KR20140024365A - 조성물 - Google Patents
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- KR20140024365A KR20140024365A KR1020137029372A KR20137029372A KR20140024365A KR 20140024365 A KR20140024365 A KR 20140024365A KR 1020137029372 A KR1020137029372 A KR 1020137029372A KR 20137029372 A KR20137029372 A KR 20137029372A KR 20140024365 A KR20140024365 A KR 20140024365A
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- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2011/000614 | 2011-04-08 | ||
| CN2011000614 | 2011-04-08 | ||
| US201161561044P | 2011-11-17 | 2011-11-17 | |
| US61/561,044 | 2011-11-17 | ||
| PCT/IB2012/051660 WO2012137147A1 (en) | 2011-04-08 | 2012-04-04 | Compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140024365A true KR20140024365A (ko) | 2014-02-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137029372A Withdrawn KR20140024365A (ko) | 2011-04-08 | 2012-04-04 | 조성물 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20140031272A1 (https=) |
| EP (1) | EP2694537A1 (https=) |
| JP (1) | JP6027092B2 (https=) |
| KR (1) | KR20140024365A (https=) |
| AR (1) | AR085845A1 (https=) |
| AU (1) | AU2012241055A1 (https=) |
| BR (1) | BR112013025811A2 (https=) |
| CA (1) | CA2830579A1 (https=) |
| MX (1) | MX2013011617A (https=) |
| RU (1) | RU2013149861A (https=) |
| WO (1) | WO2012137147A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190028754A (ko) * | 2016-07-12 | 2019-03-19 | 까르비오 | 신규한 에스테라아제 및 그의 용도 |
| WO2023200284A1 (ko) * | 2022-04-15 | 2023-10-19 | 재단법인대구경북과학기술원 | 생체 시료 내 지질 연관 단백질의 질량 분석을 위한 지질 연관 단백질의 정제 및 농축 방법 |
Families Citing this family (294)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2619051C2 (ru) | 2011-11-25 | 2017-05-11 | Новозимс А/С | Полипептиды с лизоцимной активностью и полинуклеотиды, кодирующие их |
| US9809787B2 (en) | 2011-12-29 | 2017-11-07 | Novozymes A/S | Detergent compositions comprising lipase |
| BR112014017919A2 (pt) | 2012-01-26 | 2017-06-27 | Novozymes As | uso de um poliptídeo variante, composição, polinucleotídeo isolado, constructo de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos de produção do pilipeptídeo, para melhoria do valor nutricional de uma ração animal, e para o tratamento de proteínas, planta, parte de planta ou célula de planta transgênica, aditivo de ração animal, ração animal, e, composição de ração animal ou detergente |
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| DK2847308T3 (en) | 2012-05-07 | 2017-10-23 | Novozymes As | Polypeptides with xanthan-degrading activity and polynucleotides encoding them |
| WO2013171241A1 (en) | 2012-05-16 | 2013-11-21 | Novozymes A/S | Compositions comprising lipase and methods of use thereof |
| AU2013279440B2 (en) | 2012-06-20 | 2016-10-06 | Novozymes A/S | Use of polypeptides having protease activity in animal feed and detergents |
| EP2914611B1 (en) | 2012-11-01 | 2018-08-29 | Novozymes A/S | Method for removal of dna |
| JP6514107B2 (ja) | 2012-12-07 | 2019-05-15 | ノボザイムス アクティーゼルスカブ | 細菌の付着防止 |
| EP2934177B1 (en) | 2012-12-21 | 2017-10-25 | Novozymes A/S | Polypeptides having protease activiy and polynucleotides encoding same |
| US9902946B2 (en) | 2013-01-03 | 2018-02-27 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| US9631164B2 (en) | 2013-03-21 | 2017-04-25 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
| WO2014173980A2 (en) | 2013-04-23 | 2014-10-30 | Novozymes A/S | Liquid automatic dish washing detergent compositions |
| AR096270A1 (es) | 2013-05-14 | 2015-12-16 | Novozymes As | Composiciones detergentes |
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| EP3004342B1 (en) | 2013-05-29 | 2023-01-11 | Danisco US Inc. | Novel metalloproteases |
| US10538751B2 (en) | 2013-06-06 | 2020-01-21 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| US10378001B2 (en) | 2013-06-27 | 2019-08-13 | Novozymes A/S | Subtilase variants and compositions comprising same |
| EP3013955A1 (en) | 2013-06-27 | 2016-05-04 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| US20160152925A1 (en) | 2013-07-04 | 2016-06-02 | Novozymes A/S | Polypeptides Having Anti-Redeposition Effect and Polynucleotides Encoding Same |
| EP3019603A1 (en) | 2013-07-09 | 2016-05-18 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
| WO2015014803A1 (en) | 2013-07-29 | 2015-02-05 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| CN117904081A (zh) | 2013-07-29 | 2024-04-19 | 诺维信公司 | 蛋白酶变体以及对其进行编码的多核苷酸 |
| WO2015051121A1 (en) | 2013-10-02 | 2015-04-09 | E. I. Du Pont De Nemours And Company | Hydrophobin composition and process for treating surfaces |
| WO2015049370A1 (en) | 2013-10-03 | 2015-04-09 | Novozymes A/S | Detergent composition and use of detergent composition |
| EP3083954B1 (en) | 2013-12-20 | 2018-09-26 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| US10208297B2 (en) | 2014-01-22 | 2019-02-19 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same for cleaning |
| US20160348035A1 (en) | 2014-03-05 | 2016-12-01 | Novozymes A/S | Compositions and Methods for Improving Properties of Non-Cellulosic Textile Materials with Xyloglucan Endotransglycosylase |
| EP3114272A1 (en) | 2014-03-05 | 2017-01-11 | Novozymes A/S | Compositions and methods for improving properties of cellulosic textile materials with xyloglucan endotransglycosylase |
| US10155935B2 (en) | 2014-03-12 | 2018-12-18 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
| US20170015950A1 (en) | 2014-04-01 | 2017-01-19 | Novozymes A/S | Polypeptides having alpha amylase activity |
