KR20130116386A - 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 - Google Patents

히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 Download PDF

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KR20130116386A
KR20130116386A KR1020137026841A KR20137026841A KR20130116386A KR 20130116386 A KR20130116386 A KR 20130116386A KR 1020137026841 A KR1020137026841 A KR 1020137026841A KR 20137026841 A KR20137026841 A KR 20137026841A KR 20130116386 A KR20130116386 A KR 20130116386A
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hyaluronan
hyaluronidase
pharmaceutical composition
soluble
seq
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Korean (ko)
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그레고리 아이 프로스트
핑 지앙
커티스 비. 톰슨
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할로자임, 아이엔씨
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/096—Polyesters; Polyamides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types

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  • Bioinformatics & Cheminformatics (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Analytical Chemistry (AREA)
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  • Food Science & Technology (AREA)
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KR1020137026841A 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 Ceased KR20130116386A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12427808P 2008-04-14 2008-04-14
US61/124,278 2008-04-14
US13035708P 2008-05-29 2008-05-29
US61/130,357 2008-05-29
US19562408P 2008-10-08 2008-10-08
US61/195,624 2008-10-08
PCT/US2009/002352 WO2009128917A2 (en) 2008-04-14 2009-04-14 Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions

Related Parent Applications (1)

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KR1020107025485A Division KR20100135291A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도

Related Child Applications (1)

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KR1020157002593A Division KR101647932B1 (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도

Publications (1)

Publication Number Publication Date
KR20130116386A true KR20130116386A (ko) 2013-10-23

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Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020137026841A Ceased KR20130116386A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
KR1020107025485A Ceased KR20100135291A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
KR1020167011691A Ceased KR20160052812A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
KR1020157002593A Expired - Fee Related KR101647932B1 (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020107025485A Ceased KR20100135291A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
KR1020167011691A Ceased KR20160052812A (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
KR1020157002593A Expired - Fee Related KR101647932B1 (ko) 2008-04-14 2009-04-14 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도

Country Status (11)

Country Link
US (5) US20100003238A1 (https=)
EP (3) EP2662090A1 (https=)
JP (3) JP2011519361A (https=)
KR (4) KR20130116386A (https=)
CN (2) CN102065886A (https=)
AU (1) AU2009236635B2 (https=)
CA (2) CA3096629A1 (https=)
IL (1) IL208518A (https=)
NZ (2) NZ601248A (https=)
SG (1) SG187427A1 (https=)
WO (1) WO2009128917A2 (https=)

Cited By (5)

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WO2020022791A1 (ko) * 2018-07-25 2020-01-30 (주)알테오젠 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물
WO2021150079A1 (ko) * 2020-01-23 2021-07-29 (주)알테오젠 안정성이 향상된 신규 히알루론산 가수분해 효소 변이체 및 이를 포함하는 약제학적 조성물
US12221638B2 (en) 2020-08-07 2025-02-11 Alteogen Inc. Method for producing recombinant hyaluronidase
US12570766B2 (en) 2019-03-25 2026-03-10 Alteogen Inc. Pharmaceutical composition for subcutaneous administration containing human hyaluronidase PH20 variant and drug
US12618055B2 (en) 2020-01-23 2026-05-05 Alteogen Inc. Hyaluronidase variants with improved stability and pharmaceutical composition comprising the same

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CN102065886A (zh) 2011-05-18
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JP2014041131A (ja) 2014-03-06
KR20100135291A (ko) 2010-12-24
NZ588638A (en) 2012-09-28
EP3192525A1 (en) 2017-07-19
CN103381267A (zh) 2013-11-06
US20200368330A1 (en) 2020-11-26
US20250222078A1 (en) 2025-07-10
US20100003238A1 (en) 2010-01-07
US20120171153A1 (en) 2012-07-05
IL208518A0 (en) 2010-12-30
US20190336587A1 (en) 2019-11-07
US10328130B2 (en) 2019-06-25
NZ601248A (en) 2014-06-27
EP2662090A1 (en) 2013-11-13
CA3096629A1 (en) 2009-10-22
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EP2285402A2 (en) 2011-02-23
IL208518A (en) 2017-02-28
JP2011519361A (ja) 2011-07-07
US20130028856A9 (en) 2013-01-31
KR20160052812A (ko) 2016-05-12
JP6262700B2 (ja) 2018-01-17
JP2016074664A (ja) 2016-05-12
CA2721229A1 (en) 2009-10-22
JP5898146B2 (ja) 2016-04-06
SG187427A1 (en) 2013-02-28
WO2009128917A2 (en) 2009-10-22
AU2009236635A1 (en) 2009-10-22
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AU2009236635B2 (en) 2014-02-13

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