某些实施方案中，可需要向受试者施用激活的T细胞，然后再抽血(或进行单采)，收集激活的和扩增的T细胞，并向患者再注入这些激活的和扩增的T细胞。此过程可以每几周进行多次。在某些实施方案中，可以从10cc至400cc的抽血中激活T细胞。在某些实施方案中，从20cc、30cc、40cc、50cc、60cc、70cc、80cc、90cc或100cc的抽血中激活T细胞。不受理论的束缚，使用这种多次抽血/多次再输注的方案可以选择出某些T细胞群。
本文描述的药物组合物的施用可以任何方便的方式进行，包括通过雾化吸入、注射、摄取、输注、植入或移植。本文描述的组合物可以皮下、皮内、肿瘤内、结节内、髓内、肌内、通过静脉内(i.v.)注射或或腹膜内向患者施用。在实施方案中，本文描述的T细胞组合物通过皮内或皮下注射向受试者施用。在实施方案中，本公开的T细胞组合物通过静脉内注射来施用。T细胞的组合物可以直接注射到肿瘤、淋巴结或感染部位。在实施方案中，结合任何数量的相关治疗方法(例如，在之前、同时或之后)向患者施用细胞，所述细胞通过使用本文描述的方法或本领域已知的其他方法进行激活和扩增，其中T细胞被扩增至治疗水平，所述任何数量的相关治疗方法包括但不限于针对抗病毒疗法使用试剂的治疗；针对MS患者的西多福韦和白介素-2、阿糖孢苷(也称为ARA-C)或那他珠单抗治疗；或针对牛皮癣患者的依法珠单抗治疗或针对PML患者的其他治疗。在进一步的实施方案中，本文描述的T细胞可与以下组合使用：化学疗法、放射、免疫抑制剂(诸如环孢菌素、硫唑嘌呤、甲氨蝶呤、霉酚酸酯和FK506)、抗体或其他免疫消除剂(诸如CAM PATH)、抗CD3抗体或其他抗体疗法、细胞毒素、氟达立滨、环孢菌素、FK506、雷帕霉素、霉酚酸、类固醇、FR901228、细胞因子和辐照。这些药物抑制钙依赖性磷酸酶钙调磷酸酶(环孢素和FK506)或抑制对生长因子诱导的信号传导很重要的p70S6激酶(雷帕霉素)。(Liu等人,Cell 66:807-815,1991；Henderson等人,Immun73:316-321,1991；Bierer等人,Curr.Opin.Immun 5:763-773,1993；Isoniemi(同上))。在实施方案中，将本文描述的细胞组合物与骨髓移植、T细胞消融疗法(使用诸如氟达拉滨的化学治疗剂)、外部束放射疗法(XRT)、环磷酰胺或抗体(诸如OKT3或CAMPATH)结合(例如在之前、同时或之后)向受试者施用。在实施方案中，在B细胞消融疗法之后施用本文描述的细胞组合物。例如，可向患者施用与CD20反应的试剂，例如利妥昔单抗(Rituxan)。在实施方案中，受试者可以经历高剂量化学疗法的标准治疗，接着进行外周血干细胞移植。在某些实施方案中，在移植之后，受试者接受输注本公开的扩增的免疫细胞。在实施方案中，在手术之前或之后施用扩增的细胞。
待向有需要的受试者施用的上述治疗的剂量将随所治疗病状的确切性质和治疗接受者而变化。可以根据各种因素，由医师根据本领域公认的实践来进行用于人类施用的剂量缩放比例。
美国专利号US8,906,682提供了关于使用工程化或修饰的T细胞进行癌症治疗的方法的另外信息，所述美国专利以引用的方式整体并入。
本文描述的实施方案涉及一种用于体外制备修饰的细胞的方法。方法可以包括从受试者中获得细胞样品。例如，样品可以包括T细胞或T细胞祖细胞。方法可还包括用编码至少一种CAR的DNA转染细胞样品，以及在选择性增强表达CAR的T细胞增殖的培养基中离体培养CAR细胞群。
在实施方案中，样品是冷冻保存的样品。在实施方案中，细胞样品来自脐带血，或细胞样品是来自受试者的外周血样品。在实施方案中，细胞样品通过单采或静脉穿刺获得。在实施方案中，细胞样品是T细胞亚群。
本公开的实施方案涉及一种锌指核酸酶(ZFN)，其包含含有锌指DNA结合蛋白的DNA结合结构域和含有切割结构域和/或切割半结构域的DNA切割结构域。
锌指DNA结合蛋白可包含1、2、3、4、5、6或更多个锌指，每个锌指均具有与靶基因中的靶亚位点结合的识别螺旋。在某些实施方案中，锌指蛋白包含3或4或5或6个指状物(其中指状物被命名为F1、F2、F3、F4、F5和F6，并且从N末端至C末端顺序排列为F1至F3、F4或F5或F6)，并且指状物包含表6所示的识别区的氨基酸序列。
切割结构域和/或切割半结构域的实例包括野生型或工程化的FokI切割半结构域。在实施方案中，DNA切割结构域可包括野生型切割结构域或切割半结构域(例如，FokI切割半结构域)。在实施方案中，切割结构域和/或切割半结构域包括工程化的(非天然存在的)切割结构域或切割半结构域，例如，形成专性异二聚体的工程化FokI切割半结构域。
在实施方案中，基因是人类基因。在实施方案中，切割结构域包括野生型或工程化的FokI切割结构域。
实施方案涉及一种编码上述分离的ZFN的多核苷酸。实施方案涉及一种包含多核苷酸的载体。在实施方案中，载体是腺病毒或慢病毒载体。实施方案涉及一种分离的细胞或细胞系，其包含上述的分离的ZFN。
在实施方案中，分离的细胞是干细胞、T细胞或自然杀伤(NK)细胞。在实施方案中，细胞是一种T细胞，所述T细胞衍生自从人类供体分离的原代人T细胞。在实施方案中，细胞对以下的内源基因的表达减少：CTLA4、LAG3、BTLA、TIM3、FOXP3、SIVA1和LGALS9。
CTLA4是用作T细胞应答的主要负调节因子的抑制性受体。T淋巴细胞受体CTLA-4以比共刺激性受体CD28更高的亲和力与共刺激分子CD80(B7-1)和CD86(B7-2)结合，并且负调节T细胞激活。LAG3是免疫球蛋白超家族的成员，并且在激活的T细胞和NK细胞的表面上表达。也在B细胞、树突状细胞、TIL和Treg的表面上检测到LAG3。阻断LAG3可显著增加T细胞增殖和功能。TIM3是由CD4+T辅助细胞1(Th1)、CD8+T细胞毒性1细胞(Tc1)和Th17细胞组成性表达的免疫检查点受体。TIM3与其配体半乳凝集素-9LGALS9之间的相互作用被认为可导致T细胞应答的抑制。FOXP3是转录调节因子的叉头状/有翼状螺旋家族的成员，其对调节性T细胞(Treg)的发育和抑制功能至关重要。SIVA1诱导CD27介导的细胞凋亡，抑制BCL2L1亚型Bcl-x(L)抗凋亡活性，抑制NF-κB的激活，并且促进T细胞受体介导的细胞凋亡。
实施方案涉及一种分离的细胞，其包含编码嵌合抗原受体(CAR)的分离的核酸序列，其中使用上述ZFN使内源基因失活。
在实施方案中，CAR包含抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ信号传导结构域。
在实施方案中，与原代人T细胞的移植物抗宿主疾病(GVHD)应答相比，所述细胞在生物不相容的人受体中的GVHD应答降低。
在实施方案中，CAR的抗原结合结构域与FZD10、TSHR、PRLR、Muc17、GUCY2C、CD207、CD19或CD20结合。
在实施方案中，CAR的抗原结合结构域与以下之一结合：B7、BCMA、CAIX、CD123、CD133、CD138、CD171、CD171/L1-CAM、CD19、CD2、CD22、CD30、CD33、CEA、cMet、CS1、CSPG4、Dectin1、EGFR、EGFR vIII、EphA2、ERBB受体、ErbB T4、ERBB2、FAP、叶酸受体1、FITC、GD2、GPC3、HA-1H/HLA-A2、HER2、IL-11Ra、IL13受体a2、IL13R、IL13Rα2(zetakine)、Kappa、LewisY、间皮素、MUC1、NKG2D、NY-ESO-1、PSMA、ROR-1、TRAIL-受体1或VEGFR2。
在实施方案中，CAR的共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
在实施方案中，分离的细胞或细胞系是包含编码hTERT的核酸序列、或编码SV40LT的核酸或其组合的T细胞。在实施方案中，T细胞包含编码hTERT的核酸序列和编码SV40LT的核酸。在实施方案中，hTERT的表达由诱导型表达系统调节。在实施方案中，SV40LT基因的表达由诱导型表达系统调节。在实施方案中，诱导型表达系统是rTTA-TRE，其增加或激活SV40LT基因或hTERT基因或其组合的表达。在实施方案中，T细胞包含编码自杀基因的核酸序列。在实施方案中，自杀基因包括HSV-TK自杀基因系统。
实施方案涉及一种治疗受试者中的癌症的方法，方法包括向受试者施用基因修饰的细胞，其中癌症选自：肺癌、胰腺癌、肝癌、骨癌、乳癌、结肠直肠癌、白血病、卵巢癌、淋巴瘤和脑癌。
实施方案涉及一种T/NK细胞，所述T/NK细胞与相应的野生型细胞相比包含减少的量的一种或多种肽，所述一种或多种肽包括PD1、PDL1、PDL2、CTLA4、LRBA、LAG3、Tim3、BILA、CD160、2B4、SOCS1、SOCS3、Foxp3、CCR4、PVRIG、CD16B、SIVA1、CD33、LAGLS9、CD122、IDO1、CD45、Cvp1b1、TNFAIP8L2、ID02、TD02、DNMT3A和/或癌胚抗原细胞粘附分子-1(Ceacam-1)。在实施方案中，将T细胞施用到受试者时，T/NK细胞具有增强的T/NK细胞应答。
实施方案涉及T/NK细胞，所述T/NK细胞与相应的野生型细胞相比包含增加的量的一种或多种肽，所述一种或多种肽包括Runx3、lexm、PILRA、Ptnns1L3、Fcgr3a、Nat8、Ccl9、Hck、Trem2、Ccl6、Cd36、Igf1、Ctss、Gzmc、Batf、Cxcl2、TNFAIP8L3、Il1b、TRPV1、TRPV2、TRPV3、TRPV4、Rgs1、PLSCR1、ITGB2、C3AR1、ITGA3、ITGA5、ITGAL、batf、batf3、Cxcl2、CARD11和/或CD83。在实施方案中，将T/NK细胞施用到受试者时，T/NK细胞具有增强的T细胞应答。
在实施方案中，各种基因编辑技术或过表达技术(例如，Cas9、TALEN和ZFN)可用于通过敲除/敲低/过表达/插入一个或多个基因来调节T/NK细胞功能。例如，与相应的野生型细胞相比，修饰的细胞具有减少或增加的PD1、PDL1、PDL2、CTLA4、LRBA、LAG3、Tim3、BILA、CD160、2B4、SOCS1、SOCS3、Foxp3、CCR4、PVRIG、CD16B、SIVA1、CD33、LAGLS9、CD122、IDO1、CD45、Cvp1b1、TNFAIP8L2、ID02、TD02、DNMT3A和/或癌胚抗原细胞粘附分子-1(Ceacam-1)；和Runx3、lexm、PILRA、Ptnns1L3、Fcgr3a、Nat8、Ccl9、Hck、Trem2、Ccl6、Cd36、Igf1、Ctss、Gzmc、Batf、Cxcl2、TNFAIP8L3、Il1b、TRPV1、TRPV2、TRPV3、TRPV4、Rgs1、PLSCR1、ITGB2、C3AR1、ITGA3、ITGA5、ITGAL、batf、batf3、Cxcl2、CARD11和/或CD83列表1和列表2(参见上文)中的肽的生物合成或运输途径的一种或多种基因的表达。
在实施方案中，靶基因是Runx3。例如，与相应的野生型细胞相比，修饰的T/NK细胞具有增加的Runx3表达。在这些情况下，增加的Runx3表达可有助于例如T细胞在肿瘤细胞内浸润或长期驻留，因此增加了T细胞的杀伤作用。
例如，受试者中的T细胞应答是指与辅助、杀伤、调节和其他类型的T细胞相关的细胞介导免疫。例如，T细胞应答可以包括诸如在免疫过程中协助其他白细胞以及鉴定和破坏病毒感染的细胞和肿瘤细胞的活动。受试者中的T细胞应答可通过各种指标进行测量，诸如T细胞杀伤的许多病毒感染细胞和/或肿瘤细胞，与病毒感染细胞和/或肿瘤细胞共同培养时T细胞释放的细胞因子的量、受试者中T细胞的增殖水平、T细胞的表型改变(例如记忆T细胞改变)以及受试者中T细胞的长寿或寿命水平。
T细胞应答还包括细胞因子释放。虽然细胞因子释放通常与全身性炎症和疾病并发症相关，但细胞因子释放似乎也与CAR T细胞疗法的疗效相关。细胞因子释放可与诸如CAR T细胞疗法中，过继转移的细胞的扩增和进行性免疫激活相关。本公开描述了响应于CAR T细胞疗法，尤其是响应于第一CAR和第二CAR的存在而进行的效应细胞因子(诸如IFN-γ)和促炎性与抗炎性细胞因子(诸如IL-6)的释放。在实施方案中，本公开描述了在引入本文描述的第一CAR和第二CAR的受试者中的IL-6和IFN-γ释放。在实施方案中，受试者是有癌症治疗需要的，并且癌症治疗是胰腺癌治疗。在实施方案中，本公开描述了通过测量细胞因子释放的水平来确定CAR T细胞疗法的疗效或监测其疗效。在实施方案中，响应于使用包含第一CAR和第二CAR的T细胞的CAR T细胞疗法在受试者中进行的细胞因子(例如，IL-6和/或IFN-γ)释放程度大于使用包含第二CAR而不包含第一CAR的T细胞的情况。
通过参考以下示例性实施方案和实施例进一步描述本公开。提供这些示例性实施方案和实施例仅出于说明的目的，除非另有说明，否则它们不意图构成限制。因此，本公开决不应解释为限于以下示例性实施方案和实施例，而应解释为涵盖由于本文提供的教导而变得显而易见的任何和所有变型。
示例性实施方案
以下是示例性实施方案：
1.一种编码第一嵌合抗原受体(CAR)和第二CAR的核酸，其中第一CAR的结合结构域结合白细胞(WBC)的细胞表面分子，并且第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原。
2.一种载体，其包含根据实施方案1所述的核酸。
3.一种细胞，其包含根据实施方案1所述的核酸。
4.一种包含第一CAR和第二CAR的细胞，其中第一CAR的结合结构域结合WBC的细胞表面分子，并且第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原。
5.根据实施方案1-4中任一项所述的细胞，其中细胞是T细胞、NK细胞或树突状细胞。
6.一种组合物，其包含根据实施方案3-5中任一项所述的细胞群。
7.一种培养根据实施方案3-5中任一项所述的细胞的方法，所述方法包括：
获得根据实施方案3-5中任一项所述的细胞，其中第一CAR的结合结构域结合WBC的细胞表面分子，并且第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原；以及
在试剂的存在下培养细胞，所述试剂衍生自WBC细胞的细胞表面分子或衍生自第二CAR结合的抗原。
8.根据实施方案7所述的方法，其中试剂是WBC的细胞表面分子的细胞外结构域。
9.一种用于体外CAR细胞制备的方法，所述方法包括：
提供细胞；
将编码第一CAR和第二CAR的核酸引入细胞中，其中第一CAR的结合结构域结合WBC的细胞表面分子，并且第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原；以及
在试剂的存在下培养细胞，所述试剂衍生自WBC的细胞表面分子或衍生自第二CAR结合的抗原。
10.一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，所述方法包括：向受试者施用有效量的包含第一CAR和第二CAR的T细胞以提供T细胞应答，其中第一CAR的结合结构域结合WBC的细胞表面分子，第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原，并且其中通过CAR的拷贝数和/或释放的细胞因子(例如，IL-6和IFN-γ)的量来测量T细胞应答。在实施方案中，与包含第二CAR但不包含第一CAR的T细胞相比，所述T细胞应答增强。
11.根据实施方案10所述的方法，其中增强受试者中T细胞应答包括在体内选择性增强包含第一CAR和第二CAR的T细胞的增殖。
12.一种体内扩增表达CAR的细胞的方法，所述方法包括：
向受试者施用有效量的包含第一CAR和第二CAR的T细胞，其中第一CAR的结合结构域结合WBC的细胞表面分子，并且第二CAR的结合结构域结合不同于WBC的细胞表面分子的抗原，所述细胞是T细胞、NK细胞或树突状细胞。
13.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中不同于WBC的细胞表面分子的抗原是CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138、CD13、B7、CAIX、CD123、CD133、CD171、CD171/L1-CAM、CEA、Claudin 18.2、cMet、CS1、CSPG4、Dectin1、EGFR、EGFR vIII、EphA2、ERBB受体、ErbB T4、ERBB2、FAP、叶酸受体1、FITC、FSH、GD2、GPC3、HA-1H/HLA-A2、HER2、IL-11Ra、IL13受体a2、IL13R、IL13Rα2(zetakine)、Kappa、LewisY、间皮素、MUC1、NKG2D、NY-ESO-1、PSMA、ROR-1、TRAIL受体1或VEGFR2。
14.根据实施方案13所述的核酸、载体、细胞、组合物或方法，其中MUC1是人MUC1的肿瘤排他性表位，并且第一CAR和第二CAR表达为单独的多肽。
15.根据实施方案13所述的核酸、载体、细胞、组合物或方法，其中MUC1是人MUC1的肿瘤形式(tMUC1)。
16.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中WBC是粒细胞、单核细胞或淋巴细胞。
17.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中WBC是B细胞。
18.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中WBC的细胞表面分子是CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138或CD13。
19.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中WBC的细胞表面分子是CD19、CD20、CD22或BCMA。
20.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中WBC的细胞表面分子是CD19。
21.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域；和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
22.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中共刺激结构域包括以下的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
23.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中抗原结合结构域是Fab或scFv。
24.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中第一CAR包含SEQ ID NO:5、6、53和54、55和56、或57和58的氨基酸序列，并且第二CAR包含SEQ IDNO:5-17、29、33、37、71或72的氨基酸序列，或由核苷酸序列SEQ ID NO:41、45、63、67或68编码的氨基酸序列。
25.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中编码第一CAR的核酸包含SEQ ID NO:59或60的核酸序列，并且编码第二CAR的核酸序列包括SEQID NO:61的核酸序列。
26.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中核酸包含SEQ ID NO:62-69的核酸序列之一。
27.根据实施方案1-12中任一项所述的核酸、载体、细胞、组合物或方法，其中第一CAR和第二CAR表达为单独的多肽。
28.一种包含第一CAR和第二CAR的修饰的T细胞，其中第一CAR的结合结构域与CD19结合，并且第二CAR的结合结构域与肿瘤相关的MUC1结合。
29.根据实施方案28所述的修饰的T细胞，其中第二CAR的结合结构域包含：
(i)重链互补决定区1，其包含SEQ ID:76或85的氨基酸序列；重链互补决定区2，其包含SEQ ID:77或86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78或87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73或82的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)或SEQ ID:83的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75或84的氨基酸序列。
30.根据实施方案28所述的修饰的T细胞，其中第二CAR的结合结构域包含：
(i)重链互补决定区1，其包含SEQ ID:76的氨基酸序列；重链互补决定区2，其包含SEQ ID:77的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75的氨基酸序列。
31.根据实施方案28所述的修饰的T细胞，其中第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:85的氨基酸序列；重链互补决定区2，其包含SEQ ID:86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:82的氨基酸序列；轻链互补决定区2，其包含SEQ ID:83的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:84的氨基酸序列。
32.根据实施方案28所述的修饰的T细胞，其中第一CAR的结合结构域包含SEQ ID:5或6的氨基酸序列。
33.根据实施方案28所述的修饰的T细胞，其中第二CAR的结合结构域包含SEQ ID:70-72和79-81的氨基酸序列之一。
34.根据实施方案28-33中任一项所述的修饰的T细胞，其中第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域；和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
35.根据实施方案34所述的修饰的T细胞，其中共刺激结构域包括以下的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
36.根据实施方案28-35中任一项所述的修饰的T细胞，其中第一CAR和第二CAR表达为基因产物，所述基因产物是单独的多肽。
37.根据实施方案28-35中任一项所述的修饰的T细胞，其中第二CAR的细胞质结构域或跨膜结构域被修饰以使得第二CAR能够通过表达CD19的细胞激活修饰的T细胞，而不会损害表达CD19的细胞。
38.一种双特异性CAR，其包含：
第一抗原结合结构域、第二抗原结合结构域、细胞质结构域和跨膜结构域，其中第一抗原结合结构域识别第一抗原，第二抗原结合结构域识别第二抗原，并且第一抗原不同于第二抗原。
39.根据实施方案38所述的双特异性CAR，其中第一抗原和第二抗原不在相同细胞上表达。
40.根据实施方案38所述的双特异性CAR，其中第一抗原是血液组分的抗原，并且第二抗原是实体瘤的抗原。
41.根据实施方案38所述的双特异性CAR，其中第一抗原是CD19，并且第二抗原是肿瘤相关的MUC1。
42.根据实施方案38所述的双特异性CAR，其中第一抗原结合结构域包含SEQ ID:5或6的氨基酸序列。
43.根据实施方案28所述的修饰的T细胞，其中第二抗原结合结构域包含SEQ ID:70-72和79-81的氨基酸序列之一。
44.一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，所述方法包括：向受试者施用有效量的根据实施方案28-37中任一项所述的修饰的T细胞以提供T细胞应答，使得修饰的T细胞通过表达CD19的细胞在受试者血液中扩增。
45.根据实施方案28-37中任一项所述的修饰的T细胞，其中肿瘤相关的MUC1表达在肿瘤细胞上，但不表达在相应非恶性细胞上。
46.根据实施方案28-37中任一项所述的修饰的T细胞，其中第二CAR的结合结构域包含针对肿瘤相关的MUC1的scFv，所述scFv直接与邻糖基化的GSTA基序(SEQ ID NO.88)相互作用。
47.一种细胞，其包含根据实施方案38-43中任一项所述的双特异性CAR。
48.一种核酸，其编码根据实施方案38-43中任一项所述的双特异性CAR。
49.一种编码第一CAR和第二CAR的核酸，其中第一CAR的结合结构域与选自以下的抗原结合：CD19、CD33、CD14和BCMA，并且第二CAR的结合结构域与肿瘤相关的MUC1结合。
50.一种包含第一CAR和第二CAR的T细胞，其中第一CAR的结合结构域与选自以下的抗原结合：CD19、CD33、CD14和BCMA，第二CAR的结合结构域与肿瘤相关的MUC1结合。
51.一种包含编码第一CAR的第一核酸和编码第二CAR的第二核酸的T细胞，其中第一CAR的结合结构域与选自以下的抗原结合：CD19、CD33、CD14和BCMA，第二CAR的结合结构域与肿瘤相关的MUC1结合。
52.一种组合物，其包含根据实施方案50或51所述的T细胞群。
53.根据实施方案50或51所述的T细胞，其中第一CAR和第二CAR表达为单独的多肽。
54.根据实施方案1所述的核酸或根据实施方案50或51所述的T细胞，其中核酸包含SEQ ID NO:201、204、206、208、209、211、213-215、217、218、220-225、227、228、230-235、237、238、240-244、247、249-254、256、257、259和260-263的核酸序列之一。
55.根据实施方案49所述的核酸或根据实施方案50或51所述的T细胞，其中核酸包含SEQ ID NO:201、204、206、208、215、217、218和220的核酸序列之一。
56.根据实施方案49所述的核酸或根据实施方案50或51所述的细胞，其中第一CAR包含SEQ ID NO:203、207、216、219、226、229、236、239、245、248、255或258的氨基酸序列，并且第二CAR包含SEQ ID:202、205、210或212的氨基酸序列。
57.根据实施方案49所述的核酸或根据实施方案50或51所述的细胞，其中第一CAR包含SEQ ID NO:207的氨基酸序列，并且第二CAR包含SEQ ID NO:202的氨基酸序列。
58.根据实施方案49所述的核酸或根据实施方案50或51所述的细胞，其中第一CAR包含SEQ ID NO:203、207、216或219的氨基酸序列，并且第二CAR包含SEQ ID NO:202或205的氨基酸序列。
59.一种载体，其包含根据实施方案49所述的核酸。
60.一种细胞，其包含根据实施方案49所述的核酸。
61.一种组合物，其包含根据实施方案60所述的细胞群。
62.根据实施方案60或61所述的细胞，其中细胞是T细胞、NK细胞或树突状细胞。
63.一种基因修饰的T细胞，其包含一种或多种编码CAR的核酸以及先天T细胞的一个或多个TCR链或TCR。
64.根据实施方案63所述的基因修饰的T细胞，其中编码先天T细胞的一个或多个TCR链或TCR的核酸是靶基因组基因座内的核酸插入物。
65.根据实施方案63所述的基因修饰的T细胞，其中整合核酸插入物致使靶基因组基因座处基因的至少一部分置换。
66.根据实施方案63所述的基因修饰的T细胞，其中使用核酸酶剂将核酸引入T细胞中。
67.一种修饰T细胞中靶基因组基因座的方法，所述方法包括：将核酸酶剂引入T细胞中，所述核酸酶剂使得靶基因组基因座内的单链或双链断裂；和将核酸插入物引入T细胞中，所述核酸插入物包含编码先天T细胞的一个或多个TCR链或TCR的核酸；以及选择T细胞，所述T细胞包含整合到靶基因组基因座中的核酸插入物。
68.根据实施方案67所述的方法，其中核酸插入物的侧翼为5'同源臂和3'同源臂，并且核酸插入物的3'同源臂和核酸插入物的5'同源臂与靶基因组基因座内的相应基因组片段同源。
69.根据实施方案67所述的方法，其中通过将核酸插入物整合在相应基因组片段之间对靶基因组基因座进行修饰。
70.根据实施方案67所述的方法，其中核酸酶剂是锌指核酸酶(ZFN)、类转录激活因子效应子核酸酶(TALEN)或大范围核酸酶。
71.根据实施方案67所述的方法，其中核酸酶剂包含成簇的规律性间隔短回文重复序列(CRISPR)相关(Cas)蛋白和指导RNA(gRNA)。
72.根据实施方案71所述的方法，其中Cas蛋白是Cas9。
73.根据实施方案63-72中任一项所述的基因修饰的T细胞或方法，其中先天T细胞包括γδT细胞、iNKT细胞或MAIT细胞。
74.根据实施方案63-72中任一项所述的基因修饰的T细胞或方法，其中先天T细胞包括γδT细胞。
75.根据实施方案63-72中任一项所述的基因修饰的T细胞或方法，其中先天T细胞包括Vγ9Vδ2T细胞。
76.根据实施方案75所述的基因修饰的T细胞或方法，其中编码一个或多个TCR链的一种或多种核酸编码TCRγ链和TCRδ链。
77.根据实施方案75所述的基因修饰的T细胞或方法，其中编码一个或多个TCR链的一种或多种核酸编码内源性TCRγ链和内源性TCRδ链。
78.根据实施方案75所述的基因修饰的T细胞或方法，其中核酸插入物包含对应于SEQID No.:99和185或其组合的一种或多种氨基酸序列的核酸。
79.根据实施方案63-72中任一项所述的基因修饰的T细胞或方法，其中先天T细胞包括iNKT细胞。
80.根据实施方案79所述的基因修饰的T细胞或方法，其中编码先天T细胞的TCR的核酸编码iNKTα链和/或iNKTβ链。
81.根据实施方案79所述的基因修饰的T细胞或方法，其中编码先天T细胞的TCR的核酸编码内源性iNKTα链或内源性iNKTβ链。
82.根据实施方案63-72中任一项所述的基因修饰的T细胞或方法，其中先天T细胞包括MAIT细胞。
83.根据实施方案82所述的基因修饰的T细胞或方法，其中编码先天T细胞的TCR的核酸编码MAITα链和/或MAITβ链。
84.根据实施方案82所述的基因修饰的T细胞或方法，其中编码先天T细胞的TCR的核酸编码内源性MAITα链或内源性MAITβ链。
85.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中靶基因组基因座是αβT细胞的α或βTCR基因座。
86.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中整合核酸插入物以使αβT细胞的α或βTCR基因座处的序列置换，从而使得整体内源性TCR的表达不减少。
87.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中靶基因组基因座的相应基因组片段包含TCRα链的氨基酸序列。
88.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中与不包含核酸序列的相应细胞相比，基因修饰的细胞针对同种异体细胞引发的移植物抗宿主疾病应答减少。
89.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中T细胞是衍生自原代人T细胞的T细胞，所述原代人T细胞从人类供体中分离得到。
90.根据实施方案63-84中任一项所述的基因修饰的T细胞或方法，其中T细胞包含CAR。
91.根据实施方案63-90中任一项所述的基因修饰的细胞或方法，其中基因修饰的细胞具有包含一个或多个TCR链的功能性TCR。
92.根据实施方案63-90中任一项所述的基因修饰的细胞或方法，其中先天T细胞的TCR和αβTCR来源于供体。
93.根据实施方案63-92中任一项所述的基因修饰的细胞或方法，其中先天T细胞对抗原识别表现出非MHC I类或II类限制要求。
94.一种在受试者中引起T细胞应答或治疗受试者肿瘤的方法，所述方法包括：施用有效量的根据实施方案63-92中任一项所述的T细胞。
95.一种编码结合分子的核酸，所述结合分子包含第一结构域和第二结合结构域，其中第一结合结构域和第二结合结构域与抗原结合。
96.根据实施方案95所述的核酸，其中第一结合结构域和第二结合结构域的一个或多个靶向抗原结合位点是不同的，并且结合分子是包含以下的CAR：第一结合结构域、接头、第二结合结构域、跨膜结构域和共刺激结构域和/或CD3ζ结构域。
97.根据实施方案95所述的核酸，其中抗原是表皮生长因子受体(EGFR)、表皮生长因子受体的变体III(EGFRvIII)、人表皮生长因子受体2(HER2)、间皮素(MSLN)、前列腺特异性膜抗原(PSMA)、癌胚抗原(CEA)、双唾液酸神经节苷脂2(GD2)、白介素-13Ra2(IL13Rα2)、磷脂酰肌醇蛋白聚糖-3(GPC3)、碳酸酐酶IX(CAIX)、L1细胞粘附分子(L1-CAM)、癌症抗原125(CA125)、分化簇133(CD133)、成纤维细胞活化蛋白(FAP)、癌症/睾丸抗原1B(CTAG1B)、粘蛋白1(MUC1)、叶酸受体α(FR-α)、CD19、FZD10、TSHR、PRLR、粘蛋白17(MUC17)、GUCY2C、CD207、CD3、CD5、B细胞成熟抗原(BCMA)或CD4。
98.根据实施方案95所述的核酸，其中第一结合结构域与肿瘤相关Muc1、TSHR、FZD10、PRLR、粘蛋白16(MUC16)、MUC17、GUCY2C、CD207、CLDN18.2、CLDN6或SIGL1C结合。
99.根据实施方案95所述的核酸，其中核酸编码包含SEQ ID NO:264和265的氨基酸序列之一的多肽。
100.一种载体，其包含根据实施方案95-99中任一项所述的核酸。
101.一种宿主细胞，其用根据实施方案95-99中任一项所述的核酸或用根据实施方案100所述的载体进行转化或转染。
102.一种用于产生由根据实施方案95-99中任一项所述的核酸编码的结合分子的方法，所述方法包括在允许表达根据实施方案95-99中任一项所述的结合分子的条件下培养根据实施方案101所述的宿主细胞，以及从培养物中回收结合分子。
103.一种药物组合物，其包含由根据实施方案95-99中任一项所述的核酸编码或根据实施方案102所述的方法产生的结合分子。
104.一种试剂盒，其包含由根据实施方案95-99中任一项所述的核酸编码的结合分子、根据实施方案95-99中任一项所述的核酸、根据实施方案100所述的载体和/或根据实施方案101所述的宿主细胞。
105.一种用于治疗或改善疾病的方法，所述方法包括向有需要的受试者施用由根据实施方案95-99中任一项所述的核酸编码的结合分子。
106.一种编码第一抗原结合分子和第二抗原结合分子的核酸，其中第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的实体瘤抗原。
107.一种载体，其包含根据实施方案106所述的核酸。
108.一种细胞，其包含根据实施方案106所述的核酸。
109.一种包含第一抗原结合分子和第二抗原结合分子的细胞，其中第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的实体瘤抗原。
110.一种组合物，其包含根据实施方案108-109中任一项所述的细胞群。
111.根据实施方案108-109中任一项所述的细胞，其中细胞是T细胞、NK细胞或树突状细胞。
112.一种培养细胞的方法，所述方法包括：获得包含第一抗原结合分子和第二抗原结合分子的细胞，其中第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的实体瘤抗原；以及在衍生自WBC的细胞表面分子或衍生自第二抗原结合分子结合的抗原的试剂存在下培养细胞。
113.根据实施方案112所述的方法，其中试剂是WBC的细胞表面分子的细胞外结构域。
114.一种用于体外细胞制备的方法，所述方法包括：准备好细胞；将编码第一抗原结合分子和第二抗原结合分子的核酸引入细胞中，第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的抗原；以及在衍生自WBC的细胞表面分子或衍生自第二抗原结合分子结合的抗原的试剂存在下培养细胞。
115.一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，所述方法包括：向受试者施用有效量的T细胞以提供T细胞应答，所述T细胞包含第一抗原结合分子和第二抗原结合分子，其中第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的抗原。
116.根据实施方案115所述的方法，其中增强受试者中T细胞应答包括在体内选择性增强包含第一抗原结合分子和第二抗原结合分子的T细胞的增殖。
117.一种体内扩增表达抗原结合分子的方法，所述方法包括：向受试者施用有效量的T细胞，所述T细胞包含第一抗原结合分子和第二抗原结合分子，其中第一抗原结合分子的结合结构域结合WBC的细胞表面分子，并且第二抗原结合分子的结合结构域结合不同于WBC的细胞表面分子的实体瘤抗原，细胞是T细胞、NK细胞或树突状细胞。
118.根据实施方案106-117中任一项所述的核酸、载体、细胞或方法，其中第一抗原结合分子是第一嵌合抗原受体(CAR)并且第二抗原结合分子是第二CAR。
119.根据实施方案118所述的核酸、载体、细胞或方法，其中不同于WBC的细胞表面分子的抗原是CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138、CD13、B7、CAIX、CD123、CD133、CD171、CD171/L1-CAM、CEA、Claudin 18.2、cMet、CS1、CSPG4、Dectin1、EGFR、EGFR vIII、EphA2、ERBB受体、ErbBT4、ERBB2、FAP、叶酸受体1、FITC、FSH、GD2、GPC3、HA-1H/HLA-A2、HER2、IL-11Ra、IL13受体a2、IL13R、IL13Rα2(zetakine)、Kappa、LewisY、间皮素、MUC1、NKG2D、NY-ESO-1、PSMA、ROR-1、TRAIL受体1或VEGFR2。
120.根据实施方案118所述的核酸、载体、细胞或方法，其中MUC1是人MUC1的肿瘤排他性表位，并且第一CAR和第二CAR表达为多肽。
121.根据实施方案118所述的核酸、载体、细胞或方法，其中MUC1是人MUC1的肿瘤形式(tMUC1)。
122.根据实施方案118所述的核酸、载体、细胞或方法，其中WBC是粒细胞、单核细胞和/或淋巴细胞。
123.根据实施方案118所述的核酸、载体、细胞或方法，其中WBC是B细胞。
124.根据实施方案118所述的核酸、载体、细胞或方法，其中WBC的细胞表面分子是CD19、CD22、CD20、BCMA、CD5、CD7、CD2、CD16、CD56、CD30、CD14、CD68、CD11b、CD18、CD169、CD1c、CD33、CD38、CD138或CD13，或WBC的细胞表面分子是CD19、CD20、CD22或BCMA。
125.根据实施方案118所述的核酸、载体、细胞或方法，其中WBC的细胞表面分子是CD19。
126.根据实施方案118所述的核酸、载体、细胞或方法，其中第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域；和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
127.根据实施方案110所述的核酸、细胞或方法，其中共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
128.根据实施方案118所述的核酸、载体、细胞或方法，其中抗原结合结构域是Fab或scFv。
129.根据实施方案118所述的核酸、载体、细胞或方法，其中第一CAR包含SEQ IDNO:5、6、53和54、55和56、或57和58的氨基酸序列，并且第二CAR包含SEQ ID NO:5-17、29、33、37、71和72之一的氨基酸序列，或由具有SEQ ID NO:41、45、63、67或68的核酸编码的氨基酸序列。
130.根据实施方案118所述的核酸、载体、细胞或方法，其中编码第一CAR的核酸包含SEQ ID NO:59或60的核酸序列，并且编码第二CAR的核酸包括SEQ ID NO:61的核酸序列。
131.根据实施方案118所述的核酸、载体、细胞或方法，其中核酸包含SEQ ID NO:62-69的核酸序列之一。
132.根据实施方案118所述的核酸、载体、细胞或方法，其中第一CAR和第二CAR表达为基因产物，所述基因产物是单独的多肽。
133.根据实施方案106-132中任一项所述的核酸、载体、细胞或方法，其中第一抗原结合分子是嵌合抗原受体(CAR)并且第二抗原结合分子是T细胞受体(TCR)。
134.根据实施方案133所述的核酸、载体、细胞或方法，其中TCR是修饰的TCR。
135.根据实施方案133所述的核酸、载体、细胞或方法，其中TCR衍生自患者中自发产生的肿瘤特异性T细胞。
136.根据实施方案133所述的核酸、细胞或方法，其中TCR与肿瘤抗原结合。
137.根据实施方案133所述的核酸、载体、细胞或方法，其中肿瘤抗原包括CEA、gp100、MART-1、p53、MAGE-A3或NY-ESO-1，或TCR包含TCRγ和TCRδ链或TCRα和TCRβ链、或其组合。
138.一种包含第一CAR和第二CAR的修饰的T细胞，其中第一CAR的结合结构域与CD19结合，并且第二CAR的结合结构域与肿瘤相关的MUC1结合。
139.根据实施方案138所述的修饰的T细胞，其中第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:76或85的氨基酸序列；重链互补决定区2，其包含SEQ ID:77或86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78或87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73或82的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)或SEQ ID:83的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75或84的氨基酸序列。
140.根据实施方案138所述的修饰的T细胞，其中第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:76的氨基酸序列；重链互补决定区2，其包含SEQ ID:77的氨基酸序列；和重链互补决定区3，其包含SEQ ID:78的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:73的氨基酸序列；轻链互补决定区2，其包含TRP-ALA-SER(WAS)的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:75的氨基酸序列。
141.根据实施方案138所述的修饰的T细胞，其中第二CAR的结合结构域包含：(i)重链互补决定区1，其包含SEQ ID:85的氨基酸序列；重链互补决定区2，其包含SEQ ID:86的氨基酸序列；和重链互补决定区3，其包含SEQ ID:87的氨基酸序列；以及(ii)轻链互补决定区1，其包含SEQ ID:82的氨基酸序列；轻链互补决定区2，其包含SEQ ID:83的氨基酸序列；和轻链互补决定区3，其包含SEQ ID:84的氨基酸序列。
142.根据实施方案138所述的修饰的T细胞，其中第一CAR的结合结构域包含SEQID:5或6的氨基酸序列。
143.根据实施方案138所述的修饰的T细胞，其中第二CAR的结合结构域包含SEQID:70-72和79-81的氨基酸序列之一。
144.根据实施方案138-143中任一项所述的修饰的T细胞，其中第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域；和/或第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
145.根据实施方案144所述的修饰的T细胞，其中共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
146.根据实施方案138-145中任一项所述的修饰的T细胞，其中第一CAR和第二CAR表达为基因产物，所述基因产物是单独的多肽。
147.根据实施方案138-146中任一项所述的修饰的T细胞，其中第二CAR的细胞质结构域或跨膜结构域被修饰以使得第二CAR能够通过表达CD19的细胞激活修饰的T细胞，而不会损害表达CD19的细胞。
148.一种双特异性嵌合抗原受体，其包含：第一抗原结合结构域、第二抗原结合结构域、细胞质结构域和跨膜结构域，其中第一抗原结合结构域识别第一抗原，并且第二抗原结合结构域识别第二抗原，第一抗原不同于第二抗原。
149.根据实施方案148所述的双特异性嵌合抗原受体，其中第一抗原和第二抗原不在相同细胞上表达。
150.根据实施方案148或149所述的双特异性嵌合抗原受体，其中第一抗原是血液组分的抗原，并且第二抗原是实体瘤的抗原。
151.根据实施方案148-150中任一项所述的双特异性嵌合抗原受体，其中第一抗原是CD19，并且第二抗原是肿瘤相关的MUC1。
152.根据实施方案148-151中任一项所述的双特异性嵌合抗原受体，其中第一抗原结合结构域包含SEQ ID:5和6的氨基酸序列之一。
153.根据实施方案138-147中任一项所述的修饰的T细胞，其中第二抗原结合结构域包含SEQ ID:70-72和79-81的氨基酸序列之一。
154.一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，所述方法包括：向受试者施用有效量的根据实施方案138-147中任一项所述的修饰的T细胞以提供T细胞应答，使得CAR T细胞通过表达CD19的细胞在受试者血液中扩增。
155.根据实施方案138-147中任一项所述的修饰的T细胞，其中肿瘤相关的MUC1表达在肿瘤细胞上，但不表达在相应非恶性细胞上。
156.根据实施方案138-147中任一项所述的修饰的T细胞，其中针对肿瘤相关的MUC1的scFv直接与邻糖基化的GSTA基序(SEQ ID NO.88)相互作用。
157.一种细胞，其包含根据实施方案148-152中任一项所述的双特异性CAR。
158.一种核酸，其编码根据实施方案148-152中任一项所述的双特异性CAR。
159.一种包含第一CAR和第二CAR的T细胞，其中第一CAR的抗原结合结构域与选自以下的抗原结合：CD19、CD33、CD14和BCMA，并且第二CAR的抗原结合结构域与肿瘤相关的MUC1结合。
160.根据实施方案159所述的T细胞，其中第一CAR包含SEQ ID NO:207的氨基酸序列，并且第二CAR包含SEQ ID NO:202的氨基酸序列。
161.根据实施方案159所述的T细胞，其中第一CAR包含SEQ ID NO:203、207、216或219的氨基酸序列，并且第二CAR包含SEQ ID:202或205的氨基酸序列。
162.根据实施方案159所述的T细胞，其中第二CAR的抗原结合结构域包含SEQ IDNO:70的氨基酸序列。
163.根据实施方案159所述的T细胞，其中第二CAR的抗原结合结构域包含SEQ IDNO:5或6的氨基酸序列。
164.根据实施方案159所述的T细胞，其中分离的T细胞包含SEQ ID NO:201、204、206、208、215、217、218和220的核酸序列之一。
165.根据实施方案159-164中任一项所述的T细胞，其中第一CAR和第二CAR各自包含抗原结合结构域、跨膜结构域和细胞质结构域。
166.根据实施方案165所述的T细胞，其中细胞质结构域包含共刺激结构域和CD3ζ结构域。
167.根据实施方案166所述的T细胞，其中共刺激结构域包括以下的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
168.根据实施方案159所述的T细胞，其中T细胞包含以下受体的显性失活变体：程序性死亡1(PD-1)、细胞毒性T淋巴细胞抗原-4(CTLA-4)、B淋巴细胞和T淋巴细胞弱化因子(BTLA)、T细胞免疫球蛋白粘蛋白-3(TIM-3)、淋巴细胞激活蛋白3(LAG-3)、具有Ig和ITIM结构域的T细胞免疫受体(TIGIT)、白细胞相关的免疫球蛋白样受体1(LAIR1)、自然杀伤细胞受体2B4(2B4)或CD 160。
169.根据实施方案159所述的T细胞，其中与相应的野生型T细胞相比，T细胞包含减少量的TCR。
170.一种组合物，其包含根据实施方案159-169中任一项所述的T细胞群。
171.一种增强受试者中T细胞应答或治疗受试者肿瘤的方法，所述方法包括：施用有效量的根据实施方案159-169中任一项所述的T细胞。
172.根据实施方案1-171中任一项所述的核酸、载体、细胞(包括T细胞和修饰的T细胞)、双特异性CAR、组合物或方法，其中肿瘤抗原是实体瘤抗原。
173.根据实施方案1-172中任一项所述的核酸、载体、细胞(包括T细胞和修饰的T细胞)、双特异性CAR、组合物或方法，其中实体瘤抗原是tMUC 1、PRLR、CLCA1、MUC12、GUCY2C、GPR35、CR1L、MUC 17、TMPRSS11B、MUC21、TMPRSS11E、CD207、SLC30A8、CFC1、SLC12A3、SSTR1、GPR27、FZD10、TSHR、SIGLEC15、SLC6A3、KISS1R、QRFPR、GPR119、CLDN6、UPK2、ADAM12、SLC45A3、ACPP、MUC21、MUC16、MS4A12、ALPP、CEA、EphA2、FAP、GPC3、IL13-Rα2、间皮素、PSMA、ROR1、VEGFR-II、GD2、FR-α、ErbB2、EpCAM、EGFRvIII或EGFR，并且其中B细胞抗原是CD19、CD20、CD22或BCMA。
174.一种用于增强患有癌症的受试者中T细胞扩增和/或细胞因子释放(例如，IL-6和INF-γ)的方法，所述方法包括：将多种核酸提供到T细胞中，所述多种核酸编码结合实体瘤抗原的嵌合抗原受体(CAR)，并且编码结合B细胞抗原的CAR；以及向受试者施用有效量的T细胞。
175.一种用于增强患有癌症的受试者中T细胞应答和/或细胞因子释放(例如，IL-6和INF-γ)的方法，所述方法包括：将多种核酸提供到T细胞中，所述多种核酸编码：结合实体瘤抗原的嵌合抗原受体(CAR)，结合B细胞抗原的CAR以及缺乏功能性PD-1细胞内结构域的修饰的PD-1；以及向受试者施用有效量的T细胞。
176.一种修饰的细胞，其包含多种核酸，所述多种核酸编码：结合与受试者肿瘤相关的实体瘤抗原的嵌合抗原受体(CAR)、结合B细胞抗原的CAR以及缺乏功能性PD-1细胞内结构域的修饰的PD-1。
177.根据实施方案175或176所述的修饰的细胞或方法，其中与施用有效量的不具有结合B细胞抗原的CAR或修饰的PD-1D的CAR T细胞的受试者相比，所述受试者具有更高水平的T细胞扩增和更高量的记忆T细胞。
178.根据实施方案175或176所述的修饰的细胞或方法，其中修饰的PD-1D包含SEQIDNO:89-95的氨基酸序列之一。
179.根据实施方案174-178中任一项所述的修饰的细胞或方法，其中实体瘤抗原是tMUC1、PRLR、CLCA1、MUC12、GUCY2C、GPR35、CR1L、MUC 17、TMPRSS11B、MUC21、TMPRSS11E、CD207、SLC30A8、CFC1、SLC12A3、SSTR1、GPR27、FZD10、TSHR、SIGLEC15、SLC6A3、KISS1R、QRFPR、GPR119、CLDN6、UPK2、ADAM12、SLC45A3、ACPP、MUC21、MUC16、MS4A12、ALPP、CEA、EphA2、FAP、GPC3、IL13-Rα2、间皮素、PSMA、ROR1、VEGFR-II、GD2、FR-α、ErbB2、EpCAM、EGFRvIII或EGFR，并且B细胞抗原是CD19、CD20、CD22或BCMA。
180.根据实施方案174-178中任一项所述的修饰的细胞或方法，其中B细胞抗原包括CD19。
181.根据实施方案180所述的修饰的细胞或方法，其中实体瘤抗原包括肿瘤相关MUC1。
182.根据实施方案181所述的修饰的细胞或方法，其中结合B细胞抗原的CAR的结合结构域包含SEQ ID NO:5或6的氨基酸序列，并且结合实体瘤抗原的CAR的结合结构域包含SEQ ID NO:70的氨基酸序列。
183.根据实施方案181所述的修饰的细胞或方法，其中结合B细胞抗原的CAR包含SEQID NO:207的氨基酸序列，并且结合实体瘤抗原的CAR包含SEQ ID NO:202的氨基酸序列。
184.根据实施方案181所述的修饰的细胞或方法，其中结合B细胞抗原的CAR包含抗原结合结构域、跨膜结构域、细胞质结构域，并且结合实体瘤抗原的CAR包含抗原结合结构域、跨膜结构域和细胞质结构域。
185.根据实施方案184所述的修饰的细胞或方法，其中CAR的细胞质结构域包含共刺激结构域或CD3ζ结构域或其组合。
186.根据实施方案180所述的修饰的细胞或方法，其中T细胞扩增大于通过在不存在结合B细胞抗原的CAR的情况下施用具有结合实体肿瘤抗原的CAR的T细胞而获得的T细胞扩增。
187.根据实施方案186所述的修饰的细胞或方法，其中基于T细胞基因组DNA中CAR分子拷贝数的增加来测量T细胞扩增。
188.根据实施方案180所述的修饰的细胞或方法，其中，至少一种核酸包含SEQ IDNO:201的核酸序列。
189.根据实施方案178所述的修饰的细胞或方法，其中B细胞抗原包括CD19、CD20、CD22或BCMA。
190.根据实施方案188所述的修饰的细胞或方法，其中实体瘤抗原包括B7、CAIX、CD123、CD133、CD171、CD171/L1-CAM、CEA、Claudin 18.2、cMet、CS1、CSPG4、Dectin1、EGFR、EGFR vIII、EphA2、ERBB受体、ErbB T4、ERBB2、FAP、叶酸受体1、FITC、FSH、GD2、GPC3、HA-1H/HLA-A2、HER2、IL-11Ra、IL13受体a2、IL13R、IL13Rα2(zetakine)、Kappa、LewisY、间皮素、MUC1、NKG2D、NY-ESO-1、PSMA、ROR-1、TRAIL-受体1或VEGFR2。
191.根据实施方案178所述的修饰的细胞或方法，其中结合B细胞抗原的CAR包含SEQID NO:203、207、216或219的氨基酸序列。
192.根据实施方案178所述的修饰的细胞或方法，其中结合实体瘤抗原的CAR包含SEQID NO:202或205的氨基酸序列。
193.根据实施方案178所述的修饰的细胞或方法，其中，核酸中的至少一种包含SEQ IDNO:201、204、206、208、215、217、218或220的核酸序列。
194.一种在患有癌症的受试者中增加免疫细胞亚群的数量或比率和/或增加或延长免疫细胞亚群的持久性的方法，所述方法包括：向受试者施用有效量的包含T细胞的组合物，所述T细胞包含嵌合抗原受体(CAR)和修饰的PD-1，所述修饰的PD-1缺乏功能性PD-1细胞内结构域；以及监测受试者中的T细胞应答，免疫细胞亚群包括初始(naive)T细胞、干细胞记忆T细胞和/或中央记忆T细胞，其中与不包含修饰的PD-1的相应T细胞相比，受试者中的免疫细胞亚群的数量或比率增加；或监测受试者中的免疫细胞亚群的持久性与不包含修饰的PD-1的相应T细胞相比是否有所增加或延长。
195.根据实施方案194所述的方法，其中监测受试者中的T细胞应答包括以下的至少一种：检测修饰的PD-1的mRNA；检测一种或多种白细胞的数量；检测初始T细胞、干细胞记忆T细胞和中央记忆T细胞中的至少一种的数量；检测CAR拷贝数；检测CD3阳性细胞数量；检测表达CAR的T细胞数量；以及检测一种或多种细胞因子的水平。
196.根据实施方案194所述的方法，其中与引入CAR但不包含修饰的PD-1的T细胞相比，所述T细胞在受试者中具有更多的记忆T细胞。
197.根据实施方案194所述的方法，其中修饰的PD-1包含SEQ ID:89-93的一种序列或修饰的PD-1不包含SEQ ID:94或95。
198.根据实施方案194所述的方法，其中T细胞包含PD-1的显性失活变体，并且T细胞的PD-1的内源基因不被破坏。
199.根据实施方案194所述的方法，其中CAR包含细胞外结构域、跨膜结构域和细胞内结构域，细胞外结构域与抗原结合。
200.根据实施方案199所述的方法，其中细胞内结构域包含共刺激结构域，所述共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
201.根据实施方案199所述的方法，其中抗原是表皮生长因子受体(EGFR)、表皮生长因子受体的变体III(EGFRvIII)、人表皮生长因子受体2(HER2)、间皮素(MSLN)、前列腺特异性膜抗原(PSMA)、癌胚抗原(CEA)、双唾液酸神经节苷脂2(GD2)、白介素-13Ra2(IL13Rα2)、磷脂酰肌醇蛋白聚糖-3(GPC3)、碳酸酐酶IX(CAIX)、L1细胞粘附分子(L1-CAM)、癌症抗原125(CA125)、分化簇133(CD133)、成纤维细胞活化蛋白(FAP)、癌症/睾丸抗原1B(CTAG1B)、粘蛋白1(MUC1)、叶酸受体α(FR-α)、CD19、FZD10、TSHR、PRLR、Muc 17、GUCY2C、CD207、CD3、CD5、B细胞成熟抗原(BCMA)或CD4。
202.根据实施方案194所述的方法，其中T细胞包含结合实体瘤抗原的CAR和结合白细胞抗原的CAR。
203.根据实施方案202所述的方法，其中实体瘤抗原是tMUC 1、PRLR、CLCA1、MUC12、GUCY2C、GPR35、CR1L、MUC 17、TMPRSS11B、MUC21、TMPRSS11E、CD207、SLC30A8、CFC1、SLC12A3、SSTR1、GPR27、FZD10、TSHR、SIGLEC15、SLC6A3、KISS1R、QRFPR、GPR119、CLDN6、UPK2、ADAM12、SLC45A3、ACPP、MUC21、MUC16、MS4A12、ALPP、CEA、EphA2、FAP、GPC3、IL13-Rα2、间皮素、PSMA、ROR1、VEGFR-II、GD2、FR-α、ErbB2、EpCAM、EGFRvIII或EGFR，并且B细胞抗原是CD19、CD20、CD22或BCMA。
204.根据实施方案202所述的方法，其中白细胞抗原是B细胞抗原。
205.根据实施方案202所述的方法，其中B细胞抗原是CD19、CD20、CD22或BCMA。
206.一种用于增加免疫细胞亚群的数量或比率和/或增加或延长免疫细胞亚群的持久性的方法，所述方法包括：提供具有编码嵌合抗原受体(CAR)的核酸序列的T细胞；以及提供具有编码修饰的PD-1的核酸序列的T细胞，所述修饰的PD-1缺乏功能性PD-1细胞内结构域，免疫细胞亚群包括初始T细胞、干细胞记忆T细胞和/或中央记忆T细胞，其中与不包含修饰的PD-1的相应T细胞相比，免疫细胞亚群的数量或比率增加；或监测免疫细胞亚群的持久性与不包含修饰的PD-1的相应T细胞相比是否有所增加或延长。
207.一种分离的锌指核酸酶(ZFN)，其包含：与CTLA4基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与CTLA4基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ IDNOS.:301、302和303，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:305、306和307。
208.一种分离的ZFN，其与CTLA4基因中的靶位点结合，所述靶位点包含SEQ IDNO.:304的核苷酸序列。
209.一种分离的锌指核酸酶(ZFN)，其包含：与LAG3基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与LAG3基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:308、309和310，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:309、308和312，或第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:313、314和315，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:316、317和318。
210.一种分离的ZFN，其与LAG3基因中的靶位点结合，所述靶位点包含SEQ IDNO.:311或319的核苷酸序列。
211.一种分离的锌指核酸酶(ZFN)，其包含：与BTLA基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与BTLA基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:320、321和322，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:323、324和325。
212.一种分离的ZFN，其与BTLA基因中的靶位点结合，所述靶位点包含SEQ IDNO.:326的核苷酸序列。
213.一种分离的锌指核酸酶(ZFN)，其包含：与TIM3基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与TIM3基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:327、328和329，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:330、331和332；或第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:334、335和336，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:337、338和339。
214.一种分离的ZFN，其与TIM3基因中的靶位点结合，所述靶位点包含SEQ IDNO.:333或340的核苷酸序列。
215.一种分离的锌指核酸酶(ZFN)，其包含：与FOXP3基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与FOXP3基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ IDNOS.:341、328和342，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:343、344和345，第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:347、348和349，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:350、344和351；或第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:288、310和314，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:308、309和284。
216.一种分离的ZFN，其与FOXP3基因中的靶位点结合，所述靶位点包含SEQ IDNO.:346、352或283的核苷酸序列。
217.一种分离的锌指核酸酶(ZFN)，其包含：与SIVA1基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与SIVA1基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:353、331和354，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:355、300和299；或第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:308、314和312，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:288、287和286。
218.一种分离的ZFN，其与SIVA1基因中的靶位点结合，所述靶位点包含SEQ IDNO.:296或285的核苷酸序列。
219.一种分离的锌指核酸酶(ZFN)，其包含：与LGALS9基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与LGALS9基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ IDNOS.:298、324和297，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:295、300和294。
220.一种分离的ZFN，其与CD33基因中的靶位点结合，所述靶位点包含SEQ IDNO.:293的核苷酸序列。
221.一种分离的锌指核酸酶(ZFN)，其包含：与CD33基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与CD33基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含从第一ZFP的N末端至第一ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:301、292和312，并且第二ZFP包含从第二ZFP的N末端至第二ZFP的C末端顺序排列的氨基酸序列SEQ ID NOS.:291、290和310。
222.一种分离的ZFN，其与LGALS9基因中的靶位点结合，所述靶位点包含SEQ IDNO.:289的核苷酸序列。
223.根据实施方案207-222中任一项所述的分离的ZFN，其中基因是人类基因。
224.根据实施方案207-222中任一项所述的分离的ZFN，其中切割结构域包括野生型或工程化的FokI切割结构域。
225.一种多核苷酸，其编码根据实施方案207-222中任一项所述的分离的ZFN。
226.一种载体，其包含根据实施方案225所述的多核苷酸。
227.根据实施方案226所述的载体，其中载体是腺病毒或慢病毒载体。
228.一种分离的细胞或细胞系，其包含根据实施方案207-222中任一项所述的分离的ZFN。
229.根据实施方案228所述的分离的细胞或细胞系，其中分离的细胞是干细胞、T细胞或自然杀伤(NK)细胞。
230.根据实施方案228所述的分离的细胞或细胞系，其中细胞是一种T细胞，所述T细胞衍生自从人类供体中分离的原代人T细胞。
231.根据实施方案228所述的分离的细胞或细胞系，其中细胞对以下的内源基因的表达减少：CTLA4、LAG3、BTLA、TIM3、FOXP3、SIVA1和LGALS9。
232.一种分离的细胞或细胞系，其包含编码嵌合抗原受体(CAR)的分离的核酸序列，其中使用根据实施方案207-222中任一项所述的ZFN使内源基因失活。
233.根据实施方案232所述的分离的细胞或细胞系，其中CAR包含抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ信号传导结构域。
234.根据实施方案233所述的分离的细胞或细胞系，与原代人T细胞的移植物抗宿主疾病(GVHD)应答相比，所述细胞在生物不相容的人受体中的GVHD应答降低。
235.根据实施方案232所述的分离的细胞或细胞系，其中CAR的抗原结合结构域与FZD10、TSHR、PRLR、Muc17、GUCY2C、CD207、CD19或CD20结合。
236.根据实施方案232所述的分离的细胞或细胞系，其中CAR的共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
237.根据实施方案228所述的分离的细胞或细胞系，其中分离的细胞或细胞系是包含编码hTERT的核酸序列、或编码SV40LT的核酸或其组合的T细胞。
238.根据实施方案237所述的分离的细胞或细胞系，其中T细胞包含编码hTERT的核酸序列和编码SV40LT的核酸。
239.根据实施方案237所述的分离的细胞或细胞系，其中hTERT的表达由诱导型表达系统调节。
240.根据实施方案237所述的分离的细胞或细胞系，其中SV40LT基因的表达由诱导型表达系统调节。
241.根据实施方案240所述的分离的细胞或细胞系，其中诱导型表达系统是rTTA-TRE，其增加或激活SV40LT基因或hTERT基因或其组合的表达。
242.根据实施方案237所述的分离的细胞或细胞系，其中T细胞包含编码自杀基因的核酸序列，和/或自杀基因包括HSV-TK自杀基因系统。
243.一种治疗受试者中的癌症的方法，所述方法包括向受试者施用根据实施方案232所述的基因修饰的细胞，其中癌症选自以下：肺癌、胰腺癌、肝癌、骨癌、乳癌、结肠直肠癌、白血病、卵巢癌、淋巴瘤和脑癌。
244.一种分离的锌指核酸酶(ZFN)，其包含：与B2M基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与B2M基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP包含列于表8中的氨基酸序列，并且第二ZFP包含列于表8中的氨基酸序列。
245.一种分离的ZFN，其与B2M基因中的靶位点结合，所述靶位点包含列于表8中的核苷酸序列。
246.一种分离的锌指核酸酶(ZFN)，其包含：与CIITA基因中的第一靶位点结合的第一锌指蛋白(ZFP)，所述第一ZFP包含三个或更多个锌指结构域；与CIITA基因中的第二靶位点结合的第二ZFP，所述第二ZFP包含三个或更多个锌指结构域；以及切割结构域，其中第一ZFP和第二ZFP包含列于表8中的氨基酸序列。
247.根据实施方案244-246中任一项所述的分离的ZFN，其中基因是人类基因。
248.根据实施方案244-246中任一项所述的分离的ZFN，其中切割结构域包括野生型或工程化的FokI切割结构域。
249.一种多核苷酸，其编码根据实施方案244-248中任一项所述的分离的ZFN。
250.一种载体，其包含根据实施方案249所述的多核苷酸。
251.根据实施方案250所述的载体，其中载体是腺病毒或慢病毒载体。
252.一种分离的细胞或细胞系，其包含根据实施方案244-248中任一项所述的分离的ZFN。
253.根据实施方案252所述的分离的细胞或细胞系，其中分离的细胞是干细胞、T细胞或自然杀伤(NK)细胞。
254.根据实施方案253所述的分离的细胞或细胞系，其中细胞是一种T细胞，所述T细胞衍生自从人类供体中分离的原代人T细胞。
255.根据实施方案254所述的分离的细胞或细胞系，其中细胞对B2M或CIITA的内源基因的表达减少。
256.一种分离的细胞，其包含编码嵌合抗原受体(CAR)的分离的核酸序列，其中使用根据实施方案244-256中任一项所述的ZFN使CAR的内源基因失活。
257.根据实施方案256所述的分离的细胞或细胞系，其中CAR包含抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ信号传导结构域。
258.根据实施方案257所述的分离的细胞或细胞系，与原代人T细胞的宿主抗移植物疾病(HVGD)应答相比，所述细胞在生物不相容的人受体中的HVGD应答降低。
259.根据实施方案258所述的分离的细胞或细胞系，其中CAR的抗原结合结构域与FZD10、TSHR、PRLR、Muc17、GUCY2C、CD207、CD19或CD20结合。
260.根据实施方案258所述的分离的细胞或细胞系，其中CAR的共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
261.根据实施方案260所述的分离的细胞或细胞系，其中分离的细胞或细胞系是包含编码hTERT的核酸序列、或编码SV40LT的核酸或其组合的T细胞。
262.根据实施方案261所述的分离的细胞或细胞系，其中T细胞包含编码hTERT的核酸序列和编码SV40LT的核酸。
263.根据实施方案262所述的分离的细胞或细胞系，其中hTERT的表达由诱导型表达系统调节。
264.根据实施方案262所述的分离的细胞或细胞系，其中SV40LT基因的表达由诱导型表达系统调节。
265.根据实施方案264所述的分离的细胞或细胞系，其中诱导型表达系统是rTTA-TRE，其增加或激活SV40LT基因或hTERT基因或其组合的表达。
266.根据实施方案262所述的分离的细胞或细胞系，其中T细胞包含编码自杀基因的核酸序列，和/或自杀基因包括HSV-TK自杀基因系统。
267.一种治疗受试者中的癌症的方法，所述方法包括向受试者施用根据实施方案25所述的基因修饰的细胞，其中癌症选自以下：肺癌、胰腺癌、肝癌、骨癌、乳癌、结肠直肠癌、白血病、卵巢癌、淋巴瘤和脑癌。
268.一种修饰的细胞，其与相应的野生型细胞相比包含减少量的主要组织相容性复合物II(MHC II)，其中与相应的野生型细胞相比，修饰的细胞具有降低的免疫原性。
269.一种生成用于移植的修饰的细胞的方法，所述方法包括在培养基中培养修饰的细胞，与相应的野生型细胞相比，所述修饰的细胞具有减少量的主要组织相容性复合物II(MHC II)，其中与相应的野生型细胞相比，修饰的细胞具有降低的免疫原性。
270.一种用于治疗病状的方法，所述方法包括向受试者施用治疗有效量的修饰的细胞，与相应的野生型细胞相比，所述修饰的细胞具有减少量的主要组织相容性复合物II(MHC II)，其中与相应的野生型细胞相比，修饰的细胞具有降低的免疫原性。
271.根据实施方案268-270中任一项所述的修饰的细胞，其中与相应的野生型细胞相比，修饰的细胞具有降低的MHC II的生物合成或运输途径的一种或多种基因的表达。
272.根据实施方案268-270中任一项所述的修饰的细胞，其中与相应的野生型细胞相比，修饰的细胞在修饰的细胞上积累减少量的MHC II。
273.根据实施方案268-270中任一项所述的修饰的细胞，其中修饰的细胞在与MHCII的生物合成或运输途径相关的内源基因中具有破坏。
274.根据实施方案268-270中任一项所述的修饰的细胞，其中破坏包括MHC II类反式激活因子(CIITA)的破坏。
275.根据实施方案268-270中任一项所述的修饰的细胞，其中破坏起因于缺失CIITA中的至少一部分。
276.根据实施方案268-270中任一项所述的修饰的细胞，其中MHC II包括人白细胞抗原II(HLA II)。
277.根据实施方案268-270中任一项所述的修饰的细胞，其中与相应的野生型细胞相比，降低的免疫原性包括由修饰的细胞诱导的炎性反应水平降低。
278.一种修饰的细胞，其与相应的野生型细胞相比包含减少量的主要组织相容性复合物I(MHC I)，其中与相应的野生型细胞相比，修饰的细胞具有降低的免疫原性。
279.根据实施方案278所述的修饰的细胞，其中修饰的细胞在与MHC I的生物合成或运输途径相关的内源基因中具有破坏。
280.根据实施方案279所述的修饰的细胞，其中破坏包括与抗原呈递1(TAP1)基因相关的转运蛋白的一个或多个外显子的破坏或TAP相关糖蛋白(TAPBP)基因的一个或多个外显子的破坏。
281.根据实施方案280所述的修饰的细胞，其中TAP1基因的一个或多个外显子的破坏包括TAP1基因的一个外显子的破坏。
282.根据实施方案280所述的修饰的细胞，其中TAPBP基因的破坏包括TAP1基因的杂合破坏，并且修饰的细胞表达野生型TAPBP基因。
283.根据实施方案280所述的修饰的细胞，其中TAPBP基因的一个或多个外显子的破坏包括TAPBP基因的一个外显子的破坏。
284.根据实施方案280所述的修饰的细胞，其中与相应的野生型细胞相比，降低的免疫原性包括由修饰的细胞诱导的炎性反应水平降低。
285.根据实施方案280所述的修饰的细胞，其中修饰的细胞的核型与相应的野生型细胞的核型相同。
286.根据实施方案280所述的修饰的细胞，其中修饰的细胞的多能性水平与相应的野生型细胞的多能性水平基本上相同。
287.根据实施方案268-286中任一项所述的修饰的细胞，其中细胞是T细胞或NK细胞。
288.根据实施方案268-286中任一项所述的修饰的细胞，其中修饰的细胞包含CAR。
289.根据权利要求288所述的修饰的细胞，其中CAR包含细胞外结构域、跨膜结构域和细胞内结构域，并且细胞外结构域与肿瘤抗原结合。
290.根据实施方案289所述的修饰的细胞，其中肿瘤抗原包括HER2、CD19、CD20、CD22、κ或轻链、CD30、CD33、CD123、CD38、ROR1、ErbB3/4、EGFR、EGFRvIII、EphA2、FAP、癌胚抗原、EGP2、EGP40、间皮素、TAG72、PSMA、NKG2D配体、B7-H6、IL-13受体α2、IL-11受体α、MUC1、MUC16、CA9、GD2、GD3、HMW-MAA、CD171、Lewis Y、G250/CAIX、HLA-AI MAGE A1、HLA-A2NY-ESO-1、PSC1、叶酸受体-α、CD44v7/8、8H9、NCAM、VEGF受体、5T4、胎儿型AchR、NKG2D配体、CD44v6、TEM1或TEM8。
291.根据实施方案289所述的修饰的细胞，其中细胞内结构域包含共刺激结构域，所述共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
292.根据实施方案289所述的修饰的细胞，其中细胞内结构域包含CD3ζ信号传导结构域。
293.一种用于细胞输注的方法，所述方法包括：在培养基中培养根据实施方案246所述的修饰的细胞；以及向受试者施用包含修饰的细胞的组合物，其中响应于输注的受试者免疫应答小于使用野生型细胞的输注。
294.根据实施方案293所述的方法，其中输注是同种异体输注。
295.一种修饰的人T细胞，其包含：编码CAR的核酸序列；TCR基因的破坏；MHC II类反式激活因子(CIITA)基因的破坏；和与抗原呈递1(TAP1)基因相关的转运蛋白的破坏或TAP相关糖蛋白(TAPBP)基因的破坏，其中，与不具有破坏的人T细胞相比，修饰的人T细胞具有减少量的TCR、减少量的MHC I或减少量的MHC II；或与原代人T细胞的宿主抗移植物疾病(HVGD)应答相比，在生物不相容的人受体中的HVGD应答降低。
296.根据实施方案295所述的修饰的细胞，其中CAR包含细胞外结构域、跨膜结构域和细胞内结构域，并且细胞外结构域与肿瘤抗原结合。
297.根据实施方案296所述的修饰的细胞，其中肿瘤抗原包括HER2、CD19、CD20、CD22、κ或轻链、CD30、CD33、CD123、CD38、ROR1、ErbB3/4、EGFR、EGFRvIII、EphA2、FAP、癌胚抗原、EGP2、EGP40、间皮素、TAG72、PSMA、NKG2D配体、B7-H6、IL-13受体α2、IL-11受体α、MUC1、MUC16、CA9、GD2、GD3、HMW-MAA、CD171、Lewis Y、G250/CAIX、HLA-AI MAGE A1、HLA-A2NY-ESO-1、PSC1、叶酸受体-α、CD44v7/8、8H9、NCAM、VEGF受体、5T4、胎儿型AchR、NKG2D配体、CD44v6、TEM1或TEM8。
298.根据实施方案296所述的修饰的细胞，其中细胞内结构域包含共刺激结构域，所述共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
299.根据实施方案296所述的修饰的细胞，其中细胞内结构域包含CD3ζ信号传导结构域。
300.一种修饰淋巴细胞中靶基因组基因座的方法，所述方法包括：将在靶基因组基因座内形成单链或双链断裂的核酸酶剂引入淋巴细胞中；以及选择内源性B2M、CIITA、TAP1和/或TAPBP基因被破坏的淋巴细胞。
301.一种基因修饰的淋巴细胞，其包含靶向内源性B2M、CIITA、TAP1和/或TAPBP基因的核酸酶剂。
302.根据实施方案300-301中任一项所述的方法或基因修饰的淋巴细胞，其中核酸酶剂是锌指核酸酶(ZFN)、类转录激活因子效应子核酸酶(TALEN)或大范围核酸酶。
303.根据实施方案300-301中任一项所述的方法或基因修饰的淋巴细胞，其中核酸酶剂包含成簇的规律性间隔短回文重复序列(CRISPR)相关(Cas)蛋白和指导RNA(gRNA)。
304.根据实施方案303所述的方法，其中Cas蛋白是Cas9。
305.根据实施方案300-301中任一项所述的方法或基因修饰的淋巴细胞，其中核酸酶剂包含列于表9-10中的氨基酸序列中的至少一个。
306.根据实施方案300-301中任一项所述的方法或基因修饰的淋巴细胞，其中核酸酶剂包括：靶向以下的一个或多个ZFN：抗原呈递1(TAP1)基因相关的转运蛋白的一个或多个外显子，或TAP相关糖蛋白(TAPBP)基因的一个或多个外显子的破坏、或TAP1基因的一个外显子；或根据实施方案1-4中任一项所述的分离的ZFN。
307.根据实施方案300-306中任一项所述的基因修饰的淋巴细胞或方法，其中淋巴细胞是NK细胞或T细胞。
308.根据实施方案300-306中任一项所述的基因修饰的淋巴细胞或方法，其中与不包含核酸序列的相应细胞相比，基因修饰的细胞针对同种异体细胞引发减少的移植物抗宿主疾病应答。
309.根据实施方案300-306中任一项所述的基因修饰的淋巴细胞或方法，其中淋巴细胞是衍生自原代人T细胞的T细胞，所述原代人T细胞从人类供体中分离得到。
310.根据实施方案300-306中任一项所述的基因修饰的淋巴细胞或方法，其中T细胞包含CAR。
311.根据实施方案310所述的基因修饰的淋巴细胞或方法，其中CAR包含细胞外结构域、跨膜结构域和细胞内结构域，并且细胞外结构域与肿瘤抗原结合。
312.根据实施方案311所述的基因修饰的淋巴细胞或方法，其中肿瘤抗原包括HER2、CD19、CD20、CD22、κ或轻链、CD30、CD33、CD123、CD38、ROR1、ErbB3/4、EGFR、EGFRvIII、EphA2、FAP、癌胚抗原、EGP2、EGP40、间皮素、TAG72、PSMA、NKG2D配体、B7-H6、IL-13受体α2、IL-11受体α、MUC1、MUC16、CA9、GD2、GD3、HMW-MAA、CD171、Lewis Y、G250/CAIX、HLA-AI MAGEA1、HLA-A2NY-ESO-1、PSC1、叶酸受体-α、CD44v7/8、8H9、NCAM、VEGF受体、5T4、胎儿型AchR、NKG2D配体、CD44v6、TEM1或TEM8。
313.根据实施方案311所述的基因修饰的淋巴细胞或方法，其中细胞内结构域包含共刺激结构域，所述共刺激结构域包括选自以下的共刺激分子的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1(LFA-1)、CD2、CD7、LIGHT、NKG2C、B7-H3及其任何组合。
314.根据实施方案311所述的基因修饰的淋巴细胞或方法，其中细胞内结构域包含CD3ζ信号传导结构域。
315.根据实施方案300-306中任一项所述的基因修饰的淋巴细胞或方法，其中T细胞包含修饰的T细胞受体(TCR)。
316.根据实施方案315所述的基因修饰的淋巴细胞或方法，其中TCR衍生自患者中自发产生的肿瘤特异性T细胞。
317.根据实施方案315所述的基因修饰的淋巴细胞或方法，其中TCR与肿瘤抗原结合。
318.根据实施方案317所述的基因修饰的淋巴细胞或方法，其中肿瘤抗原包括CEA、gp100、MART-1、p53、MAGE-A3或NY-ESO-1。
319.根据实施方案317所述的基因修饰的淋巴细胞或方法，其中TCR包含TCRγ和TCRδ链或TCRα和TCRβ链，或其组合。
320.一种在受试者中引起T细胞应答或治疗受试者肿瘤的方法，所述方法包括：施用有效量的根据实施方案301-319中任一项所述的T细胞。
321.一种确定CAR T细胞疗法的疗效的方法，其中所述方法包括向有需要的受试者施用根据实施方案1-6、14-43、45和46中任一项所述的核酸、细胞、组合物、修饰的T细胞或双特异性CAR，以及在向受试者引入CAR T细胞后的一段时间内测量细胞因子释放的水平。
322.一种监测CAR T细胞疗法的疗效的方法，其中所述方法包括向有需要的受试者施用根据实施方案1-6和14-27中任一项所述的核酸、细胞或组合物，以及在向受试者引入CAR T细胞后的一段时间内测量细胞因子释放的水平。
323.根据实施方案321或322所述的方法，其中所述方法还包括将细胞因子释放的水平与对照受试者进行比较，并且其中对照受试者包括未引入CAR T细胞疗法的受试者或施用包含单个CAR分子(例如，抗实体瘤CAR)的T细胞的受试者。
324.根据实施方案321-323中任一项所述的方法，其中细胞因子是IL-6、IFN-γ或其组合。
325.根据实施方案321-324中任一项所述的方法，其中所述方法包括测量CAR T细胞疗法的第0天(在引入CAR T细胞疗法前的一天)至第10天、至第9天、至第8天、至第7天、至第6天、至第5天、至第4天、至第3天、至第2天、或至第1天的细胞因子释放。
326.根据实施方案321-325中任一项所述的方法，其中受试者患有甲状腺癌、胆管癌、乳癌或胰腺癌。
327.根据实施方案321-326中任一项所述的方法，其中受试者是哺乳动物。
328.根据实施方案321-327中任一项所述的方法，其中哺乳动物是人。
实施例
实施例1.CAR在T细胞上的表达
如图1所示，生成了编码CD19 CAR(CAR：SEQ ID NO.207和scFv：SEQ ID NO.6)和肿瘤相关MUC1 CAR(CAR：SEQ ID NO.202和scFv：SEQ ID NO.70)的慢病毒载体(参见“Chimeric Receptors Containing CD137 Signal Transduction Domains MediateEnhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo,”Molecular Therapy,2009年8月,第17卷第8期,1453–1464，所述参考文件以引用的方式整体并入本文”)。
从患者中获得原代T细胞。用慢病毒载体转导所获得的原代T细胞以获得修饰的T细胞。进行流式细胞术并分析以确定CAR在原代T细胞中的表达(参见图6)。与细胞培养、慢病毒载体构建和流式细胞术相关的技术可在“Control of large,established tumorxenografts with genetically retargeted human T cells containing CD28 andCD137 domains”,PNAS 2009年3月3日，第106卷第9期，3360-3365中找到，所述参考文献以引用的方式整体并入本文。
实施例2.共培养测定中的IFN-γ释放
分别用编码双CAR(CD19 CAR和TA-MUC1 CAR，参见图8和图9中的双CAR)的慢病毒载体和编码单CAR(TA-MUC1 CAR，参见图8和图9中的5E5CAR)的慢病毒载体转染T细胞。共培养两种类型的T细胞和不同的单个类型或多个类型的基底细胞(substrate cell)，并观察IFN-γ的释放。基底细胞包括MUC1阳性肿瘤细胞(MCF-7)、MUC1阴性肿瘤细胞(231)以及CD19阳性肿瘤细胞(RK19)。将E:T(效应细胞:靶细胞)比率为1:1/3:1/10:1/30:1(即，CAR T细胞:靶肿瘤细胞)的CAR T细胞与靶肿瘤细胞共培养24小时。随后，收集上清液，并测量IFN-γ的释放。当共培养CAR T细胞和基底细胞时，观察到各种水平的IFN-γ释放(参见图7)。如图8和图9进一步示出，响应于用CD19阳性肿瘤细胞和MUC1阳性肿瘤细胞的共培养，双CAR T细胞释放IFN-γ，而响应于用CD19阳性肿瘤细胞的共培养，单CAR T细胞释放少量的IFN-γ。此外，响应于用CD19阳性肿瘤细胞和MUC1阳性肿瘤细胞的共培养，双CAR T细胞与单CAR T细胞相比释放更大量的IFN-γ。与细胞培养、细胞毒性T淋巴细胞测定构建相关的技术可在“Control of large,established tumor xenografts with geneticallyretargeted human T cells containing CD28 and CD137 domains”,PNAS 2009年3月3日，第106卷第9期，3360-3365中找到，所述参考文献以引用的方式整体并入本文。
实施例3.CAR/抗原在原代T细胞上的表达
从患者中获得原代T细胞。将所获得的原代T细胞分为两组。用包含编码抗TSHRCAR的核酸序列(SEQ ID:8)的慢病毒载体转导第1组中的原代T细胞。用包含编码TSHR的核酸序列(SEQ ID:20)的慢病毒载体转导第2组中的原代T细胞。进行流式细胞术并分析以分别确定CAR和TSHR在原代T细胞中的表达(图8和图9)。与细胞培养、慢病毒载体构建和流式细胞术相关的技术可在“Control of large,established tumor xenografts withgenetically retargeted human T cells containing CD28 and CD137 domains”,PNAS2009年3月3日，第106卷第9期，3360-3365中找到，所述参考文献以引用的方式整体并入本文。
实施例4.体内细胞因子释放测定
将第1组和第2组的原代T细胞注入小鼠中(实验组)。作为对照，将单独第1组的原代T细胞或缓冲液输注到小鼠中(第1对照组和第2对照组)。下表1提供了关于细胞输注的几个参数。辐照NPGTM(NOD Prkdcscid IL2rgnull)小鼠，并将一定数量的CAR T细胞和相应的对照剂输注到小鼠中。对于第2对照组，将缓冲液连续返回给小鼠三次。对于第1对照组，不表达抗原的T细胞连续返回三次。对于实验组，表达抗原的T细胞连续输注三次。输注完成之后，收集来自角膜缘静脉的血液以分析小鼠外周血中的T细胞和因子释放(例如，细胞因子释放)。然后处死小鼠，并收集每个器官的T比率/CAR T细胞比率/CAR T拷贝和其他数据。然后进行细胞因子释放测定。对于实验组和对照组，测量了小鼠外周血中的各种细胞因子(例如，IFN-γ、IL4、IL2)。如图10-13所示，实验组中释放的细胞因子的量大于对照组。这些结果表明，输注表达抗原的细胞可增强相应的CAR T细胞的T细胞应答。表2概述了将T细胞输注到小鼠中，表3提供了体内分析细胞因子释放的时间表。
表2
表3
下表(表4)示出了各种多肽结构域和核酸构建体及其序列标识符(SEQ ID NO)。(CD19是指CD19 CAR；MUC1是指tMUC1 CAR；A、B、C和D是指相应CAR的铰链和/或跨膜结构域的具体序列)
表4
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实施例5.体内细胞扩增
这些临床研究目的在于评定将经过修饰以表达几种实体瘤标志物特异性CAR/4-1BB/CD3-ζ的自体T细胞输注到患者中的安全性和疗效。在研究的第一组(arm)中，患者仅接受实体瘤标志物特异性CAR T细胞。实体瘤标志物包括TSHR和tMuc1。在第二组中，患者接受针对CD19和tMuc1的CAR T细胞。获得患者的T细胞，对其进行修饰并输注至患者。测量来自第一组和第二组的患者的T细胞应答并使用以下方案进行比较，所述方案由进行试验的医院批准。给所有患者提供书面知情同意书。
通过用TSHR-4-1BB载体、tMuc1-4-1BB载体、CARtMuc1/CAR19-4-1BB载体和病毒包装质粒转染293T细胞来产生慢病毒，所述载体和质粒在-80℃下冷冻，在转导前立即融化。收获慢病毒上清液。如所描述，分离和激活CD3+T细胞(参见Kalos M.等人,Sci Transl Med2011；3:95ra73)。然后在含有100U/ml白细胞介素-2(IL-2)的X-VIVO 15培养基(Lonza)中培养CD3+T细胞，并在24-48小时内以5:1至10:1的高感染复数(MOI)用慢病毒上清液转导。将CAR转导的T细胞(TSHR-CAR T细胞、tMuc1-CAR T细胞或tMuc1-CAR/CD19-CAR T细胞，下文称为“双CAR T细胞”)培养约11天。在施用前的三天，更换新鲜的培养基。此后，直到运输输注才操控细胞。在慢病毒转导后的第5-7天，通过流式细胞术(FACS)评估转导效率。使用了以下抗人类抗体：抗hCD45APC(BD Bioscience)、抗hCD3FITC(BDBioscience)、特异于F(ab’)2片段的生物素标记的山羊抗小鼠IgG(Jackson immuno-Research,Cat#115-065-072)和PE链霉亲和素(BD Bioscience)。使用CytoFLEX流式细胞仪(Beckman)进行数据获取。
如本实施例以及实施例1和2中所述，对每位患者进行CAR T细胞的转导效率和体外细胞毒性测定的FACS分析。另外，对CAR T细胞培养物进行两次真菌、细菌、支原体、衣原体和内毒素污染检查。
在第8天通过白细胞单采从患者中获得外周血单核细胞(PBMC)以制备CAR T细胞，并将CAR T输注的第一天设为研究的第0天。给予患者淋巴切除的调理治疗(conditioningtreatment)。基于氟达拉滨和环磷酰胺的调理治疗会根据骨髓(BM)和外周血(PB)中的肿瘤负荷而变化。将CAR T细胞输给患者。每天将CAR T细胞运输到医院，洗涤，计数，检查生存力，然后准备向患者施用，然后密切观察患者至少2小时。根据修订的分级系统对CRS进行分级(参见Lee DW.等人,Blood 2014；124:188-95)。根据美国国立卫生研究院不良事件通用术语标准4.0版(http://ctep.cancer.gov/)评定治疗期间和治疗后的其他毒性。通过流式细胞术和形态分析评定治疗响应。当可能时，通过嵌合基因表达水平评定患者。响应类型被定义为微小残留病(MRD)阴性、完全响应、计数不完全恢复的完全响应、稳定疾病和进行性疾病。
将CAR T细胞输注后的一系列BM和PB样品收集在K2EDTA BD采血管(BD)中。通过FACS确定来自患者新鲜PB和BM的CAR19T细胞持久性。基于所测量的绝对CD3+T淋巴细胞计数，计算每微升的循环CAR T细胞数。同时，CAR DNA拷贝被评估为确定CAR T细胞扩增和持久性的另一种方法。使用QIAamp DNA血液微型试剂盒(Qiagen)，从冷冻保存的PB和BM中提取基因组DNA。如补充材料中所述，通过定量实时PCR评定CAR DNA拷贝。根据制造商的说明书，以多重形式测量血清和CSF中的细胞因子IFN-γ、TNF-α、IL-4、IL-6、IL-10、IL-17等的水平。
使用QIAamp DNA血液微型试剂盒(Qiagen)，从冷冻保存的外周血和骨髓中提取基因组DNA。在7500实时PCR系统(Applied Biosystems)中使用ABI 2×TaqMan UniversalMaster Mix与AmpErase UNG(Applied Biosystems)一式三份实时进行定量PCR(qPCR)。从含有102-108个拷贝/微升的纯化CAR质粒的10倍系列稀释液的标准曲线中计算每微克基因组DNA的拷贝数。内参基因的扩增用于标准化DNA量。特异于CAR19转基因和内参基因的引物/探针如先前所述(参见N.等人,Blood 2012；120:2032-41和O'Brien S.等人,JClin Oncol 2013；31:676-83)。
这些患者的CAR T细胞扩增和细胞因子释放如图16-20和图49-52所示。这些结果表明，与仅表达肿瘤标志物特异性CAR的T细胞相比，表达CD19 CAR和肿瘤标志物特异性CAR的T细胞扩增更多，并且释放更多的细胞因子(例如，IL-6和IFN-γ)。关于患者及其相应的T细胞的信息提供在下表5中。
表5
图51-52示出与仅施用一个CAR的患者C相比，施用第一CAR和第二CAR的患者F中细胞因子IL-6和IFN-γ的释放升高。细胞因子IL-6和IFN-γ的释放升高证实了使用第一CAR和第二CAR分子(每个CAR分子结合不同的抗原)的CAR T细胞疗法的疗效。
实施例6.ZFN的设计I
构建多种基因特异性ZFN以使得能够在这些基因处位点特异性引入突变。基本上如Mala等人(2005)Biochem Biophys Res Commun 335(2):447-57，Liu等人(2002)J BioChem 277(6):3850-6，Sander等人(2011)Nat Methods.8(1):67-9，Urnov等人(2005)Nature 435(7042):646-651和美国专利公布2008/0131962所述，设计各种ZFN并将其并入质粒载体中。ZFN包括锌指结合结构域(例如ZFN左和ZFN右结合域)的各种组合，这些组合列于表6和表7中。ZFN的切割结构域包含工程化的FokI切割结构域(SEQ ID NOS.:280、281或282)。
表6：示例性ZFN对以及靶序列(靶位点：ZFN的靶序列包含由6个碱基对的间隔隔开的两个9个碱基对的识别位点(即大写字母))
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实施例7.体外ZFN活性I
使用fugene转染试剂分别将ZFN左臂质粒载体和ZFN右臂质粒载体转染到Hela细胞中。转染24小时后，用1μg/ml嘌呤霉素处理Hela细胞48小时，以获得富含ZFN的细胞。然后收集Hela细胞，并且使用特异于各种基因(即CTLA4、LAG3、BTLA、TIM3、FOXP3、SIVA1、或LGALS9)的引物和作为模板的Hela细胞基因组，通过PCR扩增含有ZFN的裂解的DNA片段。使用正向引物对DNA片段进行测序，并且测序结果示于图21-25中。
将DNA片段克隆到载体中。对具有约30个单克隆细胞的DNA片段进行测序以确定DNA片段是否包含突变。测序的结果示于表7中。
表7：靶向基因片段并通过PCR扩增的ZFN的单克隆测序结果
实施例8.ZFN的设计II
构建多种基因特异性ZFN以使得能够在这些基因中位点特异性引入突变。基本上如Mala等人(2005)Biochem Biophys Res Commun 335(2):447-57，Liu等人(2002)J BioChem 277(6):3850-6，Sander等人(2011)Nat Methods.8(1):67-9，Handel等人(2009)MolTher.Jan；17(1):104-11，Urnov等人(2005)Nature 435(7042):646-651和美国专利公布2008/0131962所述，设计各种ZFN并将其并入质粒载体中。ZFN包括锌指结合结构域(例如ZFN左和ZFN右结合域)的各种组合，这些组合列于表8中。ZFN的切割结构域包含工程化的FokI切割结构域(SEQ ID NOS.:96、97或98)。
表8：示例性ZFN对以及靶序列(靶位点：ZFN的靶序列包含由6个碱基对的间隔隔开的两个9个碱基对的识别位点(即大写字母))
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实施例9.体外ZFN活性II
使用fugene转染试剂分别将ZFN左臂质粒载体和ZFN右臂质粒载体转染到Hela细胞中。转染24小时后，用1μg/ml嘌呤霉素处理Hela细胞48小时，以获得富含ZFN的细胞。然后收集Hela细胞，并且使用特异于各种基因(即B2M和CIITA)的引物和作为模板的Hela细胞基因组，通过PCR扩增含有ZFN的裂解的DNA片段。使用正向引物对DNA片段进行测序，并且测序结果示于图27-30中。
将DNA片段克隆到载体中。对具有约30个单克隆细胞的DNA片段进行测序以确定DNA片段是否包含突变。测序的结果示于表10中。
实施例10.ZFN的设计III
使T细胞引入具有TRAC特异性ZFN，所述TRAC特异性ZFN被构建以使得能够在TRAC基因处位点特异性引入突变。基本上如Urnov等人(2005)Nature 435(7042):646-651，Lombardo等人(2007)Nat Biotechnol.November；25(11):1298-306和美国专利公布2008/0131962所述，设计各种ZFN并将其并入质粒载体中。ZFN包括锌指结合结构域(例如ZFN左和ZFN右结合域)的各种组合，这些组合列于表9中。ZFN的切割结构域包含FokI切割结构域(SEQ ID NOS.:96、97或98)。将编码一对ZFN的mRNA(参见表9)引入转导的细胞中，以修饰与TCR的α链相关的靶基因组基因座。
表9
实施例11.TALEN效率检测
针对CIITA的TALEN目的在于靶向外显子2(2L1：gctgaccccctgtgcct(SEQ ID NO:426)；2L2：gaccccctgtgcctct(SEQ ID NO:427)；2R1：ctccagccaggtccatct(SEQ ID NO:419)；2R2：tctccagccaggtccat(SEQ ID NO:420))和外显子3(3L1：tcagcaggctgttgt(SEQID NO:421)；3L2：tcagcaggctgttgtgt(SEQ ID NO:422)；3R1：ccctggtctcttcat(SEQ IDNO:423)；3R2：aagcctccctggtctt(SEQ ID NO:424)；3R3：aagcctccctggtct(SEQ ID NO:425))。如前所述，用FastTALE TALEN组装试剂盒(Sidansai)构建TALEN，并且其活性在293T细胞中得到证实。将构建的TALEN转染到293T细胞中并且用2μg/ml嘌呤霉素(Sigma)选择。选择后收获293T细胞的基因组DNA。然后，进行PCR和测序以检验TALEN的效率。
表10：靶向各种基因片段并通过PCR扩增的ZFN的单克隆测序结果
实施例12.Cas9设计和分析
使用fugene转染试剂，将表达Cas9和gRNA的质粒共转染到293T细胞中。72小时后，收集293T细胞，并且通过流式细胞术检测B2m和HLA蛋白的表达(图31)。
实施例13.MCF-7和双CAR再输注I
使用8只NPG雌性小鼠，这些小鼠为6周龄。在第0天，用350w MCF-7细胞对每只小鼠进行接种以建立原位肿瘤模型。在第35天，用如表11所示的相应细胞输注每只小鼠。
表11：实验方案
在第42天，从眼眶静脉丛收集每只小鼠约150ul的血液。在第49天，从眼眶静脉丛收集小鼠的小鼠血液，每只小鼠约150ul。对每种外周血进行离心以分离血浆，并且血浆用于测量细胞因子。进行破红细胞处理(red-breaking treatment)后，用抗体染色外周血沉淀的细胞，然后进行流式细胞术。
测量小鼠外周血中T细胞/小鼠白细胞的百分数。结果提供于图32-39和表12中。
图32-35示出了不同组中人白细胞/鼠白细胞的流式细胞术检测结果。小鼠外周血裂解后，这些细胞衍生自所有活细胞。横轴代表hCD45的相应染色的荧光强度，并且纵轴代表mCD45的相应染色的荧光强度。
图36-39示出了T细胞/人白细胞的流式细胞术检测结果。这些细胞衍生自图32-35中的人白细胞hCD45，横轴代表CD3的相应染色的荧光强度，并且纵轴代表CD19的相应染色的荧光强度。
表12：白细胞/鼠白细胞％
如上所示，模拟组中的T细胞(N/A输注细胞)比例为0％，而NT组中的T细胞较少，这符合预期。2407组中的T细胞比例高于1204+2407组，但由于小鼠数量少，还需要进一步实验。因此，双CAR细胞可像单CAR细胞一样激活。
图40示出了每只小鼠的细胞因子IL-2和IFN-γ的释放。从小鼠获得外周血样品，并且上清液提供在如下表13中(单位：pg/mL)。
表13：细胞因子数据
如上所示，IL-2:2407和1204+2407的IL-2释放水平略高于NT和模拟(N/A输注细胞)。NT组和模拟组中的IFN-γ基本上为0，并且1204+2407组中的IFN-γ释放远高于2407组。因此，双CAR细胞可像单CAR细胞一样释放细胞因子。
图41-44示出了小鼠外周血T细胞中的CD8/CD4比例。这些细胞衍生自图36-39中的CD3阳性细胞，并且横轴代表CD4的相应染色的荧光强度，纵轴代表CD8的相应染色的荧光强度。具体结果提供在表14中。
表14：T细胞中的CD8/CD4
如上所示，模拟组(N/A输注细胞)不具有CD8和CD4。2407组和1204+2407组基本上持平，并且NT组CD8/CD4比率远高于这两个组。
实施例14.MCF-7和双CAR再输注II
使用17只NPG雌性小鼠，这些小鼠为8周龄。在动物到达后，对它们进行消毒并转移至动物室。使实验动物适应新环境7天。在适应期间，每天在笼子中观察动物。在动物适应期结束后，在实验建模的前一天对动物进行辐照。辐照剂量为1Gy。
在辐照后的第二天对小鼠进行建模。通过用乳腺脂肪垫原位接种，将MCF-7细胞注射到小鼠的乳腺脂肪垫中以建立肿瘤模型。建模之日为第0天。
表15：小鼠建模方案
动物数/性别 建模细胞 建模方法 建模细胞质量
17/F MCF-7 乳房脂肪垫原位接种 500w/小鼠
根据如表16所示的随机分组，将建模的17只小鼠分成4组。
表16：实验方案
建模后，当肉眼可见明显肿瘤时，开始对小鼠肿瘤进行体积测量。如下进行Nalm6细胞刺激。在第9天，用Nalm6细胞注射2407+1204(Naml6刺激)组中的五只小鼠用于刺激。使用表17中的方案，通过尾静脉注射将Nalm6细胞注射到小鼠中。
表17：实验方案
刺激细胞 刺激细胞质量
Nalm6 50w/小鼠
在第10天，用如表18所示的相应细胞输注每只小鼠(尾静脉注射)。
表18：实验方案
在细胞再输注一周后，对小鼠进行外周血收集，并且通过眼眶静脉丛收集血液。在第17天，进行第一次血液收集。
对外周血进行离心以分离血浆，并且血浆用于测量细胞因子。进行破红细胞处理后，用抗体染色外周血沉淀的细胞，然后进行流式细胞术。分析数据并示于图45-47(外周血流数据)中。
图45示出了T细胞/小鼠白细胞的结果。从表19中的统计和数据可以看出，NT组、2407组和Nalm6+2407+1204组的T细胞/小鼠中的白细胞比率相似，而2407+1204组的T细胞/小鼠中的白细胞比率高于其他四组。
表19：T细胞/小鼠白细胞
图46示出了CD8/CD4的结果。从表20中的统计数据可以看出，四组CD8/CD4的比率没有显著差异。
表20：CD8/CD4的比率
分析了来自小鼠和上清液的外周血样品(单位：pg/mL)和细胞因子数据(表21)并示于图47中。从统计图和表格数据可以看出，2407组中的IL-2释放高于其他三组。此外，从统计和表格数据可以看出，2407组中的IFN释放显著高于其他三组。2407+1204组和Nalm6+2407+1204组中释放的IFN量相对接近。
表21：细胞因子数据
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图48示出了响应于用不同细胞输注的组，小鼠的肿瘤体积变化。在输注各种细胞后，在特定时间段里测量不同小鼠中的肿瘤体积(单位，mm3，根据以下的体积公式V＝长径*短径*短径*0.5)。结果如图48所示。从上图可以看出，再输注后，2407+1204组的肿瘤体积基本上保持不变，而Nalm6+2407+1204组和2407组中的肿瘤体积减小，NT组的肿瘤体积增加。因此，双CAR和单CAR具有相似的抗肿瘤功能。
本说明书中引用的所有出版物、专利和专利申请均以引用的方式整体并入本文，就好像每个单独的出版物、专利或专利申请被明确地并单独地指示以引用的方式并入。尽管已根据各种实施方案描述了前述内容，但是本领域技术人员将理解，可以在不脱离其精神的情况下进行各种修改、替换、省略和改变。
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<120> 修饰细胞的扩增及其用途
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210 215 220
Ala Arg His Arg Gly Asn Tyr Tyr Ala Thr Tyr Tyr Tyr Ala Met Asp
225 230 235 240
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
245 250
<210> 10
<211> 243
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 10
Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly
1 5 10 15
Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr
20 25 30
Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile
35 40 45
Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65 70 75 80
Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His His Glu Tyr Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
115 120 125
Pro Gly Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys
130 135 140
Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Trp Met Asn Trp Val Lys
145 150 155 160
Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr
165 170 175
Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu
180 185 190
Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu
195 200 205
Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Pro Tyr Tyr
210 215 220
Gly Thr Asn Pro Trp Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr
225 230 235 240
Val Ser Ser
<210> 11
<211> 241
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 11
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser
65 70 75 80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg
85 90 95
Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln
115 120 125
Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys
130 135 140
Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg
145 150 155 160
Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg
165 170 175
Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser
180 185 190
Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr
195 200 205
Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr
210 215 220
Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
225 230 235 240
Ser
<210> 12
<211> 246
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 12
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Arg Leu Gly
1 5 10 15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser
85 90 95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly
130 135 140
Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp
145 150 155 160
Tyr Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp
165 170 175
Ile Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn
180 185 190
Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala
195 200 205
Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe
210 215 220
Cys Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr
225 230 235 240
Leu Val Thr Val Ser Ala
245
<210> 13
<211> 199
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 13
Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg
1 5 10 15
Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu
20 25 30
Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg
35 40 45
Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala
50 55 60
Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe
65 70 75 80
Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr
85 90 95
His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile
100 105 110
Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu
115 120 125
Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn
130 135 140
Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp
145 150 155 160
Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg
165 170 175
Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg
180 185 190
Ile Ile His Asn Asn Asn Cys
195
<210> 14
<211> 240
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 14
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln
85 90 95
Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
130 135 140
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
145 150 155 160
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
165 170 175
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
180 185 190
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
195 200 205
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln
210 215 220
Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
225 230 235 240
<210> 15
<211> 281
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 15
Met Asn Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Thr
1 5 10 15
Gly Gly Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser
20 25 30
Ala Ser Leu Glu Glu Ile Val Thr Ile Thr Cys Lys Ala Ser Gln Ala
35 40 45
Ile Asp Ala Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro
50 55 60
Gln Leu Leu Ile Tyr Asp Ala Thr Ser Leu Ala Asp Gly Val Pro Ser
65 70 75 80
Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser
85 90 95
Arg Pro Gln Val Asp Asp Ser Gly Ile Tyr Tyr Cys Leu Gln Ser Tyr
100 105 110
Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met
130 135 140
Ala Val Leu Val Leu Leu Leu Cys Leu Leu Ile Phe Pro Ser Cys Val
145 150 155 160
Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro
165 170 175
Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Leu Thr
180 185 190
Ser Asn Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
195 200 205
Trp Met Gly Val Ile Trp Ser Asn Gly Asp Ala Asp Tyr Asn Ser Ala
210 215 220
Ile Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val
225 230 235 240
Phe Leu Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe
245 250 255
Cys Ala Ser Pro Tyr Tyr Gly Tyr Tyr Phe Pro Phe Asp Tyr Trp Gly
260 265 270
Gln Gly Val Met Val Thr Val Ser Ser
275 280
<210> 16
<211> 285
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
1 5 10 15
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val
20 25 30
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val
35 40 45
Ser Ile Ser Ser His Asp Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly
50 55 60
Gln Gln Pro Lys Leu Leu Ile Tyr Asp Ala Phe Asn Leu Ala Ser Gly
65 70 75 80
Ile Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
85 90 95
Thr Ile Asp Pro Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln
100 105 110
Gln Ser Lys Asp Asp Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu
115 120 125
Leu Lys Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
130 135 140
Gly Ser Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile
145 150 155 160
Lys Gly Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
165 170 175
Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe
180 185 190
Thr Phe Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys
195 200 205
Gly Leu Glu Trp Val Ala Thr Ile Ser Tyr Asp Gly Ser Ile Thr Tyr
210 215 220
Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala
225 230 235 240
Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr
245 250 255
Ala Thr Tyr Tyr Cys Thr Arg Glu Glu Gln Tyr Ser Ser Trp Tyr Phe
260 265 270
Asp Phe Trp Gly Pro Gly Ile Met Val Thr Val Ser Ser
275 280 285
<210> 17
<211> 242
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 17
Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Tyr Asn Ser Tyr Asn Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys Glu
115 120 125
Ser Gly Pro Val Leu Val Lys Pro Thr Glu Thr Leu Thr Leu Thr Cys
130 135 140
Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp
145 150 155 160
Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile Trp
165 170 175
Trp Asp Asp Asp Val Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr
180 185 190
Ile Thr Lys Asp Ala Ser Lys Asp Gln Val Ser Leu Lys Leu Ser Ser
195 200 205
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val Arg Arg Arg Ala
210 215 220
Thr Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
225 230 235 240
Ser Ser
<210> 18
<211> 272
<212> PRT
<213> 智人（Homo sapiens）
<400> 18
Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val
1 5 10 15
Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr
20 25 30
Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly
35 40 45
Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe
50 55 60
Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro
65 70 75 80
Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val
85 90 95
Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly
100 105 110
Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro
115 120 125
Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg
130 135 140
Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser
145 150 155 160
Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr
165 170 175
Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro
180 185 190
Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser
195 200 205
Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu
210 215 220
Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr
225 230 235 240
Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr
245 250 255
Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys
260 265 270
<210> 19
<211> 205
<212> PRT
<213> 智人（Homo sapiens）
<400> 19
Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly Lys Cys Gln Pro
1 5 10 15
Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn Met Thr Arg Met
20 25 30
Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala Ala Ile Gln Leu
35 40 45
His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His Gly His Leu Arg
50 55 60
Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr Glu Gln Val Ser
65 70 75 80
Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln Ala Arg Leu Lys
85 90 95
Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp Pro Asp Ser Leu
100 105 110
Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn Tyr Leu Cys Met
115 120 125
Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg Gly Ser Gly Leu
130 135 140
Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser Ala Gln Glu His
145 150 155 160
Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys Asp Asn Pro Gly
165 170 175
Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala Pro Leu Cys Thr
180 185 190
Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys Arg
195 200 205
<210> 20
<211> 393
<212> PRT
<213> 智人（Homo sapiens）
<400> 20
Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His Gln Glu Glu Asp
1 5 10 15
Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro Ser Leu Pro Pro
20 25 30
Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu Arg Thr Ile Pro
35 40 45
Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser
50 55 60
Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu
65 70 75 80
Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg Asn Leu Thr Tyr
85 90 95
Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly
100 105 110
Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr
115 120 125
Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met
130 135 140
Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys Asn Glu Thr Leu
145 150 155 160
Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala
165 170 175
Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr
180 185 190
Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val Tyr Ser Gly Pro
195 200 205
Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala Leu Pro Ser Lys
210 215 220
Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn Thr Trp Thr Leu
225 230 235 240
Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu Thr Arg Ala Asp
245 250 255
Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn Gln Lys Lys Ile
260 265 270
Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser Ser Met Gln Ser
275 280 285
Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser Pro Leu His Gln
290 295 300
Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly Tyr Lys Glu Lys
305 310 315 320
Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr Tyr Val Phe Phe
325 330 335
Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln Glu Leu Lys Asn
340 345 350
Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His Tyr Asp Tyr Thr
355 360 365
Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro Lys Ser Asp Glu
370 375 380
Phe Asn Pro Cys Glu Asp Ile Met Gly
385 390
<210> 21
<211> 210
<212> PRT
<213> 智人（Homo sapiens）
<400> 21
Gln Leu Pro Pro Gly Lys Pro Glu Ile Phe Lys Cys Arg Ser Pro Asn
1 5 10 15
Lys Glu Thr Phe Thr Cys Trp Trp Arg Pro Gly Thr Asp Gly Gly Leu
20 25 30
Pro Thr Asn Tyr Ser Leu Thr Tyr His Arg Glu Gly Glu Thr Leu Met
35 40 45
His Glu Cys Pro Asp Tyr Ile Thr Gly Gly Pro Asn Ser Cys His Phe
50 55 60
Gly Lys Gln Tyr Thr Ser Met Trp Arg Thr Tyr Ile Met Met Val Asn
65 70 75 80
Ala Thr Asn Gln Met Gly Ser Ser Phe Ser Asp Glu Leu Tyr Val Asp
85 90 95
Val Thr Tyr Ile Val Gln Pro Asp Pro Pro Leu Glu Leu Ala Val Glu
100 105 110
Val Lys Gln Pro Glu Asp Arg Lys Pro Tyr Leu Trp Ile Lys Trp Ser
115 120 125
Pro Pro Thr Leu Ile Asp Leu Lys Thr Gly Trp Phe Thr Leu Leu Tyr
130 135 140
Glu Ile Arg Leu Lys Pro Glu Lys Ala Ala Glu Trp Glu Ile His Phe
145 150 155 160
Ala Gly Gln Gln Thr Glu Phe Lys Ile Leu Ser Leu His Pro Gly Gln
165 170 175
Lys Tyr Leu Val Gln Val Arg Cys Lys Pro Asp His Gly Tyr Trp Ser
180 185 190
Ala Trp Ser Pro Ala Thr Phe Ile Gln Ile Pro Ser Asp Phe Thr Met
195 200 205
Asn Asp
210
<210> 22
<211> 4368
<212> PRT
<213> 智人（Homo sapiens）
<400> 22
Glu Gln Asp Leu Ser Val Asn Arg Ala Val Trp Asp Gly Gly Gly Cys
1 5 10 15
Ile Ser Gln Gly Asp Val Leu Asn Arg Gln Cys Gln Gln Leu Ser Gln
20 25 30
His Val Arg Thr Gly Ser Ala Ala Asn Thr Ala Thr Gly Thr Thr Ser
35 40 45
Thr Asn Val Val Glu Pro Arg Met Tyr Leu Ser Cys Ser Thr Asn Pro
50 55 60
Glu Met Thr Ser Ile Glu Ser Ser Val Thr Ser Asp Thr Pro Gly Val
65 70 75 80
Ser Ser Thr Arg Met Thr Pro Thr Glu Ser Arg Thr Thr Ser Glu Ser
85 90 95
Thr Ser Asp Ser Thr Thr Leu Phe Pro Ser Ser Thr Glu Asp Thr Ser
100 105 110
Ser Pro Thr Thr Pro Glu Gly Thr Asp Val Pro Met Ser Thr Pro Ser
115 120 125
Glu Glu Ser Ile Ser Ser Thr Met Ala Phe Val Ser Thr Ala Pro Leu
130 135 140
Pro Ser Phe Glu Ala Tyr Thr Ser Leu Thr Tyr Lys Val Asp Met Ser
145 150 155 160
Thr Pro Leu Thr Thr Ser Thr Gln Ala Ser Ser Ser Pro Thr Thr Pro
165 170 175
Glu Ser Thr Thr Ile Pro Lys Ser Thr Asn Ser Glu Gly Ser Thr Pro
180 185 190
Leu Thr Ser Met Pro Ala Ser Thr Met Lys Val Ala Ser Ser Glu Ala
195 200 205
Ile Thr Leu Leu Thr Thr Pro Val Glu Ile Ser Thr Pro Val Thr Ile
210 215 220
Ser Ala Gln Ala Ser Ser Ser Pro Thr Thr Ala Glu Gly Pro Ser Leu
225 230 235 240
Ser Asn Ser Ala Pro Ser Gly Gly Ser Thr Pro Leu Thr Arg Met Pro
245 250 255
Leu Ser Val Met Leu Val Val Ser Ser Glu Ala Ser Thr Leu Ser Thr
260 265 270
Thr Pro Ala Ala Thr Asn Ile Pro Val Ile Thr Ser Thr Glu Ala Ser
275 280 285
Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Ile Pro Thr Ser Thr Tyr
290 295 300
Thr Glu Gly Ser Thr Pro Leu Thr Ser Thr Pro Ala Ser Thr Met Pro
305 310 315 320
Val Ala Thr Ser Glu Met Ser Thr Leu Ser Ile Thr Pro Val Asp Thr