| BR112016023188A2 (pt) | 2014-04-11 | 2018-01-16 | Novozymes As | uso de um polipeptídeo, composição detergente, métodos de lavagem para a lavagem de um item e de produção do polipeptídeo, polipeptídeo isolado, construção de ácido nucleico ou vetor de expressão, célula hospedeira recombinante, e, formulação de caldo inteiro ou composição de cultura de células |
| CN106715465B (zh) | 2014-04-15 | 2021-10-08 | 诺维信公司 | 具有脂肪酶活性的多肽和编码它们的多核苷酸 |
| WO2015181118A1 (en) | 2014-05-27 | 2015-12-03 | Novozymes A/S | Methods for producing lipases |
| EP3760713A3 (en) | 2014-05-27 | 2021-03-31 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| US20170121695A1 (en) | 2014-06-12 | 2017-05-04 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| WO2016001319A1 (en) | 2014-07-03 | 2016-01-07 | Novozymes A/S | Improved stabilization of non-protease enzyme |
| CN106661566A (zh) | 2014-07-04 | 2017-05-10 | 诺维信公司 | 枯草杆菌酶变体以及编码它们的多核苷酸 |
| EP3739029A1 (en) | 2014-07-04 | 2020-11-18 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| WO2016079110A2 (en) | 2014-11-19 | 2016-05-26 | Novozymes A/S | Use of enzyme for cleaning |
| US10287562B2 (en) | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| WO2016087619A1 (en) | 2014-12-04 | 2016-06-09 | Novozymes A/S | Liquid cleaning compositions comprising protease variants |
| CN107075493B (zh) | 2014-12-04 | 2020-09-01 | 诺维信公司 | 枯草杆菌酶变体以及编码它们的多核苷酸 |
| EP4067485A3 (en) | 2014-12-05 | 2023-01-04 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| ES2763235T3 (es) | 2014-12-15 | 2020-05-27 | Henkel Ag & Co Kgaa | Composición detergente que comprende variantes de subtilasa |
| WO2016096996A1 (en) | 2014-12-16 | 2016-06-23 | Novozymes A/S | Polypeptides having n-acetyl glucosamine oxidase activity |
| EP3234093B1 (en) | 2014-12-19 | 2020-05-27 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| CN118497177A (zh) | 2014-12-19 | 2024-08-16 | 诺维信公司 | 蛋白酶变体以及对其进行编码的多核苷酸 |
| EP3259350A4 (en) | 2015-02-16 | 2018-11-07 | Ozymes | Multi-domain enzymes having cutinase activity, compositions comprising same and uses thereof |
| CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
| EP3280800A1 (en) | 2015-04-10 | 2018-02-14 | Novozymes A/S | Detergent composition |
| WO2016162556A1 (en) | 2015-04-10 | 2016-10-13 | Novozymes A/S | Laundry method, use of dnase and detergent composition |
| WO2016176280A1 (en) | 2015-04-29 | 2016-11-03 | The Procter & Gamble Company | Method of treating a fabric |
| WO2016184944A1 (en) | 2015-05-19 | 2016-11-24 | Novozymes A/S | Odor reduction |
| EP3101108B1 (en) | 2015-06-04 | 2018-01-31 | The Procter and Gamble Company | Hand dishwashing liquid detergent composition |
| EP3101109B1 (en) | 2015-06-04 | 2018-03-07 | The Procter and Gamble Company | Hand dishwashing liquid detergent composition |
| CN108012543B (zh) | 2015-06-16 | 2022-01-04 | 诺维信公司 | 具有脂肪酶活性的多肽和编码它们的多核苷酸 |
| EP3310688A1 (en) | 2015-06-17 | 2018-04-25 | Novozymes A/S | Container |
| CN108012544A (zh) | 2015-06-18 | 2018-05-08 | 诺维信公司 | 枯草杆菌酶变体以及编码它们的多核苷酸 |
| EP3106508B1 (en) | 2015-06-18 | 2019-11-20 | Henkel AG & Co. KGaA | Detergent composition comprising subtilase variants |
| WO2016135351A1 (en) | 2015-06-30 | 2016-09-01 | Novozymes A/S | Laundry detergent composition, method for washing and use of composition |
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| CN107969136B (zh) | 2015-07-06 | 2021-12-21 | 诺维信公司 | 脂肪酶变体以及编码它们的多核苷酸 |
| CN108350443B (zh) | 2015-09-17 | 2022-06-28 | 诺维信公司 | 具有黄原胶降解活性的多肽以及编码它们的多核苷酸 |
| CN108026487B (zh) | 2015-09-17 | 2021-04-30 | 汉高股份有限及两合公司 | 包含具有黄原胶降解活性的多肽的洗涤剂组合物 |
| CN116064474A (zh) | 2015-10-07 | 2023-05-05 | 诺维信公司 | 多肽 |
| JP2018531783A (ja) | 2015-10-14 | 2018-11-01 | ノボザイムス アクティーゼルスカブ | 水濾過膜の洗浄 |
| US20180171318A1 (en) | 2015-10-14 | 2018-06-21 | Novozymes A/S | Polypeptides Having Protease Activity and Polynucleotides Encoding Same |
| US10479981B2 (en) | 2015-10-14 | 2019-11-19 | Novozymes A/S | DNase variants |
| MX388896B (es) | 2015-10-28 | 2025-03-20 | Novozymes As | Composicion detergente que comprende variantes de amilasa y proteasa. |
| CN108473974A (zh) | 2015-11-24 | 2018-08-31 | 诺维信公司 | 具有蛋白酶活性的多肽以及编码其的多核苷酸 |
| CN108431217B (zh) | 2015-12-01 | 2022-06-21 | 诺维信公司 | 用于产生脂肪酶的方法 |
| BR112018069220A2 (pt) | 2016-03-23 | 2019-01-22 | Novozymes As | uso de polipeptídeo que tem atividade de dnase para tratamento de tecidos |
| CN109312270B (zh) | 2016-04-08 | 2022-01-28 | 诺维信公司 | 洗涤剂组合物及其用途 |
| EP3693449A1 (en) | 2016-04-29 | 2020-08-12 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3243894A1 (en) | 2016-05-10 | 2017-11-15 | The Procter and Gamble Company | Cleaning composition |
| WO2017210188A1 (en) | 2016-05-31 | 2017-12-07 | Novozymes A/S | Stabilized liquid peroxide compositions |
| CN109715792A (zh) | 2016-06-03 | 2019-05-03 | 诺维信公司 | 枯草杆菌酶变体和对其进行编码的多核苷酸 |
| EP3475404A1 (en) | 2016-06-23 | 2019-05-01 | Novozymes A/S | Use of enzymes, composition and method for removing soil |
| EP3478827B1 (en) | 2016-06-30 | 2024-06-19 | Novozymes A/S | Lipase variants and compositions comprising surfactant and lipase variant |
| WO2018002261A1 (en) | 2016-07-01 | 2018-01-04 | Novozymes A/S | Detergent compositions |
| WO2018007435A1 (en) | 2016-07-05 | 2018-01-11 | Novozymes A/S | Pectate lyase variants and polynucleotides encoding same |
| WO2018007573A1 (en) | 2016-07-08 | 2018-01-11 | Novozymes A/S | Detergent compositions with galactanase |
| ES3000090T3 (en) | 2016-07-13 | 2025-02-27 | Procter & Gamble | Bacillus cibi dnase variants and uses thereof |
| EP3485008B1 (en) | 2016-07-18 | 2024-01-31 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| EP3284805B1 (en) | 2016-08-17 | 2020-02-19 | The Procter & Gamble Company | Cleaning composition comprising enzymes |
| US11512300B2 (en) | 2016-08-24 | 2022-11-29 | Novozymes A/S | Xanthan lyase variants and polynucleotides encoding same |
| CA3031609A1 (en) | 2016-08-24 | 2018-03-01 | Novozymes A/S | Gh9 endoglucanase variants and polynucleotides encoding same |
| KR102483218B1 (ko) | 2016-08-24 | 2023-01-02 | 헨켈 아게 운트 코. 카게아아 | 크산탄 리아제 변이체 i을 포함하는 세제 조성물 |
| US10988747B2 (en) | 2016-08-24 | 2021-04-27 | Henkel Ag & Co. Kgaa | Detergent composition comprising GH9 endoglucanase variants I |
| US20200140786A1 (en) | 2016-09-29 | 2020-05-07 | Novozymes A/S | Use of enzyme for washing, method for washing and warewashing composition |
| EP3532592A1 (en) | 2016-10-25 | 2019-09-04 | Novozymes A/S | Detergent compositions |
| US11753605B2 (en) | 2016-11-01 | 2023-09-12 | Novozymes A/S | Multi-core granules |
| KR20190086540A (ko) | 2016-12-01 | 2019-07-22 | 바스프 에스이 | 조성물 중 효소의 안정화 |
| US20190292493A1 (en) | 2016-12-12 | 2019-09-26 | Novozymes A/S | Use of polypeptides |
| WO2018177938A1 (en) | 2017-03-31 | 2018-10-04 | Novozymes A/S | Polypeptides having dnase activity |
| EP3601551A1 (en) | 2017-03-31 | 2020-02-05 | Novozymes A/S | Polypeptides having rnase activity |
| US11053483B2 (en) | 2017-03-31 | 2021-07-06 | Novozymes A/S | Polypeptides having DNase activity |
| WO2018177203A1 (en) | 2017-03-31 | 2018-10-04 | Novozymes A/S | Polypeptides having dnase activity |
| US20200109352A1 (en) | 2017-04-04 | 2020-04-09 | Novozymes A/S | Polypeptide compositions and uses thereof |
| WO2018185181A1 (en) | 2017-04-04 | 2018-10-11 | Novozymes A/S | Glycosyl hydrolases |
| US20200109354A1 (en) | 2017-04-04 | 2020-04-09 | Novozymes A/S | Polypeptides |
| DK3385361T3 (da) | 2017-04-05 | 2019-06-03 | Ab Enzymes Gmbh | Detergentsammensætninger omfattende bakterielle mannanaser |
| EP3385362A1 (en) | 2017-04-05 | 2018-10-10 | Henkel AG & Co. KGaA | Detergent compositions comprising fungal mannanases |
| EP3607042A1 (en) | 2017-04-06 | 2020-02-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018184818A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3478811B1 (en) | 2017-04-06 | 2019-10-16 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018184816A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| US20200190438A1 (en) | 2017-04-06 | 2020-06-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3607038A1 (en) | 2017-04-06 | 2020-02-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| US11499121B2 (en) | 2017-04-06 | 2022-11-15 | Novozymes A/S | Detergent compositions and uses thereof |
| US20200190437A1 (en) | 2017-04-06 | 2020-06-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| US11078445B2 (en) | 2017-05-05 | 2021-08-03 | Novozymes A/S | Compositions comprising lipase and sulfite |
| EP3401385A1 (en) | 2017-05-08 | 2018-11-14 | Henkel AG & Co. KGaA | Detergent composition comprising polypeptide comprising carbohydrate-binding domain |
| WO2018206535A1 (en) | 2017-05-08 | 2018-11-15 | Novozymes A/S | Carbohydrate-binding domain and polynucleotides encoding the same |
| US11525128B2 (en) | 2017-08-24 | 2022-12-13 | Novozymes A/S | GH9 endoglucanase variants and polynucleotides encoding same |
| WO2019038057A1 (en) | 2017-08-24 | 2019-02-28 | Novozymes A/S | VARIANTS OF XANTHANE LYASE AND POLYNUCLEOTIDES ENCODING THE SAME |
| US20210130744A1 (en) | 2017-08-24 | 2021-05-06 | Henkel Ag & Co. Kgaa | Detergent composition comprising xanthan lyase variants ii |
| US11624059B2 (en) | 2017-08-24 | 2023-04-11 | Henkel Ag & Co. Kgaa | Detergent compositions comprising GH9 endoglucanase variants II |
| CN111247235A (zh) | 2017-09-20 | 2020-06-05 | 诺维信公司 | 酶改善吸水性和/或白度的用途 |
| US11414814B2 (en) | 2017-09-22 | 2022-08-16 | Novozymes A/S | Polypeptides |
| JP7317811B2 (ja) | 2017-09-27 | 2023-07-31 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物 |
| EP3461892A3 (en) | 2017-09-27 | 2019-06-12 | The Procter & Gamble Company | Detergent compositions comprising lipases |
| WO2019076800A1 (en) | 2017-10-16 | 2019-04-25 | Novozymes A/S | CLEANING COMPOSITIONS AND USES THEREOF |
| US20200318037A1 (en) | 2017-10-16 | 2020-10-08 | Novozymes A/S | Low dusting granules |
| CN111448302A (zh) | 2017-10-16 | 2020-07-24 | 诺维信公司 | 低粉化颗粒 |
| MX2020004145A (es) | 2017-10-27 | 2020-08-03 | Novozymes As | Variantes de desoxirribonucleasa (dnasa). |
| PL3476935T3 (pl) | 2017-10-27 | 2022-03-28 | The Procter & Gamble Company | Kompozycje detergentowe zawierające odmiany polipeptydowe |
| DE102017125560A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine iii enthalten |
| CN111527190A (zh) | 2017-11-01 | 2020-08-11 | 诺维信公司 | 多肽以及包含此类多肽的组合物 |
| US11505767B2 (en) | 2017-11-01 | 2022-11-22 | Novozymes A/S | Methods for cleansing medical devices |
| DE102017125559A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine ii enthalten |
| DE102017125558A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine i enthalten |
| EP3704240A1 (en) | 2017-11-01 | 2020-09-09 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| WO2019094913A2 (en) | 2017-11-13 | 2019-05-16 | The Procter & Gamble Company | Personal care composition |