325 330 335
Ser Thr Leu Val Thr Thr Ser Thr Glu Pro Ser Ser Leu Pro Thr Thr
340 345 350
Ala Glu Ala Thr Ser Met Leu Thr Ser Thr Leu Ser Glu Gly Ser Thr
355 360 365
Pro Leu Thr Asn Met Pro Val Ser Thr Ile Leu Val Ala Ser Ser Glu
370 375 380
Ala Ser Thr Thr Ser Thr Ile Pro Val Asp Ser Lys Thr Phe Val Thr
385 390 395 400
Thr Ala Ser Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu Asp Thr Ser
405 410 415
Ile Ala Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met
420 425 430
Pro Val Ser Thr Thr Pro Val Ala Ser Ser Glu Ala Ser Asn Leu Ser
435 440 445
Thr Thr Pro Val Asp Ser Lys Thr Gln Val Thr Thr Ser Thr Glu Ala
450 455 460
Ser Ser Ser Pro Pro Thr Ala Glu Val Asn Ser Met Pro Thr Ser Thr
465 470 475 480
Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Ser Val Ser Thr Met
485 490 495
Pro Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp
500 505 510
Thr Ser Thr Pro Val Thr Thr Ser Ser Glu Ala Ser Ser Ser Ser Thr
515 520 525
Thr Pro Glu Gly Thr Ser Ile Pro Thr Ser Thr Pro Ser Glu Gly Ser
530 535 540
Thr Pro Leu Thr Asn Met Pro Val Ser Thr Arg Leu Val Val Ser Ser
545 550 555 560
Glu Ala Ser Thr Thr Ser Thr Thr Pro Ala Asp Ser Asn Thr Phe Val
565 570 575
Thr Thr Ser Ser Glu Ala Ser Ser Ser Ser Thr Thr Ala Glu Gly Thr
580 585 590
Ser Met Pro Thr Ser Thr Tyr Ser Glu Arg Gly Thr Thr Ile Thr Ser
595 600 605
Met Ser Val Ser Thr Thr Leu Val Ala Ser Ser Glu Ala Ser Thr Leu
610 615 620
Ser Thr Thr Pro Val Asp Ser Asn Thr Pro Val Thr Thr Ser Thr Glu
625 630 635 640
Ala Thr Ser Ser Ser Thr Thr Ala Glu Gly Thr Ser Met Pro Thr Ser
645 650 655
Thr Tyr Thr Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Val Asn Thr
660 665 670
Thr Leu Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val
675 680 685
Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro
690 695 700
Thr Thr Ala Asp Gly Ala Ser Met Pro Thr Ser Thr Pro Ser Glu Gly
705 710 715 720
Ser Thr Pro Leu Thr Ser Met Pro Val Ser Lys Thr Leu Leu Thr Ser
725 730 735
Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Leu Asp Thr Ser Thr His
740 745 750
Ile Thr Thr Ser Thr Glu Ala Ser Cys Ser Pro Thr Thr Thr Glu Gly
755 760 765
Thr Ser Met Pro Ile Ser Thr Pro Ser Glu Gly Ser Pro Leu Leu Thr
770 775 780
Ser Ile Pro Val Ser Ile Thr Pro Val Thr Ser Pro Glu Ala Ser Thr
785 790 795 800
Leu Ser Thr Thr Pro Val Asp Ser Asn Ser Pro Val Thr Thr Ser Thr
805 810 815
Glu Val Ser Ser Ser Pro Thr Pro Ala Glu Gly Thr Ser Met Pro Thr
820 825 830
Ser Thr Tyr Ser Glu Gly Arg Thr Pro Leu Thr Ser Met Pro Val Ser
835 840 845
Thr Thr Leu Val Ala Thr Ser Ala Ile Ser Thr Leu Ser Thr Thr Pro
850 855 860
Val Asp Thr Ser Thr Pro Val Thr Asn Ser Thr Glu Ala Arg Ser Ser
865 870 875 880
Pro Thr Thr Ser Glu Gly Thr Ser Met Pro Thr Ser Thr Pro Gly Glu
885 890 895
Gly Ser Thr Pro Leu Thr Ser Met Pro Asp Ser Thr Thr Pro Val Val
900 905 910
Ser Ser Glu Ala Arg Thr Leu Ser Ala Thr Pro Val Asp Thr Ser Thr
915 920 925
Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Pro Thr Thr Ala Glu
930 935 940
Gly Thr Ser Ile Pro Thr Ser Thr Pro Ser Glu Gly Thr Thr Pro Leu
945 950 955 960
Thr Ser Thr Pro Val Ser His Thr Leu Val Ala Asn Ser Glu Ala Ser
965 970 975
Thr Leu Ser Thr Thr Pro Val Asp Ser Asn Thr Pro Leu Thr Thr Ser
980 985 990
Thr Glu Ala Ser Ser Pro Pro Pro Thr Ala Glu Gly Thr Ser Met Pro
995 1000 1005
Thr Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Arg Met Pro Val
1010 1015 1020
Ser Thr Thr Met Val Ala Ser Ser Glu Thr Ser Thr Leu Ser Thr Thr
1025 1030 1035 1040
Pro Ala Asp Thr Ser Thr Pro Val Thr Thr Tyr Ser Gln Ala Ser Ser
1045 1050 1055
Ser Ser Thr Thr Ala Asp Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser
1060 1065 1070
Glu Gly Ser Thr Pro Leu Thr Ser Val Pro Val Ser Thr Arg Leu Val
1075 1080 1085
Val Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser
1090 1095 1100
Ile Pro Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala
1105 1110 1115 1120
Glu Gly Thr Ser Ile Pro Thr Ser Pro Pro Ser Glu Gly Thr Thr Pro
1125 1130 1135
Leu Ala Ser Met Pro Val Ser Thr Thr Leu Val Val Ser Ser Glu Ala
1140 1145 1150
Asn Thr Leu Ser Thr Thr Pro Val Asp Ser Lys Thr Gln Val Ala Thr
1155 1160 1165
Ser Thr Glu Ala Ser Ser Pro Pro Pro Thr Ala Glu Val Thr Ser Met
1170 1175 1180
Pro Thr Ser Thr Pro Gly Glu Arg Ser Thr Pro Leu Thr Ser Met Pro
1185 1190 1195 1200
Val Arg His Thr Pro Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr
1205 1210 1215
Ser Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Ala Glu Thr Ser
1220 1225 1230
Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Leu Pro Thr Ser Thr Thr
1235 1240 1245
Ser Glu Gly Ser Thr Leu Leu Thr Ser Ile Pro Val Ser Thr Thr Leu
1250 1255 1260
Val Thr Ser Pro Glu Ala Ser Thr Leu Leu Thr Thr Pro Val Asp Thr
1265 1270 1275 1280
Lys Gly Pro Val Val Thr Ser Asn Glu Val Ser Ser Ser Pro Thr Pro
1285 1290 1295
Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser Glu Gly Arg Thr
1300 1305 1310
Pro Leu Thr Ser Ile Pro Val Asn Thr Thr Leu Val Ala Ser Ser Ala
1315 1320 1325
Ile Ser Ile Leu Ser Thr Thr Pro Val Asp Asn Ser Thr Pro Val Thr
1330 1335 1340
Thr Ser Thr Glu Ala Cys Ser Ser Pro Thr Thr Ser Glu Gly Thr Ser
1345 1350 1355 1360
Met Pro Asn Ser Asn Pro Ser Glu Gly Thr Thr Pro Leu Thr Ser Ile
1365 1370 1375
Pro Val Ser Thr Thr Pro Val Val Ser Ser Glu Ala Ser Thr Leu Ser
1380 1385 1390
Ala Thr Pro Val Asp Thr Ser Thr Pro Gly Thr Thr Ser Ala Glu Ala
1395 1400 1405
Thr Ser Ser Pro Thr Thr Ala Glu Gly Ile Ser Ile Pro Thr Ser Thr
1410 1415 1420
Pro Ser Glu Gly Lys Thr Pro Leu Lys Ser Ile Pro Val Ser Asn Thr
1425 1430 1435 1440
Pro Val Ala Asn Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp
1445 1450 1455
Ser Asn Ser Pro Val Val Thr Ser Thr Ala Val Ser Ser Ser Pro Thr
1460 1465 1470
Pro Ala Glu Gly Thr Ser Ile Ala Ile Ser Thr Pro Ser Glu Gly Ser
1475 1480 1485
Thr Ala Leu Thr Ser Ile Pro Val Ser Thr Thr Thr Val Ala Ser Ser
1490 1495 1500
Glu Ile Asn Ser Leu Ser Thr Thr Pro Ala Val Thr Ser Thr Pro Val
1505 1510 1515 1520
Thr Thr Tyr Ser Gln Ala Ser Ser Ser Pro Thr Thr Ala Asp Gly Thr
1525 1530 1535
Ser Met Gln Thr Ser Thr Tyr Ser Glu Gly Ser Thr Pro Leu Thr Ser
1540 1545 1550
Leu Pro Val Ser Thr Met Leu Val Val Ser Ser Glu Ala Asn Thr Leu
1555 1560 1565
Ser Thr Thr Pro Ile Asp Ser Lys Thr Gln Val Thr Ala Ser Thr Glu
1570 1575 1580
Ala Ser Ser Ser Thr Thr Ala Glu Gly Ser Ser Met Thr Ile Ser Thr
1585 1590 1595 1600
Pro Ser Glu Gly Ser Pro Leu Leu Thr Ser Ile Pro Val Ser Thr Thr
1605 1610 1615
Pro Val Ala Ser Pro Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp
1620 1625 1630
Ser Asn Ser Pro Val Ile Thr Ser Thr Glu Val Ser Ser Ser Pro Thr
1635 1640 1645
Pro Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr Thr Glu Gly Arg
1650 1655 1660
Thr Pro Leu Thr Ser Ile Thr Val Arg Thr Thr Pro Val Ala Ser Ser
1665 1670 1675 1680
Ala Ile Ser Thr Leu Ser Thr Thr Pro Val Asp Asn Ser Thr Pro Val
1685 1690 1695
Thr Thr Ser Thr Glu Ala Arg Ser Ser Pro Thr Thr Ser Glu Gly Thr
1700 1705 1710
Ser Met Pro Asn Ser Thr Pro Ser Glu Gly Thr Thr Pro Leu Thr Ser
1715 1720 1725
Ile Pro Val Ser Thr Thr Pro Val Leu Ser Ser Glu Ala Ser Thr Leu
1730 1735 1740
Ser Ala Thr Pro Ile Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu
1745 1750 1755 1760
Ala Thr Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Ile Pro Thr Ser
1765 1770 1775
Thr Leu Ser Glu Gly Met Thr Pro Leu Thr Ser Thr Pro Val Ser His
1780 1785 1790
Thr Leu Val Ala Asn Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val
1795 1800 1805
Asp Ser Asn Ser Pro Val Val Thr Ser Thr Ala Val Ser Ser Ser Pro
1810 1815 1820
Thr Pro Ala Glu Gly Thr Ser Ile Ala Thr Ser Thr Pro Ser Glu Gly
1825 1830 1835 1840
Ser Thr Ala Leu Thr Ser Ile Pro Val Ser Thr Thr Thr Val Ala Ser
1845 1850 1855
Ser Glu Thr Asn Thr Leu Ser Thr Thr Pro Ala Val Thr Ser Thr Pro
1860 1865 1870
Val Thr Thr Tyr Ala Gln Val Ser Ser Ser Pro Thr Thr Ala Asp Gly
1875 1880 1885
Ser Ser Met Pro Thr Ser Thr Pro Arg Glu Gly Arg Pro Pro Leu Thr
1890 1895 1900
Ser Ile Pro Val Ser Thr Thr Thr Val Ala Ser Ser Glu Ile Asn Thr
1905 1910 1915 1920
Leu Ser Thr Thr Leu Ala Asp Thr Arg Thr Pro Val Thr Thr Tyr Ser
1925 1930 1935
Gln Ala Ser Ser Ser Pro Thr Thr Ala Asp Gly Thr Ser Met Pro Thr
1940 1945 1950
Pro Ala Tyr Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Leu Ser
1955 1960 1965
Thr Thr Leu Val Val Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro
1970 1975 1980
Val Asp Thr Ser Thr Pro Ala Thr Thr Ser Thr Glu Gly Ser Ser Ser
1985 1990 1995 2000
Pro Thr Thr Ala Gly Gly Thr Ser Ile Gln Thr Ser Thr Pro Ser Glu
2005 2010 2015
Arg Thr Thr Pro Leu Ala Gly Met Pro Val Ser Thr Thr Leu Val Val
2020 2025 2030
Ser Ser Glu Gly Asn Thr Leu Ser Thr Thr Pro Val Asp Ser Lys Thr
2035 2040 2045
Gln Val Thr Asn Ser Thr Glu Ala Ser Ser Ser Ala Thr Ala Glu Gly
2050 2055 2060
Ser Ser Met Thr Ile Ser Ala Pro Ser Glu Gly Ser Pro Leu Leu Thr
2065 2070 2075 2080
Ser Ile Pro Leu Ser Thr Thr Pro Val Ala Ser Pro Glu Ala Ser Thr
2085 2090 2095
Leu Ser Thr Thr Pro Val Asp Ser Asn Ser Pro Val Ile Thr Ser Thr
2100 2105 2110
Glu Val Ser Ser Ser Pro Ile Pro Thr Glu Gly Thr Ser Met Gln Thr
2115 2120 2125
Ser Thr Tyr Ser Asp Arg Arg Thr Pro Leu Thr Ser Met Pro Val Ser
2130 2135 2140
Thr Thr Val Val Ala Ser Ser Ala Ile Ser Thr Leu Ser Thr Thr Pro
2145 2150 2155 2160
Val Asp Thr Ser Thr Pro Val Thr Asn Ser Thr Glu Ala Arg Ser Ser
2165 2170 2175
Pro Thr Thr Ser Glu Gly Thr Ser Met Pro Thr Ser Thr Pro Ser Glu
2180 2185 2190
Gly Ser Thr Pro Phe Thr Ser Met Pro Val Ser Thr Met Pro Val Val
2195 2200 2205
Thr Ser Glu Ala Ser Thr Leu Ser Ala Thr Pro Val Asp Thr Ser Thr
2210 2215 2220
Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Pro Thr Thr Ala Glu
2225 2230 2235 2240
Gly Thr Ser Ile Pro Thr Ser Thr Leu Ser Glu Gly Thr Thr Pro Leu
2245 2250 2255
Thr Ser Ile Pro Val Ser His Thr Leu Val Ala Asn Ser Glu Val Ser
2260 2265 2270
Thr Leu Ser Thr Thr Pro Val Asp Ser Asn Thr Pro Phe Thr Thr Ser
2275 2280 2285
Thr Glu Ala Ser Ser Pro Pro Pro Thr Ala Glu Gly Thr Ser Met Pro
2290 2295 2300
Thr Ser Thr Ser Ser Glu Gly Asn Thr Pro Leu Thr Arg Met Pro Val
2305 2310 2315 2320
Ser Thr Thr Met Val Ala Ser Phe Glu Thr Ser Thr Leu Ser Thr Thr
2325 2330 2335
Pro Ala Asp Thr Ser Thr Pro Val Thr Thr Tyr Ser Gln Ala Gly Ser
2340 2345 2350
Ser Pro Thr Thr Ala Asp Asp Thr Ser Met Pro Thr Ser Thr Tyr Ser
2355 2360 2365
Glu Gly Ser Thr Pro Leu Thr Ser Val Pro Val Ser Thr Met Pro Val
2370 2375 2380
Val Ser Ser Glu Ala Ser Thr His Ser Thr Thr Pro Val Asp Thr Ser
2385 2390 2395 2400
Thr Pro Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala
2405 2410 2415
Glu Gly Thr Ser Ile Pro Thr Ser Pro Pro Ser Glu Gly Thr Thr Pro
2420 2425 2430
Leu Ala Ser Met Pro Val Ser Thr Thr Pro Val Val Ser Ser Glu Ala
2435 2440 2445
Gly Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Met Thr Thr
2450 2455 2460
Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu Asp Ile Val Val
2465 2470 2475 2480
Pro Ile Ser Thr Ala Ser Glu Gly Ser Thr Leu Leu Thr Ser Ile Pro
2485 2490 2495
Val Ser Thr Thr Pro Val Ala Ser Pro Glu Ala Ser Thr Leu Ser Thr
2500 2505 2510
Thr Pro Val Asp Ser Asn Ser Pro Val Val Thr Ser Thr Glu Ile Ser
2515 2520 2525
Ser Ser Ala Thr Ser Ala Glu Gly Thr Ser Met Pro Thr Ser Thr Tyr
2530 2535 2540
Ser Glu Gly Ser Thr Pro Leu Arg Ser Met Pro Val Ser Thr Lys Pro
2545 2550 2555 2560
Leu Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr
2565 2570 2575
Ser Ile Pro Val Thr Thr Ser Thr Glu Thr Ser Ser Ser Pro Thr Thr
2580 2585 2590
Ala Lys Asp Thr Ser Met Pro Ile Ser Thr Pro Ser Glu Val Ser Thr
2595 2600 2605
Ser Leu Thr Ser Ile Leu Val Ser Thr Met Pro Val Ala Ser Ser Glu
2610 2615 2620
Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Arg Thr Leu Val Thr
2625 2630 2635 2640
Thr Ser Thr Gly Thr Ser Ser Ser Pro Thr Thr Ala Glu Gly Ser Ser
2645 2650 2655
Met Pro Thr Ser Thr Pro Gly Glu Arg Ser Thr Pro Leu Thr Asn Ile
2660 2665 2670
Leu Val Ser Thr Thr Leu Leu Ala Asn Ser Glu Ala Ser Thr Leu Ser
2675 2680 2685
Thr Thr Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Ala Glu Ala
2690 2695 2700
Ser Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Met Arg Ile Ser Thr
2705 2710 2715 2720
Pro Ser Asp Gly Ser Thr Pro Leu Thr Ser Ile Leu Val Ser Thr Leu
2725 2730 2735
Pro Val Ala Ser Ser Glu Ala Ser Thr Val Ser Thr Thr Ala Val Asp
2740 2745 2750
Thr Ser Ile Pro Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr
2755 2760 2765
Thr Ala Glu Val Thr Ser Met Pro Thr Ser Thr Pro Ser Glu Thr Ser
2770 2775 2780
Thr Pro Leu Thr Ser Met Pro Val Asn His Thr Pro Val Ala Ser Ser
2785 2790 2795 2800
Glu Ala Gly Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr Pro Val
2805 2810 2815
Thr Thr Ser Thr Lys Ala Ser Ser Ser Pro Thr Thr Ala Glu Gly Ile
2820 2825 2830
Val Val Pro Ile Ser Thr Ala Ser Glu Gly Ser Thr Leu Leu Thr Ser
2835 2840 2845
Ile Pro Val Ser Thr Thr Pro Val Ala Ser Ser Glu Ala Ser Thr Leu
2850 2855 2860
Ser Thr Thr Pro Val Asp Thr Ser Ile Pro Val Thr Thr Ser Thr Glu
2865 2870 2875 2880
Gly Ser Ser Ser Pro Thr Thr Ala Glu Gly Thr Ser Met Pro Ile Ser
2885 2890 2895
Thr Pro Ser Glu Val Ser Thr Pro Leu Thr Ser Ile Leu Val Ser Thr
2900 2905 2910
Val Pro Val Ala Gly Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val
2915 2920 2925
Asp Thr Arg Thr Pro Val Thr Thr Ser Ala Glu Ala Ser Ser Ser Pro
2930 2935 2940
Thr Thr Ala Glu Gly Thr Ser Met Pro Ile Ser Thr Pro Gly Glu Arg
2945 2950 2955 2960
Arg Thr Pro Leu Thr Ser Met Ser Val Ser Thr Met Pro Val Ala Ser
2965 2970 2975
Ser Glu Ala Ser Thr Leu Ser Arg Thr Pro Ala Asp Thr Ser Thr Pro
2980 2985 2990
Val Thr Thr Ser Thr Glu Ala Ser Ser Ser Pro Thr Thr Ala Glu Gly
2995 3000 3005
Thr Gly Ile Pro Ile Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr
3010 3015 3020
Ser Ile Pro Val Ser Thr Thr Pro Val Ala Ile Pro Glu Ala Ser Thr
3025 3030 3035 3040
Leu Ser Thr Thr Pro Val Asp Ser Asn Ser Pro Val Val Thr Ser Thr
3045 3050 3055
Glu Val Ser Ser Ser Pro Thr Pro Ala Glu Gly Thr Ser Met Pro Ile
3060 3065 3070
Ser Thr Tyr Ser Glu Gly Ser Thr Pro Leu Thr Gly Val Pro Val Ser
3075 3080 3085
Thr Thr Pro Val Thr Ser Ser Ala Ile Ser Thr Leu Ser Thr Thr Pro
3090 3095 3100
Val Asp Thr Ser Thr Pro Val Thr Thr Ser Thr Glu Ala His Ser Ser
3105 3110 3115 3120
Pro Thr Thr Ser Glu Gly Thr Ser Met Pro Thr Ser Thr Pro Ser Glu
3125 3130 3135
Gly Ser Thr Pro Leu Thr Tyr Met Pro Val Ser Thr Met Leu Val Val
3140 3145 3150
Ser Ser Glu Asp Ser Thr Leu Ser Ala Thr Pro Val Asp Thr Ser Thr
3155 3160 3165
Pro Val Thr Thr Ser Thr Glu Ala Thr Ser Ser Thr Thr Ala Glu Gly
3170 3175 3180
Thr Ser Ile Pro Thr Ser Thr Pro Ser Glu Gly Met Thr Pro Leu Thr
3185 3190 3195 3200
Ser Val Pro Val Ser Asn Thr Pro Val Ala Ser Ser Glu Ala Ser Ile
3205 3210 3215
Leu Ser Thr Thr Pro Val Asp Ser Asn Thr Pro Leu Thr Thr Ser Thr
3220 3225 3230
Glu Ala Ser Ser Ser Pro Pro Thr Ala Glu Gly Thr Ser Met Pro Thr
3235 3240 3245
Ser Thr Pro Ser Glu Gly Ser Thr Pro Leu Thr Ser Met Pro Val Ser
3250 3255 3260
Thr Thr Thr Val Ala Ser Ser Glu Thr Ser Thr Leu Ser Thr Thr Pro
3265 3270 3275 3280
Ala Asp Thr Ser Thr Pro Val Thr Thr Tyr Ser Gln Ala Ser Ser Ser
3285 3290 3295
Pro Pro Ile Ala Asp Gly Thr Ser Met Pro Thr Ser Thr Tyr Ser Glu
3300 3305 3310
Gly Ser Thr Pro Leu Thr Asn Met Ser Phe Ser Thr Thr Pro Val Val
3315 3320 3325
Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Thr Ser Thr
3330 3335 3340
Pro Val Thr Thr Ser Thr Glu Ala Ser Leu Ser Pro Thr Thr Ala Glu
3345 3350 3355 3360
Gly Thr Ser Ile Pro Thr Ser Ser Pro Ser Glu Gly Thr Thr Pro Leu
3365 3370 3375
Ala Ser Met Pro Val Ser Thr Thr Pro Val Val Ser Ser Glu Val Asn
3380 3385 3390
Thr Leu Ser Thr Thr Pro Val Asp Ser Asn Thr Leu Val Thr Thr Ser
3395 3400 3405
Thr Glu Ala Ser Ser Ser Pro Thr Ile Ala Glu Gly Thr Ser Leu Pro
3410 3415 3420
Thr Ser Thr Thr Ser Glu Gly Ser Thr Pro Leu Ser Ile Met Pro Leu
3425 3430 3435 3440
Ser Thr Thr Pro Val Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr
3445 3450 3455
Pro Val Asp Thr Ser Thr Pro Val Thr Thr Ser Ser Pro Thr Asn Ser
3460 3465 3470
Ser Pro Thr Thr Ala Glu Val Thr Ser Met Pro Thr Ser Thr Ala Gly
3475 3480 3485
Glu Gly Ser Thr Pro Leu Thr Asn Met Pro Val Ser Thr Thr Pro Val
3490 3495 3500
Ala Ser Ser Glu Ala Ser Thr Leu Ser Thr Thr Pro Val Asp Ser Asn
3505 3510 3515 3520
Thr Phe Val Thr Ser Ser Ser Gln Ala Ser Ser Ser Pro Ala Thr Leu
3525 3530 3535
Gln Val Thr Thr Met Arg Met Ser Thr Pro Ser Glu Gly Ser Ser Ser
3540 3545 3550
Leu Thr Thr Met Leu Leu Ser Ser Thr Tyr Val Thr Ser Ser Glu Ala
3555 3560 3565
Ser Thr Pro Ser Thr Pro Ser Val Asp Arg Ser Thr Pro Val Thr Thr
3570 3575 3580
Ser Thr Gln Ser Asn Ser Thr Pro Thr Pro Pro Glu Val Ile Thr Leu
3585 3590 3595 3600
Pro Met Ser Thr Pro Ser Glu Val Ser Thr Pro Leu Thr Ile Met Pro
3605 3610 3615
Val Ser Thr Thr Ser Val Thr Ile Ser Glu Ala Gly Thr Ala Ser Thr
3620 3625 3630
Leu Pro Val Asp Thr Ser Thr Pro Val Ile Thr Ser Thr Gln Val Ser
3635 3640 3645
Ser Ser Pro Val Thr Pro Glu Gly Thr Thr Met Pro Ile Trp Thr Pro
3650 3655 3660
Ser Glu Gly Ser Thr Pro Leu Thr Thr Met Pro Val Ser Thr Thr Arg
3665 3670 3675 3680
Val Thr Ser Ser Glu Gly Ser Thr Leu Ser Thr Pro Ser Val Val Thr
3685 3690 3695
Ser Thr Pro Val Thr Thr Ser Thr Glu Ala Ile Ser Ser Ser Ala Thr
3700 3705 3710
Leu Asp Ser Thr Thr Met Ser Val Ser Met Pro Met Glu Ile Ser Thr
3715 3720 3725
Leu Gly Thr Thr Ile Leu Val Ser Thr Thr Pro Val Thr Arg Phe Pro
3730 3735 3740
Glu Ser Ser Thr Pro Ser Ile Pro Ser Val Tyr Thr Ser Met Ser Met
3745 3750 3755 3760
Thr Thr Ala Ser Glu Gly Ser Ser Ser Pro Thr Thr Leu Glu Gly Thr
3765 3770 3775
Thr Thr Met Pro Met Ser Thr Thr Ser Glu Arg Ser Thr Leu Leu Thr
3780 3785 3790
Thr Val Leu Ile Ser Pro Ile Ser Val Met Ser Pro Ser Glu Ala Ser
3795 3800 3805
Thr Leu Ser Thr Pro Pro Gly Asp Thr Ser Thr Pro Leu Leu Thr Ser
3810 3815 3820
Thr Lys Ala Gly Ser Phe Ser Ile Pro Ala Glu Val Thr Thr Ile Arg
3825 3830 3835 3840
Ile Ser Ile Thr Ser Glu Arg Ser Thr Pro Leu Thr Thr Leu Leu Val
3845 3850 3855
Ser Thr Thr Leu Pro Thr Ser Phe Pro Gly Ala Ser Ile Ala Ser Thr
3860 3865 3870
Pro Pro Leu Asp Thr Ser Thr Thr Phe Thr Pro Ser Thr Asp Thr Ala
3875 3880 3885
Ser Thr Pro Thr Ile Pro Val Ala Thr Thr Ile Ser Val Ser Val Ile
3890 3895 3900
Thr Glu Gly Ser Thr Pro Gly Thr Thr Ile Phe Ile Pro Ser Thr Pro
3905 3910 3915 3920
Val Thr Ser Ser Thr Ala Asp Val Phe Pro Ala Thr Thr Gly Ala Val
3925 3930 3935
Ser Thr Pro Val Ile Thr Ser Thr Glu Leu Asn Thr Pro Ser Thr Ser
3940 3945 3950
Ser Ser Ser Thr Thr Thr Ser Phe Ser Thr Thr Lys Glu Phe Thr Thr
3955 3960 3965
Pro Ala Met Thr Thr Ala Ala Pro Leu Thr Tyr Val Thr Met Ser Thr
3970 3975 3980
Ala Pro Ser Thr Pro Arg Thr Thr Ser Arg Gly Cys Thr Thr Ser Ala
3985 3990 3995 4000
Ser Thr Leu Ser Ala Thr Ser Thr Pro His Thr Ser Thr Ser Val Thr
4005 4010 4015
Thr Arg Pro Val Thr Pro Ser Ser Glu Ser Ser Arg Pro Ser Thr Ile
4020 4025 4030
Thr Ser His Thr Ile Pro Pro Thr Phe Pro Pro Ala His Ser Ser Thr
4035 4040 4045
Pro Pro Thr Thr Ser Ala Ser Ser Thr Thr Val Asn Pro Glu Ala Val
4050 4055 4060
Thr Thr Met Thr Thr Arg Thr Lys Pro Ser Thr Arg Thr Thr Ser Phe
4065 4070 4075 4080
Pro Thr Val Thr Thr Thr Ala Val Pro Thr Asn Thr Thr Ile Lys Ser
4085 4090 4095
Asn Pro Thr Ser Thr Pro Thr Val Pro Arg Thr Thr Thr Cys Phe Gly
4100 4105 4110
Asp Gly Cys Gln Asn Thr Ala Ser Arg Cys Lys Asn Gly Gly Thr Trp
4115 4120 4125
Asp Gly Leu Lys Cys Gln Cys Pro Asn Leu Tyr Tyr Gly Glu Leu Cys
4130 4135 4140
Glu Glu Val Val Ser Ser Ile Asp Ile Gly Pro Pro Glu Thr Ile Ser
4145 4150 4155 4160
Ala Gln Met Glu Leu Thr Val Thr Val Thr Ser Val Lys Phe Thr Glu
4165 4170 4175
Glu Leu Lys Asn His Ser Ser Gln Glu Phe Gln Glu Phe Lys Gln Thr
4180 4185 4190
Phe Thr Glu Gln Met Asn Ile Val Tyr Ser Gly Ile Pro Glu Tyr Val
4195 4200 4205
Gly Val Asn Ile Thr Lys Leu Arg Leu Gly Ser Val Val Val Glu His
4210 4215 4220
Asp Val Leu Leu Arg Thr Lys Tyr Thr Pro Glu Tyr Lys Thr Val Leu
4225 4230 4235 4240
Asp Asn Ala Thr Glu Val Val Lys Glu Lys Ile Thr Lys Val Thr Thr
4245 4250 4255
Gln Gln Ile Met Ile Asn Asp Ile Cys Ser Asp Met Met Cys Phe Asn
4260 4265 4270
Thr Thr Gly Thr Gln Val Gln Asn Ile Thr Val Thr Gln Tyr Asp Pro
4275 4280 4285
Glu Glu Asp Cys Arg Lys Met Ala Lys Glu Tyr Gly Asp Tyr Phe Val
4290 4295 4300
Val Glu Tyr Arg Asp Gln Lys Pro Tyr Cys Ile Ser Pro Cys Glu Pro
4305 4310 4315 4320
Gly Phe Ser Val Ser Lys Asn Cys Asn Leu Gly Lys Cys Gln Met Ser
4325 4330 4335
Leu Ser Gly Pro Gln Cys Leu Cys Val Thr Thr Glu Thr His Trp Tyr
4340 4345 4350
Ser Gly Glu Thr Cys Asn Gln Gly Thr Gln Lys Ser Leu Val Tyr Gly
4355 4360 4365
<210> 23
<211> 407
<212> PRT
<213> 智人（Homo sapiens）
<400> 23
Ser Gln Val Ser Gln Asn Cys His Asn Gly Ser Tyr Glu Ile Ser Val
1 5 10 15
Leu Met Met Gly Asn Ser Ala Phe Ala Glu Pro Leu Lys Asn Leu Glu
20 25 30
Asp Ala Val Asn Glu Gly Leu Glu Ile Val Arg Gly Arg Leu Gln Asn
35 40 45
Ala Gly Leu Asn Val Thr Val Asn Ala Thr Phe Met Tyr Ser Asp Gly
50 55 60
Leu Ile His Asn Ser Gly Asp Cys Arg Ser Ser Thr Cys Glu Gly Leu
65 70 75 80
Asp Leu Leu Arg Lys Ile Ser Asn Ala Gln Arg Met Gly Cys Val Leu
85 90 95
Ile Gly Pro Ser Cys Thr Tyr Ser Thr Phe Gln Met Tyr Leu Asp Thr
100 105 110
Glu Leu Ser Tyr Pro Met Ile Ser Ala Gly Ser Phe Gly Leu Ser Cys
115 120 125
Asp Tyr Lys Glu Thr Leu Thr Arg Leu Met Ser Pro Ala Arg Lys Leu
130 135 140
Met Tyr Phe Leu Val Asn Phe Trp Lys Thr Asn Asp Leu Pro Phe Lys
145 150 155 160
Thr Tyr Ser Trp Ser Thr Ser Tyr Val Tyr Lys Asn Gly Thr Glu Thr
165 170 175
Glu Asp Cys Phe Trp Tyr Leu Asn Ala Leu Glu Ala Ser Val Ser Tyr
180 185 190
Phe Ser His Glu Leu Gly Phe Lys Val Val Leu Arg Gln Asp Lys Glu
195 200 205
Phe Gln Asp Ile Leu Met Asp His Asn Arg Lys Ser Asn Val Ile Ile
210 215 220
Met Cys Gly Gly Pro Glu Phe Leu Tyr Lys Leu Lys Gly Asp Arg Ala
225 230 235 240
Val Ala Glu Asp Ile Val Ile Ile Leu Val Asp Leu Phe Asn Asp Gln
245 250 255
Tyr Phe Glu Asp Asn Val Thr Ala Pro Asp Tyr Met Lys Asn Val Leu
260 265 270
Val Leu Thr Leu Ser Pro Gly Asn Ser Leu Leu Asn Ser Ser Phe Ser
275 280 285
Arg Asn Leu Ser Pro Thr Lys Arg Asp Phe Ala Leu Ala Tyr Leu Asn
290 295 300
Gly Ile Leu Leu Phe Gly His Met Leu Lys Ile Phe Leu Glu Asn Gly
305 310 315 320
Glu Asn Ile Thr Thr Pro Lys Phe Ala His Ala Phe Arg Asn Leu Thr
325 330 335
Phe Glu Gly Tyr Asp Gly Pro Val Thr Leu Asp Asp Trp Gly Asp Val
340 345 350
Asp Ser Thr Met Val Leu Leu Tyr Thr Ser Val Asp Thr Lys Lys Tyr
355 360 365
Lys Val Leu Leu Thr Tyr Asp Thr His Val Asn Lys Thr Tyr Pro Val
370 375 380
Asp Met Ser Pro Thr Phe Thr Trp Lys Asn Ser Lys Leu Pro Asn Asp
385 390 395 400
Ile Thr Gly Arg Gly Pro Gln
405
<210> 24
<211> 264
<212> PRT
<213> 智人（Homo sapiens）
<400> 24
Pro Arg Phe Met Gly Thr Ile Ser Asp Val Lys Thr Asn Val Gln Leu
1 5 10 15
Leu Lys Gly Arg Val Asp Asn Ile Ser Thr Leu Asp Ser Glu Ile Lys
20 25 30
Lys Asn Ser Asp Gly Met Glu Ala Ala Gly Val Gln Ile Gln Met Val
35 40 45
Asn Glu Ser Leu Gly Tyr Val Arg Ser Gln Phe Leu Lys Leu Lys Thr
50 55 60
Ser Val Glu Lys Ala Asn Ala Gln Ile Gln Ile Leu Thr Arg Ser Trp
65 70 75 80
Glu Glu Val Ser Thr Leu Asn Ala Gln Ile Pro Glu Leu Lys Ser Asp
85 90 95
Leu Glu Lys Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly
100 105 110
Ser Leu Glu Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu
115 120 125
Gln Val Val Ser Gln Gly Trp Lys Tyr Phe Lys Gly Asn Phe Tyr Tyr
130 135 140
Phe Ser Leu Ile Pro Lys Thr Trp Tyr Ser Ala Glu Gln Phe Cys Val
145 150 155 160
Ser Arg Asn Ser His Leu Thr Ser Val Thr Ser Glu Ser Glu Gln Glu
165 170 175
Phe Leu Tyr Lys Thr Ala Gly Gly Leu Ile Tyr Trp Ile Gly Leu Thr
180 185 190
Lys Ala Gly Met Glu Gly Asp Trp Ser Trp Val Asp Asp Thr Pro Phe
195 200 205
Asn Lys Val Gln Ser Val Arg Phe Trp Ile Pro Gly Glu Pro Asn Asn
210 215 220
Ala Gly Asn Asn Glu His Cys Gly Asn Ile Lys Ala Pro Ser Leu Gln
225 230 235 240
Ala Trp Asn Asp Ala Pro Cys Asp Lys Thr Phe Leu Phe Ile Cys Lys
245 250 255
Arg Pro Tyr Val Pro Ser Glu Pro
260
<210> 25
<211> 100
<212> PRT
<213> 智人（Homo sapiens）
<400> 25
Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val
1 5 10 15
Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly
20 25 30
Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu
35 40 45
Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu
50 55 60
Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly
65 70 75 80
Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val
85 90 95
Cys Glu Asn Cys
100
<210> 26
<211> 371
<212> PRT
<213> 智人（Homo sapiens）
<400> 26
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
50 55 60
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
100 105 110
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
115 120 125
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
130 135 140
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
145 150 155 160
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
165 170 175
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
180 185 190
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
195 200 205
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
210 215 220
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
225 230 235 240
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
245 250 255
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
260 265 270
Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
275 280 285
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
290 295 300
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
305 310 315 320
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
325 330 335
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
340 345 350
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
355 360 365
Val Gln Pro
370
<210> 27
<211> 348
<212> PRT
<213> 智人（Homo sapiens）
<400> 27
Arg Leu Ser Trp Tyr Asp Pro Asp Phe Gln Ala Arg Leu Thr Arg Ser
1 5 10 15
Asn Ser Lys Cys Gln Gly Gln Leu Glu Val Tyr Leu Lys Asp Gly Trp
20 25 30
His Met Val Cys Ser Gln Ser Trp Gly Arg Ser Ser Lys Gln Trp Glu
35 40 45
Asp Pro Ser Gln Ala Ser Lys Val Cys Gln Arg Leu Asn Cys Gly Val
50 55 60
Pro Leu Ser Leu Gly Pro Phe Leu Val Thr Tyr Thr Pro Gln Ser Ser
65 70 75 80
Ile Ile Cys Tyr Gly Gln Leu Gly Ser Phe Ser Asn Cys Ser His Ser
85 90 95
Arg Asn Asp Met Cys His Ser Leu Gly Leu Thr Cys Leu Glu Pro Gln
100 105 110
Lys Thr Thr Pro Pro Thr Thr Arg Pro Pro Pro Thr Thr Thr Pro Glu
115 120 125
Pro Thr Ala Pro Pro Arg Leu Gln Leu Val Ala Gln Ser Gly Gly Gln
130 135 140
His Cys Ala Gly Val Val Glu Phe Tyr Ser Gly Ser Leu Gly Gly Thr
145 150 155 160
Ile Ser Tyr Glu Ala Gln Asp Lys Thr Gln Asp Leu Glu Asn Phe Leu
165 170 175
Cys Asn Asn Leu Gln Cys Gly Ser Phe Leu Lys His Leu Pro Glu Thr
180 185 190
Glu Ala Gly Arg Ala Gln Asp Pro Gly Glu Pro Arg Glu His Gln Pro
195 200 205
Leu Pro Ile Gln Trp Lys Ile Gln Asn Ser Ser Cys Thr Ser Leu Glu
210 215 220
His Cys Phe Arg Lys Ile Lys Pro Gln Lys Ser Gly Arg Val Leu Ala
225 230 235 240
Leu Leu Cys Ser Gly Phe Gln Pro Lys Val Gln Ser Arg Leu Val Gly
245 250 255
Gly Ser Ser Ile Cys Glu Gly Thr Val Glu Val Arg Gln Gly Ala Gln
260 265 270
Trp Ala Ala Leu Cys Asp Ser Ser Ser Ala Arg Ser Ser Leu Arg Trp
275 280 285
Glu Glu Val Cys Arg Glu Gln Gln Cys Gly Ser Val Asn Ser Tyr Arg
290 295 300
Val Leu Asp Ala Gly Asp Pro Thr Ser Arg Gly Leu Phe Cys Pro His
305 310 315 320
Gln Lys Leu Ser Gln Cys His Glu Leu Trp Glu Arg Asn Ser Tyr Cys
325 330 335
Lys Lys Val Phe Val Thr Cys Gln Asp Pro Asn Pro
340 345
<210> 28
<211> 7902
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 28
gtcgacacta gtaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt 60
aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct 120
attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt 180
tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac 240
gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct 300
ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca 360
ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt 420
ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc 480
ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct 540
cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg 600
cctgccgcgg aattcgagct cggtaccttt aagaccaatg acttacaagg cagctgtaga 660
tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag 720
acaagatctg ctttttgctt gtactgagtc tctctggtta gaccagatct gagcctggga 780
gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct 840
tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt 900
ttagtcagtg tggaaaatct ctagcagtag tagttcatgt catcttatta ttcagtattt 960
ataacttgca aagaaatgaa tatcagagag tgagaggaac ttgtttattg cagcttataa 1020
tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca 1080
ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctggc tctagctatc 1140
ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca ttctccgccc 1200
catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta 1260
ttccagaagt agtgaggagg cttttttgga ggcctaggga cgtacccaat tcgccctata 1320
gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc 1380
ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 1440
gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg 1500
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg 1560
ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca 1620
cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta 1680
gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc 1740
catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg 1800
gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat 1860
aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta 1920
acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt 1980
gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag 2040
acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca 2100
tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc 2160
agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat 2220
cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc 2280
aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg 2340
gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc 2400
agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat 2460
aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga 2520
gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc 2580
ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc 2640
aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt 2700
aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc 2760
tggctggttt attgctgata aatctggagc cggtgagcgt ggctctcgcg gtatcattgc 2820
agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca 2880
ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca 2940
ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt 3000
ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta 3060
acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg 3120
agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc 3180
ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag 3240
cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa 3300
gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc 3360
cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc 3420
gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta 3480
caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag 3540
aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct 3600
tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga 3660
gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc 3720
ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt 3780
atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg 3840
cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg 3900
caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc 3960
cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc 4020
accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata 4080
acaatttcac acaggaaaca gctatgacca tgattacgcc aagcgcgcaa ttaaccctca 4140
ctaaagggaa caaaagctgg agctgcaagc ttaatgtagt cttatgcaat actcttgtag 4200
tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa aaagcaccgt 4260
gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag gcaacagacg 4320
ggtctgacat ggattggacg aaccactgaa ttgccgcatt gcagagatat tgtatttaag 4380
tgcctagctc gatacataaa cggctctctc tggttagacc agatctgagc ctgggagctc 4440
tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa 4500
gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag 4560
tcagtgtgga aaatctctag cagtggcgcc cgaacaggga cttgaaagcg aaagggaaac 4620
cagaggagct ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg 4680
ggcggcgact ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg 4740
ggtgcgagag cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt 4800
taaggccagg gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc 4860
tagaacgatt cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac 4920
tgggacagct acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata 4980
cagtagcaac cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt 5040
tagacaagat agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg 5100
atcttcagac ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat 5160
aaagtagtaa aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg 5220
cagagagaaa aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca 5280
ggaagcacta tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct 5340
ggtatagtgc agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg 5400
caactcacag tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac 5460
ctaaaggatc aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact 5520
gctgtgcctt ggaatgctag ttggagtaat aaatctctgg aacagatttg gaatcacacg 5580
acctggatgg agtgggacag agaaattaac aattacacaa gcttaataca ctccttaatt 5640
gaagaatcgc aaaaccagca agaaaagaat gaacaagaat tattggaatt agataaatgg 5700
gcaagtttgt ggaattggtt taacataaca aattggctgt ggtatataaa attattcata 5760
atgatagtag gaggcttggt aggtttaaga atagtttttg ctgtactttc tatagtgaat 5820
agagttaggc agggatattc accattatcg tttcagaccc acctcccaac cccgagggga 5880
cccgacaggc ccgaaggaat agaagaagaa ggtggagaga gagacagaga cagatccatt 5940
cgattagtga acggatctcg acggtatcga tcacgagact agcctcgaca caaatggcag 6000
tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa 6060
tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa attacaaaaa 6120
ttcaaaattt tcgggtttat tacagggaca gcagaaatcc actttggctc gagaagcttg 6180
atatcggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt 6240
tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg 6300
aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa 6360
gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggatc 6420
cgccaccatg gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc 6480
cgccaggccg gatatccaga tgacccagag cccgagcagc ctgagcgcga gcgtgggtga 6540
tcgcgtgacc attacctgca gggcaagtca ggacattagt aaatatttaa attggtatca 6600
gcagaaaccg ggtaaagcgc cgaaactgtt aatttatcat acatcaagat tacactcagg 6660
cgtgccgtcg cgttttagcg gctcgggttc gggcaccgat tttaccctga ccatctcgag 6720
cttgcagccg gaggacttcg ccacctacta ttgccaacag ggtaatacgc ttccgtacac 6780
gttcggtcag ggcaccaaag tggagatcaa aggtggcggt ggctcgggcg gtggtgggtc 6840
gggtggcggc ggatctgagg tgcagctggt ggagtctggg ggaggcttgg tacagcctgg 6900
ggggtccctg agactctcct gtgcagcctc tggagtgtcc ctgcctgatt atggcgtgtc 6960
ctgggtccgc caggctccag ggaaggggct ggagtgggtt tcagtgatct ggggcagcga 7020
gacaacctac tacaacagcg ccctgaagtc ccgattcacc atctccagag acaatgccaa 7080
gaactcactg tatctgcaaa tgaacagcct gagagccgag gacacggctg tgtattactg 7140
tgcgaagcac tactactacg gcggcagcta cgctatggac tactggggcc aaggaaccct 7200
ggtcaccgtg tcctcaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat 7260
cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt 7320
gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac 7380
ttgtggggtc cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa 7440
actcctgtat atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga 7500
tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt 7560
cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct 7620
caatctagga cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga 7680
gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa 7740
agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa 7800
ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct 7860
tcacatgcag gccctgcccc ctcgctaatc tagaggcgcg cc 7902
<210> 29
<211> 66
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 29
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
35 40 45
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
50 55 60
Ile Thr
65
<210> 30
<211> 69
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 30
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
35 40 45
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
50 55 60
Ile Thr Leu Tyr Cys
65
<210> 31
<211> 72
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 31
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
50 55 60
Ser Leu Val Ile Thr Leu Tyr Cys
65 70
<210> 32
<211> 69
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 32
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
50 55 60
Ser Leu Val Ile Thr
65
<210> 33
<211> 50
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 33
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr
50
<210> 34
<211> 50
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 34
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr
50
<210> 35
<211> 47
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 35
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
35 40 45
<210> 36
<211> 47
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 36
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
35 40 45
<210> 37
<211> 22
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 37
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
1 5 10 15
Val Ile Thr Leu Tyr Cys
20
<210> 38
<211> 22
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 38
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
1 5 10 15
Val Ile Thr Leu Tyr Cys
20
<210> 39
<211> 270
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 39
Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val
1 5 10 15
Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr
20 25 30
Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly
35 40 45
Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe
50 55 60
Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro
65 70 75 80
Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val
85 90 95
Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly
100 105 110
Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro
115 120 125
Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg
130 135 140
Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser
145 150 155 160
Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr
165 170 175
Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro
180 185 190
Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser
195 200 205
Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu
210 215 220
Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr
225 230 235 240
Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr
245 250 255
Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly
260 265 270
<210> 40
<211> 19
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 40
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
1 5 10 15
Val Ile Thr
<210> 41
<211> 339
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 41
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc 60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc 120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat 180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc 240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc 300
tacgacgccc ttcacatgca ggccctgccc cctcgctaa 339
<210> 42
<211> 1689
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 42
cggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg 60
gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag 120
tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc 180
agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggatccgcc 240
accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc 300
aggccggaca tccagctcac ccagtccccg agctcgctgt ccgcctccgt gggagatcgg 360
gtcaccatca cgtgccgcgc cagccagtcg atttcctcct acctgaactg gtaccaacag 420
aagcccggaa aagccccgaa gcttctcatc tacgccgcct cgagcctgca gtcaggagtg 480
ccctcacggt tctccggctc cggttccggt actgatttca ccctgaccat ttcctccctg 540
caaccggagg acttcgctac ttactactgc cagcagtcgt actccacccc ctacactttc 600
ggacaaggca ccaaggtcga aatcaagggt ggcggtggct cgggcggtgg tgggtcgggt 660
ggcggcggat ctgaagtgca attggtggaa tcagggggag gacttgtgca gcctggagga 720
tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt ccaaccacgg gatgtcctgg 780
gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg gtattgtgta cagcggtagc 840
acctactatg ccgcatccgt gaaggggaga ttcaccatca gccgggacaa ctccaggaac 900
actctgtacc tccaaatgaa ttcgctgagg ccagaggaca ctgccatcta ctactgctcc 960
gcgcatggcg gagagtccga cgtctgggga caggggacca ccgtgaccgt gtctagcacc 1020
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc 1080
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac 1140
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg 1200
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa 1260
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt 1320
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc 1380
cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag 1440
gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga 1500
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc 1560
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac 1620
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc 1680
cctcgctaa 1689
<210> 43
<211> 1689
<212> DNA
<213> 智人（Homo sapiens）
<400> 43
cggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg 60
gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag 120
tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc 180
agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggatccgcc 240
accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc 300
aggccggaca tccagctcac ccagtccccg agctcgctgt ccgcctccgt gggagatcgg 360
gtcaccatca cgtgccgcgc cagccagtcg atttcctcct acctgaactg gtaccaacag 420
aagcccggaa aagccccgaa gcttctcatc tacgccgcct cgagcctgca gtcaggagtg 480
ccctcacggt tctccggctc cggttccggt actgatttca ccctgaccat ttcctccctg 540
caaccggagg acttcgctac ttactactgc cagcagtcgt actccacccc ctacactttc 600
ggacaaggca ccaaggtcga aatcaagggt ggcggtggct cgggcggtgg tgggtcgggt 660
ggcggcggat ctgaagtgca attggtggaa tcagggggag gacttgtgca gcctggagga 720
tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt ccaaccacgg gatgtcctgg 780
gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg gtattgtgta cagcggtagc 840
acctactatg ccgcatccgt gaaggggaga ttcaccatca gccgggacaa ctccaggaac 900
actctgtacc tccaaatgaa ttcgctgagg ccagaggaca ctgccatcta ctactgctcc 960
gcgcatggcg gagagtccga cgtctgggga caggggacca ccgtgaccgt gtctagcacc 1020
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc 1080
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac 1140
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg 1200
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa 1260
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt 1320
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc 1380
cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag 1440
gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga 1500
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc 1560
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac 1620
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc 1680
cctcgctaa 1689
<210> 44
<211> 1689
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 44
cggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg 60
gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag 120
tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc 180
agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggatccgcc 240
accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc 300
aggccggaca tccagctcac ccagtccccg agctcgctgt ccgcctccgt gggagatcgg 360
gtcaccatca cgtgccgcgc cagccagtcg atttcctcct acctgaactg gtaccaacag 420
aagcccggaa aagccccgaa gcttctcatc tacgccgcct cgagcctgca gtcaggagtg 480
ccctcacggt tctccggctc cggttccggt actgatttca ccctgaccat ttcctccctg 540
caaccggagg acttcgctac ttactactgc cagcagtcgt actccacccc ctacactttc 600
ggacaaggca ccaaggtcga aatcaagggt ggcggtggct cgggcggtgg tgggtcgggt 660
ggcggcggat ctgaagtgca attggtggaa tcagggggag gacttgtgca gcctggagga 720
tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt ccaaccacgg gatgtcctgg 780
gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg gtattgtgta cagcggtagc 840
acctactatg ccgcatccgt gaaggggaga ttcaccatca gccgggacaa ctccaggaac 900
actctgtacc tccaaatgaa ttcgctgagg ccagaggaca ctgccatcta ctactgctcc 960
gcgcatggcg gagagtccga cgtctgggga caggggacca ccgtgaccgt gtctagcacc 1020
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc 1080
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac 1140
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg 1200
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa 1260
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt 1320
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc 1380
cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag 1440
gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga 1500
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc 1560
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac 1620
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc 1680
cctcgctaa 1689
<210> 45
<211> 1689
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 45
cggctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg 60
gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag 120
tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc 180
agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggatccgcc 240
accatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc 300
aggccggaca tccagctcac ccagtccccg agctcgctgt ccgcctccgt gggagatcgg 360
gtcaccatca cgtgccgcgc cagccagtcg atttcctcct acctgaactg gtaccaacag 420
aagcccggaa aagccccgaa gcttctcatc tacgccgcct cgagcctgca gtcaggagtg 480
ccctcacggt tctccggctc cggttccggt actgatttca ccctgaccat ttcctccctg 540
caaccggagg acttcgctac ttactactgc cagcagtcgt actccacccc ctacactttc 600
ggacaaggca ccaaggtcga aatcaagggt ggcggtggct cgggcggtgg tgggtcgggt 660
ggcggcggat ctgaagtgca attggtggaa tcagggggag gacttgtgca gcctggagga 720
tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt ccaaccacgg gatgtcctgg 780
gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg gtattgtgta cagcggtagc 840
acctactatg ccgcatccgt gaaggggaga ttcaccatca gccgggacaa ctccaggaac 900
actctgtacc tccaaatgaa ttcgctgagg ccagaggaca ctgccatcta ctactgctcc 960
gcgcatggcg gagagtccga cgtctgggga caggggacca ccgtgaccgt gtctagcacc 1020
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc 1080
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac 1140
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg 1200
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa 1260
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt 1320
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc 1380
cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag 1440
gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga 1500
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc 1560
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac 1620
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc 1680
cctcgctaa 1689
<210> 46
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 46
Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Val Gly Thr Ala
20 25 30
Val Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile
35 40 45
Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys His Gln Tyr Asn Ser Tyr Asn Thr
85 90 95
Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 47
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 47
Gln Val Thr Leu Lys Glu Ser Gly Pro Val Leu Val Lys Pro Thr Glu
1 5 10 15
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser
20 25 30
Gly Met Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45
Trp Val Ala His Ile Trp Trp Asp Asp Asp Val Tyr Tyr Asn Pro Ser
50 55 60
Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Ala Ser Lys Asp Gln Val
65 70 75 80
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
85 90 95
Cys Val Arg Arg Arg Ala Thr Gly Thr Gly Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 48
<211> 130
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
1 5 10 15
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val
20 25 30
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val
35 40 45
Ser Ile Ser Ser His Asp Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly
50 55 60
Gln Gln Pro Lys Leu Leu Ile Tyr Asp Ala Phe Asn Leu Ala Ser Gly
65 70 75 80
Ile Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
85 90 95
Thr Ile Asp Pro Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln
100 105 110
Gln Ser Lys Asp Asp Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu
115 120 125
Leu Lys
130
<210> 49
<211> 139
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 49
Met Asp Ile Arg Leu Ser Leu Ala Phe Leu Val Leu Phe Ile Lys Gly
1 5 10 15
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
20 25 30
Pro Gly Arg Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
35 40 45
Ser Asn Tyr Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu
50 55 60
Glu Trp Val Ala Thr Ile Ser Tyr Asp Gly Ser Ile Thr Tyr Tyr Arg
65 70 75 80
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Ser
85 90 95
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr
100 105 110
Tyr Tyr Cys Thr Arg Glu Glu Gln Tyr Ser Ser Trp Tyr Phe Asp Phe
115 120 125
Trp Gly Pro Gly Ile Met Val Thr Val Ser Ser
130 135
<210> 50
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 50
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
1 5 10 15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Thr Gln
85 90 95
Ser Phe Ile Leu Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 51
<211> 119
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 51
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Trp Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Asn Glu Lys Phe
50 55 60
Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr
65 70 75 80
Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Ser Tyr Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 52
<211> 413
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 52
Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro
1 5 10 15
Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His
20 25 30
Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro
35 40 45
Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu
50 55 60
Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg
65 70 75 80
Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser
85 90 95
Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg
100 105 110
Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu
115 120 125
Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu
130 135 140
Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp
145 150 155 160
Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys
165 170 175
Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val
180 185 190
Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn
195 200 205
Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val
210 215 220
Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala
225 230 235 240
Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn
245 250 255
Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu
260 265 270
Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn
275 280 285
Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser
290 295 300
Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser
305 310 315 320
Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly
325 330 335
Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr
340 345 350
Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln
355 360 365
Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His
370 375 380
Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro
385 390 395 400
Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly
405 410
<210> 53
<211> 115
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 53
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Leu Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Tyr Trp Pro Met Asp Ile Trp Gly Gln Gly Thr Leu Val Thr
100 105 110
Val Ser Ser
115
<210> 54
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 54
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
1 5 10 15
Glu Arg Ala Thr Leu Ser Cys Arg Gly Gly Gln Ser Val Ser Ser Ser
20 25 30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
35 40 45
Met Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65 70 75 80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gln Ser Trp Pro
85 90 95
Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 55
<211> 140
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 55
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
1 5 10 15
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln
20 25 30
Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
35 40 45
Lys Thr Tyr Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Thr Gly Leu
50 55 60
Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Thr Thr Tyr
65 70 75 80
Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser
85 90 95
Gln Asn Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr
100 105 110
Ala Met Tyr Tyr Cys Val Arg Pro Gln Ser Gly Thr Ser Phe Ala Tyr
115 120 125
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala
130 135 140
<210> 56
<211> 131
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 56
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
1 5 10 15
Val His Ser Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val
20 25 30
Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val
35 40 45
Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly
50 55 60
Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly
65 70 75 80
Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu
85 90 95
Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln
100 105 110
Gln Asn Asn Gly Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu
115 120 125
Ile Ile Arg
130
<210> 57
<211> 120
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 57
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Lys
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Phe
20 25 30
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ala Thr Ile Ser Tyr Asp Gly Ser Asn Ala Phe Tyr Ala Asp Ser Val
50 55 60
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Ser Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Lys Ala Gly Asp Gly Gly Tyr Asp Val Phe Asp Ser Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 58
<211> 111
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 58
Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
20 25 30
Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
85 90 95
Leu Gln Thr Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
100 105 110
<210> 59
<211> 1473
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 59
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatatcc agatgaccca gagcccaagc tccctgtccg cctctgtggg cgacagggtg 120
accatcacat gccgcgccag ccagacaatc tggtcctacc tgaactggta tcagcagaga 180
cccggcaagg cccctaatct gctgatctac gcagcatcta gcctgcagtc tggagtgccc 240
tcccggttct ctggaagagg atccggaacc gacttcaccc tgacaatctc ctctctgcag 300
gccgaggact tcgccacata ctattgccag cagagctatt ccatccctca gacctttggc 360
cagggcacaa agctggagat caagggcggc ggcggctctg gaggaggagg aagcggagga 420
ggaggatccc aggtgcagct gcagcagagc ggaccaggac tggtgaagcc ctcccagacc 480
ctgtctctga catgtgccat cagcggcgat tccgtgagct ccaacagcgc cgcctggaat 540
tggatccggc agtctcccag cagaggactg gagtggctgg gaaggaccta ctatcgctcc 600
aagtggtaca acgattatgc cgtgtctgtg aagagccgga tcaccatcaa ccctgacaca 660
tctaagaatc agttcagcct gcagctgaat tccgtgaccc cagaggacac agccgtgtac 720
tattgtgcaa gggaggtgac cggcgacctg gaggatgcct ttgacatctg gggccagggc 780
accatggtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc 840
accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc 900
gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc 960
gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga 1020
aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag 1080
gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg 1140
aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac 1200
gagctcaatc taggacgaag agaggagtac gatgttttgg acaagaggcg tggccgggac 1260
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg 1320
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg 1380
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac 1440
gcccttcaca tgcaggccct gccccctcgc taa 1473
<210> 60
<211> 1446
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 60
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc 120
accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag 180
cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc 240
tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa 300
ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga 360
caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg 480
ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc 540
cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc 600
tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact 660
ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg 720
catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg 780
acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg 840
cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc 900
gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca 960
ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa 1020
ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca 1080
gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc 1140
gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag 1200
tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg 1260
aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac 1320
agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag 1380
ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct 1440
cgctaa 1446
<210> 61
<211> 1467
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 61
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaa 1467
<210> 62
<211> 3533
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 62
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc 120
accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa 180
ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca 240
tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag 300
caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga 360
ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc 480
ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt 540
cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca 600
tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa 660
gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa 720
cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc 780
gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg 840
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg 900
agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg 960
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg 1020
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt 1080
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg 1140
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta 1200
ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg 1260
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag 1320
atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac 1380
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg 1440
caggccctgc cccctcgcta atctagaggc gcgcccctct ccctcccccc cccctaacgt 1500
tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac 1560
catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag 1620
cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa 1680
ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag 1740
gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga 1800
tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag 1860
agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc 1920
ccattgtatg ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag 1980
gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg 2040
atgataatat ggccacaacc catatgatgg ccttaccagt gaccgccttg ctcctgccgc 2100
tggccttgct gctccacgcc gccaggccgg acatcgtgat gacccagtcc ccctccagcc 2160
tgacagtgac agccggcgag aaggtgacaa tgatctgtaa gtccagccag agcctgctga 2220
acagcggcga ccagaagaac tacctgacct ggtaccagca gaagcctggc cagcccccca 2280
agctgctgat cttctgggcc agcacaaggg agagcggcgt gcccgacaga ttcacaggca 2340
gcggcagcgg caccgacttc acactgacca tttcctccgt gcaggccgag gacctcgccg 2400
tgtactactg ccagaacgac tactcctacc ccctgacatt cggcgccggc accaaactgg 2460
agctgaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga tctcaggtgc 2520
agctccagca gtccgatgcc gagctggtga agcccggaag cagcgtcaag atcagctgta 2580
aggcctccgg ctacaccttc acagaccacg ccatccactg ggtgaagcag aagcccgagc 2640
agggcctgga gtggatcggc cactttagcc ccggaaacac cgacatcaag tacaacgaca 2700
agttcaaggg caaggccacc ctgaccgtgg acaggagcag cagcaccgcc tacatgcagc 2760
tgaacagcct gacaagcgag gacagcgccg tgtacttctg caagacctcc accttcttct 2820
tcgactactg gggccaggga accaccctga cagtgtccag caccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc 3060
tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac 3120
cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag 3180
gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg 3240
gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg 3300
acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg 3360
aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga 3420
tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag 3480
ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa 3533
<210> 63
<211> 3533
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 63
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatatcc agatgaccca gagcccgagc agcctgagcg cgagcgtggg tgatcgcgtg 120
accattacct gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa 180
ccgggtaaag cgccgaaact gttaatttat catacatcaa gattacactc aggcgtgccg 240
tcgcgtttta gcggctcggg ttcgggcacc gattttaccc tgaccatctc gagcttgcag 300
ccggaggact tcgccaccta ctattgccaa cagggtaata cgcttccgta cacgttcggt 360
cagggcacca aagtggagat caaaggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aggtgcagct ggtggagtct gggggaggct tggtacagcc tggggggtcc 480
ctgagactct cctgtgcagc ctctggagtg tccctgcctg attatggcgt gtcctgggtc 540
cgccaggctc cagggaaggg gctggagtgg gtttcagtga tctggggcag cgagacaacc 600
tactacaaca gcgccctgaa gtcccgattc accatctcca gagacaatgc caagaactca 660
ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaag 720
cactactact acggcggcag ctacgctatg gactactggg gccaaggaac cctggtcacc 780
gtgtcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg 840
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg 900
agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg 960
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg 1020
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt 1080
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg 1140
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta 1200
ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg 1260
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag 1320
atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac 1380
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg 1440
caggccctgc cccctcgcta atctagaggc gcgcccctct ccctcccccc cccctaacgt 1500
tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac 1560
catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag 1620
cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa 1680
ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag 1740
gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga 1800
tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag 1860
agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc 1920
ccattgtatg ggatctgatc tggggcctcg gtacacatgc tttacatgtg tttagtcgag 1980
gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg 2040
atgataatat ggccacaacc catatgatgg ccttaccagt gaccgccttg ctcctgccgc 2100
tggccttgct gctccacgcc gccaggccgg acatcgtgat gacccagtcc ccctccagcc 2160
tgacagtgac agccggcgag aaggtgacaa tgatctgtaa gtccagccag agcctgctga 2220
acagcggcga ccagaagaac tacctgacct ggtaccagca gaagcctggc cagcccccca 2280
agctgctgat cttctgggcc agcacaaggg agagcggcgt gcccgacaga ttcacaggca 2340
gcggcagcgg caccgacttc acactgacca tttcctccgt gcaggccgag gacctcgccg 2400
tgtactactg ccagaacgac tactcctacc ccctgacatt cggcgccggc accaaactgg 2460
agctgaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga tctcaggtgc 2520
agctccagca gtccgatgcc gagctggtga agcccggaag cagcgtcaag atcagctgta 2580
aggcctccgg ctacaccttc acagaccacg ccatccactg ggtgaagcag aagcccgagc 2640
agggcctgga gtggatcggc cactttagcc ccggaaacac cgacatcaag tacaacgaca 2700
agttcaaggg caaggccacc ctgaccgtgg acaggagcag cagcaccgcc tacatgcagc 2760
tgaacagcct gacaagcgag gacagcgccg tgtacttctg caagacctcc accttcttct 2820
tcgactactg gggccaggga accaccctga cagtgtccag caccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc 3060
tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac 3120
cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag 3180
gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg 3240
gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg 3300
acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg 3360
aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga 3420
tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag 3480
ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa 3533
<210> 64
<211> 3545
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 64
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatatcc agatgaccca gagcccaagc tccctgtccg cctctgtggg cgacagggtg 120
accatcacat gccgcgccag ccagacaatc tggtcctacc tgaactggta tcagcagaga 180
cccggcaagg cccctaatct gctgatctac gcagcatcta gcctgcagtc tggagtgccc 240
tcccggttct ctggaagagg atccggaacc gacttcaccc tgacaatctc ctctctgcag 300
gccgaggact tcgccacata ctattgccag cagagctatt ccatccctca gacctttggc 360
cagggcacaa agctggagat caagggcggc ggcggctctg gaggaggagg aagcggagga 420
ggaggatccc aggtgcagct gcagcagagc ggaccaggac tggtgaagcc ctcccagacc 480
ctgtctctga catgtgccat cagcggcgat tccgtgagct ccaacagcgc cgcctggaat 540
tggatccggc agtctcccag cagaggactg gagtggctgg gaaggaccta ctatcgctcc 600
aagtggtaca acgattatgc cgtgtctgtg aagagccgga tcaccatcaa ccctgacaca 660
tctaagaatc agttcagcct gcagctgaat tccgtgaccc cagaggacac agccgtgtac 720
tattgtgcaa gggaggtgac cggcgacctg gaggatgcct ttgacatctg gggccagggc 780
accatggtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc 840
accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc 900
gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc 960
gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga 1020
aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag 1080
gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg 1140
aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac 1200
gagctcaatc taggacgaag agaggagtac gatgttttgg acaagaggcg tggccgggac 1260
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg 1320
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg 1380
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac 1440
gcccttcaca tgcaggccct gccccctcgc taatctagag gcgcgcccct ctccctcccc 1500
cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat 1560
gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt 1620
cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt 1680
gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc 1740
gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc 1800
acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat 1860
agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc 1920
ccagaaggta ccccattgta tgggatctga tctggggcct cggtacacat gctttacatg 1980
tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct 2040
ttgaaaaaca cgatgataat atggccacaa cccatatgat ggccttacca gtgaccgcct 2100
tgctcctgcc gctggccttg ctgctccacg ccgccaggcc ggacatcgtg atgacccagt 2160
ccccctccag cctgacagtg acagccggcg agaaggtgac aatgatctgt aagtccagcc 2220
agagcctgct gaacagcggc gaccagaaga actacctgac ctggtaccag cagaagcctg 2280
gccagccccc caagctgctg atcttctggg ccagcacaag ggagagcggc gtgcccgaca 2340
gattcacagg cagcggcagc ggcaccgact tcacactgac catttcctcc gtgcaggccg 2400
aggacctcgc cgtgtactac tgccagaacg actactccta ccccctgaca ttcggcgccg 2460
gcaccaaact ggagctgaag ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg 2520
gatctcaggt gcagctccag cagtccgatg ccgagctggt gaagcccgga agcagcgtca 2580
agatcagctg taaggcctcc ggctacacct tcacagacca cgccatccac tgggtgaagc 2640
agaagcccga gcagggcctg gagtggatcg gccactttag ccccggaaac accgacatca 2700
agtacaacga caagttcaag ggcaaggcca ccctgaccgt ggacaggagc agcagcaccg 2760
cctacatgca gctgaacagc ctgacaagcg aggacagcgc cgtgtacttc tgcaagacct 2820
ccaccttctt cttcgactac tggggccagg gaaccaccct gacagtgtcc agcaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3120
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3180
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3240
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3300
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3360
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3420
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3480
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3540
gctaa 3545
<210> 65
<211> 3518
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 65
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc 120
accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag 180
cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc 240
tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa 300
ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga 360
caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg 480
ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc 540
cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc 600
tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact 660
ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg 720
catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg 780
acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg 840
cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc 900
gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca 960
ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa 1020
ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca 1080
gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc 1140
gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag 1200
tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg 1260
aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac 1320
agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag 1380
ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct 1440
cgctaatcta gaggcgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg 1500
cttggaataa ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt 1560
tggcaatgtg agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct 1620
ttcccctctc gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct 1680
ggaagcttct tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc 1740
acctggcgac aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc 1800
ggcacaaccc cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc 1860
ctcaagcgta ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc 1920
tgatctgggg cctcggtaca catgctttac atgtgtttag tcgaggttaa aaaaacgtct 1980
aggccccccg aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca 2040
caacccatat gatggcctta ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc 2100
acgccgccag gccggacatc gtgatgaccc agtccccctc cagcctgaca gtgacagccg 2160
gcgagaaggt gacaatgatc tgtaagtcca gccagagcct gctgaacagc ggcgaccaga 2220
agaactacct gacctggtac cagcagaagc ctggccagcc ccccaagctg ctgatcttct 2280
gggccagcac aagggagagc ggcgtgcccg acagattcac aggcagcggc agcggcaccg 2340
acttcacact gaccatttcc tccgtgcagg ccgaggacct cgccgtgtac tactgccaga 2400
acgactactc ctaccccctg acattcggcg ccggcaccaa actggagctg aagggtggcg 2460
gtggctcggg cggtggtggg tcgggtggcg gcggatctca ggtgcagctc cagcagtccg 2520
atgccgagct ggtgaagccc ggaagcagcg tcaagatcag ctgtaaggcc tccggctaca 2580
ccttcacaga ccacgccatc cactgggtga agcagaagcc cgagcagggc ctggagtgga 2640
tcggccactt tagccccgga aacaccgaca tcaagtacaa cgacaagttc aagggcaagg 2700
ccaccctgac cgtggacagg agcagcagca ccgcctacat gcagctgaac agcctgacaa 2760
gcgaggacag cgccgtgtac ttctgcaaga cctccacctt cttcttcgac tactggggcc 2820
agggaaccac cctgacagtg tccagcacca cgacgccagc gccgcgacca ccaacaccgg 2880
cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg 2940
ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct 3000
tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgcaaacggg 3060
gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta caaactactc 3120
aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga 3180
gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct 3240
ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag aggcgtggcc 3300
gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg 3360
aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc 3420
ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct 3480
acgacgccct tcacatgcag gccctgcccc ctcgctaa 3518
<210> 66
<211> 2994
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 66
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc 120
accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa 180
ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca 240
tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag 300
caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga 360
ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc 480
ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt 540
cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca 600
tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa 660
gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa 720
cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc 780
gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg 840
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg 900
agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg 960
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg 1020
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt 1080
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg 1140
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta 1200
ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg 1260
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag 1320
atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac 1380
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg 1440
caggccctgc cccctcgctc tagagccacg aacttctctc tgttaaagca agcaggagac 1500
gtggaagaaa accccggtcc tcatatgatg gccttaccag tgaccgcctt gctcctgccg 1560
ctggccttgc tgctccacgc cgccaggccg gacatcgtga tgacccagtc cccctccagc 1620
ctgacagtga cagccggcga gaaggtgaca atgatctgta agtccagcca gagcctgctg 1680
aacagcggcg accagaagaa ctacctgacc tggtaccagc agaagcctgg ccagcccccc 1740
aagctgctga tcttctgggc cagcacaagg gagagcggcg tgcccgacag attcacaggc 1800
agcggcagcg gcaccgactt cacactgacc atttcctccg tgcaggccga ggacctcgcc 1860
gtgtactact gccagaacga ctactcctac cccctgacat tcggcgccgg caccaaactg 1920
gagctgaagg gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctcaggtg 1980
cagctccagc agtccgatgc cgagctggtg aagcccggaa gcagcgtcaa gatcagctgt 2040
aaggcctccg gctacacctt cacagaccac gccatccact gggtgaagca gaagcccgag 2100
cagggcctgg agtggatcgg ccactttagc cccggaaaca ccgacatcaa gtacaacgac 2160
aagttcaagg gcaaggccac cctgaccgtg gacaggagca gcagcaccgc ctacatgcag 2220
ctgaacagcc tgacaagcga ggacagcgcc gtgtacttct gcaagacctc caccttcttc 2280
ttcgactact ggggccaggg aaccaccctg acagtgtcca gcaccacgac gccagcgccg 2340
cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg 2400
tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc 2460
tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc 2520
ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga 2580
ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa 2640
ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag 2700
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg 2760
gacaagaggc gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag 2820
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg 2880
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca 2940
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 2994
<210> 67
<211> 2994
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 67
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatatcc agatgaccca gagcccgagc agcctgagcg cgagcgtggg tgatcgcgtg 120
accattacct gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa 180
ccgggtaaag cgccgaaact gttaatttat catacatcaa gattacactc aggcgtgccg 240
tcgcgtttta gcggctcggg ttcgggcacc gattttaccc tgaccatctc gagcttgcag 300
ccggaggact tcgccaccta ctattgccaa cagggtaata cgcttccgta cacgttcggt 360
cagggcacca aagtggagat caaaggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aggtgcagct ggtggagtct gggggaggct tggtacagcc tggggggtcc 480
ctgagactct cctgtgcagc ctctggagtg tccctgcctg attatggcgt gtcctgggtc 540
cgccaggctc cagggaaggg gctggagtgg gtttcagtga tctggggcag cgagacaacc 600
tactacaaca gcgccctgaa gtcccgattc accatctcca gagacaatgc caagaactca 660
ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaag 720
cactactact acggcggcag ctacgctatg gactactggg gccaaggaac cctggtcacc 780
gtgtcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg 840
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg 900
agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg 960
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg 1020
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt 1080
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg 1140
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta 1200
ggacgaagag aggagtacga tgttttggac aagaggcgtg gccgggaccc tgagatgggg 1260
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag 1320
atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac 1380
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg 1440
caggccctgc cccctcgctc tagagccacg aacttctctc tgttaaagca agcaggagac 1500
gtggaagaaa accccggtcc tcatatgatg gccttaccag tgaccgcctt gctcctgccg 1560
ctggccttgc tgctccacgc cgccaggccg gacatcgtga tgacccagtc cccctccagc 1620
ctgacagtga cagccggcga gaaggtgaca atgatctgta agtccagcca gagcctgctg 1680
aacagcggcg accagaagaa ctacctgacc tggtaccagc agaagcctgg ccagcccccc 1740
aagctgctga tcttctgggc cagcacaagg gagagcggcg tgcccgacag attcacaggc 1800
agcggcagcg gcaccgactt cacactgacc atttcctccg tgcaggccga ggacctcgcc 1860
gtgtactact gccagaacga ctactcctac cccctgacat tcggcgccgg caccaaactg 1920
gagctgaagg gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctcaggtg 1980
cagctccagc agtccgatgc cgagctggtg aagcccggaa gcagcgtcaa gatcagctgt 2040
aaggcctccg gctacacctt cacagaccac gccatccact gggtgaagca gaagcccgag 2100
cagggcctgg agtggatcgg ccactttagc cccggaaaca ccgacatcaa gtacaacgac 2160
aagttcaagg gcaaggccac cctgaccgtg gacaggagca gcagcaccgc ctacatgcag 2220
ctgaacagcc tgacaagcga ggacagcgcc gtgtacttct gcaagacctc caccttcttc 2280
ttcgactact ggggccaggg aaccaccctg acagtgtcca gcaccacgac gccagcgccg 2340
cgaccaccaa caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg 2400
tgccggccag cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc 2460
tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc 2520
ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga 2580
ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa 2640
ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag 2700
ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg 2760
gacaagaggc gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag 2820
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg 2880
atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca 2940
gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 2994
<210> 68
<211> 3009
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 68
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatatcc agatgaccca gagcccaagc tccctgtccg cctctgtggg cgacagggtg 120
accatcacat gccgcgccag ccagacaatc tggtcctacc tgaactggta tcagcagaga 180
cccggcaagg cccctaatct gctgatctac gcagcatcta gcctgcagtc tggagtgccc 240
tcccggttct ctggaagagg atccggaacc gacttcaccc tgacaatctc ctctctgcag 300
gccgaggact tcgccacata ctattgccag cagagctatt ccatccctca gacctttggc 360
cagggcacaa agctggagat caagggcggc ggcggctctg gaggaggagg aagcggagga 420
ggaggatccc aggtgcagct gcagcagagc ggaccaggac tggtgaagcc ctcccagacc 480
ctgtctctga catgtgccat cagcggcgat tccgtgagct ccaacagcgc cgcctggaat 540
tggatccggc agtctcccag cagaggactg gagtggctgg gaaggaccta ctatcgctcc 600
aagtggtaca acgattatgc cgtgtctgtg aagagccgga tcaccatcaa ccctgacaca 660
tctaagaatc agttcagcct gcagctgaat tccgtgaccc cagaggacac agccgtgtac 720
tattgtgcaa gggaggtgac cggcgacctg gaggatgcct ttgacatctg gggccagggc 780
accatggtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc 840
accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc 900
gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccttggcc 960
gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga 1020
aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag 1080
gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg 1140
aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac 1200
gagctcaatc taggacgaag agaggagtac gatgttttgg acaagaggcg tggccgggac 1260
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg 1320
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg 1380
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac 1440
gcccttcaca tgcaggccct gccccctcgc taatctagag ccacgaactt ctctctgtta 1500
aagcaagcag gagacgtgga agaaaacccc ggtcctcata tgatggcctt accagtgacc 1560
gccttgctcc tgccgctggc cttgctgctc cacgccgcca ggccggacat cgtgatgacc 1620
cagtccccct ccagcctgac agtgacagcc ggcgagaagg tgacaatgat ctgtaagtcc 1680
agccagagcc tgctgaacag cggcgaccag aagaactacc tgacctggta ccagcagaag 1740
cctggccagc cccccaagct gctgatcttc tgggccagca caagggagag cggcgtgccc 1800
gacagattca caggcagcgg cagcggcacc gacttcacac tgaccatttc ctccgtgcag 1860
gccgaggacc tcgccgtgta ctactgccag aacgactact cctaccccct gacattcggc 1920
gccggcacca aactggagct gaagggtggc ggtggctcgg gcggtggtgg gtcgggtggc 1980
ggcggatctc aggtgcagct ccagcagtcc gatgccgagc tggtgaagcc cggaagcagc 2040
gtcaagatca gctgtaaggc ctccggctac accttcacag accacgccat ccactgggtg 2100
aagcagaagc ccgagcaggg cctggagtgg atcggccact ttagccccgg aaacaccgac 2160
atcaagtaca acgacaagtt caagggcaag gccaccctga ccgtggacag gagcagcagc 2220
accgcctaca tgcagctgaa cagcctgaca agcgaggaca gcgccgtgta cttctgcaag 2280
acctccacct tcttcttcga ctactggggc cagggaacca ccctgacagt gtccagcacc 2340
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc 2400
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac 2460
ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg 2520
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa 2580
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt 2640
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc 2700
cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag 2760
gagtacgatg ttttggacaa gaggcgtggc cgggaccctg agatgggggg aaagccgaga 2820
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc 2880
tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac 2940
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc 3000
cctcgctaa 3009
<210> 69
<211> 2982
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 69
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agctcaccca gtccccgagc tcgctgtccg cctccgtggg agatcgggtc 120
accatcacgt gccgcgccag ccagtcgatt tcctcctacc tgaactggta ccaacagaag 180
cccggaaaag ccccgaagct tctcatctac gccgcctcga gcctgcagtc aggagtgccc 240
tcacggttct ccggctccgg ttccggtact gatttcaccc tgaccatttc ctccctgcaa 300
ccggaggact tcgctactta ctactgccag cagtcgtact ccacccccta cactttcgga 360
caaggcacca aggtcgaaat caagggtggc ggtggctcgg gcggtggtgg gtcgggtggc 420
ggcggatctg aagtgcaatt ggtggaatca gggggaggac ttgtgcagcc tggaggatcg 480
ctgagactgt catgtgccgt gtccggcttt gccctgtcca accacgggat gtcctgggtc 540
cgccgcgcgc ctggaaaggg cctcgaatgg gtgtcgggta ttgtgtacag cggtagcacc 600
tactatgccg catccgtgaa ggggagattc accatcagcc gggacaactc caggaacact 660
ctgtacctcc aaatgaattc gctgaggcca gaggacactg ccatctacta ctgctccgcg 720
catggcggag agtccgacgt ctggggacag gggaccaccg tgaccgtgtc tagcaccacg 780
acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg 840
cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc 900
gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca 960
ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa 1020
ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca 1080
gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc 1140
gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag 1200
tacgatgttt tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg 1260
aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac 1320
agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag 1380
ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct 1440
cgctaatcta gagccacgaa cttctctctg ttaaagcaag caggagacgt ggaagaaaac 1500
cccggtcctc atatgatggc cttaccagtg accgccttgc tcctgccgct ggccttgctg 1560
ctccacgccg ccaggccgga catcgtgatg acccagtccc cctccagcct gacagtgaca 1620
gccggcgaga aggtgacaat gatctgtaag tccagccaga gcctgctgaa cagcggcgac 1680
cagaagaact acctgacctg gtaccagcag aagcctggcc agccccccaa gctgctgatc 1740
ttctgggcca gcacaaggga gagcggcgtg cccgacagat tcacaggcag cggcagcggc 1800
accgacttca cactgaccat ttcctccgtg caggccgagg acctcgccgt gtactactgc 1860
cagaacgact actcctaccc cctgacattc ggcgccggca ccaaactgga gctgaagggt 1920
ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctcaggtgca gctccagcag 1980
tccgatgccg agctggtgaa gcccggaagc agcgtcaaga tcagctgtaa ggcctccggc 2040
tacaccttca cagaccacgc catccactgg gtgaagcaga agcccgagca gggcctggag 2100
tggatcggcc actttagccc cggaaacacc gacatcaagt acaacgacaa gttcaagggc 2160
aaggccaccc tgaccgtgga caggagcagc agcaccgcct acatgcagct gaacagcctg 2220
acaagcgagg acagcgccgt gtacttctgc aagacctcca ccttcttctt cgactactgg 2280
ggccagggaa ccaccctgac agtgtccagc accacgacgc cagcgccgcg accaccaaca 2340
ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg 2400
gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg 2460
cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa 2520
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact 2580
actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa 2640
ctgagagtga agttcagcag gagcgcagac gcccccgcgt acaagcaggg ccagaaccag 2700
ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagaggcgt 2760
ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac 2820
aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag 2880
cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac 2940
acctacgacg cccttcacat gcaggccctg ccccctcgct aa 2982
<210> 70
<211> 244
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 70
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser
<210> 71
<211> 116
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 71
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
20 25 30
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
35 40 45
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
100 105 110
Thr Val Ser Ser
115
<210> 72
<211> 113
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 72
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys
<210> 73
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 73
Gln Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr
1 5 10
<210> 74
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 75
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 75
Gln Asn Asp Tyr Ser Tyr Pro Leu Thr
1 5
<210> 76
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 76
Gly Tyr Thr Phe Thr Asp His Ala
1 5
<210> 77
<211> 8
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 77
Phe Ser Pro Gly Asn Thr Asp Ile
1 5
<210> 78
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 78
Lys Thr Ser Thr Phe Phe Phe Asp Tyr
1 5
<210> 79
<211> 246
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 79
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser
245
<210> 80
<211> 117
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 80
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val
35 40 45
Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser
65 70 75 80
Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr
85 90 95
Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
100 105 110
Leu Thr Val Ser Ser
115
<210> 81
<211> 114
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 81
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala
<210> 82
<211> 16
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 82
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Phe Phe
1 5 10 15
<210> 83
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 83
Gln Met Ser Asn Leu Ala Ser
1 5
<210> 84
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 84
Ala Gln Asn Leu Glu Leu Pro Pro Thr
1 5
<210> 85
<211> 5
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 85
Asn Tyr Trp Met Asn
1 5
<210> 86
<211> 19
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 86
Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu Ser
1 5 10 15
Val Lys Gly
<210> 87
<211> 6
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 87
His Tyr Tyr Phe Asp Tyr
1 5
<210> 88
<211> 4
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 88
Gly Ser Thr Ala
1
<210> 89
<211> 97
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 89
Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln
1 5 10 15
Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Ala
20 25 30
Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val
35 40 45
Pro Cys Val Pro Glu Gln Thr Glu Ala Ala Thr Ile Val Phe Pro Ser
50 55 60
Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro
65 70 75 80
Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro
85 90 95
Leu
<210> 90
<211> 17
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 90
Cys Ser Arg Ala Ala Arg Gly Thr Ile Asp Gly His Cys Ser Trp Pro
1 5 10 15
Leu
<210> 91
<211> 21
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 91
Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp
1 5 10 15
Val Leu Ala Val Ile
20
<210> 92
<211> 18
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 92
Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr Leu Ser Pro
1 5 10 15
Ser Thr
<210> 93
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 93
Cys Ser Arg Ala Ala Arg Gly Thr Ile
1 5
<210> 94
<211> 80
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 94
Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val
1 5 10 15
Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu
20 25 30
Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr
35 40 45
Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg
50 55 60
Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu
65 70 75 80
<210> 95
<211> 80
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 95
Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val
1 5 10 15
Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu
20 25 30
Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr
35 40 45
Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg
50 55 60
Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu
65 70 75 80
<210> 96
<211> 196
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 96
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 97
<211> 196
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 97
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Lys Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 98
<211> 196
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 98
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 99
<211> 323
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 99
Met Arg Trp Ala Leu Val Val Leu Leu Ala Phe Leu Ser Pro Ala Ser
1 5 10 15
Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Gln
20 25 30
Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Thr Asn Thr
35 40 45
Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg
50 55 60
Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp Val Leu Glu Ser Gly
65 70 75 80
Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser Trp
85 90 95
Ile Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr
100 105 110
Cys Ala Thr Trp Asp Arg Pro Arg Leu Lys Lys Leu Phe Gly Ser Gly
115 120 125
Thr Thr Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro
130 135 140
Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys
145 150 155 160
Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile
165 170 175
Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln
180 185 190
Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp
195 200 205
Leu Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val
210 215 220
Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro
225 230 235 240
Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser
245 250 255
Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp Asn Trp Ser
260 265 270
Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala
275 280 285
Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala
290 295 300
Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly
305 310 315 320
Glu Lys Ser
<210> 100
<211> 127
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 100
Met Asn Val Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Thr
1 5 10 15
Gly Gly Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser
20 25 30
Ala Ser Leu Glu Glu Ile Val Thr Ile Thr Cys Lys Ala Ser Gln Ala
35 40 45
Ile Asp Ala Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro
50 55 60
Gln Leu Leu Ile Tyr Asp Ala Thr Ser Leu Ala Asp Gly Val Pro Ser
65 70 75 80
Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser
85 90 95
Arg Pro Gln Val Asp Asp Ser Gly Ile Tyr Tyr Cys Leu Gln Ser Tyr
100 105 110
Ser Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
115 120 125
<210> 101
<211> 184
<212> PRT
<213> 智人（Homo sapiens）
<400> 101
Met Ala Pro Leu Leu Pro Ile Arg Thr Leu Pro Leu Ile Leu Ile Leu
1 5 10 15
Leu Ala Leu Leu Ser Pro Gly Ala Ala Asp Phe Asn Ile Ser Ser Leu
20 25 30
Ser Gly Leu Leu Ser Pro Ala Leu Thr Glu Ser Leu Leu Val Ala Leu
35 40 45
Pro Pro Cys His Leu Thr Gly Gly Asn Ala Thr Leu Met Val Arg Arg
50 55 60
Ala Asn Asp Ser Lys Val Val Thr Ser Ser Phe Val Val Pro Pro Cys
65 70 75 80
Arg Gly Arg Arg Glu Leu Val Ser Val Val Asp Ser Gly Ala Gly Phe
85 90 95
Thr Val Thr Arg Leu Ser Ala Tyr Gln Val Thr Asn Leu Val Pro Gly
100 105 110
Thr Lys Phe Tyr Ile Ser Tyr Leu Val Lys Lys Gly Thr Ala Thr Glu
115 120 125
Ser Ser Arg Glu Ile Pro Met Ser Thr Leu Pro Arg Arg Asn Met Glu
130 135 140
Ser Ile Gly Leu Gly Met Ala Arg Thr Gly Gly Met Val Val Ile Thr
145 150 155 160
Val Leu Leu Ser Val Ala Met Phe Leu Leu Val Leu Gly Phe Ile Ile
165 170 175
Ala Leu Ala Leu Gly Ser Arg Lys
180
<210> 102
<211> 909
<212> PRT
<213> 智人（Homo sapiens）
<400> 102
Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu
1 5 10 15
Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser
20 25 30
Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly
35 40 45
Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His
50 55 60
Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile
65 70 75 80
Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu
85 90 95
Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr
100 105 110
Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr
115 120 125
Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu
130 135 140
Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala
145 150 155 160
Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg
165 170 175
Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn
180 185 190
Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu
195 200 205
Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn
210 215 220
Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg
225 230 235 240
Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn
245 250 255
Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys
260 265 270
Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp
275 280 285
Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln
290 295 300
Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro
305 310 315 320
Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp
325 330 335
His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu
340 345 350
Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser
355 360 365
Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr
370 375 380
Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu
385 390 395 400
Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro
405 410 415
Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val
420 425 430
Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn
435 440 445
Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys
450 455 460
Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr
465 470 475 480
Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr
485 490 495
Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His
500 505 510
Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr
515 520 525
His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala
530 535 540
Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly
545 550 555 560
Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg
565 570 575
Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro
580 585 590
Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln
595 600 605
Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp
610 615 620
Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp
625 630 635 640
Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly
645 650 655
Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn
660 665 670
Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp
675 680 685
Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala
690 695 700
Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu
705 710 715 720
Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg
725 730 735
Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val
740 745 750
Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu
755 760 765
Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro
770 775 780
Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile
785 790 795 800
Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln
805 810 815
Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro
820 825 830
Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr
835 840 845
Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala
850 855 860
Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp
865 870 875 880
Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro
885 890 895
His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys
900 905
<210> 103
<211> 553
<212> PRT
<213> 智人（Homo sapiens）
<400> 103
Met Val Gln Arg Leu Trp Val Ser Arg Leu Leu Arg His Arg Lys Ala
1 5 10 15
Gln Leu Leu Leu Val Asn Leu Leu Thr Phe Gly Leu Glu Val Cys Leu
20 25 30
Ala Ala Gly Ile Thr Tyr Val Pro Pro Leu Leu Leu Glu Val Gly Val
35 40 45
Glu Glu Lys Phe Met Thr Met Val Leu Gly Ile Gly Pro Val Leu Gly
50 55 60
Leu Val Cys Val Pro Leu Leu Gly Ser Ala Ser Asp His Trp Arg Gly
65 70 75 80
Arg Tyr Gly Arg Arg Arg Pro Phe Ile Trp Ala Leu Ser Leu Gly Ile
85 90 95
Leu Leu Ser Leu Phe Leu Ile Pro Arg Ala Gly Trp Leu Ala Gly Leu
100 105 110
Leu Cys Pro Asp Pro Arg Pro Leu Glu Leu Ala Leu Leu Ile Leu Gly
115 120 125
Val Gly Leu Leu Asp Phe Cys Gly Gln Val Cys Phe Thr Pro Leu Glu
130 135 140
Ala Leu Leu Ser Asp Leu Phe Arg Asp Pro Asp His Cys Arg Gln Ala
145 150 155 160
Tyr Ser Val Tyr Ala Phe Met Ile Ser Leu Gly Gly Cys Leu Gly Tyr
165 170 175
Leu Leu Pro Ala Ile Asp Trp Asp Thr Ser Ala Leu Ala Pro Tyr Leu
180 185 190
Gly Thr Gln Glu Glu Cys Leu Phe Gly Leu Leu Thr Leu Ile Phe Leu
195 200 205
Thr Cys Val Ala Ala Thr Leu Leu Val Ala Glu Glu Ala Ala Leu Gly
210 215 220
Pro Thr Glu Pro Ala Glu Gly Leu Ser Ala Pro Ser Leu Ser Pro His
225 230 235 240
Cys Cys Pro Cys Arg Ala Arg Leu Ala Phe Arg Asn Leu Gly Ala Leu
245 250 255
Leu Pro Arg Leu His Gln Leu Cys Cys Arg Met Pro Arg Thr Leu Arg
260 265 270
Arg Leu Phe Val Ala Glu Leu Cys Ser Trp Met Ala Leu Met Thr Phe
275 280 285
Thr Leu Phe Tyr Thr Asp Phe Val Gly Glu Gly Leu Tyr Gln Gly Val
290 295 300
Pro Arg Ala Glu Pro Gly Thr Glu Ala Arg Arg His Tyr Asp Glu Gly
305 310 315 320
Val Arg Met Gly Ser Leu Gly Leu Phe Leu Gln Cys Ala Ile Ser Leu
325 330 335
Val Phe Ser Leu Val Met Asp Arg Leu Val Gln Arg Phe Gly Thr Arg
340 345 350
Ala Val Tyr Leu Ala Ser Val Ala Ala Phe Pro Val Ala Ala Gly Ala
355 360 365
Thr Cys Leu Ser His Ser Val Ala Val Val Thr Ala Ser Ala Ala Leu
370 375 380
Thr Gly Phe Thr Phe Ser Ala Leu Gln Ile Leu Pro Tyr Thr Leu Ala
385 390 395 400
Ser Leu Tyr His Arg Glu Lys Gln Val Phe Leu Pro Lys Tyr Arg Gly
405 410 415
Asp Thr Gly Gly Ala Ser Ser Glu Asp Ser Leu Met Thr Ser Phe Leu
420 425 430
Pro Gly Pro Lys Pro Gly Ala Pro Phe Pro Asn Gly His Val Gly Ala
435 440 445
Gly Gly Ser Gly Leu Leu Pro Pro Pro Pro Ala Leu Cys Gly Ala Ser
450 455 460
Ala Cys Asp Val Ser Val Arg Val Val Val Gly Glu Pro Thr Glu Ala
465 470 475 480
Arg Val Val Pro Gly Arg Gly Ile Cys Leu Asp Leu Ala Ile Leu Asp
485 490 495
Ser Ala Phe Leu Leu Ser Gln Val Ala Pro Ser Leu Phe Met Gly Ser
500 505 510
Ile Val Gln Leu Ser Gln Ser Val Thr Ala Tyr Met Val Ser Ala Ala
515 520 525
Gly Leu Gly Leu Val Ala Ile Tyr Phe Ala Thr Gln Val Val Phe Asp
530 535 540
Lys Ser Asp Leu Ala Lys Tyr Ser Ala
545 550
<210> 104
<211> 418
<212> PRT
<213> 智人（Homo sapiens）
<400> 104
Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu
1 5 10 15
Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala
20 25 30
Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser
35 40 45
Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro
50 55 60
Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu
65 70 75 80
Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser
85 90 95
Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr
100 105 110
Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly
115 120 125
Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His
130 135 140
Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn
145 150 155 160
Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu
165 170 175
Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly
180 185 190
Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys
195 200 205
Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro
210 215 220
Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu
225 230 235 240
Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser
245 250 255
Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys
260 265 270
Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala
275 280 285
His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn
290 295 300
Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe
305 310 315 320
Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln
325 330 335
His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro
340 345 350
Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp
355 360 365
Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Val Leu Lys Val Ile
370 375 380
Phe Ala Val Ala Phe Cys Leu Ile Ser Ala Val Leu Met Val Leu Leu
385 390 395 400
Phe Ile His Ile Arg Arg Gly Leu Cys Trp Gln Arg Glu Ser Tyr Gly
405 410 415
Asn Ile
<210> 105
<211> 560
<212> PRT
<213> 智人（Homo sapiens）
<400> 105
Met Lys Met Gln Lys Gly Asn Val Leu Leu Met Phe Gly Leu Leu Leu
1 5 10 15
His Leu Glu Ala Ala Thr Asn Ser Asn Glu Thr Ser Thr Ser Ala Asn
20 25 30
Thr Gly Ser Ser Val Ile Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser
35 40 45
Gly Ser Ser Val Thr Ser Ser Gly Val Ser Thr Ala Thr Ile Ser Gly
50 55 60
Ser Ser Val Thr Ser Asn Gly Val Ser Ile Val Thr Asn Ser Glu Phe
65 70 75 80
His Thr Thr Ser Ser Gly Ile Ser Thr Ala Thr Asn Ser Glu Phe Ser
85 90 95
Thr Val Ser Ser Gly Ile Ser Ile Ala Thr Asn Ser Glu Ser Ser Thr
100 105 110
Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Pro
115 120 125
Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Asp Ser Ser Thr Thr Ser
130 135 140
Ser Gly Ala Ser Thr Ala Thr Asn Ser Asp Ser Ser Thr Thr Ser Ser
145 150 155 160
Glu Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly
165 170 175
Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser Ser Arg Ala
180 185 190
Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Ser
195 200 205
Thr Ala Thr Asn Ser Glu Ser Arg Thr Thr Ser Asn Gly Ala Gly Thr
210 215 220
Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Ser Thr Ala
225 230 235 240
Thr Asn Ser Glu Ser Ser Thr Pro Ser Ser Gly Ala Gly Thr Ala Thr
245 250 255
Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala Gly Thr Ala Thr Asn
260 265 270
Ser Glu Ser Ser Thr Val Ser Ser Gly Ile Ser Thr Val Thr Asn Ser
275 280 285
Glu Ser Ser Thr Pro Ser Ser Gly Ala Asn Thr Ala Thr Asn Ser Glu
290 295 300
Ser Ser Thr Thr Ser Ser Gly Ala Asn Thr Ala Thr Asn Ser Asp Ser
305 310 315 320
Ser Thr Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser
325 330 335
Thr Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr
340 345 350
Thr Ser Ser Gly Ala Ser Thr Ala Thr Asn Ser Gly Ser Ser Thr Thr
355 360 365
Ser Ser Gly Thr Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser
370 375 380
Ser Gly Ala Ser Thr Ala Thr Thr Ser Glu Ser Ser Thr Thr Ser Ser
385 390 395 400
Gly Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Val Ser Ser Gly
405 410 415
Ala Ser Thr Ala Thr Asn Ser Glu Ser Ser Thr Thr Ser Ser Gly Ala
420 425 430
Asn Thr Ala Thr Asn Ser Gly Ser Ser Val Thr Ser Ala Gly Ser Gly
435 440 445
Thr Ala Ala Leu Thr Gly Met His Thr Thr Ser His Ser Ala Ser Thr
450 455 460
Ala Val Ser Glu Ala Lys Pro Gly Gly Ser Leu Val Pro Trp Glu Ile
465 470 475 480
Phe Leu Ile Thr Leu Val Ser Val Val Ala Ala Val Gly Leu Phe Ala
485 490 495
Gly Leu Phe Phe Cys Val Arg Asn Ser Leu Ser Leu Arg Asn Thr Phe
500 505 510
Asn Thr Ala Val Tyr His Pro His Gly Leu Asn His Gly Leu Gly Pro
515 520 525
Gly Pro Gly Gly Asn His Gly Ala Pro His Arg Pro Arg Trp Ser Pro
530 535 540
Asn Trp Phe Trp Arg Arg Pro Val Ser Ser Ile Ala Met Glu Met Ser
545 550 555 560
<210> 106
<211> 14507
<212> PRT
<213> 智人（Homo sapiens）
<400> 106
Met Leu Lys Pro Ser Gly Leu Pro Gly Ser Ser Ser Pro Thr Arg Ser
1 5 10 15
Leu Met Thr Gly Ser Arg Ser Thr Lys Ala Thr Pro Glu Met Asp Ser
20 25 30
Gly Leu Thr Gly Ala Thr Leu Ser Pro Lys Thr Ser Thr Gly Ala Ile
35 40 45
Val Val Thr Glu His Thr Leu Pro Phe Thr Ser Pro Asp Lys Thr Leu
50 55 60
Ala Ser Pro Thr Ser Ser Val Val Gly Arg Thr Thr Gln Ser Leu Gly
65 70 75 80
Val Met Ser Ser Ala Leu Pro Glu Ser Thr Ser Arg Gly Met Thr His
85 90 95
Ser Glu Gln Arg Thr Ser Pro Ser Leu Ser Pro Gln Val Asn Gly Thr
100 105 110
Pro Ser Arg Asn Tyr Pro Ala Thr Ser Met Val Ser Gly Leu Ser Ser
115 120 125
Pro Arg Thr Arg Thr Ser Ser Thr Glu Gly Asn Phe Thr Lys Glu Ala
130 135 140
Ser Thr Tyr Thr Leu Thr Val Glu Thr Thr Ser Gly Pro Val Thr Glu
145 150 155 160
Lys Tyr Thr Val Pro Thr Glu Thr Ser Thr Thr Glu Gly Asp Ser Thr
165 170 175
Glu Thr Pro Trp Asp Thr Arg Tyr Ile Pro Val Lys Ile Thr Ser Pro
180 185 190
Met Lys Thr Phe Ala Asp Ser Thr Ala Ser Lys Glu Asn Ala Pro Val
195 200 205
Ser Met Thr Pro Ala Glu Thr Thr Val Thr Asp Ser His Thr Pro Gly
210 215 220
Arg Thr Asn Pro Ser Phe Gly Thr Leu Tyr Ser Ser Phe Leu Asp Leu
225 230 235 240
Ser Pro Lys Gly Thr Pro Asn Ser Arg Gly Glu Thr Ser Leu Glu Leu
245 250 255
Ile Leu Ser Thr Thr Gly Tyr Pro Phe Ser Ser Pro Glu Pro Gly Ser
260 265 270
Ala Gly His Ser Arg Ile Ser Thr Ser Ala Pro Leu Ser Ser Ser Ala
275 280 285
Ser Val Leu Asp Asn Lys Ile Ser Glu Thr Ser Ile Phe Ser Gly Gln
290 295 300
Ser Leu Thr Ser Pro Leu Ser Pro Gly Val Pro Glu Ala Arg Ala Ser
305 310 315 320
Thr Met Pro Asn Ser Ala Ile Pro Phe Ser Met Thr Leu Ser Asn Ala
325 330 335
Glu Thr Ser Ala Glu Arg Val Arg Ser Thr Ile Ser Ser Leu Gly Thr
340 345 350
Pro Ser Ile Ser Thr Lys Gln Thr Ala Glu Thr Ile Leu Thr Phe His
355 360 365
Ala Phe Ala Glu Thr Met Asp Ile Pro Ser Thr His Ile Ala Lys Thr
370 375 380
Leu Ala Ser Glu Trp Leu Gly Ser Pro Gly Thr Leu Gly Gly Thr Ser
385 390 395 400
Thr Ser Ala Leu Thr Thr Thr Ser Pro Ser Thr Thr Leu Val Ser Glu
405 410 415
Glu Thr Asn Thr His His Ser Thr Ser Gly Lys Glu Thr Glu Gly Thr
420 425 430
Leu Asn Thr Ser Met Thr Pro Leu Glu Thr Ser Ala Pro Gly Glu Glu
435 440 445
Ser Glu Met Thr Ala Thr Leu Val Pro Thr Leu Gly Phe Thr Thr Leu
450 455 460
Asp Ser Lys Ile Arg Ser Pro Ser Gln Val Ser Ser Ser His Pro Thr
465 470 475 480
Arg Glu Leu Arg Thr Thr Gly Ser Thr Ser Gly Arg Gln Ser Ser Ser
485 490 495
Thr Ala Ala His Gly Ser Ser Asp Ile Leu Arg Ala Thr Thr Ser Ser
500 505 510
Thr Ser Lys Ala Ser Ser Trp Thr Ser Glu Ser Thr Ala Gln Gln Phe
515 520 525
Ser Glu Pro Gln His Thr Gln Trp Val Glu Thr Ser Pro Ser Met Lys
530 535 540
Thr Glu Arg Pro Pro Ala Ser Thr Ser Val Ala Ala Pro Ile Thr Thr
545 550 555 560
Ser Val Pro Ser Val Val Ser Gly Phe Thr Thr Leu Lys Thr Ser Ser
565 570 575
Thr Lys Gly Ile Trp Leu Glu Glu Thr Ser Ala Asp Thr Leu Ile Gly
580 585 590
Glu Ser Thr Ala Gly Pro Thr Thr His Gln Phe Ala Val Pro Thr Gly
595 600 605
Ile Ser Met Thr Gly Gly Ser Ser Thr Arg Gly Ser Gln Gly Thr Thr
610 615 620
His Leu Leu Thr Arg Ala Thr Ala Ser Ser Glu Thr Ser Ala Asp Leu
625 630 635 640
Thr Leu Ala Thr Asn Gly Val Pro Val Ser Val Ser Pro Ala Val Ser
645 650 655
Lys Thr Ala Ala Gly Ser Ser Pro Pro Gly Gly Thr Lys Pro Ser Tyr
660 665 670
Thr Met Val Ser Ser Val Ile Pro Glu Thr Ser Ser Leu Gln Ser Ser
675 680 685
Ala Phe Arg Glu Gly Thr Ser Leu Gly Leu Thr Pro Leu Asn Thr Arg
690 695 700
His Pro Phe Ser Ser Pro Glu Pro Asp Ser Ala Gly His Thr Lys Ile
705 710 715 720
Ser Thr Ser Ile Pro Leu Leu Ser Ser Ala Ser Val Leu Glu Asp Lys
725 730 735
Val Ser Ala Thr Ser Thr Phe Ser His His Lys Ala Thr Ser Ser Ile
740 745 750
Thr Thr Gly Thr Pro Glu Ile Ser Thr Lys Thr Lys Pro Ser Ser Ala
755 760 765
Val Leu Ser Ser Met Thr Leu Ser Asn Ala Ala Thr Ser Pro Glu Arg
770 775 780
Val Arg Asn Ala Thr Ser Pro Leu Thr His Pro Ser Pro Ser Gly Glu
785 790 795 800
Glu Thr Ala Gly Ser Val Leu Thr Leu Ser Thr Ser Ala Glu Thr Thr
805 810 815
Asp Ser Pro Asn Ile His Pro Thr Gly Thr Leu Thr Ser Glu Ser Ser
820 825 830
Glu Ser Pro Ser Thr Leu Ser Leu Pro Ser Val Ser Gly Val Lys Thr
835 840 845
Thr Phe Ser Ser Ser Thr Pro Ser Thr His Leu Phe Thr Ser Gly Glu
850 855 860
Glu Thr Glu Glu Thr Ser Asn Pro Ser Val Ser Gln Pro Glu Thr Ser
865 870 875 880
Val Ser Arg Val Arg Thr Thr Leu Ala Ser Thr Ser Val Pro Thr Pro
885 890 895
Val Phe Pro Thr Met Asp Thr Trp Pro Thr Arg Ser Ala Gln Phe Ser
900 905 910
Ser Ser His Leu Val Ser Glu Leu Arg Ala Thr Ser Ser Thr Ser Val
915 920 925
Thr Asn Ser Thr Gly Ser Ala Leu Pro Lys Ile Ser His Leu Thr Gly
930 935 940
Thr Ala Thr Met Ser Gln Thr Asn Arg Asp Thr Phe Asn Asp Ser Ala
945 950 955 960
Ala Pro Gln Ser Thr Thr Trp Pro Glu Thr Ser Pro Arg Phe Lys Thr
965 970 975
Gly Leu Pro Ser Ala Thr Thr Thr Val Ser Thr Ser Ala Thr Ser Leu
980 985 990
Ser Ala Thr Val Met Val Ser Lys Phe Thr Ser Pro Ala Thr Ser Ser
995 1000 1005
Met Glu Ala Thr Ser Ile Arg Glu Pro Ser Thr Thr Ile Leu Thr Thr
1010 1015 1020
Glu Thr Thr Asn Gly Pro Gly Ser Met Ala Val Ala Ser Thr Asn Ile
1025 1030 1035 1040
Pro Ile Gly Lys Gly Tyr Ile Thr Glu Gly Arg Leu Asp Thr Ser His
1045 1050 1055
Leu Pro Ile Gly Thr Thr Ala Ser Ser Glu Thr Ser Met Asp Phe Thr
1060 1065 1070
Met Ala Lys Glu Ser Val Ser Met Ser Val Ser Pro Ser Gln Ser Met
1075 1080 1085
Asp Ala Ala Gly Ser Ser Thr Pro Gly Arg Thr Ser Gln Phe Val Asp
1090 1095 1100
Thr Phe Ser Asp Asp Val Tyr His Leu Thr Ser Arg Glu Ile Thr Ile
1105 1110 1115 1120
Pro Arg Asp Gly Thr Ser Ser Ala Leu Thr Pro Gln Met Thr Ala Thr
1125 1130 1135
His Pro Pro Ser Pro Asp Pro Gly Ser Ala Arg Ser Thr Trp Leu Gly
1140 1145 1150
Ile Leu Ser Ser Ser Pro Ser Ser Pro Thr Pro Lys Val Thr Met Ser
1155 1160 1165
Ser Thr Phe Ser Thr Gln Arg Val Thr Thr Ser Met Ile Met Asp Thr
1170 1175 1180
Val Glu Thr Ser Arg Trp Asn Met Pro Asn Leu Pro Ser Thr Thr Ser
1185 1190 1195 1200
Leu Thr Pro Ser Asn Ile Pro Thr Ser Gly Ala Ile Gly Lys Ser Thr
1205 1210 1215
Leu Val Pro Leu Asp Thr Pro Ser Pro Ala Thr Ser Leu Glu Ala Ser
1220 1225 1230
Glu Gly Gly Leu Pro Thr Leu Ser Thr Tyr Pro Glu Ser Thr Asn Thr
1235 1240 1245
Pro Ser Ile His Leu Gly Ala His Ala Ser Ser Glu Ser Pro Ser Thr
1250 1255 1260
Ile Lys Leu Thr Met Ala Ser Val Val Lys Pro Gly Ser Tyr Thr Pro
1265 1270 1275 1280
Leu Thr Phe Pro Ser Ile Glu Thr His Ile His Val Ser Thr Ala Arg
1285 1290 1295
Met Ala Tyr Ser Ser Gly Ser Ser Pro Glu Met Thr Ala Pro Gly Glu
1300 1305 1310
Thr Asn Thr Gly Ser Thr Trp Asp Pro Thr Thr Tyr Ile Thr Thr Thr
1315 1320 1325
Asp Pro Lys Asp Thr Ser Ser Ala Gln Val Ser Thr Pro His Ser Val
1330 1335 1340
Arg Thr Leu Arg Thr Thr Glu Asn His Pro Lys Thr Glu Ser Ala Thr
1345 1350 1355 1360
Pro Ala Ala Tyr Ser Gly Ser Pro Lys Ile Ser Ser Ser Pro Asn Leu
1365 1370 1375
Thr Ser Pro Ala Thr Lys Ala Trp Thr Ile Thr Asp Thr Thr Glu His
1380 1385 1390
Ser Thr Gln Leu His Tyr Thr Lys Leu Ala Glu Lys Ser Ser Gly Phe
1395 1400 1405
Glu Thr Gln Ser Ala Pro Gly Pro Val Ser Val Val Ile Pro Thr Ser
1410 1415 1420
Pro Thr Ile Gly Ser Ser Thr Leu Glu Leu Thr Ser Asp Val Pro Gly
1425 1430 1435 1440
Glu Pro Leu Val Leu Ala Pro Ser Glu Gln Thr Thr Ile Thr Leu Pro
1445 1450 1455
Met Ala Thr Trp Leu Ser Thr Ser Leu Thr Glu Glu Met Ala Ser Thr
1460 1465 1470
Asp Leu Asp Ile Ser Ser Pro Ser Ser Pro Met Ser Thr Phe Ala Ile
1475 1480 1485
Phe Pro Pro Met Ser Thr Pro Ser His Glu Leu Ser Lys Ser Glu Ala
1490 1495 1500
Asp Thr Ser Ala Ile Arg Asn Thr Asp Ser Thr Thr Leu Asp Gln His
1505 1510 1515 1520
Leu Gly Ile Arg Ser Leu Gly Arg Thr Gly Asp Leu Thr Thr Val Pro
1525 1530 1535
Ile Thr Pro Leu Thr Thr Thr Trp Thr Ser Val Ile Glu His Ser Thr
1540 1545 1550
Gln Ala Gln Asp Thr Leu Ser Ala Thr Met Ser Pro Thr His Val Thr
1555 1560 1565
Gln Ser Leu Lys Asp Gln Thr Ser Ile Pro Ala Ser Ala Ser Pro Ser
1570 1575 1580
His Leu Thr Glu Val Tyr Pro Glu Leu Gly Thr Gln Gly Arg Ser Ser
1585 1590 1595 1600
Ser Glu Ala Thr Thr Phe Trp Lys Pro Ser Thr Asp Thr Leu Ser Arg
1605 1610 1615
Glu Ile Glu Thr Gly Pro Thr Asn Ile Gln Ser Thr Pro Pro Met Asp
1620 1625 1630
Asn Thr Thr Thr Gly Ser Ser Ser Ser Gly Val Thr Leu Gly Ile Ala
1635 1640 1645
His Leu Pro Ile Gly Thr Ser Ser Pro Ala Glu Thr Ser Thr Asn Met
1650 1655 1660
Ala Leu Glu Arg Arg Ser Ser Thr Ala Thr Val Ser Met Ala Gly Thr
1665 1670 1675 1680
Met Gly Leu Leu Val Thr Ser Ala Pro Gly Arg Ser Ile Ser Gln Ser
1685 1690 1695
Leu Gly Arg Val Ser Ser Val Leu Ser Glu Ser Thr Thr Glu Gly Val
1700 1705 1710
Thr Asp Ser Ser Lys Gly Ser Ser Pro Arg Leu Asn Thr Gln Gly Asn
1715 1720 1725
Thr Ala Leu Ser Ser Ser Leu Glu Pro Ser Tyr Ala Glu Gly Ser Gln
1730 1735 1740
Met Ser Thr Ser Ile Pro Leu Thr Ser Ser Pro Thr Thr Pro Asp Val
1745 1750 1755 1760
Glu Phe Ile Gly Gly Ser Thr Phe Trp Thr Lys Glu Val Thr Thr Val
1765 1770 1775
Met Thr Ser Asp Ile Ser Lys Ser Ser Ala Arg Thr Glu Ser Ser Ser
1780 1785 1790
Ala Thr Leu Met Ser Thr Ala Leu Gly Ser Thr Glu Asn Thr Gly Lys
1795 1800 1805
Glu Lys Leu Arg Thr Ala Ser Met Asp Leu Pro Ser Pro Thr Pro Ser
1810 1815 1820
Met Glu Val Thr Pro Trp Ile Ser Leu Thr Leu Ser Asn Ala Pro Asn
1825 1830 1835 1840
Thr Thr Asp Ser Leu Asp Leu Ser His Gly Val His Thr Ser Ser Ala
1845 1850 1855
Gly Thr Leu Ala Thr Asp Arg Ser Leu Asn Thr Gly Val Thr Arg Ala
1860 1865 1870
Ser Arg Leu Glu Asn Gly Ser Asp Thr Ser Ser Lys Ser Leu Ser Met
1875 1880 1885
Gly Asn Ser Thr His Thr Ser Met Thr Tyr Thr Glu Lys Ser Glu Val
1890 1895 1900
Ser Ser Ser Ile His Pro Arg Pro Glu Thr Ser Ala Pro Gly Ala Glu
1905 1910 1915 1920
Thr Thr Leu Thr Ser Thr Pro Gly Asn Arg Ala Ile Ser Leu Thr Leu
1925 1930 1935
Pro Phe Ser Ser Ile Pro Val Glu Glu Val Ile Ser Thr Gly Ile Thr
1940 1945 1950
Ser Gly Pro Asp Ile Asn Ser Ala Pro Met Thr His Ser Pro Ile Thr
1955 1960 1965
Pro Pro Thr Ile Val Trp Thr Ser Thr Gly Thr Ile Glu Gln Ser Thr
1970 1975 1980
Gln Pro Leu His Ala Val Ser Ser Glu Lys Val Ser Val Gln Thr Gln
1985 1990 1995 2000
Ser Thr Pro Tyr Val Asn Ser Val Ala Val Ser Ala Ser Pro Thr His
2005 2010 2015
Glu Asn Ser Val Ser Ser Gly Ser Ser Thr Ser Ser Pro Tyr Ser Ser
2020 2025 2030
Ala Ser Leu Glu Ser Leu Asp Ser Thr Ile Ser Arg Arg Asn Ala Ile
2035 2040 2045
Thr Ser Trp Leu Trp Asp Leu Thr Thr Ser Leu Pro Thr Thr Thr Trp
2050 2055 2060
Pro Ser Thr Ser Leu Ser Glu Ala Leu Ser Ser Gly His Ser Gly Val
2065 2070 2075 2080
Ser Asn Pro Ser Ser Thr Thr Thr Glu Phe Pro Leu Phe Ser Ala Ala
2085 2090 2095
Ser Thr Ser Ala Ala Lys Gln Arg Asn Pro Glu Thr Glu Thr His Gly
2100 2105 2110
Pro Gln Asn Thr Ala Ala Ser Thr Leu Asn Thr Asp Ala Ser Ser Val
2115 2120 2125
Thr Gly Leu Ser Glu Thr Pro Val Gly Ala Ser Ile Ser Ser Glu Val
2130 2135 2140
Pro Leu Pro Met Ala Ile Thr Ser Arg Ser Asp Val Ser Gly Leu Thr
2145 2150 2155 2160
Ser Glu Ser Thr Ala Asn Pro Ser Leu Gly Thr Ala Ser Ser Ala Gly
2165 2170 2175
Thr Lys Leu Thr Arg Thr Ile Ser Leu Pro Thr Ser Glu Ser Leu Val
2180 2185 2190
Ser Phe Arg Met Asn Lys Asp Pro Trp Thr Val Ser Ile Pro Leu Gly
2195 2200 2205
Ser His Pro Thr Thr Asn Thr Glu Thr Ser Ile Pro Val Asn Ser Ala
2210 2215 2220
Gly Pro Pro Gly Leu Ser Thr Val Ala Ser Asp Val Ile Asp Thr Pro
2225 2230 2235 2240
Ser Asp Gly Ala Glu Ser Ile Pro Thr Val Ser Phe Ser Pro Ser Pro
2245 2250 2255
Asp Thr Glu Val Thr Thr Ile Ser His Phe Pro Glu Lys Thr Thr His
2260 2265 2270
Ser Phe Arg Thr Ile Ser Ser Leu Thr His Glu Leu Thr Ser Arg Val
2275 2280 2285
Thr Pro Ile Pro Gly Asp Trp Met Ser Ser Ala Met Ser Thr Lys Pro
2290 2295 2300
Thr Gly Ala Ser Pro Ser Ile Thr Leu Gly Glu Arg Arg Thr Ile Thr
2305 2310 2315 2320
Ser Ala Ala Pro Thr Thr Ser Pro Ile Val Leu Thr Ala Ser Phe Thr
2325 2330 2335
Glu Thr Ser Thr Val Ser Leu Asp Asn Glu Thr Thr Val Lys Thr Ser
2340 2345 2350
Asp Ile Leu Asp Ala Arg Lys Thr Asn Glu Leu Pro Ser Asp Ser Ser
2355 2360 2365
Ser Ser Ser Asp Leu Ile Asn Thr Ser Ile Ala Ser Ser Thr Met Asp
2370 2375 2380
Val Thr Lys Thr Ala Ser Ile Ser Pro Thr Ser Ile Ser Gly Met Thr
2385 2390 2395 2400
Ala Ser Ser Ser Pro Ser Leu Phe Ser Ser Asp Arg Pro Gln Val Pro
2405 2410 2415
Thr Ser Thr Thr Glu Thr Asn Thr Ala Thr Ser Pro Ser Val Ser Ser
2420 2425 2430
Asn Thr Tyr Ser Leu Asp Gly Gly Ser Asn Val Gly Gly Thr Pro Ser
2435 2440 2445
Thr Leu Pro Pro Phe Thr Ile Thr His Pro Val Glu Thr Ser Ser Ala
2450 2455 2460
Leu Leu Ala Trp Ser Arg Pro Val Arg Thr Phe Ser Thr Met Val Ser
2465 2470 2475 2480
Thr Asp Thr Ala Ser Gly Glu Asn Pro Thr Ser Ser Asn Ser Val Val
2485 2490 2495
Thr Ser Val Pro Ala Pro Gly Thr Trp Thr Ser Val Gly Ser Thr Thr
2500 2505 2510
Asp Leu Pro Ala Met Gly Phe Leu Lys Thr Ser Pro Ala Gly Glu Ala
2515 2520 2525
His Ser Leu Leu Ala Ser Thr Ile Glu Pro Ala Thr Ala Phe Thr Pro
2530 2535 2540
His Leu Ser Ala Ala Val Val Thr Gly Ser Ser Ala Thr Ser Glu Ala
2545 2550 2555 2560
Ser Leu Leu Thr Thr Ser Glu Ser Lys Ala Ile His Ser Ser Pro Gln
2565 2570 2575
Thr Pro Thr Thr Pro Thr Ser Gly Ala Asn Trp Glu Thr Ser Ala Thr
2580 2585 2590
Pro Glu Ser Leu Leu Val Val Thr Glu Thr Ser Asp Thr Thr Leu Thr
2595 2600 2605
Ser Lys Ile Leu Val Thr Asp Thr Ile Leu Phe Ser Thr Val Ser Thr
2610 2615 2620
Pro Pro Ser Lys Phe Pro Ser Thr Gly Thr Leu Ser Gly Ala Ser Phe
2625 2630 2635 2640
Pro Thr Leu Leu Pro Asp Thr Pro Ala Ile Pro Leu Thr Ala Thr Glu
2645 2650 2655
Pro Thr Ser Ser Leu Ala Thr Ser Phe Asp Ser Thr Pro Leu Val Thr
2660 2665 2670
Ile Ala Ser Asp Ser Leu Gly Thr Val Pro Glu Thr Thr Leu Thr Met
2675 2680 2685
Ser Glu Thr Ser Asn Gly Asp Ala Leu Val Leu Lys Thr Val Ser Asn
2690 2695 2700
Pro Asp Arg Ser Ile Pro Gly Ile Thr Ile Gln Gly Val Thr Glu Ser
2705 2710 2715 2720
Pro Leu His Pro Ser Ser Thr Ser Pro Ser Lys Ile Val Ala Pro Arg
2725 2730 2735
Asn Thr Thr Tyr Glu Gly Ser Ile Thr Val Ala Leu Ser Thr Leu Pro
2740 2745 2750
Ala Gly Thr Thr Gly Ser Leu Val Phe Ser Gln Ser Ser Glu Asn Ser
2755 2760 2765
Glu Thr Thr Ala Leu Val Asp Ser Ser Ala Gly Leu Glu Arg Ala Ser
2770 2775 2780
Val Met Pro Leu Thr Thr Gly Ser Gln Gly Met Ala Ser Ser Gly Gly
2785 2790 2795 2800
Ile Arg Ser Gly Ser Thr His Ser Thr Gly Thr Lys Thr Phe Ser Ser
2805 2810 2815
Leu Pro Leu Thr Met Asn Pro Gly Glu Val Thr Ala Met Ser Glu Ile
2820 2825 2830
Thr Thr Asn Arg Leu Thr Ala Thr Gln Ser Thr Ala Pro Lys Gly Ile
2835 2840 2845
Pro Val Lys Pro Thr Ser Ala Glu Ser Gly Leu Leu Thr Pro Val Ser
2850 2855 2860
Ala Ser Ser Ser Pro Ser Lys Ala Phe Ala Ser Leu Thr Thr Ala Pro
2865 2870 2875 2880
Pro Thr Trp Gly Ile Pro Gln Ser Thr Leu Thr Phe Glu Phe Ser Glu
2885 2890 2895
Val Pro Ser Leu Asp Thr Lys Ser Ala Ser Leu Pro Thr Pro Gly Gln
2900 2905 2910
Ser Leu Asn Thr Ile Pro Asp Ser Asp Ala Ser Thr Ala Ser Ser Ser
2915 2920 2925
Leu Ser Lys Ser Pro Glu Lys Asn Pro Arg Ala Arg Met Met Thr Ser
2930 2935 2940
Thr Lys Ala Ile Ser Ala Ser Ser Phe Gln Ser Thr Gly Phe Thr Glu
2945 2950 2955 2960
Thr Pro Glu Gly Ser Ala Ser Pro Ser Met Ala Gly His Glu Pro Arg
2965 2970 2975
Val Pro Thr Ser Gly Thr Gly Asp Pro Arg Tyr Ala Ser Glu Ser Met
2980 2985 2990
Ser Tyr Pro Asp Pro Ser Lys Ala Ser Ser Ala Met Thr Ser Thr Ser
2995 3000 3005
Leu Ala Ser Lys Leu Thr Thr Leu Phe Ser Thr Gly Gln Ala Ala Arg
3010 3015 3020
Ser Gly Ser Ser Ser Ser Pro Ile Ser Leu Ser Thr Glu Lys Glu Thr
3025 3030 3035 3040
Ser Phe Leu Ser Pro Thr Ala Ser Thr Ser Arg Lys Thr Ser Leu Phe
3045 3050 3055
Leu Gly Pro Ser Met Ala Arg Gln Pro Asn Ile Leu Val His Leu Gln
3060 3065 3070
Thr Ser Ala Leu Thr Leu Ser Pro Thr Ser Thr Leu Asn Met Ser Gln
3075 3080 3085
Glu Glu Pro Pro Glu Leu Thr Ser Ser Gln Thr Ile Ala Glu Glu Glu
3090 3095 3100
Gly Thr Thr Ala Glu Thr Gln Thr Leu Thr Phe Thr Pro Ser Glu Thr
3105 3110 3115 3120
Pro Thr Ser Leu Leu Pro Val Ser Ser Pro Thr Glu Pro Thr Ala Arg
3125 3130 3135
Arg Lys Ser Ser Pro Glu Thr Trp Ala Ser Ser Ile Ser Val Pro Ala
3140 3145 3150
Lys Thr Ser Leu Val Glu Thr Thr Asp Gly Thr Leu Val Thr Thr Ile
3155 3160 3165
Lys Met Ser Ser Gln Ala Ala Gln Gly Asn Ser Thr Trp Pro Ala Pro
3170 3175 3180
Ala Glu Glu Thr Gly Ser Ser Pro Ala Gly Thr Ser Pro Gly Ser Pro
3185 3190 3195 3200
Glu Met Ser Thr Thr Leu Lys Ile Met Ser Ser Lys Glu Pro Ser Ile
3205 3210 3215
Ser Pro Glu Ile Arg Ser Thr Val Arg Asn Ser Pro Trp Lys Thr Pro
3220 3225 3230
Glu Thr Thr Val Pro Met Glu Thr Thr Val Glu Pro Val Thr Leu Gln
3235 3240 3245
Ser Thr Ala Leu Gly Ser Gly Ser Thr Ser Ile Ser His Leu Pro Thr
3250 3255 3260
Gly Thr Thr Ser Pro Thr Lys Ser Pro Thr Glu Asn Met Leu Ala Thr
3265 3270 3275 3280
Glu Arg Val Ser Leu Ser Pro Ser Pro Pro Glu Ala Trp Thr Asn Leu
3285 3290 3295
Tyr Ser Gly Thr Pro Gly Gly Thr Arg Gln Ser Leu Ala Thr Met Ser
3300 3305 3310
Ser Val Ser Leu Glu Ser Pro Thr Ala Arg Ser Ile Thr Gly Thr Gly
3315 3320 3325
Gln Gln Ser Ser Pro Glu Leu Val Ser Lys Thr Thr Gly Met Glu Phe
3330 3335 3340
Ser Met Trp His Gly Ser Thr Gly Gly Thr Thr Gly Asp Thr His Val
3345 3350 3355 3360
Ser Leu Ser Thr Ser Ser Asn Ile Leu Glu Asp Pro Val Thr Ser Pro
3365 3370 3375
Asn Ser Val Ser Ser Leu Thr Asp Lys Ser Lys His Lys Thr Glu Thr
3380 3385 3390
Trp Val Ser Thr Thr Ala Ile Pro Ser Thr Val Leu Asn Asn Lys Ile
3395 3400 3405
Met Ala Ala Glu Gln Gln Thr Ser Arg Ser Val Asp Glu Ala Tyr Ser
3410 3415 3420
Ser Thr Ser Ser Trp Ser Asp Gln Thr Ser Gly Ser Asp Ile Thr Leu
3425 3430 3435 3440
Gly Ala Ser Pro Asp Val Thr Asn Thr Leu Tyr Ile Thr Ser Thr Ala
3445 3450 3455
Gln Thr Thr Ser Leu Val Ser Leu Pro Ser Gly Asp Gln Gly Ile Thr
3460 3465 3470
Ser Leu Thr Asn Pro Ser Gly Gly Lys Thr Ser Ser Ala Ser Ser Val
3475 3480 3485
Thr Ser Pro Ser Ile Gly Leu Glu Thr Leu Arg Ala Asn Val Ser Ala
3490 3495 3500
Val Lys Ser Asp Ile Ala Pro Thr Ala Gly His Leu Ser Gln Thr Ser
3505 3510 3515 3520
Ser Pro Ala Glu Val Ser Ile Leu Asp Val Thr Thr Ala Pro Thr Pro
3525 3530 3535
Gly Ile Ser Thr Thr Ile Thr Thr Met Gly Thr Asn Ser Ile Ser Thr
3540 3545 3550
Thr Thr Pro Asn Pro Glu Val Gly Met Ser Thr Met Asp Ser Thr Pro
3555 3560 3565
Ala Thr Glu Arg Arg Thr Thr Ser Thr Glu His Pro Ser Thr Trp Ser
3570 3575 3580
Ser Thr Ala Ala Ser Asp Ser Trp Thr Val Thr Asp Met Thr Ser Asn
3585 3590 3595 3600
Leu Lys Val Ala Arg Ser Pro Gly Thr Ile Ser Thr Met His Thr Thr