| EP3483247A1 (en) * | 2017-11-13 | 2019-05-15 | The Procter & Gamble Company | Cleaning composition comprising chaplin proteins |
| EP3483246A1 (en) * | 2017-11-13 | 2019-05-15 | The Procter & Gamble Company | Cleaning composition comprising hydrophobins |
| KR20200088433A (ko) | 2017-11-29 | 2020-07-22 | 바스프 에스이 | 보관 안정한 효소 제제, 이것의 제조 및 용도 |
| CN111670248A (zh) | 2017-12-04 | 2020-09-15 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| BR112020012133A2 (pt) | 2017-12-20 | 2020-11-24 | Basf Se | formulação para lavagem de roupa, usos de componentes, de pelo menos um composto da fórmula geral (i), de uma mistura de tensoativo, de pelo menos uma lipase de triacilglicerol fúngica, e, métodos para remover depósitos de gordura, para reduzir a redeposição de compostos gordurosos em artigo têxtil e para limpar artigos têxteis |
| EP3755793A1 (en) | 2018-02-23 | 2020-12-30 | Henkel AG & Co. KGaA | Detergent composition comprising xanthan lyase and endoglucanase variants |
| WO2019180111A1 (en) | 2018-03-23 | 2019-09-26 | Novozymes A/S | Subtilase variants and compositions comprising same |
| CN112262207B (zh) | 2018-04-17 | 2024-01-23 | 诺维信公司 | 洗涤剂组合物中包含碳水化合物结合活性的多肽及其在减少纺织品或织物中的褶皱的用途 |
| CN111989389A (zh) | 2018-04-19 | 2020-11-24 | 巴斯夫欧洲公司 | 组合物以及可用于该组合物的聚合物 |
| EP3781679A1 (en) | 2018-04-19 | 2021-02-24 | Novozymes A/S | Stabilized cellulase variants |
| EP3781680A1 (en) | 2018-04-19 | 2021-02-24 | Novozymes A/S | Stabilized cellulase variants |
| WO2019238761A1 (en) | 2018-06-15 | 2019-12-19 | Basf Se | Water soluble multilayer films containing wash active chemicals and enzymes |
| EP3814472A1 (en) | 2018-06-28 | 2021-05-05 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2020002608A1 (en) | 2018-06-29 | 2020-01-02 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3814489A1 (en) | 2018-06-29 | 2021-05-05 | Novozymes A/S | Subtilase variants and compositions comprising same |
| EP3818139A1 (en) | 2018-07-02 | 2021-05-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020007875A1 (en) | 2018-07-03 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3818140A1 (en) | 2018-07-06 | 2021-05-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020008024A1 (en) | 2018-07-06 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020030623A1 (en) | 2018-08-10 | 2020-02-13 | Basf Se | Packaging unit comprising a detergent composition containing an enzyme and at least one chelating agent |
| US20210340466A1 (en) | 2018-10-01 | 2021-11-04 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2020070014A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition comprising anionic surfactant and a polypeptide having rnase activity |
| WO2020070209A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition |
| WO2020070011A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition |
| WO2020070249A1 (en) | 2018-10-03 | 2020-04-09 | Novozymes A/S | Cleaning compositions |
| EP3861008A1 (en) | 2018-10-03 | 2021-08-11 | Novozymes A/S | Polypeptides having alpha-mannan degrading activity and polynucleotides encoding same |
| CN112805377A (zh) | 2018-10-05 | 2021-05-14 | 巴斯夫欧洲公司 | 在液体中稳定淀粉酶的化合物 |
| EP3677676A1 (en) | 2019-01-03 | 2020-07-08 | Basf Se | Compounds stabilizing amylases in liquids |
| MX2021003930A (es) | 2018-10-05 | 2021-06-04 | Basf Se | Compuestos estabilizadores de hidrolasas en liquidos. |
| CN112805376A (zh) | 2018-10-05 | 2021-05-14 | 巴斯夫欧洲公司 | 在液体中稳定水解酶的化合物 |
| EP3864122A1 (en) | 2018-10-09 | 2021-08-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3864123A1 (en) | 2018-10-09 | 2021-08-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| CN112996894A (zh) | 2018-10-11 | 2021-06-18 | 诺维信公司 | 清洁组合物及其用途 |
| EP3647397A1 (en) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Cleaning compositions containing dispersins iv |
| ES2981999T3 (es) | 2018-10-31 | 2024-10-14 | Henkel Ag & Co Kgaa | Composiciones limpiadoras que contienen dispersinas V |
| WO2020104231A1 (en) | 2018-11-19 | 2020-05-28 | Basf Se | Powders and granules containing a chelating agent and an enzyme |
| US20220056379A1 (en) | 2018-12-03 | 2022-02-24 | Novozymes A/S | Powder Detergent Compositions |
| CN113302270A (zh) | 2018-12-03 | 2021-08-24 | 诺维信公司 | 低pH粉末洗涤剂组合物 |
| CN113366103A (zh) | 2018-12-21 | 2021-09-07 | 诺维信公司 | 具有肽聚糖降解活性的多肽以及编码其的多核苷酸 |
| CN113330101A (zh) | 2018-12-21 | 2021-08-31 | 诺维信公司 | 包含金属蛋白酶的洗涤剂袋 |
| EP3702452A1 (en) | 2019-03-01 | 2020-09-02 | Novozymes A/S | Detergent compositions comprising two proteases |
| CN113544246A (zh) | 2019-03-08 | 2021-10-22 | 巴斯夫欧洲公司 | 阳离子表面活性剂及其在洗衣用洗涤剂组合物中的用途 |
| AU2020242303B2 (en) | 2019-03-21 | 2026-01-08 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| MX2021011981A (es) | 2019-04-03 | 2021-11-03 | Novozymes As | Polipeptidos que tienen actividad de beta-glucanasa, polinucleotidos que los codifican y usos de los mismos en composiciones de limpieza y de detergente. |
| EP3953462A1 (en) | 2019-04-10 | 2022-02-16 | Novozymes A/S | Polypeptide variants |
| CN113795576A (zh) | 2019-04-12 | 2021-12-14 | 诺维信公司 | 稳定化的糖苷水解酶变体 |
| WO2020229480A1 (en) | 2019-05-14 | 2020-11-19 | Basf Se | Compounds stabilizing hydrolases in liquids |
| CN114364778B (zh) | 2019-07-12 | 2024-08-13 | 诺维信公司 | 用于洗涤剂的酶性乳剂 |
| US20220325204A1 (en) | 2019-08-27 | 2022-10-13 | Novozymes A/S | Detergent composition |
| EP4022020A1 (en) | 2019-08-27 | 2022-07-06 | Novozymes A/S | Composition comprising a lipase |
| US20220315866A1 (en) | 2019-09-19 | 2022-10-06 | Novozymes A/S | Detergent Composition |