3605 3610 3615
Ser Phe Leu Ala Ser Ser Thr Glu Leu Asp Ser Met Ser Thr Pro His
3620 3625 3630
Gly Arg Ile Thr Val Ile Gly Thr Ser Leu Val Thr Pro Ser Ser Asp
3635 3640 3645
Ala Ser Ala Val Lys Thr Glu Thr Ser Thr Ser Glu Arg Thr Leu Ser
3650 3655 3660
Pro Ser Asp Thr Thr Ala Ser Thr Pro Ile Ser Thr Phe Ser Arg Val
3665 3670 3675 3680
Gln Arg Met Ser Ile Ser Val Pro Asp Ile Leu Ser Thr Ser Trp Thr
3685 3690 3695
Pro Ser Ser Thr Glu Ala Glu Asp Val Pro Val Ser Met Val Ser Thr
3700 3705 3710
Asp His Ala Ser Thr Lys Thr Asp Pro Asn Thr Pro Leu Ser Thr Phe
3715 3720 3725
Leu Phe Asp Ser Leu Ser Thr Leu Asp Trp Asp Thr Gly Arg Ser Leu
3730 3735 3740
Ser Ser Ala Thr Ala Thr Thr Ser Ala Pro Gln Gly Ala Thr Thr Pro
3745 3750 3755 3760
Gln Glu Leu Thr Leu Glu Thr Met Ile Ser Pro Ala Thr Ser Gln Leu
3765 3770 3775
Pro Phe Ser Ile Gly His Ile Thr Ser Ala Val Thr Pro Ala Ala Met
3780 3785 3790
Ala Arg Ser Ser Gly Val Thr Phe Ser Arg Pro Asp Pro Thr Ser Lys
3795 3800 3805
Lys Ala Glu Gln Thr Ser Thr Gln Leu Pro Thr Thr Thr Ser Ala His
3810 3815 3820
Pro Gly Gln Val Pro Arg Ser Ala Ala Thr Thr Leu Asp Val Ile Pro
3825 3830 3835 3840
His Thr Ala Lys Thr Pro Asp Ala Thr Phe Gln Arg Gln Gly Gln Thr
3845 3850 3855
Ala Leu Thr Thr Glu Ala Arg Ala Thr Ser Asp Ser Trp Asn Glu Lys
3860 3865 3870
Glu Lys Ser Thr Pro Ser Ala Pro Trp Ile Thr Glu Met Met Asn Ser
3875 3880 3885
Val Ser Glu Asp Thr Ile Lys Glu Val Thr Ser Ser Ser Ser Val Leu
3890 3895 3900
Arg Thr Leu Asn Thr Leu Asp Ile Asn Leu Glu Ser Gly Thr Thr Ser
3905 3910 3915 3920
Ser Pro Ser Trp Lys Ser Ser Pro Tyr Glu Arg Ile Ala Pro Ser Glu
3925 3930 3935
Ser Thr Thr Asp Lys Glu Ala Ile His Pro Ser Thr Asn Thr Val Glu
3940 3945 3950
Thr Thr Gly Trp Val Thr Ser Ser Glu His Ala Ser His Ser Thr Ile
3955 3960 3965
Pro Ala His Ser Ala Ser Ser Lys Leu Thr Ser Pro Val Val Thr Thr
3970 3975 3980
Ser Thr Arg Glu Gln Ala Ile Val Ser Met Ser Thr Thr Thr Trp Pro
3985 3990 3995 4000
Glu Ser Thr Arg Ala Arg Thr Glu Pro Asn Ser Phe Leu Thr Ile Glu
4005 4010 4015
Leu Arg Asp Val Ser Pro Tyr Met Asp Thr Ser Ser Thr Thr Gln Thr
4020 4025 4030
Ser Ile Ile Ser Ser Pro Gly Ser Thr Ala Ile Thr Lys Gly Pro Arg
4035 4040 4045
Thr Glu Ile Thr Ser Ser Lys Arg Ile Ser Ser Ser Phe Leu Ala Gln
4050 4055 4060
Ser Met Arg Ser Ser Asp Ser Pro Ser Glu Ala Ile Thr Arg Leu Ser
4065 4070 4075 4080
Asn Phe Pro Ala Met Thr Glu Ser Gly Gly Met Ile Leu Ala Met Gln
4085 4090 4095
Thr Ser Pro Pro Gly Ala Thr Ser Leu Ser Ala Pro Thr Leu Asp Thr
4100 4105 4110
Ser Ala Thr Ala Ser Trp Thr Gly Thr Pro Leu Ala Thr Thr Gln Arg
4115 4120 4125
Phe Thr Tyr Ser Glu Lys Thr Thr Leu Phe Ser Lys Gly Pro Glu Asp
4130 4135 4140
Thr Ser Gln Pro Ser Pro Pro Ser Val Glu Glu Thr Ser Ser Ser Ser
4145 4150 4155 4160
Ser Leu Val Pro Ile His Ala Thr Thr Ser Pro Ser Asn Ile Leu Leu
4165 4170 4175
Thr Ser Gln Gly His Ser Pro Ser Ser Thr Pro Pro Val Thr Ser Val
4180 4185 4190
Phe Leu Ser Glu Thr Ser Gly Leu Gly Lys Thr Thr Asp Met Ser Arg
4195 4200 4205
Ile Ser Leu Glu Pro Gly Thr Ser Leu Pro Pro Asn Leu Ser Ser Thr
4210 4215 4220
Ala Gly Glu Ala Leu Ser Thr Tyr Glu Ala Ser Arg Asp Thr Lys Ala
4225 4230 4235 4240
Ile His His Ser Ala Asp Thr Ala Val Thr Asn Met Glu Ala Thr Ser
4245 4250 4255
Ser Glu Tyr Ser Pro Ile Pro Gly His Thr Lys Pro Ser Lys Ala Thr
4260 4265 4270
Ser Pro Leu Val Thr Ser His Ile Met Gly Asp Ile Thr Ser Ser Thr
4275 4280 4285
Ser Val Phe Gly Ser Ser Glu Thr Thr Glu Ile Glu Thr Val Ser Ser
4290 4295 4300
Val Asn Gln Gly Leu Gln Glu Arg Ser Thr Ser Gln Val Ala Ser Ser
4305 4310 4315 4320
Ala Thr Glu Thr Ser Thr Val Ile Thr His Val Ser Ser Gly Asp Ala
4325 4330 4335
Thr Thr His Val Thr Lys Thr Gln Ala Thr Phe Ser Ser Gly Thr Ser
4340 4345 4350
Ile Ser Ser Pro His Gln Phe Ile Thr Ser Thr Asn Thr Phe Thr Asp
4355 4360 4365
Val Ser Thr Asn Pro Ser Thr Ser Leu Ile Met Thr Glu Ser Ser Gly
4370 4375 4380
Val Thr Ile Thr Thr Gln Thr Gly Pro Thr Gly Ala Ala Thr Gln Gly
4385 4390 4395 4400
Pro Tyr Leu Leu Asp Thr Ser Thr Met Pro Tyr Leu Thr Glu Thr Pro
4405 4410 4415
Leu Ala Val Thr Pro Asp Phe Met Gln Ser Glu Lys Thr Thr Leu Ile
4420 4425 4430
Ser Lys Gly Pro Lys Asp Val Ser Trp Thr Ser Pro Pro Ser Val Ala
4435 4440 4445
Glu Thr Ser Tyr Pro Ser Ser Leu Thr Pro Phe Leu Val Thr Thr Ile
4450 4455 4460
Pro Pro Ala Thr Ser Thr Leu Gln Gly Gln His Thr Ser Ser Pro Val
4465 4470 4475 4480
Ser Ala Thr Ser Val Leu Thr Ser Gly Leu Val Lys Thr Thr Asp Met
4485 4490 4495
Leu Asn Thr Ser Met Glu Pro Val Thr Asn Ser Pro Gln Asn Leu Asn
4500 4505 4510
Asn Pro Ser Asn Glu Ile Leu Ala Thr Leu Ala Ala Thr Thr Asp Ile
4515 4520 4525
Glu Thr Ile His Pro Ser Ile Asn Lys Ala Val Thr Asn Met Gly Thr
4530 4535 4540
Ala Ser Ser Ala His Val Leu His Ser Thr Leu Pro Val Ser Ser Glu
4545 4550 4555 4560
Pro Ser Thr Ala Thr Ser Pro Met Val Pro Ala Ser Ser Met Gly Asp
4565 4570 4575
Ala Leu Ala Ser Ile Ser Ile Pro Gly Ser Glu Thr Thr Asp Ile Glu
4580 4585 4590
Gly Glu Pro Thr Ser Ser Leu Thr Ala Gly Arg Lys Glu Asn Ser Thr
4595 4600 4605
Leu Gln Glu Met Asn Ser Thr Thr Glu Ser Asn Ile Ile Leu Ser Asn
4610 4615 4620
Val Ser Val Gly Ala Ile Thr Glu Ala Thr Lys Met Glu Val Pro Ser
4625 4630 4635 4640
Phe Asp Ala Thr Phe Ile Pro Thr Pro Ala Gln Ser Thr Lys Phe Pro
4645 4650 4655
Asp Ile Phe Ser Val Ala Ser Ser Arg Leu Ser Asn Ser Pro Pro Met
4660 4665 4670
Thr Ile Ser Thr His Met Thr Thr Thr Gln Thr Gly Ser Ser Gly Ala
4675 4680 4685
Thr Ser Lys Ile Pro Leu Ala Leu Asp Thr Ser Thr Leu Glu Thr Ser
4690 4695 4700
Ala Gly Thr Pro Ser Val Val Thr Glu Gly Phe Ala His Ser Lys Ile
4705 4710 4715 4720
Thr Thr Ala Met Asn Asn Asp Val Lys Asp Val Ser Gln Thr Asn Pro
4725 4730 4735
Pro Phe Gln Asp Glu Ala Ser Ser Pro Ser Ser Gln Ala Pro Val Leu
4740 4745 4750
Val Thr Thr Leu Pro Ser Ser Val Ala Phe Thr Pro Gln Trp His Ser
4755 4760 4765
Thr Ser Ser Pro Val Ser Met Ser Ser Val Leu Thr Ser Ser Leu Val
4770 4775 4780
Lys Thr Ala Gly Lys Val Asp Thr Ser Leu Glu Thr Val Thr Ser Ser
4785 4790 4795 4800
Pro Gln Ser Met Ser Asn Thr Leu Asp Asp Ile Ser Val Thr Ser Ala
4805 4810 4815
Ala Thr Thr Asp Ile Glu Thr Thr His Pro Ser Ile Asn Thr Val Val
4820 4825 4830
Thr Asn Val Gly Thr Thr Gly Ser Ala Phe Glu Ser His Ser Thr Val
4835 4840 4845
Ser Ala Tyr Pro Glu Pro Ser Lys Val Thr Ser Pro Asn Val Thr Thr
4850 4855 4860
Ser Thr Met Glu Asp Thr Thr Ile Ser Arg Ser Ile Pro Lys Ser Ser
4865 4870 4875 4880
Lys Thr Thr Arg Thr Glu Thr Glu Thr Thr Ser Ser Leu Thr Pro Lys
4885 4890 4895
Leu Arg Glu Thr Ser Ile Ser Gln Glu Ile Thr Ser Ser Thr Glu Thr
4900 4905 4910
Ser Thr Val Pro Tyr Lys Glu Leu Thr Gly Ala Thr Thr Glu Val Ser
4915 4920 4925
Arg Thr Asp Val Thr Ser Ser Ser Ser Thr Ser Phe Pro Gly Pro Asp
4930 4935 4940
Gln Ser Thr Val Ser Leu Asp Ile Ser Thr Glu Thr Asn Thr Arg Leu
4945 4950 4955 4960
Ser Thr Ser Pro Ile Met Thr Glu Ser Ala Glu Ile Thr Ile Thr Thr
4965 4970 4975
Gln Thr Gly Pro His Gly Ala Thr Ser Gln Asp Thr Phe Thr Met Asp
4980 4985 4990
Pro Ser Asn Thr Thr Pro Gln Ala Gly Ile His Ser Ala Met Thr His
4995 5000 5005
Gly Phe Ser Gln Leu Asp Val Thr Thr Leu Met Ser Arg Ile Pro Gln
5010 5015 5020
Asp Val Ser Trp Thr Ser Pro Pro Ser Val Asp Lys Thr Ser Ser Pro
5025 5030 5035 5040
Ser Ser Phe Leu Ser Ser Pro Ala Met Thr Thr Pro Ser Leu Ile Ser
5045 5050 5055
Ser Thr Leu Pro Glu Asp Lys Leu Ser Ser Pro Met Thr Ser Leu Leu
5060 5065 5070
Thr Ser Gly Leu Val Lys Ile Thr Asp Ile Leu Arg Thr Arg Leu Glu
5075 5080 5085
Pro Val Thr Ser Ser Leu Pro Asn Phe Ser Ser Thr Ser Asp Lys Ile
5090 5095 5100
Leu Ala Thr Ser Lys Asp Ser Lys Asp Thr Lys Glu Ile Phe Pro Ser
5105 5110 5115 5120
Ile Asn Thr Glu Glu Thr Asn Val Lys Ala Asn Asn Ser Gly His Glu
5125 5130 5135
Ser His Ser Pro Ala Leu Ala Asp Ser Glu Thr Pro Lys Ala Thr Thr
5140 5145 5150
Gln Met Val Ile Thr Thr Thr Val Gly Asp Pro Ala Pro Ser Thr Ser
5155 5160 5165
Met Pro Val His Gly Ser Ser Glu Thr Thr Asn Ile Lys Arg Glu Pro
5170 5175 5180
Thr Tyr Phe Leu Thr Pro Arg Leu Arg Glu Thr Ser Thr Ser Gln Glu
5185 5190 5195 5200
Ser Ser Phe Pro Thr Asp Thr Ser Phe Leu Leu Ser Lys Val Pro Thr
5205 5210 5215
Gly Thr Ile Thr Glu Val Ser Ser Thr Gly Val Asn Ser Ser Ser Lys
5220 5225 5230
Ile Ser Thr Pro Asp His Asp Lys Ser Thr Val Pro Pro Asp Thr Phe
5235 5240 5245
Thr Gly Glu Ile Pro Arg Val Phe Thr Ser Ser Ile Lys Thr Lys Ser
5250 5255 5260
Ala Glu Met Thr Ile Thr Thr Gln Ala Ser Pro Pro Glu Ser Ala Ser
5265 5270 5275 5280
His Ser Thr Leu Pro Leu Asp Thr Ser Thr Thr Leu Ser Gln Gly Gly
5285 5290 5295
Thr His Ser Thr Val Thr Gln Gly Phe Pro Tyr Ser Glu Val Thr Thr
5300 5305 5310
Leu Met Gly Met Gly Pro Gly Asn Val Ser Trp Met Thr Thr Pro Pro
5315 5320 5325
Val Glu Glu Thr Ser Ser Val Ser Ser Leu Met Ser Ser Pro Ala Met
5330 5335 5340
Thr Ser Pro Ser Pro Val Ser Ser Thr Ser Pro Gln Ser Ile Pro Ser
5345 5350 5355 5360
Ser Pro Leu Pro Val Thr Ala Leu Pro Thr Ser Val Leu Val Thr Thr
5365 5370 5375
Thr Asp Val Leu Gly Thr Thr Ser Pro Glu Ser Val Thr Ser Ser Pro
5380 5385 5390
Pro Asn Leu Ser Ser Ile Thr His Glu Arg Pro Ala Thr Tyr Lys Asp
5395 5400 5405
Thr Ala His Thr Glu Ala Ala Met His His Ser Thr Asn Thr Ala Val
5410 5415 5420
Thr Asn Val Gly Thr Ser Gly Ser Gly His Lys Ser Gln Ser Ser Val
5425 5430 5435 5440
Leu Ala Asp Ser Glu Thr Ser Lys Ala Thr Pro Leu Met Ser Thr Thr
5445 5450 5455
Ser Thr Leu Gly Asp Thr Ser Val Ser Thr Ser Thr Pro Asn Ile Ser
5460 5465 5470
Gln Thr Asn Gln Ile Gln Thr Glu Pro Thr Ala Ser Leu Ser Pro Arg
5475 5480 5485
Leu Arg Glu Ser Ser Thr Ser Glu Lys Thr Ser Ser Thr Thr Glu Thr
5490 5495 5500
Asn Thr Ala Phe Ser Tyr Val Pro Thr Gly Ala Ile Thr Gln Ala Ser
5505 5510 5515 5520
Arg Thr Glu Ile Ser Ser Ser Arg Thr Ser Ile Ser Asp Leu Asp Arg
5525 5530 5535
Pro Thr Ile Ala Pro Asp Ile Ser Thr Gly Met Ile Thr Arg Leu Phe
5540 5545 5550
Thr Ser Pro Ile Met Thr Lys Ser Ala Glu Met Thr Val Thr Thr Gln
5555 5560 5565
Thr Thr Thr Pro Gly Ala Thr Ser Gln Gly Ile Leu Pro Trp Asp Thr
5570 5575 5580
Ser Thr Thr Leu Phe Gln Gly Gly Thr His Ser Thr Val Ser Gln Gly
5585 5590 5595 5600
Phe Pro His Ser Glu Ile Thr Thr Leu Arg Ser Arg Thr Pro Gly Asp
5605 5610 5615
Val Ser Trp Met Thr Thr Pro Pro Val Glu Glu Thr Ser Ser Gly Phe
5620 5625 5630
Ser Leu Met Ser Pro Ser Met Thr Ser Pro Ser Pro Val Ser Ser Thr
5635 5640 5645
Ser Pro Glu Ser Ile Pro Ser Ser Pro Leu Pro Val Thr Ala Leu Leu
5650 5655 5660
Thr Ser Val Leu Val Thr Thr Thr Asn Val Leu Gly Thr Thr Ser Pro
5665 5670 5675 5680
Glu Pro Val Thr Ser Ser Pro Pro Asn Leu Ser Ser Pro Thr Gln Glu
5685 5690 5695
Arg Leu Thr Thr Tyr Lys Asp Thr Ala His Thr Glu Ala Met His Ala
5700 5705 5710
Ser Met His Thr Asn Thr Ala Val Ala Asn Val Gly Thr Ser Ile Ser
5715 5720 5725
Gly His Glu Ser Gln Ser Ser Val Pro Ala Asp Ser His Thr Ser Lys
5730 5735 5740
Ala Thr Ser Pro Met Gly Ile Thr Phe Ala Met Gly Asp Thr Ser Val
5745 5750 5755 5760
Ser Thr Ser Thr Pro Ala Phe Phe Glu Thr Arg Ile Gln Thr Glu Ser
5765 5770 5775
Thr Ser Ser Leu Ile Pro Gly Leu Arg Asp Thr Arg Thr Ser Glu Glu
5780 5785 5790
Ile Asn Thr Val Thr Glu Thr Ser Thr Val Leu Ser Glu Val Pro Thr
5795 5800 5805
Thr Thr Thr Thr Glu Val Ser Arg Thr Glu Val Ile Thr Ser Ser Arg
5810 5815 5820
Thr Thr Ile Ser Gly Pro Asp His Ser Lys Met Ser Pro Tyr Ile Ser
5825 5830 5835 5840
Thr Glu Thr Ile Thr Arg Leu Ser Thr Phe Pro Phe Val Thr Gly Ser
5845 5850 5855
Thr Glu Met Ala Ile Thr Asn Gln Thr Gly Pro Ile Gly Thr Ile Ser
5860 5865 5870
Gln Ala Thr Leu Thr Leu Asp Thr Ser Ser Thr Ala Ser Trp Glu Gly
5875 5880 5885
Thr His Ser Pro Val Thr Gln Arg Phe Pro His Ser Glu Glu Thr Thr
5890 5895 5900
Thr Met Ser Arg Ser Thr Lys Gly Val Ser Trp Gln Ser Pro Pro Ser
5905 5910 5915 5920
Val Glu Glu Thr Ser Ser Pro Ser Ser Pro Val Pro Leu Pro Ala Ile
5925 5930 5935
Thr Ser His Ser Ser Leu Tyr Ser Ala Val Ser Gly Ser Ser Pro Thr
5940 5945 5950
Ser Ala Leu Pro Val Thr Ser Leu Leu Thr Ser Gly Arg Arg Lys Thr
5955 5960 5965
Ile Asp Met Leu Asp Thr His Ser Glu Leu Val Thr Ser Ser Leu Pro
5970 5975 5980
Ser Ala Ser Ser Phe Ser Gly Glu Ile Leu Thr Ser Glu Ala Ser Thr
5985 5990 5995 6000
Asn Thr Glu Thr Ile His Phe Ser Glu Asn Thr Ala Glu Thr Asn Met
6005 6010 6015
Gly Thr Thr Asn Ser Met His Lys Leu His Ser Ser Val Ser Ile His
6020 6025 6030
Ser Gln Pro Ser Gly His Thr Pro Pro Lys Val Thr Gly Ser Met Met
6035 6040 6045
Glu Asp Ala Ile Val Ser Thr Ser Thr Pro Gly Ser Pro Glu Thr Lys
6050 6055 6060
Asn Val Asp Arg Asp Ser Thr Ser Pro Leu Thr Pro Glu Leu Lys Glu
6065 6070 6075 6080
Asp Ser Thr Ala Leu Val Met Asn Ser Thr Thr Glu Ser Asn Thr Val
6085 6090 6095
Phe Ser Ser Val Ser Leu Asp Ala Ala Thr Glu Val Ser Arg Ala Glu
6100 6105 6110
Val Thr Tyr Tyr Asp Pro Thr Phe Met Pro Ala Ser Ala Gln Ser Thr
6115 6120 6125
Lys Ser Pro Asp Ile Ser Pro Glu Ala Ser Ser Ser His Ser Asn Ser
6130 6135 6140
Pro Pro Leu Thr Ile Ser Thr His Lys Thr Ile Ala Thr Gln Thr Gly
6145 6150 6155 6160
Pro Ser Gly Val Thr Ser Leu Gly Gln Leu Thr Leu Asp Thr Ser Thr
6165 6170 6175
Ile Ala Thr Ser Ala Gly Thr Pro Ser Ala Arg Thr Gln Asp Phe Val
6180 6185 6190
Asp Ser Glu Thr Thr Ser Val Met Asn Asn Asp Leu Asn Asp Val Leu
6195 6200 6205
Lys Thr Ser Pro Phe Ser Ala Glu Glu Ala Asn Ser Leu Ser Ser Gln
6210 6215 6220
Ala Pro Leu Leu Val Thr Thr Ser Pro Ser Pro Val Thr Ser Thr Leu
6225 6230 6235 6240
Gln Glu His Ser Thr Ser Ser Leu Val Ser Val Thr Ser Val Pro Thr
6245 6250 6255
Pro Thr Leu Ala Lys Ile Thr Asp Met Asp Thr Asn Leu Glu Pro Val
6260 6265 6270
Thr Arg Ser Pro Gln Asn Leu Arg Asn Thr Leu Ala Thr Ser Glu Ala
6275 6280 6285
Thr Thr Asp Thr His Thr Met His Pro Ser Ile Asn Thr Ala Val Ala
6290 6295 6300
Asn Val Gly Thr Thr Ser Ser Pro Asn Glu Phe Tyr Phe Thr Val Ser
6305 6310 6315 6320
Pro Asp Ser Asp Pro Tyr Lys Ala Thr Ser Ala Val Val Ile Thr Ser
6325 6330 6335
Thr Ser Gly Asp Ser Ile Val Ser Thr Ser Met Pro Arg Ser Ser Ala
6340 6345 6350
Met Lys Lys Ile Glu Ser Glu Thr Thr Phe Ser Leu Ile Phe Arg Leu
6355 6360 6365
Arg Glu Thr Ser Thr Ser Gln Lys Ile Gly Ser Ser Ser Asp Thr Ser
6370 6375 6380
Thr Val Phe Asp Lys Ala Phe Thr Ala Ala Thr Thr Glu Val Ser Arg
6385 6390 6395 6400
Thr Glu Leu Thr Ser Ser Ser Arg Thr Ser Ile Gln Gly Thr Glu Lys
6405 6410 6415
Pro Thr Met Ser Pro Asp Thr Ser Thr Arg Ser Val Thr Met Leu Ser
6420 6425 6430
Thr Phe Ala Gly Leu Thr Lys Ser Glu Glu Arg Thr Ile Ala Thr Gln
6435 6440 6445
Thr Gly Pro His Arg Ala Thr Ser Gln Gly Thr Leu Thr Trp Asp Thr
6450 6455 6460
Ser Ile Thr Thr Ser Gln Ala Gly Thr His Ser Ala Met Thr His Gly
6465 6470 6475 6480
Phe Ser Gln Leu Asp Leu Ser Thr Leu Thr Ser Arg Val Pro Glu Tyr
6485 6490 6495
Ile Ser Gly Thr Ser Pro Pro Ser Val Glu Lys Thr Ser Ser Ser Ser
6500 6505 6510
Ser Leu Leu Ser Leu Pro Ala Ile Thr Ser Pro Ser Pro Val Pro Thr
6515 6520 6525
Thr Leu Pro Glu Ser Arg Pro Ser Ser Pro Val His Leu Thr Ser Leu
6530 6535 6540
Pro Thr Ser Gly Leu Val Lys Thr Thr Asp Met Leu Ala Ser Val Ala
6545 6550 6555 6560
Ser Leu Pro Pro Asn Leu Gly Ser Thr Ser His Lys Ile Pro Thr Thr
6565 6570 6575
Ser Glu Asp Ile Lys Asp Thr Glu Lys Met Tyr Pro Ser Thr Asn Ile
6580 6585 6590
Ala Val Thr Asn Val Gly Thr Thr Thr Ser Glu Lys Glu Ser Tyr Ser
6595 6600 6605
Ser Val Pro Ala Tyr Ser Glu Pro Pro Lys Val Thr Ser Pro Met Val
6610 6615 6620
Thr Ser Phe Asn Ile Arg Asp Thr Ile Val Ser Thr Ser Met Pro Gly
6625 6630 6635 6640
Ser Ser Glu Ile Thr Arg Ile Glu Met Glu Ser Thr Phe Ser Leu Ala
6645 6650 6655
His Gly Leu Lys Gly Thr Ser Thr Ser Gln Asp Pro Ile Val Ser Thr
6660 6665 6670
Glu Lys Ser Ala Val Leu His Lys Leu Thr Thr Gly Ala Thr Glu Thr
6675 6680 6685
Ser Arg Thr Glu Val Ala Ser Ser Arg Arg Thr Ser Ile Pro Gly Pro
6690 6695 6700
Asp His Ser Thr Glu Ser Pro Asp Ile Ser Thr Glu Val Ile Pro Ser
6705 6710 6715 6720
Leu Pro Ile Ser Leu Gly Ile Thr Glu Ser Ser Asn Met Thr Ile Ile
6725 6730 6735
Thr Arg Thr Gly Pro Pro Leu Gly Ser Thr Ser Gln Gly Thr Phe Thr
6740 6745 6750
Leu Asp Thr Pro Thr Thr Ser Ser Arg Ala Gly Thr His Ser Met Ala
6755 6760 6765
Thr Gln Glu Phe Pro His Ser Glu Met Thr Thr Val Met Asn Lys Asp
6770 6775 6780
Pro Glu Ile Leu Ser Trp Thr Ile Pro Pro Ser Ile Glu Lys Thr Ser
6785 6790 6795 6800
Phe Ser Ser Ser Leu Met Pro Ser Pro Ala Met Thr Ser Pro Pro Val
6805 6810 6815
Ser Ser Thr Leu Pro Lys Thr Ile His Thr Thr Pro Ser Pro Met Thr
6820 6825 6830
Ser Leu Leu Thr Pro Ser Leu Val Met Thr Thr Asp Thr Leu Gly Thr
6835 6840 6845
Ser Pro Glu Pro Thr Thr Ser Ser Pro Pro Asn Leu Ser Ser Thr Ser
6850 6855 6860
His Glu Ile Leu Thr Thr Asp Glu Asp Thr Thr Ala Ile Glu Ala Met
6865 6870 6875 6880
His Pro Ser Thr Ser Thr Ala Ala Thr Asn Val Glu Thr Thr Ser Ser
6885 6890 6895
Gly His Gly Ser Gln Ser Ser Val Leu Ala Asp Ser Glu Lys Thr Lys
6900 6905 6910
Ala Thr Ala Pro Met Asp Thr Thr Ser Thr Met Gly His Thr Thr Val
6915 6920 6925
Ser Thr Ser Met Ser Val Ser Ser Glu Thr Thr Lys Ile Lys Arg Glu
6930 6935 6940
Ser Thr Tyr Ser Leu Thr Pro Gly Leu Arg Glu Thr Ser Ile Ser Gln
6945 6950 6955 6960
Asn Ala Ser Phe Ser Thr Asp Thr Ser Ile Val Leu Ser Glu Val Pro
6965 6970 6975
Thr Gly Thr Thr Ala Glu Val Ser Arg Thr Glu Val Thr Ser Ser Gly
6980 6985 6990
Arg Thr Ser Ile Pro Gly Pro Ser Gln Ser Thr Val Leu Pro Glu Ile
6995 7000 7005
Ser Thr Arg Thr Met Thr Arg Leu Phe Ala Ser Pro Thr Met Thr Glu
7010 7015 7020
Ser Ala Glu Met Thr Ile Pro Thr Gln Thr Gly Pro Ser Gly Ser Thr
7025 7030 7035 7040
Ser Gln Asp Thr Leu Thr Leu Asp Thr Ser Thr Thr Lys Ser Gln Ala
7045 7050 7055
Lys Thr His Ser Thr Leu Thr Gln Arg Phe Pro His Ser Glu Met Thr
7060 7065 7070
Thr Leu Met Ser Arg Gly Pro Gly Asp Met Ser Trp Gln Ser Ser Pro
7075 7080 7085
Ser Leu Glu Asn Pro Ser Ser Leu Pro Ser Leu Leu Ser Leu Pro Ala
7090 7095 7100
Thr Thr Ser Pro Pro Pro Ile Ser Ser Thr Leu Pro Val Thr Ile Ser
7105 7110 7115 7120
Ser Ser Pro Leu Pro Val Thr Ser Leu Leu Thr Ser Ser Pro Val Thr
7125 7130 7135
Thr Thr Asp Met Leu His Thr Ser Pro Glu Leu Val Thr Ser Ser Pro
7140 7145 7150
Pro Lys Leu Ser His Thr Ser Asp Glu Arg Leu Thr Thr Gly Lys Asp
7155 7160 7165
Thr Thr Asn Thr Glu Ala Val His Pro Ser Thr Asn Thr Ala Ala Ser
7170 7175 7180
Asn Val Glu Ile Pro Ser Ser Gly His Glu Ser Pro Ser Ser Ala Leu
7185 7190 7195 7200
Ala Asp Ser Glu Thr Ser Lys Ala Thr Ser Pro Met Phe Ile Thr Ser
7205 7210 7215
Thr Gln Glu Asp Thr Thr Val Ala Ile Ser Thr Pro His Phe Leu Glu
7220 7225 7230
Thr Ser Arg Ile Gln Lys Glu Ser Ile Ser Ser Leu Ser Pro Lys Leu
7235 7240 7245
Arg Glu Thr Gly Ser Ser Val Glu Thr Ser Ser Ala Ile Glu Thr Ser
7250 7255 7260
Ala Val Leu Ser Glu Val Ser Ile Gly Ala Thr Thr Glu Ile Ser Arg
7265 7270 7275 7280
Thr Glu Val Thr Ser Ser Ser Arg Thr Ser Ile Ser Gly Ser Ala Glu
7285 7290 7295
Ser Thr Met Leu Pro Glu Ile Ser Thr Thr Arg Lys Ile Ile Lys Phe
7300 7305 7310
Pro Thr Ser Pro Ile Leu Ala Glu Ser Ser Glu Met Thr Ile Lys Thr
7315 7320 7325
Gln Thr Ser Pro Pro Gly Ser Thr Ser Glu Ser Thr Phe Thr Leu Asp
7330 7335 7340
Thr Ser Thr Thr Pro Ser Leu Val Ile Thr His Ser Thr Met Thr Gln
7345 7350 7355 7360
Arg Leu Pro His Ser Glu Ile Thr Thr Leu Val Ser Arg Gly Ala Gly
7365 7370 7375
Asp Val Pro Arg Pro Ser Ser Leu Pro Val Glu Glu Thr Ser Pro Pro
7380 7385 7390
Ser Ser Gln Leu Ser Leu Ser Ala Met Ile Ser Pro Ser Pro Val Ser
7395 7400 7405
Ser Thr Leu Pro Ala Ser Ser His Ser Ser Ser Ala Ser Val Thr Ser
7410 7415 7420
Leu Leu Thr Pro Gly Gln Val Lys Thr Thr Glu Val Leu Asp Ala Ser
7425 7430 7435 7440
Ala Glu Pro Glu Thr Ser Ser Pro Pro Ser Leu Ser Ser Thr Ser Val
7445 7450 7455
Glu Ile Leu Ala Thr Ser Glu Val Thr Thr Asp Thr Glu Lys Ile His
7460 7465 7470
Pro Phe Ser Asn Thr Ala Val Thr Lys Val Gly Thr Ser Ser Ser Gly
7475 7480 7485
His Glu Ser Pro Ser Ser Val Leu Pro Asp Ser Glu Thr Thr Lys Ala
7490 7495 7500
Thr Ser Ala Met Gly Thr Ile Ser Ile Met Gly Asp Thr Ser Val Ser
7505 7510 7515 7520
Thr Leu Thr Pro Ala Leu Ser Asn Thr Arg Lys Ile Gln Ser Glu Pro
7525 7530 7535
Ala Ser Ser Leu Thr Thr Arg Leu Arg Glu Thr Ser Thr Ser Glu Glu
7540 7545 7550
Thr Ser Leu Ala Thr Glu Ala Asn Thr Val Leu Ser Lys Val Ser Thr
7555 7560 7565
Gly Ala Thr Thr Glu Val Ser Arg Thr Glu Ala Ile Ser Phe Ser Arg
7570 7575 7580
Thr Ser Met Ser Gly Pro Glu Gln Ser Thr Met Ser Gln Asp Ile Ser
7585 7590 7595 7600
Ile Gly Thr Ile Pro Arg Ile Ser Ala Ser Ser Val Leu Thr Glu Ser
7605 7610 7615
Ala Lys Met Thr Ile Thr Thr Gln Thr Gly Pro Ser Glu Ser Thr Leu
7620 7625 7630
Glu Ser Thr Leu Asn Leu Asn Thr Ala Thr Thr Pro Ser Trp Val Glu
7635 7640 7645
Thr His Ser Ile Val Ile Gln Gly Phe Pro His Pro Glu Met Thr Thr
7650 7655 7660
Ser Met Gly Arg Gly Pro Gly Gly Val Ser Trp Pro Ser Pro Pro Phe
7665 7670 7675 7680
Val Lys Glu Thr Ser Pro Pro Ser Ser Pro Leu Ser Leu Pro Ala Val
7685 7690 7695
Thr Ser Pro His Pro Val Ser Thr Thr Phe Leu Ala His Ile Pro Pro
7700 7705 7710
Ser Pro Leu Pro Val Thr Ser Leu Leu Thr Ser Gly Pro Ala Thr Thr
7715 7720 7725
Thr Asp Ile Leu Gly Thr Ser Thr Glu Pro Gly Thr Ser Ser Ser Ser
7730 7735 7740
Ser Leu Ser Thr Thr Ser His Glu Arg Leu Thr Thr Tyr Lys Asp Thr
7745 7750 7755 7760
Ala His Thr Glu Ala Val His Pro Ser Thr Asn Thr Gly Gly Thr Asn
7765 7770 7775
Val Ala Thr Thr Ser Ser Gly Tyr Lys Ser Gln Ser Ser Val Leu Ala
7780 7785 7790
Asp Ser Ser Pro Met Cys Thr Thr Ser Thr Met Gly Asp Thr Ser Val
7795 7800 7805
Leu Thr Ser Thr Pro Ala Phe Leu Glu Thr Arg Arg Ile Gln Thr Glu
7810 7815 7820
Leu Ala Ser Ser Leu Thr Pro Gly Leu Arg Glu Ser Ser Gly Ser Glu
7825 7830 7835 7840
Gly Thr Ser Ser Gly Thr Lys Met Ser Thr Val Leu Ser Lys Val Pro
7845 7850 7855
Thr Gly Ala Thr Thr Glu Ile Ser Lys Glu Asp Val Thr Ser Ile Pro
7860 7865 7870
Gly Pro Ala Gln Ser Thr Ile Ser Pro Asp Ile Ser Thr Arg Thr Val
7875 7880 7885
Ser Trp Phe Ser Thr Ser Pro Val Met Thr Glu Ser Ala Glu Ile Thr
7890 7895 7900
Met Asn Thr His Thr Ser Pro Leu Gly Ala Thr Thr Gln Gly Thr Ser
7905 7910 7915 7920
Thr Leu Asp Thr Ser Ser Thr Thr Ser Leu Thr Met Thr His Ser Thr
7925 7930 7935
Ile Ser Gln Gly Phe Ser His Ser Gln Met Ser Thr Leu Met Arg Arg
7940 7945 7950
Gly Pro Glu Asp Val Ser Trp Met Ser Pro Pro Leu Leu Glu Lys Thr
7955 7960 7965
Arg Pro Ser Phe Ser Leu Met Ser Ser Pro Ala Thr Thr Ser Pro Ser
7970 7975 7980
Pro Val Ser Ser Thr Leu Pro Glu Ser Ile Ser Ser Ser Pro Leu Pro
7985 7990 7995 8000
Val Thr Ser Leu Leu Thr Ser Gly Leu Ala Lys Thr Thr Asp Met Leu
8005 8010 8015
His Lys Ser Ser Glu Pro Val Thr Asn Ser Pro Ala Asn Leu Ser Ser
8020 8025 8030
Thr Ser Val Glu Ile Leu Ala Thr Ser Glu Val Thr Thr Asp Thr Glu
8035 8040 8045
Lys Thr His Pro Ser Ser Asn Arg Thr Val Thr Asp Val Gly Thr Ser
8050 8055 8060
Ser Ser Gly His Glu Ser Thr Ser Phe Val Leu Ala Asp Ser Gln Thr
8065 8070 8075 8080
Ser Lys Val Thr Ser Pro Met Val Ile Thr Ser Thr Met Glu Asp Thr
8085 8090 8095
Ser Val Ser Thr Ser Thr Pro Gly Phe Phe Glu Thr Ser Arg Ile Gln
8100 8105 8110
Thr Glu Pro Thr Ser Ser Leu Thr Leu Gly Leu Arg Lys Thr Ser Ser
8115 8120 8125
Ser Glu Gly Thr Ser Leu Ala Thr Glu Met Ser Thr Val Leu Ser Gly
8130 8135 8140
Val Pro Thr Gly Ala Thr Ala Glu Val Ser Arg Thr Glu Val Thr Ser
8145 8150 8155 8160
Ser Ser Arg Thr Ser Ile Ser Gly Phe Ala Gln Leu Thr Val Ser Pro
8165 8170 8175
Glu Thr Ser Thr Glu Thr Ile Thr Arg Leu Pro Thr Ser Ser Ile Met
8180 8185 8190
Thr Glu Ser Ala Glu Met Met Ile Lys Thr Gln Thr Asp Pro Pro Gly
8195 8200 8205
Ser Thr Pro Glu Ser Thr His Thr Val Asp Ile Ser Thr Thr Pro Asn
8210 8215 8220
Trp Val Glu Thr His Ser Thr Val Thr Gln Arg Phe Ser His Ser Glu
8225 8230 8235 8240
Met Thr Thr Leu Val Ser Arg Ser Pro Gly Asp Met Leu Trp Pro Ser
8245 8250 8255
Gln Ser Ser Val Glu Glu Thr Ser Ser Ala Ser Ser Leu Leu Ser Leu
8260 8265 8270
Pro Ala Thr Thr Ser Pro Ser Pro Val Ser Ser Thr Leu Val Glu Asp
8275 8280 8285
Phe Pro Ser Ala Ser Leu Pro Val Thr Ser Leu Leu Asn Pro Gly Leu
8290 8295 8300
Val Ile Thr Thr Asp Arg Met Gly Ile Ser Arg Glu Pro Gly Thr Ser
8305 8310 8315 8320
Ser Thr Ser Asn Leu Ser Ser Thr Ser His Glu Arg Leu Thr Thr Leu
8325 8330 8335
Glu Asp Thr Val Asp Thr Glu Asp Met Gln Pro Ser Thr His Thr Ala
8340 8345 8350
Val Thr Asn Val Arg Thr Ser Ile Ser Gly His Glu Ser Gln Ser Ser
8355 8360 8365
Val Leu Ser Asp Ser Glu Thr Pro Lys Ala Thr Ser Pro Met Gly Thr
8370 8375 8380
Thr Tyr Thr Met Gly Glu Thr Ser Val Ser Ile Ser Thr Ser Asp Phe
8385 8390 8395 8400
Phe Glu Thr Ser Arg Ile Gln Ile Glu Pro Thr Ser Ser Leu Thr Ser
8405 8410 8415
Gly Leu Arg Glu Thr Ser Ser Ser Glu Arg Ile Ser Ser Ala Thr Glu
8420 8425 8430
Gly Ser Thr Val Leu Ser Glu Val Pro Ser Gly Ala Thr Thr Glu Val
8435 8440 8445
Ser Arg Thr Glu Val Ile Ser Ser Arg Gly Thr Ser Met Ser Gly Pro
8450 8455 8460
Asp Gln Phe Thr Ile Ser Pro Asp Ile Ser Thr Glu Ala Ile Thr Arg
8465 8470 8475 8480
Leu Ser Thr Ser Pro Ile Met Thr Glu Ser Ala Glu Ser Ala Ile Thr
8485 8490 8495
Ile Glu Thr Gly Ser Pro Gly Ala Thr Ser Glu Gly Thr Leu Thr Leu
8500 8505 8510
Asp Thr Ser Thr Thr Thr Phe Trp Ser Gly Thr His Ser Thr Ala Ser
8515 8520 8525
Pro Gly Phe Ser His Ser Glu Met Thr Thr Leu Met Ser Arg Thr Pro
8530 8535 8540
Gly Asp Val Pro Trp Pro Ser Leu Pro Ser Val Glu Glu Ala Ser Ser
8545 8550 8555 8560
Val Ser Ser Ser Leu Ser Ser Pro Ala Met Thr Ser Thr Ser Phe Phe
8565 8570 8575
Ser Thr Leu Pro Glu Ser Ile Ser Ser Ser Pro His Pro Val Thr Ala
8580 8585 8590
Leu Leu Thr Leu Gly Pro Val Lys Thr Thr Asp Met Leu Arg Thr Ser
8595 8600 8605
Ser Glu Pro Glu Thr Ser Ser Pro Pro Asn Leu Ser Ser Thr Ser Ala
8610 8615 8620
Glu Ile Leu Ala Thr Ser Glu Val Thr Lys Asp Arg Glu Lys Ile His
8625 8630 8635 8640
Pro Ser Ser Asn Thr Pro Val Val Asn Val Gly Thr Val Ile Tyr Lys
8645 8650 8655
His Leu Ser Pro Ser Ser Val Leu Ala Asp Leu Val Thr Thr Lys Pro
8660 8665 8670
Thr Ser Pro Met Ala Thr Thr Ser Thr Leu Gly Asn Thr Ser Val Ser
8675 8680 8685
Thr Ser Thr Pro Ala Phe Pro Glu Thr Met Met Thr Gln Pro Thr Ser
8690 8695 8700
Ser Leu Thr Ser Gly Leu Arg Glu Ile Ser Thr Ser Gln Glu Thr Ser
8705 8710 8715 8720
Ser Ala Thr Glu Arg Ser Ala Ser Leu Ser Gly Met Pro Thr Gly Ala
8725 8730 8735
Thr Thr Lys Val Ser Arg Thr Glu Ala Leu Ser Leu Gly Arg Thr Ser
8740 8745 8750
Thr Pro Gly Pro Ala Gln Ser Thr Ile Ser Pro Glu Ile Ser Thr Glu
8755 8760 8765
Thr Ile Thr Arg Ile Ser Thr Pro Leu Thr Thr Thr Gly Ser Ala Glu
8770 8775 8780
Met Thr Ile Thr Pro Lys Thr Gly His Ser Gly Ala Ser Ser Gln Gly
8785 8790 8795 8800
Thr Phe Thr Leu Asp Thr Ser Ser Arg Ala Ser Trp Pro Gly Thr His
8805 8810 8815
Ser Ala Ala Thr His Arg Ser Pro His Ser Gly Met Thr Thr Pro Met
8820 8825 8830
Ser Arg Gly Pro Glu Asp Val Ser Trp Pro Ser Arg Pro Ser Val Glu
8835 8840 8845
Lys Thr Ser Pro Pro Ser Ser Leu Val Ser Leu Ser Ala Val Thr Ser
8850 8855 8860
Pro Ser Pro Leu Tyr Ser Thr Pro Ser Glu Ser Ser His Ser Ser Pro
8865 8870 8875 8880
Leu Arg Val Thr Ser Leu Phe Thr Pro Val Met Met Lys Thr Thr Asp
8885 8890 8895
Met Leu Asp Thr Ser Leu Glu Pro Val Thr Thr Ser Pro Pro Ser Met
8900 8905 8910
Asn Ile Thr Ser Asp Glu Ser Leu Ala Thr Ser Lys Ala Thr Met Glu
8915 8920 8925
Thr Glu Ala Ile Gln Leu Ser Glu Asn Thr Ala Val Thr Gln Met Gly
8930 8935 8940
Thr Ile Ser Ala Arg Gln Glu Phe Tyr Ser Ser Tyr Pro Gly Leu Pro
8945 8950 8955 8960
Glu Pro Ser Lys Val Thr Ser Pro Val Val Thr Ser Ser Thr Ile Lys
8965 8970 8975
Asp Ile Val Ser Thr Thr Ile Pro Ala Ser Ser Glu Ile Thr Arg Ile
8980 8985 8990
Glu Met Glu Ser Thr Ser Thr Leu Thr Pro Thr Pro Arg Glu Thr Ser
8995 9000 9005
Thr Ser Gln Glu Ile His Ser Ala Thr Lys Pro Ser Thr Val Pro Tyr
9010 9015 9020
Lys Ala Leu Thr Ser Ala Thr Ile Glu Asp Ser Met Thr Gln Val Met
9025 9030 9035 9040
Ser Ser Ser Arg Gly Pro Ser Pro Asp Gln Ser Thr Met Ser Gln Asp
9045 9050 9055
Ile Ser Thr Glu Val Ile Thr Arg Leu Ser Thr Ser Pro Ile Lys Thr
9060 9065 9070
Glu Ser Thr Glu Met Thr Ile Thr Thr Gln Thr Gly Ser Pro Gly Ala
9075 9080 9085
Thr Ser Arg Gly Thr Leu Thr Leu Asp Thr Ser Thr Thr Phe Met Ser
9090 9095 9100
Gly Thr His Ser Thr Ala Ser Gln Gly Phe Ser His Ser Gln Met Thr
9105 9110 9115 9120
Ala Leu Met Ser Arg Thr Pro Gly Asp Val Pro Trp Leu Ser His Pro
9125 9130 9135
Ser Val Glu Glu Ala Ser Ser Ala Ser Phe Ser Leu Ser Ser Pro Val
9140 9145 9150
Met Thr Ser Ser Ser Pro Val Ser Ser Thr Leu Pro Asp Ser Ile His
9155 9160 9165
Ser Ser Ser Leu Pro Val Thr Ser Leu Leu Thr Ser Gly Leu Val Lys
9170 9175 9180
Thr Thr Glu Leu Leu Gly Thr Ser Ser Glu Pro Glu Thr Ser Ser Pro
9185 9190 9195 9200
Pro Asn Leu Ser Ser Thr Ser Ala Glu Ile Leu Ala Ile Thr Glu Val
9205 9210 9215
Thr Thr Asp Thr Glu Lys Leu Glu Met Thr Asn Val Val Thr Ser Gly
9220 9225 9230
Tyr Thr His Glu Ser Pro Ser Ser Val Leu Ala Asp Ser Val Thr Thr
9235 9240 9245
Lys Ala Thr Ser Ser Met Gly Ile Thr Tyr Pro Thr Gly Asp Thr Asn
9250 9255 9260
Val Leu Thr Ser Thr Pro Ala Phe Ser Asp Thr Ser Arg Ile Gln Thr
9265 9270 9275 9280
Lys Ser Lys Leu Ser Leu Thr Pro Gly Leu Met Glu Thr Ser Ile Ser
9285 9290 9295
Glu Glu Thr Ser Ser Ala Thr Glu Lys Ser Thr Val Leu Ser Ser Val
9300 9305 9310
Pro Thr Gly Ala Thr Thr Glu Val Ser Arg Thr Glu Ala Ile Ser Ser
9315 9320 9325
Ser Arg Thr Ser Ile Pro Gly Pro Ala Gln Ser Thr Met Ser Ser Asp
9330 9335 9340
Thr Ser Met Glu Thr Ile Thr Arg Ile Ser Thr Pro Leu Thr Arg Lys
9345 9350 9355 9360
Glu Ser Thr Asp Met Ala Ile Thr Pro Lys Thr Gly Pro Ser Gly Ala
9365 9370 9375
Thr Ser Gln Gly Thr Phe Thr Leu Asp Ser Ser Ser Thr Ala Ser Trp
9380 9385 9390
Pro Gly Thr His Ser Ala Thr Thr Gln Arg Phe Pro Gln Ser Val Val
9395 9400 9405
Thr Thr Pro Met Ser Arg Gly Pro Glu Asp Val Ser Trp Pro Ser Pro
9410 9415 9420
Leu Ser Val Glu Lys Asn Ser Pro Pro Ser Ser Leu Val Ser Ser Ser
9425 9430 9435 9440
Ser Val Thr Ser Pro Ser Pro Leu Tyr Ser Thr Pro Ser Gly Ser Ser
9445 9450 9455
His Ser Ser Pro Val Pro Val Thr Ser Leu Phe Thr Ser Ile Met Met
9460 9465 9470
Lys Ala Thr Asp Met Leu Asp Ala Ser Leu Glu Pro Glu Thr Thr Ser
9475 9480 9485
Ala Pro Asn Met Asn Ile Thr Ser Asp Glu Ser Leu Ala Ala Ser Lys
9490 9495 9500
Ala Thr Thr Glu Thr Glu Ala Ile His Val Phe Glu Asn Thr Ala Ala
9505 9510 9515 9520
Ser His Val Glu Thr Thr Ser Ala Thr Glu Glu Leu Tyr Ser Ser Ser
9525 9530 9535
Pro Gly Phe Ser Glu Pro Thr Lys Val Ile Ser Pro Val Val Thr Ser
9540 9545 9550
Ser Ser Ile Arg Asp Asn Met Val Ser Thr Thr Met Pro Gly Ser Ser
9555 9560 9565
Gly Ile Thr Arg Ile Glu Ile Glu Ser Met Ser Ser Leu Thr Pro Gly
9570 9575 9580
Leu Arg Glu Thr Arg Thr Ser Gln Asp Ile Thr Ser Ser Thr Glu Thr
9585 9590 9595 9600
Ser Thr Val Leu Tyr Lys Met Pro Ser Gly Ala Thr Pro Glu Val Ser
9605 9610 9615
Arg Thr Glu Val Met Pro Ser Ser Arg Thr Ser Ile Pro Gly Pro Ala
9620 9625 9630
Gln Ser Thr Met Ser Leu Asp Ile Ser Asp Glu Val Val Thr Arg Leu
9635 9640 9645
Ser Thr Ser Pro Ile Met Thr Glu Ser Ala Glu Ile Thr Ile Thr Thr
9650 9655 9660
Gln Thr Gly Tyr Ser Leu Ala Thr Ser Gln Val Thr Leu Pro Leu Gly
9665 9670 9675 9680
Thr Ser Met Thr Phe Leu Ser Gly Thr His Ser Thr Met Ser Gln Gly
9685 9690 9695
Leu Ser His Ser Glu Met Thr Asn Leu Met Ser Arg Gly Pro Glu Ser
9700 9705 9710
Leu Ser Trp Thr Ser Pro Arg Phe Val Glu Thr Thr Arg Ser Ser Ser
9715 9720 9725
Ser Leu Thr Ser Leu Pro Leu Thr Thr Ser Leu Ser Pro Val Ser Ser
9730 9735 9740
Thr Leu Leu Asp Ser Ser Pro Ser Ser Pro Leu Pro Val Thr Ser Leu
9745 9750 9755 9760
Ile Leu Pro Gly Leu Val Lys Thr Thr Glu Val Leu Asp Thr Ser Ser
9765 9770 9775
Glu Pro Lys Thr Ser Ser Ser Pro Asn Leu Ser Ser Thr Ser Val Glu
9780 9785 9790
Ile Pro Ala Thr Ser Glu Ile Met Thr Asp Thr Glu Lys Ile His Pro
9795 9800 9805
Ser Ser Asn Thr Ala Val Ala Lys Val Arg Thr Ser Ser Ser Val His
9810 9815 9820
Glu Ser His Ser Ser Val Leu Ala Asp Ser Glu Thr Thr Ile Thr Ile
9825 9830 9835 9840
Pro Ser Met Gly Ile Thr Ser Ala Val Asp Asp Thr Thr Val Phe Thr
9845 9850 9855
Ser Asn Pro Ala Phe Ser Glu Thr Arg Arg Ile Pro Thr Glu Pro Thr
9860 9865 9870
Phe Ser Leu Thr Pro Gly Phe Arg Glu Thr Ser Thr Ser Glu Glu Thr
9875 9880 9885
Thr Ser Ile Thr Glu Thr Ser Ala Val Leu Tyr Gly Val Pro Thr Ser
9890 9895 9900
Ala Thr Thr Glu Val Ser Met Thr Glu Ile Met Ser Ser Asn Arg Ile
9905 9910 9915 9920
His Ile Pro Asp Ser Asp Gln Ser Thr Met Ser Pro Asp Ile Ile Thr
9925 9930 9935
Glu Val Ile Thr Arg Leu Ser Ser Ser Ser Met Met Ser Glu Ser Thr
9940 9945 9950
Gln Met Thr Ile Thr Thr Gln Lys Ser Ser Pro Gly Ala Thr Ala Gln
9955 9960 9965
Ser Thr Leu Thr Leu Ala Thr Thr Thr Ala Pro Leu Ala Arg Thr His
9970 9975 9980
Ser Thr Val Pro Pro Arg Phe Leu His Ser Glu Met Thr Thr Leu Met
9985 9990 9995 10000
Ser Arg Ser Pro Glu Asn Pro Ser Trp Lys Ser Ser Leu Phe Val Glu
10005 10010 10015
Lys Thr Ser Ser Ser Ser Ser Leu Leu Ser Leu Pro Val Thr Thr Ser
10020 10025 10030
Pro Ser Val Ser Ser Thr Leu Pro Gln Ser Ile Pro Ser Ser Ser Phe
10035 10040 10045
Ser Val Thr Ser Leu Leu Thr Pro Gly Met Val Lys Thr Thr Asp Thr
10050 10055 10060
Ser Thr Glu Pro Gly Thr Ser Leu Ser Pro Asn Leu Ser Gly Thr Ser
10065 10070 10075 10080
Val Glu Ile Leu Ala Ala Ser Glu Val Thr Thr Asp Thr Glu Lys Ile
10085 10090 10095
His Pro Ser Ser Ser Met Ala Val Thr Asn Val Gly Thr Thr Ser Ser
10100 10105 10110
Gly His Glu Leu Tyr Ser Ser Val Ser Ile His Ser Glu Pro Ser Lys
10115 10120 10125
Ala Thr Tyr Pro Val Gly Thr Pro Ser Ser Met Ala Glu Thr Ser Ile
10130 10135 10140
Ser Thr Ser Met Pro Ala Asn Phe Glu Thr Thr Gly Phe Glu Ala Glu
10145 10150 10155 10160
Pro Phe Ser His Leu Thr Ser Gly Phe Arg Lys Thr Asn Met Ser Leu
10165 10170 10175
Asp Thr Ser Ser Val Thr Pro Thr Asn Thr Pro Ser Ser Pro Gly Ser
10180 10185 10190
Thr His Leu Leu Gln Ser Ser Lys Thr Asp Phe Thr Ser Ser Ala Lys
10195 10200 10205
Thr Ser Ser Pro Asp Trp Pro Pro Ala Ser Gln Tyr Thr Glu Ile Pro
10210 10215 10220
Val Asp Ile Ile Thr Pro Phe Asn Ala Ser Pro Ser Ile Thr Glu Ser
10225 10230 10235 10240
Thr Gly Ile Thr Ser Phe Pro Glu Ser Arg Phe Thr Met Ser Val Thr
10245 10250 10255
Glu Ser Thr His His Leu Ser Thr Asp Leu Leu Pro Ser Ala Glu Thr
10260 10265 10270
Ile Ser Thr Gly Thr Val Met Pro Ser Leu Ser Glu Ala Met Thr Ser
10275 10280 10285
Phe Ala Thr Thr Gly Val Pro Arg Ala Ile Ser Gly Ser Gly Ser Pro
10290 10295 10300
Phe Ser Arg Thr Glu Ser Gly Pro Gly Asp Ala Thr Leu Ser Thr Ile
10305 10310 10315 10320
Ala Glu Ser Leu Pro Ser Ser Thr Pro Val Pro Phe Ser Ser Ser Thr
10325 10330 10335
Phe Thr Thr Thr Asp Ser Ser Thr Ile Pro Ala Leu His Glu Ile Thr
10340 10345 10350
Ser Ser Ser Ala Thr Pro Tyr Arg Val Asp Thr Ser Leu Gly Thr Glu
10355 10360 10365
Ser Ser Thr Thr Glu Gly Arg Leu Val Met Val Ser Thr Leu Asp Thr
10370 10375 10380
Ser Ser Gln Pro Gly Arg Thr Ser Ser Ser Pro Ile Leu Asp Thr Arg
10385 10390 10395 10400
Met Thr Glu Ser Val Glu Leu Gly Thr Val Thr Ser Ala Tyr Gln Val
10405 10410 10415
Pro Ser Leu Ser Thr Arg Leu Thr Arg Thr Asp Gly Ile Met Glu His
10420 10425 10430
Ile Thr Lys Ile Pro Asn Glu Ala Ala His Arg Gly Thr Ile Arg Pro
10435 10440 10445
Val Lys Gly Pro Gln Thr Ser Thr Ser Pro Ala Ser Pro Lys Gly Leu
10450 10455 10460
His Thr Gly Gly Thr Lys Arg Met Glu Thr Thr Thr Thr Ala Leu Lys
10465 10470 10475 10480
Thr Thr Thr Thr Ala Leu Lys Thr Thr Ser Arg Ala Thr Leu Thr Thr
10485 10490 10495
Ser Val Tyr Thr Pro Thr Leu Gly Thr Leu Thr Pro Leu Asn Ala Ser
10500 10505 10510
Met Gln Met Ala Ser Thr Ile Pro Thr Glu Met Met Ile Thr Thr Pro
10515 10520 10525
Tyr Val Phe Pro Asp Val Pro Glu Thr Thr Ser Ser Leu Ala Thr Ser
10530 10535 10540
Leu Gly Ala Glu Thr Ser Thr Ala Leu Pro Arg Thr Thr Pro Ser Val
10545 10550 10555 10560
Phe Asn Arg Glu Ser Glu Thr Thr Ala Ser Leu Val Ser Arg Ser Gly
10565 10570 10575
Ala Glu Arg Ser Pro Val Ile Gln Thr Leu Asp Val Ser Ser Ser Glu
10580 10585 10590
Pro Asp Thr Thr Ala Ser Trp Val Ile His Pro Ala Glu Thr Ile Pro
10595 10600 10605
Thr Val Ser Lys Thr Thr Pro Asn Phe Phe His Ser Glu Leu Asp Thr
10610 10615 10620
Val Ser Ser Thr Ala Thr Ser His Gly Ala Asp Val Ser Ser Ala Ile
10625 10630 10635 10640
Pro Thr Asn Ile Ser Pro Ser Glu Leu Asp Ala Leu Thr Pro Leu Val
10645 10650 10655
Thr Ile Ser Gly Thr Asp Thr Ser Thr Thr Phe Pro Thr Leu Thr Lys
10660 10665 10670
Ser Pro His Glu Thr Glu Thr Arg Thr Thr Trp Leu Thr His Pro Ala
10675 10680 10685
Glu Thr Ser Ser Thr Ile Pro Arg Thr Ile Pro Asn Phe Ser His His
10690 10695 10700
Glu Ser Asp Ala Thr Pro Ser Ile Ala Thr Ser Pro Gly Ala Glu Thr
10705 10710 10715 10720
Ser Ser Ala Ile Pro Ile Met Thr Val Ser Pro Gly Ala Glu Asp Leu
10725 10730 10735
Val Thr Ser Gln Val Thr Ser Ser Gly Thr Asp Arg Asn Met Thr Ile
10740 10745 10750
Pro Thr Leu Thr Leu Ser Pro Gly Glu Pro Lys Thr Ile Ala Ser Leu
10755 10760 10765
Val Thr His Pro Glu Ala Gln Thr Ser Ser Ala Ile Pro Thr Ser Thr
10770 10775 10780
Ile Ser Pro Ala Val Ser Arg Leu Val Thr Ser Met Val Thr Ser Leu
10785 10790 10795 10800
Ala Ala Lys Thr Ser Thr Thr Asn Arg Ala Leu Thr Asn Ser Pro Gly
10805 10810 10815
Glu Pro Ala Thr Thr Val Ser Leu Val Thr His Pro Ala Gln Thr Ser
10820 10825 10830
Pro Thr Val Pro Trp Thr Thr Ser Ile Phe Phe His Ser Lys Ser Asp
10835 10840 10845
Thr Thr Pro Ser Met Thr Thr Ser His Gly Ala Glu Ser Ser Ser Ala
10850 10855 10860
Val Pro Thr Pro Thr Val Ser Thr Glu Val Pro Gly Val Val Thr Pro
10865 10870 10875 10880
Leu Val Thr Ser Ser Arg Ala Val Ile Ser Thr Thr Ile Pro Ile Leu
10885 10890 10895
Thr Leu Ser Pro Gly Glu Pro Glu Thr Thr Pro Ser Met Ala Thr Ser
10900 10905 10910
His Gly Glu Glu Ala Ser Ser Ala Ile Pro Thr Pro Thr Val Ser Pro
10915 10920 10925
Gly Val Pro Gly Val Val Thr Ser Leu Val Thr Ser Ser Arg Ala Val
10930 10935 10940
Thr Ser Thr Thr Ile Pro Ile Leu Thr Phe Ser Leu Gly Glu Pro Glu
10945 10950 10955 10960
Thr Thr Pro Ser Met Ala Thr Ser His Gly Thr Glu Ala Gly Ser Ala
10965 10970 10975
Val Pro Thr Val Leu Pro Glu Val Pro Gly Met Val Thr Ser Leu Val
10980 10985 10990
Ala Ser Ser Arg Ala Val Thr Ser Thr Thr Leu Pro Thr Leu Thr Leu
10995 11000 11005
Ser Pro Gly Glu Pro Glu Thr Thr Pro Ser Met Ala Thr Ser His Gly
11010 11015 11020
Ala Glu Ala Ser Ser Thr Val Pro Thr Val Ser Pro Glu Val Pro Gly
11025 11030 11035 11040
Val Val Thr Ser Leu Val Thr Ser Ser Ser Gly Val Asn Ser Thr Ser
11045 11050 11055
Ile Pro Thr Leu Ile Leu Ser Pro Gly Glu Leu Glu Thr Thr Pro Ser
11060 11065 11070
Met Ala Thr Ser His Gly Ala Glu Ala Ser Ser Ala Val Pro Thr Pro
11075 11080 11085
Thr Val Ser Pro Gly Val Ser Gly Val Val Thr Pro Leu Val Thr Ser
11090 11095 11100
Ser Arg Ala Val Thr Ser Thr Thr Ile Pro Ile Leu Thr Leu Ser Ser
11105 11110 11115 11120
Ser Glu Pro Glu Thr Thr Pro Ser Met Ala Thr Ser His Gly Val Glu
11125 11130 11135
Ala Ser Ser Ala Val Leu Thr Val Ser Pro Glu Val Pro Gly Met Val
11140 11145 11150
Thr Ser Leu Val Thr Ser Ser Arg Ala Val Thr Ser Thr Thr Ile Pro
11155 11160 11165
Thr Leu Thr Ile Ser Ser Asp Glu Pro Glu Thr Thr Thr Ser Leu Val
11170 11175 11180
Thr His Ser Glu Ala Lys Met Ile Ser Ala Ile Pro Thr Leu Ala Val
11185 11190 11195 11200
Ser Pro Thr Val Gln Gly Leu Val Thr Ser Leu Val Thr Ser Ser Gly
11205 11210 11215
Ser Glu Thr Ser Ala Phe Ser Asn Leu Thr Val Ala Ser Ser Gln Pro
11220 11225 11230
Glu Thr Ile Asp Ser Trp Val Ala His Pro Gly Thr Glu Ala Ser Ser
11235 11240 11245
Val Val Pro Thr Leu Thr Val Ser Thr Gly Glu Pro Phe Thr Asn Ile
11250 11255 11260
Ser Leu Val Thr His Pro Ala Glu Ser Ser Ser Thr Leu Pro Arg Thr
11265 11270 11275 11280
Thr Ser Arg Phe Ser His Ser Glu Leu Asp Thr Met Pro Ser Thr Val
11285 11290 11295
Thr Ser Pro Glu Ala Glu Ser Ser Ser Ala Ile Ser Thr Thr Ile Ser
11300 11305 11310
Pro Gly Ile Pro Gly Val Leu Thr Ser Leu Val Thr Ser Ser Gly Arg
11315 11320 11325
Asp Ile Ser Ala Thr Phe Pro Thr Val Pro Glu Ser Pro His Glu Ser
11330 11335 11340
Glu Ala Thr Ala Ser Trp Val Thr His Pro Ala Val Thr Ser Thr Thr
11345 11350 11355 11360
Val Pro Arg Thr Thr Pro Asn Tyr Ser His Ser Glu Pro Asp Thr Thr
11365 11370 11375
Pro Ser Ile Ala Thr Ser Pro Gly Ala Glu Ala Thr Ser Asp Phe Pro
11380 11385 11390
Thr Ile Thr Val Ser Pro Asp Val Pro Asp Met Val Thr Ser Gln Val
11395 11400 11405
Thr Ser Ser Gly Thr Asp Thr Ser Ile Thr Ile Pro Thr Leu Thr Leu
11410 11415 11420
Ser Ser Gly Glu Pro Glu Thr Thr Thr Ser Phe Ile Thr Tyr Ser Glu
11425 11430 11435 11440
Thr His Thr Ser Ser Ala Ile Pro Thr Leu Pro Val Ser Pro Gly Ala
11445 11450 11455
Ser Lys Met Leu Thr Ser Leu Val Ile Ser Ser Gly Thr Asp Ser Thr
11460 11465 11470
Thr Thr Phe Pro Thr Leu Thr Glu Thr Pro Tyr Glu Pro Glu Thr Thr
11475 11480 11485
Ala Ile Gln Leu Ile His Pro Ala Glu Thr Asn Thr Met Val Pro Arg
11490 11495 11500
Thr Thr Pro Lys Phe Ser His Ser Lys Ser Asp Thr Thr Leu Pro Val
11505 11510 11515 11520
Ala Ile Thr Ser Pro Gly Pro Glu Ala Ser Ser Ala Val Ser Thr Thr
11525 11530 11535
Thr Ile Ser Pro Asp Met Ser Asp Leu Val Thr Ser Leu Val Pro Ser
11540 11545 11550
Ser Gly Thr Asp Thr Ser Thr Thr Phe Pro Thr Leu Ser Glu Thr Pro
11555 11560 11565
Tyr Glu Pro Glu Thr Thr Ala Thr Trp Leu Thr His Pro Ala Glu Thr
11570 11575 11580
Ser Thr Thr Val Ser Gly Thr Ile Pro Asn Phe Ser His Arg Gly Ser
11585 11590 11595 11600
Asp Thr Ala Pro Ser Met Val Thr Ser Pro Gly Val Asp Thr Arg Ser
11605 11610 11615
Gly Val Pro Thr Thr Thr Ile Pro Pro Ser Ile Pro Gly Val Val Thr
11620 11625 11630
Ser Gln Val Thr Ser Ser Ala Thr Asp Thr Ser Thr Ala Ile Pro Thr
11635 11640 11645
Leu Thr Pro Ser Pro Gly Glu Pro Glu Thr Thr Ala Ser Ser Ala Thr
11650 11655 11660
His Pro Gly Thr Gln Thr Gly Phe Thr Val Pro Ile Arg Thr Val Pro
11665 11670 11675 11680
Ser Ser Glu Pro Asp Thr Met Ala Ser Trp Val Thr His Pro Pro Gln
11685 11690 11695
Thr Ser Thr Pro Val Ser Arg Thr Thr Ser Ser Phe Ser His Ser Ser
11700 11705 11710
Pro Asp Ala Thr Pro Val Met Ala Thr Ser Pro Arg Thr Glu Ala Ser
11715 11720 11725
Ser Ala Val Leu Thr Thr Ile Ser Pro Gly Ala Pro Glu Met Val Thr
11730 11735 11740
Ser Gln Ile Thr Ser Ser Gly Ala Ala Thr Ser Thr Thr Val Pro Thr
11745 11750 11755 11760
Leu Thr His Ser Pro Gly Met Pro Glu Thr Thr Ala Leu Leu Ser Thr
11765 11770 11775
His Pro Arg Thr Glu Thr Ser Lys Thr Phe Pro Ala Ser Thr Val Phe
11780 11785 11790
Pro Gln Val Ser Glu Thr Thr Ala Ser Leu Thr Ile Arg Pro Gly Ala
11795 11800 11805
Glu Thr Ser Thr Ala Leu Pro Thr Gln Thr Thr Ser Ser Leu Phe Thr
11810 11815 11820
Leu Leu Val Thr Gly Thr Ser Arg Val Asp Leu Ser Pro Thr Ala Ser
11825 11830 11835 11840
Pro Gly Val Ser Ala Lys Thr Ala Pro Leu Ser Thr His Pro Gly Thr
11845 11850 11855
Glu Thr Ser Thr Met Ile Pro Thr Ser Thr Leu Ser Leu Gly Leu Leu
11860 11865 11870
Glu Thr Thr Gly Leu Leu Ala Thr Ser Ser Ser Ala Glu Thr Ser Thr
11875 11880 11885
Ser Thr Leu Thr Leu Thr Val Ser Pro Ala Val Ser Gly Leu Ser Ser
11890 11895 11900
Ala Ser Ile Thr Thr Asp Lys Pro Gln Thr Val Thr Ser Trp Asn Thr
11905 11910 11915 11920
Glu Thr Ser Pro Ser Val Thr Ser Val Gly Pro Pro Glu Phe Ser Arg
11925 11930 11935
Thr Val Thr Gly Thr Thr Met Thr Leu Ile Pro Ser Glu Met Pro Thr
11940 11945 11950
Pro Pro Lys Thr Ser His Gly Glu Gly Val Ser Pro Thr Thr Ile Leu
11955 11960 11965
Arg Thr Thr Met Val Glu Ala Thr Asn Leu Ala Thr Thr Gly Ser Ser
11970 11975 11980
Pro Thr Val Ala Lys Thr Thr Thr Thr Phe Asn Thr Leu Ala Gly Ser
11985 11990 11995 12000
Leu Phe Thr Pro Leu Thr Thr Pro Gly Met Ser Thr Leu Ala Ser Glu
12005 12010 12015
Ser Val Thr Ser Arg Thr Ser Tyr Asn His Arg Ser Trp Ile Ser Thr
12020 12025 12030
Thr Ser Ser Tyr Asn Arg Arg Tyr Trp Thr Pro Ala Thr Ser Thr Pro
12035 12040 12045
Val Thr Ser Thr Phe Ser Pro Gly Ile Ser Thr Ser Ser Ile Pro Ser
12050 12055 12060
Ser Thr Ala Ala Thr Val Pro Phe Met Val Pro Phe Thr Leu Asn Phe
12065 12070 12075 12080
Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met Arg His Pro Gly Ser
12085 12090 12095
Arg Lys Phe Asn Ala Thr Glu Arg Glu Leu Gln Gly Leu Leu Lys Pro
12100 12105 12110
Leu Phe Arg Asn Ser Ser Leu Glu Tyr Leu Tyr Ser Gly Cys Arg Leu
12115 12120 12125
Ala Ser Leu Arg Pro Glu Lys Asp Ser Ser Ala Thr Ala Val Asp Ala
12130 12135 12140
Ile Cys Thr His Arg Pro Asp Pro Glu Asp Leu Gly Leu Asp Arg Glu
12145 12150 12155 12160
Arg Leu Tyr Trp Glu Leu Ser Asn Leu Thr Asn Gly Ile Gln Glu Leu
12165 12170 12175
Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr
12180 12185 12190
His Arg Ser Ser Met Pro Thr Thr Ser Thr Pro Gly Thr Ser Thr Val
12195 12200 12205
Asp Val Gly Thr Ser Gly Thr Pro Ser Ser Ser Pro Ser Pro Thr Thr
12210 12215 12220
Ala Gly Pro Leu Leu Met Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn
12225 12230 12235 12240
Leu Gln Tyr Glu Glu Asp Met Arg Arg Thr Gly Ser Arg Lys Phe Asn
12245 12250 12255
Thr Met Glu Ser Val Leu Gln Gly Leu Leu Lys Pro Leu Phe Lys Asn
12260 12265 12270
Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg
12275 12280 12285
Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr His
12290 12295 12300
Arg Leu Asp Pro Lys Ser Pro Gly Leu Asn Arg Glu Gln Leu Tyr Trp
12305 12310 12315 12320
Glu Leu Ser Lys Leu Thr Asn Asp Ile Glu Glu Leu Gly Pro Tyr Thr
12325 12330 12335
Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Gln Ser Ser
12340 12345 12350
Val Ser Thr Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Arg Thr
12355 12360 12365
Ser Gly Thr Pro Ser Ser Leu Ser Ser Pro Thr Ile Met Ala Ala Gly
12370 12375 12380
Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln
12385 12390 12395 12400
Tyr Gly Glu Asp Met Gly His Pro Gly Ser Arg Lys Phe Asn Thr Thr
12405 12410 12415
Glu Arg Val Leu Gln Gly Leu Leu Gly Pro Ile Phe Lys Asn Thr Ser
12420 12425 12430
Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Ser Leu Arg Ser Glu
12435 12440 12445
Lys Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Ile His His Leu
12450 12455 12460
Asp Pro Lys Ser Pro Gly Leu Asn Arg Glu Arg Leu Tyr Trp Glu Leu
12465 12470 12475 12480
Ser Gln Leu Thr Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp
12485 12490 12495
Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Thr Ser Val Pro
12500 12505 12510
Thr Ser Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly Thr Ser Gly
12515 12520 12525
Thr Pro Phe Ser Leu Pro Ser Pro Ala Thr Ala Gly Pro Leu Leu Val
12530 12535 12540
Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Lys Tyr Glu Glu Asp
12545 12550 12555 12560
Met His Arg Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu
12565 12570 12575
Gln Thr Leu Leu Gly Pro Met Phe Lys Asn Thr Ser Val Gly Leu Leu
12580 12585 12590
Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Ser Glu Lys Asp Gly Ala
12595 12600 12605
Ala Thr Gly Val Asp Ala Ile Cys Thr His Arg Leu Asp Pro Lys Ser
12610 12615 12620
Pro Gly Val Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr
12625 12630 12635 12640
Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu
12645 12650 12655
Tyr Val Asn Gly Phe Thr His Trp Ile Pro Val Pro Thr Ser Ser Thr
12660 12665 12670
Pro Gly Thr Ser Thr Val Asp Leu Gly Ser Gly Thr Pro Ser Ser Leu
12675 12680 12685
Pro Ser Pro Thr Thr Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn
12690 12695 12700
Phe Thr Ile Thr Asn Leu Lys Tyr Glu Glu Asp Met His Cys Pro Gly
12705 12710 12715 12720
Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Ser Leu Leu Gly
12725 12730 12735
Pro Met Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg
12740 12745 12750
Leu Thr Leu Leu Arg Ser Glu Lys Asp Gly Ala Ala Thr Gly Val Asp
12755 12760 12765
Ala Ile Cys Thr His Arg Leu Asp Pro Lys Ser Pro Gly Val Asp Arg
12770 12775 12780
Glu Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr Asn Gly Ile Lys Glu
12785 12790 12795 12800
Leu Gly Pro Tyr Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe
12805 12810 12815
Thr His Gln Thr Ser Ala Pro Asn Thr Ser Thr Pro Gly Thr Ser Thr
12820 12825 12830
Val Asp Leu Gly Thr Ser Gly Thr Pro Ser Ser Leu Pro Ser Pro Thr
12835 12840 12845
Ser Ala Gly Pro Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr
12850 12855 12860
Asn Leu Gln Tyr Glu Glu Asp Met His His Pro Gly Ser Arg Lys Phe
12865 12870 12875 12880
Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Gly Pro Met Phe Lys
12885 12890 12895
Asn Thr Ser Val Gly Leu Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu
12900 12905 12910
Arg Pro Glu Lys Asn Gly Ala Ala Thr Gly Met Asp Ala Ile Cys Ser
12915 12920 12925
His Arg Leu Asp Pro Lys Ser Pro Gly Leu Asn Arg Glu Gln Leu Tyr
12930 12935 12940
Trp Glu Leu Ser Gln Leu Thr His Gly Ile Lys Glu Leu Gly Pro Tyr
12945 12950 12955 12960
Thr Leu Asp Arg Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser
12965 12970 12975
Ser Val Ala Pro Thr Ser Thr Pro Gly Thr Ser Thr Val Asp Leu Gly
12980 12985 12990
Thr Ser Gly Thr Pro Ser Ser Leu Pro Ser Pro Thr Thr Ala Val Pro
12995 13000 13005
Leu Leu Val Pro Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr
13010 13015 13020
Gly Glu Asp Met Arg His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu
13025 13030 13035 13040
Arg Val Leu Gln Gly Leu Leu Gly Pro Leu Phe Lys Asn Ser Ser Val
13045 13050 13055
Gly Pro Leu Tyr Ser Gly Cys Arg Leu Ile Ser Leu Arg Ser Glu Lys
13060 13065 13070
Asp Gly Ala Ala Thr Gly Val Asp Ala Ile Cys Thr His His Leu Asn
13075 13080 13085
Pro Gln Ser Pro Gly Leu Asp Arg Glu Gln Leu Tyr Trp Gln Leu Ser
13090 13095 13100
Gln Met Thr Asn Gly Ile Lys Glu Leu Gly Pro Tyr Thr Leu Asp Arg
13105 13110 13115 13120
Asn Ser Leu Tyr Val Asn Gly Phe Thr His Arg Ser Ser Gly Leu Thr
13125 13130 13135
Thr Ser Thr Pro Trp Thr Ser Thr Val Asp Leu Gly Thr Ser Gly Thr
13140 13145 13150
Pro Ser Pro Val Pro Ser Pro Thr Thr Thr Gly Pro Leu Leu Val Pro
13155 13160 13165
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asn Met
13170 13175 13180
Gly His Pro Gly Ser Arg Lys Phe Asn Ile Thr Glu Ser Val Leu Gln
13185 13190 13195 13200
Gly Leu Leu Lys Pro Leu Phe Lys Ser Thr Ser Val Gly Pro Leu Tyr
13205 13210 13215
Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Val Ala
13220 13225 13230
Thr Arg Val Asp Ala Ile Cys Thr His Arg Pro Asp Pro Lys Ile Pro
13235 13240 13245
Gly Leu Asp Arg Gln Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His
13250 13255 13260
Ser Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr
13265 13270 13275 13280
Val Asn Gly Phe Thr Gln Arg Ser Ser Val Pro Thr Thr Ser Thr Pro
13285 13290 13295
Gly Thr Phe Thr Val Gln Pro Glu Thr Ser Glu Thr Pro Ser Ser Leu
13300 13305 13310
Pro Gly Pro Thr Ala Thr Gly Pro Val Leu Leu Pro Phe Thr Leu Asn
13315 13320 13325
Phe Thr Ile Thr Asn Leu Gln Tyr Glu Glu Asp Met Arg Arg Pro Gly
13330 13335 13340
Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Met
13345 13350 13355 13360
Pro Leu Phe Lys Asn Thr Ser Val Ser Ser Leu Tyr Ser Gly Cys Arg
13365 13370 13375
Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Arg Val Asp
13380 13385 13390
Ala Val Cys Thr His Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg
13395 13400 13405
Glu Arg Leu Tyr Trp Lys Leu Ser Gln Leu Thr His Gly Ile Thr Glu
13410 13415 13420
Leu Gly Pro Tyr Thr Leu Asp Arg His Ser Leu Tyr Val Asn Gly Phe
13425 13430 13435 13440
Thr His Gln Ser Ser Met Thr Thr Thr Arg Thr Pro Asp Thr Ser Thr
13445 13450 13455
Met His Leu Ala Thr Ser Arg Thr Pro Ala Ser Leu Ser Gly Pro Met
13460 13465 13470
Thr Ala Ser Pro Leu Leu Val Leu Phe Thr Ile Asn Phe Thr Ile Thr
13475 13480 13485
Asn Leu Arg Tyr Glu Glu Asn Met His His Pro Gly Ser Arg Lys Phe
13490 13495 13500
Asn Thr Thr Glu Arg Val Leu Gln Gly Leu Leu Arg Pro Val Phe Lys
13505 13510 13515 13520
Asn Thr Ser Val Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu
13525 13530 13535
Arg Pro Lys Lys Asp Gly Ala Ala Thr Lys Val Asp Ala Ile Cys Thr
13540 13545 13550
Tyr Arg Pro Asp Pro Lys Ser Pro Gly Leu Asp Arg Glu Gln Leu Tyr
13555 13560 13565
Trp Glu Leu Ser Gln Leu Thr His Ser Ile Thr Glu Leu Gly Pro Tyr
13570 13575 13580
Thr Leu Asp Arg Asp Ser Leu Tyr Val Asn Gly Phe Thr Gln Arg Ser
13585 13590 13595 13600
Ser Val Pro Thr Thr Ser Ile Pro Gly Thr Pro Thr Val Asp Leu Gly
13605 13610 13615
Thr Ser Gly Thr Pro Val Ser Lys Pro Gly Pro Ser Ala Ala Ser Pro
13620 13625 13630
Leu Leu Val Leu Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr
13635 13640 13645
Glu Glu Asn Met Gln His Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu
13650 13655 13660
Arg Val Leu Gln Gly Leu Leu Arg Ser Leu Phe Lys Ser Thr Ser Val
13665 13670 13675 13680
Gly Pro Leu Tyr Ser Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys
13685 13690 13695
Asp Gly Thr Ala Thr Gly Val Asp Ala Ile Cys Thr His His Pro Asp
13700 13705 13710
Pro Lys Ser Pro Arg Leu Asp Arg Glu Gln Leu Tyr Trp Glu Leu Ser
13715 13720 13725
Gln Leu Thr His Asn Ile Thr Glu Leu Gly Pro Tyr Ala Leu Asp Asn
13730 13735 13740
Asp Ser Leu Phe Val Asn Gly Phe Thr His Arg Ser Ser Val Ser Thr
13745 13750 13755 13760
Thr Ser Thr Pro Gly Thr Pro Thr Val Tyr Leu Gly Ala Ser Lys Thr
13765 13770 13775
Pro Ala Ser Ile Phe Gly Pro Ser Ala Ala Ser His Leu Leu Ile Leu
13780 13785 13790
Phe Thr Leu Asn Phe Thr Ile Thr Asn Leu Arg Tyr Glu Glu Asn Met
13795 13800 13805
Trp Pro Gly Ser Arg Lys Phe Asn Thr Thr Glu Arg Val Leu Gln Gly
13810 13815 13820
Leu Leu Arg Pro Leu Phe Lys Asn Thr Ser Val Gly Pro Leu Tyr Ser
13825 13830 13835 13840
Gly Cys Arg Leu Thr Leu Leu Arg Pro Glu Lys Asp Gly Glu Ala Thr
13845 13850 13855
Gly Val Asp Ala Ile Cys Thr His Arg Pro Asp Pro Thr Gly Pro Gly
13860 13865 13870
Leu Asp Arg Glu Gln Leu Tyr Leu Glu Leu Ser Gln Leu Thr His Ser
13875 13880 13885
Ile Thr Glu Leu Gly Pro Tyr Thr Leu Asp Arg Asp Ser Leu Tyr Val
13890 13895 13900
Asn Gly Phe Thr His Arg Ser Ser Val Pro Thr Thr Ser Thr Gly Val
13905 13910 13915 13920
Val Ser Glu Glu Pro Phe Thr Leu Asn Phe Thr Ile Asn Asn Leu Arg
13925 13930 13935
Tyr Met Ala Asp Met Gly Gln Pro Gly Ser Leu Lys Phe Asn Ile Thr
13940 13945 13950
Asp Asn Val Met Gln His Leu Leu Ser Pro Leu Phe Gln Arg Ser Ser
13955 13960 13965
Leu Gly Ala Arg Tyr Thr Gly Cys Arg Val Ile Ala Leu Arg Ser Val
13970 13975 13980
Lys Asn Gly Ala Glu Thr Arg Val Asp Leu Leu Cys Thr Tyr Leu Gln
13985 13990 13995 14000
Pro Leu Ser Gly Pro Gly Leu Pro Ile Lys Gln Val Phe His Glu Leu
14005 14010 14015
Ser Gln Gln Thr His Gly Ile Thr Arg Leu Gly Pro Tyr Ser Leu Asp
14020 14025 14030
Lys Asp Ser Leu Tyr Leu Asn Gly Tyr Asn Glu Pro Gly Pro Asp Glu
14035 14040 14045
Pro Pro Thr Thr Pro Lys Pro Ala Thr Thr Phe Leu Pro Pro Leu Ser
14050 14055 14060
Glu Ala Thr Thr Ala Met Gly Tyr His Leu Lys Thr Leu Thr Leu Asn
14065 14070 14075 14080
Phe Thr Ile Ser Asn Leu Gln Tyr Ser Pro Asp Met Gly Lys Gly Ser
14085 14090 14095
Ala Thr Phe Asn Ser Thr Glu Gly Val Leu Gln His Leu Leu Arg Pro
14100 14105 14110
Leu Phe Gln Lys Ser Ser Met Gly Pro Phe Tyr Leu Gly Cys Gln Leu
14115 14120 14125
Ile Ser Leu Arg Pro Glu Lys Asp Gly Ala Ala Thr Gly Val Asp Thr
14130 14135 14140
Thr Cys Thr Tyr His Pro Asp Pro Val Gly Pro Gly Leu Asp Ile Gln
14145 14150 14155 14160
Gln Leu Tyr Trp Glu Leu Ser Gln Leu Thr His Gly Val Thr Gln Leu
14165 14170 14175
Gly Phe Tyr Val Leu Asp Arg Asp Ser Leu Phe Ile Asn Gly Tyr Ala
14180 14185 14190
Pro Gln Asn Leu Ser Ile Arg Gly Glu Tyr Gln Ile Asn Phe His Ile
14195 14200 14205
Val Asn Trp Asn Leu Ser Asn Pro Asp Pro Thr Ser Ser Glu Tyr Ile
14210 14215 14220
Thr Leu Leu Arg Asp Ile Gln Asp Lys Val Thr Thr Leu Tyr Lys Gly
14225 14230 14235 14240
Ser Gln Leu His Asp Thr Phe Arg Phe Cys Leu Val Thr Asn Leu Thr
14245 14250 14255
Met Asp Ser Val Leu Val Thr Val Lys Ala Leu Phe Ser Ser Asn Leu
14260 14265 14270
Asp Pro Ser Leu Val Glu Gln Val Phe Leu Asp Lys Thr Leu Asn Ala
14275 14280 14285
Ser Phe His Trp Leu Gly Ser Thr Tyr Gln Leu Val Asp Ile His Val
14290 14295 14300
Thr Glu Met Glu Ser Ser Val Tyr Gln Pro Thr Ser Ser Ser Ser Thr
14305 14310 14315 14320
Gln His Phe Tyr Leu Asn Phe Thr Ile Thr Asn Leu Pro Tyr Ser Gln
14325 14330 14335
Asp Lys Ala Gln Pro Gly Thr Thr Asn Tyr Gln Arg Asn Lys Arg Asn
14340 14345 14350
Ile Glu Asp Ala Leu Asn Gln Leu Phe Arg Asn Ser Ser Ile Lys Ser
14355 14360 14365
Tyr Phe Ser Asp Cys Gln Val Ser Thr Phe Arg Ser Val Pro Asn Arg
14370 14375 14380
His His Thr Gly Val Asp Ser Leu Cys Asn Phe Ser Pro Leu Ala Arg
14385 14390 14395 14400
Arg Val Asp Arg Val Ala Ile Tyr Glu Glu Phe Leu Arg Met Thr Arg
14405 14410 14415
Asn Gly Thr Gln Leu Gln Asn Phe Thr Leu Asp Arg Ser Ser Val Leu
14420 14425 14430
Val Asp Gly Tyr Ser Pro Asn Arg Asn Glu Pro Leu Thr Gly Asn Ser
14435 14440 14445
Asp Leu Pro Phe Trp Ala Val Ile Leu Ile Gly Leu Ala Gly Leu Leu
14450 14455 14460
Gly Val Ile Thr Cys Leu Ile Cys Gly Val Leu Val Thr Thr Arg Arg
14465 14470 14475 14480
Arg Lys Lys Glu Gly Glu Tyr Asn Val Gln Gln Gln Cys Pro Gly Tyr
14485 14490 14495
Tyr Gln Ser His Leu Asp Leu Glu Asp Leu Gln
14500 14505
<210> 107
<211> 267
<212> PRT
<213> 智人（Homo sapiens）
<400> 107
Met Met Ser Ser Lys Pro Thr Ser His Ala Glu Val Asn Glu Thr Ile
1 5 10 15
Pro Asn Pro Tyr Pro Pro Ser Ser Phe Met Ala Pro Gly Phe Gln Gln
20 25 30
Pro Leu Gly Ser Ile Asn Leu Glu Asn Gln Ala Gln Gly Ala Gln Arg
35 40 45
Ala Gln Pro Tyr Gly Ile Thr Ser Pro Gly Ile Phe Ala Ser Ser Gln
50 55 60
Pro Gly Gln Gly Asn Ile Gln Met Ile Asn Pro Ser Val Gly Thr Ala
65 70 75 80
Val Met Asn Phe Lys Glu Glu Ala Lys Ala Leu Gly Val Ile Gln Ile
85 90 95
Met Val Gly Leu Met His Ile Gly Phe Gly Ile Val Leu Cys Leu Ile
100 105 110
Ser Phe Ser Phe Arg Glu Val Leu Gly Phe Ala Ser Thr Ala Val Ile
115 120 125
Gly Gly Tyr Pro Phe Trp Gly Gly Leu Ser Phe Ile Ile Ser Gly Ser
130 135 140
Leu Ser Val Ser Ala Ser Lys Glu Leu Ser Arg Cys Leu Val Lys Gly
145 150 155 160
Ser Leu Gly Met Asn Ile Val Ser Ser Ile Leu Ala Phe Ile Gly Val
165 170 175
Ile Leu Leu Leu Val Asp Met Cys Ile Asn Gly Val Ala Gly Gln Asp
180 185 190
Tyr Trp Ala Val Leu Ser Gly Lys Gly Ile Ser Ala Thr Leu Met Ile
195 200 205
Phe Ser Leu Leu Glu Phe Phe Val Ala Cys Ala Thr Ala His Phe Ala
210 215 220
Asn Gln Ala Asn Thr Thr Thr Asn Met Ser Val Leu Val Ile Pro Asn
225 230 235 240
Met Tyr Glu Ser Asn Pro Val Thr Pro Ala Ser Ser Ser Ala Pro Pro
245 250 255
Arg Cys Asn Asn Tyr Ser Ala Asn Ala Pro Lys
260 265
<210> 108
<211> 535
<212> PRT
<213> 智人（Homo sapiens）
<400> 108
Met Leu Gly Pro Cys Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg
1 5 10 15
Leu Gln Leu Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp
20 25 30
Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu
35 40 45
Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp
50 55 60
Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln
65 70 75 80
Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe
85 90 95
Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro
100 105 110
Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn
115 120 125
Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn
130 135 140
Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys
145 150 155 160
Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala
165 170 175
Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser
180 185 190
Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile
195 200 205
Ala Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly
210 215 220
Gly Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro
225 230 235 240
Asp Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val
245 250 255
Gln Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg
260 265 270
Thr Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met
275 280 285
Gly Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser
290 295 300
Thr Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu
305 310 315 320
Leu Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg
325 330 335
Ile Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu
340 345 350
Thr Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser
355 360 365
Glu Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe
370 375 380
Ser Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala
385 390 395 400
Pro Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly
405 410 415
Asn Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr
420 425 430
Glu Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro
435 440 445
Leu Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg
450 455 460
Gly Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile
465 470 475 480
Ala His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys
485 490 495
Asp Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Arg
500 505 510
Ser Val Val Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu
515 520 525
Leu Glu Thr Ala Thr Ala Pro
530 535
<210> 109
<211> 520
<212> PRT
<213> 智人（Homo sapiens）
<400> 109
Met Glu Phe His Asn Gly Gly His Val Ser Gly Ile Gly Gly Phe Leu
1 5 10 15
Val Ser Leu Thr Ser Arg Met Lys Pro His Thr Leu Ala Val Thr Pro
20 25 30
Ala Leu Ile Phe Ala Ile Thr Val Ala Thr Ile Gly Ser Phe Gln Phe
35 40 45
Gly Tyr Asn Thr Gly Val Ile Asn Ala Pro Glu Thr Ile Ile Lys Glu
50 55 60
Phe Ile Asn Lys Thr Leu Thr Asp Lys Ala Asn Ala Pro Pro Ser Glu
65 70 75 80
Val Leu Leu Thr Asn Leu Trp Ser Leu Ser Val Ala Ile Phe Ser Val
85 90 95
Gly Gly Met Ile Gly Ser Phe Ser Val Gly Leu Phe Val Asn Arg Phe
100 105 110
Gly Arg Arg Asn Ser Met Leu Ile Val Asn Leu Leu Ala Ala Thr Gly
115 120 125
Gly Cys Leu Met Gly Leu Cys Lys Ile Ala Glu Ser Val Glu Met Leu
130 135 140
Ile Leu Gly Arg Leu Val Ile Gly Leu Phe Cys Gly Leu Cys Thr Gly
145 150 155 160
Phe Val Pro Met Tyr Ile Gly Glu Ile Ser Pro Thr Ala Leu Arg Gly
165 170 175
Ala Phe Gly Thr Leu Asn Gln Leu Gly Ile Val Ile Gly Ile Leu Val
180 185 190
Ala Gln Ile Phe Gly Leu Glu Leu Ile Leu Gly Ser Glu Glu Leu Trp
195 200 205
Pro Val Leu Leu Gly Phe Thr Ile Leu Pro Ala Ile Leu Gln Ser Ala
210 215 220
Ala Leu Pro Cys Cys Pro Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg
225 230 235 240
Lys Lys Glu Glu Asn Ala Thr Arg Ile Leu Gln Arg Leu Trp Gly Thr
245 250 255
Gln Asp Val Ser Gln Asp Ile Gln Glu Met Lys Asp Glu Ser Ala Arg
260 265 270
Met Ser Gln Glu Lys Gln Val Thr Val Leu Glu Leu Phe Arg Val Ser
275 280 285
Ser Tyr Arg Gln Pro Ile Ile Ile Ser Ile Val Leu Gln Leu Ser Gln
290 295 300
Gln Leu Ser Gly Ile Asn Ala Val Phe Tyr Tyr Ser Thr Gly Ile Phe
305 310 315 320
Lys Asp Ala Gly Val Gln Gln Pro Ile Tyr Ala Thr Ile Ser Ala Gly
325 330 335
Val Val Asn Thr Ile Phe Thr Leu Leu Ser Leu Phe Leu Val Glu Arg
340 345 350
Ala Gly Arg Arg Thr Leu His Met Ile Gly Leu Gly Gly Met Ala Phe
355 360 365
Cys Ser Thr Leu Met Thr Val Ser Leu Leu Leu Lys Asn His Tyr Asn
370 375 380
Gly Met Ser Phe Val Cys Ile Gly Ala Ile Leu Val Phe Val Ala Cys
385 390 395 400
Phe Glu Ile Gly Pro Gly Pro Ile Pro Trp Phe Ile Val Ala Glu Leu
405 410 415
Phe Ser Gln Gly Pro Arg Pro Ala Ala Met Ala Val Ala Gly Cys Ser
420 425 430
Asn Trp Thr Ser Asn Phe Leu Val Gly Leu Leu Phe Pro Ser Ala Ala
435 440 445
Tyr Tyr Leu Gly Ala Tyr Val Phe Ile Ile Phe Thr Gly Phe Leu Ile
450 455 460
Thr Phe Leu Ala Phe Thr Phe Phe Lys Val Pro Glu Thr Arg Gly Arg
465 470 475 480
Thr Phe Glu Asp Ile Thr Arg Ala Phe Glu Gly Gln Ala His Gly Ala
485 490 495
Asp Arg Ser Gly Lys Asp Gly Val Met Gly Met Asn Ser Ile Glu Pro
500 505 510
Ala Lys Glu Thr Thr Thr Asn Val
515 520
<210> 110
<211> 221
<212> PRT
<213> 智人（Homo sapiens）
<400> 110
Met Leu Thr Leu Glu Asp Lys Asp Met Lys Gly Phe Ser Trp Ala Ile
1 5 10 15
Val Pro Ala Leu Thr Ser Leu Gly Tyr Leu Ile Ile Leu Val Val Ser
20 25 30
Ile Phe Pro Phe Trp Val Arg Leu Thr Asn Glu Glu Ser His Glu Val
35 40 45
Phe Phe Ser Gly Leu Phe Glu Asn Cys Phe Asn Ala Lys Cys Trp Lys
50 55 60
Pro Arg Pro Leu Ser Ile Tyr Ile Ile Leu Gly Arg Val Phe Leu Leu
65 70 75 80
Ser Ala Val Phe Leu Ala Phe Val Thr Thr Phe Ile Met Met Pro Phe
85 90 95
Ala Ser Glu Phe Phe Pro Arg Thr Trp Lys Gln Asn Phe Val Leu Ala
100 105 110
Cys Ile Ser Phe Phe Thr Gly Ala Cys Ala Phe Leu Ala Leu Val Leu
115 120 125
His Ala Leu Glu Ile Lys Ala Leu Arg Met Lys Leu Gly Pro Leu Gln
130 135 140
Phe Ser Val Leu Trp Pro Tyr Tyr Val Leu Gly Phe Gly Ile Phe Leu
145 150 155 160
Phe Ile Val Ala Gly Thr Ile Cys Leu Ile Gln Glu Met Val Cys Pro
165 170 175
Cys Trp His Leu Leu Ser Thr Ser Gln Ser Met Glu Glu Asp His Gly
180 185 190
Ser Leu Tyr Leu Asp Asn Leu Glu Ser Leu Gly Gly Glu Pro Ser Ser
195 200 205
Val Gln Lys Glu Thr Gln Val Thr Ala Glu Thr Val Ile
210 215 220
<210> 111
<211> 538
<212> PRT
<213> 智人（Homo sapiens）
<400> 111
Met Gly Leu Leu Leu Leu Val Leu Ile Leu Thr Pro Ser Leu Ala Ala
1 5 10 15
Tyr Arg His Pro Asp Phe Pro Leu Leu Glu Lys Ala Gln Gln Leu Leu
20 25 30
Gln Ser Thr Gly Ser Pro Tyr Ser Thr Asn Cys Trp Leu Cys Thr Ser
35 40 45
Ser Ser Thr Glu Thr Pro Gly Thr Ala Tyr Pro Ala Ser Pro Arg Glu
50 55 60
Trp Thr Ser Ile Glu Ala Glu Leu His Ile Ser Tyr Arg Trp Asp Pro
65 70 75 80
Asn Leu Lys Gly Leu Met Arg Pro Ala Asn Ser Leu Leu Ser Thr Val
85 90 95
Lys Gln Asp Phe Pro Asp Ile Arg Gln Lys Pro Pro Ile Phe Gly Pro
100 105 110
Ile Phe Thr Asn Ile Asn Leu Met Gly Ile Ala Pro Ile Cys Val Met
115 120 125
Ala Lys Arg Lys Asn Gly Thr Asn Val Gly Thr Leu Pro Ser Thr Val
130 135 140
Cys Asn Val Thr Phe Thr Val Asp Ser Asn Gln Gln Thr Tyr Gln Thr
145 150 155 160
Tyr Thr His Asn Gln Phe Arg His Gln Pro Arg Phe Pro Lys Pro Pro
165 170 175
Asn Ile Thr Phe Pro Gln Gly Thr Leu Leu Asp Lys Ser Ser Arg Phe
180 185 190
Cys Gln Gly Arg Pro Ser Ser Cys Ser Thr Arg Asn Phe Trp Phe Arg
195 200 205
Pro Ala Asp Tyr Asn Gln Cys Leu Gln Ile Ser Asn Leu Ser Ser Thr
210 215 220
Ala Glu Trp Val Leu Leu Asp Gln Thr Arg Asn Ser Leu Phe Trp Glu
225 230 235 240
Asn Lys Thr Lys Gly Ala Asn Gln Ser Gln Thr Pro Cys Val Gln Val
245 250 255
Leu Ala Gly Met Thr Ile Ala Thr Ser Tyr Leu Gly Ile Ser Ala Val
260 265 270
Ser Glu Phe Phe Gly Thr Ser Leu Thr Pro Leu Phe His Phe His Ile
275 280 285
Ser Thr Cys Leu Lys Thr Gln Gly Ala Phe Tyr Ile Cys Gly Gln Ser
290 295 300
Ile His Gln Cys Leu Pro Ser Asn Trp Thr Gly Thr Cys Thr Ile Gly
305 310 315 320
Tyr Val Thr Pro Asp Ile Phe Ile Ala Pro Gly Asn Leu Ser Leu Pro
325 330 335
Ile Pro Ile Tyr Gly Asn Ser Pro Leu Pro Arg Val Arg Arg Ala Ile
340 345 350
His Phe Ile Pro Leu Leu Ala Gly Leu Gly Ile Leu Ala Gly Thr Gly
355 360 365
Thr Gly Ile Ala Gly Ile Thr Lys Ala Ser Leu Thr Tyr Ser Gln Leu
370 375 380
Ser Lys Glu Ile Ala Asn Asn Ile Asp Thr Met Ala Lys Ala Leu Thr
385 390 395 400
Thr Met Gln Glu Gln Ile Asp Ser Leu Ala Ala Val Val Leu Gln Asn
405 410 415
Arg Arg Gly Leu Asp Met Leu Thr Ala Ala Gln Gly Gly Ile Cys Leu
420 425 430
Ala Leu Asp Glu Lys Cys Cys Phe Trp Val Asn Gln Ser Gly Lys Val
435 440 445
Gln Asp Asn Ile Arg Gln Leu Leu Asn Gln Ala Ser Ser Leu Arg Glu
450 455 460
Arg Ala Thr Gln Gly Trp Leu Asn Trp Glu Gly Thr Trp Lys Trp Phe
465 470 475 480
Ser Trp Val Leu Pro Leu Thr Gly Pro Leu Val Ser Leu Leu Leu Leu
485 490 495
Leu Leu Phe Gly Pro Cys Leu Leu Asn Leu Ile Thr Gln Phe Val Ser
500 505 510
Ser Arg Leu Gln Ala Ile Lys Leu Gln Thr Asn Leu Ser Ala Gly Arg
515 520 525
His Pro Arg Asn Ile Gln Glu Ser Pro Phe
530 535
<210> 112
<211> 1017
<212> PRT
<213> 智人（Homo sapiens）
<400> 112
Met Val Phe Ser Val Arg Gln Cys Gly His Val Gly Arg Thr Glu Glu
1 5 10 15
Val Leu Leu Thr Phe Lys Ile Phe Leu Val Ile Ile Cys Leu His Val
20 25 30
Val Leu Val Thr Ser Leu Glu Glu Asp Thr Asp Asn Ser Ser Leu Ser
35 40 45
Pro Pro Pro Ala Lys Leu Ser Val Val Ser Phe Ala Pro Ser Ser Asn
50 55 60
Gly Thr Pro Glu Val Glu Thr Thr Ser Leu Asn Asp Val Thr Leu Ser
65 70 75 80
Leu Leu Pro Ser Asn Glu Thr Glu Lys Thr Lys Ile Thr Ile Val Lys
85 90 95
Thr Phe Asn Ala Ser Gly Val Lys Pro Gln Arg Asn Ile Cys Asn Leu
100 105 110
Ser Ser Ile Cys Asn Asp Ser Ala Phe Phe Arg Gly Glu Ile Met Phe
115 120 125
Gln Tyr Asp Lys Glu Ser Thr Val Pro Gln Asn Gln His Ile Thr Asn
130 135 140
Gly Thr Leu Thr Gly Val Leu Ser Leu Ser Glu Leu Lys Arg Ser Glu
145 150 155 160
Leu Asn Lys Thr Leu Gln Thr Leu Ser Glu Thr Tyr Phe Ile Met Cys
165 170 175
Ala Thr Ala Glu Ala Gln Ser Thr Leu Asn Cys Thr Phe Thr Ile Lys
180 185 190
Leu Asn Asn Thr Met Asn Ala Cys Ala Val Ile Ala Ala Leu Glu Arg
195 200 205
Val Lys Ile Arg Pro Met Glu His Cys Cys Cys Ser Val Arg Ile Pro
210 215 220
Cys Pro Ser Ser Pro Glu Glu Leu Glu Lys Leu Gln Cys Asp Leu Gln
225 230 235 240
Asp Pro Ile Val Cys Leu Ala Asp His Pro Arg Gly Pro Pro Phe Ser
245 250 255
Ser Ser Gln Ser Ile Pro Val Val Pro Arg Ala Thr Val Leu Ser Gln
260 265 270
Val Pro Lys Ala Thr Ser Phe Ala Glu Pro Pro Asp Tyr Ser Pro Val
275 280 285
Thr His Asn Val Pro Ser Pro Ile Gly Glu Ile Gln Pro Leu Ser Pro
290 295 300
Gln Pro Ser Ala Pro Ile Ala Ser Ser Pro Ala Ile Asp Met Pro Pro
305 310 315 320
Gln Ser Glu Thr Ile Ser Ser Pro Met Pro Gln Thr His Val Ser Gly
325 330 335
Thr Pro Pro Pro Val Lys Ala Ser Phe Ser Ser Pro Thr Val Ser Ala
340 345 350
Pro Ala Asn Val Asn Thr Thr Ser Ala Pro Pro Val Gln Thr Asp Ile
355 360 365
Val Asn Thr Ser Ser Ile Ser Asp Leu Glu Asn Gln Val Leu Gln Met
370 375 380
Glu Lys Ala Leu Ser Leu Gly Ser Leu Glu Pro Asn Leu Ala Gly Glu
385 390 395 400
Met Ile Asn Gln Val Ser Arg Leu Leu His Ser Pro Pro Asp Met Leu
405 410 415
Ala Pro Leu Ala Gln Arg Leu Leu Lys Val Val Asp Asp Ile Gly Leu
420 425 430
Gln Leu Asn Phe Ser Asn Thr Thr Ile Ser Leu Thr Ser Pro Ser Leu
435 440 445
Ala Leu Ala Val Ile Arg Val Asn Ala Ser Ser Phe Asn Thr Thr Thr
450 455 460
Phe Val Ala Gln Asp Pro Ala Asn Leu Gln Val Ser Leu Glu Thr Gln
465 470 475 480
Ala Pro Glu Asn Ser Ile Gly Thr Ile Thr Leu Pro Ser Ser Leu Met
485 490 495
Asn Asn Leu Pro Ala His Asp Met Glu Leu Ala Ser Arg Val Gln Phe
500 505 510
Asn Phe Phe Glu Thr Pro Ala Leu Phe Gln Asp Pro Ser Leu Glu Asn
515 520 525
Leu Ser Leu Ile Ser Tyr Val Ile Ser Ser Ser Val Ala Asn Leu Thr
530 535 540
Val Arg Asn Leu Thr Arg Asn Val Thr Val Thr Leu Lys His Ile Asn
545 550 555 560
Pro Ser Gln Asp Glu Leu Thr Val Arg Cys Val Phe Trp Asp Leu Gly
565 570 575
Arg Asn Gly Gly Arg Gly Gly Trp Ser Asp Asn Gly Cys Ser Val Lys
580 585 590
Asp Arg Arg Leu Asn Glu Thr Ile Cys Thr Cys Ser His Leu Thr Ser
595 600 605
Phe Gly Val Leu Leu Asp Leu Ser Arg Thr Ser Val Leu Pro Ala Gln
610 615 620
Met Met Ala Leu Thr Phe Ile Thr Tyr Ile Gly Cys Gly Leu Ser Ser
625 630 635 640
Ile Phe Leu Ser Val Thr Leu Val Thr Tyr Ile Ala Phe Glu Lys Ile
645 650 655
Arg Arg Asp Tyr Pro Ser Lys Ile Leu Ile Gln Leu Cys Ala Ala Leu
660 665 670
Leu Leu Leu Asn Leu Val Phe Leu Leu Asp Ser Trp Ile Ala Leu Tyr
675 680 685
Lys Met Gln Gly Leu Cys Ile Ser Val Ala Val Phe Leu His Tyr Phe
690 695 700
Leu Leu Val Ser Phe Thr Trp Met Gly Leu Glu Ala Phe His Met Tyr
705 710 715 720
Leu Ala Leu Val Lys Val Phe Asn Thr Tyr Ile Arg Lys Tyr Ile Leu
725 730 735
Lys Phe Cys Ile Val Gly Trp Gly Val Pro Ala Val Val Val Thr Ile
740 745 750
Ile Leu Thr Ile Ser Pro Asp Asn Tyr Gly Leu Gly Ser Tyr Gly Lys
755 760 765
Phe Pro Asn Gly Ser Pro Asp Asp Phe Cys Trp Ile Asn Asn Asn Ala
770 775 780
Val Phe Tyr Ile Thr Val Val Gly Tyr Phe Cys Val Ile Phe Leu Leu
785 790 795 800
Asn Val Ser Met Phe Ile Val Val Leu Val Gln Leu Cys Arg Ile Lys
805 810 815
Lys Lys Lys Gln Leu Gly Ala Gln Arg Lys Thr Ser Ile Gln Asp Leu
820 825 830
Arg Ser Ile Ala Gly Leu Thr Phe Leu Leu Gly Ile Thr Trp Gly Phe
835 840 845
Ala Phe Phe Ala Trp Gly Pro Val Asn Val Thr Phe Met Tyr Leu Phe
850 855 860
Ala Ile Phe Asn Thr Leu Gln Gly Phe Phe Ile Phe Ile Phe Tyr Cys
865 870 875 880
Val Ala Lys Glu Asn Val Arg Lys Gln Trp Arg Arg Tyr Leu Cys Cys
885 890 895
Gly Lys Leu Arg Leu Ala Glu Asn Ser Asp Trp Ser Lys Thr Ala Thr
900 905 910
Asn Gly Leu Lys Lys Gln Thr Val Asn Gln Gly Val Ser Ser Ser Ser
915 920 925
Asn Ser Leu Gln Ser Ser Ser Asn Ser Thr Asn Ser Thr Thr Leu Leu
930 935 940
Val Asn Asn Asp Cys Ser Val His Ala Ser Gly Asn Gly Asn Ala Ser
945 950 955 960
Thr Glu Arg Asn Gly Val Ser Phe Ser Val Gln Asn Gly Asp Val Cys
965 970 975
Leu His Asp Phe Thr Gly Lys Gln His Met Phe Asn Glu Lys Glu Asp
980 985 990
Ser Cys Asn Gly Lys Gly Arg Met Ala Leu Arg Arg Thr Ser Lys Arg
995 1000 1005
Gly Ser Leu His Phe Ile Glu Gln Met
1010 1015
<210> 113
<211> 775
<212> PRT
<213> 智人（Homo sapiens）
<400> 113
Met Glu Pro Pro Tyr Ser Leu Thr Ala His Tyr Asp Glu Phe Gln Glu
1 5 10 15
Val Lys Tyr Val Ser Arg Cys Gly Ala Gly Gly Ala Arg Gly Ala Ser
20 25 30
Leu Pro Pro Gly Phe Pro Leu Gly Ala Ala Arg Ser Ala Thr Gly Ala
35 40 45
Arg Ser Gly Leu Pro Arg Trp Asn Arg Arg Glu Val Cys Leu Leu Ser
50 55 60
Gly Leu Val Phe Ala Ala Gly Leu Cys Ala Ile Leu Ala Ala Met Leu
65 70 75 80
Ala Leu Lys Tyr Leu Gly Pro Val Ala Ala Gly Gly Gly Ala Cys Pro
85 90 95
Glu Gly Cys Pro Glu Arg Lys Ala Phe Ala Arg Ala Ala Arg Phe Leu
100 105 110
Ala Ala Asn Leu Asp Ala Ser Ile Asp Pro Cys Gln Asp Phe Tyr Ser
115 120 125
Phe Ala Cys Gly Gly Trp Leu Arg Arg His Ala Ile Pro Asp Asp Lys
130 135 140
Leu Thr Tyr Gly Thr Ile Ala Ala Ile Gly Glu Gln Asn Glu Glu Arg
145 150 155 160
Leu Arg Arg Leu Leu Ala Arg Pro Gly Gly Gly Pro Gly Gly Ala Ala
165 170 175
Gln Arg Lys Val Arg Ala Phe Phe Arg Ser Cys Leu Asp Met Arg Glu
180 185 190
Ile Glu Arg Leu Gly Pro Arg Pro Met Leu Glu Val Ile Glu Asp Cys
195 200 205
Gly Gly Trp Asp Leu Gly Gly Ala Glu Glu Arg Pro Gly Val Ala Ala
210 215 220
Arg Trp Asp Leu Asn Arg Leu Leu Tyr Lys Ala Gln Gly Val Tyr Ser
225 230 235 240
Ala Ala Ala Leu Phe Ser Leu Thr Val Ser Leu Asp Asp Arg Asn Ser
245 250 255
Ser Arg Tyr Val Ile Arg Ile Asp Gln Asp Gly Leu Thr Leu Pro Glu
260 265 270
Arg Thr Leu Tyr Leu Ala Gln Asp Glu Asp Ser Glu Lys Ile Leu Ala
275 280 285
Ala Tyr Arg Val Phe Met Glu Arg Val Leu Ser Leu Leu Gly Ala Asp
290 295 300
Ala Val Glu Gln Lys Ala Gln Glu Ile Leu Gln Val Glu Gln Gln Leu
305 310 315 320
Ala Asn Ile Thr Val Ser Glu His Asp Asp Leu Arg Arg Asp Val Ser
325 330 335
Ser Met Tyr Asn Lys Val Thr Leu Gly Gln Leu Gln Lys Ile Thr Pro
340 345 350
His Leu Arg Trp Lys Trp Leu Leu Asp Gln Ile Phe Gln Glu Asp Phe
355 360 365
Ser Glu Glu Glu Glu Val Val Leu Leu Ala Thr Asp Tyr Met Gln Gln
370 375 380
Val Ser Gln Leu Ile Arg Ser Thr Pro His Arg Val Leu His Asn Tyr
385 390 395 400
Leu Val Trp Arg Val Val Val Val Leu Ser Glu His Leu Ser Pro Pro
405 410 415
Phe Arg Glu Ala Leu His Glu Leu Ala Gln Glu Met Glu Gly Ser Asp
420 425 430
Lys Pro Gln Glu Leu Ala Arg Val Cys Leu Gly Gln Ala Asn Arg His
435 440 445
Phe Gly Met Ala Leu Gly Ala Leu Phe Val His Glu His Phe Ser Ala
450 455 460
Ala Ser Lys Ala Lys Val Gln Gln Leu Val Glu Asp Ile Lys Tyr Ile
465 470 475 480
Leu Gly Gln Arg Leu Glu Glu Leu Asp Trp Met Asp Ala Glu Thr Arg
485 490 495
Ala Ala Ala Arg Ala Lys Leu Gln Tyr Met Met Val Met Val Gly Tyr
500 505 510
Pro Asp Phe Leu Leu Lys Pro Asp Ala Val Asp Lys Glu Tyr Glu Phe
515 520 525
Glu Val His Glu Lys Thr Tyr Phe Lys Asn Ile Leu Asn Ser Ile Arg
530 535 540
Phe Ser Ile Gln Leu Ser Val Lys Lys Ile Arg Gln Glu Val Asp Lys
545 550 555 560
Ser Thr Trp Leu Leu Pro Pro Gln Ala Leu Asn Ala Tyr Tyr Leu Pro
565 570 575
Asn Lys Asn Gln Met Val Phe Pro Ala Gly Ile Leu Gln Pro Thr Leu
580 585 590
Tyr Asp Pro Asp Phe Pro Gln Ser Leu Asn Tyr Gly Gly Ile Gly Thr
595 600 605
Ile Ile Gly His Glu Leu Thr His Gly Tyr Asp Asp Trp Gly Gly Gln
610 615 620
Tyr Asp Arg Ser Gly Asn Leu Leu His Trp Trp Thr Glu Ala Ser Tyr
625 630 635 640
Ser Arg Phe Leu Arg Lys Ala Glu Cys Ile Val Arg Leu Tyr Asp Asn
645 650 655
Phe Thr Val Tyr Asn Gln Arg Val Asn Gly Lys His Thr Leu Gly Glu
660 665 670
Asn Ile Ala Asp Met Gly Gly Leu Lys Leu Ala Tyr His Ala Tyr Gln
675 680 685
Lys Trp Val Arg Glu His Gly Pro Glu His Pro Leu Pro Arg Leu Lys
690 695 700
Tyr Thr His Asp Gln Leu Phe Phe Ile Ala Phe Ala Gln Asn Trp Cys
705 710 715 720
Ile Lys Arg Arg Ser Gln Ser Ile Tyr Leu Gln Val Leu Thr Asp Lys
725 730 735
His Ala Pro Glu His Tyr Arg Val Leu Gly Ser Val Ser Gln Phe Glu
740 745 750
Glu Phe Gly Arg Ala Phe His Cys Pro Lys Asp Ser Pro Met Asn Pro
755 760 765
Ala His Lys Cys Ser Val Trp
770 775
<210> 114
<211> 529
<212> PRT
<213> 智人（Homo sapiens）
<400> 114
Met Gly Pro Ser Cys Pro Val Phe Leu Ser Phe Thr Lys Leu Ser Leu
1 5 10 15
Trp Trp Leu Leu Leu Thr Pro Ala Gly Gly Glu Glu Ala Lys Arg Pro
20 25 30
Pro Pro Arg Ala Pro Gly Asp Pro Leu Ser Ser Pro Ser Pro Thr Ala
35 40 45
Leu Pro Gln Gly Gly Ser His Thr Glu Thr Glu Asp Arg Leu Phe Lys
50 55 60
His Leu Phe Arg Gly Tyr Asn Arg Trp Ala Arg Pro Val Pro Asn Thr
65 70 75 80
Ser Asp Val Val Ile Val Arg Phe Gly Leu Ser Ile Ala Gln Leu Ile
85 90 95
Asp Val Asp Glu Lys Asn Gln Met Met Thr Thr Asn Val Trp Leu Lys
100 105 110
Gln Glu Trp Ser Asp Tyr Lys Leu Arg Trp Asn Pro Thr Asp Phe Gly
115 120 125
Asn Ile Thr Ser Leu Arg Val Pro Ser Glu Met Ile Trp Ile Pro Asp
130 135 140
Ile Val Leu Tyr Asn Asn Ala Asp Gly Glu Phe Ala Val Thr His Met
145 150 155 160
Thr Lys Ala His Leu Phe Ser Thr Gly Thr Val His Trp Val Pro Pro
165 170 175
Ala Ile Tyr Lys Ser Ser Cys Ser Ile Asp Val Thr Phe Phe Pro Phe
180 185 190
Asp Gln Gln Asn Cys Lys Met Lys Phe Gly Ser Trp Thr Tyr Asp Lys
195 200 205
Ala Lys Ile Asp Leu Glu Gln Met Glu Gln Thr Val Asp Leu Lys Asp
210 215 220
Tyr Trp Glu Ser Gly Glu Trp Ala Ile Val Asn Ala Thr Gly Thr Tyr
225 230 235 240
Asn Ser Lys Lys Tyr Asp Cys Cys Ala Glu Ile Tyr Pro Asp Val Thr
245 250 255
Tyr Ala Phe Val Ile Arg Arg Leu Pro Leu Phe Tyr Thr Ile Asn Leu
260 265 270
Ile Ile Pro Cys Leu Leu Ile Ser Cys Leu Thr Val Leu Val Phe Tyr
275 280 285
Leu Pro Ser Asp Cys Gly Glu Lys Ile Thr Leu Cys Ile Ser Val Leu
290 295 300
Leu Ser Leu Thr Val Phe Leu Leu Leu Ile Thr Glu Ile Ile Pro Ser
305 310 315 320
Thr Ser Leu Val Ile Pro Leu Ile Gly Glu Tyr Leu Leu Phe Thr Met
325 330 335
Ile Phe Val Thr Leu Ser Ile Val Ile Thr Val Phe Val Leu Asn Val
340 345 350
His His Arg Ser Pro Ser Thr His Thr Met Pro His Trp Val Arg Gly
355 360 365
Ala Leu Leu Gly Cys Val Pro Arg Trp Leu Leu Met Asn Arg Pro Pro
370 375 380
Pro Pro Val Glu Leu Cys His Pro Leu Arg Leu Lys Leu Ser Pro Ser
385 390 395 400
Tyr His Trp Leu Glu Ser Asn Val Asp Ala Glu Glu Arg Glu Val Val
405 410 415
Val Glu Glu Glu Asp Arg Trp Ala Cys Ala Gly His Val Ala Pro Ser
420 425 430
Val Gly Thr Leu Cys Ser His Gly His Leu His Ser Gly Ala Ser Gly
435 440 445
Pro Lys Ala Glu Ala Leu Leu Gln Glu Gly Glu Leu Leu Leu Ser Pro
450 455 460
His Met Gln Lys Ala Leu Glu Gly Val His Tyr Ile Ala Asp His Leu
465 470 475 480
Arg Ser Glu Asp Ala Asp Ser Ser Val Lys Glu Asp Trp Lys Tyr Val
485 490 495
Ala Met Val Ile Asp Arg Ile Phe Leu Trp Leu Phe Ile Ile Val Cys
500 505 510
Phe Leu Gly Thr Ile Gly Leu Phe Leu Pro Pro Phe Leu Ala Gly Met
515 520 525
Ile
<210> 115
<211> 537
<212> PRT
<213> 智人（Homo sapiens）
<400> 115
Met Pro His Leu Met Glu Arg Met Val Gly Ser Gly Leu Leu Trp Leu
1 5 10 15
Ala Leu Val Ser Cys Ile Leu Thr Gln Ala Ser Ala Val Gln Arg Gly
20 25 30
Tyr Gly Asn Pro Ile Glu Ala Ser Ser Tyr Gly Leu Asp Leu Asp Cys
35 40 45
Gly Ala Pro Gly Thr Pro Glu Ala His Val Cys Phe Asp Pro Cys Gln
50 55 60
Asn Tyr Thr Leu Leu Asp Glu Pro Phe Arg Ser Thr Glu Asn Ser Ala
65 70 75 80
Gly Ser Gln Gly Cys Asp Lys Asn Met Ser Gly Trp Tyr Arg Phe Val
85 90 95
Gly Glu Gly Gly Val Arg Met Ser Glu Thr Cys Val Gln Val His Arg
100 105 110
Cys Gln Thr Asp Ala Pro Met Trp Leu Asn Gly Thr His Pro Ala Leu
115 120 125
Gly Asp Gly Ile Thr Asn His Thr Ala Cys Ala His Trp Ser Gly Asn
130 135 140
Cys Cys Phe Trp Lys Thr Glu Val Leu Val Lys Ala Cys Pro Gly Gly
145 150 155 160
Tyr His Val Tyr Arg Leu Glu Gly Thr Pro Trp Cys Asn Leu Arg Tyr
165 170 175
Cys Thr Val Pro Arg Asp Pro Ser Thr Val Glu Asp Lys Cys Glu Lys
180 185 190
Ala Cys Arg Pro Glu Glu Glu Cys Leu Ala Leu Asn Ser Thr Trp Gly
195 200 205
Cys Phe Cys Arg Gln Asp Leu Asn Ser Ser Asp Val His Ser Leu Gln
210 215 220
Pro Gln Leu Asp Cys Gly Pro Arg Glu Ile Lys Val Lys Val Asp Lys
225 230 235 240
Cys Leu Leu Gly Gly Leu Gly Leu Gly Glu Glu Val Ile Ala Tyr Leu
245 250 255
Arg Asp Pro Asn Cys Ser Ser Ile Leu Gln Thr Glu Glu Arg Asn Trp
260 265 270
Val Ser Val Thr Ser Pro Val Gln Ala Ser Ala Cys Arg Asn Ile Leu
275 280 285
Glu Arg Asn Gln Thr His Ala Ile Tyr Lys Asn Thr Leu Ser Leu Val
290 295 300
Asn Asp Phe Ile Ile Arg Asp Thr Ile Leu Asn Ile Asn Phe Gln Cys
305 310 315 320
Ala Tyr Pro Leu Asp Met Lys Val Ser Leu Gln Ala Ala Leu Gln Pro
325 330 335
Ile Val Ser Ser Leu Asn Val Ser Val Asp Gly Asn Gly Glu Phe Ile
340 345 350
Val Arg Met Ala Leu Phe Gln Asp Gln Asn Tyr Thr Asn Pro Tyr Glu
355 360 365
Gly Asp Ala Val Glu Leu Ser Val Glu Ser Val Leu Tyr Val Gly Ala
370 375 380
Ile Leu Glu Gln Gly Asp Thr Ser Arg Phe Asn Leu Val Leu Arg Asn
385 390 395 400
Cys Tyr Ala Thr Pro Thr Glu Asp Lys Ala Asp Leu Val Lys Tyr Phe
405 410 415
Ile Ile Arg Asn Ser Cys Ser Asn Gln Arg Asp Ser Thr Ile His Val
420 425 430
Glu Glu Asn Gly Gln Ser Ser Glu Ser Arg Phe Ser Val Gln Met Phe
435 440 445
Met Phe Ala Gly His Tyr Asp Leu Val Phe Leu His Cys Glu Ile His
450 455 460
Leu Cys Asp Ser Leu Asn Glu Gln Cys Gln Pro Ser Cys Ser Arg Ser
465 470 475 480
Gln Val Arg Ser Glu Val Pro Ala Ile Asp Leu Ala Arg Val Leu Asp
485 490 495
Leu Gly Pro Ile Thr Arg Arg Gly Ala Gln Ser Pro Gly Val Met Asn
500 505 510
Gly Thr Pro Ser Thr Ala Gly Phe Leu Val Ala Trp Pro Met Val Leu
515 520 525
Leu Thr Val Leu Leu Ala Trp Leu Phe
530 535
<210> 116
<211> 426
<212> PRT
<213> 智人（Homo sapiens）
<400> 116
Met Gly Pro Leu Pro Ala Pro Ser Cys Thr Gln Arg Ile Thr Trp Lys
1 5 10 15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr
20 25 30
Thr Ala Glu Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly
35 40 45
Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Pro Gly
50 55 60
Tyr Phe Trp Tyr Lys Gly Glu Met Thr Asp Leu Tyr His Tyr Ile Ile
65 70 75 80
Ser Tyr Ile Val Asp Gly Lys Ile Ile Ile Tyr Gly Pro Ala Tyr Ser
85 90 95
Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val
100 105 110
Thr Arg Lys Asp Ala Gly Thr Tyr Thr Leu His Ile Ile Lys Arg Gly
115 120 125
Asp Glu Thr Arg Glu Glu Ile Arg His Phe Thr Phe Thr Leu Tyr Leu
130 135 140
Glu Thr Pro Lys Pro Tyr Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu
145 150 155 160
Ala Met Glu Ala Val Arg Leu Ile Cys Asp Pro Glu Thr Leu Asp Ala
165 170 175
Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Val Thr His Arg
180 185 190
Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Tyr Leu Phe Gly Val Thr
195 200 205
Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser
210 215 220
Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro
225 230 235 240
Ile Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp
245 250 255
Val Leu Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile
260 265 270
Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Gly Val Lys Arg
275 280 285
Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu
290 295 300
Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Leu Arg
305 310 315 320
Ser Asn Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Arg
325 330 335
Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Asp Leu
340 345 350
Ser Cys Phe Thr Glu Ser Asn Pro Pro Ala Glu Tyr Phe Trp Thr Ile
355 360 365
Asn Gly Lys Phe Gln Gln Ser Gly Gln Lys Leu Phe Ile Pro Gln Ile
370 375 380
Thr Arg Asn His Ser Gly Leu Tyr Ala Cys Ser Val His Asn Ser Ala
385 390 395 400
Thr Gly Lys Glu Ile Ser Lys Ser Met Thr Val Lys Val Ser Gly Pro
405 410 415
Cys His Gly Asp Leu Thr Glu Ser Gln Ser
420 425
<210> 117
<211> 328
<212> PRT
<213> 智人（Homo sapiens）
<400> 117
Met Glu Lys Ser Ile Trp Leu Leu Ala Cys Leu Ala Trp Val Leu Pro
1 5 10 15
Thr Gly Ser Phe Val Arg Thr Lys Ile Asp Thr Thr Glu Asn Leu Leu
20 25 30
Asn Thr Glu Val His Ser Ser Pro Ala Gln Arg Trp Ser Met Gln Val
35 40 45
Pro Pro Glu Val Ser Ala Glu Ala Gly Asp Ala Ala Val Leu Pro Cys
50 55 60
Thr Phe Thr His Pro His Arg His Tyr Asp Gly Pro Leu Thr Ala Ile
65 70 75 80
Trp Arg Ala Gly Glu Pro Tyr Ala Gly Pro Gln Val Phe Arg Cys Ala
85 90 95
Ala Ala Arg Gly Ser Glu Leu Cys Gln Thr Ala Leu Ser Leu His Gly
100 105 110
Arg Phe Arg Leu Leu Gly Asn Pro Arg Arg Asn Asp Leu Ser Leu Arg
115 120 125
Val Glu Arg Leu Ala Leu Ala Asp Asp Arg Arg Tyr Phe Cys Arg Val
130 135 140
Glu Phe Ala Gly Asp Val His Asp Arg Tyr Glu Ser Arg His Gly Val
145 150 155 160
Arg Leu His Val Thr Ala Ala Pro Arg Ile Val Asn Ile Ser Val Leu
165 170 175
Pro Ser Pro Ala His Ala Phe Arg Ala Leu Cys Thr Ala Glu Gly Glu
180 185 190
Pro Pro Pro Ala Leu Ala Trp Ser Gly Pro Ala Leu Gly Asn Ser Leu
195 200 205
Ala Ala Val Arg Ser Pro Arg Glu Gly His Gly His Leu Val Thr Ala
210 215 220
Glu Leu Pro Ala Leu Thr His Asp Gly Arg Tyr Thr Cys Thr Ala Ala
225 230 235 240
Asn Ser Leu Gly Arg Ser Glu Ala Ser Val Tyr Leu Phe Arg Phe His
245 250 255
Gly Ala Ser Gly Ala Ser Thr Val Ala Leu Leu Leu Gly Ala Leu Gly
260 265 270
Phe Lys Ala Leu Leu Leu Leu Gly Val Leu Ala Ala Arg Ala Ala Arg
275 280 285
Arg Arg Pro Glu His Leu Asp Thr Pro Asp Thr Pro Pro Arg Ser Gln
290 295 300
Ala Gln Glu Ser Asn Tyr Glu Asn Leu Ser Gln Met Asn Pro Arg Ser
305 310 315 320
Pro Pro Ala Thr Met Cys Ser Pro
325
<210> 118
<211> 620
<212> PRT
<213> 智人（Homo sapiens）
<400> 118
Met Ser Lys Ser Lys Cys Ser Val Gly Leu Met Ser Ser Val Val Ala
1 5 10 15
Pro Ala Lys Glu Pro Asn Ala Val Gly Pro Lys Glu Val Glu Leu Ile
20 25 30
Leu Val Lys Glu Gln Asn Gly Val Gln Leu Thr Ser Ser Thr Leu Thr
35 40 45
Asn Pro Arg Gln Ser Pro Val Glu Ala Gln Asp Arg Glu Thr Trp Gly
50 55 60
Lys Lys Ile Asp Phe Leu Leu Ser Val Ile Gly Phe Ala Val Asp Leu
65 70 75 80
Ala Asn Val Trp Arg Phe Pro Tyr Leu Cys Tyr Lys Asn Gly Gly Gly
85 90 95
Ala Phe Leu Val Pro Tyr Leu Leu Phe Met Val Ile Ala Gly Met Pro
100 105 110
Leu Phe Tyr Met Glu Leu Ala Leu Gly Gln Phe Asn Arg Glu Gly Ala
115 120 125
Ala Gly Val Trp Lys Ile Cys Pro Ile Leu Lys Gly Val Gly Phe Thr
130 135 140
Val Ile Leu Ile Ser Leu Tyr Val Gly Phe Phe Tyr Asn Val Ile Ile
145 150 155 160
Ala Trp Ala Leu His Tyr Leu Phe Ser Ser Phe Thr Thr Glu Leu Pro
165 170 175
Trp Ile His Cys Asn Asn Ser Trp Asn Ser Pro Asn Cys Ser Asp Ala
180 185 190
His Pro Gly Asp Ser Ser Gly Asp Ser Ser Gly Leu Asn Asp Thr Phe
195 200 205
Gly Thr Thr Pro Ala Ala Glu Tyr Phe Glu Arg Gly Val Leu His Leu
210 215 220
His Gln Ser His Gly Ile Asp Asp Leu Gly Pro Pro Arg Trp Gln Leu
225 230 235 240
Thr Ala Cys Leu Val Leu Val Ile Val Leu Leu Tyr Phe Ser Leu Trp
245 250 255
Lys Gly Val Lys Thr Ser Gly Lys Val Val Trp Ile Thr Ala Thr Met
260 265 270
Pro Tyr Val Val Leu Thr Ala Leu Leu Leu Arg Gly Val Thr Leu Pro
275 280 285
Gly Ala Ile Asp Gly Ile Arg Ala Tyr Leu Ser Val Asp Phe Tyr Arg
290 295 300
Leu Cys Glu Ala Ser Val Trp Ile Asp Ala Ala Thr Gln Val Cys Phe
305 310 315 320
Ser Leu Gly Val Gly Phe Gly Val Leu Ile Ala Phe Ser Ser Tyr Asn
325 330 335
Lys Phe Thr Asn Asn Cys Tyr Arg Asp Ala Ile Val Thr Thr Ser Ile
340 345 350
Asn Ser Leu Thr Ser Phe Ser Ser Gly Phe Val Val Phe Ser Phe Leu
355 360 365
Gly Tyr Met Ala Gln Lys His Ser Val Pro Ile Gly Asp Val Ala Lys
370 375 380
Asp Gly Pro Gly Leu Ile Phe Ile Ile Tyr Pro Glu Ala Ile Ala Thr
385 390 395 400
Leu Pro Leu Ser Ser Ala Trp Ala Val Val Phe Phe Ile Met Leu Leu
405 410 415
Thr Leu Gly Ile Asp Ser Ala Met Gly Gly Met Glu Ser Val Ile Thr
420 425 430
Gly Leu Ile Asp Glu Phe Gln Leu Leu His Arg His Arg Glu Leu Phe
435 440 445
Thr Leu Phe Ile Val Leu Ala Thr Phe Leu Leu Ser Leu Phe Cys Val
450 455 460
Thr Asn Gly Gly Ile Tyr Val Phe Thr Leu Leu Asp His Phe Ala Ala
465 470 475 480
Gly Thr Ser Ile Leu Phe Gly Val Leu Ile Glu Ala Ile Gly Val Ala
485 490 495
Trp Phe Tyr Gly Val Gly Gln Phe Ser Asp Asp Ile Gln Gln Met Thr
500 505 510
Gly Gln Arg Pro Ser Leu Tyr Trp Arg Leu Cys Trp Lys Leu Val Ser
515 520 525
Pro Cys Phe Leu Leu Phe Val Val Val Val Ser Ile Val Thr Phe Arg
530 535 540
Pro Pro His Tyr Gly Ala Tyr Ile Phe Pro Asp Trp Ala Asn Ala Leu
545 550 555 560
Gly Trp Val Ile Ala Thr Ser Ser Met Ala Met Val Pro Ile Tyr Ala
565 570 575
Ala Tyr Lys Phe Cys Ser Leu Pro Gly Ser Phe Arg Glu Lys Leu Ala
580 585 590
Tyr Ala Ile Ala Pro Glu Lys Asp Arg Glu Leu Val Asp Arg Gly Glu
595 600 605
Val Arg Gln Phe Thr Leu Arg His Trp Leu Lys Val
610 615 620
<210> 119
<211> 398
<212> PRT
<213> 智人（Homo sapiens）
<400> 119
Met His Thr Val Ala Thr Ser Gly Pro Asn Ala Ser Trp Gly Ala Pro
1 5 10 15
Ala Asn Ala Ser Gly Cys Pro Gly Cys Gly Ala Asn Ala Ser Asp Gly
20 25 30
Pro Val Pro Ser Pro Arg Ala Val Asp Ala Trp Leu Val Pro Leu Phe
35 40 45
Phe Ala Ala Leu Met Leu Leu Gly Leu Val Gly Asn Ser Leu Val Ile
50 55 60
Tyr Val Ile Cys Arg His Lys Pro Met Arg Thr Val Thr Asn Phe Tyr
65 70 75 80
Ile Ala Asn Leu Ala Ala Thr Asp Val Thr Phe Leu Leu Cys Cys Val
85 90 95
Pro Phe Thr Ala Leu Leu Tyr Pro Leu Pro Gly Trp Val Leu Gly Asp
100 105 110
Phe Met Cys Lys Phe Val Asn Tyr Ile Gln Gln Val Ser Val Gln Ala
115 120 125
Thr Cys Ala Thr Leu Thr Ala Met Ser Val Asp Arg Trp Tyr Val Thr
130 135 140
Val Phe Pro Leu Arg Ala Leu His Arg Arg Thr Pro Arg Leu Ala Leu
145 150 155 160
Ala Val Ser Leu Ser Ile Trp Val Gly Ser Ala Ala Val Ser Ala Pro
165 170 175
Val Leu Ala Leu His Arg Leu Ser Pro Gly Pro Arg Ala Tyr Cys Ser
180 185 190
Glu Ala Phe Pro Ser Arg Ala Leu Glu Arg Ala Phe Ala Leu Tyr Asn
195 200 205
Leu Leu Ala Leu Tyr Leu Leu Pro Leu Leu Ala Thr Cys Ala Cys Tyr
210 215 220
Ala Ala Met Leu Arg His Leu Gly Arg Val Ala Val Arg Pro Ala Pro
225 230 235 240
Ala Asp Ser Ala Leu Gln Gly Gln Val Leu Ala Glu Arg Ala Gly Ala
245 250 255
Val Arg Ala Lys Val Ser Arg Leu Val Ala Ala Val Val Leu Leu Phe
260 265 270
Ala Ala Cys Trp Gly Pro Ile Gln Leu Phe Leu Val Leu Gln Ala Leu
275 280 285
Gly Pro Ala Gly Ser Trp His Pro Arg Ser Tyr Ala Ala Tyr Ala Leu
290 295 300
Lys Thr Trp Ala His Cys Met Ser Tyr Ser Asn Ser Ala Leu Asn Pro
305 310 315 320
Leu Leu Tyr Ala Phe Leu Gly Ser His Phe Arg Gln Ala Phe Arg Arg
325 330 335
Val Cys Pro Cys Ala Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Gly
340 345 350
Pro Ser Asp Pro Ala Ala Pro His Ala Glu Leu Leu Arg Leu Gly Ser
355 360 365
His Pro Ala Pro Ala Arg Ala Gln Lys Pro Gly Ser Ser Gly Leu Ala
370 375 380
Ala Arg Gly Leu Cys Val Leu Gly Glu Asp Asn Ala Pro Leu
385 390 395
<210> 120
<211> 431
<212> PRT
<213> 智人（Homo sapiens）
<400> 120
Met Gln Ala Leu Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg
1 5 10 15
Asp His Asn Leu Thr Arg Glu Gln Phe Ile Ala Leu Tyr Arg Leu Arg
20 25 30
Pro Leu Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu Ala Leu
35 40 45
Val Leu Thr Gly Val Leu Ile Phe Ala Leu Ala Leu Phe Gly Asn Ala
50 55 60
Leu Val Phe Tyr Val Val Thr Arg Ser Lys Ala Met Arg Thr Val Thr
65 70 75 80
Asn Ile Phe Ile Cys Ser Leu Ala Leu Ser Asp Leu Leu Ile Thr Phe
85 90 95
Phe Cys Ile Pro Val Thr Met Leu Gln Asn Ile Ser Asp Asn Trp Leu
100 105 110
Gly Gly Ala Phe Ile Cys Lys Met Val Pro Phe Val Gln Ser Thr Ala
115 120 125
Val Val Thr Glu Ile Leu Thr Met Thr Cys Ile Ala Val Glu Arg His
130 135 140
Gln Gly Leu Val His Pro Phe Lys Met Lys Trp Gln Tyr Thr Asn Arg
145 150 155 160
Arg Ala Phe Thr Met Leu Gly Val Val Trp Leu Val Ala Val Ile Val
165 170 175
Gly Ser Pro Met Trp His Val Gln Gln Leu Glu Ile Lys Tyr Asp Phe
180 185 190
Leu Tyr Glu Lys Glu His Ile Cys Cys Leu Glu Glu Trp Thr Ser Pro
195 200 205
Val His Gln Lys Ile Tyr Thr Thr Phe Ile Leu Val Ile Leu Phe Leu
210 215 220
Leu Pro Leu Met Val Met Leu Ile Leu Tyr Ser Lys Ile Gly Tyr Glu
225 230 235 240
Leu Trp Ile Lys Lys Arg Val Gly Asp Gly Ser Val Leu Arg Thr Ile
245 250 255
His Gly Lys Glu Met Ser Lys Ile Ala Arg Lys Lys Lys Arg Ala Val
260 265 270
Ile Met Met Val Thr Val Val Ala Leu Phe Ala Val Cys Trp Ala Pro
275 280 285
Phe His Val Val His Met Met Ile Glu Tyr Ser Asn Phe Glu Lys Glu
290 295 300
Tyr Asp Asp Val Thr Ile Lys Met Ile Phe Ala Ile Val Gln Ile Ile
305 310 315 320
Gly Phe Ser Asn Ser Ile Cys Asn Pro Ile Val Tyr Ala Phe Met Asn
325 330 335
Glu Asn Phe Lys Lys Asn Val Leu Ser Ala Val Cys Tyr Cys Ile Val
340 345 350
Asn Lys Thr Phe Ser Pro Ala Gln Arg His Gly Asn Ser Gly Ile Thr
355 360 365
Met Met Arg Lys Lys Ala Lys Phe Ser Leu Arg Glu Asn Pro Val Glu
370 375 380
Glu Thr Lys Gly Glu Ala Phe Ser Asp Gly Asn Ile Glu Val Lys Leu
385 390 395 400
Cys Glu Gln Thr Glu Glu Lys Lys Lys Leu Lys Arg His Leu Ala Leu
405 410 415
Phe Arg Ser Glu Leu Ala Glu Asn Ser Pro Leu Asp Ser Gly His
420 425 430
<210> 121
<211> 335
<212> PRT
<213> 智人（Homo sapiens）
<400> 121
Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser
1 5 10 15
Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu
20 25 30
Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala
35 40 45
Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp
50 55 60
Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu
65 70 75 80
Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val
85 90 95
Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg
100 105 110
Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly
115 120 125
Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro
130 135 140
Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val
145 150 155 160
Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro
165 170 175
Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala
180 185 190
Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met
195 200 205
Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu
210 215 220
Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro
225 230 235 240
Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu
245 250 255
Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser
260 265 270
Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu
275 280 285
Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe
290 295 300
Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu
305 310 315 320
Ser Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly
325 330 335
<210> 122
<211> 220
<212> PRT
<213> 智人（Homo sapiens）
<400> 122
Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu
1 5 10 15
Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val
20 25 30
Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu
35 40 45
Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys
50 55 60
Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala
65 70 75 80
Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu
85 90 95
Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp
100 105 110
Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser
115 120 125
Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile
130 135 140
Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu
145 150 155 160
Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu
165 170 175
Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly
180 185 190
Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser
195 200 205
Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val
210 215 220
<210> 123
<211> 21
<212> PRT
<213> 智人（Homo sapiens）
<400> 123
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro
20
<210> 124
<211> 15
<212> PRT
<213> 智人（Homo sapiens）
<400> 124
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10 15
<210> 125
<211> 45
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 125
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
<210> 126
<211> 23
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 126
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
1 5 10 15
Leu Val Ile Thr Leu Tyr Cys
20
<210> 127
<211> 42
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 127
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
1 5 10 15
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
20 25 30
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
35 40
<210> 128
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 128
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly
1 5 10 15
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
20 25 30
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
35 40 45
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
50 55 60
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65 70 75 80
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
85 90 95
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
100 105 110
<210> 129
<211> 485
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 129
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met
20 25 30
Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser
35 40 45
Val Val Ile Ser Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser
50 55 60
Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val
65 70 75 80
Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr
85 90 95
Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln
100 105 110
Tyr His Arg Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
115 120 125
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
130 135 140
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Gly
145 150 155 160
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
165 170 175
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
180 185 190
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe
195 200 205
Lys Asp Lys Ala Thr Leu Thr Met Asp Lys Ser Ser Ser Thr Ala Tyr
210 215 220
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
225 230 235 240
Ala Arg Asp Tyr Arg Tyr Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr
245 250 255
Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr
260 265 270
Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala
275 280 285
Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe
290 295 300
Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val
305 310 315 320
Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys
325 330 335
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
340 345 350
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
355 360 365
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
370 375 380
Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
385 390 395 400
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro
405 410 415
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr
420 425 430
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly
435 440 445
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
450 455 460
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln
465 470 475 480
Ala Leu Pro Pro Arg
485
<210> 130
<211> 241
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 130
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Val Val Ile Ser Thr
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly
100 105 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln
115 120 125
Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Gly Ser Met Lys Ile Ser
130 135 140
Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val
145 150 155 160
Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro
165 170 175
Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr
180 185 190
Leu Thr Met Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser
195 200 205
Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys Ala Arg Asp Tyr Arg
210 215 220
Tyr Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
225 230 235 240
Ala
<210> 131
<211> 108
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 131
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly
1 5 10 15
Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Val Val Ile Ser Thr
20 25 30
Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser
50 55 60
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65 70 75 80
Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro
85 90 95
Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 132
<211> 118
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 132
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile
35 40 45
Gly Leu Ile Asn Pro Tyr Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe
50 55 60
Lys Asp Lys Ala Thr Leu Thr Met Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys
85 90 95
Ala Arg Asp Tyr Arg Tyr Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ala
115
<210> 133
<211> 488
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 133
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met
20 25 30
Ser Ala Thr Leu Gly Glu Lys Val Thr Met Ser Cys Arg Ala Thr Ser
35 40 45
Asn Val Lys Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro
50 55 60
Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala
65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
85 90 95
Ser Val Glu Ala Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr
100 105 110
Ser Ser Pro Ser Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly
115 120 125
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
130 135 140
Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
145 150 155 160
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met
165 170 175
Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg
180 185 190
Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys Gly
195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His Met Glu
210 215 220
Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg
225 230 235 240
Val Leu Phe Leu Asp Phe Asp Asp Pro Tyr Leu Met Asp Tyr Trp Gly
245 250 255
Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
260 265 270
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
275 280 285
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
290 295 300
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
305 310 315 320
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
325 330 335
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
340 345 350
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
355 360 365
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
370 375 380
Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
385 390 395 400
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
405 410 415
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
420 425 430
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
435 440 445
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
450 455 460
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
465 470 475 480
His Met Gln Ala Leu Pro Pro Arg
485
<210> 134
<211> 244
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 134
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Thr Leu Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Arg Ala Thr Ser Asn Val Lys Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr
35 40 45
Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Ala
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly
100 105 110
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser
115 120 125
Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
130 135 140
Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
145 150 155 160
Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn
165 170 175
Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr
180 185 190
Val Asp Lys Ser Ser Asn Thr Ala His Met Glu Leu Arg Ser Leu Thr
195 200 205
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Val Leu Phe Leu Asp
210 215 220
Phe Asp Asp Pro Tyr Leu Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
225 230 235 240
Thr Val Ser Ser
<210> 135
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 135
Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Thr Leu Gly Glu
1 5 10 15
Lys Val Thr Met Ser Cys Arg Ala Thr Ser Asn Val Lys Tyr Met Tyr
20 25 30
Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr Tyr
35 40 45
Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly
50 55 60
Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Ala Asp
65 70 75 80
Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Thr Phe
85 90 95
Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu
100 105
<210> 136
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 136
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala His
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Leu Phe Leu Asp Phe Asp Asp Pro Tyr Leu Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 137
<211> 485
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 137
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu
20 25 30
Ser Ala Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu
35 40 45
Asn Ile Asp Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser
50 55 60
Pro Gln Leu Leu Val Tyr Ala Ser Thr Leu Leu Val Asp Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Gln Phe Ser Leu Lys Ile
85 90 95
Asn Ser Leu Gln Ser Glu Asp Val Ala Arg Tyr Tyr Cys Gln His Tyr
100 105 110
Tyr Ser Ile Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser
145 150 155 160
Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Thr
165 170 175
Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Trp Val Val
180 185 190
Thr Ile Ser Ser Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys
195 200 205
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu
210 215 220
Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ile
225 230 235 240
Arg Gly Asp Tyr Arg Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr
245 250 255
Leu Val Thr Val Ser Thr Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr
260 265 270
Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala
275 280 285
Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe
290 295 300
Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val
305 310 315 320
Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys
325 330 335
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
340 345 350
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
355 360 365
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
370 375 380
Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
385 390 395 400
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro
405 410 415
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr
420 425 430
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly
435 440 445
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
450 455 460
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln
465 470 475 480
Ala Leu Pro Pro Arg
485
<210> 138
<211> 241
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 138
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Ala Ser Thr Leu Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Arg Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Ser
65 70 75 80
Glu Asp Val Ala Arg Tyr Tyr Cys Gln His Tyr Tyr Ser Ile Pro Tyr
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu
115 120 125
Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys
130 135 140
Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr Thr Met Ser Trp Val Arg
145 150 155 160
Gln Thr Pro Ala Lys Arg Leu Glu Trp Val Val Thr Ile Ser Ser Gly
165 170 175
Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile
180 185 190
Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu
195 200 205
Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ile Arg Gly Asp Tyr Arg
210 215 220
Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
225 230 235 240
Thr
<210> 139
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 139
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asp Ser Tyr
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val
35 40 45
Tyr Ala Ser Thr Leu Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Arg Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Ser
65 70 75 80
Glu Asp Val Ala Arg Tyr Tyr Cys Gln His Tyr Tyr Ser Ile Pro Tyr
85 90 95
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
100 105
<210> 140
<211> 119
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 140
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
1 5 10 15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr
20 25 30
Thr Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Trp Val
35 40 45
Val Thr Ile Ser Ser Gly Gly Gly Arg Thr Tyr Tyr Pro Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys
85 90 95
Ile Arg Gly Asp Tyr Arg Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Thr
115
<210> 141
<211> 488
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 141
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met
20 25 30
Ser Ala Thr Leu Gly Glu Lys Val Thr Met Ser Cys Arg Ala Thr Ser
35 40 45
Asn Val Lys Tyr Met Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro
50 55 60
Lys Leu Trp Ile Tyr Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala
65 70 75 80
Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser
85 90 95
Ser Val Glu Ala Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr
100 105 110
Ser Ser Pro Ser Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly
115 120 125
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val
130 135 140
Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val
145 150 155 160
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met
165 170 175
Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg
180 185 190
Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys Gly
195 200 205
Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His Met Glu
210 215 220
Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg
225 230 235 240
Val Leu Phe Leu Asp Phe Asp Asp Pro Tyr Leu Met Asp Tyr Trp Gly
245 250 255
Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
260 265 270
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
275 280 285
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
290 295 300
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
305 310 315 320
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
325 330 335
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
340 345 350
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
355 360 365
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
370 375 380
Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
385 390 395 400
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
405 410 415
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
420 425 430
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
435 440 445
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
450 455 460
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
465 470 475 480
His Met Gln Ala Leu Pro Pro Arg
485
<210> 142
<211> 244
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 142
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Thr Leu Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Arg Ala Thr Ser Asn Val Lys Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr
35 40 45
Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Ala
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly
100 105 110
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser
115 120 125
Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys
130 135 140
Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Phe Met Asn Trp Val Lys Gln
145 150 155 160
Ser His Gly Lys Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn
165 170 175
Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr
180 185 190
Val Asp Lys Ser Ser Ser Thr Ala His Met Glu Leu Arg Ser Leu Thr
195 200 205
Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Val Leu Phe Leu Asp
210 215 220
Phe Asp Asp Pro Tyr Leu Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
225 230 235 240
Thr Val Ser Ser
<210> 143
<211> 106
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 143
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Thr Leu Gly
1 5 10 15
Glu Lys Val Thr Met Ser Cys Arg Ala Thr Ser Asn Val Lys Tyr Met
20 25 30
Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp Ile Tyr
35 40 45
Tyr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser
50 55 60
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Ala
65 70 75 80
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Ser Ser Pro Ser Thr
85 90 95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
100 105
<210> 144
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 144
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
1 5 10 15
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
20 25 30
Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
35 40 45
Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65 70 75 80
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Val Leu Phe Leu Asp Phe Asp Asp Pro Tyr Leu Met Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
115 120
<210> 145
<211> 482
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 145
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser
20 25 30
Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Arg Gly Asp Ser Leu
35 40 45
Arg Lys Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Arg Gln Ala Pro
50 55 60
Gln Leu Val Ile Tyr His Lys Asn Asn Arg Ala Ser Gly Ile Pro Asp
65 70 75 80
Arg Phe Ser Gly Ser Ile Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr
85 90 95
Gly Ala Gln Ala Glu Asp Glu Ala Ala Tyr Phe Cys Asn Ser Arg Asp
100 105 110
Thr Ser Gly Asn Tyr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val
115 120 125
Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
130 135 140
Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
145 150 155 160
Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Asn
165 170 175
Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
180 185 190
Gly Glu Val His His Ser Gly Val Thr Thr Tyr Lys Pro Ser Leu Lys
195 200 205
Ser Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Leu Ser Leu
210 215 220
Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
225 230 235 240
Arg Glu Phe Ala Asp Asp Ala Phe Asp Ile Trp Gly Arg Gly Thr Met
245 250 255
Val Thr Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
260 265 270
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
275 280 285
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
290 295 300
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
305 310 315 320
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
325 330 335
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
340 345 350
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
355 360 365
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys
370 375 380
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
385 390 395 400
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
405 410 415
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
420 425 430
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
435 440 445
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
450 455 460
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
465 470 475 480
Pro Arg
<210> 146
<211> 238
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 146
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Arg Gly Asp Ser Leu Arg Lys Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Arg Gln Ala Pro Gln Leu Val Ile Tyr
35 40 45
His Lys Asn Asn Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ile Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Ala Tyr Phe Cys Asn Ser Arg Asp Thr Ser Gly Asn Tyr
85 90 95
Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly
100 105 110
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Gln Leu
115 120 125
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu
130 135 140
Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Asn Trp Trp Ser Trp Val
145 150 155 160
Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Val His His
165 170 175
Ser Gly Val Thr Thr Tyr Lys Pro Ser Leu Lys Ser Arg Val Thr Ile
180 185 190
Ser Val Asp Asn Ser Lys Asn Gln Leu Ser Leu Lys Leu Thr Ser Val
195 200 205
Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ala Asp
210 215 220
Asp Ala Phe Asp Ile Trp Gly Arg Gly Thr Met Val Thr Val
225 230 235
<210> 147
<211> 109
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 147
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
1 5 10 15
Thr Val Arg Ile Thr Cys Arg Gly Asp Ser Leu Arg Lys Tyr Tyr Ala
20 25 30
Ser Trp Tyr Gln Gln Lys Pro Arg Gln Ala Pro Gln Leu Val Ile Tyr
35 40 45
His Lys Asn Asn Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser
50 55 60
Ile Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65 70 75 80
Asp Glu Ala Ala Tyr Phe Cys Asn Ser Arg Asp Thr Ser Gly Asn Tyr
85 90 95
Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly
100 105
<210> 148
<211> 114
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 148
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
1 5 10 15
Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Ser Asn Trp
20 25 30
Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly
35 40 45
Glu Val His His Ser Gly Val Thr Thr Tyr Lys Pro Ser Leu Lys Ser
50 55 60
Arg Val Thr Ile Ser Val Asp Asn Ser Lys Asn Gln Leu Ser Leu Lys
65 70 75 80
Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg
85 90 95
Glu Phe Ala Asp Asp Ala Phe Asp Ile Trp Gly Arg Gly Thr Met Val
100 105 110
Thr Val
<210> 149
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 149
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 150
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 150
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Arg Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 151
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 151
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 152
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 152
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Lys Gln Ala Pro Gly His Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 153
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 153
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 154
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 154
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Arg Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 155
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 155
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 156
<211> 250
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 156
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
115 120 125
Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser
130 135 140
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asp
145 150 155 160
Met His Trp Val Lys Gln Ala Pro Gly His Gly Leu Glu Trp Ile Gly
165 170 175
Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
180 185 190
Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr Met
195 200 205
Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr
210 215 220
Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr Trp
225 230 235 240
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
245 250
<210> 157
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 157
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 158
<211> 112
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 158
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
1 5 10 15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His
85 90 95
Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
100 105 110
<210> 159
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 159
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
35 40 45
Gly Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 160
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 160
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Arg Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 161
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 161
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
35 40 45
Gly Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 162
<211> 123
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 162
Glu Ile Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
1 5 10 15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30
Asp Met His Trp Val Lys Gln Ala Pro Gly His Gly Leu Glu Trp Ile
35 40 45
Gly Thr Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
50 55 60
Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr
65 70 75 80
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Ser Phe Tyr Tyr Thr Tyr Ser Asn Tyr Asp Val Gly Phe Ala Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 163
<211> 482
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 163
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp
35 40 45
Leu Ile His Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala
50 55 60
Pro Lys Leu Leu Ile Tyr Gly Ala Thr Ser Leu Glu Thr Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
85 90 95
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr
100 105 110
Trp Thr Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
145 150 155 160
Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp Tyr
165 170 175
Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
180 185 190
Gly Tyr Ile Ser Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys
195 200 205
Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr Leu
210 215 220
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
225 230 235 240
Arg Trp Thr Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
245 250 255
Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
260 265 270
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
275 280 285
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
290 295 300
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
305 310 315 320
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
325 330 335
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
340 345 350
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
355 360 365
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys
370 375 380
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
385 390 395 400
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
405 410 415
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
420 425 430
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
435 440 445
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
450 455 460
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
465 470 475 480
Pro Arg
<210> 164
<211> 238
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 164
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
115 120 125
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
130 135 140
Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp Tyr Ala Trp Asn Trp Val
145 150 155 160
Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Tyr Ile Ser Tyr
165 170 175
Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Phe Thr Ile
180 185 190
Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu
195 200 205
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Thr Ser Gly
210 215 220
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
225 230 235
<210> 165
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 165
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
100 105
<210> 166
<211> 116
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 166
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp
20 25 30
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
35 40 45
Val Gly Tyr Ile Ser Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Trp Thr Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 167
<211> 482
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 167
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Ser Ser Phe Leu
20 25 30
Ser Val Ser Leu Gly Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp
35 40 45
Leu Ile His Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala
50 55 60
Pro Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Asn Asp Tyr Thr Leu Ser Ile
85 90 95
Ala Ser Leu Gln Thr Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr
100 105 110
Trp Thr Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
130 135 140
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gln Ser
145 150 155 160
Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Asn Asp Tyr
165 170 175
Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met
180 185 190
Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys
195 200 205
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu
210 215 220
His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala
225 230 235 240
Arg Trp Asp Gly Gly Leu Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr
245 250 255
Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
260 265 270
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
275 280 285
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
290 295 300
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
305 310 315 320
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
325 330 335
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
340 345 350
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
355 360 365
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys
370 375 380
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
385 390 395 400
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
405 410 415
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
420 425 430
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
435 440 445
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
450 455 460
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
465 470 475 480
Pro Arg
<210> 168
<211> 238
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 168
Asp Ile Gln Met Thr Gln Ser Ser Ser Phe Leu Ser Val Ser Leu Gly
1 5 10 15
Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Asn Asp Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr
65 70 75 80
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser
100 105 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu
115 120 125
Ser Gly Pro Gly Leu Val Asn Pro Ser Gln Ser Leu Ser Leu Thr Cys
130 135 140
Thr Val Thr Gly Tyr Ser Ile Thr Asn Asp Tyr Ala Trp Asn Trp Ile
145 150 155 160
Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Asn Tyr
165 170 175
Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile
180 185 190
Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu His Leu Asn Ser Val
195 200 205
Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Trp Asp Gly Gly
210 215 220
Leu Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala
225 230 235
<210> 169
<211> 107
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 169
Asp Ile Gln Met Thr Gln Ser Ser Ser Phe Leu Ser Val Ser Leu Gly
1 5 10 15
Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
35 40 45
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Asn Asp Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr
65 70 75 80
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
85 90 95
Thr Phe Gly Ser Gly Thr Lys Val Glu Ile Lys
100 105
<210> 170
<211> 116
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 170
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gln
1 5 10 15
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Asn Asp
20 25 30
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
35 40 45
Met Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
50 55 60
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65 70 75 80
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95
Ala Arg Trp Asp Gly Gly Leu Thr Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ala
115
<210> 171
<211> 298
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 171
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser
20 25 30
Gly Ser Pro Gln Gln Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile
35 40 45
Pro Ala Pro Gln Gly Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro
50 55 60
Asn Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe Thr Thr Thr Pro Ala
65 70 75 80
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
85 90 95
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
100 105 110
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
115 120 125
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
130 135 140
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
145 150 155 160
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
165 170 175
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
180 185 190
Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn
195 200 205
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
210 215 220
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
225 230 235 240
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
245 250 255
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
260 265 270
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
275 280 285
Ala Leu His Met Gln Ala Leu Pro Pro Arg
290 295
<210> 172
<211> 54
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 172
Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser Pro Gln Gln
1 5 10 15
Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala Pro Gln Gly
20 25 30
Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr Asn Trp Asn
35 40 45
Ser Phe Gly Leu Arg Phe
50
<210> 173
<211> 19
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 173
Gly Thr Thr Gly Cys Thr Cys Cys Ala Gly Gly Cys Cys Ala Cys Ala
1 5 10 15
Gly Cys Ala
<210> 174
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 174
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 175
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 175
Gln Trp Gly Thr Arg Tyr Arg
1 5
<210> 176
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 176
Glu Arg Gly Thr Leu Ala Arg
1 5
<210> 177
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 177
Arg Ser Asp Asn Leu Arg Glu
1 5
<210> 178
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 178
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 179
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 179
Thr Ser Gly Ala Leu Thr Arg
1 5
<210> 180
<211> 12
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 180
Gly Ala Cys Thr Thr Thr Gly Cys Ala Thr Gly Thr
1 5 10
<210> 181
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 181
Trp Arg Ser Ser Leu Ala Ser
1 5
<210> 182
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 182
Gln Ser Gly Ser Leu Thr Arg
1 5
<210> 183
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 183
His Lys Trp Val Leu Arg Gln
1 5
<210> 184
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 184
Asp Arg Ser Asn Leu Thr Arg
1 5
<210> 185
<211> 293
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 185
Met Gln Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Ile Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Thr Met Gly His Pro Arg Gly Lys Leu Ile Phe Gly Lys Gly
115 120 125
Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser
130 135 140
Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu
145 150 155 160
Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile
165 170 175
Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn
180 185 190
Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser
195 200 205
Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys
210 215 220
Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys
225 230 235 240
Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu
245 250 255
Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe
260 265 270
Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe
275 280 285
Leu Thr Arg Asp Cys
290
<210> 186
<211> 315
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 186
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu
1 5 10 15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr
20 25 30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile
35 40 45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu
50 55 60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys
65 70 75 80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu
85 90 95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile
100 105 110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Ala Gln Gln Glu Leu Gly Lys
115 120 125
Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys
130 135 140
Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser
145 150 155 160
Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu
165 170 175
Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys
180 185 190
Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn
195 200 205
Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu
210 215 220
Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly
225 230 235 240
Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr
245 250 255
Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu
260 265 270
Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu
275 280 285
Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg
290 295 300
Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
305 310 315
<210> 187
<211> 292
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 187
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Thr Leu Gly Met Gly Gly Glu Tyr Thr Asp Lys Leu Ile Phe
115 120 125
Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr
130 135 140
Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu
145 150 155 160
Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser
165 170 175
Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly
180 185 190
Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val
195 200 205
Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe
210 215 220
Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu
225 230 235 240
Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val
245 250 255
His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg
260 265 270
Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys
275 280 285
Leu Phe Phe Leu
290
<210> 188
<211> 313
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 188
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu
1 5 10 15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr
20 25 30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile
35 40 45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu
50 55 60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys
65 70 75 80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu
85 90 95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile
100 105 110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Trp Glu Leu Gly Lys Lys Ile
115 120 125
Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu
130 135 140
Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala
145 150 155 160
Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys
165 170 175
Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn
180 185 190
Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr
195 200 205
Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys
210 215 220
Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp
225 230 235 240
Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp
245 250 255
Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln
260 265 270
Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys
275 280 285
Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr
290 295 300
Ala Phe Cys Cys Asn Gly Glu Lys Ser
305 310
<210> 189
<211> 288
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 189
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Thr Leu Val Ser Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr
115 120 125
Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val
130 135 140
Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe
145 150 155 160
Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr
165 170 175
Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala
180 185 190
Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val
195 200 205
Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr
210 215 220
Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln
225 230 235 240
Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys
245 250 255
Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala
260 265 270
Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu
275 280 285
<210> 190
<211> 314
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 190
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu
1 5 10 15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr
20 25 30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile
35 40 45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu
50 55 60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys
65 70 75 80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu
85 90 95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile
100 105 110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Val Gly Glu Leu Gly Lys Lys
115 120 125
Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln
130 135 140
Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile
145 150 155 160
Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu
165 170 175
Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser
180 185 190
Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp
195 200 205
Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp
210 215 220
Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val
225 230 235 240
Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met
245 250 255
Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu
260 265 270
Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu
275 280 285
Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg
290 295 300
Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
305 310
<210> 191
<211> 291
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 191
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Thr Val Ala His Gly Gly Gly Thr Asp Lys Leu Ile Phe Gly
115 120 125
Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys
130 135 140
Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val
145 150 155 160
Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys
165 170 175
Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys
180 185 190
Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr
195 200 205
Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu
210 215 220
Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn
225 230 235 240
Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His
245 250 255
Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met
260 265 270
Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu
275 280 285
Phe Phe Leu
290
<210> 192
<211> 313
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 192
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu
1 5 10 15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr
20 25 30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile
35 40 45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu
50 55 60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys
65 70 75 80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu
85 90 95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile
100 105 110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Trp Glu Leu Gly Lys Lys Ile
115 120 125
Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu
130 135 140
Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala
145 150 155 160
Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys
165 170 175
Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn
180 185 190
Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr
195 200 205
Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys
210 215 220
Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp
225 230 235 240
Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp
245 250 255
Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln
260 265 270
Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys
275 280 285
Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr
290 295 300
Ala Phe Cys Cys Asn Gly Glu Lys Ser
305 310
<210> 193
<211> 291
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 193
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Asn Leu Ser Thr Gly Gly Tyr Thr Asp Lys Leu Ile Phe Gly
115 120 125
Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys
130 135 140
Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val
145 150 155 160
Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys
165 170 175
Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys
180 185 190
Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr
195 200 205
Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu
210 215 220
Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn
225 230 235 240
Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His
245 250 255
Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met
260 265 270
Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu
275 280 285
Phe Phe Leu
290
<210> 194
<211> 316
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 194
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala Leu
1 5 10 15
Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser Ser Thr
20 25 30
Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val Ser Gly Ile
35 40 45
Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu Arg Pro Gly Glu
50 55 60
Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp Gly Thr Val Arg Lys
65 70 75 80
Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu Val Asp Arg Ile Pro Glu
85 90 95
Thr Ser Thr Ser Thr Leu Thr Ile His Asn Val Glu Lys Gln Asp Ile
100 105 110
Ala Thr Tyr Tyr Cys Ala Leu Trp Glu Val Tyr Gln Gly Glu Leu Gly
115 120 125
Lys Lys Ile Lys Val Phe Gly Pro Gly Thr Lys Leu Ile Ile Thr Asp
130 135 140
Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro
145 150 155 160
Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu
165 170 175
Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys
180 185 190
Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr
195 200 205
Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser
210 215 220
Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn
225 230 235 240
Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile
245 250 255
Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu
260 265 270
Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu
275 280 285
Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu
290 295 300
Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
305 310 315
<210> 195
<211> 291
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 195
Met Glu Arg Ile Ser Ser Leu Ile His Leu Ser Leu Phe Trp Ala Gly
1 5 10 15
Val Met Ser Ala Ile Glu Leu Val Pro Glu His Gln Thr Val Pro Val
20 25 30
Ser Ile Gly Val Pro Ala Thr Leu Arg Cys Ser Met Lys Gly Glu Ala
35 40 45
Ile Gly Asn Tyr Tyr Ile Asn Trp Tyr Arg Lys Thr Gln Gly Asn Thr
50 55 60
Met Thr Phe Ile Tyr Arg Glu Lys Asp Ile Tyr Gly Pro Gly Phe Lys
65 70 75 80
Asp Asn Phe Gln Gly Asp Ile Asp Ile Ala Lys Asn Leu Ala Val Leu
85 90 95
Lys Ile Leu Ala Pro Ser Glu Arg Asp Glu Gly Ser Tyr Tyr Cys Ala
100 105 110
Cys Asp Ile Leu Gly Glu Lys Pro Tyr Thr Asp Lys Leu Ile Phe Gly
115 120 125
Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys
130 135 140
Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val
145 150 155 160
Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys
165 170 175
Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys
180 185 190
Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr
195 200 205
Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu
210 215 220
Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn
225 230 235 240
Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His
245 250 255
Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met
260 265 270
Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu
275 280 285
Phe Phe Leu
290
<210> 196
<211> 339
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 196
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc 60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc 120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat 180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc 240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc 300
tacgacgccc ttcacatgca ggccctgccc cctcgctaa 339
<210> 197
<211> 276
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 197
Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe
1 5 10 15
Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu
20 25 30
Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val
35 40 45
Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly
50 55 60
Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn
65 70 75 80
Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu
85 90 95
His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val
100 105 110
Val Ser Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly
115 120 125
Thr Gln Leu Thr Val Trp Pro Asp Ile Gln Asn Pro Asp Pro Ala Val
130 135 140
Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe
145 150 155 160
Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp
165 170 175
Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe
180 185 190
Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys
195 200 205
Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro
210 215 220
Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu
225 230 235 240
Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
245 250 255
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
260 265 270
Leu Trp Ser Ser
275
<210> 198
<211> 313
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 198
Met Thr Ile Arg Leu Leu Cys Tyr Val Gly Phe Tyr Phe Leu Gly Ala
1 5 10 15
Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile
20 25 30
Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His
35 40 45
Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu
50 55 60
Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser
65 70 75 80
Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr
85 90 95
Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser
100 105 110
Ser Gly Leu Arg Asp Arg Gly Leu Tyr Glu Gln Tyr Phe Gly Pro Gly
115 120 125
Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
130 135 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145 150 155 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
165 170 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr
180 185 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
195 200 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
210 215 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225 230 235 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
245 250 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
260 265 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
275 280 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
290 295 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305 310
<210> 199
<211> 267
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 199
Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr
1 5 10 15
Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly
20 25 30
Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly
35 40 45
Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser
50 55 60
Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe
65 70 75 80
Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln
85 90 95
Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Lys Asp Ser Asn Tyr
100 105 110
Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asn Ile
115 120 125
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
130 135 140
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
145 150 155 160
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu
165 170 175
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
180 185 190
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
195 200 205
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys
210 215 220
Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn
225 230 235 240
Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe
245 250 255
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
260 265
<210> 200
<211> 138
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 200
Met Ala Val Leu Val Leu Leu Leu Cys Leu Leu Ile Phe Pro Ser Cys
1 5 10 15
Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln
20 25 30
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ser Ser Leu
35 40 45
Thr Ser Asn Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu
50 55 60
Glu Trp Met Gly Val Ile Trp Ser Asn Gly Asp Ala Asp Tyr Asn Ser
65 70 75 80
Ala Ile Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln
85 90 95
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr
100 105 110
Phe Cys Ala Ser Pro Tyr Tyr Gly Tyr Tyr Phe Pro Phe Asp Tyr Trp
115 120 125
Gly Gln Gly Val Met Val Thr Val Ser Ser
130 135
<210> 201
<211> 3533
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 201
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagatgaca cagactacat 2160
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccagatgg aactgttaaa ctcctgatct 2280
accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt gggtctggaa 2340
cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact tacttttgcc 2400
aacagggtaa tacgcttccg tacacgttcg gaggggggac caagctggag atcacaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgaaa ctgcaggagt 2520
caggacctgg cctggtggcg ccctcacaga gcctgtccgt cacatgcact gtctcagggg 2580
tctcattacc cgactatggt gtaagctgga ttcgccagcc tccacgaaag ggtctggagt 2640
ggctgggagt aatatggggt agtgaaacca catactataa ttcagctctc aaatccagac 2700
tgaccatcat caaggacaac tccaagagcc aagttttctt aaaaatgaac agtctgcaaa 2760
ctgatgacac agccatttac tactgtgcca aacattatta ctacggtggt agctatgcta 2820
tggactactg gggccaagga acctcagtca ccgtctcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc 3060
tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac 3120
cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag 3180
gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg 3240
gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg 3300
acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg 3360
aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga 3420
tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag 3480
ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa 3533
<210> 202
<211> 488
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 202
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
35 40 45
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
50 55 60
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
65 70 75 80
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
85 90 95
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
100 105 110
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
115 120 125
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
130 135 140
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
145 150 155 160
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
165 170 175
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
180 185 190
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
195 200 205
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
210 215 220
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
225 230 235 240
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
245 250 255
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
260 265 270
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
275 280 285
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
290 295 300
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
305 310 315 320
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
325 330 335
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
340 345 350
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
355 360 365
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
370 375 380
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
385 390 395 400
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
405 410 415
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
420 425 430
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
435 440 445
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
450 455 460
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
465 470 475 480
His Met Gln Ala Leu Pro Pro Arg
485
<210> 203
<211> 486
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 203
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
20 25 30
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
35 40 45
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
50 55 60
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
85 90 95
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
100 105 110
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145 150 155 160
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
165 170 175
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
180 185 190
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
195 200 205
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
210 215 220
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225 230 235 240
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
245 250 255
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
260 265 270
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
275 280 285
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
290 295 300
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305 310 315 320
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
325 330 335
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
340 345 350
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
355 360 365
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
370 375 380
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385 390 395 400
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
405 410 415
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
420 425 430
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
435 440 445
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
450 455 460
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465 470 475 480
Gln Ala Leu Pro Pro Arg
485
<210> 204
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 204
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagatgac acagactaca tcctccctgt 2160
ctgcctctct gggagacaga gtcaccatca gttgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccagatg gaactgttaa actcctgatc taccatacat 2280
caagattaca ctcaggagtc ccatcaaggt tcagtggcag tgggtctgga acagattatt 2340
ctctcaccat tagcaacctg gagcaagaag atattgccac ttacttttgc caacagggta 2400
atacgcttcc gtacacgttc ggagggggga ccaagctgga gatcacaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgaa actgcaggag tcaggacctg 2520
gcctggtggc gccctcacag agcctgtccg tcacatgcac tgtctcaggg gtctcattac 2580
ccgactatgg tgtaagctgg attcgccagc ctccacgaaa gggtctggag tggctgggag 2640
taatatgggg tagtgaaacc acatactata attcagctct caaatccaga ctgaccatca 2700
tcaaggacaa ctccaagagc caagttttct taaaaatgaa cagtctgcaa actgatgaca 2760
cagccattta ctactgtgcc aaacattatt actacggtgg tagctatgct atggactact 2820
ggggccaagg aacctcagtc accgtctcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 205
<211> 485
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 205
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
35 40 45
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
50 55 60
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
65 70 75 80
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
85 90 95
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
100 105 110
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
115 120 125
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
130 135 140
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
145 150 155 160
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
165 170 175
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
180 185 190
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
195 200 205
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
210 215 220
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
225 230 235 240
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
245 250 255
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
260 265 270
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
275 280 285
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
290 295 300
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
305 310 315 320
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly Arg Lys
325 330 335
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
340 345 350
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
355 360 365
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
370 375 380
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
385 390 395 400
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro
405 410 415
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr
420 425 430
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly
435 440 445
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
450 455 460
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln
465 470 475 480
Ala Leu Pro Pro Arg
485
<210> 206
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 206
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagatgaca cagactacat 2160
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccagatgg aactgttaaa ctcctgatct 2280
accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt gggtctggaa 2340
cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact tacttttgcc 2400
aacagggtaa tacgcttccg tacacgttcg gaggggggac caagctggag atcacaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgaaa ctgcaggagt 2520
caggacctgg cctggtggcg ccctcacaga gcctgtccgt cacatgcact gtctcagggg 2580
tctcattacc cgactatggt gtaagctgga ttcgccagcc tccacgaaag ggtctggagt 2640
ggctgggagt aatatggggt agtgaaacca catactataa ttcagctctc aaatccagac 2700
tgaccatcat caaggacaac tccaagagcc aagttttctt aaaaatgaac agtctgcaaa 2760
ctgatgacac agccatttac tactgtgcca aacattatta ctacggtggt agctatgcta 2820
tggactactg gggccaagga acctcagtca ccgtctcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcacca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 207
<211> 483
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 207
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
20 25 30
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
35 40 45
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
50 55 60
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
85 90 95
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
100 105 110
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser
145 150 155 160
Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly
165 170 175
Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly
180 185 190
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
195 200 205
Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys
210 215 220
Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys
225 230 235 240
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
245 250 255
Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
260 265 270
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
275 280 285
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
290 295 300
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305 310 315 320
Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly Arg Lys Lys Leu
325 330 335
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln
340 345 350
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly
355 360 365
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr
370 375 380
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg
385 390 395 400
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met
405 410 415
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
420 425 430
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys
435 440 445
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu
450 455 460
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu
465 470 475 480
Pro Pro Arg
<210> 208
<211> 3515
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 208
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagatgac acagactaca tcctccctgt 2160
ctgcctctct gggagacaga gtcaccatca gttgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccagatg gaactgttaa actcctgatc taccatacat 2280
caagattaca ctcaggagtc ccatcaaggt tcagtggcag tgggtctgga acagattatt 2340
ctctcaccat tagcaacctg gagcaagaag atattgccac ttacttttgc caacagggta 2400
atacgcttcc gtacacgttc ggagggggga ccaagctgga gatcacaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgaa actgcaggag tcaggacctg 2520
gcctggtggc gccctcacag agcctgtccg tcacatgcac tgtctcaggg gtctcattac 2580
ccgactatgg tgtaagctgg attcgccagc ctccacgaaa gggtctggag tggctgggag 2640
taatatgggg tagtgaaacc acatactata attcagctct caaatccaga ctgaccatca 2700
tcaaggacaa ctccaagagc caagttttct taaaaatgaa cagtctgcaa actgatgaca 2760
cagccattta ctactgtgcc aaacattatt actacggtgg tagctatgct atggactact 2820
ggggccaagg aacctcagtc accgtctcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc aaacggggca 3060
gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag 3120
aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgagag 3180
tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac cagctctata 3240
acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagagg cgtggccggg 3300
accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac 3360
tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga 3420
ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg 3480
acgcccttca catgcaggcc ctgccccctc gctaa 3515
<210> 209
<211> 3533
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 209
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagatgaca cagactacat 2160
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccagatgg aactgttaaa ctcctgatct 2280
accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt gggtctggaa 2340
cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact tacttttgcc 2400
aacagggtaa tacgcttccg tacacgttcg gaggggggac caagctggag atcacaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgaaa ctgcaggagt 2520
caggacctgg cctggtggcg ccctcacaga gcctgtccgt cacatgcact gtctcagggg 2580
tctcattacc cgactatggt gtaagctgga ttcgccagcc tccacgaaag ggtctggagt 2640
ggctgggagt aatatggggt agtgaaacca catactataa ttcagctctc aaatccagac 2700
tgaccatcat caaggacaac tccaagagcc aagttttctt aaaaatgaac agtctgcaaa 2760
ctgatgacac agccatttac tactgtgcca aacattatta ctacggtggt agctatgcta 2820
tggactactg gggccaagga acctcagtca ccgtctcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc 3060
tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac 3120
cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag 3180
gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg 3240
gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg 3300
acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg 3360
aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga 3420
tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag 3480
ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa 3533
<210> 210
<211> 490
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 210
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn
20 25 30
Pro Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys
35 40 45
Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln
50 55 60
Lys Pro Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu
65 70 75 80
Ala Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp
85 90 95
Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
100 105 110
Tyr Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr
115 120 125
Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
130 135 140
Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly
145 150 155 160
Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly
165 170 175
Phe Thr Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu
180 185 190
Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr
195 200 205
Thr Thr His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
210 215 220
Asp Asp Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val
225 230 235 240
Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr
245 250 255
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
325 330 335
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
340 345 350
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
355 360 365
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
370 375 380
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn
385 390 395 400
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
405 410 415
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
420 425 430
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
435 440 445
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
450 455 460
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
465 470 475 480
Ala Leu His Met Gln Ala Leu Pro Pro Arg
485 490
<210> 211
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 211
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagatgac acagactaca tcctccctgt 2160
ctgcctctct gggagacaga gtcaccatca gttgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccagatg gaactgttaa actcctgatc taccatacat 2280
caagattaca ctcaggagtc ccatcaaggt tcagtggcag tgggtctgga acagattatt 2340
ctctcaccat tagcaacctg gagcaagaag atattgccac ttacttttgc caacagggta 2400
atacgcttcc gtacacgttc ggagggggga ccaagctgga gatcacaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgaa actgcaggag tcaggacctg 2520
gcctggtggc gccctcacag agcctgtccg tcacatgcac tgtctcaggg gtctcattac 2580
ccgactatgg tgtaagctgg attcgccagc ctccacgaaa gggtctggag tggctgggag 2640
taatatgggg tagtgaaacc acatactata attcagctct caaatccaga ctgaccatca 2700
tcaaggacaa ctccaagagc caagttttct taaaaatgaa cagtctgcaa actgatgaca 2760
cagccattta ctactgtgcc aaacattatt actacggtgg tagctatgct atggactact 2820
ggggccaagg aacctcagtc accgtctcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 212
<211> 487
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 212
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn
20 25 30
Pro Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys
35 40 45
Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln
50 55 60
Lys Pro Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu
65 70 75 80
Ala Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp
85 90 95
Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
100 105 110
Tyr Cys Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr
115 120 125
Lys Leu Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
130 135 140
Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly
145 150 155 160
Leu Val Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly
165 170 175
Phe Thr Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu
180 185 190
Lys Gly Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr
195 200 205
Thr Thr His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
210 215 220
Asp Asp Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val
225 230 235 240
Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr
245 250 255
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly
325 330 335
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
340 345 350
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
355 360 365
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
370 375 380
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385 390 395 400
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
405 410 415
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
420 425 430
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
435 440 445
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
450 455 460
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465 470 475 480
Met Gln Ala Leu Pro Pro Arg
485
<210> 213
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 213
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagatgaca cagactacat 2160
cctccctgtc tgcctctctg ggagacagag tcaccatcag ttgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccagatgg aactgttaaa ctcctgatct 2280
accatacatc aagattacac tcaggagtcc catcaaggtt cagtggcagt gggtctggaa 2340
cagattattc tctcaccatt agcaacctgg agcaagaaga tattgccact tacttttgcc 2400
aacagggtaa tacgcttccg tacacgttcg gaggggggac caagctggag atcacaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgaaa ctgcaggagt 2520
caggacctgg cctggtggcg ccctcacaga gcctgtccgt cacatgcact gtctcagggg 2580
tctcattacc cgactatggt gtaagctgga ttcgccagcc tccacgaaag ggtctggagt 2640
ggctgggagt aatatggggt agtgaaacca catactataa ttcagctctc aaatccagac 2700
tgaccatcat caaggacaac tccaagagcc aagttttctt aaaaatgaac agtctgcaaa 2760
ctgatgacac agccatttac tactgtgcca aacattatta ctacggtggt agctatgcta 2820
tggactactg gggccaagga acctcagtca ccgtctcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcacca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 214
<211> 3515
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 214
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagatgac acagactaca tcctccctgt 2160
ctgcctctct gggagacaga gtcaccatca gttgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccagatg gaactgttaa actcctgatc taccatacat 2280
caagattaca ctcaggagtc ccatcaaggt tcagtggcag tgggtctgga acagattatt 2340
ctctcaccat tagcaacctg gagcaagaag atattgccac ttacttttgc caacagggta 2400
atacgcttcc gtacacgttc ggagggggga ccaagctgga gatcacaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgaa actgcaggag tcaggacctg 2520
gcctggtggc gccctcacag agcctgtccg tcacatgcac tgtctcaggg gtctcattac 2580
ccgactatgg tgtaagctgg attcgccagc ctccacgaaa gggtctggag tggctgggag 2640
taatatgggg tagtgaaacc acatactata attcagctct caaatccaga ctgaccatca 2700
tcaaggacaa ctccaagagc caagttttct taaaaatgaa cagtctgcaa actgatgaca 2760
cagccattta ctactgtgcc aaacattatt actacggtgg tagctatgct atggactact 2820
ggggccaagg aacctcagtc accgtctcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc aaacggggca 3060
gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag 3120
aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgagag 3180
tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac cagctctata 3240
acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagagg cgtggccggg 3300
accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac 3360
tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga 3420
ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg 3480
acgcccttca catgcaggcc ctgccccctc gctaa 3515
<210> 215
<211> 3533
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 215
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccga 2160
gcagcctgag cgcgagcgtg ggtgatcgcg tgaccattac ctgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccgggtaa agcgccgaaa ctgttaattt 2280
atcatacatc aagattacac tcaggcgtgc cgtcgcgttt tagcggctcg ggttcgggca 2340
ccgattttac cctgaccatc tcgagcttgc agccggagga cttcgccacc tactattgcc 2400
aacagggtaa tacgcttccg tacacgttcg gtcagggcac caaagtggag atcaaaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgcag ctggtggagt 2520
ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca gcctctggag 2580
tgtccctgcc tgattatggc gtgtcctggg tccgccaggc tccagggaag gggctggagt 2640
gggtttcagt gatctggggc agcgagacaa cctactacaa cagcgccctg aagtcccgat 2700
tcaccatctc cagagacaat gccaagaact cactgtatct gcaaatgaac agcctgagag 2760
ccgaggacac ggctgtgtat tactgtgcga agcactacta ctacggcggc agctacgcta 2820
tggactactg gggccaagga accctggtca ccgtgtcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcaccc 3060
tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca tttatgagac 3120
cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa gaagaagaag 3180
gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg tacaagcagg 3240
gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac gatgttttgg 3300
acaagaggcg tggccgggac cctgagatgg ggggaaagcc gagaaggaag aaccctcagg 3360
aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt gagattggga 3420
tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt ctcagtacag 3480
ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc taa 3533
<210> 216
<211> 486
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 216
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
35 40 45
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
50 55 60
Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
85 90 95
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
100 105 110
Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
145 150 155 160
Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr Gly
165 170 175
Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
180 185 190
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
195 200 205
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln
210 215 220
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
225 230 235 240
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
245 250 255
Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
260 265 270
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
275 280 285
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
290 295 300
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305 310 315 320
Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg
325 330 335
Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln
340 345 350
Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu
355 360 365
Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala
370 375 380
Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu
385 390 395 400
Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp
405 410 415
Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu
420 425 430
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile
435 440 445
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr
450 455 460
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met
465 470 475 480
Gln Ala Leu Pro Pro Arg
485
<210> 217
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 217
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagcccg agcagcctga 2160
gcgcgagcgt gggtgatcgc gtgaccatta cctgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccgggta aagcgccgaa actgttaatt tatcatacat 2280
caagattaca ctcaggcgtg ccgtcgcgtt ttagcggctc gggttcgggc accgatttta 2340
ccctgaccat ctcgagcttg cagccggagg acttcgccac ctactattgc caacagggta 2400
atacgcttcc gtacacgttc ggtcagggca ccaaagtgga gatcaaaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgca gctggtggag tctgggggag 2520
gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga gtgtccctgc 2580
ctgattatgg cgtgtcctgg gtccgccagg ctccagggaa ggggctggag tgggtttcag 2640
tgatctgggg cagcgagaca acctactaca acagcgccct gaagtcccga ttcaccatct 2700
ccagagacaa tgccaagaac tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca 2760
cggctgtgta ttactgtgcg aagcactact actacggcgg cagctacgct atggactact 2820
ggggccaagg aaccctggtc accgtgtcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 218
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 218
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccga 2160
gcagcctgag cgcgagcgtg ggtgatcgcg tgaccattac ctgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccgggtaa agcgccgaaa ctgttaattt 2280
atcatacatc aagattacac tcaggcgtgc cgtcgcgttt tagcggctcg ggttcgggca 2340
ccgattttac cctgaccatc tcgagcttgc agccggagga cttcgccacc tactattgcc 2400
aacagggtaa tacgcttccg tacacgttcg gtcagggcac caaagtggag atcaaaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgcag ctggtggagt 2520
ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca gcctctggag 2580
tgtccctgcc tgattatggc gtgtcctggg tccgccaggc tccagggaag gggctggagt 2640
gggtttcagt gatctggggc agcgagacaa cctactacaa cagcgccctg aagtcccgat 2700
tcaccatctc cagagacaat gccaagaact cactgtatct gcaaatgaac agcctgagag 2760
ccgaggacac ggctgtgtat tactgtgcga agcactacta ctacggcggc agctacgcta 2820
tggactactg gggccaagga accctggtca ccgtgtcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcacca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 219
<211> 483
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 219
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
35 40 45
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
50 55 60
Pro Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
85 90 95
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
100 105 110
Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu
130 135 140
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
145 150 155 160
Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr Gly
165 170 175
Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
180 185 190
Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser
195 200 205
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln
210 215 220
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys
225 230 235 240
His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly
245 250 255
Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro
260 265 270
Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu
275 280 285
Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp
290 295 300
Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly
305 310 315 320
Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly Arg Lys Lys Leu
325 330 335
Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln
340 345 350
Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly
355 360 365
Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr
370 375 380
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg
385 390 395 400
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met
405 410 415
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
420 425 430
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys
435 440 445
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu
450 455 460
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu
465 470 475 480
Pro Pro Arg
<210> 220
<211> 3515
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 220
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagcccg agcagcctga 2160
gcgcgagcgt gggtgatcgc gtgaccatta cctgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccgggta aagcgccgaa actgttaatt tatcatacat 2280
caagattaca ctcaggcgtg ccgtcgcgtt ttagcggctc gggttcgggc accgatttta 2340
ccctgaccat ctcgagcttg cagccggagg acttcgccac ctactattgc caacagggta 2400
atacgcttcc gtacacgttc ggtcagggca ccaaagtgga gatcaaaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgca gctggtggag tctgggggag 2520
gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga gtgtccctgc 2580
ctgattatgg cgtgtcctgg gtccgccagg ctccagggaa ggggctggag tgggtttcag 2640
tgatctgggg cagcgagaca acctactaca acagcgccct gaagtcccga ttcaccatct 2700
ccagagacaa tgccaagaac tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca 2760
cggctgtgta ttactgtgcg aagcactact actacggcgg cagctacgct atggactact 2820
ggggccaagg aaccctggtc accgtgtcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc aaacggggca 3060
gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag 3120
aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgagag 3180
tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac cagctctata 3240
acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagagg cgtggccggg 3300
accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac 3360
tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga 3420
ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg 3480
acgcccttca catgcaggcc ctgccccctc gctaa 3515
<210> 221
<211> 3533
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 221
Ala Thr Gly Gly Cys Cys Thr Thr Ala Cys Cys Ala Gly Thr Gly Ala
1 5 10 15
Cys Cys Gly Cys Cys Thr Thr Gly Cys Thr Cys Cys Thr Gly Cys Cys
20 25 30
Gly Cys Thr Gly Gly Cys Cys Thr Thr Gly Cys Thr Gly Cys Thr Cys
35 40 45
Cys Ala Cys Gly Cys Cys Gly Cys Cys Ala Gly Gly Cys Cys Gly Gly
50 55 60
Ala Cys Ala Thr Cys Gly Thr Gly Ala Thr Gly Ala Cys Cys Cys Ala
65 70 75 80
Gly Thr Cys Cys Cys Cys Cys Thr Cys Cys Ala Gly Cys Cys Thr Gly
85 90 95
Ala Cys Ala Gly Thr Gly Ala Cys Ala Gly Cys Cys Gly Gly Cys Gly
100 105 110
Ala Gly Ala Ala Gly Gly Thr Gly Ala Cys Ala Ala Thr Gly Ala Thr
115 120 125
Cys Thr Gly Thr Ala Ala Gly Thr Cys Cys Ala Gly Cys Cys Ala Gly
130 135 140
Ala Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Gly Cys Gly
145 150 155 160
Gly Cys Gly Ala Cys Cys Ala Gly Ala Ala Gly Ala Ala Cys Thr Ala
165 170 175
Cys Cys Thr Gly Ala Cys Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly
180 185 190
Cys Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Cys Ala Gly Cys
195 200 205
Cys Cys Cys Cys Cys Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr
210 215 220
Cys Thr Thr Cys Thr Gly Gly Gly Cys Cys Ala Gly Cys Ala Cys Ala
225 230 235 240
Ala Gly Gly Gly Ala Gly Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys
245 250 255
Cys Cys Gly Ala Cys Ala Gly Ala Thr Thr Cys Ala Cys Ala Gly Gly
260 265 270
Cys Ala Gly Cys Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys Cys
275 280 285
Gly Ala Cys Thr Thr Cys Ala Cys Ala Cys Thr Gly Ala Cys Cys Ala
290 295 300
Thr Thr Thr Cys Cys Thr Cys Cys Gly Thr Gly Cys Ala Gly Gly Cys
305 310 315 320
Cys Gly Ala Gly Gly Ala Cys Cys Thr Cys Gly Cys Cys Gly Thr Gly
325 330 335
Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Ala Ala Cys Gly
340 345 350
Ala Cys Thr Ala Cys Thr Cys Cys Thr Ala Cys Cys Cys Cys Cys Thr
355 360 365
Gly Ala Cys Ala Thr Thr Cys Gly Gly Cys Gly Cys Cys Gly Gly Cys
370 375 380
Ala Cys Cys Ala Ala Ala Cys Thr Gly Gly Ala Gly Cys Thr Gly Ala
385 390 395 400
Ala Gly Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Thr Cys
405 410 415
Gly Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Gly Thr Cys Gly
420 425 430
Gly Gly Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Thr Cys Thr Cys
435 440 445
Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Cys Cys Ala Gly Cys Ala
450 455 460
Gly Thr Cys Cys Gly Ala Thr Gly Cys Cys Gly Ala Gly Cys Thr Gly
465 470 475 480
Gly Thr Gly Ala Ala Gly Cys Cys Cys Gly Gly Ala Ala Gly Cys Ala
485 490 495
Gly Cys Gly Thr Cys Ala Ala Gly Ala Thr Cys Ala Gly Cys Thr Gly
500 505 510
Thr Ala Ala Gly Gly Cys Cys Thr Cys Cys Gly Gly Cys Thr Ala Cys
515 520 525
Ala Cys Cys Thr Thr Cys Ala Cys Ala Gly Ala Cys Cys Ala Cys Gly
530 535 540
Cys Cys Ala Thr Cys Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala Ala
545 550 555 560
Gly Cys Ala Gly Ala Ala Gly Cys Cys Cys Gly Ala Gly Cys Ala Gly
565 570 575
Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Cys Gly
580 585 590
Gly Cys Cys Ala Cys Thr Thr Thr Ala Gly Cys Cys Cys Cys Gly Gly
595 600 605
Ala Ala Ala Cys Ala Cys Cys Gly Ala Cys Ala Thr Cys Ala Ala Gly
610 615 620
Thr Ala Cys Ala Ala Cys Gly Ala Cys Ala Ala Gly Thr Thr Cys Ala
625 630 635 640
Ala Gly Gly Gly Cys Ala Ala Gly Gly Cys Cys Ala Cys Cys Cys Thr
645 650 655
Gly Ala Cys Cys Gly Thr Gly Gly Ala Cys Ala Gly Gly Ala Gly Cys
660 665 670
Ala Gly Cys Ala Gly Cys Ala Cys Cys Gly Cys Cys Thr Ala Cys Ala
675 680 685
Thr Gly Cys Ala Gly Cys Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr
690 695 700
Gly Ala Cys Ala Ala Gly Cys Gly Ala Gly Gly Ala Cys Ala Gly Cys
705 710 715 720
Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Thr Cys Thr Gly Cys Ala
725 730 735
Ala Gly Ala Cys Cys Thr Cys Cys Ala Cys Cys Thr Thr Cys Thr Thr
740 745 750
Cys Thr Thr Cys Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys
755 760 765
Cys Ala Gly Gly Gly Ala Ala Cys Cys Ala Cys Cys Cys Thr Gly Ala
770 775 780
Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Ala Cys Cys Ala Cys
785 790 795 800
Gly Ala Cys Gly Cys Cys Ala Gly Cys Gly Cys Cys Gly Cys Gly Ala
805 810 815
Cys Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys Gly Gly Cys Gly Cys
820 825 830
Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Gly Thr Cys Gly Cys Ala
835 840 845
Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Gly Cys Gly Cys
850 855 860
Cys Cys Ala Gly Ala Gly Gly Cys Gly Thr Gly Cys Cys Gly Gly Cys
865 870 875 880
Cys Ala Gly Cys Gly Gly Cys Gly Gly Gly Gly Gly Gly Cys Gly Cys
885 890 895
Ala Gly Thr Gly Cys Ala Cys Ala Cys Gly Ala Gly Gly Gly Gly Gly
900 905 910
Cys Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys Cys Thr Gly Thr Gly
915 920 925
Ala Thr Ala Thr Cys Thr Ala Cys Ala Thr Cys Thr Gly Gly Gly Cys
930 935 940
Gly Cys Cys Cys Thr Thr Gly Gly Cys Cys Gly Gly Gly Ala Cys Thr
945 950 955 960
Thr Gly Thr Gly Gly Gly Gly Thr Cys Cys Thr Thr Cys Thr Cys Cys
965 970 975
Thr Gly Thr Cys Ala Cys Thr Gly Gly Thr Thr Ala Thr Cys Ala Cys
980 985 990
Cys Cys Thr Thr Thr Ala Cys Thr Gly Cys Ala Ala Ala Cys Gly Gly
995 1000 1005
Gly Gly Cys Ala Gly Ala Ala Ala Gly Ala Ala Ala Cys Thr Cys Cys
1010 1015 1020
Thr Gly Thr Ala Thr Ala Thr Ala Thr Thr Cys Ala Ala Ala Cys Ala
1025 1030 1035 1040
Ala Cys Cys Ala Thr Thr Thr Ala Thr Gly Ala Gly Ala Cys Cys Ala
1045 1050 1055
Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Cys Thr Cys Ala Ala Gly
1060 1065 1070
Ala Gly Gly Ala Ala Gly Ala Thr Gly Gly Cys Thr Gly Thr Ala Gly
1075 1080 1085
Cys Thr Gly Cys Cys Gly Ala Thr Thr Thr Cys Cys Ala Gly Ala Ala
1090 1095 1100
Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Gly Ala Thr
1105 1110 1115 1120
Gly Thr Gly Ala Ala Cys Thr Gly Ala Gly Ala Gly Thr Gly Ala Ala
1125 1130 1135
Gly Thr Thr Cys Ala Gly Cys Ala Gly Gly Ala Gly Cys Gly Cys Ala
1140 1145 1150
Gly Ala Cys Gly Cys Cys Cys Cys Cys Gly Cys Gly Thr Ala Cys Ala
1155 1160 1165
Ala Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Ala Ala Cys Cys Ala
1170 1175 1180
Gly Cys Thr Cys Thr Ala Thr Ala Ala Cys Gly Ala Gly Cys Thr Cys
1185 1190 1195 1200
Ala Ala Thr Cys Thr Ala Gly Gly Ala Cys Gly Ala Ala Gly Ala Gly
1205 1210 1215
Ala Gly Gly Ala Gly Thr Ala Cys Gly Ala Thr Gly Thr Thr Thr Thr
1220 1225 1230
Gly Gly Ala Cys Ala Ala Gly Ala Gly Gly Cys Gly Thr Gly Gly Cys
1235 1240 1245
Cys Gly Gly Gly Ala Cys Cys Cys Thr Gly Ala Gly Ala Thr Gly Gly
1250 1255 1260
Gly Gly Gly Gly Ala Ala Ala Gly Cys Cys Gly Ala Gly Ala Ala Gly
1265 1270 1275 1280
Gly Ala Ala Gly Ala Ala Cys Cys Cys Thr Cys Ala Gly Gly Ala Ala
1285 1290 1295
Gly Gly Cys Cys Thr Gly Thr Ala Cys Ala Ala Thr Gly Ala Ala Cys
1300 1305 1310
Thr Gly Cys Ala Gly Ala Ala Ala Gly Ala Thr Ala Ala Gly Ala Thr
1315 1320 1325
Gly Gly Cys Gly Gly Ala Gly Gly Cys Cys Thr Ala Cys Ala Gly Thr
1330 1335 1340
Gly Ala Gly Ala Thr Thr Gly Gly Gly Ala Thr Gly Ala Ala Ala Gly
1345 1350 1355 1360
Gly Cys Gly Ala Gly Cys Gly Cys Cys Gly Gly Ala Gly Gly Gly Gly
1365 1370 1375
Cys Ala Ala Gly Gly Gly Gly Cys Ala Cys Gly Ala Thr Gly Gly Cys
1380 1385 1390
Cys Thr Thr Thr Ala Cys Cys Ala Gly Gly Gly Thr Cys Thr Cys Ala
1395 1400 1405
Gly Thr Ala Cys Ala Gly Cys Cys Ala Cys Cys Ala Ala Gly Gly Ala
1410 1415 1420
Cys Ala Cys Cys Thr Ala Cys Gly Ala Cys Gly Cys Cys Cys Thr Thr
1425 1430 1435 1440
Cys Ala Cys Ala Thr Gly Cys Ala Gly Gly Cys Cys Cys Thr Gly Cys
1445 1450 1455
Cys Cys Cys Cys Thr Cys Gly Cys Thr Ala Ala Thr Cys Thr Ala Gly
1460 1465 1470
Ala Gly Gly Cys Gly Cys Gly Cys Cys Cys Cys Thr Cys Thr Cys Cys
1475 1480 1485
Cys Thr Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Thr Ala Ala Cys
1490 1495 1500
Gly Thr Thr Ala Cys Thr Gly Gly Cys Cys Gly Ala Ala Gly Cys Cys
1505 1510 1515 1520
Gly Cys Thr Thr Gly Gly Ala Ala Thr Ala Ala Gly Gly Cys Cys Gly
1525 1530 1535
Gly Thr Gly Thr Gly Cys Gly Thr Thr Thr Gly Thr Cys Thr Ala Thr
1540 1545 1550
Ala Thr Gly Thr Thr Ala Thr Thr Thr Thr Cys Cys Ala Cys Cys Ala
1555 1560 1565
Thr Ala Thr Thr Gly Cys Cys Gly Thr Cys Thr Thr Thr Thr Gly Gly
1570 1575 1580
Cys Ala Ala Thr Gly Thr Gly Ala Gly Gly Gly Cys Cys Cys Gly Gly
1585 1590 1595 1600
Ala Ala Ala Cys Cys Thr Gly Gly Cys Cys Cys Thr Gly Thr Cys Thr
1605 1610 1615
Thr Cys Thr Thr Gly Ala Cys Gly Ala Gly Cys Ala Thr Thr Cys Cys
1620 1625 1630
Thr Ala Gly Gly Gly Gly Thr Cys Thr Thr Thr Cys Cys Cys Cys Thr
1635 1640 1645
Cys Thr Cys Gly Cys Cys Ala Ala Ala Gly Gly Ala Ala Thr Gly Cys
1650 1655 1660
Ala Ala Gly Gly Thr Cys Thr Gly Thr Thr Gly Ala Ala Thr Gly Thr
1665 1670 1675 1680
Cys Gly Thr Gly Ala Ala Gly Gly Ala Ala Gly Cys Ala Gly Thr Thr
1685 1690 1695
Cys Cys Thr Cys Thr Gly Gly Ala Ala Gly Cys Thr Thr Cys Thr Thr
1700 1705 1710
Gly Ala Ala Gly Ala Cys Ala Ala Ala Cys Ala Ala Cys Gly Thr Cys
1715 1720 1725
Thr Gly Thr Ala Gly Cys Gly Ala Cys Cys Cys Thr Thr Thr Gly Cys
1730 1735 1740
Ala Gly Gly Cys Ala Gly Cys Gly Gly Ala Ala Cys Cys Cys Cys Cys
1745 1750 1755 1760
Cys Ala Cys Cys Thr Gly Gly Cys Gly Ala Cys Ala Gly Gly Thr Gly