| US20220340843A1 (en) | 2019-10-03 | 2022-10-27 | Novozymes A/S | Polypeptides comprising at least two carbohydrate binding domains |
| CN114585718A (zh) | 2019-10-18 | 2022-06-03 | 巴斯夫欧洲公司 | 储存稳定的包含水解酶的液体 |
| CN113891931A (zh) | 2019-11-29 | 2022-01-04 | 巴斯夫欧洲公司 | 组合物和可以用于该类组合物的聚合物 |
| WO2021115912A1 (en) | 2019-12-09 | 2021-06-17 | Basf Se | Formulations comprising a hydrophobically modified polyethyleneimine and one or more enzymes |
| CN114846128A (zh) | 2019-12-20 | 2022-08-02 | 汉高股份有限及两合公司 | 包含分散蛋白viii的清洁组合物 |
| KR20220119607A (ko) | 2019-12-20 | 2022-08-30 | 헨켈 아게 운트 코. 카게아아 | 디스페르신 ix를 포함하는 세정 조성물 |
| WO2021122117A1 (en) | 2019-12-20 | 2021-06-24 | Henkel Ag & Co. Kgaa | Cleaning composition coprising a dispersin and a carbohydrase |
| WO2021121394A1 (en) | 2019-12-20 | 2021-06-24 | Novozymes A/S | Stabilized liquid boron-free enzyme compositions |
| WO2021123307A2 (en) | 2019-12-20 | 2021-06-24 | Novozymes A/S | Polypeptides having proteolytic activity and use thereof |
| KR20220119609A (ko) | 2019-12-20 | 2022-08-30 | 헨켈 아게 운트 코. 카게아아 | 디스페르신 vi을 포함하는 세정 조성물 |
| MX2022007732A (es) | 2019-12-23 | 2022-07-19 | Procter & Gamble | Composiciones que comprenden enzimas. |
| WO2021130167A1 (en) | 2019-12-23 | 2021-07-01 | Novozymes A/S | Enzyme compositions and uses thereof |
| WO2021148364A1 (en) | 2020-01-23 | 2021-07-29 | Novozymes A/S | Enzyme compositions and uses thereof |
| JP7731360B2 (ja) | 2020-01-31 | 2025-08-29 | ノボザイムス アクティーゼルスカブ | マンナナーゼバリアント及びそれをコードするポリヌクレオチド |
| US12497606B2 (en) | 2020-01-31 | 2025-12-16 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| EP3892708A1 (en) | 2020-04-06 | 2021-10-13 | Henkel AG & Co. KGaA | Cleaning compositions comprising dispersin variants |
| US20230143128A1 (en) | 2020-04-08 | 2023-05-11 | Novozymes A/S | Carbohydrate binding module variants |
| WO2021214059A1 (en) | 2020-04-21 | 2021-10-28 | Novozymes A/S | Cleaning compositions comprising polypeptides having fructan degrading activity |
| EP3907271A1 (en) | 2020-05-07 | 2021-11-10 | Novozymes A/S | Cleaning composition, use and method of cleaning |
| WO2021239818A1 (en) | 2020-05-26 | 2021-12-02 | Novozymes A/S | Subtilase variants and compositions comprising same |
| JP2023530443A (ja) | 2020-06-18 | 2023-07-18 | ビーエーエスエフ ソシエタス・ヨーロピア | 組成物及びその使用 |
| EP4172298A1 (en) | 2020-06-24 | 2023-05-03 | Novozymes A/S | Use of cellulases for removing dust mite from textile |
| EP3936593A1 (en) | 2020-07-08 | 2022-01-12 | Henkel AG & Co. KGaA | Cleaning compositions and uses thereof |
| JP7736383B2 (ja) | 2020-07-09 | 2025-09-09 | ベーアーエスエフ・エスエー | 組成物及びその用途 |
| WO2022008732A1 (en) | 2020-07-10 | 2022-01-13 | Basf Se | Enhancing the activity of antimicrobial preservatives |
| BR112023003468A2 (pt) | 2020-08-25 | 2023-04-11 | Novozymes As | Variantes de uma xiloglucanase da família 44 |
| US20230265408A1 (en) | 2020-08-28 | 2023-08-24 | Novozymes A/S | Protease variants with improved solubility |
| EP4217368A1 (en) | 2020-09-22 | 2023-08-02 | Basf Se | Improved combination of protease and protease inhibitor with secondary enzyme |
| CN116507725A (zh) | 2020-10-07 | 2023-07-28 | 诺维信公司 | α-淀粉酶变体 |
| WO2022084303A2 (en) | 2020-10-20 | 2022-04-28 | Novozymes A/S | Use of polypeptides having dnase activity |
| WO2022083949A1 (en) | 2020-10-20 | 2022-04-28 | Basf Se | Compositions and their use |
| EP4237525A1 (en) | 2020-10-28 | 2023-09-06 | Novozymes A/S | Use of lipoxygenase |
| BR112023008326A2 (pt) | 2020-10-29 | 2023-12-12 | Novozymes As | Variantes de lipase e composições compreendendo tais variantes de lipase |
| CN116670261A (zh) | 2020-11-13 | 2023-08-29 | 诺维信公司 | 包含脂肪酶的洗涤剂组合物 |
| WO2022106400A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of immunochemically different proteases |
| WO2022106404A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of proteases |
| EP4032966A1 (en) | 2021-01-22 | 2022-07-27 | Novozymes A/S | Liquid enzyme composition with sulfite scavenger |
| EP4284905A1 (en) | 2021-01-28 | 2023-12-06 | Novozymes A/S | Lipase with low malodor generation |
| EP4039806A1 (en) | 2021-02-04 | 2022-08-10 | Henkel AG & Co. KGaA | Detergent composition comprising xanthan lyase and endoglucanase variants with im-proved stability |
| EP4291646A2 (en) | 2021-02-12 | 2023-12-20 | Novozymes A/S | Alpha-amylase variants |
| CN117015592A (zh) | 2021-02-12 | 2023-11-07 | 诺维信公司 | 稳定的生物洗涤剂 |
| EP4047088A1 (en) | 2021-02-22 | 2022-08-24 | Basf Se | Amylase variants |
| MX2023009756A (es) | 2021-02-22 | 2023-09-04 | Basf Se | Variantes de amilasa. |
| EP4305146A1 (en) | 2021-03-12 | 2024-01-17 | Novozymes A/S | Polypeptide variants |
| US20240060061A1 (en) | 2021-03-15 | 2024-02-22 | Novozymes A/S | Dnase variants |
| EP4060036A1 (en) | 2021-03-15 | 2022-09-21 | Novozymes A/S | Polypeptide variants |
| US20240218300A1 (en) | 2021-03-26 | 2024-07-04 | Novozymes A/S | Detergent composition with reduced polymer content |
| EP4359518A1 (en) | 2021-06-23 | 2024-05-01 | Novozymes A/S | Alpha-amylase polypeptides |
| EP4134423A1 (en) | 2021-08-12 | 2023-02-15 | Henkel AG & Co. KGaA | Sprayable laundry pre-treatment composition |
| EP4416257A1 (en) | 2021-10-12 | 2024-08-21 | Novozymes A/S | Endoglucanase with improved stability |
| US20240400945A1 (en) | 2021-10-13 | 2024-12-05 | Basf Se | Compositions comprising polymers, polymers, and their use |
| WO2023088777A1 (en) | 2021-11-22 | 2023-05-25 | Basf Se | Compositions comprising polymers, polymers, and their use |
| CN118871559A (zh) | 2021-12-21 | 2024-10-29 | 诺维信公司 | 包含脂肪酶和加强剂的组合物 |
| WO2023117962A1 (en) | 2021-12-21 | 2023-06-29 | Basf Se | Chemical product passport |
| EP4206309A1 (en) | 2021-12-30 | 2023-07-05 | Novozymes A/S | Protein particles with improved whiteness |
| CN118647646A (zh) | 2022-02-04 | 2024-09-13 | 巴斯夫欧洲公司 | 包含聚合物的组合物、聚合物及其用途 |
| EP4234664A1 (en) | 2022-02-24 | 2023-08-30 | Evonik Operations GmbH | Composition comprising glucolipids and enzymes |
| US20250179393A1 (en) | 2022-03-02 | 2025-06-05 | Novozymes A/S | Use of xyloglucanase for improvement of sustainability of detergents |
| CA3242259A1 (en) | 2022-03-04 | 2023-09-07 | Novozymes A/S | Dnase variants and compositions |
| CN118974228A (zh) | 2022-04-08 | 2024-11-15 | 诺维信公司 | 氨基己糖苷酶变体和组合物 |
| DE102022205593A1 (de) | 2022-06-01 | 2023-12-07 | Henkel Ag & Co. Kgaa | Wasch- und reinigungsmittel mit verbesserter enzymstabilität |
| DE102022205588A1 (de) | 2022-06-01 | 2023-12-07 | Henkel Ag & Co. Kgaa | Wasch- und reinigungsmittel mit verbesserter enzymstabilität |
| DE102022205591A1 (de) | 2022-06-01 | 2023-12-07 | Henkel Ag & Co. Kgaa | Wasch- und reinigungsmittel mit verbesserter enzymstabilität |
| DE102022205594A1 (de) | 2022-06-01 | 2023-12-07 | Henkel Ag & Co. Kgaa | Leistungsverbesserte und lagerstabile protease-varianten |
| EP4544015A2 (en) | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| EP4569099A1 (en) | 2022-08-11 | 2025-06-18 | Basf Se | Enzyme compositions comprising protease, mannanase, and/or cellulase |
| WO2024033135A2 (en) | 2022-08-11 | 2024-02-15 | Basf Se | Amylase variants |
| EP4569096A2 (en) | 2022-08-11 | 2025-06-18 | Basf Se | Enzyme compositions comprising an amylase |
| US20260055347A1 (en) | 2022-08-11 | 2026-02-26 | Basf Se | Amylase variants |
| EP4324900A1 (en) | 2022-08-17 | 2024-02-21 | Henkel AG & Co. KGaA | Detergent composition comprising enzymes |
| WO2024083589A1 (en) | 2022-10-18 | 2024-04-25 | Basf Se | Detergent compositions, polymers and methods of manufacturing the same |
| CN120051554A (zh) | 2022-10-20 | 2025-05-27 | 诺维信公司 | 洗涤剂中的脂质去除 |
| EP4612286A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4612285A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2024094735A1 (en) | 2022-11-04 | 2024-05-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| DE102022131732A1 (de) | 2022-11-30 | 2024-06-06 | Henkel Ag & Co. Kgaa | Verbesserte Waschleistung durch den Einsatz einer Protease fusioniert mit speziellem Adhäsionsvermittlerpeptid |
| WO2024115754A1 (en) | 2022-12-02 | 2024-06-06 | Basf Se | Aqueous compositions containing polyalkoxylates, polyalkoxylates, and use |
| CN120225643A (zh) | 2022-12-05 | 2025-06-27 | 诺维信公司 | 包含脂肪酶和肽的组合物 |
| CN120265742A (zh) | 2022-12-05 | 2025-07-04 | 诺维信公司 | 蛋白酶变体以及编码其的多核苷酸 |
| CN120265743A (zh) | 2022-12-14 | 2025-07-04 | 诺维信公司 | 改善的脂肪酶(gcl1)变体 |
| EP4389864A1 (en) | 2022-12-20 | 2024-06-26 | Basf Se | Cutinases |
| WO2024131880A2 (en) | 2022-12-23 | 2024-06-27 | Novozymes A/S | Detergent composition comprising catalase and amylase |
| CN120435539A (zh) | 2023-01-23 | 2025-08-05 | 诺维信公司 | 清洁组合物及其用途 |
| EP4410938A1 (en) | 2023-02-02 | 2024-08-07 | AMSilk GmbH | Automatic dishwashing composition comprising a structural polypeptide |
| WO2024194245A1 (en) | 2023-03-21 | 2024-09-26 | Novozymes A/S | Detergent compositions based on biosurfactants |
| KR20250174069A (ko) | 2023-04-12 | 2025-12-11 | 노보자임스 에이/에스 | 알칼리성 포스파타아제 활성을 갖는 폴리펩타이드를 포함하는 조성물 |
| EP4461795A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| EP4461796A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| EP4709830A1 (en) | 2023-05-11 | 2026-03-18 | Novozymes A/S | Automatic dishwashing detergent compositions comprising a lipase |
| CN121358834A (zh) | 2023-06-28 | 2026-01-16 | 诺维信公司 | 包含脂肪酶的洗涤剂组合物 |
| CN121712874A (zh) | 2023-08-15 | 2026-03-20 | 赢创运营有限公司 | 用于洗涤毛的生物表面活性剂 |
| WO2025088003A1 (en) | 2023-10-24 | 2025-05-01 | Novozymes A/S | Use of xyloglucanase for replacement of optical brightener |
| WO2025103765A1 (en) | 2023-11-17 | 2025-05-22 | Novozymes A/S | Lytic polysaccharide monooxygenases and their use in detergent |
| WO2025114053A1 (en) | 2023-11-30 | 2025-06-05 | Novozymes A/S | Biopolymers for use in detergent |
| WO2025132258A1 (en) | 2023-12-20 | 2025-06-26 | Basf Se | Stabilized enzyme composition comprising a protease |
| WO2025153046A1 (en) | 2024-01-19 | 2025-07-24 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2025202370A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202379A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202369A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4624572A1 (en) | 2024-03-27 | 2025-10-01 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202372A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202374A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025257254A1 (en) | 2024-06-12 | 2025-12-18 | Novozymes A/S | Lipases and lipase variants and the use thereof |
| WO2026017636A1 (en) | 2024-07-17 | 2026-01-22 | Novozymes A/S | Compositions comprising combination of enzymes |
| WO2026032783A1 (en) | 2024-08-06 | 2026-02-12 | Evonik Operations Gmbh | Bacillus velezensis strains in cleaning and animal feeding |
| EP4692292A1 (en) | 2024-08-06 | 2026-02-11 | Evonik Operations GmbH | Improved method for germinating bacterial spores |
| WO2026046881A1 (en) | 2024-08-26 | 2026-03-05 | Novozymes A/S | Compositions comprising a hexosaminidase and a protease |