1765 1770 1775
Cys Cys Thr Cys Thr Gly Cys Gly Gly Cys Cys Ala Ala Ala Ala Gly
1780 1785 1790
Cys Cys Ala Cys Gly Thr Gly Thr Ala Thr Ala Ala Gly Ala Thr Ala
1795 1800 1805
Cys Ala Cys Cys Thr Gly Cys Ala Ala Ala Gly Gly Cys Gly Gly Cys
1810 1815 1820
Ala Cys Ala Ala Cys Cys Cys Cys Ala Gly Thr Gly Cys Cys Ala Cys
1825 1830 1835 1840
Gly Thr Thr Gly Thr Gly Ala Gly Thr Thr Gly Gly Ala Thr Ala Gly
1845 1850 1855
Thr Thr Gly Thr Gly Gly Ala Ala Ala Gly Ala Gly Thr Cys Ala Ala
1860 1865 1870
Ala Thr Gly Gly Cys Thr Cys Thr Cys Cys Thr Cys Ala Ala Gly Cys
1875 1880 1885
Gly Thr Ala Thr Thr Cys Ala Ala Cys Ala Ala Gly Gly Gly Gly Cys
1890 1895 1900
Thr Gly Ala Ala Gly Gly Ala Thr Gly Cys Cys Cys Ala Gly Ala Ala
1905 1910 1915 1920
Gly Gly Thr Ala Cys Cys Cys Cys Ala Thr Thr Gly Thr Ala Thr Gly
1925 1930 1935
Gly Gly Ala Thr Cys Thr Gly Ala Thr Cys Thr Gly Gly Gly Gly Cys
1940 1945 1950
Cys Thr Cys Gly Gly Thr Ala Cys Ala Cys Ala Thr Gly Cys Thr Thr
1955 1960 1965
Thr Ala Cys Ala Thr Gly Thr Gly Thr Thr Thr Ala Gly Thr Cys Gly
1970 1975 1980
Ala Gly Gly Thr Thr Ala Ala Ala Ala Ala Ala Ala Cys Gly Thr Cys
1985 1990 1995 2000
Thr Ala Gly Gly Cys Cys Cys Cys Cys Cys Gly Ala Ala Cys Cys Ala
2005 2010 2015
Cys Gly Gly Gly Gly Ala Cys Gly Thr Gly Gly Thr Thr Thr Thr Cys
2020 2025 2030
Cys Thr Thr Thr Gly Ala Ala Ala Ala Ala Cys Ala Cys Gly Ala Thr
2035 2040 2045
Gly Ala Thr Ala Ala Thr Ala Thr Gly Gly Cys Cys Ala Cys Ala Ala
2050 2055 2060
Cys Cys Cys Ala Thr Ala Thr Gly Ala Thr Gly Gly Cys Cys Thr Thr
2065 2070 2075 2080
Ala Cys Cys Ala Gly Thr Gly Ala Cys Cys Gly Cys Cys Thr Thr Gly
2085 2090 2095
Cys Thr Cys Cys Thr Gly Cys Cys Gly Cys Thr Gly Gly Cys Cys Thr
2100 2105 2110
Thr Gly Cys Thr Gly Cys Thr Cys Cys Ala Cys Gly Cys Cys Gly Cys
2115 2120 2125
Cys Ala Gly Gly Cys Cys Gly Gly Ala Thr Ala Thr Cys Cys Ala Gly
2130 2135 2140
Ala Thr Gly Ala Cys Cys Cys Ala Gly Ala Gly Cys Cys Cys Gly Ala
2145 2150 2155 2160
Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Cys Gly Cys Gly Ala Gly
2165 2170 2175
Cys Gly Thr Gly Gly Gly Thr Gly Ala Thr Cys Gly Cys Gly Thr Gly
2180 2185 2190
Ala Cys Cys Ala Thr Thr Ala Cys Cys Thr Gly Cys Ala Gly Gly Gly
2195 2200 2205
Cys Ala Ala Gly Thr Cys Ala Gly Gly Ala Cys Ala Thr Thr Ala Gly
2210 2215 2220
Thr Ala Ala Ala Thr Ala Thr Thr Thr Ala Ala Ala Thr Thr Gly Gly
2225 2230 2235 2240
Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala Ala Cys Cys Gly Gly
2245 2250 2255
Gly Thr Ala Ala Ala Gly Cys Gly Cys Cys Gly Ala Ala Ala Cys Thr
2260 2265 2270
Gly Thr Thr Ala Ala Thr Thr Thr Ala Thr Cys Ala Thr Ala Cys Ala
2275 2280 2285
Thr Cys Ala Ala Gly Ala Thr Thr Ala Cys Ala Cys Thr Cys Ala Gly
2290 2295 2300
Gly Cys Gly Thr Gly Cys Cys Gly Thr Cys Gly Cys Gly Thr Thr Thr
2305 2310 2315 2320
Thr Ala Gly Cys Gly Gly Cys Thr Cys Gly Gly Gly Thr Thr Cys Gly
2325 2330 2335
Gly Gly Cys Ala Cys Cys Gly Ala Thr Thr Thr Thr Ala Cys Cys Cys
2340 2345 2350
Thr Gly Ala Cys Cys Ala Thr Cys Thr Cys Gly Ala Gly Cys Thr Thr
2355 2360 2365
Gly Cys Ala Gly Cys Cys Gly Gly Ala Gly Gly Ala Cys Thr Thr Cys
2370 2375 2380
Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Thr Thr Gly Cys Cys
2385 2390 2395 2400
Ala Ala Cys Ala Gly Gly Gly Thr Ala Ala Thr Ala Cys Gly Cys Thr
2405 2410 2415
Thr Cys Cys Gly Thr Ala Cys Ala Cys Gly Thr Thr Cys Gly Gly Thr
2420 2425 2430
Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Ala Ala Gly Thr Gly Gly
2435 2440 2445
Ala Gly Ala Thr Cys Ala Ala Ala Gly Gly Thr Gly Gly Cys Gly Gly
2450 2455 2460
Thr Gly Gly Cys Thr Cys Gly Gly Gly Cys Gly Gly Thr Gly Gly Thr
2465 2470 2475 2480
Gly Gly Gly Thr Cys Gly Gly Gly Thr Gly Gly Cys Gly Gly Cys Gly
2485 2490 2495
Gly Ala Thr Cys Thr Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr
2500 2505 2510
Gly Gly Thr Gly Gly Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala
2515 2520 2525
Gly Gly Cys Thr Thr Gly Gly Thr Ala Cys Ala Gly Cys Cys Thr Gly
2530 2535 2540
Gly Gly Gly Gly Gly Thr Cys Cys Cys Thr Gly Ala Gly Ala Cys Thr
2545 2550 2555 2560
Cys Thr Cys Cys Thr Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr
2565 2570 2575
Gly Gly Ala Gly Thr Gly Thr Cys Cys Cys Thr Gly Cys Cys Thr Gly
2580 2585 2590
Ala Thr Thr Ala Thr Gly Gly Cys Gly Thr Gly Thr Cys Cys Thr Gly
2595 2600 2605
Gly Gly Thr Cys Cys Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala
2610 2615 2620
Gly Gly Gly Ala Ala Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr
2625 2630 2635 2640
Gly Gly Gly Thr Thr Thr Cys Ala Gly Thr Gly Ala Thr Cys Thr Gly
2645 2650 2655
Gly Gly Gly Cys Ala Gly Cys Gly Ala Gly Ala Cys Ala Ala Cys Cys
2660 2665 2670
Thr Ala Cys Thr Ala Cys Ala Ala Cys Ala Gly Cys Gly Cys Cys Cys
2675 2680 2685
Thr Gly Ala Ala Gly Thr Cys Cys Cys Gly Ala Thr Thr Cys Ala Cys
2690 2695 2700
Cys Ala Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Thr
2705 2710 2715 2720
Gly Cys Cys Ala Ala Gly Ala Ala Cys Thr Cys Ala Cys Thr Gly Thr
2725 2730 2735
Ala Thr Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly
2740 2745 2750
Cys Cys Thr Gly Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Cys
2755 2760 2765
Ala Cys Gly Gly Cys Thr Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr
2770 2775 2780
Gly Thr Gly Cys Gly Ala Ala Gly Cys Ala Cys Thr Ala Cys Thr Ala
2785 2790 2795 2800
Cys Thr Ala Cys Gly Gly Cys Gly Gly Cys Ala Gly Cys Thr Ala Cys
2805 2810 2815
Gly Cys Thr Ala Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly
2820 2825 2830
Gly Cys Cys Ala Ala Gly Gly Ala Ala Cys Cys Cys Thr Gly Gly Thr
2835 2840 2845
Cys Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Cys Ala Ala Cys Cys
2850 2855 2860
Ala Cys Gly Ala Cys Gly Cys Cys Ala Gly Cys Gly Cys Cys Gly Cys
2865 2870 2875 2880
Gly Ala Cys Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys Gly Gly Cys
2885 2890 2895
Gly Cys Cys Cys Ala Cys Cys Ala Thr Cys Gly Cys Gly Thr Cys Gly
2900 2905 2910
Cys Ala Gly Cys Cys Cys Cys Thr Gly Thr Cys Cys Cys Thr Gly Cys
2915 2920 2925
Gly Cys Cys Cys Ala Gly Ala Gly Gly Cys Gly Thr Gly Cys Cys Gly
2930 2935 2940
Gly Cys Cys Ala Gly Cys Gly Gly Cys Gly Gly Gly Gly Gly Gly Cys
2945 2950 2955 2960
Gly Cys Ala Gly Thr Gly Cys Ala Cys Ala Cys Gly Ala Gly Gly Gly
2965 2970 2975
Gly Gly Cys Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys Cys Thr Gly
2980 2985 2990
Thr Gly Ala Thr Ala Thr Cys Thr Ala Cys Ala Thr Cys Thr Gly Gly
2995 3000 3005
Gly Cys Gly Cys Cys Cys Thr Thr Gly Gly Cys Cys Gly Gly Gly Ala
3010 3015 3020
Cys Thr Thr Gly Thr Gly Gly Gly Gly Thr Cys Cys Thr Thr Cys Thr
3025 3030 3035 3040
Cys Cys Thr Gly Thr Cys Ala Cys Thr Gly Gly Thr Thr Ala Thr Cys
3045 3050 3055
Ala Cys Cys Cys Thr Thr Thr Ala Cys Thr Gly Cys Ala Ala Ala Cys
3060 3065 3070
Gly Gly Gly Gly Cys Ala Gly Ala Ala Ala Gly Ala Ala Ala Cys Thr
3075 3080 3085
Cys Cys Thr Gly Thr Ala Thr Ala Thr Ala Thr Thr Cys Ala Ala Ala
3090 3095 3100
Cys Ala Ala Cys Cys Ala Thr Thr Thr Ala Thr Gly Ala Gly Ala Cys
3105 3110 3115 3120
Cys Ala Gly Thr Ala Cys Ala Ala Ala Cys Thr Ala Cys Thr Cys Ala
3125 3130 3135
Ala Gly Ala Gly Gly Ala Ala Gly Ala Thr Gly Gly Cys Thr Gly Thr
3140 3145 3150
Ala Gly Cys Thr Gly Cys Cys Gly Ala Thr Thr Thr Cys Cys Ala Gly
3155 3160 3165
Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Gly
3170 3175 3180
Ala Thr Gly Thr Gly Ala Ala Cys Thr Gly Ala Gly Ala Gly Thr Gly
3185 3190 3195 3200
Ala Ala Gly Thr Thr Cys Ala Gly Cys Ala Gly Gly Ala Gly Cys Gly
3205 3210 3215
Cys Ala Gly Ala Cys Gly Cys Cys Cys Cys Cys Gly Cys Gly Thr Ala
3220 3225 3230
Cys Ala Ala Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Ala Ala Cys
3235 3240 3245
Cys Ala Gly Cys Thr Cys Thr Ala Thr Ala Ala Cys Gly Ala Gly Cys
3250 3255 3260
Thr Cys Ala Ala Thr Cys Thr Ala Gly Gly Ala Cys Gly Ala Ala Gly
3265 3270 3275 3280
Ala Gly Ala Gly Gly Ala Gly Thr Ala Cys Gly Ala Thr Gly Thr Thr
3285 3290 3295
Thr Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly Gly Cys Gly Thr Gly
3300 3305 3310
Gly Cys Cys Gly Gly Gly Ala Cys Cys Cys Thr Gly Ala Gly Ala Thr
3315 3320 3325
Gly Gly Gly Gly Gly Gly Ala Ala Ala Gly Cys Cys Gly Ala Gly Ala
3330 3335 3340
Ala Gly Gly Ala Ala Gly Ala Ala Cys Cys Cys Thr Cys Ala Gly Gly
3345 3350 3355 3360
Ala Ala Gly Gly Cys Cys Thr Gly Thr Ala Cys Ala Ala Thr Gly Ala
3365 3370 3375
Ala Cys Thr Gly Cys Ala Gly Ala Ala Ala Gly Ala Thr Ala Ala Gly
3380 3385 3390
Ala Thr Gly Gly Cys Gly Gly Ala Gly Gly Cys Cys Thr Ala Cys Ala
3395 3400 3405
Gly Thr Gly Ala Gly Ala Thr Thr Gly Gly Gly Ala Thr Gly Ala Ala
3410 3415 3420
Ala Gly Gly Cys Gly Ala Gly Cys Gly Cys Cys Gly Gly Ala Gly Gly
3425 3430 3435 3440
Gly Gly Cys Ala Ala Gly Gly Gly Gly Cys Ala Cys Gly Ala Thr Gly
3445 3450 3455
Gly Cys Cys Thr Thr Thr Ala Cys Cys Ala Gly Gly Gly Thr Cys Thr
3460 3465 3470
Cys Ala Gly Thr Ala Cys Ala Gly Cys Cys Ala Cys Cys Ala Ala Gly
3475 3480 3485
Gly Ala Cys Ala Cys Cys Thr Ala Cys Gly Ala Cys Gly Cys Cys Cys
3490 3495 3500
Thr Thr Cys Ala Cys Ala Thr Gly Cys Ala Gly Gly Cys Cys Cys Thr
3505 3510 3515 3520
Gly Cys Cys Cys Cys Cys Thr Cys Gly Cys Thr Ala Ala
3525 3530
<210> 222
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 222
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagcccg agcagcctga 2160
gcgcgagcgt gggtgatcgc gtgaccatta cctgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccgggta aagcgccgaa actgttaatt tatcatacat 2280
caagattaca ctcaggcgtg ccgtcgcgtt ttagcggctc gggttcgggc accgatttta 2340
ccctgaccat ctcgagcttg cagccggagg acttcgccac ctactattgc caacagggta 2400
atacgcttcc gtacacgttc ggtcagggca ccaaagtgga gatcaaaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgca gctggtggag tctgggggag 2520
gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga gtgtccctgc 2580
ctgattatgg cgtgtcctgg gtccgccagg ctccagggaa ggggctggag tgggtttcag 2640
tgatctgggg cagcgagaca acctactaca acagcgccct gaagtcccga ttcaccatct 2700
ccagagacaa tgccaagaac tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca 2760
cggctgtgta ttactgtgcg aagcactact actacggcgg cagctacgct atggactact 2820
ggggccaagg aaccctggtc accgtgtcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc ctttactgca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 223
<211> 3524
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 223
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccga 2160
gcagcctgag cgcgagcgtg ggtgatcgcg tgaccattac ctgcagggca agtcaggaca 2220
ttagtaaata tttaaattgg tatcagcaga aaccgggtaa agcgccgaaa ctgttaattt 2280
atcatacatc aagattacac tcaggcgtgc cgtcgcgttt tagcggctcg ggttcgggca 2340
ccgattttac cctgaccatc tcgagcttgc agccggagga cttcgccacc tactattgcc 2400
aacagggtaa tacgcttccg tacacgttcg gtcagggcac caaagtggag atcaaaggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaggtgcag ctggtggagt 2520
ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca gcctctggag 2580
tgtccctgcc tgattatggc gtgtcctggg tccgccaggc tccagggaag gggctggagt 2640
gggtttcagt gatctggggc agcgagacaa cctactacaa cagcgccctg aagtcccgat 2700
tcaccatctc cagagacaat gccaagaact cactgtatct gcaaatgaac agcctgagag 2760
ccgaggacac ggctgtgtat tactgtgcga agcactacta ctacggcggc agctacgcta 2820
tggactactg gggccaagga accctggtca ccgtgtcctc aaccacgacg ccagcgccgc 2880
gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt 2940
gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc tgtgatatct 3000
acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg gttatcacca 3060
aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga ccagtacaaa 3120
ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa ggaggatgtg 3180
aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag ggccagaacc 3240
agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg gacaagaggc 3300
gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt 3360
acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg atgaaaggcg 3420
agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca gccaccaagg 3480
acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa 3524
<210> 224
<211> 3515
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 224
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagcccg agcagcctga 2160
gcgcgagcgt gggtgatcgc gtgaccatta cctgcagggc aagtcaggac attagtaaat 2220
atttaaattg gtatcagcag aaaccgggta aagcgccgaa actgttaatt tatcatacat 2280
caagattaca ctcaggcgtg ccgtcgcgtt ttagcggctc gggttcgggc accgatttta 2340
ccctgaccat ctcgagcttg cagccggagg acttcgccac ctactattgc caacagggta 2400
atacgcttcc gtacacgttc ggtcagggca ccaaagtgga gatcaaaggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaggtgca gctggtggag tctgggggag 2520
gcttggtaca gcctgggggg tccctgagac tctcctgtgc agcctctgga gtgtccctgc 2580
ctgattatgg cgtgtcctgg gtccgccagg ctccagggaa ggggctggag tgggtttcag 2640
tgatctgggg cagcgagaca acctactaca acagcgccct gaagtcccga ttcaccatct 2700
ccagagacaa tgccaagaac tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca 2760
cggctgtgta ttactgtgcg aagcactact actacggcgg cagctacgct atggactact 2820
ggggccaagg aaccctggtc accgtgtcct caaccacgac gccagcgccg cgaccaccaa 2880
caccggcgcc caccatcgcg tcgcagcccc tgtccctgcg cccagaggcg tgccggccag 2940
cggcgggggg cgcagtgcac acgagggggc tggacttcgc ctgtgatatc tacatctggg 3000
cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc aaacggggca 3060
gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa actactcaag 3120
aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt gaactgagag 3180
tgaagttcag caggagcgca gacgcccccg cgtacaagca gggccagaac cagctctata 3240
acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagagg cgtggccggg 3300
accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg tacaatgaac 3360
tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc gagcgccgga 3420
ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag gacacctacg 3480
acgcccttca catgcaggcc ctgccccctc gctaa 3515
<210> 225
<211> 3545
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 225
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccaa 2160
gctccctgtc cgcctctgtg ggcgacaggg tgaccatcac atgccgcgcc agccagacaa 2220
tctggtccta cctgaactgg tatcagcaga gacccggcaa ggcccctaat ctgctgatct 2280
acgcagcatc tagcctgcag tctggagtgc cctcccggtt ctctggaaga ggatccggaa 2340
ccgacttcac cctgacaatc tcctctctgc aggccgagga cttcgccaca tactattgcc 2400
agcagagcta ttccatccct cagacctttg gccagggcac aaagctggag atcaagggcg 2460
gcggcggctc tggaggagga ggaagcggag gaggaggatc ccaggtgcag ctgcagcaga 2520
gcggaccagg actggtgaag ccctcccaga ccctgtctct gacatgtgcc atcagcggcg 2580
attccgtgag ctccaacagc gccgcctgga attggatccg gcagtctccc agcagaggac 2640
tggagtggct gggaaggacc tactatcgct ccaagtggta caacgattat gccgtgtctg 2700
tgaagagccg gatcaccatc aaccctgaca catctaagaa tcagttcagc ctgcagctga 2760
attccgtgac cccagaggac acagccgtgt actattgtgc aagggaggtg accggcgacc 2820
tggaggatgc ctttgacatc tggggccagg gcaccatggt gacagtgtct agcaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3120
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3180
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3240
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3300
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3360
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3420
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3480
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3540
gctaa 3545
<210> 226
<211> 490
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 226
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
35 40 45
Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala
50 55 60
Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
85 90 95
Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
100 105 110
Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
130 135 140
Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr
145 150 155 160
Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser
165 170 175
Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp
180 185 190
Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val
195 200 205
Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln
210 215 220
Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr
225 230 235 240
Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile
245 250 255
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
325 330 335
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
340 345 350
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
355 360 365
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
370 375 380
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn
385 390 395 400
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
405 410 415
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
420 425 430
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
435 440 445
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
450 455 460
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
465 470 475 480
Ala Leu His Met Gln Ala Leu Pro Pro Arg
485 490
<210> 227
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 227
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagccca agctccctgt 2160
ccgcctctgt gggcgacagg gtgaccatca catgccgcgc cagccagaca atctggtcct 2220
acctgaactg gtatcagcag agacccggca aggcccctaa tctgctgatc tacgcagcat 2280
ctagcctgca gtctggagtg ccctcccggt tctctggaag aggatccgga accgacttca 2340
ccctgacaat ctcctctctg caggccgagg acttcgccac atactattgc cagcagagct 2400
attccatccc tcagaccttt ggccagggca caaagctgga gatcaagggc ggcggcggct 2460
ctggaggagg aggaagcgga ggaggaggat cccaggtgca gctgcagcag agcggaccag 2520
gactggtgaa gccctcccag accctgtctc tgacatgtgc catcagcggc gattccgtga 2580
gctccaacag cgccgcctgg aattggatcc ggcagtctcc cagcagagga ctggagtggc 2640
tgggaaggac ctactatcgc tccaagtggt acaacgatta tgccgtgtct gtgaagagcc 2700
ggatcaccat caaccctgac acatctaaga atcagttcag cctgcagctg aattccgtga 2760
ccccagagga cacagccgtg tactattgtg caagggaggt gaccggcgac ctggaggatg 2820
cctttgacat ctggggccag ggcaccatgg tgacagtgtc tagcaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 228
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 228
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccaa 2160
gctccctgtc cgcctctgtg ggcgacaggg tgaccatcac atgccgcgcc agccagacaa 2220
tctggtccta cctgaactgg tatcagcaga gacccggcaa ggcccctaat ctgctgatct 2280
acgcagcatc tagcctgcag tctggagtgc cctcccggtt ctctggaaga ggatccggaa 2340
ccgacttcac cctgacaatc tcctctctgc aggccgagga cttcgccaca tactattgcc 2400
agcagagcta ttccatccct cagacctttg gccagggcac aaagctggag atcaagggcg 2460
gcggcggctc tggaggagga ggaagcggag gaggaggatc ccaggtgcag ctgcagcaga 2520
gcggaccagg actggtgaag ccctcccaga ccctgtctct gacatgtgcc atcagcggcg 2580
attccgtgag ctccaacagc gccgcctgga attggatccg gcagtctccc agcagaggac 2640
tggagtggct gggaaggacc tactatcgct ccaagtggta caacgattat gccgtgtctg 2700
tgaagagccg gatcaccatc aaccctgaca catctaagaa tcagttcagc ctgcagctga 2760
attccgtgac cccagaggac acagccgtgt actattgtgc aagggaggtg accggcgacc 2820
tggaggatgc ctttgacatc tggggccagg gcaccatggt gacagtgtct agcaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 229
<211> 487
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 229
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
20 25 30
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
35 40 45
Thr Ile Trp Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala
50 55 60
Pro Asn Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
85 90 95
Ser Ser Leu Gln Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
100 105 110
Tyr Ser Ile Pro Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
115 120 125
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln
130 135 140
Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr
145 150 155 160
Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn Ser
165 170 175
Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp
180 185 190
Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val
195 200 205
Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln
210 215 220
Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr
225 230 235 240
Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp Ile
245 250 255
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly
325 330 335
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
340 345 350
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
355 360 365
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
370 375 380
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385 390 395 400
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
405 410 415
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
420 425 430
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
435 440 445
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
450 455 460
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465 470 475 480
Met Gln Ala Leu Pro Pro Arg
485
<210> 230
<211> 3527
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 230
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagccca agctccctgt 2160
ccgcctctgt gggcgacagg gtgaccatca catgccgcgc cagccagaca atctggtcct 2220
acctgaactg gtatcagcag agacccggca aggcccctaa tctgctgatc tacgcagcat 2280
ctagcctgca gtctggagtg ccctcccggt tctctggaag aggatccgga accgacttca 2340
ccctgacaat ctcctctctg caggccgagg acttcgccac atactattgc cagcagagct 2400
attccatccc tcagaccttt ggccagggca caaagctgga gatcaagggc ggcggcggct 2460
ctggaggagg aggaagcgga ggaggaggat cccaggtgca gctgcagcag agcggaccag 2520
gactggtgaa gccctcccag accctgtctc tgacatgtgc catcagcggc gattccgtga 2580
gctccaacag cgccgcctgg aattggatcc ggcagtctcc cagcagagga ctggagtggc 2640
tgggaaggac ctactatcgc tccaagtggt acaacgatta tgccgtgtct gtgaagagcc 2700
ggatcaccat caaccctgac acatctaaga atcagttcag cctgcagctg aattccgtga 2760
ccccagagga cacagccgtg tactattgtg caagggaggt gaccggcgac ctggaggatg 2820
cctttgacat ctggggccag ggcaccatgg tgacagtgtc tagcaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac 3120
aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat 3180
gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga 3240
accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga 3300
ggcgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc 3360
tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag 3420
gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca 3480
aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa 3527
<210> 231
<211> 3545
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 231
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccaa 2160
gctccctgtc cgcctctgtg ggcgacaggg tgaccatcac atgccgcgcc agccagacaa 2220
tctggtccta cctgaactgg tatcagcaga gacccggcaa ggcccctaat ctgctgatct 2280
acgcagcatc tagcctgcag tctggagtgc cctcccggtt ctctggaaga ggatccggaa 2340
ccgacttcac cctgacaatc tcctctctgc aggccgagga cttcgccaca tactattgcc 2400
agcagagcta ttccatccct cagacctttg gccagggcac aaagctggag atcaagggcg 2460
gcggcggctc tggaggagga ggaagcggag gaggaggatc ccaggtgcag ctgcagcaga 2520
gcggaccagg actggtgaag ccctcccaga ccctgtctct gacatgtgcc atcagcggcg 2580
attccgtgag ctccaacagc gccgcctgga attggatccg gcagtctccc agcagaggac 2640
tggagtggct gggaaggacc tactatcgct ccaagtggta caacgattat gccgtgtctg 2700
tgaagagccg gatcaccatc aaccctgaca catctaagaa tcagttcagc ctgcagctga 2760
attccgtgac cccagaggac acagccgtgt actattgtgc aagggaggtg accggcgacc 2820
tggaggatgc ctttgacatc tggggccagg gcaccatggt gacagtgtct agcaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3120
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3180
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3240
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3300
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3360
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3420
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3480
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3540
gctaa 3545
<210> 232
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 232
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagccca agctccctgt 2160
ccgcctctgt gggcgacagg gtgaccatca catgccgcgc cagccagaca atctggtcct 2220
acctgaactg gtatcagcag agacccggca aggcccctaa tctgctgatc tacgcagcat 2280
ctagcctgca gtctggagtg ccctcccggt tctctggaag aggatccgga accgacttca 2340
ccctgacaat ctcctctctg caggccgagg acttcgccac atactattgc cagcagagct 2400
attccatccc tcagaccttt ggccagggca caaagctgga gatcaagggc ggcggcggct 2460
ctggaggagg aggaagcgga ggaggaggat cccaggtgca gctgcagcag agcggaccag 2520
gactggtgaa gccctcccag accctgtctc tgacatgtgc catcagcggc gattccgtga 2580
gctccaacag cgccgcctgg aattggatcc ggcagtctcc cagcagagga ctggagtggc 2640
tgggaaggac ctactatcgc tccaagtggt acaacgatta tgccgtgtct gtgaagagcc 2700
ggatcaccat caaccctgac acatctaaga atcagttcag cctgcagctg aattccgtga 2760
ccccagagga cacagccgtg tactattgtg caagggaggt gaccggcgac ctggaggatg 2820
cctttgacat ctggggccag ggcaccatgg tgacagtgtc tagcaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 233
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 233
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggatat ccagatgacc cagagcccaa 2160
gctccctgtc cgcctctgtg ggcgacaggg tgaccatcac atgccgcgcc agccagacaa 2220
tctggtccta cctgaactgg tatcagcaga gacccggcaa ggcccctaat ctgctgatct 2280
acgcagcatc tagcctgcag tctggagtgc cctcccggtt ctctggaaga ggatccggaa 2340
ccgacttcac cctgacaatc tcctctctgc aggccgagga cttcgccaca tactattgcc 2400
agcagagcta ttccatccct cagacctttg gccagggcac aaagctggag atcaagggcg 2460
gcggcggctc tggaggagga ggaagcggag gaggaggatc ccaggtgcag ctgcagcaga 2520
gcggaccagg actggtgaag ccctcccaga ccctgtctct gacatgtgcc atcagcggcg 2580
attccgtgag ctccaacagc gccgcctgga attggatccg gcagtctccc agcagaggac 2640
tggagtggct gggaaggacc tactatcgct ccaagtggta caacgattat gccgtgtctg 2700
tgaagagccg gatcaccatc aaccctgaca catctaagaa tcagttcagc ctgcagctga 2760
attccgtgac cccagaggac acagccgtgt actattgtgc aagggaggtg accggcgacc 2820
tggaggatgc ctttgacatc tggggccagg gcaccatggt gacagtgtct agcaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 234
<211> 3527
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 234
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggata tccagatgac ccagagccca agctccctgt 2160
ccgcctctgt gggcgacagg gtgaccatca catgccgcgc cagccagaca atctggtcct 2220
acctgaactg gtatcagcag agacccggca aggcccctaa tctgctgatc tacgcagcat 2280
ctagcctgca gtctggagtg ccctcccggt tctctggaag aggatccgga accgacttca 2340
ccctgacaat ctcctctctg caggccgagg acttcgccac atactattgc cagcagagct 2400
attccatccc tcagaccttt ggccagggca caaagctgga gatcaagggc ggcggcggct 2460
ctggaggagg aggaagcgga ggaggaggat cccaggtgca gctgcagcag agcggaccag 2520
gactggtgaa gccctcccag accctgtctc tgacatgtgc catcagcggc gattccgtga 2580
gctccaacag cgccgcctgg aattggatcc ggcagtctcc cagcagagga ctggagtggc 2640
tgggaaggac ctactatcgc tccaagtggt acaacgatta tgccgtgtct gtgaagagcc 2700
ggatcaccat caaccctgac acatctaaga atcagttcag cctgcagctg aattccgtga 2760
ccccagagga cacagccgtg tactattgtg caagggaggt gaccggcgac ctggaggatg 2820
cctttgacat ctggggccag ggcaccatgg tgacagtgtc tagcaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac 3120
aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat 3180
gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga 3240
accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga 3300
ggcgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc 3360
tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag 3420
gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca 3480
aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa 3527
<210> 235
<211> 3665
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 235
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccgatggg ctggtcctgc atcatcctgt 2160
tcctggtggc caccgccacc ggcgtgcact ccaacatcgt gctgacccag tcccccgcct 2220
ccctggccgt gtccctgggc cagcgggcca ccatctcctg ccgggcctcc gagtccgtgg 2280
actcctacgg caactccttc atgcactggt accagcagaa gcccggccag ccccccaagc 2340
tgctgatcta cctggcctcc aacctggagt ccggcgtgcc cgcccggttc tccggctccg 2400
gctcccggac cgacttcacc ctgaccatcg accccgtgga ggccgacgac gtggccacct 2460
actactgcca gcagaacaac ggcgacccct acaccttcgg cggcggcacc aagctggaga 2520
tcatccgggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tccatgggct 2580
ggtcctgcat catcctgttc ctggtggcca ccgccaccgg cgtgcactcc gaggtgcagc 2640
tggtggagtc cggcggcggc ctgatgcagc ccaagggctc cctgaagctg tcctgcgccg 2700
cctccggctt caccttcaag acctacgccc tgaactgggt gcggcaggcc cccggcaccg 2760
gcctggagtg ggtggcccgg atccggtcca agtccaacaa ctacaccacc tactacgccg 2820
actccgtgaa ggaccggttc accatctccc gggacgactc ccagaacatg ctgtacctgc 2880
agatgaacaa cctgaagacc gaggacaccg ccatgtacta ctgcgtgcgg ccccagtccg 2940
gcacctcctt cgcctactgg ggccagggca ccctggtgac cgtgtccgcc gccaccacga 3000
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 3060
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3120
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3180
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3240
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3300
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3360
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3420
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3480
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3540
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3600
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3660
gctaa 3665
<210> 236
<211> 530
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 236
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val
20 25 30
Ala Thr Ala Thr Gly Val His Ser Asn Ile Val Leu Thr Gln Ser Pro
35 40 45
Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg
50 55 60
Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr
65 70 75 80
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser
85 90 95
Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg
100 105 110
Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala
115 120 125
Thr Tyr Tyr Cys Gln Gln Asn Asn Gly Asp Pro Tyr Thr Phe Gly Gly
130 135 140
Gly Thr Lys Leu Glu Ile Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly
145 150 155 160
Gly Ser Gly Gly Gly Gly Ser Met Gly Trp Ser Cys Ile Ile Leu Phe
165 170 175
Leu Val Ala Thr Ala Thr Gly Val His Ser Glu Val Gln Leu Val Glu
180 185 190
Ser Gly Gly Gly Leu Met Gln Pro Lys Gly Ser Leu Lys Leu Ser Cys
195 200 205
Ala Ala Ser Gly Phe Thr Phe Lys Thr Tyr Ala Leu Asn Trp Val Arg
210 215 220
Gln Ala Pro Gly Thr Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys
225 230 235 240
Ser Asn Asn Tyr Thr Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe
245 250 255
Thr Ile Ser Arg Asp Asp Ser Gln Asn Met Leu Tyr Leu Gln Met Asn
260 265 270
Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg Pro Gln
275 280 285
Ser Gly Thr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
290 295 300
Ser Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
305 310 315 320
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
325 330 335
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
340 345 350
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
355 360 365
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
370 375 380
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
385 390 395 400
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
405 410 415
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln
420 425 430
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
435 440 445
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
450 455 460
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
465 470 475 480
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
485 490 495
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
500 505 510
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
515 520 525
Pro Arg
530
<210> 237
<211> 3656
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 237
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccgatgg gctggtcctg catcatcctg ttcctggtgg 2160
ccaccgccac cggcgtgcac tccaacatcg tgctgaccca gtcccccgcc tccctggccg 2220
tgtccctggg ccagcgggcc accatctcct gccgggcctc cgagtccgtg gactcctacg 2280
gcaactcctt catgcactgg taccagcaga agcccggcca gccccccaag ctgctgatct 2340
acctggcctc caacctggag tccggcgtgc ccgcccggtt ctccggctcc ggctcccgga 2400
ccgacttcac cctgaccatc gaccccgtgg aggccgacga cgtggccacc tactactgcc 2460
agcagaacaa cggcgacccc tacaccttcg gcggcggcac caagctggag atcatccggg 2520
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctccatgggc tggtcctgca 2580
tcatcctgtt cctggtggcc accgccaccg gcgtgcactc cgaggtgcag ctggtggagt 2640
ccggcggcgg cctgatgcag cccaagggct ccctgaagct gtcctgcgcc gcctccggct 2700
tcaccttcaa gacctacgcc ctgaactggg tgcggcaggc ccccggcacc ggcctggagt 2760
gggtggcccg gatccggtcc aagtccaaca actacaccac ctactacgcc gactccgtga 2820
aggaccggtt caccatctcc cgggacgact cccagaacat gctgtacctg cagatgaaca 2880
acctgaagac cgaggacacc gccatgtact actgcgtgcg gccccagtcc ggcacctcct 2940
tcgcctactg gggccagggc accctggtga ccgtgtccgc cgccaccacg acgccagcgc 3000
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 3060
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3120
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3180
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3240
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3300
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3360
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3420
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3480
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3540
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3600
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3656
<210> 238
<211> 3656
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 238
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccgatggg ctggtcctgc atcatcctgt 2160
tcctggtggc caccgccacc ggcgtgcact ccaacatcgt gctgacccag tcccccgcct 2220
ccctggccgt gtccctgggc cagcgggcca ccatctcctg ccgggcctcc gagtccgtgg 2280
actcctacgg caactccttc atgcactggt accagcagaa gcccggccag ccccccaagc 2340
tgctgatcta cctggcctcc aacctggagt ccggcgtgcc cgcccggttc tccggctccg 2400
gctcccggac cgacttcacc ctgaccatcg accccgtgga ggccgacgac gtggccacct 2460
actactgcca gcagaacaac ggcgacccct acaccttcgg cggcggcacc aagctggaga 2520
tcatccgggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tccatgggct 2580
ggtcctgcat catcctgttc ctggtggcca ccgccaccgg cgtgcactcc gaggtgcagc 2640
tggtggagtc cggcggcggc ctgatgcagc ccaagggctc cctgaagctg tcctgcgccg 2700
cctccggctt caccttcaag acctacgccc tgaactgggt gcggcaggcc cccggcaccg 2760
gcctggagtg ggtggcccgg atccggtcca agtccaacaa ctacaccacc tactacgccg 2820
actccgtgaa ggaccggttc accatctccc gggacgactc ccagaacatg ctgtacctgc 2880
agatgaacaa cctgaagacc gaggacaccg ccatgtacta ctgcgtgcgg ccccagtccg 2940
gcacctcctt cgcctactgg ggccagggca ccctggtgac cgtgtccgcc gccaccacga 3000
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 3060
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3120
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3180
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3240
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3300
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3360
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3420
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3480
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3540
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3600
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3656
<210> 239
<211> 527
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 239
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val
20 25 30
Ala Thr Ala Thr Gly Val His Ser Asn Ile Val Leu Thr Gln Ser Pro
35 40 45
Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg
50 55 60
Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr
65 70 75 80
Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser
85 90 95
Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg
100 105 110
Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Val Ala
115 120 125
Thr Tyr Tyr Cys Gln Gln Asn Asn Gly Asp Pro Tyr Thr Phe Gly Gly
130 135 140
Gly Thr Lys Leu Glu Ile Ile Arg Gly Gly Gly Gly Ser Gly Gly Gly
145 150 155 160
Gly Ser Gly Gly Gly Gly Ser Met Gly Trp Ser Cys Ile Ile Leu Phe
165 170 175
Leu Val Ala Thr Ala Thr Gly Val His Ser Glu Val Gln Leu Val Glu
180 185 190
Ser Gly Gly Gly Leu Met Gln Pro Lys Gly Ser Leu Lys Leu Ser Cys
195 200 205
Ala Ala Ser Gly Phe Thr Phe Lys Thr Tyr Ala Leu Asn Trp Val Arg
210 215 220
Gln Ala Pro Gly Thr Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys
225 230 235 240
Ser Asn Asn Tyr Thr Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe
245 250 255
Thr Ile Ser Arg Asp Asp Ser Gln Asn Met Leu Tyr Leu Gln Met Asn
260 265 270
Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Val Arg Pro Gln
275 280 285
Ser Gly Thr Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
290 295 300
Ser Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
305 310 315 320
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
325 330 335
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
340 345 350
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
355 360 365
Ser Leu Val Ile Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
370 375 380
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
385 390 395 400
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
405 410 415
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln
420 425 430
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
435 440 445
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
450 455 460
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
465 470 475 480
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
485 490 495
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
500 505 510
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
515 520 525
<210> 240
<211> 3665
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 240
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccgatggg ctggtcctgc atcatcctgt 2160
tcctggtggc caccgccacc ggcgtgcact ccaacatcgt gctgacccag tcccccgcct 2220
ccctggccgt gtccctgggc cagcgggcca ccatctcctg ccgggcctcc gagtccgtgg 2280
actcctacgg caactccttc atgcactggt accagcagaa gcccggccag ccccccaagc 2340
tgctgatcta cctggcctcc aacctggagt ccggcgtgcc cgcccggttc tccggctccg 2400
gctcccggac cgacttcacc ctgaccatcg accccgtgga ggccgacgac gtggccacct 2460
actactgcca gcagaacaac ggcgacccct acaccttcgg cggcggcacc aagctggaga 2520
tcatccgggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tccatgggct 2580
ggtcctgcat catcctgttc ctggtggcca ccgccaccgg cgtgcactcc gaggtgcagc 2640
tggtggagtc cggcggcggc ctgatgcagc ccaagggctc cctgaagctg tcctgcgccg 2700
cctccggctt caccttcaag acctacgccc tgaactgggt gcggcaggcc cccggcaccg 2760
gcctggagtg ggtggcccgg atccggtcca agtccaacaa ctacaccacc tactacgccg 2820
actccgtgaa ggaccggttc accatctccc gggacgactc ccagaacatg ctgtacctgc 2880
agatgaacaa cctgaagacc gaggacaccg ccatgtacta ctgcgtgcgg ccccagtccg 2940
gcacctcctt cgcctactgg ggccagggca ccctggtgac cgtgtccgcc gccaccacga 3000
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 3060
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3120
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3180
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3240
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3300
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3360
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3420
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3480
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3540
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3600
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3660
gctaa 3665
<210> 241
<211> 3656
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 241
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccgatgg gctggtcctg catcatcctg ttcctggtgg 2160
ccaccgccac cggcgtgcac tccaacatcg tgctgaccca gtcccccgcc tccctggccg 2220
tgtccctggg ccagcgggcc accatctcct gccgggcctc cgagtccgtg gactcctacg 2280
gcaactcctt catgcactgg taccagcaga agcccggcca gccccccaag ctgctgatct 2340
acctggcctc caacctggag tccggcgtgc ccgcccggtt ctccggctcc ggctcccgga 2400
ccgacttcac cctgaccatc gaccccgtgg aggccgacga cgtggccacc tactactgcc 2460
agcagaacaa cggcgacccc tacaccttcg gcggcggcac caagctggag atcatccggg 2520
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctccatgggc tggtcctgca 2580
tcatcctgtt cctggtggcc accgccaccg gcgtgcactc cgaggtgcag ctggtggagt 2640
ccggcggcgg cctgatgcag cccaagggct ccctgaagct gtcctgcgcc gcctccggct 2700
tcaccttcaa gacctacgcc ctgaactggg tgcggcaggc ccccggcacc ggcctggagt 2760
gggtggcccg gatccggtcc aagtccaaca actacaccac ctactacgcc gactccgtga 2820
aggaccggtt caccatctcc cgggacgact cccagaacat gctgtacctg cagatgaaca 2880
acctgaagac cgaggacacc gccatgtact actgcgtgcg gccccagtcc ggcacctcct 2940
tcgcctactg gggccagggc accctggtga ccgtgtccgc cgccaccacg acgccagcgc 3000
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 3060
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3120
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3180
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3240
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3300
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3360
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3420
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3480
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3540
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3600
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3656
<210> 242
<211> 3656
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 242
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccgatggg ctggtcctgc atcatcctgt 2160
tcctggtggc caccgccacc ggcgtgcact ccaacatcgt gctgacccag tcccccgcct 2220
ccctggccgt gtccctgggc cagcgggcca ccatctcctg ccgggcctcc gagtccgtgg 2280
actcctacgg caactccttc atgcactggt accagcagaa gcccggccag ccccccaagc 2340
tgctgatcta cctggcctcc aacctggagt ccggcgtgcc cgcccggttc tccggctccg 2400
gctcccggac cgacttcacc ctgaccatcg accccgtgga ggccgacgac gtggccacct 2460
actactgcca gcagaacaac ggcgacccct acaccttcgg cggcggcacc aagctggaga 2520
tcatccgggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tccatgggct 2580
ggtcctgcat catcctgttc ctggtggcca ccgccaccgg cgtgcactcc gaggtgcagc 2640
tggtggagtc cggcggcggc ctgatgcagc ccaagggctc cctgaagctg tcctgcgccg 2700
cctccggctt caccttcaag acctacgccc tgaactgggt gcggcaggcc cccggcaccg 2760
gcctggagtg ggtggcccgg atccggtcca agtccaacaa ctacaccacc tactacgccg 2820
actccgtgaa ggaccggttc accatctccc gggacgactc ccagaacatg ctgtacctgc 2880
agatgaacaa cctgaagacc gaggacaccg ccatgtacta ctgcgtgcgg ccccagtccg 2940
gcacctcctt cgcctactgg ggccagggca ccctggtgac cgtgtccgcc gccaccacga 3000
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 3060
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3120
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3180
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3240
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3300
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3360
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3420
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3480
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3540
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3600
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3656
<210> 243
<211> 3647
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 243
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccgatgg gctggtcctg catcatcctg ttcctggtgg 2160
ccaccgccac cggcgtgcac tccaacatcg tgctgaccca gtcccccgcc tccctggccg 2220
tgtccctggg ccagcgggcc accatctcct gccgggcctc cgagtccgtg gactcctacg 2280
gcaactcctt catgcactgg taccagcaga agcccggcca gccccccaag ctgctgatct 2340
acctggcctc caacctggag tccggcgtgc ccgcccggtt ctccggctcc ggctcccgga 2400
ccgacttcac cctgaccatc gaccccgtgg aggccgacga cgtggccacc tactactgcc 2460
agcagaacaa cggcgacccc tacaccttcg gcggcggcac caagctggag atcatccggg 2520
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctccatgggc tggtcctgca 2580
tcatcctgtt cctggtggcc accgccaccg gcgtgcactc cgaggtgcag ctggtggagt 2640
ccggcggcgg cctgatgcag cccaagggct ccctgaagct gtcctgcgcc gcctccggct 2700
tcaccttcaa gacctacgcc ctgaactggg tgcggcaggc ccccggcacc ggcctggagt 2760
gggtggcccg gatccggtcc aagtccaaca actacaccac ctactacgcc gactccgtga 2820
aggaccggtt caccatctcc cgggacgact cccagaacat gctgtacctg cagatgaaca 2880
acctgaagac cgaggacacc gccatgtact actgcgtgcg gccccagtcc ggcacctcct 2940
tcgcctactg gggccagggc accctggtga ccgtgtccgc cgccaccacg acgccagcgc 3000
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 3060
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3120
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3180
ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac 3240
aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat 3300
gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga 3360
accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga 3420
ggcgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc 3480
tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag 3540
gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca 3600
aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa 3647
<210> 244
<211> 3518
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 244
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagctcacc cagtccccga 2160
gctcgctgtc cgcctccgtg ggagatcggg tcaccatcac gtgccgcgcc agccagtcga 2220
tttcctccta cctgaactgg taccaacaga agcccggaaa agccccgaag cttctcatct 2280
acgccgcctc gagcctgcag tcaggagtgc cctcacggtt ctccggctcc ggttccggta 2340
ctgatttcac cctgaccatt tcctccctgc aaccggagga cttcgctact tactactgcc 2400
agcagtcgta ctccaccccc tacactttcg gacaaggcac caaggtcgaa atcaagggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaagtgcaa ttggtggaat 2520
cagggggagg acttgtgcag cctggaggat cgctgagact gtcatgtgcc gtgtccggct 2580
ttgccctgtc caaccacggg atgtcctggg tccgccgcgc gcctggaaag ggcctcgaat 2640
gggtgtcggg tattgtgtac agcggtagca cctactatgc cgcatccgtg aaggggagat 2700
tcaccatcag ccgggacaac tccaggaaca ctctgtacct ccaaatgaat tcgctgaggc 2760
cagaggacac tgccatctac tactgctccg cgcatggcgg agagtccgac gtctggggac 2820
aggggaccac cgtgaccgtg tctagcacca cgacgccagc gccgcgacca ccaacaccgg 2880
cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg 2940
ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct 3000
tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgcaaacggg 3060
gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta caaactactc 3120
aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga 3180
gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct 3240
ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag aggcgtggcc 3300
gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg 3360
aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc 3420
ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct 3480
acgacgccct tcacatgcag gccctgcccc ctcgctaa 3518
<210> 245
<211> 482
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 245
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
20 25 30
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Gly Gly Gln
35 40 45
Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
50 55 60
Ala Pro Arg Leu Leu Met Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile
65 70 75 80
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
85 90 95
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
100 105 110
Tyr Gln Ser Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
115 120 125
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
130 135 140
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145 150 155 160
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
165 170 175
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
180 185 190
Ser Ala Ile Leu Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
195 200 205
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
210 215 220
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225 230 235 240
Ala Arg Tyr Trp Pro Met Asp Ile Trp Gly Gln Gly Thr Leu Val Thr
245 250 255
Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
260 265 270
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
275 280 285
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
290 295 300
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
305 310 315 320
Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu
325 330 335
Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu
340 345 350
Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys
355 360 365
Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln
370 375 380
Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu
385 390 395 400
Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly
405 410 415
Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
420 425 430
Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
435 440 445
Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser
450 455 460
Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro
465 470 475 480
Pro Arg
<210> 246
<211> 3509
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 246
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagctcac ccagtccccg agctcgctgt 2160
ccgcctccgt gggagatcgg gtcaccatca cgtgccgcgc cagccagtcg atttcctcct 2220
acctgaactg gtaccaacag aagcccggaa aagccccgaa gcttctcatc tacgccgcct 2280
cgagcctgca gtcaggagtg ccctcacggt tctccggctc cggttccggt actgatttca 2340
ccctgaccat ttcctccctg caaccggagg acttcgctac ttactactgc cagcagtcgt 2400
actccacccc ctacactttc ggacaaggca ccaaggtcga aatcaagggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaagtgca attggtggaa tcagggggag 2520
gacttgtgca gcctggagga tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt 2580
ccaaccacgg gatgtcctgg gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg 2640
gtattgtgta cagcggtagc acctactatg ccgcatccgt gaaggggaga ttcaccatca 2700
gccgggacaa ctccaggaac actctgtacc tccaaatgaa ttcgctgagg ccagaggaca 2760
ctgccatcta ctactgctcc gcgcatggcg gagagtccga cgtctgggga caggggacca 2820
ccgtgaccgt gtctagcacc acgacgccag cgccgcgacc accaacaccg gcgcccacca 2880
tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag 2940
tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga 3000
cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga 3060
aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag 3120
atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt 3180
tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc 3240
tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc cgggaccctg 3300
agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga 3360
aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca 3420
aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc 3480
ttcacatgca ggccctgccc cctcgctaa 3509
<210> 247
<211> 3509
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 247
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagctcacc cagtccccga 2160
gctcgctgtc cgcctccgtg ggagatcggg tcaccatcac gtgccgcgcc agccagtcga 2220
tttcctccta cctgaactgg taccaacaga agcccggaaa agccccgaag cttctcatct 2280
acgccgcctc gagcctgcag tcaggagtgc cctcacggtt ctccggctcc ggttccggta 2340
ctgatttcac cctgaccatt tcctccctgc aaccggagga cttcgctact tactactgcc 2400
agcagtcgta ctccaccccc tacactttcg gacaaggcac caaggtcgaa atcaagggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaagtgcaa ttggtggaat 2520
cagggggagg acttgtgcag cctggaggat cgctgagact gtcatgtgcc gtgtccggct 2580
ttgccctgtc caaccacggg atgtcctggg tccgccgcgc gcctggaaag ggcctcgaat 2640
gggtgtcggg tattgtgtac agcggtagca cctactatgc cgcatccgtg aaggggagat 2700
tcaccatcag ccgggacaac tccaggaaca ctctgtacct ccaaatgaat tcgctgaggc 2760
cagaggacac tgccatctac tactgctccg cgcatggcgg agagtccgac gtctggggac 2820
aggggaccac cgtgaccgtg tctagcacca cgacgccagc gccgcgacca ccaacaccgg 2880
cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg 2940
ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct 3000
tggccgggac ttgtggggtc cttctcctgt cactggttat caccaaacgg ggcagaaaga 3060
aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag 3120
atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt 3180
tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc 3240
tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc cgggaccctg 3300
agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga 3360
aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca 3420
aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc 3480
ttcacatgca ggccctgccc cctcgctaa 3509
<210> 248
<211> 479
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 248
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
20 25 30
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Gly Gly Gln
35 40 45
Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
50 55 60
Ala Pro Arg Leu Leu Met Tyr Asp Ala Ser Ile Arg Ala Thr Gly Ile
65 70 75 80
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
85 90 95
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
100 105 110
Tyr Gln Ser Trp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
115 120 125
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
130 135 140
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145 150 155 160
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
165 170 175
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
180 185 190
Ser Ala Ile Leu Ser Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
195 200 205
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
210 215 220
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225 230 235 240
Ala Arg Tyr Trp Pro Met Asp Ile Trp Gly Gln Gly Thr Leu Val Thr
245 250 255
Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
260 265 270
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
275 280 285
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
290 295 300
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
305 310 315 320
Ser Leu Val Ile Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
325 330 335
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
340 345 350
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg
355 360 365
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln
370 375 380
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
385 390 395 400
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
405 410 415
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
420 425 430
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
435 440 445
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
450 455 460
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
465 470 475
<210> 249
<211> 3500
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 249
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagctcac ccagtccccg agctcgctgt 2160
ccgcctccgt gggagatcgg gtcaccatca cgtgccgcgc cagccagtcg atttcctcct 2220
acctgaactg gtaccaacag aagcccggaa aagccccgaa gcttctcatc tacgccgcct 2280
cgagcctgca gtcaggagtg ccctcacggt tctccggctc cggttccggt actgatttca 2340
ccctgaccat ttcctccctg caaccggagg acttcgctac ttactactgc cagcagtcgt 2400
actccacccc ctacactttc ggacaaggca ccaaggtcga aatcaagggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaagtgca attggtggaa tcagggggag 2520
gacttgtgca gcctggagga tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt 2580
ccaaccacgg gatgtcctgg gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg 2640
gtattgtgta cagcggtagc acctactatg ccgcatccgt gaaggggaga ttcaccatca 2700
gccgggacaa ctccaggaac actctgtacc tccaaatgaa ttcgctgagg ccagaggaca 2760
ctgccatcta ctactgctcc gcgcatggcg gagagtccga cgtctgggga caggggacca 2820
ccgtgaccgt gtctagcacc acgacgccag cgccgcgacc accaacaccg gcgcccacca 2880
tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag 2940
tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga 3000
cttgtggggt ccttctcctg tcactggtta tcaccaaacg gggcagaaag aaactcctgt 3060
atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa gatggctgta 3120
gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag ttcagcagga 3180
gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag ctcaatctag 3240
gacgaagaga ggagtacgat gttttggaca agaggcgtgg ccgggaccct gagatggggg 3300
gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga 3360
tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg 3420
atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc 3480
aggccctgcc ccctcgctaa 3500
<210> 250
<211> 3518
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 250
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagctcacc cagtccccga 2160
gctcgctgtc cgcctccgtg ggagatcggg tcaccatcac gtgccgcgcc agccagtcga 2220
tttcctccta cctgaactgg taccaacaga agcccggaaa agccccgaag cttctcatct 2280
acgccgcctc gagcctgcag tcaggagtgc cctcacggtt ctccggctcc ggttccggta 2340
ctgatttcac cctgaccatt tcctccctgc aaccggagga cttcgctact tactactgcc 2400
agcagtcgta ctccaccccc tacactttcg gacaaggcac caaggtcgaa atcaagggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaagtgcaa ttggtggaat 2520
cagggggagg acttgtgcag cctggaggat cgctgagact gtcatgtgcc gtgtccggct 2580
ttgccctgtc caaccacggg atgtcctggg tccgccgcgc gcctggaaag ggcctcgaat 2640
gggtgtcggg tattgtgtac agcggtagca cctactatgc cgcatccgtg aaggggagat 2700
tcaccatcag ccgggacaac tccaggaaca ctctgtacct ccaaatgaat tcgctgaggc 2760
cagaggacac tgccatctac tactgctccg cgcatggcgg agagtccgac gtctggggac 2820
aggggaccac cgtgaccgtg tctagcacca cgacgccagc gccgcgacca ccaacaccgg 2880
cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg 2940
ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct 3000
tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgcaaacggg 3060
gcagaaagaa actcctgtat atattcaaac aaccatttat gagaccagta caaactactc 3120
aagaggaaga tggctgtagc tgccgatttc cagaagaaga agaaggagga tgtgaactga 3180
gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct 3240
ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag aggcgtggcc 3300
gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg 3360
aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc 3420
ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct 3480
acgacgccct tcacatgcag gccctgcccc ctcgctaa 3518
<210> 251
<211> 3509
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 251
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagctcac ccagtccccg agctcgctgt 2160
ccgcctccgt gggagatcgg gtcaccatca cgtgccgcgc cagccagtcg atttcctcct 2220
acctgaactg gtaccaacag aagcccggaa aagccccgaa gcttctcatc tacgccgcct 2280
cgagcctgca gtcaggagtg ccctcacggt tctccggctc cggttccggt actgatttca 2340
ccctgaccat ttcctccctg caaccggagg acttcgctac ttactactgc cagcagtcgt 2400
actccacccc ctacactttc ggacaaggca ccaaggtcga aatcaagggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaagtgca attggtggaa tcagggggag 2520
gacttgtgca gcctggagga tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt 2580
ccaaccacgg gatgtcctgg gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg 2640
gtattgtgta cagcggtagc acctactatg ccgcatccgt gaaggggaga ttcaccatca 2700
gccgggacaa ctccaggaac actctgtacc tccaaatgaa ttcgctgagg ccagaggaca 2760
ctgccatcta ctactgctcc gcgcatggcg gagagtccga cgtctgggga caggggacca 2820
ccgtgaccgt gtctagcacc acgacgccag cgccgcgacc accaacaccg gcgcccacca 2880
tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag 2940
tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga 3000
cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg ggcagaaaga 3060
aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag 3120
atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt 3180
tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc 3240
tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc cgggaccctg 3300
agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga 3360
aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca 3420
aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc 3480
ttcacatgca ggccctgccc cctcgctaa 3509
<210> 252
<211> 3509
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 252
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggacat ccagctcacc cagtccccga 2160
gctcgctgtc cgcctccgtg ggagatcggg tcaccatcac gtgccgcgcc agccagtcga 2220
tttcctccta cctgaactgg taccaacaga agcccggaaa agccccgaag cttctcatct 2280
acgccgcctc gagcctgcag tcaggagtgc cctcacggtt ctccggctcc ggttccggta 2340
ctgatttcac cctgaccatt tcctccctgc aaccggagga cttcgctact tactactgcc 2400
agcagtcgta ctccaccccc tacactttcg gacaaggcac caaggtcgaa atcaagggtg 2460
gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgaagtgcaa ttggtggaat 2520
cagggggagg acttgtgcag cctggaggat cgctgagact gtcatgtgcc gtgtccggct 2580
ttgccctgtc caaccacggg atgtcctggg tccgccgcgc gcctggaaag ggcctcgaat 2640
gggtgtcggg tattgtgtac agcggtagca cctactatgc cgcatccgtg aaggggagat 2700
tcaccatcag ccgggacaac tccaggaaca ctctgtacct ccaaatgaat tcgctgaggc 2760
cagaggacac tgccatctac tactgctccg cgcatggcgg agagtccgac gtctggggac 2820
aggggaccac cgtgaccgtg tctagcacca cgacgccagc gccgcgacca ccaacaccgg 2880
cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg 2940
ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct 3000
tggccgggac ttgtggggtc cttctcctgt cactggttat caccaaacgg ggcagaaaga 3060
aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact caagaggaag 3120
atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg agagtgaagt 3180
tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc tataacgagc 3240
tcaatctagg acgaagagag gagtacgatg ttttggacaa gaggcgtggc cgggaccctg 3300
agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat gaactgcaga 3360
aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc cggaggggca 3420
aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc tacgacgccc 3480
ttcacatgca ggccctgccc cctcgctaa 3509
<210> 253
<211> 3500
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 253
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaca tccagctcac ccagtccccg agctcgctgt 2160
ccgcctccgt gggagatcgg gtcaccatca cgtgccgcgc cagccagtcg atttcctcct 2220
acctgaactg gtaccaacag aagcccggaa aagccccgaa gcttctcatc tacgccgcct 2280
cgagcctgca gtcaggagtg ccctcacggt tctccggctc cggttccggt actgatttca 2340
ccctgaccat ttcctccctg caaccggagg acttcgctac ttactactgc cagcagtcgt 2400
actccacccc ctacactttc ggacaaggca ccaaggtcga aatcaagggt ggcggtggct 2460
cgggcggtgg tgggtcgggt ggcggcggat ctgaagtgca attggtggaa tcagggggag 2520
gacttgtgca gcctggagga tcgctgagac tgtcatgtgc cgtgtccggc tttgccctgt 2580
ccaaccacgg gatgtcctgg gtccgccgcg cgcctggaaa gggcctcgaa tgggtgtcgg 2640
gtattgtgta cagcggtagc acctactatg ccgcatccgt gaaggggaga ttcaccatca 2700
gccgggacaa ctccaggaac actctgtacc tccaaatgaa ttcgctgagg ccagaggaca 2760
ctgccatcta ctactgctcc gcgcatggcg gagagtccga cgtctgggga caggggacca 2820
ccgtgaccgt gtctagcacc acgacgccag cgccgcgacc accaacaccg gcgcccacca 2880
tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag 2940
tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc ttggccggga 3000
cttgtggggt ccttctcctg tcactggtta tcaccaaacg gggcagaaag aaactcctgt 3060
atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa gatggctgta 3120
gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag ttcagcagga 3180
gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag ctcaatctag 3240
gacgaagaga ggagtacgat gttttggaca agaggcgtgg ccgggaccct gagatggggg 3300
gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga 3360
tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg 3420
atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc 3480
aggccctgcc ccctcgctaa 3500
<210> 254
<211> 3545
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 254
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggagat cgtgatgacc cagtcccccc 2160
tgtccctgcc cgtgaccccc ggcgagcccg cctccatctc ctgccggtcc tcccagtccc 2220
tgctgcactc caacggctac aactacctgg actggtacct gcagaagccc ggccagtccc 2280
cccagctgct gatctacctg ggctccaacc gggcctccgg cgtgcccgac cggttctccg 2340
gctccggctc cggcaccgac ttcaccctga agatctcccg ggtggaggcc gaggacgtgg 2400
gcgtgtacta ctgcatgcag gccctgcaga cccccacctt cggccccggc accaaggtgg 2460
acatcaaggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tcccaggtgc 2520
agctggtgca gtccggcggc ggcgtggtgc agcccggcaa gtccctgcgg ctgtcctgcg 2580
ccgcctccgg cttcaccttc tccatcttcg ccatgcactg ggtgcggcag gcccccggca 2640
agggcctgga gtgggtggcc accatctcct acgacggctc caacgccttc tacgccgact 2700
ccgtggaggg ccggttcacc atctcccggg acaactccaa ggactccctg tacctgcaga 2760
tggactccct gcggcccgag gacaccgccg tgtactactg cgtgaaggcc ggcgacggcg 2820
gctacgacgt gttcgactcc tggggccagg gcaccctggt gaccgtgtcc tccaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3120
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3180
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3240
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3300
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3360
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3420
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3480
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3540
gctaa 3545
<210> 255
<211> 490
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 255
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu
20 25 30
Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln
35 40 45
Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln
50 55 60
Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg
65 70 75 80
Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
85 90 95
Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
100 105 110
Tyr Cys Met Gln Ala Leu Gln Thr Pro Thr Phe Gly Pro Gly Thr Lys
115 120 125
Val Asp Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140
Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln
145 150 155 160
Pro Gly Lys Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
165 170 175
Ser Ile Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
180 185 190
Glu Trp Val Ala Thr Ile Ser Tyr Asp Gly Ser Asn Ala Phe Tyr Ala
195 200 205
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp
210 215 220
Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val
225 230 235 240
Tyr Tyr Cys Val Lys Ala Gly Asp Gly Gly Tyr Asp Val Phe Asp Ser
245 250 255
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys
325 330 335
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
340 345 350
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
355 360 365
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg
370 375 380
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn
385 390 395 400
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg
405 410 415
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro
420 425 430
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala
435 440 445
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His
450 455 460
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp
465 470 475 480
Ala Leu His Met Gln Ala Leu Pro Pro Arg
485 490
<210> 256
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 256
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaga tcgtgatgac ccagtccccc ctgtccctgc 2160
ccgtgacccc cggcgagccc gcctccatct cctgccggtc ctcccagtcc ctgctgcact 2220
ccaacggcta caactacctg gactggtacc tgcagaagcc cggccagtcc ccccagctgc 2280
tgatctacct gggctccaac cgggcctccg gcgtgcccga ccggttctcc ggctccggct 2340
ccggcaccga cttcaccctg aagatctccc gggtggaggc cgaggacgtg ggcgtgtact 2400
actgcatgca ggccctgcag acccccacct tcggccccgg caccaaggtg gacatcaagg 2460
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctcccaggtg cagctggtgc 2520
agtccggcgg cggcgtggtg cagcccggca agtccctgcg gctgtcctgc gccgcctccg 2580
gcttcacctt ctccatcttc gccatgcact gggtgcggca ggcccccggc aagggcctgg 2640
agtgggtggc caccatctcc tacgacggct ccaacgcctt ctacgccgac tccgtggagg 2700
gccggttcac catctcccgg gacaactcca aggactccct gtacctgcag atggactccc 2760
tgcggcccga ggacaccgcc gtgtactact gcgtgaaggc cggcgacggc ggctacgacg 2820
tgttcgactc ctggggccag ggcaccctgg tgaccgtgtc ctccaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 257
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 257
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggagat cgtgatgacc cagtcccccc 2160
tgtccctgcc cgtgaccccc ggcgagcccg cctccatctc ctgccggtcc tcccagtccc 2220
tgctgcactc caacggctac aactacctgg actggtacct gcagaagccc ggccagtccc 2280
cccagctgct gatctacctg ggctccaacc gggcctccgg cgtgcccgac cggttctccg 2340
gctccggctc cggcaccgac ttcaccctga agatctcccg ggtggaggcc gaggacgtgg 2400
gcgtgtacta ctgcatgcag gccctgcaga cccccacctt cggccccggc accaaggtgg 2460
acatcaaggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tcccaggtgc 2520
agctggtgca gtccggcggc ggcgtggtgc agcccggcaa gtccctgcgg ctgtcctgcg 2580
ccgcctccgg cttcaccttc tccatcttcg ccatgcactg ggtgcggcag gcccccggca 2640
agggcctgga gtgggtggcc accatctcct acgacggctc caacgccttc tacgccgact 2700
ccgtggaggg ccggttcacc atctcccggg acaactccaa ggactccctg tacctgcaga 2760
tggactccct gcggcccgag gacaccgccg tgtactactg cgtgaaggcc ggcgacggcg 2820
gctacgacgt gttcgactcc tggggccagg gcaccctggt gaccgtgtcc tccaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 258
<211> 487
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 258
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Leu Ser Leu
20 25 30
Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln
35 40 45
Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln
50 55 60
Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg
65 70 75 80
Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
85 90 95
Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr
100 105 110
Tyr Cys Met Gln Ala Leu Gln Thr Pro Thr Phe Gly Pro Gly Thr Lys
115 120 125
Val Asp Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140
Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln
145 150 155 160
Pro Gly Lys Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
165 170 175
Ser Ile Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
180 185 190
Glu Trp Val Ala Thr Ile Ser Tyr Asp Gly Ser Asn Ala Phe Tyr Ala
195 200 205
Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp
210 215 220
Ser Leu Tyr Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val
225 230 235 240
Tyr Tyr Cys Val Lys Ala Gly Asp Gly Gly Tyr Asp Val Phe Asp Ser
245 250 255
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala
260 265 270
Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser
275 280 285
Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr
290 295 300
Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala
305 310 315 320
Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly
325 330 335
Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val
340 345 350
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu
355 360 365
Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp
370 375 380
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
385 390 395 400
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
405 410 415
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
420 425 430
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
435 440 445
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
450 455 460
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
465 470 475 480
Met Gln Ala Leu Pro Pro Arg
485
<210> 259
<211> 3527
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 259
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggatattg tgatgaccca gtccccgtcc tccctgaccg tgaccgcggg cgaaaaagtg 120
accatgattt gcaaatcctc ccagtccctg ctgaattccg gcgatcagaa aaattatctg 180
acctggtatc agcagaaacc gggccagccg ccgaaactgc tgattttttg ggcgtccacc 240
cgtgaatccg gcgtgccgga tcgttttacc ggctccggct ccggcaccga ttttaccctg 300
accatttcct ccgtgcaggc ggaagatctg gcggtgtatt attgccagaa tgattattcc 360
tatccgctga cctttggcgc gggcaccaaa ctggaactga aaggcggcgg cggctccggc 420
ggcggcggct ccggcggcgg cggctcccag gtgcagctgc agcagtccga tgcggaactg 480
gtgaaaccgg gctcctccgt gaaaatttcc tgcaaagcgt ccggctatac ctttaccgat 540
catgcgattc attgggtgaa acagaaaccg gaacagggcc tggaatggat tggccatttt 600
tccccgggca ataccgatat taaatataat gataaattta aaggcaaagc gaccctgacc 660
gtggatcgtt cctcctccac cgcgtatatg cagctgaatt ccctgacctc cgaagattcc 720
gcggtgtatt tttgcaaaac ctccaccttt ttttttgatt attggggcca gggcaccacc 780
ctgaccgtgt cctccaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaga tcgtgatgac ccagtccccc ctgtccctgc 2160
ccgtgacccc cggcgagccc gcctccatct cctgccggtc ctcccagtcc ctgctgcact 2220
ccaacggcta caactacctg gactggtacc tgcagaagcc cggccagtcc ccccagctgc 2280
tgatctacct gggctccaac cgggcctccg gcgtgcccga ccggttctcc ggctccggct 2340
ccggcaccga cttcaccctg aagatctccc gggtggaggc cgaggacgtg ggcgtgtact 2400
actgcatgca ggccctgcag acccccacct tcggccccgg caccaaggtg gacatcaagg 2460
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctcccaggtg cagctggtgc 2520
agtccggcgg cggcgtggtg cagcccggca agtccctgcg gctgtcctgc gccgcctccg 2580
gcttcacctt ctccatcttc gccatgcact gggtgcggca ggcccccggc aagggcctgg 2640
agtgggtggc caccatctcc tacgacggct ccaacgcctt ctacgccgac tccgtggagg 2700
gccggttcac catctcccgg gacaactcca aggactccct gtacctgcag atggactccc 2760
tgcggcccga ggacaccgcc gtgtactact gcgtgaaggc cggcgacggc ggctacgacg 2820
tgttcgactc ctggggccag ggcaccctgg tgaccgtgtc ctccaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac 3120
aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat 3180
gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga 3240
accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga 3300
ggcgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc 3360
tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag 3420
gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca 3480
aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa 3527
<210> 260
<211> 3545
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 260
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggagat cgtgatgacc cagtcccccc 2160
tgtccctgcc cgtgaccccc ggcgagcccg cctccatctc ctgccggtcc tcccagtccc 2220
tgctgcactc caacggctac aactacctgg actggtacct gcagaagccc ggccagtccc 2280
cccagctgct gatctacctg ggctccaacc gggcctccgg cgtgcccgac cggttctccg 2340
gctccggctc cggcaccgac ttcaccctga agatctcccg ggtggaggcc gaggacgtgg 2400
gcgtgtacta ctgcatgcag gccctgcaga cccccacctt cggccccggc accaaggtgg 2460
acatcaaggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tcccaggtgc 2520
agctggtgca gtccggcggc ggcgtggtgc agcccggcaa gtccctgcgg ctgtcctgcg 2580
ccgcctccgg cttcaccttc tccatcttcg ccatgcactg ggtgcggcag gcccccggca 2640
agggcctgga gtgggtggcc accatctcct acgacggctc caacgccttc tacgccgact 2700
ccgtggaggg ccggttcacc atctcccggg acaactccaa ggactccctg tacctgcaga 2760
tggactccct gcggcccgag gacaccgccg tgtactactg cgtgaaggcc ggcgacggcg 2820
gctacgacgt gttcgactcc tggggccagg gcaccctggt gaccgtgtcc tccaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata ttcaaacaac 3120
catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag 3180
aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca gacgcccccg 3240
cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga agagaggagt 3300
acgatgtttt ggacaagagg cgtggccggg accctgagat ggggggaaag ccgagaagga 3360
agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg gaggcctaca 3420
gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc ctttaccagg 3480
gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc ctgccccctc 3540
gctaa 3545
<210> 261
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 261
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaga tcgtgatgac ccagtccccc ctgtccctgc 2160
ccgtgacccc cggcgagccc gcctccatct cctgccggtc ctcccagtcc ctgctgcact 2220
ccaacggcta caactacctg gactggtacc tgcagaagcc cggccagtcc ccccagctgc 2280
tgatctacct gggctccaac cgggcctccg gcgtgcccga ccggttctcc ggctccggct 2340
ccggcaccga cttcaccctg aagatctccc gggtggaggc cgaggacgtg ggcgtgtact 2400
actgcatgca ggccctgcag acccccacct tcggccccgg caccaaggtg gacatcaagg 2460
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctcccaggtg cagctggtgc 2520
agtccggcgg cggcgtggtg cagcccggca agtccctgcg gctgtcctgc gccgcctccg 2580
gcttcacctt ctccatcttc gccatgcact gggtgcggca ggcccccggc aagggcctgg 2640
agtgggtggc caccatctcc tacgacggct ccaacgcctt ctacgccgac tccgtggagg 2700
gccggttcac catctcccgg gacaactcca aggactccct gtacctgcag atggactccc 2760
tgcggcccga ggacaccgcc gtgtactact gcgtgaaggc cggcgacggc ggctacgacg 2820
tgttcgactc ctggggccag ggcaccctgg tgaccgtgtc ctccaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 262
<211> 3536
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 262
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accctttact gcaaacgggg cagaaagaaa 1020
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat 1080
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc 1140
agcaggagcg cagacgcccc cgcgtacaag cagggccaga accagctcta taacgagctc 1200
aatctaggac gaagagagga gtacgatgtt ttggacaaga ggcgtggccg ggaccctgag 1260
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa 1320
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag 1380
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt 1440
cacatgcagg ccctgccccc tcgctaatct agaggcgcgc ccctctccct cccccccccc 1500
taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt 1560
ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt 1620
gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt 1680
cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct 1740
ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt 1800
ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt 1860
ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa 1920
ggtaccccat tgtatgggat ctgatctggg gcctcggtac acatgcttta catgtgttta 1980
gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa 2040
aacacgatga taatatggcc acaacccata tgatggcctt accagtgacc gccttgctcc 2100
tgccgctggc cttgctgctc cacgccgcca ggccggagat cgtgatgacc cagtcccccc 2160
tgtccctgcc cgtgaccccc ggcgagcccg cctccatctc ctgccggtcc tcccagtccc 2220
tgctgcactc caacggctac aactacctgg actggtacct gcagaagccc ggccagtccc 2280
cccagctgct gatctacctg ggctccaacc gggcctccgg cgtgcccgac cggttctccg 2340
gctccggctc cggcaccgac ttcaccctga agatctcccg ggtggaggcc gaggacgtgg 2400
gcgtgtacta ctgcatgcag gccctgcaga cccccacctt cggccccggc accaaggtgg 2460
acatcaaggg cggcggcggc tccggcggcg gcggctccgg cggcggcggc tcccaggtgc 2520
agctggtgca gtccggcggc ggcgtggtgc agcccggcaa gtccctgcgg ctgtcctgcg 2580
ccgcctccgg cttcaccttc tccatcttcg ccatgcactg ggtgcggcag gcccccggca 2640
agggcctgga gtgggtggcc accatctcct acgacggctc caacgccttc tacgccgact 2700
ccgtggaggg ccggttcacc atctcccggg acaactccaa ggactccctg tacctgcaga 2760
tggactccct gcggcccgag gacaccgccg tgtactactg cgtgaaggcc ggcgacggcg 2820
gctacgacgt gttcgactcc tggggccagg gcaccctggt gaccgtgtcc tccaccacga 2880
cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc 2940
gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg ctggacttcg 3000
cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac 3060
tggttatcac caaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga 3120
gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag 3180
aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc gcgtacaagc 3240
agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag tacgatgttt 3300
tggacaagag gcgtggccgg gaccctgaga tggggggaaa gccgagaagg aagaaccctc 3360
aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac agtgagattg 3420
ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag ggtctcagta 3480
cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct cgctaa 3536
<210> 263
<211> 3527
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 263
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcg tgatgaccca gtccccctcc agcctgacag tgacagccgg cgagaaggtg 120
acaatgatct gtaagtccag ccagagcctg ctgaacagcg gcgaccagaa gaactacctg 180
acctggtacc agcagaagcc tggccagccc cccaagctgc tgatcttctg ggccagcaca 240
agggagagcg gcgtgcccga cagattcaca ggcagcggca gcggcaccga cttcacactg 300
accatttcct ccgtgcaggc cgaggacctc gccgtgtact actgccagaa cgactactcc 360
taccccctga cattcggcgc cggcaccaaa ctggagctga agggtggcgg tggctcgggc 420
ggtggtgggt cgggtggcgg cggatctcag gtgcagctcc agcagtccga tgccgagctg 480
gtgaagcccg gaagcagcgt caagatcagc tgtaaggcct ccggctacac cttcacagac 540
cacgccatcc actgggtgaa gcagaagccc gagcagggcc tggagtggat cggccacttt 600
agccccggaa acaccgacat caagtacaac gacaagttca agggcaaggc caccctgacc 660
gtggacagga gcagcagcac cgcctacatg cagctgaaca gcctgacaag cgaggacagc 720
gccgtgtact tctgcaagac ctccaccttc ttcttcgact actggggcca gggaaccacc 780
ctgacagtgt ccagcaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc 840
gcgtcgcagc ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg 900
cacacgaggg ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact 960
tgtggggtcc ttctcctgtc actggttatc accaaacggg gcagaaagaa actcctgtat 1020
atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc 1080
tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc 1140
gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga 1200
cgaagagagg agtacgatgt tttggacaag aggcgtggcc gggaccctga gatgggggga 1260
aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg 1320
gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat 1380
ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag 1440
gccctgcccc ctcgctaatc tagaggcgcg cccctctccc tccccccccc ctaacgttac 1500
tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat 1560
attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat 1620
tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga 1680
agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca 1740
gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac 1800
acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt 1860
caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca 1920
ttgtatggga tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt 1980
aaaaaaacgt ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg 2040
ataatatggc cacaacccat atgatggcct taccagtgac cgccttgctc ctgccgctgg 2100
ccttgctgct ccacgccgcc aggccggaga tcgtgatgac ccagtccccc ctgtccctgc 2160
ccgtgacccc cggcgagccc gcctccatct cctgccggtc ctcccagtcc ctgctgcact 2220
ccaacggcta caactacctg gactggtacc tgcagaagcc cggccagtcc ccccagctgc 2280
tgatctacct gggctccaac cgggcctccg gcgtgcccga ccggttctcc ggctccggct 2340
ccggcaccga cttcaccctg aagatctccc gggtggaggc cgaggacgtg ggcgtgtact 2400
actgcatgca ggccctgcag acccccacct tcggccccgg caccaaggtg gacatcaagg 2460
gcggcggcgg ctccggcggc ggcggctccg gcggcggcgg ctcccaggtg cagctggtgc 2520
agtccggcgg cggcgtggtg cagcccggca agtccctgcg gctgtcctgc gccgcctccg 2580
gcttcacctt ctccatcttc gccatgcact gggtgcggca ggcccccggc aagggcctgg 2640
agtgggtggc caccatctcc tacgacggct ccaacgcctt ctacgccgac tccgtggagg 2700
gccggttcac catctcccgg gacaactcca aggactccct gtacctgcag atggactccc 2760
tgcggcccga ggacaccgcc gtgtactact gcgtgaaggc cggcgacggc ggctacgacg 2820
tgttcgactc ctggggccag ggcaccctgg tgaccgtgtc ctccaccacg acgccagcgc 2880
cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg 2940
cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc gcctgtgata 3000
tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca ctggttatca 3060
ccaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg agaccagtac 3120
aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa gaaggaggat 3180
gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag cagggccaga 3240
accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt ttggacaaga 3300
ggcgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct caggaaggcc 3360
tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt gggatgaaag 3420
gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt acagccacca 3480
aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgctaa 3527
<210> 264
<211> 505
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 264
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
245 250 255
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
260 265 270
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
275 280 285
Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro
290 295 300
Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
305 310 315 320
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
325 330 335
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
340 345 350
Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
355 360 365
Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
370 375 380
Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val
385 390 395 400
Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr
405 410 415
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly
420 425 430
Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr
435 440 445
His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
450 455 460
Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp
465 470 475 480
Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser
500 505
<210> 265
<211> 505
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 265
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
245 250 255
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
260 265 270
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
275 280 285
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
290 295 300
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
305 310 315 320
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
325 330 335
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
340 345 350
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
355 360 365
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
370 375 380
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
385 390 395 400
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
405 410 415
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
420 425 430
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
435 440 445
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
450 455 460
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
465 470 475 480
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser
500 505
<210> 266
<211> 69
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 266
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
35 40 45
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
50 55 60
Ile Thr Leu Tyr Cys
65
<210> 267
<211> 66
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 267
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
1 5 10 15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
20 25 30
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile
35 40 45
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val
50 55 60
Ile Thr
65
<210> 268
<211> 69
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 268
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
50 55 60
Ser Leu Val Ile Thr
65
<210> 269
<211> 72
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 269
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
50 55 60
Ser Leu Val Ile Thr Leu Tyr Cys
65 70
<210> 270
<211> 728
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 270
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
245 250 255
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
260 265 270
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
275 280 285
Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro
290 295 300
Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
305 310 315 320
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
325 330 335
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
340 345 350
Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
355 360 365
Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
370 375 380
Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val
385 390 395 400
Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr
405 410 415
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly
420 425 430
Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr
435 440 445
His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
450 455 460
Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp
465 470 475 480
Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
500 505 510
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
515 520 525
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
530 535 540
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
545 550 555 560
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
565 570 575
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
580 585 590
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
595 600 605
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
610 615 620
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
625 630 635 640
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
645 650 655
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
660 665 670
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
675 680 685
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
690 695 700
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
705 710 715 720
His Met Gln Ala Leu Pro Pro Arg
725
<210> 271
<211> 725
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 271
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
245 250 255
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
260 265 270
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
275 280 285
Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro
290 295 300
Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
305 310 315 320
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
325 330 335
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
340 345 350
Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
355 360 365
Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
370 375 380
Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val
385 390 395 400
Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr
405 410 415
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly
420 425 430
Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr
435 440 445
His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
450 455 460
Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp
465 470 475 480
Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
500 505 510
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
515 520 525
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
530 535 540
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
545 550 555 560
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly Arg Lys
565 570 575
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
580 585 590
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
595 600 605
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
610 615 620
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
625 630 635 640
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro
645 650 655
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr
660 665 670
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly
675 680 685
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
690 695 700
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln
705 710 715 720
Ala Leu Pro Pro Arg
725
<210> 272
<211> 728
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 272
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
245 250 255
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
260 265 270
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
275 280 285
Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro
290 295 300
Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
305 310 315 320
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
325 330 335
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
340 345 350
Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
355 360 365
Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
370 375 380
Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val
385 390 395 400
Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr
405 410 415
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly
420 425 430
Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr
435 440 445
His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
450 455 460
Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp
465 470 475 480
Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Pro Thr Thr Thr Pro
500 505 510
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
515 520 525
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
530 535 540
Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
545 550 555 560
Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg
565 570 575
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
580 585 590
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
595 600 605
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
610 615 620
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
625 630 635 640
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
645 650 655
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
660 665 670
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
675 680 685
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
690 695 700
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
705 710 715 720
His Met Gln Ala Leu Pro Pro Arg
725
<210> 273
<211> 731
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 273
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
1 5 10 15
Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
20 25 30
Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
35 40 45
Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val
50 55 60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65 70 75 80
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
85 90 95
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
100 105 110
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ser
130 135 140
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His
145 150 155 160
Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln Gly Leu Glu Trp Ile
165 170 175
Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys Tyr Asn Asp Lys Phe
180 185 190
Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr
195 200 205
Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
210 215 220
Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu
225 230 235 240
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
245 250 255
Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val
260 265 270
Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu
275 280 285
Leu His Ser Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro
290 295 300
Gly Leu Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser
305 310 315 320
Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr
325 330 335
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
340 345 350
Ala Gln Asn Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
355 360 365
Glu Ile Lys Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
370 375 380
Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val
385 390 395 400
Gln Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr
405 410 415
Phe Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly
420 425 430
Leu Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr
435 440 445
His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp
450 455 460
Ser Lys Ser Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp
465 470 475 480
Thr Gly Ile Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Pro Thr Thr Thr Pro
500 505 510
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
515 520 525
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
530 535 540
Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
545 550 555 560
Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
565 570 575
Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe
580 585 590
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg
595 600 605
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser
610 615 620
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr
625 630 635 640
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys
645 650 655
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
660 665 670
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu
675 680 685
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly
690 695 700
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
705 710 715 720
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
725 730
<210> 274
<211> 728
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 274
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
245 250 255
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
260 265 270
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
275 280 285
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
290 295 300
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
305 310 315 320
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
325 330 335
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
340 345 350
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
355 360 365
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
370 375 380
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
385 390 395 400
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
405 410 415
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
420 425 430
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
435 440 445
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
450 455 460
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
465 470 475 480
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
500 505 510
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
515 520 525
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
530 535 540
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
545 550 555 560
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg
565 570 575
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
580 585 590
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
595 600 605
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
610 615 620
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
625 630 635 640
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
645 650 655
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
660 665 670
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
675 680 685
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
690 695 700
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
705 710 715 720
His Met Gln Ala Leu Pro Pro Arg
725
<210> 275
<211> 725
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 275
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
245 250 255
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
260 265 270
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
275 280 285
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
290 295 300
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
305 310 315 320
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
325 330 335
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
340 345 350
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
355 360 365
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
370 375 380
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
385 390 395 400
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
405 410 415
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
420 425 430
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
435 440 445
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
450 455 460
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
465 470 475 480
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg
500 505 510
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
515 520 525
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
530 535 540
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
545 550 555 560
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly Arg Lys
565 570 575
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr
580 585 590
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu
595 600 605
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro
610 615 620
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly
625 630 635 640
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro
645 650 655
Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr
660 665 670
Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly
675 680 685
Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln
690 695 700
Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln
705 710 715 720
Ala Leu Pro Pro Arg
725
<210> 276
<211> 728
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 276
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
245 250 255
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
260 265 270
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
275 280 285
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
290 295 300
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
305 310 315 320
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
325 330 335
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
340 345 350
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
355 360 365
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
370 375 380
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
385 390 395 400
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
405 410 415
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
420 425 430
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
435 440 445
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
450 455 460
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
465 470 475 480
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Pro Thr Thr Thr Pro
500 505 510
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
515 520 525
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
530 535 540
Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
545 550 555 560
Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg
565 570 575
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
580 585 590
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
595 600 605
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
610 615 620
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
625 630 635 640
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
645 650 655
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
660 665 670
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
675 680 685
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
690 695 700
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
705 710 715 720
His Met Gln Ala Leu Pro Pro Arg
725
<210> 277
<211> 731
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 277
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly
1 5 10 15
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30
Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser
35 40 45
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile
65 70 75 80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn
85 90 95
Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
100 105 110
Arg Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
115 120 125
Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
130 135 140
Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn
145 150 155 160
Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp
165 170 175
Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala
180 185 190
Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser
195 200 205
Ser Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile
210 215 220
Tyr Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
225 230 235 240
Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
245 250 255
Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu
260 265 270
Thr Val Thr Ala Gly Glu Lys Val Thr Met Ile Cys Lys Ser Ser Gln
275 280 285
Ser Leu Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln
290 295 300
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr
305 310 315 320
Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr
325 330 335
Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val
340 345 350
Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly
355 360 365
Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
370 375 380
Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu
385 390 395 400
Val Lys Pro Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr
405 410 415
Thr Phe Thr Asp His Ala Ile His Trp Val Lys Gln Lys Pro Glu Gln
420 425 430
Gly Leu Glu Trp Ile Gly His Phe Ser Pro Gly Asn Thr Asp Ile Lys
435 440 445
Tyr Asn Asp Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser
450 455 460
Ser Ser Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser
465 470 475 480
Ala Val Tyr Phe Cys Lys Thr Ser Thr Phe Phe Phe Asp Tyr Trp Gly
485 490 495
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Pro Thr Thr Thr Pro
500 505 510
Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu
515 520 525
Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His
530 535 540
Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu
545 550 555 560
Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr
565 570 575
Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe
580 585 590
Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg
595 600 605
Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser
610 615 620
Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr
625 630 635 640
Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys
645 650 655
Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn
660 665 670
Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu
675 680 685
Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly
690 695 700
His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr
705 710 715 720
Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
725 730
<210> 278
<211> 5
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 278
Gly Gly Gly Gly Ser
1 5
<210> 279
<211> 1470
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 279
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccgcagtccg tgctgaccca gccaccttcc gtgtctgccg ctccaggcca gaaggtgaca 120
atcagctgct ccggcagctc ctctgacatc ggaagcaact acgtgtcctg gtaccagcag 180
ttcccaggca ccgcccccaa gctgctgatc tacgacaaca acaagaggcc tagcgccatc 240
ccagatagat tttctggcag caagtccgga acctccgcca cactgggcat caccggactg 300
cagacaggcg acgaggctga ttactactgc ggcacatggg attccaggct gggaatcgcc 360
gtgttcggag gaggaaccca gctgacagtg ctgggcggag gaggaggaag cggaggagga 420
ggatccggag gaggaggatc tgaggtgcag ctggtgcagt ctggcgccga ggtgaagaag 480
cctggacagt ctctgaagat cagctgtaag gcttccggct actctctgac cgacaactgg 540
atcggatggg tgcggcagaa gccaggcaag ggactggagt ggatgggcat catctaccca 600
ggagactctg atacacgcta ctctcccagc tttcagggcc aggtgaccat ctccgccgat 660
aagtctatca acacagctta cctgcagtgg agctccctga aggccagcga caccgctatc 720
tactactgcg tgggcctgga ttggaactac aacccactga ggtactgggg acctggaacc 780
ctggtgacag tgtctagcac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc 840
atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca 900
gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg 960
acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag 1020
aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa 1080
gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag 1140
ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag 1200
ctcaatctag gacgaagaga ggagtacgat gttttggaca agaggcgtgg ccgggaccct 1260
gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag 1320
aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc 1380
aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc 1440
cttcacatgc aggccctgcc ccctcgctaa 1470
<210> 280
<211> 196
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 280
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 281
<211> 196
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 281
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Glu Arg Tyr Val Glu Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Leu Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 282
<211> 196
<212> PRT
<213> 黄杆菌（Flavobacterium ameridies）
<400> 282
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His
1 5 10 15
Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala
20 25 30
Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe
35 40 45
Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg
50 55 60
Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly
65 70 75 80
Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile
85 90 95
Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Lys Glu Asn Gln Thr Arg
100 105 110
Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser
115 120 125
Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn
130 135 140
Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Lys Thr Asn Cys Asn Gly
145 150 155 160
Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys
165 170 175
Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly
180 185 190
Glu Ile Asn Phe
195
<210> 283
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 283
ggctcctgct gcatcgtagc tgct 24
<210> 284
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 284
Gln Arg Ala Ser Leu Thr Arg
1 5
<210> 285
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 285
agctgcccct tcgcggacgt ggcc 24
<210> 286
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 286
Asp Arg Ser Asn Leu Thr Arg
1 5
<210> 287
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 287
Arg Ser Asp Ala Leu Ser Arg
1 5
<210> 288
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 288
Glu Arg Gly Thr Leu Ala Arg
1 5
<210> 289
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 289
tgccgcccct actgtggaga tgga 24
<210> 290
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 290
Thr Ser Gly Asn Leu Val Arg
1 5
<210> 291
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 291
Gln Ser Gly His Leu Ala Arg
1 5
<210> 292
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 292
Arg Ser Asp Asp Leu Gln Arg
1 5
<210> 293
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 293
accatcaaca gactggaagt gggg 24
<210> 294
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 294
Gln Thr Val Asn Leu Asp Arg
1 5
<210> 295
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 295
Lys Lys Asp His Leu His Arg
1 5
<210> 296
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 296
agctgcccct tcgcggacgt ggcc 24
<210> 297
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 297
His His Asn Ser Leu Thr Arg
1 5
<210> 298
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 298
Met Lys His His Leu Asp Ala
1 5
<210> 299
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 299
Asp Pro Ser Asn Leu Arg Arg
1 5
<210> 300
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 300
Arg Arg Glu Val Leu Glu Asn
1 5
<210> 301
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 301
Gln Ser Gly Ser Leu Thr Arg
1 5
<210> 302
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 302
Asp Arg Ser Asp Leu Thr Arg
1 5
<210> 303
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 303
Gln Ser Ser Ala Leu Thr Arg
1 5
<210> 304
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 304
tgcggcaacc tacatgatgg ggaa 24
<210> 305
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 305
Gln Arg Ser Asn Leu Val Arg
1 5
<210> 306
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 306
Arg Ser Asp His Leu Thr Arg
1 5
<210> 307
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 307
Thr Ser Ala Asn Leu Ser Arg
1 5
<210> 308
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 308
Gln Ser Ser Asp Leu Thr Arg
1 5
<210> 309
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 309
Arg Ser Asp Asn Leu Ala Arg
1 5
<210> 310
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 310
Gln Ser Gly His Leu Gln Arg
1 5
<210> 311
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 311
agcctctcca gccaggggct gag 23
<210> 312
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 312
Arg Ser Asp His Leu Ser Arg
1 5
<210> 313
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 313
Arg Ser Asp His Leu Ala Arg
1 5
<210> 314
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 314
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 315
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 315
Arg Ser Asp Asp Leu Thr Arg
1 5
<210> 316
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 316
Arg Ser Asp Ala Leu Thr Arg
1 5
<210> 317
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 317
Thr Ser Gly His Leu Val Arg
1 5
<210> 318
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 318
Gln Ser Ser Asp Leu Gln Arg
1 5
<210> 319
<211> 24
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 319
ccctgccgcc tgcctgctgg tgtg 24
<210> 320
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 320
Gly Gly Thr Ala Leu Arg Met
1 5
<210> 321
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 321
Gln Arg Ser Ser Leu Val Arg
1 5
<210> 322
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 322
Gln Arg Asn Asn Leu Gly Arg
1 5
<210> 323
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 323
Arg Lys Arg Asn Leu Ile Met
1 5
<210> 324
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 324
Val Arg His Asn Leu Thr Arg
1 5
<210> 325
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 325
Arg Gly Asp Lys Leu Gly Pro
1 5
<210> 326
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 326
gtttacttcc tttgggggga ttgc 24
<210> 327
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 327
Ser Arg Phe Thr Leu Gly Arg
1 5
<210> 328
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 328
Arg Arg Glu His Leu Val Arg
1 5
<210> 329
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 329
Gln Thr Ala Thr Leu Lys Arg
1 5
<210> 330
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 330
Lys His Ser Asn Leu Ala Arg
1 5
<210> 331
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 331
Gln Ser Thr Thr Leu Lys Arg
1 5
<210> 332
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 332
Arg Ala Asp Gly Leu Gln Leu
1 5
<210> 333
<211> 24
<212> DNA
<213> 人工序列（Artificial Sequence）
<400> 333
cacccctgca ccgactcggc agag 24
<210> 334
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 334
Thr Arg Gln Lys Leu Glu Thr
1 5
<210> 335
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 335
Arg Gln Asp Asn Leu Gly Arg
1 5
<210> 336
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 336
Gln Gln His Gly Leu Arg His
1 5
<210> 337
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 337
Thr Lys Lys Ile Leu Thr Val
1 5
<210> 338
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 338
His Lys Ser Ser Leu Thr Arg
1 5
<210> 339
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 339
Arg Ser Asp His Leu Ser Leu
1 5
<210> 340
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 340
accctcacaa cctttgggtt gtc 23
<210> 341
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 341
Arg Lys His His Leu Gly Arg
1 5
<210> 342
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 342
Val Ser Asn Ser Leu Ala Arg
1 5
<210> 343
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 343
Arg Thr Ser Ser Leu Lys Arg
1 5
<210> 344
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 344
Gln Arg Ser Asp Leu Thr Arg
1 5
<210> 345
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 345
Arg Ser Asp Gly Leu Arg Gly
1 5
<210> 346
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 346
ccccccagca ccctttcggc tgtg 24
<210> 347
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 347
Asp Ser Pro Thr Leu Arg Arg
1 5
<210> 348
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 348
Gln Ser Ala His Leu Lys Arg
1 5
<210> 349
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 349
Gln Asp Val Ser Leu Val Arg
1 5
<210> 350
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 350
Met Lys Asn Thr Leu Thr Arg
1 5
<210> 351
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 351
Gln Ser Gly Thr Leu Thr Arg
1 5
<210> 352
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 352
ggctcctgct gcatcgtagc tgct 24
<210> 353
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 353
Thr Lys Gln Ile Leu Gly Arg
1 5
<210> 354
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 354
Arg Thr Glu His Leu Ala Arg
1 5
<210> 355
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 355
Lys Arg Arg Asp Leu Asp Arg
1 5
<210> 356
<211> 245
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 356
Gln Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg
1 5 10 15
Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Ser Ser Trp Leu Ala
20 25 30
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr
35 40 45
Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly
50 55 60
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp
65 70 75 80
Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Tyr Ser Phe Pro Arg Thr Phe
85 90 95
Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly
100 105 110
Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly
115 120 125
Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val
130 135 140
Ser Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ile Trp Ile Arg
145 150 155 160
Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Asn
165 170 175
Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser
180 185 190
Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr
195 200 205
Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Ile Thr Met
210 215 220
Ile Arg Gly Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr
225 230 235 240
Val Thr Val Ser Ser
245
<210> 357
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 357
Arg Thr Ser Ser Leu Lys Arg
1 5
<210> 358
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 358
Gln Arg Ser Asp Leu Thr Arg
1 5
<210> 359
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 359
Arg Ser Asp His Leu Ser Leu
1 5
<210> 360
<211> 25
<212> DNA
<213> 智人（Homo sapiens）
<400> 360
cacagcccaa gatagttaag tgggg 25
<210> 361
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 361
Lys Lys Asp His Leu His Arg
1 5
<210> 362
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 362
Arg Arg Glu Val Leu Glu Asn
1 5
<210> 363
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 363
Gln Arg Gly Asn Leu Asn Met
1 5
<210> 364
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 364
Val Pro Ser Lys Leu Lys Arg
1 5
<210> 365
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 365
Glu Ala His His Leu Ser Arg
1 5
<210> 366
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 366
Gln Asp Gly Asn Leu Thr Arg
1 5
<210> 367
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 367
Thr Ser Thr Leu Leu Asn Arg
1 5
<210> 368
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 368
Gln Gln Thr Asn Leu Thr Arg
1 5
<210> 369
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 369
Val Gly Asn Ser Leu Thr Arg
1 5
<210> 370
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 370
Gln Ser Gly Ser Leu Thr Arg
1 5
<210> 371
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 371
Thr Ser Gly Asn Leu Val Arg
1 5
<210> 372
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 372
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 373
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 373
Arg Ser Asp Asn Leu Ala Arg
1 5
<210> 374
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 374
Asp Arg Ser Asp Leu Thr Arg
1 5
<210> 375
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 375
Gln Ser Gly His Leu Gln Arg
1 5
<210> 376
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 376
Asp Arg Ser His Leu Thr Arg
1 5
<210> 377
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 377
Arg Ser Asp Ala Leu Ser Arg
1 5
<210> 378
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 378
Gln Ser Ser Asp Leu Gln Arg
1 5
<210> 379
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 379
Glu Arg Gly Thr Leu Ala Arg
1 5
<210> 380
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 380
Arg Ser Asp Asp Leu Gln Arg
1 5
<210> 381
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 381
Arg Ser Asp Ala Leu Thr Arg
1 5
<210> 382
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 382
Arg Ser Asp His Leu Ala Arg
1 5
<210> 383
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 383
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 384
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 384
Gln Ser Gly His Leu Gln Arg
1 5
<210> 385
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 385
Gln Ser Ser Asp Leu Thr Arg
1 5
<210> 386
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 386
Gln Ser Ser Asp Leu Thr Arg
1 5
<210> 387
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 387
Arg Ser Asp His Leu Ser Arg
1 5
<210> 388
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 388
Gln Ser Gly His Leu Ala Arg
1 5
<210> 389
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 389
Asp Arg Ser Asp Leu Thr Arg
1 5
<210> 390
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 390
Gln Ser Gly Asn Leu Ala Arg
1 5
<210> 391
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 391
Asp Arg Ser His Leu Thr Arg
1 5
<210> 392
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 392
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 393
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 393
Gln Ser Gly His Leu Gln Arg
1 5
<210> 394
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 394
Arg Ser His Ile Leu Thr Asn
1 5
<210> 395
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 395
Gln Ser Thr Thr Leu Lys Arg
1 5
<210> 396
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 396
Asp Gly Gly His Leu Thr Arg
1 5
<210> 397
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 397
Arg Gln Met Asn Leu Asp Arg
1 5
<210> 398
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 398
Arg Gln Asp Asn Leu Gly Arg
1 5
<210> 399
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 399
Asp Lys Ser Val Leu Ala Arg
1 5
<210> 400
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 400
gccaccttcc cccagctgaa gtc 23
<210> 401
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 401
tgcatctgcg acgtgggagc cgag 24
<210> 402
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 402
gcccacagcc actcgtggcg gcc 23
<210> 403
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 403
ccctgctccc tccgggggct gct 23
<210> 404
<211> 23
<212> DNA
<213> 智人（Homo sapiens）
<400> 404
tccggcttct ccatggagca ggc 23
<210> 405
<211> 24
<212> DNA
<213> 智人（Homo sapiens）
<400> 405
cactgcgccc acgaggccga ggag 24
<210> 406
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 406
His Lys Trp Val Leu Arg Gln
1 5
<210> 407
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 407
Asp Arg Ser Asn Leu Thr Arg
1 5
<210> 408
<211> 19
<212> DNA
<213> 智人（Homo sapiens）
<400> 408
gttgctccag gccacagca 19
<210> 409
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 409
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 410
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 410
Gln Trp Gly Thr Arg Tyr Arg
1 5
<210> 411
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 411
Glu Arg Gly Thr Leu Ala Arg
1 5
<210> 412
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 412
Gln Ser Gly Asp Leu Thr Arg
1 5
<210> 413
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 413
Thr Ser Gly Ala Leu Thr Arg
1 5
<210> 414
<211> 12
<212> DNA
<213> 智人（Homo sapiens）
<400> 414
gactttgcat gt 12
<210> 415
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 415
Trp Arg Ser Ser Leu Ala Ser
1 5
<210> 416
<211> 7
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 416
Gln Ser Gly Ser Leu Thr Arg
1 5
<210> 417
<211> 9
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 417
Thr Gly Pro Gly Ala Ala Ala Arg Ala
1 5
<210> 418
<211> 5
<212> PRT
<213> 人工序列（Artificial Sequence）
<400> 418
Leu Arg Gly Ser Gln
1 5
<210> 419
<211> 18
<212> DNA
<213> 智人（Homo sapiens）
<400> 419
ctccagccag gtccatct 18
<210> 420
<211> 17
<212> DNA
<213> 智人（Homo sapiens）
<400> 420
tctccagcca ggtccat 17
<210> 421
<211> 15
<212> DNA
<213> 智人（Homo sapiens）
<400> 421
tcagcaggct gttgt 15
<210> 422
<211> 17
<212> DNA
<213> 智人（Homo sapiens）
<400> 422
tcagcaggct gttgtgt 17
<210> 423
<211> 15
<212> DNA
<213> 智人（Homo sapiens）
<400> 423
ccctggtctc ttcat 15
<210> 424
<211> 16
<212> DNA
<213> 智人（Homo sapiens）
<400> 424
aagcctccct ggtctt 16
<210> 425
<211> 15
<212> DNA
<213> 智人（Homo sapiens）
<400> 425
aagcctccct ggtct 15
<210> 426
<211> 17
<212> DNA
<213> 智人（Homo sapiens）
<400> 426
gctgaccccc tgtgcct 17
<210> 427
<211> 16
<212> DNA
<213> 智人（Homo sapiens）
<400> 427
gaccccctgt gcctct 16

Claims (5)

1. 一种组合物，其包含T细胞群，所述T细胞包含第一CAR和第二CAR，其中所述第一CAR的结合结构域结合WBC的细胞表面分子，所述第二CAR的结合结构域结合不同于所述WBC的所述细胞表面分子的实体瘤抗原，所述细胞表面分子为CD19，所述实体瘤抗原为MUC1，所述第一CAR包含SEQ ID NO: 5的氨基酸序列；所述第二CAR包含SEQ ID NO: 70的氨基酸序列。
2.根据权利要求1所述的组合物，其中所述第一CAR包含第一抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域；并且所述第二CAR包含第二抗原结合结构域、跨膜结构域、共刺激结构域和CD3ζ结构域。
3.根据权利要求2所述的组合物，其中所述共刺激结构域包括以下的细胞内结构域：CD27、CD28、4-1BB、OX40、CD30、CD40、PD-1、ICOS、淋巴细胞功能相关抗原-1（LFA-1）、CD2、CD7、LIGHT、NKG2C、B7-H3、与CD83特异性结合的配体、或其组合。
4.根据权利要求1所述的组合物，其中所述第一CAR和所述第二CAR被表达为单独的多肽。
5.根据权利要求1-4中任一项所述的组合物在制备治疗受试者肿瘤的药物中的应用，其中所述肿瘤为乳癌或胰腺癌。
CN201980007920.7A 2018-01-11 2019-01-10 修饰细胞的扩增及其用途 Active CN112088008B (zh)

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