| WO2026068782A1 (en) | 2024-09-30 | 2026-04-02 | Novozymes A/S | Protease variants and polynucleotides encoding same |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| GB1483591A (en) | 1973-07-23 | 1977-08-24 | Novo Industri As | Process for coating water soluble or water dispersible particles by means of the fluid bed technique |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| GB1590432A (en) | 1976-07-07 | 1981-06-03 | Novo Industri As | Process for the production of an enzyme granulate and the enzyme granuate thus produced |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DK263584D0 (da) | 1984-05-29 | 1984-05-29 | Novo Industri As | Enzymholdige granulater anvendt som detergentadditiver |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EG18543A (en) | 1986-02-20 | 1993-07-30 | Albright & Wilson | Protected enzyme systems |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| EP0471265B1 (en) | 1988-01-07 | 1995-10-25 | Novo Nordisk A/S | Specific protease |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| US6287841B1 (en) | 1988-02-11 | 2001-09-11 | Genencor International, Inc. | High alkaline serine protease |
| WO1989009259A1 (en) | 1988-03-24 | 1989-10-05 | Novo-Nordisk A/S | A cellulase preparation |
| US5776757A (en) | 1988-03-24 | 1998-07-07 | Novo Nordisk A/S | Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof |
| KR100225087B1 (ko) | 1990-03-23 | 1999-10-15 | 한스 발터라벤 | 피타아제의 식물내 발현 |
| DK115890D0 (da) | 1990-05-09 | 1990-05-09 | Novo Nordisk As | Enzym |
| CA2082279C (en) | 1990-05-09 | 2007-09-04 | Grethe Rasmussen | Cellulase preparation comprising an endoglucanase enzyme |
| DE69133035T2 (de) | 1991-01-16 | 2003-02-13 | The Procter & Gamble Company, Cincinnati | Kompakte Waschmittelzusammensetzungen mit hochaktiven Cellulasen |
| DE4112440C1 (https=) | 1991-04-16 | 1992-10-22 | Diagen Institut Fuer Molekularbiologische Diagnostik Gmbh, 4000 Duesseldorf, De | |
| EP0511456A1 (en) | 1991-04-30 | 1992-11-04 | The Procter & Gamble Company | Liquid detergents with aromatic borate ester to inhibit proteolytic enzyme |
| DK0583420T3 (da) | 1991-04-30 | 1996-07-29 | Procter & Gamble | Builderholdige flydende detergenter med borsyre-polyol-kompleks til inhibering af proteolytisk enzym |
| KR100258460B1 (ko) | 1991-05-01 | 2000-06-01 | 한센 핀 베네드 | 안정화 효소 및 세제 조성물 |
| DK72992D0 (da) | 1992-06-01 | 1992-06-01 | Novo Nordisk As | Enzym |
| JPH07509129A (ja) | 1992-07-23 | 1995-10-12 | ジェネンコー インターナショナル インコーポレイテッド | シュードモナスシュードアルカリゲネス由来のリパーゼモジュレーター遺伝子のクローニング及び発現 |
| EP1431389A3 (en) | 1992-10-06 | 2004-06-30 | Novozymes A/S | Cellulase variants |
| DE69332030T2 (de) | 1992-12-10 | 2002-10-02 | Dsm N.V., Heerlen | Herstellung von heterologen proteinen in filamentösen fungi |
| DK52393D0 (https=) | 1993-05-05 | 1993-05-05 | Novo Nordisk As | |
| EP0724631A1 (en) | 1993-10-13 | 1996-08-07 | Novo Nordisk A/S | H 2?o 2?-stable peroxidase variants |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| WO1995024471A1 (en) | 1994-03-08 | 1995-09-14 | Novo Nordisk A/S | Novel alkaline cellulases |
| DE4411349A1 (de) * | 1994-03-31 | 1995-10-05 | Henkel Kgaa | Lipasehaltiges Textilwaschmittel |
| US6599730B1 (en) | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
| US5741665A (en) | 1994-05-10 | 1998-04-21 | University Of Hawaii | Light-regulated promoters for production of heterologous proteins in filamentous fungi |
| DE69535733T2 (de) | 1994-10-06 | 2009-04-23 | Novozymes A/S | Ein enzympräparat mit endoglucanase aktivität |
| GB2296011B (en) | 1994-12-13 | 1999-06-16 | Solvay | Novel fusarium isolate and lipases, cutinases and enzyme compositions derived therefrom |
| EP0815209B2 (en) | 1995-03-17 | 2015-02-25 | Novozymes A/S | Novel endoglucanases |
| US6313081B1 (en) | 1995-04-28 | 2001-11-06 | Henkel Kommanditgesellschaft Auf Aktien (Kgaa) | Detergents comprising cellulases |
| ATE429490T1 (de) | 1995-05-05 | 2009-05-15 | Novozymes As | Protease-varianten und verbindungen |
| WO1997007202A1 (en) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Novel lipolytic enzymes |
| US6153745A (en) | 1995-09-22 | 2000-11-28 | Amersham Pharmacia Biotech Uk Limited | Relating to mutagenesis of nucleic acids |
| US6361974B1 (en) | 1995-12-07 | 2002-03-26 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
| US6344328B1 (en) | 1995-12-07 | 2002-02-05 | Diversa Corporation | Method for screening for enzyme activity |
| AU3938997A (en) | 1996-08-26 | 1998-03-19 | Novo Nordisk A/S | A novel endoglucanase |
| BR9711479B1 (pt) | 1996-09-17 | 2009-08-11 | variante de celulase tendo uma resistência aumentada a tensìdeo de ánion. | |
| CA2265734A1 (en) | 1996-10-08 | 1998-04-16 | Novo Nordisk A/S | Diaminobenzoic acid derivatives as dye precursors |
| BR9712473B1 (pt) | 1996-11-04 | 2009-08-11 | variantes de subtilase e composições. | |
| EP1559788A1 (en) | 1997-04-09 | 2005-08-03 | Danisco A/S | Use lipase for improving doughs and baked products |
| AU7908898A (en) | 1997-07-04 | 1999-01-25 | Novo Nordisk A/S | Family 6 endo-1,4-beta-glucanase variants and cleaning composit ions containing them |
| DK1032686T3 (da) | 1997-11-19 | 2005-06-27 | Genencor Int | Cellulase dannet af Actinomyceter og fremgangsmåde til frembringelse heraf |
| JP2004500019A (ja) | 1999-03-26 | 2004-01-08 | ディベルサ コーポレーション | 定方向進化におけるエキソヌクレアーゼ仲介核酸再集合 |
| US6254645B1 (en) | 1999-08-20 | 2001-07-03 | Genencor International, Inc. | Enzymatic modification of the surface of a polyester fiber or article |
| DE60045117D1 (de) | 1999-08-30 | 2010-11-25 | Monsanto Technology Llc | Pflanzen-Sterol-Acyltransferasen |
| US6933140B1 (en) | 1999-11-05 | 2005-08-23 | Genencor International, Inc. | Enzymes useful for changing the properties of polyester |
| DE19953854C2 (de) | 1999-11-09 | 2002-01-17 | Max Planck Gesellschaft | Verfahren zur Herstellung von Biopolymeren mit veränderten Eigenschaften |
| FI108204B (fi) | 1999-11-25 | 2001-11-30 | Kari Johannes Kirjavainen | Kalvo energioiden muuntamiseksi |
| GB0002660D0 (en) | 2000-02-04 | 2000-03-29 | Biomade B V | Method of stabilizing a hydrophobin-containing solution and a method of coatinga surface with a hydrophobin |
| GB0002663D0 (en) | 2000-02-04 | 2000-03-29 | Biomade B V | Method of stabalizing a hydrophobin-containing solution and a method of coating a surface with a hydrophobin |
| GB0007770D0 (en) | 2000-03-30 | 2000-05-17 | Biomade B V | Protein capable of self-assembly at a hydrophobic hydrophillic interface, method of coating a surface, method of stabilizing a dispersion, method of stabilizi |
| EP1307548A2 (en) | 2000-07-13 | 2003-05-07 | Maxygen, Inc. | Novel lipase genes |
| JP4273504B2 (ja) * | 2002-10-23 | 2009-06-03 | 株式会社 東北テクノアーチ | プラスチックの分解法及びそれを利用した有用物質の製造方法 |
| GB0405637D0 (en) | 2004-03-12 | 2004-04-21 | Danisco | Protein |
| US7241734B2 (en) | 2004-08-18 | 2007-07-10 | E. I. Du Pont De Nemours And Company | Thermophilic hydrophobin proteins and applications for surface modification |
| CA2591221A1 (en) | 2004-12-23 | 2006-07-06 | Genencor International, Inc. | Neutral cellulase catalytic core and method of producing same |
| TW200639179A (en) | 2005-02-07 | 2006-11-16 | Basf Ag | Method for coating surfaces with hydrophobins |
| CA2602158A1 (en) | 2005-03-30 | 2006-10-05 | Basf Aktiengesellschaft | Use of hydrophobins for the surface treatment of hardened mineral building materials, natural stone and ceramics |
| EP1866150B1 (de) | 2005-03-31 | 2016-10-19 | Basf Se | Metallische substrate mit polypeptiden als haftvermittler |
| US20090101167A1 (en) * | 2005-08-01 | 2009-04-23 | Basf Aktiengesellschaft | Use of Surface-Active Non-Enzymatic Proteins for Washing Textiles |
| EP1764148A1 (de) | 2005-09-14 | 2007-03-21 | Jäger, Urs | Vorrichtung zum Herstellen von Mischgetränken und Druckbehälter dafür |
| US20100094026A1 (en) * | 2005-11-01 | 2010-04-15 | Reverse Proteomics Research Institute Co., Ltd. | Method of screening compound useful in treating allergic disease |
| MY143739A (en) | 2006-01-31 | 2011-07-15 | Unilever Plc | Aerated compositions comprising hydrophobin |
| ZA200803491B (en) | 2006-01-31 | 2009-11-25 | Unilever Plc | Aerated product |
| ES2374320T3 (es) | 2006-08-15 | 2012-02-15 | Basf Se | Procedimiento para la producción de preparaciones de hidrofobina secas de flujo libre. |
| BRPI0808144A2 (pt) * | 2007-02-27 | 2014-06-24 | Danisco Us Inc | Enzimas de limpeza e prevenção de mal odor |
| WO2008107439A1 (de) | 2007-03-06 | 2008-09-12 | Basf Se | Mit hydrophobinen modifizierte offenzellige schaumstoffe |
| CA2679719C (en) | 2007-03-12 | 2015-04-28 | Basf Se | Method of treating cellulosic materials with hydrophobins |
| BRPI0808588A2 (pt) | 2007-03-26 | 2014-08-12 | Unilever Nv | "produtos alimentícios aerados e processo para produzir um produto alimentício aerado" |
| JP4480795B2 (ja) | 2007-03-28 | 2010-06-16 | パイオニア株式会社 | 楽曲再生装置、楽曲再生方法及び楽曲再生プログラム |
| EP2042155A1 (de) | 2007-09-28 | 2009-04-01 | Basf Se | Verfahren zum Entfernen von wasserunlöslichen Substanzen von Substratoberflächen |
| AU2009304092B2 (en) | 2008-10-16 | 2013-09-05 | Unilever Plc | Hydrophobin solution containing antifoam |
| AU2009328324B2 (en) | 2008-12-16 | 2013-03-21 | Unilever Plc | Method for extracting hydrophobin from a solution |
-
2012
- 2012-04-04 AU AU2012241055A patent/AU2012241055A1/en not_active Abandoned
- 2012-04-04 US US14/110,481 patent/US20140031272A1/en not_active Abandoned
- 2012-04-04 AR ARP120101164A patent/AR085845A1/es unknown
- 2012-04-04 BR BR112013025811A patent/BR112013025811A2/pt not_active IP Right Cessation
- 2012-04-04 MX MX2013011617A patent/MX2013011617A/es not_active Application Discontinuation
- 2012-04-04 WO PCT/IB2012/051660 patent/WO2012137147A1/en not_active Ceased
- 2012-04-04 CA CA2830579A patent/CA2830579A1/en not_active Abandoned
- 2012-04-04 RU RU2013149861/10A patent/RU2013149861A/ru not_active Application Discontinuation
- 2012-04-04 EP EP12716642.9A patent/EP2694537A1/en not_active Withdrawn
- 2012-04-04 KR KR1020137029372A patent/KR20140024365A/ko not_active Withdrawn
- 2012-04-04 JP JP2014503258A patent/JP6027092B2/ja not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190028754A (ko) * | 2016-07-12 | 2019-03-19 | 까르비오 | 신규한 에스테라아제 및 그의 용도 |
| KR20230011505A (ko) * | 2016-07-12 | 2023-01-20 | 까르비오 | 신규한 에스테라아제 및 그의 용도 |
| WO2023200284A1 (ko) * | 2022-04-15 | 2023-10-19 | 재단법인대구경북과학기술원 | 생체 시료 내 지질 연관 단백질의 질량 분석을 위한 지질 연관 단백질의 정제 및 농축 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6027092B2 (ja) | 2016-11-16 |
| US20140031272A1 (en) | 2014-01-30 |
| CA2830579A1 (en) | 2012-10-11 |
| WO2012137147A1 (en) | 2012-10-11 |
| JP2014516509A (ja) | 2014-07-17 |
| AU2012241055A1 (en) | 2013-08-15 |
| MX2013011617A (es) | 2013-11-21 |
| BR112013025811A2 (pt) | 2016-11-29 |
| EP2694537A1 (en) | 2014-02-12 |
| RU2013149861A (ru) | 2015-05-20 |
| AR085845A1 (es) | 2013-10-30 |
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